242:
219:
116:
141:
493:
248:
147:
2665:
1845:
2073:
1119:
Matsushima M, Inazawa J, Takahashi E, Suzumori K, Nakamura Y (Jan 1997). "Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase".
2066:
1378:
Husselstein T, Schaller H, Gachotte D, Benveniste P (1999). "Delta7-sterol-C5-desaturase: molecular characterization and functional expression of wild-type and mutant alleles".
2059:
1258:"Properties and kinetics of membrane-bound enzymes when both the enzyme and substrate are components of the same microsomal membrane. Studies on lathosterol 5-desaturase"
255:
154:
1778:
1349:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1812:
721:
2443:
2438:
702:
77:
1955:
2269:
2734:
2215:
2710:
2633:
2383:
1101:
2729:
1083:
2152:
1825:
1821:
2051:
1291:
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
2571:
2527:
2430:
2210:
2040:
1771:
1549:"Lathosterolosis, a novel multiple-malformation/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase"
1320:
Poisson JP, Dupuy RP, Sarda P, et al. (1993). "Evidence that liver microsomes of human neonates desaturate essential fatty acids".
929:
241:
2519:
2455:
1913:
1808:
936:
218:
1489:
Nishi S, Nishino H, Ishibashi T (2000). "cDNA cloning of the mammalian sterol C5-desaturase and the expression in yeast mutant".
1157:
2327:
2157:
1070:
1049:
2308:
1873:
1830:
1764:
140:
115:
1066:
1178:"Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes"
2643:
2350:
2298:
2231:
1908:
1045:
2035:
1868:
992:
57:
1645:"Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency"
1518:
Sugawara T, Fujimoto Y, Ishibashi T (2001). "Molecular cloning and structural analysis of human sterol C5 desaturase".
2638:
2192:
1898:
254:
153:
2703:
2030:
1918:
1878:
1791:
1986:
1972:
1928:
1855:
1840:
1804:
247:
146:
2205:
1795:
1452:"cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid"
766:
65:
1715:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
1940:
747:
2274:
1991:
2696:
2236:
1893:
129:
2408:
2289:
1903:
1835:
1603:
1017:
44:
2279:
887:
840:
1756:
2594:
2110:
2102:
1981:
1403:
1244:
89:
2480:
1592:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
912:
891:
861:
836:
1158:"Entrez Gene: SC5DL sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like"
2605:
2535:
2200:
2181:
2008:
1883:
1744:
1701:
1666:
1631:
1578:
1535:
1506:
1477:
1438:
1395:
1366:
1337:
1308:
1279:
1236:
1207:
1136:
492:
37:
2680:
1219:
Ves-Losada A, Brenner RR (1995). "Fatty acid delta 5 desaturation in rat liver cell nuclei".
2613:
2133:
2086:
1888:
1734:
1726:
1691:
1656:
1621:
1611:
1568:
1560:
1527:
1498:
1467:
1459:
1428:
1387:
1358:
1329:
1300:
1269:
1228:
1197:
1189:
1128:
334:
265:
209:
164:
1024:. Alternatively spliced transcript variants encoding the same protein have been described.
2365:
1021:
309:
85:
1607:
2475:
2394:
2173:
1787:
1472:
1451:
1739:
1714:
1626:
1591:
1573:
1548:
1531:
1502:
1362:
1274:
1257:
1202:
1177:
636:
631:
626:
621:
616:
611:
606:
601:
585:
580:
575:
570:
565:
549:
544:
539:
534:
2723:
2676:
1333:
1304:
521:
1248:
69:
2375:
1407:
327:
106:
93:
2491:
2403:
2318:
2251:
2162:
2144:
2094:
1463:
1417:"Cloning, expression, and fatty acid regulation of the human delta-5 desaturase"
1106:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1088:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1013:
1009:
410:
2261:
2082:
1391:
226:
123:
73:
1433:
1416:
2599:
2566:
2420:
2342:
1680:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
666:
470:
348:
293:
280:
192:
179:
81:
1748:
1705:
1670:
1635:
1616:
1582:
1539:
1510:
1481:
1442:
1399:
1370:
1341:
1312:
1283:
1240:
1211:
1140:
976:
971:
2558:
2501:
2416:
2128:
1661:
1644:
960:
811:
792:
2624:
2619:
2514:
2509:
2425:
2355:
2120:
2098:
1932:
1730:
1232:
778:
733:
1193:
1132:
2545:
2540:
2468:
2463:
2090:
2023:
2018:
2013:
1996:
1859:
995:
944:
688:
48:, ERG3, S5DES, SC5DL, Sterol-C5-desaturase-like, sterol-C5-desaturase
2664:
1696:
1679:
1564:
2001:
651:
647:
2672:
1960:
1950:
1945:
1002:
61:
2055:
1760:
501:
1012:
biosynthesis. The encoded protein catalyzes the conversion of
1590:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1547:
Brunetti-Pierri N, Corso G, Rossi M, et al. (2002).
317:
2684:
1713:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1643:
Krakowiak PA, Wassif CA, Kratz L, et al. (2004).
1256:
Takakuwa Y, Nishino H, Ishibe Y, Ishibashi T (1994).
482:
2573:
2529:
2521:
2457:
2432:
1846:
Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase
1450:
Leonard AE, Kelder B, Bobik EG, et al. (2000).
2587:
2556:
2499:
2489:
2392:
2373:
2364:
2340:
2317:
2288:
2259:
2249:
2224:
2190:
2171:
2143:
2118:
2109:
1971:
1927:
1854:
1803:
1020:. Mutations in this gene have been associated with
905:
880:
854:
829:
1678:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1062:
1060:
1058:
1041:
1039:
1037:
1176:Shefer S, Salen G, Batta AK, et al. (1995).
264:
163:
627:cholesterol biosynthetic process via lathosterol
612:cholesterol biosynthetic process via desmosterol
16:Protein-coding gene in the species Homo sapiens
1067:GRCm38: Ensembl release 89: ENSMUSG00000032018
637:regulation of cholesterol biosynthetic process
2704:
2067:
1772:
8:
1046:GRCh38: Ensembl release 89: ENSG00000109929
2711:
2697:
2496:
2370:
2256:
2115:
2074:
2060:
2052:
1779:
1765:
1757:
662:
517:
305:
204:
101:
1738:
1695:
1660:
1625:
1615:
1572:
1471:
1432:
1273:
1201:
2270:Farnesyl-diphosphate farnesyltransferase
1152:
1150:
581:intracellular membrane-bounded organelle
2216:Isopentenyl-diphosphate delta isomerase
1033:
2634:Steroidogenic acute regulatory protein
1415:Cho HP, Nakamura M, Clarke SD (2000).
545:delta7-sterol 5(6)-desaturase activity
18:
269:
230:
225:
168:
127:
122:
7:
2661:
2659:
1822:Enoyl-acyl carrier protein reductase
2211:Pyrophosphomevalonate decarboxylase
2129:Acetyl-Coenzyme A acetyltransferase
2041:3-oxo-5beta-steroid 4-dehydrogenase
2036:Isovaleryl coenzyme A dehydrogenase
2683:. You can help Knowledge (XXG) by
902:
877:
851:
826:
802:
783:
757:
738:
712:
693:
487:
405:
343:
322:
14:
1914:Pyrroloquinoline-quinone synthase
998:that in humans is encoded by the
2663:
491:
253:
246:
240:
217:
152:
145:
139:
114:
2384:Cholesterol side-chain cleavage
2328:24-Dehydrocholesterol reductase
2158:3-hydroxybutyrate dehydrogenase
1008:This gene encodes an enzyme of
2735:Human chromosome 11 gene stubs
2309:7-Dehydrocholesterol reductase
1874:Coproporphyrinogen III oxidase
1831:7-Dehydrocholesterol reductase
586:endoplasmic reticulum membrane
566:integral component of membrane
550:C-5 sterol desaturase activity
502:More reference expression data
471:More reference expression data
1:
2644:Reverse cholesterol transport
2232:Dimethylallyltranstransferase
1909:Tryptophan alpha,beta-oxidase
1532:10.1016/s1388-1981(01)00160-3
1503:10.1016/s0167-4781(99)00248-1
1363:10.1016/S0378-1119(97)00411-3
1275:10.1016/S0021-9258(18)46870-6
238:
137:
2730:Genes on human chromosome 11
1869:Dihydroorotate dehydrogenase
1596:Proc. Natl. Acad. Sci. U.S.A
1334:10.1016/0005-2760(93)90149-4
1305:10.1016/0378-1119(94)90802-8
622:steroid biosynthetic process
437:anterior horn of spinal cord
2639:Cholesterol total synthesis
1899:Tetrahydroberberine oxidase
607:sterol biosynthetic process
453:subcutaneous adipose tissue
383:superior vestibular nucleus
2751:
2658:
2351:Cholesterol 7α-hydroxylase
2299:Lanosterol 14α-demethylase
2031:Glutaryl-CoA dehydrogenase
1919:L-galactonolactone oxidase
1879:Protoporphyrinogen oxidase
930:Chr 11: 121.29 – 121.31 Mb
632:lipid biosynthetic process
395:retinal pigment epithelium
2304:Sterol-C5-desaturase-like
1987:Butyryl-CoA dehydrogenase
1841:2,4 Dienoyl-CoA reductase
1464:10.1042/0264-6021:3470719
1102:"Mouse PubMed Reference:"
1084:"Human PubMed Reference:"
993:Δ7-sterol 5(6)-desaturase
975:
970:
966:
959:
943:
924:
909:
884:
873:
858:
833:
822:
809:
805:
790:
786:
777:
764:
760:
745:
741:
732:
719:
715:
700:
696:
687:
672:
665:
661:
645:
602:steroid metabolic process
520:
516:
499:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
2206:Phosphomevalonate kinase
1458:. 347 Pt 3 (3): 719–24.
1434:10.1074/jbc.274.52.37335
1941:Succinate dehydrogenase
1392:10.1023/A:1006113919172
937:Chr 9: 42.16 – 42.18 Mb
540:oxidoreductase activity
2275:Squalene monooxygenase
1992:Acyl CoA dehydrogenase
1617:10.1073/pnas.242603899
1520:Biochim. Biophys. Acta
1491:Biochim. Biophys. Acta
1322:Biochim. Biophys. Acta
2356:Sterol 27-hydroxylase
2237:Geranyl pyrophosphate
1894:Dihydrouracil oxidase
1792:CH–CH oxidoreductases
571:endoplasmic reticulum
433:epithelium of stomach
130:Chromosome 11 (human)
2290:7-Dehydrocholesterol
1904:Secologanin synthase
1836:Biliverdin reductase
1121:Cytogenet Cell Genet
1018:7-dehydrocholesterol
441:white adipose tissue
232:Chromosome 9 (mouse)
2280:Lanosterol synthase
1826:Enoyl ACP reductase
1608:2002PNAS...9916899M
989:Lathosterol oxidase
391:ganglionic eminence
379:islet of Langerhans
363:right lobe of liver
2671:This article on a
2595:Steroid metabolism
2111:Mevalonate pathway
2103:steroid metabolism
1982:Fumarate reductase
1731:10.1101/gr.2596504
1662:10.1093/hmg/ddg172
1233:10.1007/BF00928937
1221:Mol. Cell. Biochem
767:ENSMUSG00000032018
595:Biological process
559:Cellular component
528:Molecular function
421:left lobe of liver
2692:
2691:
2656:
2655:
2652:
2651:
2606:Steroid sulfatase
2583:
2582:
2336:
2335:
2245:
2244:
2201:Mevalonate kinase
2182:HMG-CoA reductase
2049:
2048:
1975:: Other acceptors
1884:Bilirubin oxidase
1602:(26): 16899–903.
1553:Am. J. Hum. Genet
1194:10.1172/JCI118223
1133:10.1159/000134427
986:
985:
982:
981:
955:
954:
920:
919:
899:
898:
869:
868:
848:
847:
818:
817:
799:
798:
773:
772:
754:
753:
728:
727:
709:
708:
657:
656:
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
367:corpus epididymis
300:
299:
199:
198:
2742:
2713:
2706:
2699:
2667:
2660:
2614:sulfotransferase
2575:
2531:
2523:
2497:
2459:
2434:
2371:
2257:
2136:(regulated step)
2134:HMG-CoA synthase
2116:
2087:lipid metabolism
2076:
2069:
2062:
2053:
1889:Acyl-CoA oxidase
1781:
1774:
1767:
1758:
1752:
1742:
1709:
1699:
1674:
1664:
1639:
1629:
1619:
1586:
1576:
1543:
1514:
1485:
1475:
1446:
1436:
1411:
1374:
1345:
1316:
1287:
1277:
1268:(45): 27889–93.
1252:
1215:
1205:
1162:
1161:
1154:
1145:
1144:
1116:
1110:
1109:
1098:
1092:
1091:
1080:
1074:
1064:
1053:
1043:
968:
967:
939:
932:
915:
903:
894:
878:
874:RefSeq (protein)
864:
852:
843:
827:
803:
784:
758:
739:
713:
694:
663:
617:lipid metabolism
535:iron ion binding
518:
504:
495:
488:
473:
425:seminal vesicula
413:
411:Top expressed in
406:
371:seminal vesicula
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
94:SC5D - orthologs
47:
40:
19:
2750:
2749:
2745:
2744:
2743:
2741:
2740:
2739:
2720:
2719:
2718:
2717:
2657:
2648:
2588:Other/ungrouped
2579:
2552:
2510:17α-Hydroxylase
2485:
2481:11β-Hydroxylase
2426:17α-Hydroxylase
2395:corticosteroids
2388:
2366:Steroidogenesis
2360:
2332:
2313:
2284:
2241:
2220:
2186:
2167:
2139:
2105:
2080:
2050:
2045:
1967:
1923:
1850:
1799:
1788:Oxidoreductases
1785:
1755:
1725:(10B): 2121–7.
1712:
1677:
1655:(13): 1631–41.
1649:Hum. Mol. Genet
1642:
1589:
1546:
1517:
1488:
1449:
1427:(52): 37335–9.
1414:
1380:Plant Mol. Biol
1377:
1357:(1–2): 149–56.
1348:
1319:
1290:
1255:
1218:
1182:J. Clin. Invest
1175:
1171:
1169:Further reading
1166:
1165:
1156:
1155:
1148:
1118:
1117:
1113:
1100:
1099:
1095:
1082:
1081:
1077:
1065:
1056:
1044:
1035:
1030:
1022:lathosterolosis
977:View/Edit Mouse
972:View/Edit Human
935:
928:
925:Location (UCSC)
911:
890:
886:
860:
839:
835:
748:ENSG00000109929
641:
590:
554:
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
2748:
2746:
2738:
2737:
2732:
2722:
2721:
2716:
2715:
2708:
2701:
2693:
2690:
2689:
2668:
2654:
2653:
2650:
2649:
2647:
2646:
2641:
2636:
2630:
2629:
2628:
2627:
2622:
2610:
2609:
2608:
2591:
2589:
2585:
2584:
2581:
2580:
2578:
2577:
2569:
2563:
2561:
2554:
2553:
2551:
2550:
2549:
2548:
2543:
2533:
2525:
2517:
2512:
2506:
2504:
2494:
2487:
2486:
2484:
2483:
2478:
2476:21-Hydroxylase
2473:
2472:
2471:
2466:
2449:
2448:
2447:
2446:
2441:
2428:
2412:
2411:
2409:18-Hydroxylase
2399:
2397:
2390:
2389:
2387:
2386:
2380:
2378:
2368:
2362:
2361:
2359:
2358:
2353:
2347:
2345:
2338:
2337:
2334:
2333:
2331:
2330:
2324:
2322:
2315:
2314:
2312:
2311:
2306:
2301:
2295:
2293:
2286:
2285:
2283:
2282:
2277:
2272:
2266:
2264:
2254:
2247:
2246:
2243:
2242:
2240:
2239:
2234:
2228:
2226:
2222:
2221:
2219:
2218:
2213:
2208:
2203:
2197:
2195:
2188:
2187:
2185:
2184:
2178:
2176:
2174:Mevalonic acid
2169:
2168:
2166:
2165:
2160:
2155:
2149:
2147:
2141:
2140:
2138:
2137:
2131:
2125:
2123:
2113:
2107:
2106:
2081:
2079:
2078:
2071:
2064:
2056:
2047:
2046:
2044:
2043:
2038:
2033:
2028:
2027:
2026:
2021:
2016:
2006:
2005:
2004:
1999:
1989:
1984:
1978:
1976:
1969:
1968:
1966:
1965:
1964:
1963:
1958:
1953:
1948:
1937:
1935:
1925:
1924:
1922:
1921:
1916:
1911:
1906:
1901:
1896:
1891:
1886:
1881:
1876:
1871:
1865:
1863:
1852:
1851:
1849:
1848:
1843:
1838:
1833:
1828:
1818:
1816:
1801:
1800:
1786:
1784:
1783:
1776:
1769:
1761:
1754:
1753:
1710:
1697:10.1038/ng1285
1675:
1640:
1587:
1565:10.1086/342668
1544:
1515:
1497:(1–2): 106–8.
1486:
1447:
1412:
1386:(5): 891–906.
1375:
1346:
1317:
1299:(1–2): 171–4.
1288:
1253:
1216:
1188:(4): 1779–85.
1172:
1170:
1167:
1164:
1163:
1146:
1111:
1093:
1075:
1054:
1032:
1031:
1029:
1026:
984:
983:
980:
979:
974:
964:
963:
957:
956:
953:
952:
950:
948:
941:
940:
933:
926:
922:
921:
918:
917:
907:
906:
900:
897:
896:
882:
881:
875:
871:
870:
867:
866:
856:
855:
849:
846:
845:
831:
830:
824:
820:
819:
816:
815:
807:
806:
800:
797:
796:
788:
787:
781:
775:
774:
771:
770:
762:
761:
755:
752:
751:
743:
742:
736:
730:
729:
726:
725:
717:
716:
710:
707:
706:
698:
697:
691:
685:
684:
679:
674:
670:
669:
659:
658:
655:
654:
643:
642:
640:
639:
634:
629:
624:
619:
614:
609:
604:
598:
596:
592:
591:
589:
588:
583:
578:
573:
568:
562:
560:
556:
555:
553:
552:
547:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
375:jejunal mucosa
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2747:
2736:
2733:
2731:
2728:
2727:
2725:
2714:
2709:
2707:
2702:
2700:
2695:
2694:
2688:
2686:
2682:
2678:
2677:chromosome 11
2674:
2669:
2666:
2662:
2645:
2642:
2640:
2637:
2635:
2632:
2631:
2626:
2623:
2621:
2618:
2617:
2616:
2615:
2611:
2607:
2604:
2603:
2602:
2601:
2596:
2593:
2592:
2590:
2586:
2576:
2570:
2568:
2565:
2564:
2562:
2560:
2555:
2547:
2544:
2542:
2539:
2538:
2537:
2534:
2532:
2526:
2524:
2518:
2516:
2513:
2511:
2508:
2507:
2505:
2503:
2498:
2495:
2493:
2488:
2482:
2479:
2477:
2474:
2470:
2467:
2465:
2462:
2461:
2460:
2454:
2451:
2450:
2445:
2442:
2440:
2437:
2436:
2435:
2429:
2427:
2424:
2422:
2418:
2414:
2413:
2410:
2407:
2405:
2401:
2400:
2398:
2396:
2391:
2385:
2382:
2381:
2379:
2377:
2372:
2369:
2367:
2363:
2357:
2354:
2352:
2349:
2348:
2346:
2344:
2339:
2329:
2326:
2325:
2323:
2320:
2316:
2310:
2307:
2305:
2302:
2300:
2297:
2296:
2294:
2291:
2287:
2281:
2278:
2276:
2273:
2271:
2268:
2267:
2265:
2263:
2258:
2255:
2253:
2248:
2238:
2235:
2233:
2230:
2229:
2227:
2223:
2217:
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2198:
2196:
2194:
2189:
2183:
2180:
2179:
2177:
2175:
2170:
2164:
2161:
2159:
2156:
2154:
2153:HMG-CoA lyase
2151:
2150:
2148:
2146:
2142:
2135:
2132:
2130:
2127:
2126:
2124:
2122:
2117:
2114:
2112:
2108:
2104:
2100:
2096:
2092:
2088:
2084:
2077:
2072:
2070:
2065:
2063:
2058:
2057:
2054:
2042:
2039:
2037:
2034:
2032:
2029:
2025:
2022:
2020:
2017:
2015:
2012:
2011:
2010:
2007:
2003:
2000:
1998:
1995:
1994:
1993:
1990:
1988:
1985:
1983:
1980:
1979:
1977:
1974:
1970:
1962:
1959:
1957:
1954:
1952:
1949:
1947:
1944:
1943:
1942:
1939:
1938:
1936:
1934:
1930:
1926:
1920:
1917:
1915:
1912:
1910:
1907:
1905:
1902:
1900:
1897:
1895:
1892:
1890:
1887:
1885:
1882:
1880:
1877:
1875:
1872:
1870:
1867:
1866:
1864:
1861:
1857:
1853:
1847:
1844:
1842:
1839:
1837:
1834:
1832:
1829:
1827:
1823:
1820:
1819:
1817:
1814:
1810:
1806:
1802:
1797:
1793:
1789:
1782:
1777:
1775:
1770:
1768:
1763:
1762:
1759:
1750:
1746:
1741:
1736:
1732:
1728:
1724:
1720:
1716:
1711:
1707:
1703:
1698:
1693:
1689:
1685:
1681:
1676:
1672:
1668:
1663:
1658:
1654:
1650:
1646:
1641:
1637:
1633:
1628:
1623:
1618:
1613:
1609:
1605:
1601:
1597:
1593:
1588:
1584:
1580:
1575:
1570:
1566:
1562:
1558:
1554:
1550:
1545:
1541:
1537:
1533:
1529:
1526:(3): 277–84.
1525:
1521:
1516:
1512:
1508:
1504:
1500:
1496:
1492:
1487:
1483:
1479:
1474:
1469:
1465:
1461:
1457:
1453:
1448:
1444:
1440:
1435:
1430:
1426:
1422:
1421:J. Biol. Chem
1418:
1413:
1409:
1405:
1401:
1397:
1393:
1389:
1385:
1381:
1376:
1372:
1368:
1364:
1360:
1356:
1352:
1347:
1343:
1339:
1335:
1331:
1328:(2): 109–13.
1327:
1323:
1318:
1314:
1310:
1306:
1302:
1298:
1294:
1289:
1285:
1281:
1276:
1271:
1267:
1263:
1262:J. Biol. Chem
1259:
1254:
1250:
1246:
1242:
1238:
1234:
1230:
1227:(2): 163–70.
1226:
1222:
1217:
1213:
1209:
1204:
1199:
1195:
1191:
1187:
1183:
1179:
1174:
1173:
1168:
1159:
1153:
1151:
1147:
1142:
1138:
1134:
1130:
1126:
1122:
1115:
1112:
1107:
1103:
1097:
1094:
1089:
1085:
1079:
1076:
1072:
1068:
1063:
1061:
1059:
1055:
1051:
1047:
1042:
1040:
1038:
1034:
1027:
1025:
1023:
1019:
1015:
1011:
1006:
1004:
1001:
997:
994:
990:
978:
973:
969:
965:
962:
958:
951:
949:
946:
942:
938:
934:
931:
927:
923:
916:
914:
908:
904:
901:
895:
893:
889:
883:
879:
876:
872:
865:
863:
857:
853:
850:
844:
842:
838:
832:
828:
825:
823:RefSeq (mRNA)
821:
814:
813:
808:
804:
801:
795:
794:
789:
785:
782:
780:
776:
769:
768:
763:
759:
756:
750:
749:
744:
740:
737:
735:
731:
724:
723:
718:
714:
711:
705:
704:
699:
695:
692:
690:
686:
683:
680:
678:
675:
671:
668:
664:
660:
653:
649:
644:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
599:
597:
594:
593:
587:
584:
582:
579:
577:
574:
572:
569:
567:
564:
563:
561:
558:
557:
551:
548:
546:
543:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:9|9 A5.1
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
170:11q23.3-q24.1
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2685:expanding it
2670:
2612:
2598:
2536:5α-Reductase
2492:sex hormones
2452:
2415:
2402:
2376:pregnenolone
2303:
2009:5α-reductase
1722:
1718:
1687:
1683:
1652:
1648:
1599:
1595:
1559:(4): 952–8.
1556:
1552:
1523:
1519:
1494:
1490:
1455:
1424:
1420:
1383:
1379:
1354:
1350:
1325:
1321:
1296:
1292:
1265:
1261:
1224:
1220:
1185:
1181:
1127:(4): 252–4.
1124:
1120:
1114:
1105:
1096:
1087:
1078:
1007:
999:
988:
987:
910:
888:NP_001020127
885:
859:
841:NM_001024956
834:
810:
791:
765:
746:
720:
701:
681:
676:
333:
326:
191:121,313,410
178:121,292,681
53:External IDs
2515:17,20-Lyase
2404:aldosterone
2319:Desmosterol
2252:cholesterol
2163:Thiophorase
2145:Ketogenesis
2095:cholesterol
1690:(1): 40–5.
1014:lathosterol
1010:cholesterol
292:42,175,552
279:42,162,891
31:Identifiers
2724:Categories
2343:Bile acids
2262:lanosterol
2097:synthesis
2083:Metabolism
1719:Genome Res
1684:Nat. Genet
1456:Biochem. J
1073:, May 2017
1052:, May 2017
1028:References
337:(ortholog)
74:HomoloGene
2675:on human
2600:sulfatase
2567:Aromatase
2559:estrogens
2502:androgens
2421:cortisone
913:NP_766357
892:NP_008849
862:NM_172769
837:NM_006918
667:Orthologs
449:esophagus
82:GeneCards
2417:cortisol
2225:Geranyl-
1862:acceptor
1815:acceptor
1749:15489334
1706:14702039
1671:12812989
1636:12477932
1583:12189593
1540:11731337
1511:10786622
1482:10769175
1443:10601301
1400:10344195
1249:43739588
1069:–
1048:–
961:Wikidata
646:Sources:
576:membrane
445:calvaria
2625:SULT2A1
2620:SULT1A1
2121:HMG-CoA
2099:enzymes
2091:ketones
1933:Quinone
1604:Bibcode
1473:1221008
1408:5643392
1371:9373149
1342:8466936
1313:8125298
1284:7961720
1241:7770068
1212:7560069
1141:8976377
1071:Ensembl
1050:Ensembl
779:UniProt
734:Ensembl
673:Species
652:QuickGO
429:jejunum
312:pattern
70:1353611
38:Aliases
2024:SRD5A3
2019:SRD5A2
2014:SRD5A1
1997:ACADSB
1973:1.3.99
1860:Oxygen
1747:
1740:528928
1737:
1704:
1669:
1634:
1627:139241
1624:
1581:
1574:378549
1571:
1538:
1509:
1480:
1470:
1441:
1406:
1398:
1369:
1340:
1311:
1282:
1247:
1239:
1210:
1203:185814
1200:
1139:
996:enzyme
947:search
945:PubMed
812:O88822
793:O75845
722:235293
689:Entrez
483:BioGPS
62:602286
2679:is a
2453:both:
2193:DMAPP
2002:ACADS
1929:1.3.5
1856:1.3.3
1805:1.3.1
1404:S2CID
1245:S2CID
1016:into
991:is a
682:Mouse
677:Human
648:Amigo
457:ileum
387:vulva
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
2681:stub
2673:gene
2572:17β-
2528:17β-
2431:11β-
2321:path
2292:path
1961:SDHD
1956:SDHC
1951:SDHB
1946:SDHA
1813:NADP
1798:1.3)
1745:PMID
1702:PMID
1667:PMID
1632:PMID
1579:PMID
1536:PMID
1524:1533
1507:PMID
1495:1490
1478:PMID
1439:PMID
1396:PMID
1367:PMID
1351:Gene
1338:PMID
1326:1167
1309:PMID
1293:Gene
1280:PMID
1237:PMID
1208:PMID
1137:PMID
1003:gene
1000:SC5D
703:6309
359:pons
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
86:SC5D
78:5044
58:OMIM
45:SC5D
22:SC5D
2574:HSD
2557:To
2530:HSD
2522:HSD
2520:3β-
2500:To
2490:To
2458:HSD
2456:3β-
2433:HSD
2393:To
2374:To
2341:To
2260:To
2250:To
2191:To
2172:To
2119:To
1809:NAD
1735:PMC
1727:doi
1692:doi
1657:doi
1622:PMC
1612:doi
1569:PMC
1561:doi
1528:doi
1499:doi
1468:PMC
1460:doi
1429:doi
1425:274
1388:doi
1359:doi
1355:200
1330:doi
1301:doi
1297:138
1270:doi
1266:269
1229:doi
1225:142
1198:PMC
1190:doi
1129:doi
288:End
187:End
90:OMA
66:MGI
2726::
2597::
2089:–
2085::
1931::
1858::
1807::
1796:EC
1790::
1743:.
1733:.
1723:14
1721:.
1717:.
1700:.
1688:36
1686:.
1682:.
1665:.
1653:12
1651:.
1647:.
1630:.
1620:.
1610:.
1600:99
1598:.
1594:.
1577:.
1567:.
1557:71
1555:.
1551:.
1534:.
1522:.
1505:.
1493:.
1476:.
1466:.
1454:.
1437:.
1423:.
1419:.
1402:.
1394:.
1384:39
1382:.
1365:.
1353:.
1336:.
1324:.
1307:.
1295:.
1278:.
1264:.
1260:.
1243:.
1235:.
1223:.
1206:.
1196:.
1186:96
1184:.
1180:.
1149:^
1135:.
1125:74
1123:.
1104:.
1086:.
1057:^
1036:^
1005:.
650:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
2712:e
2705:t
2698:v
2687:.
2546:2
2541:1
2469:2
2464:1
2444:2
2439:1
2423::
2419:/
2406::
2101:/
2093:/
2075:e
2068:t
2061:v
1824:/
1811:/
1794:(
1780:e
1773:t
1766:v
1751:.
1729::
1708:.
1694::
1673:.
1659::
1638:.
1614::
1606::
1585:.
1563::
1542:.
1530::
1513:.
1501::
1484:.
1462::
1445:.
1431::
1410:.
1390::
1373:.
1361::
1344:.
1332::
1315:.
1303::
1286:.
1272::
1251:.
1231::
1214:.
1192::
1160:.
1143:.
1131::
1108:.
1090:.
212:)
109:)
92::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
