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Upper gastrointestinal bleeding

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pump inhibitors, if they have not been started earlier, are recommended in those in whom high risk signs for bleeding are found. It is also recommended that people with high risk signs are kept in hospital for at least 72 hours. Blood transfusions are not generally recommended to correct anemia, but blood transfusions are recommended if the person is not stable (cardiovascular system instability). Oral iron can be used, but this can lead to problems with compliance, tolerance, darkening stools which may mask evidence of rebleeding and tends to be slow, especially if used in conjunction with proton pump inhibitors.
530:. A positive aspirate is more helpful than a negative aspirate (If the aspirate is positive, an upper gastrointestinal bleed is likely; if the aspirate is negative, the source of a gastrointestinal bleed is probably, but not certainly, lower). A smaller study found a sensitivity of 79% and specificity of 55%, somewhat opposite results from Witting. The accuracy of the aspirate is improved by using the Gastroccult test. 537:(Hematest reagent tablets and Bili-Labstix) or guaiac (Hemoccult and Gastroccult). There is some evidence that orthotolidine-based tests more sensitive than specific, the Hemoccult test's sensitivity reduced by the acidic environment; and the Gastroccult test be the most accurate. The sensitivity, specificity, positive predictive value, and negative predictive value have been reported as follows: 788: 51: 326: 807:
before endoscopy can decrease the amount of blood in the stomach and thus improve the operators view. This erythromycin treatment may lead to a small decrease in the need for a blood transfusion, but the overall balance of how effective erythromycin is compared to potential risks is not clear. Proton
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medications are often given in the emergent setting before an endoscopy and may reduce the need for an endoscopic haemotstatic treatment. Proton pump inhibitors decrease gastric acid production. There is insufficient evidence to determine if proton pump inhibitors decrease death rates, re-bleeding
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Barkun, AN; Almadi, M; Kuipers, EJ; Laine, L; Sung, J; Tse, F; Leontiadis, GI; Abraham, NS; Calvet, X; Chan, FKL; Douketis, J; Enns, R; Gralnek, IM; Jairath, V; Jensen, D; Lau, J; Lip, GYH; Loffroy, R; Maluf-Filho, F; Meltzer, AC; Reddy, N; Saltzman, JR; Marshall, JK; Bardou, M (22 October 2019).
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Holman used simulated gastric specimens and found the Hemoccult test to have significant problems with non-specificity and false-positive results, whereas the Gastroccult test was very accurate. Holman found that by 120 seconds after the developer was applied, the Hemoccult test was positive on
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Barkun, Alan N.; Almadi, Majid; Kuipers, Ernst J.; Laine, Loren; Sung, Joseph; Tse, Frances; Leontiadis, Grigorios I.; Abraham, Neena S.; Calvet, Xavier; Chan, Francis K.L.; Douketis, James; Enns, Robert; Gralnek, Ian M.; Jairath, Vipul; Jensen, Dennis; Lau, James; Lip, Gregory Y.H.; Loffroy,
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are believed to be equivalent for peptic ulcer bleeding. In people with a confirmed peptic ulcer, proton pump inhibitors do not reduce death rates, later bleeding events, or need for surgery. They may decrease signs of bleeding at endoscopy however. In those with less severe disease and where
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bleeding score found 16% of people presenting with upper gastrointestinal bleed had Glasgow-Blatchford score of "0", considered low. Among these people there were no deaths or interventions needed and they were able to be effectively treated in an outpatient setting.
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Upper gastrointestinal bleeding affects around 50 to 150 people per 100,000 a year. It represents over 50% of cases of gastrointestinal bleeding. A 1995 UK study found an estimated mortality risk of 11% in those admitted to hospital for gastrointestinal bleeding.
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Depending on its severity, upper gastrointestinal bleeding may carry an estimated mortality risk of 11%. However, survival has improved to about 2 percent, likely as a result of improvements in medical therapy and endoscopic control of bleeding.
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Graber CJ, et al. (2007). "A Stitch in Time — A 64-year-old man with a history of coronary artery disease and peripheral vascular disease was admitted to the hospital with a several-month history of fevers, chills, and fatigue".
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events, or the need for surgical interventions. After the initial resuscitation has been completed, treatment is instigated to limit the likelihood of re-bleeds and correct any anemia that the bleeding may have caused. Those with a
242:(maroon-coloured stool) if the hemorrhage is severe. The presentation of bleeding depends on the amount and location of hemorrhage. A person with upper gastrointestinal bleeding may also present with complications of 510:
The strongest predictors of an upper gastrointestinal bleed are black stool, age <50 years, and blood urea nitrogen/creatinine ratio 30 or more. The diagnosis of upper gastrointestinal bleeding is assumed when
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Witting MD, Magder L, Heins AE, Mattu A, Granja CA, Baumgarten M; Magder; Heins; Mattu; Granja; Baumgarten (2004). "Usefulness and validity of diagnostic nasogastric aspiration in patients without hematemesis".
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The predictive values cited are based on the prevalences of upper gastrointestinal bleeding in the corresponding studies. A clinical calculator can be used to generate predictive values for other prevalences.
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Witting MD, Magder L, Heins AE, Mattu A, Granja CA, Baumgarten M; Magder; Heins; Mattu; Granja; Baumgarten (2006). "ED predictors of upper gastrointestinal tract bleeding in patients without hematemesis".
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Sierra J, Kalangos A, Faidutti B, Christenson JT; Kalangos; Faidutti; Christenson (2003). "Aorto-enteric fistula is a serious complication to aortic surgery. Modern trends in diagnosis and therapy".
461:. Fistulae are usually secondary to prior vascular surgery and usually occur at the proximal anastomosis at the third or fourth portion of the duodenum where it is retroperitoneal and near the aorta. 1422:
Stanley AJ, Ashley D, Dalton HR, et al. (January 2009). "Outpatient management of patients with low-risk upper-gastrointestinal haemorrhage: multicentre validation and prospective evaluation".
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beginning with airway management and fluid resuscitation using either intravenous fluids and or blood. A number of medications may improve outcomes depending on the source of the bleeding.
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can help determine the location (source) of bleeding and help understand the best initial diagnostic and treatment plan. Nasogastric aspirate has a sensitivity of 42%, specificity 91%,
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Determining whether blood is in gastric contents, either vomited or aspirated specimens, may be a challenge when determining the source of the hemorrhage. Slide tests are based on
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Cai, Jennifer X.; Saltzman, John R. (July 2018). "Initial Assessment, Risk Stratification, and Early Management of Acute Nonvariceal Upper Gastrointestinal Hemorrhage".
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There are many causes for upper gastrointestinal hemorrhage. Causes are usually anatomically divided into their location in the upper gastrointestinal tract.
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Villanueva, CĂ ndid; Colomo, Alan; Bosch, Alba; ConcepciĂłn, Mar; Hernandez-Gea, Virginia; Aracil, Carles; Graupera, Isabel; Poca, MarĂ­a; et al. (2013).
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Ernst AA, Haynes ML, Nick TG, Weiss SJ; Haynes; Nick; Weiss (1999). "Usefulness of the blood urea nitrogen/creatinine ratio in gastrointestinal bleeding".
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Holman JS, Shwed JA; Shwed (1992). "Influence of sucralfate on the detection of occult blood in simulated gastric fluid by two screening tests".
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64%, positive predictive value 92% and overall accuracy of 66% in differentiating upper gastrointestinal bleeding from bleeding distal to the
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Romaric; Maluf-Filho, Fauze; Meltzer, Andrew C.; Reddy, Nageshwar; Saltzman, John R.; Marshall, John K.; Bardou, Marc (22 October 2019).
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Cendan JC, Thomas JB, Seeger JM; Thomas Jb; Seeger (2004). "Twenty-one cases of aortoenteric fistula: lessons for the general surgeon".
477: 837:. In the absence of hematemesis, 40% to 50% of people in the emergency department with gastrointestinal bleeding have an upper source. 2789: 2196: 3461: 3308: 1311:
Cuellar RE, Gavaler JS, Alexander JA, et al. (1990). "Gastrointestinal tract hemorrhage. The value of a nasogastric aspirate".
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greater than 7 to 8 g/dL and only moderate bleeding. If the INR is greater than 1.5 to 1.8 correction with fresh frozen plasma,
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AdĂŁo, Diego; Gois, Aecio FT; Pacheco, Rafael L; Pimentel, Carolina FMG; Riera, Rachel (2023-02-01). Cochrane Gut Group (ed.).
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or non-variceal sources of upper gastrointestinal hemorrhage, as the two have different treatment algorithms and prognosis.
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Kanno, Takeshi; Yuan, Yuhong; Tse, Frances; Howden, Colin W.; Moayyedi, Paul; Leontiadis, Grigorios I. (2022-01-07).
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Jairath, V; Barkun, AN (October 2011). "The overall approach to the management of upper gastrointestinal bleeding".
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Upper endoscopy within 24 hours is the recommended treatment. The benefits versus risks of placing a
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while recommended for variceal bleeding have not been found to be of general use for non-variceal bleeds.
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might be effective to reduce mortality, but the evidence for this is weak. But the evidence is promising.
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Rosenthal P, Thompson J, Singh M; Thompson; Singh (1984). "Detection of occult blood in gastric juice".
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may be used for the prevention of re-bleeding. If bleeding continues then balloon tamponade with a
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with gastrointestinal bleeding have an upper source. The diagnosis is easier when the people have
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may be used in an attempt to mechanically compress the varices. This may then be followed by a
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Bennett, Cathy; Klingenberg, Sarah Louise; Langholz, Ebbe; Gluud, Lise Lotte (2014-11-21).
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Iron is increasingly used in these cases to improve patient outcomes and void blood usage.
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for variceal bleeding) may be used. Recurrent or refractory bleeding may lead to need for
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Cat, TB; Liu-DeRyke, X (September 2010). "Medical management of variceal hemorrhage".
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is recommended within 24 hours and bleeding can be stopped by various techniques.
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endoscopy is rapidly available, they are of less immediate clinical importance.
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with a clean base, which is a common cause of upper gastrointestinal hemorrhage.
17: 2141: 1982: 1527: 1216: 1153: 994: 771:. Some evidence supports holding off on blood transfusions in those who have a 280:, in order to determine the severity of bleeding and the timing of intervention 3232: 2905: 2883: 2528: 2467: 2104: 1922:"Erythromycin prior to endoscopy for acute upper gastrointestinal haemorrhage" 809: 772: 712: 696: 490: 247: 176: 172: 168: 2065: 1734: 1581: 3182: 3152: 3015: 2993: 2846: 2697: 2671: 2533: 2523: 2410: 2371: 2304: 2171: 760: 421: 374: 298: 270: 195: 121: 2034: 1990: 1955: 1903: 1859: 1793: 1752: 1695: 1651: 1599: 1535: 1443: 1224: 1161: 1112: 1077: 1012: 960: 914: 1894: 1877: 1408: 1367: 1332: 1276: 1069: 787: 2816: 2794: 2506: 736: 443: 129: 2087: 1768:"Systematic review: tranexamic acid for upper gastrointestinal bleeding" 977:
British Society of Gastroenterology Endoscopy Committee (October 2002).
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The causes for upper gastrointestinal hemorrhage include the following:
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is preferred in people with cirrhosis. Medications typically includes
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in those with upper gastrointestinal bleeding are not well known.
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A number of medications increase the risk of bleeding including
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in order to determine if the bleeding is from a variceal source.
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examination, in order to determine possible causes of hemorrhage
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Persons with upper gastrointestinal bleeding often present with
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If large amounts of pack red blood cells are used additional
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to reduce portal pressures. This is typically in addition to
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Hemoglobin level >12.9 g/dL (men) or >11.9 g/dL (women)
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Significant upper gastrointestinal bleeding is considered a
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Based on evidence from people with other health problems
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Score is equal to "0" if the following are all present:
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Bleeding of the esophagus, stomach, or upper intestine
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Gluud, LL; Klingenberg, SL, Langholz, SE (May 2008).
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Determining whether blood is in the gastric aspirate
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double the rate of upper gastrointestinal bleeding.
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with overlying clot. Pathology was consistent with
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Gastrointestinal Endoscopy Clinics of North America
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Gastrointestinal Endoscopy Clinics of North America
670:less than 2 may not require admission to hospital. 78: 66: 40: 35: 639:No past or present liver disease or heart failure 363:People are usually stratified into having either 147:Upper gastrointestinal bleeding can be caused by 120:, commonly defined as bleeding arising from the 44:Upper gastrointestinal hemorrhage, gastrorrhagia 1871: 1869: 1509: 1507: 1505: 1503: 1501: 1840:Critical Care Nursing Clinics of North America 1499: 1497: 1495: 1493: 1491: 1489: 1487: 1485: 1483: 1481: 791:The above ulcer seen after endoscopic clipping 464:Hematobilia, or bleeding from the biliary tree 2204: 749:transjugular intrahepatic portosystemic shunt 633:Blood urea nitrogen level <18.2 mg/dL 8: 2310:Esophagogastric junction outflow obstruction 2047:: CS1 maint: multiple names: authors list ( 1814:: CS1 maint: multiple names: authors list ( 1380:: CS1 maint: multiple names: authors list ( 1289:: CS1 maint: multiple names: authors list ( 1237:: CS1 maint: multiple names: authors list ( 1182:: CS1 maint: multiple names: authors list ( 1125:: CS1 maint: multiple names: authors list ( 731:for the varices. If this is sufficient then 1715:The Cochrane Database of Systematic Reviews 1668:Serpico, M; Riscinti, M (6 December 2019). 1562:The Cochrane Database of Systematic Reviews 1250: 1248: 3330: 2981: 2497: 2349:Esophageal intramural pseudodiverticulosis 2233: 2211: 2197: 2189: 2078: 1772:Alimentary Pharmacology & Therapeutics 1663: 1661: 1306: 1304: 1302: 1300: 707:For initial fluid replacement colloids or 627:Systolic blood pressure >109 mm Hg 49: 32: 1945: 1893: 1783: 1742: 1685: 1641: 1631: 1589: 1197: 1195: 1193: 1002: 950: 928: 926: 924: 904: 894: 1833: 1831: 1829: 1827: 1825: 1093:Cardiovascular Surgery (London, England) 539: 206:may also be useful. Procedures (such as 1926:Cochrane Database of Systematic Reviews 868: 99:(maroon-coloured stool) in severe cases 2040: 1807: 1373: 1282: 1230: 1175: 1118: 829:About 75% of people presenting to the 273:concentrates on the following things: 2577:Small intestinal bacterial overgrowth 1915: 1913: 1551: 1549: 1547: 1545: 58:Endoscopic image of a posterior wall 7: 933:Beyda, R; Johari, D (22 July 2019). 1466:"Glasgow-Blatchford bleeding score" 478:superior mesenteric artery syndrome 767:should be administered to prevent 25: 3462:Spontaneous bacterial peritonitis 3309:Exocrine pancreatic insufficiency 2027:10.1016/j.annemergmed.2003.09.002 515:(vomiting of blood) is observed. 299:stigmata of chronic liver disease 3504:Gastrointestinal tract disorders 3207:Secondary sclerosing cholangitis 1785:10.1111/j.1365-2036.2008.03638.x 1360:10.1097/00004836-198404000-00004 2448:Gastric antral vascular ectasia 2443:Portal hypertensive gastropathy 2320:Gastroesophageal reflux disease 1882:New England Journal of Medicine 847:Lower gastrointestinal bleeding 432:Gastric antral vascular ectasia 106:Upper gastrointestinal bleeding 36:Upper gastrointestinal bleeding 3202:Primary sclerosing cholangitis 3052:Hepatic veno-occlusive disease 2874:Solitary rectal ulcer syndrome 1938:10.1002/14651858.CD013176.pub2 1727:10.1002/14651858.CD006640.pub3 1574:10.1002/14651858.CD005415.pub4 1: 3259:Sphincter of Oddi dysfunction 1436:10.1016/S0140-6736(08)61769-9 1313:Archives of Internal Medicine 1269:10.1016/S0735-6757(99)90021-9 1105:10.1016/S0967-2109(03)00004-8 803:to empty the stomach such as 3168:Postcholecystectomy syndrome 2687:Intestinal pseudoobstruction 2295:Esophageal motility disorder 1148:(7): 583–7, discussion 587. 610:A scoring system called the 305:Laboratory findings include 118:upper gastrointestinal tract 1852:10.1016/j.ccell.2010.02.004 1674:Academic Emergency Medicine 1620:Annals of Internal Medicine 1325:10.1001/archinte.150.7.1381 939:Academic Emergency Medicine 883:Annals of Internal Medicine 159:, and rarer causes such as 132:. Blood may be observed in 3525: 3153:Gallstone / Cholelithiasis 2677:Functional colonic disease 2473:Zollinger–Ellison syndrome 1983:10.1016/j.giec.2018.02.001 1528:10.1016/j.giec.2011.07.001 1217:10.1016/j.ajem.2005.11.005 1154:10.1177/000313480407000704 995:10.1136/gut.51.suppl_4.iv1 2354:Acute esophageal necrosis 741:Sengstaken-Blakemore tube 560:Negative predictive value 555:Positive predictive value 524:negative predictive value 114:gastrointestinal bleeding 57: 48: 2453:Gastric dumping syndrome 2328:Laryngopharyngeal reflux 2315:Diffuse esophageal spasm 779:may decrease mortality. 668:Glasgow Blatchford score 657:The initial focus is on 377:causes (gastrorrhagia): 3069:Alcoholic liver disease 2602:Bile acid malabsorption 2546:Peptic (duodenal) ulcer 470:, or bleeding from the 468:Hemosuccus pancreaticus 315:BUN-to-creatinine ratio 3079:Hepatic encephalopathy 2463:Buried bumper syndrome 2394:Peptic (gastric) ulcer 2278:Mallory–Weiss syndrome 2221:human digestive system 1348:J. Clin. Gastroenterol 852:Forrest classification 792: 502: 459:aorto-enteric fistulae 342: 232:coffee ground vomiting 200:Proton pump inhibitors 136:or in altered form as 89:coffee ground vomiting 3304:Pancreatic pseudocyst 3173:Porcelain gallbladder 2285:Zenker's diverticulum 1895:10.1056/NEJMoa1211801 1070:10.1056/NEJMcps062601 790: 663:Proton pump inhibitor 584:Physician assessment 493: 455:Vascular malformation 328: 3108:Hepatorenal syndrome 3047:Budd–Chiari syndrome 3004:Autoimmune hepatitis 2829:Intestinal adhesions 2587:Short bowel syndrome 2416:Functional dyspepsia 2334:Esophageal stricture 2300:Nutcracker esophagus 1142:The American Surgeon 1031:Global Family Doctor 831:emergency department 715:or if not available 644:Bayesian calculation 636:No melena or syncope 630:Pulse <100/minute 562:(prevalence of 39%) 520:nasogastric aspirate 267:physical examination 3509:Medical emergencies 3247:Choledocholithiasis 3118:Metabolic disorders 3084:Acute liver failure 3057:Portal hypertension 3009:Alcoholic hepatitis 2852:Radiation proctitis 2771:Mesenteric ischemia 2743:Gastroenterocolitis 2572:Blind loop syndrome 2382:MĂ©nĂ©trier's disease 2290:Barrett's esophagus 777:prothrombin complex 765:fresh frozen plasma 557:(prevalence of 39%) 542: 501:with visible vessel 437:Dieulafoy's lesions 295:portal hypertension 260:shortness of breath 194:, may be required. 3422:Undefined location 3413:Grynfeltt–Lesshaft 3314:Pancreatic fistula 3297:Pancreatic abscess 3252:Biliary dyskinesia 3223:Mirizzi's syndrome 2724:Large and/or small 2404:Dieulafoy's lesion 2273:Boerhaave syndrome 2152:External resources 2071:2021-08-27 at the 1687:10.1111/acem.13899 989:(Suppl 4): iv1–6. 952:10.1111/acem.13835 793: 725:endoscopic banding 612:Glasgow-Blatchford 540: 528:ligament of Treitz 506:Diagnostic testing 503: 399:Mallory-Weiss tear 381:Esophageal varices 343: 313:, and an elevated 222:Signs and symptoms 157:esophageal varices 87:(vomiting blood), 3486: 3485: 3482: 3481: 3322: 3321: 2924: 2923: 2781:Bowel obstruction 2483: 2482: 2186: 2185: 945:(10): 1181–1182. 801:Prokinetic agents 703:Variceal bleeding 607:control samples. 600: 599: 395:Esophageal ulcers 391:Esophageal cancer 329:Gastric ulcer in 269:performed by the 192:blood transfusion 188:Fluid replacement 184:medical emergency 175:to determine the 103: 102: 30:Medical condition 16:(Redirected from 3516: 3474:Pneumoperitoneum 3331: 3241:Common bile duct 3123:Wilson's disease 3113:Peliosis hepatis 2982: 2859:Proctalgia fugax 2766:Abdominal angina 2691:Ogilvie syndrome 2640:Pseudomembranous 2498: 2458:Gastric volvulus 2423:Pyloric stenosis 2234: 2219:Diseases of the 2213: 2206: 2199: 2190: 2079: 2053: 2052: 2046: 2038: 2009: 2003: 2002: 1966: 1960: 1959: 1949: 1917: 1908: 1907: 1897: 1873: 1864: 1863: 1835: 1820: 1819: 1813: 1805: 1787: 1763: 1757: 1756: 1746: 1721:(11): CD006640. 1706: 1700: 1699: 1689: 1665: 1656: 1655: 1645: 1635: 1633:10.7326/M19-1795 1610: 1604: 1603: 1593: 1553: 1540: 1539: 1511: 1476: 1475: 1473: 1472: 1462: 1456: 1455: 1419: 1413: 1412: 1392: 1386: 1385: 1379: 1371: 1343: 1337: 1336: 1308: 1295: 1294: 1288: 1280: 1252: 1243: 1242: 1236: 1228: 1199: 1188: 1187: 1181: 1173: 1137: 1131: 1130: 1124: 1116: 1088: 1082: 1081: 1052: 1046: 1045: 1043: 1042: 1033:. Archived from 1023: 1017: 1016: 1006: 974: 965: 964: 954: 930: 919: 918: 908: 898: 896:10.7326/M19-1795 873: 797:nasogastric tube 543: 339:gastric lymphoma 202:are often used. 153:gastric erosions 73:Gastroenterology 53: 33: 21: 18:Stomach bleeding 3524: 3523: 3519: 3518: 3517: 3515: 3514: 3513: 3489: 3488: 3487: 3478: 3443: 3432:Internal hernia 3318: 3263: 3228:Biliary fistula 3186: 3177: 3163:Adenomyomatosis 3158:Cholesterolosis 3134: 3128:Hemochromatosis 2999:Viral hepatitis 2971: 2920: 2878: 2864:Rectal prolapse 2833: 2800:Fecal impaction 2790:Intussusception 2753:Crohn's disease 2719: 2702:Toxic megacolon 2614: 2612:Large intestine 2606: 2551:Curling's ulcer 2504: 2502:Small intestine 2491: 2479: 2387:Gastroenteritis 2358: 2223: 2217: 2187: 2182: 2181: 2147: 2146: 2090: 2073:Wayback Machine 2062: 2057: 2056: 2039: 2011: 2010: 2006: 1968: 1967: 1963: 1932:(2): CD013176. 1919: 1918: 1911: 1875: 1874: 1867: 1837: 1836: 1823: 1806: 1765: 1764: 1760: 1708: 1707: 1703: 1667: 1666: 1659: 1626:(11): 805–822. 1612: 1611: 1607: 1568:(1): CD005415. 1555: 1554: 1543: 1513: 1512: 1479: 1470: 1468: 1464: 1463: 1459: 1421: 1420: 1416: 1394: 1393: 1389: 1372: 1345: 1344: 1340: 1310: 1309: 1298: 1281: 1254: 1253: 1246: 1229: 1201: 1200: 1191: 1174: 1139: 1138: 1134: 1117: 1090: 1089: 1085: 1064:(10): 1029–34. 1054: 1053: 1049: 1040: 1038: 1025: 1024: 1020: 976: 975: 968: 932: 931: 922: 889:(11): 805–822. 875: 874: 870: 865: 843: 827: 818: 785: 757: 705: 689:Tranexamic acid 676: 655: 646: 561: 556: 508: 497:image of small 488: 472:pancreatic duct 427:Gastric varices 323: 293:Assessment for 224: 204:Tranexamic acid 31: 28: 23: 22: 15: 12: 11: 5: 3522: 3520: 3512: 3511: 3506: 3501: 3491: 3490: 3484: 3483: 3480: 3479: 3477: 3476: 3471: 3469:Hemoperitoneum 3466: 3465: 3464: 3453: 3451: 3445: 3444: 3442: 3441: 3440: 3439: 3434: 3429: 3418: 3417: 3416: 3415: 3410: 3397: 3396: 3391: 3386: 3381: 3376: 3375: 3374: 3369: 3358: 3357: 3352: 3351: 3350: 3339: 3337: 3328: 3324: 3323: 3320: 3319: 3317: 3316: 3311: 3306: 3301: 3300: 3299: 3294: 3289: 3284: 3273: 3271: 3265: 3264: 3262: 3261: 3256: 3255: 3254: 3249: 3236: 3235: 3230: 3225: 3216: 3215: 3214: 3209: 3204: 3193: 3191: 3179: 3178: 3176: 3175: 3170: 3165: 3160: 3155: 3150: 3144: 3142: 3136: 3135: 3133: 3132: 3131: 3130: 3125: 3115: 3110: 3105: 3104: 3103: 3098: 3088: 3087: 3086: 3081: 3071: 3066: 3065: 3064: 3059: 3054: 3049: 3037: 3036: 3035: 3025: 3024: 3023: 3013: 3012: 3011: 3006: 3001: 2990: 2988: 2979: 2973: 2972: 2970: 2969: 2968: 2967: 2957: 2956: 2955: 2950: 2940: 2938:Blood in stool 2934: 2932: 2926: 2925: 2922: 2921: 2919: 2918: 2913: 2911:Anal dysplasia 2908: 2903: 2898: 2888: 2886: 2880: 2879: 2877: 2876: 2871: 2866: 2861: 2856: 2855: 2854: 2843: 2841: 2835: 2834: 2832: 2831: 2826: 2825: 2824: 2814: 2813: 2812: 2802: 2797: 2792: 2787: 2778: 2776:Angiodysplasia 2773: 2768: 2757: 2756: 2755: 2745: 2740: 2739: 2738: 2727: 2725: 2721: 2720: 2718: 2717: 2711:Diverticulosis 2707:Diverticulitis 2704: 2695: 2694: 2693: 2684: 2674: 2669: 2668: 2667: 2662: 2657: 2652: 2647: 2642: 2632: 2626: 2624: 2608: 2607: 2605: 2604: 2599: 2597:Milroy disease 2594: 2589: 2584: 2579: 2574: 2569: 2567:Tropical sprue 2564: 2555: 2554: 2553: 2543: 2542: 2541: 2536: 2531: 2520: 2518: 2495: 2489:Lower GI tract 2485: 2484: 2481: 2480: 2478: 2477: 2476: 2475: 2465: 2460: 2455: 2450: 2445: 2440: 2435: 2430: 2425: 2420: 2419: 2418: 2408: 2407: 2406: 2401: 2391: 2390: 2389: 2384: 2379: 2368: 2366: 2360: 2359: 2357: 2356: 2351: 2346: 2341: 2336: 2331: 2325: 2324: 2323: 2317: 2312: 2307: 2302: 2292: 2287: 2282: 2281: 2280: 2275: 2265: 2264: 2263: 2258: 2253: 2242: 2240: 2231: 2229:Upper GI tract 2225: 2224: 2218: 2216: 2215: 2208: 2201: 2193: 2184: 2183: 2180: 2179: 2168: 2156: 2155: 2153: 2149: 2148: 2145: 2144: 2133: 2122: 2107: 2091: 2086: 2085: 2083: 2082:Classification 2076: 2075: 2061: 2060:External links 2058: 2055: 2054: 2004: 1977:(3): 261–275. 1961: 1909: 1865: 1821: 1758: 1701: 1680:(4): 336–338. 1657: 1605: 1541: 1477: 1457: 1430:(9657): 42–7. 1414: 1387: 1338: 1296: 1257:Am J Emerg Med 1244: 1205:Am J Emerg Med 1189: 1132: 1083: 1047: 1018: 966: 920: 867: 866: 864: 861: 860: 859: 854: 849: 842: 839: 826: 823: 817: 814: 784: 781: 769:coagulopathies 756: 755:Blood products 753: 745:Minnesota tube 704: 701: 675: 672: 654: 651: 645: 642: 641: 640: 637: 634: 631: 628: 625: 598: 597: 594: 591: 588: 585: 581: 580: 577: 574: 571: 568: 564: 563: 558: 553: 550: 547: 507: 504: 487: 484: 483: 482: 481: 480: 474: 465: 462: 452: 450:Duodenal ulcer 441: 440: 439: 434: 429: 424: 419: 417:Gastric cancer 414: 403: 402: 401: 396: 393: 388: 383: 322: 319: 303: 302: 291: 281: 223: 220: 165:blood pressure 161:gastric cancer 101: 100: 82: 76: 75: 70: 64: 63: 60:duodenal ulcer 55: 54: 46: 45: 42: 38: 37: 29: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 3521: 3510: 3507: 3505: 3502: 3500: 3497: 3496: 3494: 3475: 3472: 3470: 3467: 3463: 3460: 3459: 3458: 3455: 3454: 3452: 3450: 3446: 3438: 3435: 3433: 3430: 3428: 3425: 3424: 3423: 3420: 3419: 3414: 3411: 3409: 3406: 3405: 3404: 3403: 3399: 3398: 3395: 3392: 3390: 3387: 3385: 3382: 3380: 3377: 3373: 3370: 3368: 3365: 3364: 3363: 3360: 3359: 3356: 3353: 3349: 3346: 3345: 3344: 3343:Diaphragmatic 3341: 3340: 3338: 3336: 3332: 3329: 3325: 3315: 3312: 3310: 3307: 3305: 3302: 3298: 3295: 3293: 3290: 3288: 3285: 3283: 3280: 3279: 3278: 3275: 3274: 3272: 3270: 3266: 3260: 3257: 3253: 3250: 3248: 3245: 3244: 3243: 3242: 3238: 3237: 3234: 3231: 3229: 3226: 3224: 3220: 3217: 3213: 3210: 3208: 3205: 3203: 3200: 3199: 3198: 3195: 3194: 3192: 3190: 3184: 3180: 3174: 3171: 3169: 3166: 3164: 3161: 3159: 3156: 3154: 3151: 3149: 3148:Cholecystitis 3146: 3145: 3143: 3141: 3137: 3129: 3126: 3124: 3121: 3120: 3119: 3116: 3114: 3111: 3109: 3106: 3102: 3099: 3097: 3094: 3093: 3092: 3091:Liver abscess 3089: 3085: 3082: 3080: 3077: 3076: 3075: 3074:Liver failure 3072: 3070: 3067: 3063: 3060: 3058: 3055: 3053: 3050: 3048: 3045: 3044: 3043: 3042: 3038: 3034: 3031: 3030: 3029: 3026: 3022: 3019: 3018: 3017: 3014: 3010: 3007: 3005: 3002: 3000: 2997: 2996: 2995: 2992: 2991: 2989: 2987: 2983: 2980: 2978: 2974: 2966: 2963: 2962: 2961: 2958: 2954: 2951: 2949: 2946: 2945: 2944: 2941: 2939: 2936: 2935: 2933: 2931: 2927: 2917: 2914: 2912: 2909: 2907: 2904: 2902: 2899: 2897: 2893: 2890: 2889: 2887: 2885: 2881: 2875: 2872: 2870: 2867: 2865: 2862: 2860: 2857: 2853: 2850: 2849: 2848: 2845: 2844: 2842: 2840: 2836: 2830: 2827: 2823: 2820: 2819: 2818: 2815: 2811: 2808: 2807: 2806: 2803: 2801: 2798: 2796: 2793: 2791: 2788: 2786: 2782: 2779: 2777: 2774: 2772: 2769: 2767: 2763: 2762: 2758: 2754: 2751: 2750: 2749: 2746: 2744: 2741: 2737: 2734: 2733: 2732: 2731:Enterocolitis 2729: 2728: 2726: 2722: 2716: 2712: 2708: 2705: 2703: 2699: 2696: 2692: 2688: 2685: 2683: 2680: 2679: 2678: 2675: 2673: 2670: 2666: 2663: 2661: 2658: 2656: 2653: 2651: 2648: 2646: 2643: 2641: 2638: 2637: 2636: 2633: 2631: 2628: 2627: 2625: 2622: 2618: 2613: 2609: 2603: 2600: 2598: 2595: 2593: 2590: 2588: 2585: 2583: 2580: 2578: 2575: 2573: 2570: 2568: 2565: 2563: 2559: 2558:Malabsorption 2556: 2552: 2549: 2548: 2547: 2544: 2540: 2537: 2535: 2532: 2530: 2527: 2526: 2525: 2522: 2521: 2519: 2516: 2512: 2508: 2503: 2499: 2496: 2494: 2490: 2486: 2474: 2471: 2470: 2469: 2466: 2464: 2461: 2459: 2456: 2454: 2451: 2449: 2446: 2444: 2441: 2439: 2436: 2434: 2433:Gastroparesis 2431: 2429: 2426: 2424: 2421: 2417: 2414: 2413: 2412: 2409: 2405: 2402: 2400: 2399:Cushing ulcer 2397: 2396: 2395: 2392: 2388: 2385: 2383: 2380: 2378: 2375: 2374: 2373: 2370: 2369: 2367: 2365: 2361: 2355: 2352: 2350: 2347: 2345: 2344:Megaesophagus 2342: 2340: 2337: 2335: 2332: 2329: 2326: 2321: 2318: 2316: 2313: 2311: 2308: 2306: 2303: 2301: 2298: 2297: 2296: 2293: 2291: 2288: 2286: 2283: 2279: 2276: 2274: 2271: 2270: 2269: 2266: 2262: 2259: 2257: 2254: 2252: 2249: 2248: 2247: 2244: 2243: 2241: 2239: 2235: 2232: 2230: 2226: 2222: 2214: 2209: 2207: 2202: 2200: 2195: 2194: 2191: 2178: 2174: 2173: 2169: 2167: 2163: 2162: 2158: 2157: 2154: 2150: 2143: 2139: 2138: 2134: 2132: 2128: 2127: 2123: 2121: 2117: 2116: 2112: 2108: 2106: 2102: 2101: 2097: 2093: 2092: 2089: 2084: 2080: 2074: 2070: 2067: 2064: 2063: 2059: 2050: 2044: 2036: 2032: 2028: 2024: 2021:(4): 525–32. 2020: 2016: 2015:Ann Emerg Med 2008: 2005: 2000: 1996: 1992: 1988: 1984: 1980: 1976: 1972: 1965: 1962: 1957: 1953: 1948: 1943: 1939: 1935: 1931: 1927: 1923: 1916: 1914: 1910: 1905: 1901: 1896: 1891: 1887: 1883: 1879: 1872: 1870: 1866: 1861: 1857: 1853: 1849: 1846:(3): 381–93. 1845: 1841: 1834: 1832: 1830: 1828: 1826: 1822: 1817: 1811: 1803: 1799: 1795: 1791: 1786: 1781: 1777: 1773: 1769: 1762: 1759: 1754: 1750: 1745: 1740: 1736: 1732: 1728: 1724: 1720: 1716: 1712: 1705: 1702: 1697: 1693: 1688: 1683: 1679: 1675: 1671: 1664: 1662: 1658: 1653: 1649: 1644: 1639: 1634: 1629: 1625: 1621: 1617: 1609: 1606: 1601: 1597: 1592: 1587: 1583: 1579: 1575: 1571: 1567: 1563: 1559: 1552: 1550: 1548: 1546: 1542: 1537: 1533: 1529: 1525: 1522:(4): 657–70. 1521: 1517: 1510: 1508: 1506: 1504: 1502: 1500: 1498: 1496: 1494: 1492: 1490: 1488: 1486: 1484: 1482: 1478: 1467: 1461: 1458: 1453: 1449: 1445: 1441: 1437: 1433: 1429: 1425: 1418: 1415: 1410: 1406: 1402: 1398: 1391: 1388: 1383: 1377: 1369: 1365: 1361: 1357: 1354:(2): 119–21. 1353: 1349: 1342: 1339: 1334: 1330: 1326: 1322: 1319:(7): 1381–4. 1318: 1314: 1307: 1305: 1303: 1301: 1297: 1292: 1286: 1278: 1274: 1270: 1266: 1262: 1258: 1251: 1249: 1245: 1240: 1234: 1226: 1222: 1218: 1214: 1210: 1206: 1198: 1196: 1194: 1190: 1185: 1179: 1171: 1167: 1163: 1159: 1155: 1151: 1147: 1143: 1136: 1133: 1128: 1122: 1114: 1110: 1106: 1102: 1098: 1094: 1087: 1084: 1079: 1075: 1071: 1067: 1063: 1059: 1051: 1048: 1037:on 2011-07-11 1036: 1032: 1028: 1022: 1019: 1014: 1010: 1005: 1000: 996: 992: 988: 984: 980: 973: 971: 967: 962: 958: 953: 948: 944: 940: 936: 929: 927: 925: 921: 916: 912: 907: 902: 897: 892: 888: 884: 880: 872: 869: 862: 858: 857:Rockall score 855: 853: 850: 848: 845: 844: 840: 838: 836: 832: 824: 822: 815: 813: 811: 806: 802: 798: 789: 782: 780: 778: 774: 770: 766: 762: 754: 752: 750: 746: 742: 738: 734: 733:beta blockers 730: 729:sclerotherapy 726: 722: 721:nitroglycerin 718: 714: 710: 702: 700: 698: 694: 690: 685: 681: 674:Peptic ulcers 673: 671: 669: 664: 660: 659:resuscitation 652: 650: 643: 638: 635: 632: 629: 626: 623: 622: 621: 620: 616: 613: 608: 606: 595: 592: 589: 586: 583: 582: 578: 575: 572: 569: 566: 565: 559: 554: 551: 548: 545: 544: 538: 536: 535:orthotolidine 531: 529: 525: 521: 516: 514: 505: 500: 499:gastric ulcer 496: 492: 485: 479: 475: 473: 469: 466: 463: 460: 456: 453: 451: 448: 447: 445: 442: 438: 435: 433: 430: 428: 425: 423: 420: 418: 415: 413: 412:Gastric ulcer 410: 409: 407: 404: 400: 397: 394: 392: 389: 387: 384: 382: 379: 378: 376: 373: 372: 371: 368: 366: 361: 358: 356: 352: 348: 340: 336: 332: 327: 320: 318: 316: 312: 308: 300: 296: 292: 289: 285: 282: 279: 276: 275: 274: 272: 268: 263: 261: 257: 253: 249: 245: 241: 237: 233: 229: 221: 219: 215: 213: 209: 205: 201: 197: 193: 190:, as well as 189: 185: 180: 178: 174: 171:, as well as 170: 166: 162: 158: 154: 150: 149:peptic ulcers 145: 143: 139: 135: 131: 127: 123: 119: 115: 111: 107: 98: 94: 90: 86: 83: 81: 77: 74: 71: 69: 65: 61: 56: 52: 47: 43: 39: 34: 19: 3421: 3400: 3277:Pancreatitis 3239: 3189:biliary tree 3062:Nutmeg liver 3039: 2965:Hematochezia 2942: 2916:Pruritus ani 2901:Anal abscess 2896:Anal fistula 2892:Anal fissure 2805:Constipation 2759: 2630:Appendicitis 2438:Gastroptosis 2428:Achlorhydria 2267: 2256:Eosinophilic 2170: 2159: 2135: 2124: 2109: 2094: 2043:cite journal 2018: 2014: 2007: 1974: 1970: 1964: 1929: 1925: 1888:(1): 11–21. 1885: 1881: 1843: 1839: 1810:cite journal 1778:(9): 752–8. 1775: 1771: 1761: 1718: 1714: 1704: 1677: 1673: 1623: 1619: 1608: 1565: 1561: 1519: 1515: 1469:. Retrieved 1460: 1427: 1423: 1417: 1403:(7): 625–7. 1400: 1396: 1390: 1376:cite journal 1351: 1347: 1341: 1316: 1312: 1285:cite journal 1260: 1256: 1233:cite journal 1211:(3): 280–5. 1208: 1204: 1178:cite journal 1145: 1141: 1135: 1121:cite journal 1099:(3): 185–8. 1096: 1092: 1086: 1061: 1058:N Engl J Med 1057: 1050: 1039:. Retrieved 1035:the original 1030: 1021: 986: 982: 942: 938: 886: 882: 871: 828: 825:Epidemiology 819: 805:erythromycin 794: 758: 706: 693:Somatostatin 677: 656: 647: 618: 617: 609: 604: 601: 567:Gastroccult 532: 517: 509: 457:, including 369: 362: 359: 344: 311:coagulopathy 304: 264: 246:, including 240:hematochezia 225: 216: 181: 146: 109: 105: 104: 97:hematochezia 3457:Peritonitis 3219:Cholestasis 3197:Cholangitis 3140:Gallbladder 3028:Fatty liver 2948:Hematemesis 2930:GI bleeding 2736:Necrotizing 2665:Lymphocytic 2660:Collagenous 2655:Microscopic 2592:Steatorrhea 2493:Enteropathy 2339:Inlet patch 2261:Herpetiform 2246:Esophagitis 2161:MedlinePlus 1263:(1): 70–2. 835:hematemesis 717:vasopressin 680:crystalloid 552:Specificity 549:Sensitivity 513:hematemesis 386:Esophagitis 278:Vital signs 228:hematemesis 173:blood tests 138:black stool 85:Hematemesis 41:Other names 3493:Categories 3449:Peritoneal 3427:Incisional 3348:Congenital 3292:Hereditary 3269:Pancreatic 3233:Haemobilia 2906:Hemorrhoid 2884:Anal canal 2822:Infectious 2810:Functional 2645:Ulcerative 2529:Duodenitis 2468:Gastrinoma 2137:DiseasesDB 2066:Patient.uk 1471:2009-01-24 1397:Clin Pharm 1041:2010-11-24 863:References 810:Parenteral 783:Procedures 773:hemoglobin 713:octreotide 697:octreotide 495:Endoscopic 375:Esophageal 248:chest pain 177:hemoglobin 169:heart rate 3437:Richter's 3394:Spigelian 3389:Obturator 3379:Umbilical 3212:Ascending 3183:Bile duct 3016:Cirrhosis 2994:Hepatitis 2977:Accessory 2847:Proctitis 2698:Megacolon 2672:Dysentery 2582:Whipple's 2534:Jejunitis 2524:Enteritis 2411:Dyspepsia 2372:Gastritis 2305:Achalasia 2238:Esophagus 2172:eMedicine 1735:1469-493X 1582:1469-493X 816:Prognosis 761:platelets 653:Treatment 486:Diagnosis 422:Gastritis 284:Abdominal 271:physician 196:Endoscopy 122:esophagus 68:Specialty 3499:Bleeding 3367:Indirect 3362:Inguinal 3096:Pyogenic 3041:Vascular 2817:Diarrhea 2795:Volvulus 2761:Vascular 2700: / 2689: / 2650:Ischemic 2617:Appendix 2507:Duodenum 2377:Atrophic 2251:Candidal 2177:med/3565 2069:Archived 2035:15039700 1999:49377957 1991:29933774 1956:36723439 1904:23281973 1860:20691388 1802:24594884 1794:18248659 1753:25414987 1696:31808973 1652:31634917 1600:34995368 1536:21944416 1444:19091393 1225:16635697 1170:29517032 1162:15279179 1113:12704326 1078:17804848 1013:12208839 961:31329328 915:31634917 841:See also 737:nitrates 684:colloids 446:causes: 444:Duodenal 408:causes: 365:variceal 130:duodenum 80:Symptoms 3408:Petit's 3384:Femoral 3287:Chronic 3101:Amoebic 2869:Anismus 2635:Colitis 2562:Coeliac 2539:Ileitis 2511:Jejunum 2364:Stomach 2268:Rupture 2131:D006471 1947:9891197 1744:6599825 1643:7233308 1591:8741303 1452:1738579 1409:1617913 1368:6715849 1333:2196022 1277:9928705 1004:1867732 906:7233308 709:albumin 546:Finding 476:Severe 406:Gastric 335:stomach 256:fatigue 252:syncope 212:surgery 126:stomach 116:in the 3402:Lumbar 3372:Direct 3355:Hiatus 3335:Hernia 3187:Other 2953:Melena 2839:Rectum 2322:(GERD) 2166:003133 2033:  1997:  1989:  1954:  1944:  1902:  1858:  1800:  1792:  1751:  1741:  1733:  1694:  1650:  1640:  1598:  1588:  1580:  1534:  1450:  1442:  1424:Lancet 1407:  1366:  1331:  1275:  1223:  1168:  1160:  1111:  1076:  1011:  1001:  959:  913:  903:  347:NSAIDs 331:antrum 321:Causes 307:anemia 288:rectal 244:anemia 236:melena 93:melena 3327:Other 3282:Acute 3033:MASLD 2986:Liver 2960:Lower 2943:Upper 2785:Ileus 2621:Colon 2515:Ileum 2330:(LPR) 2142:19317 2120:578.9 2105:K92.2 1995:S2CID 1798:S2CID 1448:S2CID 1166:S2CID 355:SSRIs 351:SSRIs 238:, or 142:shock 134:vomit 128:, or 112:) is 2715:SCAD 2126:MeSH 2115:9-CM 2049:link 2031:PMID 1987:PMID 1952:PMID 1930:2023 1900:PMID 1856:PMID 1816:link 1790:PMID 1749:PMID 1731:ISSN 1719:2014 1692:PMID 1648:PMID 1596:PMID 1578:ISSN 1532:PMID 1440:PMID 1405:PMID 1382:link 1364:PMID 1329:PMID 1291:link 1273:PMID 1239:link 1221:PMID 1184:link 1158:PMID 1127:link 1109:PMID 1074:PMID 1009:PMID 957:PMID 911:PMID 763:and 735:and 719:and 695:and 682:and 596:20% 579:96% 349:and 297:and 286:and 265:The 258:and 208:TIPS 167:and 110:UGIB 3021:PBC 2748:IBD 2682:IBS 2111:ICD 2096:ICD 2023:doi 1979:doi 1942:PMC 1934:doi 1890:doi 1886:368 1848:doi 1780:doi 1739:PMC 1723:doi 1682:doi 1638:PMC 1628:doi 1624:171 1586:PMC 1570:doi 1524:doi 1432:doi 1428:373 1356:doi 1321:doi 1317:150 1265:doi 1213:doi 1150:doi 1101:doi 1066:doi 1062:357 999:PMC 991:doi 983:Gut 947:doi 901:PMC 891:doi 887:171 743:or 727:or 605:all 593:53% 590:55% 587:79% 576:77% 573:82% 570:95% 333:of 3495:: 3185:/ 2783:: 2764:: 2560:: 2175:: 2164:: 2140:: 2129:: 2118:: 2103:: 2100:10 2045:}} 2041:{{ 2029:. 2019:43 2017:. 1993:. 1985:. 1975:28 1973:. 1950:. 1940:. 1928:. 1924:. 1912:^ 1898:. 1884:. 1880:. 1868:^ 1854:. 1844:22 1842:. 1824:^ 1812:}} 1808:{{ 1796:. 1788:. 1776:27 1774:. 1770:. 1747:. 1737:. 1729:. 1717:. 1713:. 1690:. 1678:27 1676:. 1672:. 1660:^ 1646:. 1636:. 1622:. 1618:. 1594:. 1584:. 1576:. 1564:. 1560:. 1544:^ 1530:. 1520:21 1518:. 1480:^ 1446:. 1438:. 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Index

Stomach bleeding

duodenal ulcer
Specialty
Gastroenterology
Symptoms
Hematemesis
coffee ground vomiting
melena
hematochezia
gastrointestinal bleeding
upper gastrointestinal tract
esophagus
stomach
duodenum
vomit
black stool
shock
peptic ulcers
gastric erosions
esophageal varices
gastric cancer
blood pressure
heart rate
blood tests
hemoglobin
medical emergency
Fluid replacement
blood transfusion
Endoscopy

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