234:
440:
4870:
430:, one of the last steps in cholesterol biosynthesis, and were formerly used to treat hypercholesterolemia, but were withdrawn from the market due to toxicity caused by accumulation of desmosterol in tissues.
2816:
3868:"5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a potent inhibitor of sterol biosynthesis, lowers serum cholesterol and alters distributions of cholesterol in lipoproteins in baboons"
555:(though ultimately have never been marketed for this indication), and trilostane was formerly used to inhibit corticosteroid synthesis in the treatment of Cushing's syndrome.
680:
prevent the production of the potent mineralocorticoid aldosterone from the less potent mineralocorticoid corticosterone. Osilodrostat was investigated for the treatment of
583:
inhibit the production of androgens and glucocorticoids and are used to reduce androgen levels in the treatment of prostate cancer. Selective 17,20-lyase inhibitors such as
1003:
321:(FPP), a mid-range step in the biosynthesis of cholesterol from acetyl-CoA, and thereby inhibit cholesterol production. They notably do not significantly lower
325:
levels of cholesterol however, and hence, unlike statins, are not suitable for the treatment of hypercholesterolemia. The main examples of FPPS inhibitors are
217:
4902:
3827:"Inhibitors of sterol synthesis. Metabolism of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one after intravenous administration to bile duct-cannulated rats"
2976:
2792:
1365:
3812:"9α-hydroxy-3-oxo-4,24(25)-stigmastadien-26-oic acid derivatives, a process for preparing same and pharmaceutical compositions containing same"
1202:
826:
468:
1669:
4850:
4568:
4541:
4514:
4487:
4460:
4379:
4352:
4325:
4268:
4238:
4211:
4184:
4146:
4100:
4027:
4000:
3973:
3941:
3795:
3768:
3739:
3709:
261:
587:
inhibit only androgen production without affecting glucocorticoid synthesis and are under development for the treatment of prostate cancer.
4874:
399:
5325:
2596:
2072:
1682:
702:
5236:
5080:
5039:
4793:
Thomas MP, Potter BV (2015). "Estrogen O-sulfamates and their analogues: Clinical steroid sulfatase inhibitors with broad potential".
2383:
1306:
508:
2346:
1589:
5188:
5005:
4260:
Hormonal
Steroids Biochemistry, Pharmacology, and Therapeutics: Proceedings of the First International Congress on Hormonal Steroids
1070:
406:. 7-DHCR inhibitors produce an acquired form of SLOS in animals, and as such, like 24-DHCR inhibitors (see below), are probably too
5197:
3294:
2201:
2254:
1509:
5111:
4895:
2588:
1657:
1236:
1232:
1162:
415:
310:
1505:
1245:
5157:
5064:
3580:
3108:
3028:
1673:
1126:
770:
375:
2808:
5251:
5085:
3276:
2487:
2413:
906:
778:
5284:
5276:
4717:
Carlström K, Döberl A, Pousette A, Rannevik G, Wilking N (1984). "Inhibition of steroid sulfatase activity by danazol".
762:
3654:"Neurosteroids, GABAA receptors and neurosteroid based drugs: are we witnessing the dawn of the new psychiatric drugs?"
5180:
5170:
5152:
5093:
4997:
2442:
1601:
1417:
1080:
840:(SST) inhibitors prevent the conversion of steroid hormones such as estrone and DHEA into hormonally inactive steroid
257:
2552:
2209:
5034:
4976:
4939:
4888:
2556:
2536:
2409:
1787:
1717:
1713:
1496:
1488:
1484:
1476:
1336:
1332:
613:
605:
3606:
Vanden
Bossche H (1992). "Inhibitors of P450-dependent steroid biosynthesis: from research to medical treatment".
1931:
5123:
4989:
3014:
2544:
2401:
2241:
2189:
2181:
2177:
1088:
734:
391:
314:
3049:
5256:
5118:
3005:
2716:
2656:
1745:
837:
496:
3436:
3249:
2225:
4402:"Updates on the role of adrenal steroidogenesis inhibitors in Cushing's syndrome: a focus on novel therapies"
1249:
5231:
5209:
5175:
4934:
3440:
3388:
2872:
2003:
85:
1721:
487:
from cholesterol and thereby prevent the synthesis of all steroid hormones. They have been used to inhibit
5192:
5162:
5128:
5101:
5013:
4929:
3825:
Schroepfer GJ, Chu AJ, Needleman DH, Izumi A, Nguyen PT, Wang KS, Little JM, Sherrill BC, Kisic A (1988).
3112:
3024:
2900:
2090:
2007:
1886:
1783:
1492:
1340:
1228:
1224:
1092:
1084:
710:
653:
548:
318:
302:
4479:
Yen & Jaffe's
Reproductive Endocrinology E-Book: Physiology, Pathophysiology, and Clinical Management
2896:
2540:
5241:
3298:
3253:
3197:
2972:
2968:
2688:
2548:
2286:
1253:
982:
2491:
2233:
2217:
492:
3320:
2684:
3879:
3575:
3124:
3053:
2912:
2856:
2692:
2564:
2421:
2358:
2169:
2059:
1980:
1959:
1136:
845:
782:
665:
403:
387:
294:
3508:
2616:
5106:
5021:
3516:
3340:
3332:
3141:
3100:
2624:
2560:
2417:
2318:
2310:
2266:
2197:
1911:
1860:
1709:
1553:
1521:
1393:
1377:
986:
865:
802:
766:
758:
706:
564:
209:
4287:
Ray S, Sharma I (1987). "Development of progesterone antagonists as fertility regulating agents".
3556:
3552:
3456:
3396:
3372:
3368:
3316:
2628:
2322:
2165:
4944:
4818:
4742:
4658:
3631:
3544:
3492:
3488:
3424:
3404:
3352:
3324:
3312:
3133:
2964:
2960:
2956:
2952:
2932:
2820:
2519:
794:
3480:
3376:
2852:
2600:
2127:
1873:
1605:
3041:
1947:
5214:
4846:
4840:
4810:
4772:
4734:
4699:
4650:
4615:
4564:
4537:
4510:
4483:
4456:
4431:
4375:
4369:
4348:
4321:
4315:
4296:
4264:
4258:
4234:
4228:
4207:
4201:
4180:
4174:
4142:
4136:
4096:
4090:
4066:
4023:
4017:
3996:
3990:
3969:
3963:
3937:
3931:
3907:
3848:
3791:
3785:
3764:
3735:
3729:
3705:
3699:
3675:
3623:
3157:
3145:
3090:
3077:
2608:
2568:
2258:
2143:
2139:
2135:
2011:
1915:
1903:
1796:
1653:
1513:
1369:
1257:
1149:
869:
861:
806:
790:
714:
560:
472:
383:
274:
213:
194:
186:
70:
4558:
4531:
4504:
4477:
4450:
4342:
3758:
3169:
3153:
1725:
1649:
1541:
1193:
1145:
379:
4949:
4915:
4802:
4726:
4689:
4642:
4605:
4597:
4421:
4413:
4056:
3897:
3887:
3838:
3665:
3615:
3460:
3267:
3165:
3161:
3045:
2828:
2405:
2185:
2094:
2035:
1939:
1894:
1836:
1791:
1593:
1348:
1285:
991:
774:
657:
201:
127:
4763:
Sadozai H (2013). "Steroid sulfatase inhibitors: promising new therapy for breast cancer".
2868:
2864:
2860:
825:
inhibit the production of estrogens from androgens and are used mainly in the treatment of
233:
5219:
5026:
3210:
3116:
3036:
2523:
2515:
2495:
2298:
2245:
2229:
2193:
2098:
1500:
1360:
1344:
1117:
1113:
1109:
1105:
1101:
1097:
881:
785:
from progesterone, 11-deoxycorticosterone, and DHT, respectively, which may contribute to
500:
451:
443:
298:
150:
135:
2278:
2152:
888:
into their hormonally active forms. They have potential applications in the treatment of
543:
and thereby inhibit the production of most of the steroid hormones. Due to inhibition of
499:, and ketoconazole has also been used to inhibit androgen production in the treatment of
17:
4633:
Gibbs TT, Russek SJ, Farb DH (2006). "Sulfated steroids as endogenous neuromodulators".
3883:
5072:
5059:
4966:
4610:
4585:
4426:
4401:
3420:
2728:
2664:
2334:
2205:
2063:
1994:
1963:
1890:
1852:
1766:
1641:
1429:
1356:
1293:
1020:
996:
645:
597:
536:
488:
329:
270:
182:
178:
3902:
3867:
3843:
3826:
220:, steroidogenesis inhibitors directly inhibit the enzymatic biosynthesis of steroids.
5319:
5202:
3619:
3520:
3504:
3500:
3432:
3408:
3392:
3364:
3348:
2940:
2840:
2668:
2660:
2576:
2314:
1737:
1633:
1441:
958:
942:
893:
889:
829:
689:
685:
552:
212:; whereas antigonadotropins suppress gonadal production of sex steroids by effecting
75:
4822:
4746:
4662:
4911:
3635:
3548:
3528:
3512:
3496:
3472:
3464:
3452:
3448:
3428:
3416:
3400:
3380:
3356:
3344:
3308:
3263:
3222:
3218:
3206:
3128:
3073:
2936:
2920:
2812:
2776:
2772:
2756:
2636:
2612:
2527:
2511:
2282:
2274:
2249:
2237:
2173:
2102:
2055:
2043:
2015:
1971:
1935:
1832:
1812:
1779:
1757:
1749:
1665:
1625:
1613:
1585:
1545:
1480:
1472:
1449:
1437:
1433:
1413:
1352:
1328:
1324:
1281:
1240:
1057:
1049:
1029:
1025:
930:
922:
918:
910:
885:
853:
849:
822:
754:
718:
681:
677:
637:
625:
601:
576:
544:
484:
476:
447:
353:
286:
278:
277:(acetyl-CoA), and thereby decrease cholesterol levels. Examples of statins include
240:
190:
139:
94:
4880:
5049:
4806:
3540:
3536:
3532:
3524:
3484:
3476:
3444:
3412:
3360:
3245:
3202:
3193:
3104:
2928:
2924:
2888:
2880:
2876:
2800:
2768:
2752:
2740:
2708:
2572:
2467:
2455:
2451:
2438:
2366:
2350:
2342:
2330:
2302:
2294:
2270:
2262:
2221:
2131:
2051:
2031:
2027:
1998:
1907:
1864:
1856:
1828:
1800:
1733:
1729:
1661:
1637:
1581:
1549:
1525:
1517:
1421:
1389:
1381:
1373:
1269:
1261:
1220:
1181:
1176:
1172:
1140:
1061:
1053:
1037:
1033:
914:
810:
786:
750:
746:
742:
738:
649:
617:
584:
540:
520:
512:
455:
427:
419:
362:
349:
345:
341:
337:
333:
326:
290:
237:
174:
162:
154:
3933:
Metabolic
Diseases: Foundations of Clinical Management, Genetics, and Pathology
4730:
4646:
4417:
3811:
3468:
3336:
3328:
3302:
3290:
2884:
2836:
2832:
2804:
2796:
2760:
2736:
2724:
2720:
2652:
2644:
2640:
2620:
2604:
2592:
2584:
2503:
2463:
2459:
2447:
2426:
2370:
2354:
2326:
2306:
2047:
2019:
1967:
1951:
1943:
1844:
1840:
1804:
1645:
1629:
1617:
1609:
1577:
1573:
1533:
1529:
1445:
1425:
1409:
1297:
1189:
1153:
1045:
1041:
954:
938:
934:
926:
814:
669:
629:
572:
532:
439:
423:
282:
244:
143:
39:
4070:
3679:
5142:
4061:
4044:
3670:
3653:
3384:
3257:
3214:
3149:
3081:
3065:
2997:
2993:
2989:
2916:
2908:
2892:
2848:
2844:
2824:
2788:
2784:
2780:
2748:
2732:
2704:
2680:
2676:
2672:
2648:
2632:
2580:
2531:
2507:
2474:
2434:
2362:
2338:
2110:
2039:
2023:
1927:
1923:
1919:
1848:
1824:
1820:
1808:
1741:
1704:
1621:
1597:
1569:
1565:
1561:
1537:
1405:
1277:
1265:
1185:
962:
873:
818:
726:
621:
580:
568:
4814:
4776:
4703:
4654:
4619:
4435:
3892:
3627:
4869:
4738:
4300:
3911:
3866:
Schroepfer GJ, Parish EJ, Kisic A, Jackson EM, Farley CM, Mott GE (1982).
3852:
106:
4601:
3061:
2985:
2948:
2944:
2764:
2744:
2700:
2696:
2430:
2290:
2213:
1955:
1898:
1816:
1753:
1700:
1401:
1385:
1289:
950:
673:
641:
633:
528:
524:
516:
480:
170:
166:
4694:
4677:
4019:
Tietz
Textbook of Clinical Chemistry and Molecular Diagnostics - E-Book
3178:
3137:
3120:
3069:
3032:
2904:
2712:
2499:
2123:
2119:
2115:
2106:
1557:
1458:
1397:
1273:
1016:
941:. Ergosterol is absent in animals but is an essential component of the
877:
841:
722:
146:
90:
52:
4981:
4016:
Carl A. Burtis; Edward R. Ashwood; David E. Bruns (14 October 2012).
3231:
977:
158:
131:
78:
600:(CYP21A2) inhibitors prevent the production of corticosteroids from
4341:
William D. Figg; Cindy H. Chau; Eric J. Small (14 September 2010).
5266:
3057:
946:
660:
and are used in the diagnosis and treatment of
Cushing's syndrome.
438:
407:
273:, a relatively early step in the biosynthesis of cholesterol from
205:
3965:
Cholesterol: Its
Functions and Metabolism in Biology and Medicine
3930:
E. Gilbert-Barness; L.A. Barness; P.M. Farrell (6 January 2017).
3728:
Frank J. Dowd; Bart
Johnson; Angelo Mariotti (3 September 2016).
2980:
2374:
395:
123:
4884:
4586:"The Regulation of Steroid Action by Sulfation and Desulfation"
4584:
Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA (2015).
4227:
Waun Ki Hong; American
Association for Cancer Research (2010).
844:. Although hormonally inactive, some steroid sulfates, such as
1203:
200:
Steroidogenesis inhibitors are analogous in effect and use to
3925:
3923:
3921:
3787:
General and
Molecular Pharmacology: Principles of Drug Action
896:, and are currently under investigation for such indications.
262:
4317:
Cushing's Syndrome: Pathophysiology, Diagnosis and Treatment
953:, and so lanosterol 14α-demethylase inhibitors are used as
57:
Steroid biosynthesis inhibitor; Steroid synthesis inhibitor
4200:
Dimitrios A. Linos; Jon A. van Heerden (5 December 2005).
4536:. Springer Science & Business Media. pp. 46–50.
4347:. Springer Science & Business Media. pp. 96–98.
1071:
692:, but development for these indications was discontinued.
4476:
Jerome F. Strauss; Robert L. Barbieri (28 August 2013).
4320:. Springer Science & Business Media. pp. 157–.
4206:. Springer Science & Business Media. pp. 171–.
3968:. Springer Science & Business Media. pp. 130–.
2073:
1683:
361:
Other early-stage cholesterol synthesis inhibitors like
4509:. Springer Science & Business Media. pp. 79–.
4455:. Springer Science & Business Media. pp. 39–.
4203:
Adrenal Glands: Diagnostic Aspects and Surgical Therapy
4176:
Cytochrome P450: Structure, Mechanism, and Biochemistry
4092:
Principles and Practice of Endocrinology and Metabolism
3784:
Francesco Clementi; Guido Fumagalli (9 February 2015).
2384:
1307:
1163:
1127:
1081:
Dimethylallyl pyrophosphate (isoprenyl pyrophosphate)
640:
inhibit the production of the potent corticosteroids
390:, one of the last steps in cholesterol biosynthesis.
4135:
J. Larry Jameson; Leslie J. De Groot (18 May 2010).
4095:. Lippincott Williams & Wilkins. pp. 735–.
3731:
Pharmacology and Therapeutics for Dentistry - E-Book
5293:
5265:
5141:
5048:
4965:
4958:
4922:
4130:
4128:
4126:
4124:
4122:
4120:
4118:
4116:
4114:
4112:
3647:
3645:
880:inhibit the conversion of steroid sulfates such as
260:, also known as statins, prevent the conversion of
100:
84:
69:
61:
51:
46:
32:
4845:. Jones & Bartlett Publishers. pp. 292–.
4839:Tekoa L. King; Mary C. Brucker (25 October 2010).
4834:
4832:
4045:"Diagram of the pathways of human steroidogenesis"
208:sex steroid production), but work via a different
4168:
4166:
4164:
4162:
4160:
4158:
3723:
3721:
3015:
463:Non-specific steroid hormone synthesis inhibitors
193:. They are used in the treatment of a variety of
3006:
561:17α-Hydroxylase/17,20-lyase (CYP17A1) inhibitors
4788:
4786:
4758:
4756:
4506:Female Alopecia: Guide to Successful Management
4395:
4393:
4391:
3763:. Elsevier Science. 17 May 2017. pp. 88–.
3693:
3691:
3689:
2004:18-Ethynylprogesterone (18-ethinylprogesterone)
4282:
4280:
4252:
4250:
4141:. Elsevier Health Sciences. pp. 301–302.
3957:
3955:
3953:
3753:
3751:
3701:Comprehensive Dermatologic Drug Therapy E-Book
3601:
3599:
3597:
3595:
1208:Tooltip Cholesterol side-chain cleavage enzyme
4896:
4173:Paul R. Ortiz de Montellano (13 March 2015).
4084:
4082:
4080:
547:biosynthesis, they have been investigated as
267:Tooltip 3-hydroxy-3-methylglutaryl-coenzyme A
8:
4482:. Elsevier Health Sciences. pp. 81–82.
3760:Nuclear Receptors in Development and Disease
592:Corticosteroid-specific synthesis inhibitors
313:(FPPS) inhibitors prevent the conversion of
4138:Endocrinology - E-Book: Adult and Pediatric
4022:. Elsevier Health Sciences. pp. 733–.
3734:. Elsevier Health Sciences. pp. 426–.
3704:. Elsevier Health Sciences. pp. 415–.
3295:4,4-Dimethylcholesta-8(9),14,24-trien-3β-ol
426:inhibit the production of cholesterol from
386:inhibit the production of cholesterol from
4962:
4903:
4889:
4881:
4693:
4609:
4425:
4060:
3901:
3891:
3842:
3669:
3091:
1076:Tooltip Farnesyl pyrophosphate synthetase
697:Sex steroid-specific synthesis inhibitors
4314:Marcello D. Bronstein (1 October 2010).
3790:. John Wiley & Sons. pp. 442–.
3698:Stephen E. Wolverton (18 October 2012).
3652:Tvrdeić, Ante; Poljak, Ljiljana (2016).
3150:Irosustat (STX64, 667 Coumate, BN-83495)
2078:Tooltip 17β-Hydroxysteroid dehydrogenase
1688:Tooltip 11β-Hydroxysteroid dehydrogenase
973:
297:for the purpose of lowering the risk of
232:
4676:Prough RA, Clark BJ, Klinge CM (2016).
3992:Advances in Lipid Research: Skin Lipids
3591:
2389:Tooltip 3α-Hydroxysteroid dehydrogenase
1312:Tooltip 3β-Hydroxysteroid dehydrogenase
1168:Tooltip 24-Dehydrocholesterol reductase
761:(DHT) and are used in the treatment of
4452:Regulation of Aldosterone Biosynthesis
1132:Tooltip 7-Dehydrocholesterol reductase
771:inhibit the formation of neurosteroids
769:(pattern hair loss). These drugs also
471:(P450scc, CYP11A1) inhibitors such as
469:Cholesterol side-chain cleavage enzyme
29:
970:List of steroid metabolism modulators
652:from the less potent corticosteroids
352:, which are used in the treatment of
153:. They may inhibit the production of
7:
4560:Endocrine Therapies in Breast Cancer
4368:Stephen Neidle (30 September 2013).
435:Steroid hormone synthesis inhibitors
402:(SLOS) and dramatic accumulation of
370:Lanosterol to cholesterol inhibitors
293:. They are used in the treatment of
258:HMG-CoA reductase (HMGCR) inhibitors
197:that depend on endogenous steroids.
134:that are involved in the process of
4503:Ralph M. Trüeb (26 February 2013).
3962:Robert Bittman (11 November 2013).
252:Acetyl-CoA to lanosterol inhibitors
218:hypothalamic–pituitary–gonadal axis
4678:"Novel mechanisms for DHEA action"
4557:Aman U. Buzdar (8 November 2007).
4344:Drug Management of Prostate Cancer
3989:Peter M. Elias (21 January 2016).
901:Other steroid synthesis inhibitors
25:
4400:Fleseriu M, Castinetti F (2016).
4374:. Academic Press. pp. 341–.
4043:Häggström M, Richfield D (2014).
3658:Endocrine Oncology and Metabolism
3050:2,6-Dichloro-4-nitrophenol (DCNP)
3020:Tooltip Estrogen sulfotransferase
709:conversion of the weak androgens
705:(17β-HSD) inhibitors prevent the
4868:
4530:Rob Bradbury (30 January 2007).
4371:Cancer Drug Design and Discovery
3011:Tooltip Steroid sulfotransferase
2881:Rogletimide (pyridoglutethimide)
1750:Glycyrrhizin (glycyrrhizic acid)
703:17β-Hydroxysteroid dehydrogenase
229:Cholesterol synthesis inhibitors
4842:Pharmacology for Women's Health
4719:Acta Obstet Gynecol Scand Suppl
4449:Jürg Müller (6 December 2012).
3936:. IOS Press. pp. 336–337.
1742:Enoxolone (glycyrrhetinic acid)
535:inhibit the conversion of Δ-3β-
509:3β-Hydroxysteroid dehydrogenase
416:24-Dehydrocholesterol reductase
311:Farnesyl pyrophosphate synthase
216:on and thereby suppressing the
4563:. OUP Oxford. pp. 37–40.
4230:Holland-Frei Cancer Medicine 8
4179:. Springer. pp. 851–879.
3581:Neurosteroidogenesis inhibitor
3109:Dehydroepiandrosterone sulfate
3029:Dehydroepiandrosterone sulfate
757:into the more potent androgen
725:into the more potent estrogen
717:into the more potent androgen
491:synthesis in the treatment of
376:7-Dehydrocholesterol reductase
120:steroid biosynthesis inhibitor
1:
4795:J. Steroid Biochem. Mol. Biol
4257:L Martini (2 December 2012).
3844:10.1016/S0021-9258(18)68897-0
3608:J. Steroid Biochem. Mol. Biol
2202:5α-Dihydrodeoxycorticosterone
909:(CYP51A1) inhibitors such as
779:tetrahydrodeoxycorticosterone
668:(CYP11B2) inhibitors such as
616:(CYP11B1) inhibitors such as
418:(24-DHCR) inhibitors such as
3872:Proc. Natl. Acad. Sci. U.S.A
3620:10.1016/0960-0760(92)90328-G
3142:Estradiol sulfamate (E2MATE)
1237:20α,22R-Dihydroxycholesterol
1233:20α,22R-Dihydroxycholesterol
763:benign prostatic hyperplasia
511:(3β-HSD) inhibitors such as
378:(7-DHCR) inhibitors such as
204:(which specifically inhibit
4807:10.1016/j.jsbmb.2015.03.012
4263:. Elsevier. pp. 383–.
4233:. PMPH-USA. pp. 756–.
3995:. Elsevier. pp. 218–.
2443:Medroxyprogesterone acetate
1418:Medroxyprogesterone acetate
5342:
5326:Steroidogenesis inhibitors
5081:Dihydropteroate synthetase
4940:Non-competitive inhibition
4875:Steroidogenesis inhibitors
4089:Kenneth L. Becker (2001).
3533:Terconazole (triaconazole)
2488:16α-Hydroxyandrostenedione
933:prevent the production of
907:Lanosterol 14α-demethylase
827:estrogen receptor-positive
753:prevent the conversion of
483:inhibit the production of
400:Smith–Lemli–Opitz syndrome
398:encoding 7-DHCR result in
392:Loss-of-function mutations
5301:Steroidogenesis inhibitor
4731:10.3109/00016348409156994
4647:10.1016/j.pbb.2006.07.031
4635:Pharmacol. Biochem. Behav
4418:10.1007/s11102-016-0742-1
3146:Estrone sulfamate (EMATE)
3096:Tooltip Steroid sulfatase
1089:Isopentenyl pyrophosphate
864:(STS) inhibitors such as
315:isopentenyl pyrophosphate
224:Types, examples, and uses
116:steroidogenesis inhibitor
105:
37:
33:Steroidogenesis inhibitor
18:Steroidogenesis modulator
5237:Matrix metalloproteinase
5040:Ribonucleotide reductase
4935:Uncompetitive inhibition
3437:Isavuconazonium chloride
2873:Resorcylic acid lactones
2657:conjugated linoleic acid
2210:5α-Dihydrocorticosterone
1746:Epigallocatechin gallate
838:Steroid sulfotransferase
497:adrenocortical carcinoma
5006:Dihydrofolate reductase
4049:WikiJournal of Medicine
3441:Isavuconazonium sulfate
3389:Econazole/triamcinolone
3078:Pentachlorophenol (PCP)
2557:20α-Dihydroprogesterone
1788:17α-Hydroxyprogesterone
1718:11β-Hydroxyprogesterone
1714:11α-Hydroxyprogesterone
1497:17α-Hydroxyprogesterone
1489:17α-Hydroxypregnenolone
1485:17α-Hydroxyprogesterone
1477:17α-Hydroxypregnenolone
1337:17α-Hydroxyprogesterone
1333:17α-Hydroxypregnenolone
1250:3,3′-Dimethoxybenzidine
735:5α-Reductase inhibitors
606:17α-hydroxyprogesterone
5102:Nucleotidyltransferase
4930:Competitive inhibition
3893:10.1073/pnas.79.9.3042
3113:Dehydroepiandrosterone
3025:Dehydroepiandrosterone
2545:4'-Hydroxynorendoxifen
2402:5α-Dihydroprogesterone
2242:5α-Dihydrotestosterone
2190:3β-Dihydroprogesterone
2182:3α-Dihydroprogesterone
2178:5α-Dihydroprogesterone
2091:Dehydroepiandrosterone
1887:11-Deoxycorticosterone
1784:11-Deoxycorticosterone
1493:Dehydroepiandrosterone
1341:Dehydroepiandrosterone
1229:22R-Hydroxycholesterol
1225:22R-Hydroxycholesterol
1093:Farnesyl pyrophosphate
1085:Farnesyl pyrophosphate
721:and the weak estrogen
711:dehydroepiandrosterone
654:11-deoxycorticosterone
459:
410:to be used clinically.
319:farnesyl pyrophosphate
303:cardiovascular disease
248:
5112:Reverse transcriptase
4062:10.15347/wjm/2014.005
3671:10.21040/eom/2016.2.7
3250:7α-Hydroxycholesterol
3198:27-Hydroxycholesterol
2549:4-Hydroxytestosterone
2287:Chlormadinone acetate
2226:5α-Dihydroaldosterone
1722:18α-Glycyrrhizic acid
442:
236:
5158:Acetylcholinesterase
5065:Thymidylate synthase
4877:at Wikimedia Commons
4602:10.1210/er.2015-1036
3576:Steroidogenic enzyme
3125:Pregnenolone sulfate
3054:7,8-Dihydroxyflavone
2901:(–)-dehydrololiolide
2565:alpha-Naphthoflavone
2359:Saw palmetto extract
2060:Potassium canrenoate
2008:18-Vinylprogesterone
1960:Potassium canrenoate
1137:7-Dehydrocholesterol
961:in the treatment of
846:pregnenolone sulfate
803:Aromatase inhibitors
666:Aldosterone synthase
404:7-dehydrocholesterol
388:7-dehydrocholesterol
295:hypercholesterolemia
5252:Histone deacetylase
5086:Farnesyltransferase
4695:10.1530/JME-16-0013
3884:1982PNAS...79.3042S
3101:Cholesterol sulfate
2897:dehydroabietic acid
2829:PGE2 (dinoprostone)
2541:4-Cyclohexylaniline
2418:Dihydrotestosterone
2267:Abiraterone acetate
2198:Deoxycorticosterone
1912:Abiraterone acetate
1861:Abiraterone acetate
1710:11-Ketoprogesterone
1554:Cyproterone acetate
1522:Abiraterone acetate
1394:Cyproterone acetate
1378:Abiraterone acetate
866:estradiol sulfamate
767:androgenic alopecia
759:dihydrotestosterone
565:abiraterone acetate
210:mechanism of action
130:one or more of the
5285:Carbonic anhydrase
5277:Dopa decarboxylase
4945:Suicide inhibition
4682:J. Mol. Endocrinol
2973:monodictyochrome B
2969:monodictyochrome A
2689:7-hydroxyflavanone
2520:Methyltestosterone
2492:16α-Hydroxyestrone
2234:5α-Androstanedione
2218:5α-Dihydrocortisol
1254:3-Methoxybenzidine
795:sexual dysfunction
493:Cushing's syndrome
460:
249:
195:medical conditions
187:mineralocorticoids
118:, also known as a
5313:
5312:
5309:
5308:
5181:Alpha-glucosidase
5171:Polygalacturonase
5153:Phosphodiesterase
5094:GABA transaminase
4998:Monoamine oxidase
4982:HMG-CoA reductase
4916:enzyme inhibition
4873:Media related to
4852:978-1-4496-5800-7
4570:978-0-19-921814-1
4543:978-3-540-33120-9
4516:978-3-642-35503-5
4489:978-1-4557-5972-9
4462:978-3-642-96062-8
4381:978-0-12-397228-6
4354:978-1-60327-829-4
4327:978-1-60327-449-4
4270:978-0-323-14465-0
4240:978-1-60795-014-1
4213:978-3-540-26861-1
4186:978-3-319-12108-6
4148:978-1-4557-1126-0
4102:978-0-7817-1750-2
4029:978-1-4557-5942-2
4002:978-1-4832-1545-7
3975:978-1-4615-5901-6
3943:978-1-61499-718-4
3797:978-1-118-76857-0
3770:978-0-12-802196-5
3741:978-0-323-44595-5
3711:978-1-4557-3801-4
3564:
3563:
3287:
3242:
3190:
2609:isoliquiritigenin
2569:Aminoglutethimide
2484:
2422:3α-Androstanediol
2398:
2162:
2087:
2012:Aminoglutethimide
1991:
1916:Aminoglutethimide
1883:
1797:Aminoglutethimide
1776:
1697:
1469:
1321:
1258:Aminoglutethimide
1217:
1013:
1004:HMG-CoA reductase
870:estrone sulfamate
862:Steroid sulfatase
807:aminoglutethimide
783:3α-androstanediol
737:(5-ARIs) such as
715:4-androstenedione
473:aminoglutethimide
275:acetyl coenzyme A
214:negative feedback
202:antigonadotropins
112:
111:
71:Biological target
47:Class identifiers
16:(Redirected from
5333:
5035:Xanthine oxidase
4977:Aldose reductase
4963:
4950:Mixed inhibition
4905:
4898:
4891:
4882:
4872:
4857:
4856:
4836:
4827:
4826:
4790:
4781:
4780:
4760:
4751:
4750:
4714:
4708:
4707:
4697:
4673:
4667:
4666:
4630:
4624:
4623:
4613:
4581:
4575:
4574:
4554:
4548:
4547:
4527:
4521:
4520:
4500:
4494:
4493:
4473:
4467:
4466:
4446:
4440:
4439:
4429:
4397:
4386:
4385:
4365:
4359:
4358:
4338:
4332:
4331:
4311:
4305:
4304:
4284:
4275:
4274:
4254:
4245:
4244:
4224:
4218:
4217:
4197:
4191:
4190:
4170:
4153:
4152:
4132:
4107:
4106:
4086:
4075:
4074:
4064:
4040:
4034:
4033:
4013:
4007:
4006:
3986:
3980:
3979:
3959:
3948:
3947:
3927:
3916:
3915:
3905:
3895:
3863:
3857:
3856:
3846:
3822:
3816:
3815:
3808:
3802:
3801:
3781:
3775:
3774:
3755:
3746:
3745:
3725:
3716:
3715:
3695:
3684:
3683:
3673:
3649:
3640:
3639:
3603:
3461:Levoketoconazole
3321:Arasertaconazole
3281:
3268:Levoketoconazole
3236:
3184:
3097:
3093:
3046:6-Hydroxyflavone
3021:
3017:
3012:
3008:
2685:7-hydroxyflavone
2478:
2406:Allopregnanolone
2392:
2390:
2386:
2319:γ-linolenic acid
2311:α-linolenic acid
2186:Allopregnanolone
2156:
2095:5-Androstenediol
2081:
2079:
2075:
1985:
1940:Levoketoconazole
1895:11-Deoxycortisol
1877:
1837:Levoketoconazole
1792:11-Deoxycortisol
1770:
1691:
1689:
1685:
1594:Levoketoconazole
1463:
1459:17α-Hydroxylase,
1349:5-Androstenediol
1315:
1313:
1309:
1286:Levoketoconazole
1211:
1209:
1205:
1169:
1165:
1133:
1129:
1077:
1073:
1007:
974:
852:, are important
775:allopregnanolone
658:11-deoxycortisol
452:steroid hormones
268:
264:
151:steroid hormones
30:
21:
5341:
5340:
5336:
5335:
5334:
5332:
5331:
5330:
5316:
5315:
5314:
5305:
5289:
5261:
5137:
5124:Tyrosine kinase
5044:
4954:
4918:
4909:
4865:
4860:
4853:
4838:
4837:
4830:
4792:
4791:
4784:
4765:J Pak Med Assoc
4762:
4761:
4754:
4716:
4715:
4711:
4675:
4674:
4670:
4632:
4631:
4627:
4583:
4582:
4578:
4571:
4556:
4555:
4551:
4544:
4529:
4528:
4524:
4517:
4502:
4501:
4497:
4490:
4475:
4474:
4470:
4463:
4448:
4447:
4443:
4399:
4398:
4389:
4382:
4367:
4366:
4362:
4355:
4340:
4339:
4335:
4328:
4313:
4312:
4308:
4286:
4285:
4278:
4271:
4256:
4255:
4248:
4241:
4226:
4225:
4221:
4214:
4199:
4198:
4194:
4187:
4172:
4171:
4156:
4149:
4134:
4133:
4110:
4103:
4088:
4087:
4078:
4042:
4041:
4037:
4030:
4015:
4014:
4010:
4003:
3988:
3987:
3983:
3976:
3961:
3960:
3951:
3944:
3929:
3928:
3919:
3865:
3864:
3860:
3824:
3823:
3819:
3810:
3809:
3805:
3798:
3783:
3782:
3778:
3771:
3757:
3756:
3749:
3742:
3727:
3726:
3719:
3712:
3697:
3696:
3687:
3651:
3650:
3643:
3605:
3604:
3593:
3589:
3572:
3566:
3279:14α-demethylase
3278:
3233:
3211:Dexmedetomidine
3183:
3180:
3117:Estrone sulfate
3095:
3037:Estrone sulfate
3019:
3010:
2857:triptoquinone A
2524:Methylestradiol
2516:Methylestradiol
2496:Androstenedione
2477:
2391:
2388:
2299:Epitestosterone
2246:Androstadienone
2230:Androstenedione
2194:Isopregnanolone
2170:5α-Cholestanone
2155:
2099:Androstenedione
2080:
2077:
1982:
1876:
1874:11β-Hydroxylase
1769:
1690:
1687:
1501:Androstenedione
1460:
1361:Androstadienone
1345:Androstenedione
1314:
1311:
1210:
1207:
1167:
1131:
1118:Zoledronic acid
1114:Risedronic acid
1110:Pamidronic acid
1106:Incadronic acid
1102:Ibandronic acid
1098:Alendronic acid
1075:
1006:
972:
903:
882:estrone sulfate
699:
614:11β-Hydroxylase
594:
537:hydroxysteroids
501:prostate cancer
465:
444:Steroidogenesis
437:
372:
330:bisphosphonates
299:atherosclerosis
266:
254:
231:
226:
183:glucocorticoids
179:corticosteroids
136:steroidogenesis
122:, is a type of
28:
23:
22:
15:
12:
11:
5:
5339:
5337:
5329:
5328:
5318:
5317:
5311:
5310:
5307:
5306:
5304:
5303:
5297:
5295:
5291:
5290:
5288:
5287:
5280:
5279:
5272:
5270:
5263:
5262:
5260:
5259:
5257:Beta-lactamase
5254:
5247:
5246:
5245:
5244:
5239:
5234:
5224:
5223:
5222:
5217:
5207:
5206:
5205:
5200:
5184:
5183:
5178:
5173:
5166:
5165:
5160:
5155:
5148:
5146:
5139:
5138:
5136:
5135:
5134:
5133:
5132:
5131:
5119:Protein kinase
5116:
5115:
5114:
5109:
5097:
5096:
5089:
5088:
5083:
5076:
5075:
5068:
5067:
5062:
5055:
5053:
5046:
5045:
5043:
5042:
5037:
5030:
5029:
5024:
5017:
5016:
5009:
5008:
5001:
5000:
4993:
4992:
4985:
4984:
4979:
4972:
4970:
4967:Oxidoreductase
4960:
4956:
4955:
4953:
4952:
4947:
4942:
4937:
4932:
4926:
4924:
4920:
4919:
4910:
4908:
4907:
4900:
4893:
4885:
4879:
4878:
4864:
4863:External links
4861:
4859:
4858:
4851:
4828:
4782:
4752:
4709:
4688:(3): R139–55.
4668:
4625:
4576:
4569:
4549:
4542:
4522:
4515:
4495:
4488:
4468:
4461:
4441:
4412:(6): 643–653.
4387:
4380:
4360:
4353:
4333:
4326:
4306:
4295:(10): 656–61.
4276:
4269:
4246:
4239:
4219:
4212:
4192:
4185:
4154:
4147:
4108:
4101:
4076:
4035:
4028:
4008:
4001:
3981:
3974:
3949:
3942:
3917:
3858:
3837:(9): 4110–23.
3817:
3803:
3796:
3776:
3769:
3747:
3740:
3717:
3710:
3685:
3641:
3614:(8): 1003–21.
3590:
3588:
3585:
3584:
3583:
3578:
3571:
3568:
3562:
3561:
3559:
3509:Quilseconazole
3421:Fosfluconazole
3306:
3288:
3273:
3272:
3270:
3261:
3243:
3234:7α-hydroxylase
3228:
3227:
3225:
3200:
3191:
3181:27-hydroxylase
3175:
3174:
3172:
3131:
3098:
3087:
3086:
3084:
3039:
3022:
3002:
3001:
2983:
2729:liquiritigenin
2665:linolenic acid
2617:Corynesidone A
2534:
2485:
2471:
2470:
2445:
2424:
2399:
2380:
2379:
2377:
2335:Ganoderic acid
2252:
2206:Corticosterone
2163:
2149:
2148:
2146:
2113:
2088:
2069:
2068:
2066:
2064:Spironolactone
2001:
1995:Corticosterone
1992:
1977:
1976:
1974:
1964:Spironolactone
1901:
1891:Corticosterone
1884:
1870:
1869:
1867:
1853:Spironolactone
1794:
1777:
1767:21-Hydroxylase
1763:
1762:
1760:
1707:
1698:
1679:
1678:
1676:
1642:Spironolactone
1503:
1470:
1455:
1454:
1452:
1430:Norethisterone
1363:
1357:Androstadienol
1322:
1303:
1302:
1300:
1294:Spironolactone
1243:
1218:
1199:
1198:
1196:
1179:
1170:
1159:
1158:
1156:
1143:
1134:
1123:
1122:
1120:
1095:
1078:
1067:
1066:
1064:
1023:
1021:Mevalonic acid
1014:
1000:
999:
994:
989:
980:
971:
968:
967:
966:
959:antiprotozoals
943:cell membranes
902:
899:
898:
897:
858:
857:
834:
833:
805:(AIs) such as
799:
798:
731:
730:
698:
695:
694:
693:
662:
661:
646:corticosterone
610:
609:
598:21-Hydroxylase
593:
590:
589:
588:
557:
556:
553:abortifacients
549:contraceptives
505:
504:
489:corticosteroid
464:
461:
436:
433:
432:
431:
412:
411:
371:
368:
367:
366:
358:
357:
307:
306:
271:mevalonic acid
253:
250:
230:
227:
225:
222:
110:
109:
103:
102:
98:
97:
88:
86:Chemical class
82:
81:
73:
67:
66:
63:
59:
58:
55:
49:
48:
44:
43:
35:
34:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5338:
5327:
5324:
5323:
5321:
5302:
5299:
5298:
5296:
5294:Miscellaneous
5292:
5286:
5282:
5281:
5278:
5274:
5273:
5271:
5268:
5264:
5258:
5255:
5253:
5249:
5248:
5243:
5240:
5238:
5235:
5233:
5232:Enkephalinase
5230:
5229:
5228:
5225:
5221:
5218:
5216:
5213:
5212:
5211:
5210:Endopeptidase
5208:
5204:
5201:
5199:
5196:
5195:
5194:
5190:
5186:
5185:
5182:
5179:
5177:
5176:Neuraminidase
5174:
5172:
5168:
5167:
5164:
5161:
5159:
5156:
5154:
5150:
5149:
5147:
5144:
5140:
5130:
5127:
5126:
5125:
5122:
5121:
5120:
5117:
5113:
5110:
5108:
5105:
5104:
5103:
5099:
5098:
5095:
5091:
5090:
5087:
5084:
5082:
5078:
5077:
5074:
5070:
5069:
5066:
5063:
5061:
5057:
5056:
5054:
5051:
5047:
5041:
5038:
5036:
5032:
5031:
5028:
5025:
5023:
5019:
5018:
5015:
5011:
5010:
5007:
5003:
5002:
4999:
4995:
4994:
4991:
4987:
4986:
4983:
4980:
4978:
4974:
4973:
4971:
4968:
4964:
4961:
4957:
4951:
4948:
4946:
4943:
4941:
4938:
4936:
4933:
4931:
4928:
4927:
4925:
4921:
4917:
4913:
4906:
4901:
4899:
4894:
4892:
4887:
4886:
4883:
4876:
4871:
4867:
4866:
4862:
4854:
4848:
4844:
4843:
4835:
4833:
4829:
4824:
4820:
4816:
4812:
4808:
4804:
4800:
4796:
4789:
4787:
4783:
4778:
4774:
4771:(4): 509–15.
4770:
4766:
4759:
4757:
4753:
4748:
4744:
4740:
4736:
4732:
4728:
4724:
4720:
4713:
4710:
4705:
4701:
4696:
4691:
4687:
4683:
4679:
4672:
4669:
4664:
4660:
4656:
4652:
4648:
4644:
4641:(4): 555–67.
4640:
4636:
4629:
4626:
4621:
4617:
4612:
4607:
4603:
4599:
4596:(5): 526–63.
4595:
4591:
4587:
4580:
4577:
4572:
4566:
4562:
4561:
4553:
4550:
4545:
4539:
4535:
4534:
4526:
4523:
4518:
4512:
4508:
4507:
4499:
4496:
4491:
4485:
4481:
4480:
4472:
4469:
4464:
4458:
4454:
4453:
4445:
4442:
4437:
4433:
4428:
4423:
4419:
4415:
4411:
4407:
4403:
4396:
4394:
4392:
4388:
4383:
4377:
4373:
4372:
4364:
4361:
4356:
4350:
4346:
4345:
4337:
4334:
4329:
4323:
4319:
4318:
4310:
4307:
4302:
4298:
4294:
4290:
4283:
4281:
4277:
4272:
4266:
4262:
4261:
4253:
4251:
4247:
4242:
4236:
4232:
4231:
4223:
4220:
4215:
4209:
4205:
4204:
4196:
4193:
4188:
4182:
4178:
4177:
4169:
4167:
4165:
4163:
4161:
4159:
4155:
4150:
4144:
4140:
4139:
4131:
4129:
4127:
4125:
4123:
4121:
4119:
4117:
4115:
4113:
4109:
4104:
4098:
4094:
4093:
4085:
4083:
4081:
4077:
4072:
4068:
4063:
4058:
4054:
4050:
4046:
4039:
4036:
4031:
4025:
4021:
4020:
4012:
4009:
4004:
3998:
3994:
3993:
3985:
3982:
3977:
3971:
3967:
3966:
3958:
3956:
3954:
3950:
3945:
3939:
3935:
3934:
3926:
3924:
3922:
3918:
3913:
3909:
3904:
3899:
3894:
3889:
3885:
3881:
3878:(9): 3042–6.
3877:
3873:
3869:
3862:
3859:
3854:
3850:
3845:
3840:
3836:
3832:
3831:J. Biol. Chem
3828:
3821:
3818:
3813:
3807:
3804:
3799:
3793:
3789:
3788:
3780:
3777:
3772:
3766:
3762:
3761:
3754:
3752:
3748:
3743:
3737:
3733:
3732:
3724:
3722:
3718:
3713:
3707:
3703:
3702:
3694:
3692:
3690:
3686:
3681:
3677:
3672:
3667:
3663:
3659:
3655:
3648:
3646:
3642:
3637:
3633:
3629:
3625:
3621:
3617:
3613:
3609:
3602:
3600:
3598:
3596:
3592:
3586:
3582:
3579:
3577:
3574:
3573:
3569:
3567:
3560:
3558:
3554:
3550:
3546:
3542:
3538:
3534:
3530:
3526:
3522:
3521:Sertaconazole
3518:
3517:Saperconazole
3514:
3510:
3506:
3505:Pramiconazole
3502:
3501:Propiconazole
3498:
3494:
3490:
3486:
3482:
3478:
3474:
3470:
3466:
3462:
3458:
3454:
3450:
3446:
3442:
3438:
3434:
3433:Isavuconazole
3430:
3426:
3422:
3418:
3414:
3410:
3409:Fenticonazole
3406:
3402:
3398:
3394:
3393:Efinaconazole
3390:
3386:
3382:
3378:
3374:
3370:
3366:
3365:Cyproconazole
3362:
3358:
3354:
3350:
3349:Chlormidazole
3346:
3342:
3341:Brolaconazole
3338:
3334:
3333:Becliconazole
3330:
3326:
3322:
3318:
3314:
3310:
3307:
3304:
3300:
3296:
3292:
3289:
3285:
3280:
3275:
3274:
3271:
3269:
3265:
3262:
3259:
3255:
3251:
3247:
3244:
3240:
3235:
3230:
3229:
3226:
3224:
3220:
3216:
3212:
3208:
3204:
3201:
3199:
3195:
3192:
3188:
3182:
3177:
3176:
3173:
3171:
3167:
3163:
3159:
3155:
3151:
3147:
3143:
3139:
3135:
3132:
3130:
3126:
3122:
3118:
3114:
3110:
3106:
3102:
3099:
3094:
3089:
3088:
3085:
3083:
3079:
3075:
3071:
3067:
3063:
3059:
3055:
3051:
3047:
3043:
3040:
3038:
3034:
3030:
3026:
3023:
3018:
3009:
3004:
3003:
2999:
2995:
2991:
2987:
2984:
2982:
2978:
2974:
2970:
2966:
2962:
2958:
2954:
2950:
2946:
2942:
2941:Valproic acid
2938:
2934:
2930:
2926:
2922:
2918:
2914:
2910:
2906:
2902:
2898:
2894:
2890:
2886:
2882:
2878:
2874:
2870:
2866:
2862:
2858:
2854:
2850:
2846:
2842:
2841:Propiconazole
2838:
2834:
2830:
2826:
2822:
2818:
2814:
2810:
2806:
2802:
2798:
2794:
2790:
2786:
2782:
2778:
2774:
2770:
2766:
2762:
2758:
2754:
2750:
2746:
2742:
2738:
2734:
2730:
2726:
2722:
2718:
2714:
2710:
2706:
2702:
2698:
2694:
2690:
2686:
2682:
2678:
2674:
2670:
2669:palmitic acid
2666:
2662:
2661:linoleic acid
2658:
2654:
2650:
2646:
2642:
2638:
2637:Ellagitannins
2634:
2630:
2626:
2622:
2618:
2614:
2610:
2606:
2602:
2598:
2594:
2590:
2586:
2582:
2578:
2577:Ascorbic acid
2574:
2570:
2566:
2562:
2561:Abyssinone II
2558:
2554:
2550:
2546:
2542:
2538:
2535:
2533:
2529:
2525:
2521:
2517:
2513:
2509:
2505:
2501:
2497:
2493:
2489:
2486:
2482:
2476:
2473:
2472:
2469:
2465:
2461:
2457:
2453:
2449:
2446:
2444:
2440:
2436:
2432:
2428:
2425:
2423:
2419:
2415:
2411:
2407:
2403:
2400:
2396:
2387:
2382:
2381:
2378:
2376:
2372:
2368:
2364:
2360:
2356:
2352:
2348:
2344:
2340:
2336:
2332:
2328:
2324:
2320:
2316:
2315:linoleic acid
2312:
2308:
2304:
2300:
2296:
2292:
2288:
2284:
2280:
2276:
2272:
2268:
2264:
2260:
2259:Δ-Abiraterone
2256:
2253:
2251:
2247:
2243:
2239:
2235:
2231:
2227:
2223:
2219:
2215:
2211:
2207:
2203:
2199:
2195:
2191:
2187:
2183:
2179:
2175:
2171:
2167:
2164:
2160:
2154:
2151:
2150:
2147:
2145:
2141:
2137:
2133:
2129:
2125:
2121:
2117:
2114:
2112:
2108:
2104:
2100:
2096:
2092:
2089:
2085:
2076:
2071:
2070:
2067:
2065:
2061:
2057:
2053:
2049:
2045:
2041:
2037:
2033:
2029:
2025:
2021:
2017:
2013:
2009:
2005:
2002:
2000:
1996:
1993:
1989:
1984:
1979:
1978:
1975:
1973:
1969:
1965:
1961:
1957:
1953:
1949:
1945:
1941:
1937:
1933:
1929:
1925:
1921:
1917:
1913:
1909:
1905:
1904:Δ-Abiraterone
1902:
1900:
1896:
1892:
1888:
1885:
1881:
1875:
1872:
1871:
1868:
1866:
1862:
1858:
1854:
1850:
1846:
1842:
1838:
1834:
1830:
1826:
1822:
1818:
1814:
1810:
1806:
1802:
1798:
1795:
1793:
1789:
1785:
1781:
1778:
1774:
1768:
1765:
1764:
1761:
1759:
1755:
1751:
1747:
1743:
1739:
1738:Carbenoxolone
1735:
1731:
1727:
1723:
1719:
1715:
1711:
1708:
1706:
1702:
1699:
1695:
1686:
1681:
1680:
1677:
1675:
1671:
1667:
1663:
1659:
1655:
1651:
1647:
1643:
1639:
1635:
1634:Rosiglitazone
1631:
1627:
1623:
1619:
1615:
1611:
1607:
1603:
1599:
1595:
1591:
1587:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1539:
1535:
1531:
1527:
1523:
1519:
1515:
1514:Δ-Abiraterone
1511:
1507:
1504:
1502:
1498:
1494:
1490:
1486:
1482:
1478:
1474:
1471:
1467:
1462:
1457:
1456:
1453:
1451:
1447:
1443:
1442:Rosiglitazone
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1371:
1370:Δ-Abiraterone
1367:
1364:
1362:
1358:
1354:
1350:
1346:
1342:
1338:
1334:
1330:
1326:
1323:
1319:
1310:
1305:
1304:
1301:
1299:
1295:
1291:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1244:
1242:
1238:
1234:
1230:
1226:
1222:
1219:
1215:
1206:
1201:
1200:
1197:
1195:
1191:
1187:
1183:
1180:
1178:
1174:
1171:
1166:
1161:
1160:
1157:
1155:
1151:
1147:
1144:
1142:
1138:
1135:
1130:
1125:
1124:
1121:
1119:
1115:
1111:
1107:
1103:
1099:
1096:
1094:
1090:
1086:
1082:
1079:
1074:
1069:
1068:
1065:
1063:
1059:
1055:
1051:
1047:
1043:
1039:
1035:
1031:
1027:
1024:
1022:
1018:
1015:
1011:
1005:
1002:
1001:
998:
995:
993:
990:
988:
984:
981:
979:
976:
975:
969:
964:
960:
956:
952:
948:
944:
940:
936:
932:
928:
924:
920:
916:
912:
908:
905:
904:
900:
895:
894:endometriosis
891:
890:breast cancer
887:
883:
879:
875:
871:
867:
863:
860:
859:
855:
854:neurosteroids
851:
847:
843:
839:
836:
835:
831:
830:breast cancer
828:
824:
820:
816:
812:
808:
804:
801:
800:
796:
792:
788:
784:
781:(THDOC), and
780:
776:
772:
768:
764:
760:
756:
752:
748:
744:
740:
736:
733:
732:
728:
724:
720:
716:
712:
708:
704:
701:
700:
696:
691:
690:renal disease
687:
686:heart failure
683:
679:
675:
671:
667:
664:
663:
659:
655:
651:
647:
643:
639:
635:
631:
627:
623:
619:
615:
612:
611:
607:
603:
599:
596:
595:
591:
586:
582:
578:
574:
570:
566:
562:
559:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
518:
514:
510:
507:
506:
502:
498:
494:
490:
486:
482:
478:
474:
470:
467:
466:
462:
457:
453:
449:
445:
441:
434:
429:
425:
421:
417:
414:
413:
409:
405:
401:
397:
393:
389:
385:
381:
377:
374:
373:
369:
364:
360:
359:
355:
351:
347:
343:
339:
335:
331:
328:
324:
320:
316:
312:
309:
308:
304:
300:
296:
292:
288:
284:
280:
276:
272:
265:
259:
256:
255:
251:
246:
242:
239:
235:
228:
223:
221:
219:
215:
211:
207:
203:
198:
196:
192:
191:neurosteroids
188:
184:
180:
176:
172:
168:
164:
160:
156:
152:
148:
145:
141:
137:
133:
129:
125:
121:
117:
108:
104:
99:
96:
92:
89:
87:
83:
80:
77:
76:Steroidogenic
74:
72:
68:
64:
60:
56:
54:
50:
45:
42:
41:
36:
31:
19:
5300:
5226:
5193:Exopeptidase
5163:Ribonuclease
5129:Janus kinase
5014:Lipoxygenase
4990:5α-Reductase
4912:Pharmacology
4841:
4798:
4794:
4768:
4764:
4722:
4718:
4712:
4685:
4681:
4671:
4638:
4634:
4628:
4593:
4589:
4579:
4559:
4552:
4532:
4525:
4505:
4498:
4478:
4471:
4451:
4444:
4409:
4405:
4370:
4363:
4343:
4336:
4316:
4309:
4292:
4288:
4259:
4229:
4222:
4202:
4195:
4175:
4137:
4091:
4052:
4048:
4038:
4018:
4011:
3991:
3984:
3964:
3932:
3875:
3871:
3861:
3834:
3830:
3820:
3806:
3786:
3779:
3759:
3730:
3700:
3664:(1): 60–71.
3661:
3657:
3611:
3607:
3565:
3557:Zoficonazole
3553:Zinoconazole
3549:Voriconazole
3529:Tebuconazole
3513:Ravuconazole
3497:Posaconazole
3473:Neticonazole
3465:Luliconazole
3457:Lanoconazole
3453:Ketoconazole
3449:Itraconazole
3429:Hexaconazole
3417:Flutrimazole
3401:Enilconazole
3397:Embeconazole
3381:Eberconazole
3373:Diniconazole
3369:Democonazole
3357:Clotrimazole
3345:Butoconazole
3317:Alteconazole
3309:Albaconazole
3299:intermediate
3283:
3264:Ketoconazole
3254:intermediate
3238:
3223:Ravuconazole
3219:Posaconazole
3207:Bicalutamide
3186:
3129:Pregnenolone
3074:butylparaben
2937:Troglitazone
2921:Testolactone
2845:Quinolinoids
2813:Norendoxifen
2777:Leflutrozole
2773:Ketoconazole
2757:tectochrysin
2629:Difeconazole
2613:Clotrimazole
2528:Testosterone
2512:Metandienone
2480:
2394:
2323:monolinolein
2283:Bexlosteride
2279:β-Sitosterol
2275:Azelaic acid
2250:Androstenone
2238:Testosterone
2174:Progesterone
2166:Cholestenone
2158:
2153:5α-Reductase
2103:Testosterone
2083:
2056:Osilodrostat
2044:Ketoconazole
2016:Azelnidipine
1987:
1972:Osilodrostat
1936:Ketoconazole
1879:
1833:Ketoconazole
1813:Clotrimazole
1780:Progesterone
1772:
1758:Progesterone
1693:
1666:Troglitazone
1626:Pioglitazone
1614:Mifepristone
1586:Ketoconazole
1546:Clotrimazole
1481:Progesterone
1473:Pregnenolone
1465:
1450:Troglitazone
1438:Pioglitazone
1434:Oxymetholone
1414:Medrogestone
1353:Testosterone
1329:Progesterone
1325:Pregnenolone
1317:
1282:Ketoconazole
1241:Pregnenolone
1213:
1058:Rosuvastatin
1050:Pitavastatin
1030:Cerivastatin
1026:Atorvastatin
1009:
931:voriconazole
923:ketoconazole
919:itraconazole
911:clotrimazole
886:DHEA sulfate
850:DHEA sulfate
823:testolactone
787:side effects
755:testosterone
719:testosterone
682:hypertension
678:osilodrostat
638:osilodrostat
626:ketoconazole
602:progesterone
577:ketoconazole
545:progesterone
541:ketosteroids
485:pregnenolone
477:ketoconazole
448:biosynthesis
354:osteoporosis
322:
287:rosuvastatin
279:atorvastatin
241:biosynthesis
199:
175:progestogens
163:sex steroids
140:biosynthesis
119:
115:
113:
101:Legal status
95:Nonsteroidal
38:
5242:Oxytocinase
5050:Transferase
4590:Endocr. Rev
3545:Valconazole
3541:Uniconazole
3537:Tioconazole
3525:Sulconazole
3493:Penconazole
3489:Parconazole
3485:Oxiconazole
3477:Omoconazole
3445:Isoconazole
3425:Furconazole
3413:Fluconazole
3405:Etaconazole
3361:Croconazole
3353:Cisconazole
3325:Azaconazole
3313:Aliconazole
3246:Cholesterol
3232:Cholesterol
3203:Anastrozole
3194:Cholesterol
3105:Cholesterol
2965:γ-mangostin
2961:α-mangostin
2957:garcinone E
2953:garcinone D
2933:Triadimenol
2929:Triadimefon
2925:Tioconazole
2889:resveratrol
2885:Stilbenoids
2877:zearalenone
2821:Penconazole
2801:Minamestane
2769:Isoconazole
2753:sakuranetin
2741:pinocembrin
2709:biochanin A
2653:Fatty acids
2605:Chalconoids
2573:Anastrozole
2468:Venlafaxine
2456:Mirtazapine
2452:Fluvoxamine
2439:Indometacin
2367:Turosteride
2351:Lapisteride
2343:Izonsteride
2331:Finasteride
2307:Fatty acids
2303:Epristeride
2295:Dutasteride
2271:Alfatradiol
2263:Abiraterone
2222:Aldosterone
2132:Simvastatin
2052:Mespirenone
2032:Efonidipine
2028:Cilnidipine
1999:Aldosterone
1981:Aldosterone
1908:Abiraterone
1865:Tioconazole
1857:Abiraterone
1829:Isoconazole
1801:Amphenone B
1734:Amphenone B
1730:Acetoxolone
1662:Tioconazole
1638:Seviteronel
1582:Isoconazole
1550:Cyanoketone
1526:Amphenone B
1518:Abiraterone
1461:17,20-lyase
1422:Metribolone
1390:Cyanoketone
1382:Amphenone B
1374:Abiraterone
1270:Cyanoketone
1262:Amphenone B
1221:Cholesterol
1182:Azacosterol
1177:Cholesterol
1173:Desmosterol
1141:Cholesterol
1062:Simvastatin
1054:Pravastatin
1038:Fluvastatin
1034:Colestolone
955:antifungals
915:fluconazole
811:anastrozole
751:alfatradiol
747:epristeride
743:dutasteride
739:finasteride
713:(DHEA) and
650:aldosterone
618:amphenone B
585:seviteronel
521:cyanoketone
513:amphenone B
456:cholesterol
428:desmosterol
420:azacosterol
363:colestolone
350:zoledronate
346:risedronate
342:pamidronate
338:ibandronate
334:alendronate
327:nitrogenous
323:circulating
317:(IPP) into
291:simvastatin
238:Cholesterol
155:cholesterol
107:In Wikidata
4725:: 107–11.
3587:References
3481:Orconazole
3469:Miconazole
3377:Doconazole
3337:Bifonazole
3329:Azalanstat
3303:ergosterol
3291:Lanosterol
3277:Lanosterol
3258:bile acids
2990:Flavonoids
2893:Terpenoids
2853:casimiroin
2837:Prochloraz
2833:Plomestane
2817:ORG-33,201
2805:Nimorazole
2797:Miconazole
2761:Formestane
2737:naringenin
2725:hesperetin
2721:gossypetin
2681:Flavonoids
2645:Exemestane
2641:Endosulfan
2621:Coumestrol
2601:CGS-47,645
2597:CGP-45,688
2593:Bifonazole
2585:Atamestane
2504:Nandrolone
2464:Sertraline
2460:Paroxetine
2448:Fluoxetine
2427:Coumestrol
2371:Vitamin B6
2355:Oxendolone
2327:oleic acid
2128:RM-532-105
2048:Metyrapone
2020:Benidipine
1968:Trilostane
1952:Metyrapone
1944:Metomidate
1845:Miconazole
1841:Metyrapone
1805:Bifonazole
1646:Stanozolol
1630:Prochloraz
1618:Nilutamide
1610:Miconazole
1606:MDL-27,302
1602:LY-207,320
1578:Gestrinone
1574:Galeterone
1534:Bifonazole
1530:Bifluranol
1446:Trilostane
1426:Metyrapone
1410:Gestrinone
1298:Trilostane
1190:Triparanol
1154:Triparanol
1046:Mevastatin
1042:Lovastatin
992:Inhibitors
983:Substrates
963:infections
939:lanosterol
935:ergosterol
927:miconazole
815:exemestane
791:depression
765:(BPH) and
707:reversible
670:metyrapone
630:metyrapone
573:galeterone
533:trilostane
424:triparanol
283:lovastatin
245:acetyl-CoA
157:and other
144:endogenous
40:Drug class
27:Drug class
5143:Hydrolase
5107:Integrase
5022:Aromatase
4959:Substrate
4801:: 160–9.
4406:Pituitary
4289:Pharmazie
4071:2002-4436
3680:1849-8922
3385:Econazole
3215:Fadrozole
3082:Triclosan
3066:Genistein
3042:4′OH-CB79
2998:quercetin
2994:genistein
2949:Xanthones
2917:tretinoin
2909:vitamin A
2849:berberine
2825:Phenytoin
2793:MEN-11066
2789:Melatonin
2785:Liarozole
2781:Letrozole
2749:quercetin
2733:myricetin
2705:baicalein
2677:Finrozole
2673:Fenarimol
2649:Fadrozole
2633:Econazole
2581:vitamin C
2532:Estradiol
2508:Estradiol
2475:Aromatase
2435:Genistein
2363:TFM-4AS-1
2339:Gestodene
2111:Estradiol
2040:Fadrozole
2024:Canrenone
1948:Metyrapol
1928:Fadrozole
1924:Etomidate
1920:Canrenone
1849:Midazolam
1825:Genistein
1821:Econazole
1809:Canrenone
1705:Cortisone
1622:Orteronel
1598:Liarozole
1570:Flutamide
1566:Etomidate
1562:Econazole
1538:Canrenone
1406:Genistein
1278:Etomidate
1266:Canrenone
1186:Clomifene
874:irosustat
819:letrozole
727:estradiol
622:etomidate
581:orteronel
569:etomidate
539:into Δ-3-
301:-related
171:estrogens
167:androgens
91:Steroidal
5320:Category
5189:Protease
4823:24116740
4815:25843211
4777:23905452
4747:45817485
4704:26908835
4663:33659983
4655:17023038
4620:26213785
4436:27600150
3628:22217845
3570:See also
3158:SR-16157
3070:Parabens
3062:Galangin
2986:Atrazine
2945:Vorozole
2765:Imazalil
2745:rotenone
2701:apigenin
2697:acacetin
2553:5α-DHNET
2431:Daidzein
2291:Cl-4AS-1
2255:22-Oxime
2214:Cortisol
2144:STX-2624
2140:STX-2622
2136:STX-2171
1983:synthase
1956:Mitotane
1899:Cortisol
1817:Diazepam
1754:licorice
1701:Cortisol
1654:SU-10603
1510:22-Oxime
1402:Epostane
1386:Azastene
1290:Mitotane
1150:BM-15766
997:Inducers
987:Products
951:protozoa
945:of many
842:sulfates
789:such as
773:such as
674:mitotane
642:cortisol
634:mitotane
563:such as
529:mitotane
525:epostane
517:azastene
481:mitotane
384:BM-15766
332:such as
181:such as
165:such as
147:steroids
128:inhibits
53:Synonyms
5215:Trypsin
4739:6238495
4611:4591525
4427:5080363
4301:3325988
3912:6953447
3880:Bibcode
3853:3346239
3636:5876596
3284:CYP51A1
3187:CYP27A1
3170:STX1938
3154:KW-2581
3138:Danazol
3121:Estrone
3072:(e.g.,
3033:Estrone
2992:(e.g.,
2951:(e.g.,
2905:retinol
2895:(e.g.,
2887:(e.g.,
2875:(e.g.,
2847:(e.g.,
2713:chrysin
2693:7,8-DHF
2683:(e.g.,
2655:(e.g.,
2607:(e.g.,
2500:Estrone
2481:CYP19A1
2124:Fisetin
2120:Ethanol
2116:Danazol
2107:Estrone
2074:17β-HSD
1988:CYP11B2
1880:CYP11B1
1773:CYP21A2
1726:ABT-384
1684:11β-HSD
1670:VN/87-1
1650:SU-9055
1558:Danazol
1542:CFG-920
1466:CYP17A1
1398:Danazol
1274:Danazol
1214:CYP11A1
1204:P450scc
1194:WY-3457
1164:24-DHCR
1146:AY-9944
1017:HMG-CoA
878:danazol
723:estrone
394:in the
380:AY-9944
263:HMG-CoA
206:gonadal
159:sterols
132:enzymes
79:enzymes
65:Various
5269:(EC 4)
5145:(EC 3)
5052:(EC 2)
5012:1.13
4969:(EC 1)
4849:
4821:
4813:
4775:
4745:
4737:
4702:
4661:
4653:
4618:
4608:
4567:
4540:
4533:Cancer
4513:
4486:
4459:
4434:
4424:
4378:
4351:
4324:
4299:
4267:
4237:
4210:
4183:
4145:
4099:
4069:
4026:
3999:
3972:
3940:
3910:
3903:346345
3900:
3851:
3794:
3767:
3738:
3708:
3678:
3634:
3626:
3239:CYP7A1
3179:Sterol
3166:STX681
3162:STX213
2977:YM-511
2395:AKR1C4
2385:3α-HSD
2084:HSD17B
2036:FAD286
1694:HSD11B
1506:22-ABC
1308:3β-HSD
1246:22-ABC
1128:7-DHCR
978:Enzyme
929:, and
876:, and
821:, and
749:, and
688:, and
676:, and
648:, and
636:, and
579:, and
531:, and
479:, and
348:, and
289:, and
189:, and
173:, and
138:, the
126:which
5267:Lyase
5227:Mixed
5220:Renin
5198:DPP-4
5033:1.17
5027:COX-2
5020:1.14
4923:Class
4819:S2CID
4743:S2CID
4659:S2CID
4055:(1).
3632:S2CID
3058:Equol
2913:Δ-THC
2869:XHN27
2865:XHN26
2861:XHN22
2809:NKS01
2414:THDOC
2410:DHDOC
2159:SRD5A
1674:YM116
1658:TGF-β
1318:HSD3B
1010:HMGCR
947:fungi
937:from
454:from
408:toxic
269:into
243:from
5283:4.2
5275:4.1
5250:3.5
5187:3.4
5169:3.2
5151:3.1
5100:2.7
5092:2.6
5079:2.5
5073:PARP
5071:2.4
5060:COMT
5058:2.1
5004:1.5
4996:1.4
4988:1.3
4975:1.1
4847:ISBN
4811:PMID
4773:PMID
4735:PMID
4700:PMID
4651:PMID
4616:PMID
4565:ISBN
4538:ISBN
4511:ISBN
4484:ISBN
4457:ISBN
4432:PMID
4376:ISBN
4349:ISBN
4322:ISBN
4297:PMID
4265:ISBN
4235:ISBN
4208:ISBN
4181:ISBN
4143:ISBN
4097:ISBN
4067:ISSN
4024:ISBN
3997:ISBN
3970:ISBN
3938:ISBN
3908:PMID
3849:PMID
3792:ISBN
3765:ISBN
3736:ISBN
3706:ISBN
3676:ISSN
3624:PMID
3134:AHBS
3076:) •
2981:Zinc
2975:) •
2919:) •
2891:) •
2879:) •
2871:) •
2759:) •
2717:EGCG
2671:) •
2611:) •
2583:) •
2537:4-AT
2375:Zinc
2347:L-39
2329:) •
1932:FETO
1756:) •
1590:L-39
1366:4-MA
1072:FPPS
957:and
949:and
892:and
884:and
848:and
793:and
656:and
604:and
551:and
495:and
422:and
396:gene
382:and
185:and
149:and
124:drug
5203:ACE
4803:doi
4799:153
4727:doi
4723:123
4690:doi
4643:doi
4606:PMC
4598:doi
4422:PMC
4414:doi
4057:doi
3898:PMC
3888:doi
3839:doi
3835:263
3666:doi
3616:doi
3301:to
3256:to
3092:STS
3016:EST
3007:SST
2911:),
2625:DHT
2589:ATD
450:of
142:of
62:Use
5322::
5191::
4914::
4831:^
4817:.
4809:.
4797:.
4785:^
4769:63
4767:.
4755:^
4741:.
4733:.
4721:.
4698:.
4686:56
4684:.
4680:.
4657:.
4649:.
4639:84
4637:.
4614:.
4604:.
4594:36
4592:.
4588:.
4430:.
4420:.
4410:19
4408:.
4404:.
4390:^
4293:42
4291:.
4279:^
4249:^
4157:^
4111:^
4079:^
4065:.
4051:.
4047:.
3952:^
3920:^
3906:.
3896:.
3886:.
3876:79
3874:.
3870:.
3847:.
3833:.
3829:.
3750:^
3720:^
3688:^
3674:.
3660:.
3656:.
3644:^
3630:.
3622:.
3612:43
3610:.
3594:^
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