35:
414:
Sulfatases are found in lower and higher organisms. In higher organisms they are found in intracellular and extracellular spaces. Steroid sulfatase is distributed in a wide range of tissues throughout the body, enabling sulfated steroids synthesized in the adrenals and gonads to be desulfated
440:
354:
172:
128:
116:
419:, an acidic digestive organelle found within the cell. Lysosomal sulfatases cleave a range of sulfated carbohydrates including sulfated glycosaminoglycans and
884:
Grossman AR, de Hostos EL, Schilling J (1989). "Structure and expression of the gene encoding the periplasmic arylsulfatase of
Chlamydomonas reinhardtii".
252:
1165:
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96:
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1321:
945:
1724:
1616:
1241:
424:
1310:
1306:
1302:
1218:
1051:
423:. Genetic defects in sulfatase activity can arise through mutations in individual sulfatases and result in certain
1572:
1518:
1478:
1437:
1341:
1180:
1148:
1034:
998:
784:
von Figura K, Vingron M, Schmidt B, Meyer HE, Peters C, Rommerskirch W, Rupp K, Pohlmann R, Zuhlsdorf M (1990).
1226:
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573:
556:
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212:
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594:
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965:
390:
Sulfatases play important roles in the cycling of sulfur in the environment, in the degradation of sulfated
616:
580:
1651:
1290:
683:
603:(G6S), which hydrolyzes the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate;
479:
1586:
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522:
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677:
109:
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1398:
1393:
1317:
1253:
1039:
786:"Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B"
560:
239:
406:, sulfatases form the major catalytic machinery for the synthesis and breakage of sulfate esters.
1757:
1609:
1090:
1080:
958:
909:
827:"Hunter syndrome: isolation of an iduronate-2-sulfatase cDNA clone and analysis of patient DNA"
1558:
1503:
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1346:
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448:
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39:
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1114:
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536:
499:
415:
following distribution through the circulation system. Many sulfatases are localized in the
403:
402:, and in remodelling sulfated glycosaminoglycans in the extracellular space. Together with
159:
1736:
1550:
1466:
1461:
1456:
1369:
1364:
1124:
1002:
825:
Wilson PJ, Morris CP, Anson DS, Occhiodoro T, Bielicki J, Clements PR, Hopwood JJ (1990).
748:
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631:
532:
235:
101:
913:
439:
349:{\displaystyle {\ce {R-OSO3 + H2O}}\quad {\xrightarrow{}}\quad {\ce {R-OH + HSO4-}}}
65:
1577:
1508:
1231:
1152:
447:
The following sulfatases have been shown to be structurally related based on their
368:
205:
155:
133:
1798:
77:
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1280:
1246:
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215:
89:
84:
311:
1714:
1647:
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1138:
1046:
304:
219:
187:
531:(IDS), a lysosomal enzyme that hydrolyzes the 2-sulfate groups from
34:
1656:
1407:
1403:
764:
760:
736:
376:
1790:
1388:
1265:
1258:
1202:
1197:
752:
708:
700:
149:
60:
954:
515:(STS), a membrane bound enzyme which hydrolyzes 3-beta-hydroxy
431:
ranging from defects in physical and intellectual development.
27:
Class of enzymes which break up sulfate esters by hydrolysis
375:. Sulfate esters may be formed from various alcohols and
291:
275:
946:"Annotation of the sulfatase gene family" at mad-cow.org
1789:
This article incorporates text from the public domain
255:
494:(ASB) which hydrolyzes the sulfate ester group from
1745:
1633:
1585:
1571:
1549:
1531:
1517:
1497:
1436:
1340:
1179:
1147:
997:
186:
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148:
143:
127:
115:
95:
83:
71:
59:
51:
46:
348:
1276:Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
555:, which hydrolyzes the 6-sulfate groups of the
966:
8:
1582:
1528:
1514:
973:
959:
951:
443:Ester sulfate hydrolysis by sulfate enzyme
140:
933:at the U.S. National Library of Medicine
860:
850:
801:
339:
334:
319:
315:
305:
299:
290:
285:
274:
269:
260:
256:
254:
438:
1166:Ubiquitin carboxy-terminal hydrolase L1
776:
615:, the lysosomal enzyme that hydrolyses
579:, the lysosomal enzyme that hydrolyses
29:
1746:either deoxy- or ribo-
692:Human proteins containing this domain
7:
1327:Protein serine/threonine phosphatase
508:(ASD) and E (ASE); steryl-sulfatase
1428:Cyclic nucleotide phosphodiesterase
1422:Clostridium perfringens alpha toxin
1223:Tartrate-resistant acid phosphatase
563:and D-galactose 6-sulfate units of
379:. In the latter case the resultant
1271:Pyruvate dehydrogenase phosphatase
25:
1171:4-hydroxybenzoyl-CoA thioesterase
607:N-sulfoglucosamine sulfohydrolase
571:N-sulfoglucosamine sulfohydrolase
547:N-acetylgalactosamine-6-sulfatase
359:These may be found on a range of
33:
1489:N-acetylglucosamine-6-sulfatase
1377:Sphingomyelin phosphodiesterase
314:
298:
1298:Inositol-phosphate phosphatase
1161:Palmitoyl protein thioesterase
1:
1661:RNA-induced silencing complex
803:10.1016/S0021-9258(19)39778-9
383:-sulfates can also be termed
144:Available protein structures:
1765:Serratia marcescens nuclease
1332:Dual-specificity phosphatase
1322:Protein tyrosine phosphatase
831:Proc. Natl. Acad. Sci. U.S.A
653:, which plays a role in the
1242:Fructose 1,6-bisphosphatase
435:Three-dimensional structure
425:lysosomal storage disorders
1829:
1788:
941:Overview at rndsystems.com
1479:Galactosamine-6 sulfatase
1035:6-phosphogluconolactonase
410:Occurrence and importance
139:
32:
1227:Purple acid phosphatases
935:Medical Subject Headings
557:N-acetyl-D-galactosamine
478:enzyme which hydrolyzes
852:10.1073/pnas.87.21.8531
595:glucosamine-6-sulfatase
1813:Transmembrane proteins
1652:Microprocessor complex
1291:Beta-propeller phytase
684:Pseudomonas aeruginosa
498:4-sulfate residues of
444:
350:
312:
1587:Endodeoxyribonuclease
1484:Iduronate-2-sulfatase
1237:Glucose 6-phosphatase
1023:Butyrylcholinesterase
617:N-sulfo-D-glucosamine
581:N-sulfo-D-glucosamine
523:iduronate 2-sulfatase
496:N-acetylgalactosamine
456:cerebroside-sulfatase
442:
351:
300:
1770:Micrococcal nuclease
1605:Deoxyribonuclease IV
1600:Deoxyribonuclease II
1533:Exodeoxyribonuclease
1193:Alkaline phosphatase
1018:Acetylcholinesterase
678:Klebsiella aerogenes
253:
1625:UvrABC endonuclease
1595:Deoxyribonuclease I
1318:Protein phosphatase
1254:Protein phosphatase
1052:Bile salt-dependent
1040:PAF acetylhydrolase
843:1990PNAS...87.8531W
561:chondroitin sulfate
480:cerebroside sulfate
427:with a spectrum of
344:
310:
293:
277:
1758:Mung bean nuclease
1617:Restriction enzyme
1610:Restriction enzyme
898:10.1007/BF00331273
630:sea urchin embryo
445:
392:glycosaminoglycans
346:
330:
281:
265:
1786:
1785:
1782:
1781:
1778:
1777:
1567:
1566:
1559:Oligonucleotidase
1504:deoxyribonuclease
1472:Steroid sulfatase
1347:Phosphodiesterase
1076:Hormone-sensitive
837:(21): 8531–8535.
461:steroid sulfatase
449:sequence homology
404:sulfotransferases
333:
326:
318:
308:
296:
284:
268:
259:
202:
201:
198:
197:
193:structure summary
40:Steroid sulfatase
16:(Redirected from
1820:
1635:Endoribonuclease
1621:
1615:
1583:
1529:
1515:
1215:Acid phosphatase
1096:Monoacylglycerol
1006:ester hydrolases
975:
968:
961:
952:
918:
917:
881:
875:
874:
864:
854:
822:
816:
815:
805:
796:(6): 3374–3381.
781:
672:Escherichia coli
657:of sulfates; and
537:dermatan sulfate
517:steroid sulfates
500:dermatan sulfate
355:
353:
352:
347:
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1613:
1576:
1563:
1551:Exoribonuclease
1545:
1522:
1506:
1502:
1493:
1467:Arylsulfatase L
1462:Arylsulfatase B
1457:Arylsulfatase A
1432:
1345:
1336:
1175:
1143:
1005:
993:
979:
927:
922:
921:
886:Mol. Gen. Genet
883:
882:
878:
824:
823:
819:
783:
782:
778:
773:
694:
565:keratan sulfate
541:heparan sulfate
506:arylsulfatase C
486:arylsulfatase B
466:arylsulfatase A
437:
412:
251:
250:
218:are a class of
117:OPM superfamily
42:
28:
23:
22:
15:
12:
11:
5:
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1804:
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1136:
1130:
1129:
1128:
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1103:
1101:Diacylglycerol
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1054:
1043:
1042:
1037:
1032:
1030:Pectinesterase
1027:
1026:
1025:
1020:
1013:Cholinesterase
1009:
1007:
995:
994:
980:
978:
977:
970:
963:
955:
949:
948:
943:
938:
926:
925:External links
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892:(2): 229–239.
876:
817:
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772:
769:
693:
690:
689:
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658:
655:mineralization
641:
628:
604:
592:
568:
544:
533:iduronic acids
520:
503:
483:
463:
458:
436:
433:
411:
408:
357:
356:
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329:
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236:sulfate esters
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1473:
1470:
1468:
1465:
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1460:
1458:
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1453:
1452:
1451:arylsulfatase
1448:
1447:
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1439:
1435:
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1423:
1419:
1416:
1414:
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1379:
1378:
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1361:
1360:Phospholipase
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1333:
1330:
1328:
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1323:
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1235:
1233:
1230:
1228:
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1216:
1213:
1209:
1206:
1204:
1201:
1199:
1196:
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1178:
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1137:
1135:
1132:
1131:
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1123:
1121:
1118:
1116:
1113:
1112:
1111:
1110:Phospholipase
1108:
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1099:
1097:
1094:
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1028:
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1021:
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1016:
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996:
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987:
983:
976:
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944:
942:
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911:
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895:
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795:
791:
790:J. Biol. Chem
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661:arylsulfatase
659:
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645:arylsulfatase
642:
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632:arylsulfatase
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369:carbohydrates
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62:
58:
54:
50:
45:
41:
36:
31:
19:
1620:}}
1614:{{
1578:Endonuclease
1509:ribonuclease
1449:
1441:
1232:Nucleotidase
1153:Thioesterase
889:
885:
879:
834:
830:
820:
793:
789:
779:
695:
682:
676:
670:
643:green algae
446:
413:
389:
380:
363:, including
358:
209:
206:biochemistry
203:
1753:Nuclease S1
1524:Exonuclease
1418:Lecithinase
1247:Calcineurin
1185:Phosphatase
1091:Lipoprotein
1081:Endothelial
621:glucosamine
585:glucosamine
421:glycolipids
396:glycolipids
226:class that
129:OPM protein
47:Identifiers
1066:Pancreatic
1003:Carboxylic
931:Sulfatases
771:References
429:phenotypes
385:sulfamates
361:substrates
232:hydrolysis
210:sulfatases
156:structures
18:Sulfatases
1799:IPR000917
1643:RNase III
1501:(includes
1442:Sulfatase
1355:Autotaxin
1219:Prostatic
1071:Lysosomal
986:esterases
982:Hydrolase
476:lysosomal
474:(ASA), a
341:−
321:−
307:sulfatase
262:−
244:bisulfate
90:PDOC00117
78:IPR000917
55:Sulfatase
1807:Category
1795:InterPro
1737:RNase T1
1499:Nuclease
1134:Cutinase
914:20866325
747:;
743:;
613:3.10.1.1
601:3.1.6.14
577:3.10.1.1
529:3.1.6.13
492:3.1.6.12
417:lysosome
400:lysosome
373:proteins
365:steroids
302:→
238:into an
228:catalyze
224:esterase
173:RCSB PDB
73:InterPro
1710:RNase E
1705:RNase Z
1700:RNase A
1695:RNase P
1668:RNase H
1286:Phytase
1086:Hepatic
1061:Lingual
1057:Gastric
906:2476654
871:2122463
839:Bibcode
812:2303452
755:;
751:;
735:;
731:;
727:;
719:;
715:;
711:;
707:;
703:;
699:;
667:3.1.6.1
651:3.1.6.1
638:3.1.6.1
625:sulfate
589:sulfate
553:3.1.6.4
513:3.1.6.2
472:3.1.6.8
398:in the
240:alcohol
222:of the
220:enzymes
216:3.1.6.-
85:PROSITE
66:PF00884
1648:Drosha
1573:3.1.21
1541:RecBCD
1519:3.1.11
1139:PETase
1047:Lipase
937:(MeSH)
912:
904:
869:
859:
810:
763:;
739:;
377:amines
242:and a
188:PDBsum
162:
152:
110:SUPFAM
52:Symbol
1657:Dicer
1612:;see
1438:3.1.6
1408:PDE4B
1404:PDE4A
1342:3.1.4
1311:IMPA3
1307:IMPA2
1303:IMPA1
1181:3.1.3
1149:3.1.2
999:3.1.1
910:S2CID
862:54990
765:SULF2
761:SULF1
737:GALNS
669:from
619:into
583:into
106:SCOPe
97:SCOP2
1793:and
1791:Pfam
1575:-31:
1521:-16:
1507:and
1413:PDE5
1399:PDE3
1394:PDE2
1389:PDE1
1281:PTEN
1266:OCRL
1259:PP2A
1208:ALPP
1203:ALPL
1198:ALPI
992:3.1)
902:PMID
867:PMID
808:PMID
753:SGSH
749:PIGG
733:ARSL
729:ARSK
725:ARSJ
721:ARSI
717:ARSH
713:ARSG
709:ARSF
705:ARSD
701:ARSB
697:ARSA
681:and
623:and
587:and
539:and
394:and
371:and
230:the
181:PDBj
177:PDBe
160:ECOD
150:Pfam
134:1p49
102:1auk
61:Pfam
1730:4/5
894:doi
890:218
857:PMC
847:doi
798:doi
794:265
757:STS
745:IDS
741:GNS
559:of
535:in
332:HSO
267:OSO
234:of
204:In
168:PDB
1809::
1797::
1688:2C
1683:2B
1678:2A
1659::
1650::
1440::
1320::
1309:,
1305:,
1221:)/
1183::
1151::
1120:A2
1115:A1
1001::
990:EC
984::
908:.
900:.
888:.
865:.
855:.
845:.
835:87
833:.
829:.
806:.
792:.
788:.
767:;
759:;
723:;
675:,
664:EC
648:EC
635:EC
610:EC
598:EC
574:EC
550:EC
526:EC
510:EC
489:EC
469:EC
451::
387:.
367:,
325:OH
246::
213:EC
208:,
179:;
175:;
158:/
122:24
108:/
104:/
1725:3
1720:2
1715:1
1673:1
1511:)
1424:)
1420:(
1406:/
1382:1
1370:D
1365:C
1344::
1225:/
1217:(
1125:B
1059:/
988:(
974:e
967:t
960:v
916:.
896::
873:.
849::
841::
814:.
800::
687:.
640:;
627:;
591:;
567:;
543:;
519:;
502:;
482:;
381:N
336:4
328:+
317:R
295:O
287:2
283:H
279:+
271:3
258:R
20:)
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