1781:) that may enhance translation, in a sequence- and secondary structure- specific way. While differences at the 5’UTR are shown to regulate both transcription and translation, polymorphisms at the 3’UTR of SP-A2 variants are shown to primarily, differentially affect translation efficiency via mechanisms that involve binding of proteins and/or . The impact of this regulation on SFTPA2 relative protein levels may contribute to individual differences in susceptibility to lung disease. Environmental insults and pollutants also affect SFTPA2 expression. Exposure of lung cells to
242:
219:
1042:
116:
141:
248:
147:
1813:
3988:
Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de
Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (March 2000).
1207:
structures. The mature SP-A2 monomer is a 35kDa protein that differs from SP-A1 in four amino acids at the coding region. The structure of SP-A2 monomers consists of four domains: an N-terminal, a collagen-like domain, a neck region, and a carbohydrate recognition domain. The C-terminal carbohydrate
1212:
and molecules. The amino acid differences that distinguish between SFTPA2 and SFTPA1 genes and between their corresponding variants are located at the collagen-like domain. The amino acid differences that distinguish among SFTPA2 variants are located both at the carbohydrate recognition and the
1773:, and plays a key role in the differential regulation of SFTPA2 and SFTPA1 expression. Both ABD and ABD’ are the most represented forms among SFTPA2 transcripts (~49% each), and experimental work has shown that this sequence can stabilize mRNA, enhance translation, and activate cap-independent
2831:
Tagaram HR, Wang G, Umstead TM, Mikerov AN, Thomas NJ, Graff GR, Hess JC, Thomassen MJ, Kavuru MS, Phelps DS, Floros J (May 2007). "Characterization of a human surfactant protein A1 (SP-A1) gene-specific antibody; SP-A1 content variation among individuals of varying age and pulmonary health".
1216:
SP-A2 monomers group with other SP-A2 or SP-A1 monomers in trimeric structural subunits of 105kDa. Six of these structures group in 630 kDa structures that resemble flower bouquets. These oligomers contain a total of eighteen SP-A2 and/or SP-A1 monomers.
4182:
3601:
Voss T, Melchers K, Scheirle G, Schäfer KP (January 1991). "Structural comparison of recombinant pulmonary surfactant protein SP-A derived from two human coding sequences: implications for the chain composition of natural human SP-A".
4187:
1080:, but also for maintaining lung health, and normal lung function throughout life. Quantitative and/or qualitative alterations in surfactant composition and/or function are associated with respiratory diseases.
4129:
Madan T, Saxena S, Murthy KJ, Muralidhar K, Sarma PU (October 2002). "Association of polymorphisms in the collagen region of human SP-A1 and SP-A2 genes with pulmonary tuberculosis in Indian population".
2660:
Floros J; Wang G; Lin Z (2005). "Genetic
Diversity of Human SP-A, a Molecule with Innate host Defense and Surfactant-Related Functions; Characteristics, Primary Function, and Significance".
3798:
Kölble K, Lu J, Mole SE, Kaluz S, Reid KB (August 1993). "Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster".
1187:
among individuals. More than 30 variants have been identified and characterized for SFTPA2 (and SFTPA1) in the population. SFTPA2 variants result from nucleotide changes in the codons of
1405:
Environmental insults such as air pollution, and exposure to high concentrations of ozone and particulate matter can affect SP-A expression and function, via mechanisms that involve
3827:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1124:
and other tissues. While the majority of these tissues express both SFTPA2 and SFTPA1 transcripts, only SFTPA2 expression was found in the trachea and prostate. Using specific
3660:
White RT, Damm D, Miller J, Spratt K, Schilling J, Hawgood S, Benson B, Cordell B (1985). "Isolation and characterization of the human pulmonary surfactant apoprotein gene".
3406:
Wang G, Guo X, Floros J (September 2005). "Differences in the translation efficiency and mRNA stability mediated by 5'-UTR splice variants of human SP-A1 and SP-A2 genes".
2325:
Floros J, Wang G (May 2001). "A point of view: quantitative and qualitative imbalance in disease pathogenesis; pulmonary surfactant protein A genetic variants as a model".
1425:
with developmental insufficiency of surfactant production and structural immaturity in the lungs. Alterations of the relative levels of SP-A1 and SP-A2 have been found in
255:
154:
4042:
Wang G, Phelps DS, Umstead TM, Floros J (May 2000). "Human SP-A protein variants derived from one or both genes stimulate TNF-alpha production in the THP-1 cell line".
1195:
substitution (amino acid 140). Six SP-A2 variants (1A, 1A, 1A, 1A, 1A, 1A) are in higher frequency in the general population. The most frequently found variant is 1A.
1156:, close to SFTPA1. The SFTPA2 gene is 4556 base pairs in length, and 94% similar to SFTPA1. The structure of SFTPA2 consists of four coding exons (I-IV), and several
3631:
Haagsman HP, White RT, Schilling J, Lau K, Benson BJ, Golden J, Hawgood S, Clements JA (December 1989). "Studies of the structure of lung surfactant protein SP-A".
2412:
Madsen J, Tornoe I, Nielsen O, Koch C, Steinhilber W, Holmskov U (November 2003). "Expression and localization of lung surfactant protein A in human tissues".
3920:
Saitoh H, Okayama H, Shimura S, Fushimi T, Masuda T, Shirato K (August 1998). "Surfactant protein A2 gene expression by human airway submucosal gland cells".
3359:"Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure"
3856:
Stuart GR, Lynch NJ, Day AJ, Schwaeble WJ, Sim RB (December 1997). "The C1q and collectin binding site within C1q receptor (cell surface calreticulin)".
688:
77:
3441:
Wang G, Guo X, Floros J (May 2003). "Human SP-A 3'-UTR variants mediate differential gene expression in basal levels and in response to dexamethasone".
707:
3486:"Respiratory syncytial virus infection alters surfactant protein A expression in human pulmonary epithelial cells by reducing translation efficiency"
1765:
sequence, length, and relative amount. Most SFTPA2 specific 5’UTRs include exon B. This 30-nucleotide long sequence has been shown to enhance both
1191:
9, 91, 140, and 223. Three of these do not modify the SP-A2 protein sequence (amino acids 9, 91, and 223), whereas the remaining one results in an
3740:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
4100:
Lin Z, deMello D, Phelps DS, Koltun WA, Page M, Floros J (2002). "Both human SP-A1 and Sp-A2 genes are expressed in small and large intestine".
1452:
in several populations of neonates, children, and adults. SFTPA2 mutations also associated with pulmonary fibrosis via mechanisms that involve
1977:
4177:
3769:
McCormick SM, Boggaram V, Mendelson CR (April 1994). "Characterization of mRNA transcripts and organization of human SP-A1 and SP-A2 genes".
1995:
1418:
2878:
Wang Y, Voelker DR, Lugogo NL, Wang G, Floros J, Ingram JL, Chu HW, Church TD, Kandasamy P, Fertel D, Wright JR, Kraft M (October 2011).
241:
3027:
Lin Z, Thomas NJ, Bibikova M, Seifart C, Wang Y, Guo X, Wang G, Vollmer E, Goldmann T, Garcia EW, Zhou L, Fan JB, Floros J (July 2007).
1160:
untranslated exons (A, B, B’, C, C’, D, D’). The expression of SFTPA2 is regulated by cellular factors including proteins, small RNAs (
4071:
Berg T, Leth-Larsen R, Holmskov U, Højrup P (November 2000). "Structural characterisation of human proteinosis surfactant protein A".
927:
934:
218:
3572:
Katyal SL, Singh G, Locker J (April 1992). "Characterization of a second human pulmonary surfactant-associated protein SP-A gene".
3307:"Human SP-A1 (SFTPA1) variant-specific 3' UTRs and poly(A) tail differentially affect the in vitro translation of a reporter gene"
2929:"Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress"
2013:
1964:
1943:
1750:
140:
115:
1960:
3161:
Karinch AM, Floros J (January 1995). "5' splicing and allelic variants of the human pulmonary surfactant protein A genes".
2610:"Genetic complexity of the human innate host defense molecules, surfactant protein A1 (SP-A1) and SP-A2—impact on function"
1939:
1038:. The protein component of surfactant helps in the modulation of the innate immune response, and inflammatory processes.
57:
254:
153:
1820:
The 2013 version of this article was updated by an external expert under a dual publication model. The corresponding
1789:
of 5’UTR exons of SFTPA2 transcripts. Pollutants and viral infections also affect SFTPA2 translation mechanisms (see
3705:
Floros J, Steinbrink R, Jacobs K, Phelps D, Kriz R, Recny M, Sultzman L, Jones S, Taeusch HW, Frank HA (July 1986).
247:
146:
2503:"Novel, non-radioactive, simple and multiplex PCR-cRFLP methods for genotyping human SP-A and SP-D marker alleles"
3253:"Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution"
1298:
The role of SFTPA2 in innate immunity has been extensively studied. SP-A has the ability to bind and agglutinate
1173:
2689:"Effect of cysteine 85 on biochemical properties and biological function of human surfactant protein A variants"
3201:"The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation"
2079:
Perez-Gil J, Weaver TE (June 2010). "Pulmonary surfactant pathophysiology: current models and open questions".
1749:
of mature mRNA. One of the important features of human surfactant protein A mRNAs is that they have a variable
1259:
752:
65:
1362:
1266:
733:
1041:
3958:
2421:
1790:
1774:
1390:
1453:
1821:
1794:
1770:
1746:
1457:
1125:
129:
2195:
Phelps DS (2001). "Surfactant regulation of host defense function in the lung: a question of balance".
1460:
stress. Methylation of SFTPA2 and SFTPA1 promoter sequences has also been found in lung cancer tissue.
3707:"Isolation and characterization of cDNA clones for the 35-kDa pulmonary surfactant-associated protein"
4002:
3669:
2980:"Surfactant protein DNA methylation: a new entrant in the field of lung cancer diagnostics? (Review)"
1911:
1906:
1398:
1129:
1058:
1023:
44:
3963:
2426:
2290:
Floros J, Kala P (1998). "Surfactant proteins: molecular genetics of neonatal pulmonary diseases".
1334:
1246:
1141:
889:
885:
881:
834:
830:
826:
3949:
Goss KL, Kumar AR, Snyder JM (October 1998). "SP-A2 gene expression in human fetal lung airways".
48:, COLEC5, PSAP, PSP-A, PSPA, SFTP1, SFTPA2B, SP-A, SPA2, SPAII, surfactant protein A2, SP-2A, ILD2
4155:
3693:
3466:
2857:
2220:
2177:
1782:
1766:
1742:
1133:
1097:
1031:
89:
910:
855:
4147:
4117:
4088:
4059:
4030:
3976:
3937:
3908:
3873:
3844:
3815:
3786:
3757:
3728:
3685:
3648:
3619:
3589:
3560:
3515:
3458:
3423:
3388:
3336:
3282:
3230:
3178:
3140:
3091:
3050:
3009:
2960:
2909:
2849:
2808:
2787:"Immunogold localization of SP-A in lungs of infants dying from respiratory distress syndrome"
2767:
2718:
2639:
2583:
2534:
2480:
2439:
2391:
2342:
2307:
2272:
2212:
2169:
2134:
2096:
2061:
1877:
1859:
1833:
1386:
37:
3111:"Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A"
4139:
4109:
4080:
4051:
4020:
4010:
3968:
3929:
3898:
3865:
3836:
3807:
3778:
3749:
3718:
3677:
3640:
3611:
3581:
3550:
3505:
3497:
3450:
3415:
3378:
3370:
3326:
3318:
3272:
3264:
3220:
3212:
3170:
3130:
3122:
3081:
3040:
2999:
2991:
2950:
2940:
2899:
2891:
2841:
2798:
2757:
2749:
2708:
2700:
2669:
2629:
2621:
2573:
2565:
2524:
2514:
2470:
2431:
2381:
2373:
2334:
2299:
2262:
2254:
2204:
2161:
2126:
2088:
2051:
2043:
1885:
1867:
1851:
1786:
1754:
334:
265:
209:
164:
85:
2625:
2152:
Crouch E, Hartshorn K, Ofek I (February 2000). "Collectins and pulmonary innate immunity".
1430:
1422:
1394:
1382:
1319:
1165:
1113:
1077:
1027:
309:
2377:
4006:
3673:
2243:"Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury"
1057:. Together with (surfactant protein A1 ) SP-A1, they are the most abundant proteins of
3887:"Regulation of expression of human SP-A1 and SP-A2 genes in fetal lung explant culture"
3510:
3485:
3383:
3358:
3331:
3306:
3277:
3252:
3225:
3200:
3135:
3110:
3070:"Regulation of expression of human SP-A1 and SP-A2 genes in fetal lung explant culture"
3004:
2979:
2955:
2928:
2904:
2879:
2803:
2786:
2762:
2737:
2713:
2688:
2634:
2609:
2578:
2553:
2529:
2502:
2386:
2361:
2267:
2242:
2056:
2031:
1872:
1842:
1837:
1448:, haplotypes, and other genetic variations have been associated with acute and chronic
1282:
1209:
1121:
1066:
4084:
3903:
3886:
3869:
3840:
3723:
3706:
3555:
3538:
3086:
3069:
2475:
2458:
2338:
2165:
1728:
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586:
581:
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535:
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525:
4171:
4025:
3990:
3753:
2303:
1286:
1180:
1153:
1062:
1050:
512:
4159:
4055:
3782:
3644:
3470:
2861:
2738:"Air pollution and epigenetics: effects on SP-A and innate host defence in the lung"
2554:"Air pollution and epigenetics: effects on SP-A and innate host defence in the lung"
2224:
2181:
3697:
2114:
1449:
1376:
1366:
1358:
1348:
1330:
1326:
1238:
1019:
327:
106:
69:
2501:
DiAngelo S, Lin Z, Wang G, Phillips S, Ramet M, Luo J, Floros J (December 1999).
93:
4073:
Biochimica et
Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology
3991:"Shotgun sequencing of the human transcriptome with ORF expressed sequence tags"
3174:
2032:"Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2"
2000:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1982:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1838:"Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2"
1709:
1690:
1671:
1652:
1633:
1614:
1595:
1576:
1557:
1538:
1519:
1500:
1344:
1276:
1252:
1188:
1073:
3995:
Proceedings of the
National Academy of Sciences of the United States of America
3501:
3454:
3419:
3374:
3322:
3268:
3216:
2895:
2845:
2092:
2047:
1855:
410:
4113:
3199:
Silveyra P, Raval M, Simmons B, Diangelo S, Wang G, Floros J (November 2011).
2208:
1762:
1406:
1242:
1204:
1192:
1184:
1169:
1137:
1035:
226:
123:
73:
3972:
3933:
3585:
2673:
2435:
1863:
3615:
2945:
2130:
1916:
1438:
1352:
1340:
1231:
1227:
1054:
652:
470:
348:
293:
280:
192:
179:
81:
4183:
Knowledge (XXG) articles with corresponding academic peer reviewed articles
4151:
4121:
4092:
4063:
4034:
4015:
3811:
3519:
3462:
3427:
3392:
3340:
3286:
3234:
3054:
3013:
2964:
2913:
2853:
2771:
2753:
2722:
2643:
2587:
2569:
2538:
2443:
2395:
2362:"Alveolar surfactant homeostasis and the pathogenesis of pulmonary disease"
2346:
2276:
2216:
2173:
2100:
2065:
1881:
4143:
3980:
3941:
3912:
3877:
3848:
3819:
3790:
3761:
3732:
3689:
3652:
3623:
3593:
3564:
3182:
3144:
3095:
2812:
2519:
2484:
2311:
2138:
1889:
974:
969:
3045:
3028:
1812:
1757:
variation of exons A, B, C, and D. At least 10 forms of human SFTPA2 and
1372:
1311:
1299:
1161:
1157:
1105:
1101:
958:
801:
797:
778:
2995:
2880:"Surfactant protein A is defective in abrogating inflammation in asthma"
1307:
1272:
1000:
764:
719:
4188:
Knowledge (XXG) articles with corresponding articles published in Gene
4044:
American
Journal of Physiology. Lung Cellular and Molecular Physiology
3490:
American
Journal of Physiology. Lung Cellular and Molecular Physiology
3443:
American
Journal of Physiology. Lung Cellular and Molecular Physiology
3408:
American
Journal of Physiology. Lung Cellular and Molecular Physiology
3363:
American Journal of Physiology. Lung Cellular and Molecular Physiology
3311:
American Journal of Physiology. Lung Cellular and Molecular Physiology
3257:
American Journal of Physiology. Lung Cellular and Molecular Physiology
3205:
American Journal of Physiology. Lung Cellular and Molecular Physiology
3126:
2884:
American Journal of Physiology. Lung Cellular and Molecular Physiology
2834:
American Journal of Physiology. Lung Cellular and Molecular Physiology
2704:
3681:
1778:
1758:
1741:
Gene expression of SFTPA2 is regulated at different levels including
1434:
1315:
1109:
1015:
The protein encoded by this gene (SP-A2) is primarily synthesized in
942:
674:
3891:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
3074:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
2927:
Maitra M, Wang Y, Gerard RD, Mendelson CR, Garcia CK (July 2010).
1303:
1040:
2258:
2014:"Entrez Gene: SFTPA2 surfactant, pulmonary-associated protein A2"
637:
633:
3543:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2463:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
1445:
1426:
1093:
1089:
1016:
1004:
61:
3029:"DNA methylation markers of surfactant proteins in lung cancer"
3251:
Wang G, Guo X, Silveyra P, Kimball SR, Floros J (April 2009).
1806:
1117:
3484:
Bruce SR, Atkins CL, Colasurdo GN, Alcorn JL (October 2009).
1203:
SP-A2 is a protein of 248 amino acids usually found in large
1208:
recognition domain (CRD) allows binding to various types of
1144:, but no extrapulmonary SP-A immunoreactivity was observed.
3951:
American Journal of Respiratory Cell and Molecular Biology
3922:
American Journal of Respiratory Cell and Molecular Biology
3604:
American Journal of Respiratory Cell and Molecular Biology
3574:
American Journal of Respiratory Cell and Molecular Biology
3163:
American Journal of Respiratory Cell and Molecular Biology
2414:
American Journal of Respiratory Cell and Molecular Biology
2119:
American Journal of Respiratory Cell and Molecular Biology
3539:"Genetics of the hydrophilic surfactant proteins A and D"
3357:
Noutsios GT, Silveyra P, Bhatti F, Floros J (June 2013).
2459:"Genetics of the hydrophilic surfactant proteins A and D"
3885:
Karinch AM, Deiter G, Ballard PL, Floros J (June 1998).
3068:
Karinch AM, Deiter G, Ballard PL, Floros J (June 1998).
2236:
2234:
2117:(August 1998). "Collectins and pulmonary host defense".
1069:
and helps in the defense against respiratory pathogens.
317:
2496:
2494:
1022:, as part of a complex of lipids and proteins known as
2826:
2824:
2822:
2785:
deMello DE, Heyman S, Phelps DS, Floros J (May 1993).
1777:. Exon B of SFTPA2 also binds specific proteins (e.g.
2603:
2601:
2599:
2597:
1076:
is critical for breathing (and thus survival) in the
482:
2873:
2871:
903:
874:
848:
819:
2687:Wang G, Myers C, Mikerov A, Floros J (July 2007).
1956:
1954:
1952:
1935:
1933:
1931:
603:respiratory gaseous exchange by respiratory system
1745:, post-transcriptional processing, stability and
1314:. Some of the functions by which both SFTPA2 and
1092:is the main site of SFTPA2 synthesis, but SFTPA2
264:
163:
3352:
3350:
3300:
3298:
3296:
3246:
3244:
3194:
3192:
2407:
2405:
1179:Differences in the SFTPA2 gene sequence at the
1132:, the protein can be detected in lung alveolar
16:Protein-coding gene in the species Homo sapiens
3156:
3154:
2655:
2653:
2614:Critical Reviews in Eukaryotic Gene Expression
2025:
2023:
1961:GRCm38: Ensembl release 89: ENSMUSG00000021789
3305:Silveyra P, Wang G, Floros J (October 2010).
1417:Deficiency in SP-A levels is associated with
8:
4102:Pediatric Pathology & Molecular Medicine
2197:Pediatric Pathology & Molecular Medicine
1357:enhancement of pathogen-killing mechanisms:
1026:. The function of this complex is to reduce
1940:GRCh38: Ensembl release 89: ENSG00000185303
1761:5’UTRs have been identified that differ in
1168:, etc. Its expression is also regulated by
4132:Clinical Chemistry and Laboratory Medicine
994:Pulmonary surfactant-associated protein A2
648:
508:
305:
204:
101:
4024:
4014:
3962:
3902:
3722:
3554:
3509:
3382:
3330:
3276:
3224:
3134:
3085:
3044:
3003:
2954:
2944:
2903:
2802:
2761:
2712:
2633:
2577:
2528:
2518:
2474:
2425:
2385:
2327:Comparative Biochemistry and Physiology A
2266:
2055:
1871:
1096:expression has also been detected in the
2360:Whitsett JA, Wert SE, Weaver TE (2010).
1467:
1003:that in humans is encoded by the SFTPA2
1927:
2626:10.1615/critreveukargeneexpr.v19.i2.30
2030:Silveyra P, Floros J (December 2013).
18:
3537:Floros J, Hoover RR (November 1998).
2608:Floros J, Wang G, Mikerov AN (2009).
2457:Floros J, Hoover RR (November 1998).
1152:SFTPA2 is located in the long arm of
1045:Alveolar sac region of the lung - TEM
269:
230:
225:
168:
127:
122:
7:
2378:10.1146/annurev.med.60.041807.123500
1419:infant respiratory distress syndrome
1049:SP-A2 is a member of a subfamily of
608:toll-like receptor signaling pathway
3711:The Journal of Biological Chemistry
3109:Karinch AM, Floros J (April 1995).
2933:The Journal of Biological Chemistry
1836:; Joanna Floros (1 December 2013).
1183:determine SP-A genetic variants or
618:positive regulation of phagocytosis
3771:The American Journal of Physiology
3633:The American Journal of Physiology
900:
871:
845:
816:
788:
769:
743:
724:
698:
679:
487:
405:
343:
322:
14:
3033:International Journal of Oncology
2978:Vaid M, Floros J (January 2009).
2791:The American Journal of Pathology
2166:10.1034/j.1600-065x.2000.917311.x
1409:regulation of SFTPA2 expression.
557:clathrin-coated endocytic vesicle
2304:10.1146/annurev.physiol.60.1.365
1811:
1265:Modulation of the generation of
1065:found in the surface of several
253:
246:
240:
217:
152:
145:
139:
114:
4056:10.1152/ajplung.2000.278.5.l946
3783:10.1152/ajplung.1994.266.4.L354
3645:10.1152/ajplung.1989.257.6.L421
1464:SFTPA2 mRNA transcript variants
1751:five prime untranslated region
572:endoplasmic reticulum membrane
471:More reference expression data
391:right hemisphere of cerebellum
1:
4085:10.1016/S0167-4838(00)00184-9
3904:10.1016/S0167-4781(98)00047-5
3870:10.1016/S0162-3109(97)00076-3
3841:10.1016/S0378-1119(97)00411-3
3724:10.1016/S0021-9258(19)84483-6
3556:10.1016/S0925-4439(98)00077-5
3087:10.1016/S0167-4781(98)00047-5
2736:Silveyra P, Floros J (2012).
2552:Silveyra P, Floros J (2012).
2476:10.1016/S0925-4439(98)00077-5
2339:10.1016/S1095-6433(01)00325-7
2241:Silveyra P, Floros J (2012).
1281:Maintaining the structure of
238:
137:
4178:Genes on human chromosome 10
3754:10.1016/0378-1119(94)90802-8
1034:and prevent collapse during
3175:10.1165/ajrcmb.12.1.7811473
2292:Annual Review of Physiology
1846:. Gene Wiki Review Series.
1310:, and other non-biological
587:rough endoplasmic reticulum
4204:
3502:10.1152/ajplung.90507.2008
3455:10.1152/ajplung.00375.2002
3420:10.1152/ajplung.00100.2005
3375:10.1152/ajplung.00324.2012
3323:10.1152/ajplung.00113.2010
3269:10.1152/ajplung.90508.2008
3217:10.1152/ajplung.00439.2010
2896:10.1152/ajplung.00381.2010
2846:10.1152/ajplung.00249.2006
2093:10.1152/physiol.00006.2010
2048:10.1016/j.gene.2012.09.111
1856:10.1016/J.GENE.2012.09.111
531:lipopolysaccharide binding
441:sexually immature organism
4114:10.3109/15513810109168621
2366:Annual Review of Medicine
2209:10.1080/15513810109168822
1996:"Mouse PubMed Reference:"
1978:"Human PubMed Reference:"
1824:article was published in
1444:SFTPA2 genetic variants,
973:
968:
964:
957:
941:
922:
907:
878:
867:
852:
823:
812:
795:
791:
776:
772:
763:
750:
746:
731:
727:
718:
705:
701:
686:
682:
673:
658:
651:
647:
631:
511:
507:
495:
490:
481:
468:
417:
408:
383:bronchial epithelial cell
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
3973:10.1165/ajrcmb.19.4.3155
3934:10.1165/ajrcmb.19.2.3239
2674:10.2174/1570160054022935
2662:Current Pharmacogenomics
2436:10.1165/rcmb.2002-0274OC
1423:prematurely born infants
1260:proinflammatory cytokine
935:Chr 14: 40.85 – 40.86 Mb
928:Chr 10: 79.56 – 79.56 Mb
3115:The Biochemical Journal
2946:10.1074/jbc.M110.121467
2247:Frontiers in Bioscience
2131:10.1165/ajrcmb.19.2.140
1753:(5’UTR) generated from
1363:reactive oxygen species
1267:reactive oxygen species
1213:collagen-like domains.
1078:prematurely born infant
375:upper lobe of left lung
4016:10.1073/pnas.97.7.3491
3812:10.1006/geno.1993.1324
3586:10.1165/ajrcmb/6.4.446
2754:10.4414/smw.2012.13579
2570:10.4414/smw.2012.13579
1822:academic peer reviewed
1791:eukaryotic translation
1775:eukaryotic translation
1391:cell surface receptors
1046:
1020:alveolar type II cells
613:surfactant homeostasis
536:monosaccharide binding
4144:10.1515/CCLM.2002.174
3616:10.1165/ajrcmb/4.1.88
2154:Immunological Reviews
1795:translation (biology)
1771:translation (biology)
1747:translation (biology)
1458:endoplasmic reticulum
1413:Clinical significance
1389:(by interaction with
1234:, and other molecules
1126:monoclonal antibodies
1061:. SP-A2 binds to the
1044:
987:Surfactant protein A2
623:developmental process
387:cerebellar hemisphere
271:14 B|14 22.36 cM
232:Chromosome 14 (mouse)
130:Chromosome 10 (human)
3046:10.3892/ijo.31.1.181
2742:Swiss Medical Weekly
2558:Swiss Medical Weekly
1912:Surfactant protein A
1907:Pulmonary surfactant
1830:and can be cited as:
1399:antigen presentation
1335:alveolar macrophages
1247:alveolar macrophages
1142:alveolar macrophages
1130:Surfactant protein A
1059:pulmonary surfactant
1024:pulmonary surfactant
552:extracellular region
526:carbohydrate binding
4007:2000PNAS...97.3491D
3777:(4 Pt 1): L354–66.
3674:1985Natur.317..361W
2996:10.3892/or_00000182
2520:10.1155/1999/961430
1454:protein instability
1429:from patients with
1289:form of surfactant)
1134:type II pneumocytes
582:multivesicular body
577:extracellular space
3858:Immunopharmacology
3639:(6 Pt 1): L421–9.
1783:particulate matter
1767:gene transcription
1743:gene transcription
1047:
753:ENSMUSG00000021789
596:Biological process
545:Cellular component
519:Molecular function
445:pulmonary alveolus
367:upper lobe of lung
359:lower lobe of lung
94:SFTPA2 - orthologs
3127:10.1042/bj3070327
2705:10.1021/bi7004569
1898:
1897:
1834:Patricia Silveyra
1734:
1733:
1387:adaptive immunity
1084:SFTPA2 expression
984:
983:
980:
979:
953:
952:
918:
917:
897:
896:
863:
862:
842:
841:
808:
807:
785:
784:
759:
758:
740:
739:
714:
713:
695:
694:
643:
642:
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
4195:
4163:
4125:
4096:
4067:
4038:
4028:
4018:
3984:
3966:
3945:
3916:
3906:
3881:
3852:
3823:
3794:
3765:
3736:
3726:
3701:
3682:10.1038/317361a0
3656:
3627:
3597:
3568:
3558:
3524:
3523:
3513:
3481:
3475:
3474:
3438:
3432:
3431:
3403:
3397:
3396:
3386:
3354:
3345:
3344:
3334:
3302:
3291:
3290:
3280:
3248:
3239:
3238:
3228:
3196:
3187:
3186:
3158:
3149:
3148:
3138:
3121:(Pt 2): 327–30.
3106:
3100:
3099:
3089:
3065:
3059:
3058:
3048:
3024:
3018:
3017:
3007:
2984:Oncology Reports
2975:
2969:
2968:
2958:
2948:
2939:(29): 22103–13.
2924:
2918:
2917:
2907:
2875:
2866:
2865:
2828:
2817:
2816:
2806:
2782:
2776:
2775:
2765:
2733:
2727:
2726:
2716:
2684:
2678:
2677:
2657:
2648:
2647:
2637:
2605:
2592:
2591:
2581:
2549:
2543:
2542:
2532:
2522:
2498:
2489:
2488:
2478:
2454:
2448:
2447:
2429:
2409:
2400:
2399:
2389:
2357:
2351:
2350:
2322:
2316:
2315:
2287:
2281:
2280:
2270:
2238:
2229:
2228:
2192:
2186:
2185:
2149:
2143:
2142:
2111:
2105:
2104:
2076:
2070:
2069:
2059:
2027:
2018:
2017:
2010:
2004:
2003:
1992:
1986:
1985:
1974:
1968:
1958:
1947:
1937:
1893:
1875:
1815:
1807:
1468:
1329:of bacteria for
992:, also known as
966:
965:
937:
930:
913:
901:
892:
872:
868:RefSeq (protein)
858:
846:
837:
817:
789:
770:
744:
725:
699:
680:
649:
567:lamellar granule
509:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
4203:
4202:
4198:
4197:
4196:
4194:
4193:
4192:
4168:
4167:
4166:
4128:
4099:
4070:
4041:
3987:
3964:10.1.1.322.5594
3948:
3919:
3884:
3855:
3835:(1–2): 149–56.
3826:
3797:
3768:
3739:
3717:(19): 9029–33.
3704:
3668:(6035): 361–3.
3659:
3630:
3600:
3571:
3549:(2–3): 312–22.
3536:
3532:
3530:Further reading
3527:
3483:
3482:
3478:
3440:
3439:
3435:
3414:(3): L497–508.
3405:
3404:
3400:
3369:(11): L722–35.
3356:
3355:
3348:
3304:
3303:
3294:
3250:
3249:
3242:
3211:(5): L795–803.
3198:
3197:
3190:
3160:
3159:
3152:
3108:
3107:
3103:
3067:
3066:
3062:
3026:
3025:
3021:
2977:
2976:
2972:
2926:
2925:
2921:
2890:(4): L598–606.
2877:
2876:
2869:
2840:(5): L1052–63.
2830:
2829:
2820:
2784:
2783:
2779:
2735:
2734:
2730:
2699:(28): 8425–35.
2686:
2685:
2681:
2659:
2658:
2651:
2607:
2606:
2595:
2551:
2550:
2546:
2507:Disease Markers
2500:
2499:
2492:
2469:(2–3): 312–22.
2456:
2455:
2451:
2427:10.1.1.321.5856
2411:
2410:
2403:
2359:
2358:
2354:
2324:
2323:
2319:
2289:
2288:
2284:
2240:
2239:
2232:
2194:
2193:
2189:
2151:
2150:
2146:
2113:
2112:
2108:
2078:
2077:
2073:
2029:
2028:
2021:
2012:
2011:
2007:
1994:
1993:
1989:
1976:
1975:
1971:
1959:
1950:
1938:
1929:
1925:
1903:
1894:
1832:
1831:
1816:
1803:
1739:
1737:Gene regulation
1466:
1431:cystic fibrosis
1415:
1395:dendritic cells
1383:innate immunity
1347:to the site of
1339:recruitment of
1320:innate immunity
1296:
1294:Innate immunity
1258:Stimulation of
1255:of immune cells
1223:
1201:
1166:glucocorticoids
1150:
1086:
1028:surface tension
1013:
975:View/Edit Mouse
970:View/Edit Human
933:
926:
923:Location (UCSC)
909:
888:
884:
880:
854:
833:
829:
825:
800:
734:ENSG00000185303
627:
591:
540:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
421:right lung lobe
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
363:visceral pleura
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
4201:
4199:
4191:
4190:
4185:
4180:
4170:
4169:
4165:
4164:
4138:(10): 1002–8.
4126:
4097:
4068:
4050:(5): L946–54.
4039:
3985:
3946:
3917:
3897:(2): 192–202.
3882:
3864:(1–2): 73–80.
3853:
3824:
3795:
3766:
3748:(1–2): 171–4.
3737:
3702:
3657:
3628:
3598:
3569:
3533:
3531:
3528:
3526:
3525:
3496:(4): L559–67.
3476:
3449:(5): L738–48.
3433:
3398:
3346:
3317:(4): L523–34.
3292:
3263:(4): L635–47.
3240:
3188:
3150:
3101:
3080:(2): 192–202.
3060:
3019:
2970:
2919:
2867:
2818:
2797:(5): 1631–40.
2777:
2728:
2679:
2649:
2593:
2544:
2490:
2449:
2401:
2352:
2333:(1): 295–303.
2317:
2282:
2230:
2187:
2144:
2125:(2): 177–201.
2106:
2071:
2019:
2005:
1987:
1969:
1948:
1926:
1924:
1921:
1920:
1919:
1914:
1909:
1902:
1899:
1896:
1895:
1819:
1817:
1810:
1802:
1799:
1738:
1735:
1732:
1731:
1729:NM_001098668.2
1726:
1723:
1720:
1717:
1713:
1712:
1707:
1704:
1701:
1698:
1694:
1693:
1688:
1685:
1682:
1679:
1675:
1674:
1669:
1666:
1663:
1660:
1656:
1655:
1650:
1647:
1644:
1641:
1637:
1636:
1631:
1628:
1625:
1622:
1618:
1617:
1612:
1609:
1606:
1603:
1599:
1598:
1593:
1590:
1587:
1584:
1580:
1579:
1574:
1571:
1568:
1565:
1561:
1560:
1555:
1552:
1549:
1546:
1542:
1541:
1536:
1533:
1530:
1527:
1523:
1522:
1517:
1514:
1511:
1508:
1504:
1503:
1498:
1495:
1492:
1489:
1485:
1484:
1481:
1480:3’UTR sequence
1478:
1475:
1472:
1465:
1462:
1414:
1411:
1403:
1402:
1381:transition of
1379:
1375:production by
1369:
1355:
1337:
1318:contribute to
1295:
1292:
1291:
1290:
1283:tubular myelin
1279:
1269:
1263:
1256:
1249:
1235:
1222:
1219:
1210:microorganisms
1200:
1197:
1149:
1146:
1122:salivary gland
1085:
1082:
1067:microorganisms
1051:C-type lectins
1012:
1009:
982:
981:
978:
977:
972:
962:
961:
955:
954:
951:
950:
948:
946:
939:
938:
931:
924:
920:
919:
916:
915:
905:
904:
898:
895:
894:
876:
875:
869:
865:
864:
861:
860:
850:
849:
843:
840:
839:
821:
820:
814:
810:
809:
806:
805:
793:
792:
786:
783:
782:
774:
773:
767:
761:
760:
757:
756:
748:
747:
741:
738:
737:
729:
728:
722:
716:
715:
712:
711:
703:
702:
696:
693:
692:
684:
683:
677:
671:
670:
665:
660:
656:
655:
645:
644:
641:
640:
629:
628:
626:
625:
620:
615:
610:
605:
599:
597:
593:
592:
590:
589:
584:
579:
574:
569:
564:
559:
554:
548:
546:
542:
541:
539:
538:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
429:left lung lobe
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4200:
4189:
4186:
4184:
4181:
4179:
4176:
4175:
4173:
4161:
4157:
4153:
4149:
4145:
4141:
4137:
4133:
4127:
4123:
4119:
4115:
4111:
4108:(5): 367–86.
4107:
4103:
4098:
4094:
4090:
4086:
4082:
4079:(1): 159–73.
4078:
4074:
4069:
4065:
4061:
4057:
4053:
4049:
4045:
4040:
4036:
4032:
4027:
4022:
4017:
4012:
4008:
4004:
4001:(7): 3491–6.
4000:
3996:
3992:
3986:
3982:
3978:
3974:
3970:
3965:
3960:
3957:(4): 613–21.
3956:
3952:
3947:
3943:
3939:
3935:
3931:
3927:
3923:
3918:
3914:
3910:
3905:
3900:
3896:
3892:
3888:
3883:
3879:
3875:
3871:
3867:
3863:
3859:
3854:
3850:
3846:
3842:
3838:
3834:
3830:
3825:
3821:
3817:
3813:
3809:
3805:
3801:
3796:
3792:
3788:
3784:
3780:
3776:
3772:
3767:
3763:
3759:
3755:
3751:
3747:
3743:
3738:
3734:
3730:
3725:
3720:
3716:
3712:
3708:
3703:
3699:
3695:
3691:
3687:
3683:
3679:
3675:
3671:
3667:
3663:
3658:
3654:
3650:
3646:
3642:
3638:
3634:
3629:
3625:
3621:
3617:
3613:
3609:
3605:
3599:
3595:
3591:
3587:
3583:
3580:(4): 446–52.
3579:
3575:
3570:
3566:
3562:
3557:
3552:
3548:
3544:
3540:
3535:
3534:
3529:
3521:
3517:
3512:
3507:
3503:
3499:
3495:
3491:
3487:
3480:
3477:
3472:
3468:
3464:
3460:
3456:
3452:
3448:
3444:
3437:
3434:
3429:
3425:
3421:
3417:
3413:
3409:
3402:
3399:
3394:
3390:
3385:
3380:
3376:
3372:
3368:
3364:
3360:
3353:
3351:
3347:
3342:
3338:
3333:
3328:
3324:
3320:
3316:
3312:
3308:
3301:
3299:
3297:
3293:
3288:
3284:
3279:
3274:
3270:
3266:
3262:
3258:
3254:
3247:
3245:
3241:
3236:
3232:
3227:
3222:
3218:
3214:
3210:
3206:
3202:
3195:
3193:
3189:
3184:
3180:
3176:
3172:
3168:
3164:
3157:
3155:
3151:
3146:
3142:
3137:
3132:
3128:
3124:
3120:
3116:
3112:
3105:
3102:
3097:
3093:
3088:
3083:
3079:
3075:
3071:
3064:
3061:
3056:
3052:
3047:
3042:
3039:(1): 181–91.
3038:
3034:
3030:
3023:
3020:
3015:
3011:
3006:
3001:
2997:
2993:
2989:
2985:
2981:
2974:
2971:
2966:
2962:
2957:
2952:
2947:
2942:
2938:
2934:
2930:
2923:
2920:
2915:
2911:
2906:
2901:
2897:
2893:
2889:
2885:
2881:
2874:
2872:
2868:
2863:
2859:
2855:
2851:
2847:
2843:
2839:
2835:
2827:
2825:
2823:
2819:
2814:
2810:
2805:
2800:
2796:
2792:
2788:
2781:
2778:
2773:
2769:
2764:
2759:
2755:
2751:
2747:
2743:
2739:
2732:
2729:
2724:
2720:
2715:
2710:
2706:
2702:
2698:
2694:
2690:
2683:
2680:
2675:
2671:
2667:
2663:
2656:
2654:
2650:
2645:
2641:
2636:
2631:
2627:
2623:
2620:(2): 125–37.
2619:
2615:
2611:
2604:
2602:
2600:
2598:
2594:
2589:
2585:
2580:
2575:
2571:
2567:
2563:
2559:
2555:
2548:
2545:
2540:
2536:
2531:
2526:
2521:
2516:
2513:(4): 269–81.
2512:
2508:
2504:
2497:
2495:
2491:
2486:
2482:
2477:
2472:
2468:
2464:
2460:
2453:
2450:
2445:
2441:
2437:
2433:
2428:
2423:
2419:
2415:
2408:
2406:
2402:
2397:
2393:
2388:
2383:
2379:
2375:
2371:
2367:
2363:
2356:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2321:
2318:
2313:
2309:
2305:
2301:
2297:
2293:
2286:
2283:
2278:
2274:
2269:
2264:
2260:
2256:
2253:(2): 407–29.
2252:
2248:
2244:
2237:
2235:
2231:
2226:
2222:
2218:
2214:
2210:
2206:
2203:(4): 269–92.
2202:
2198:
2191:
2188:
2183:
2179:
2175:
2171:
2167:
2163:
2159:
2155:
2148:
2145:
2140:
2136:
2132:
2128:
2124:
2120:
2116:
2110:
2107:
2102:
2098:
2094:
2090:
2087:(3): 132–41.
2086:
2082:
2075:
2072:
2067:
2063:
2058:
2053:
2049:
2045:
2042:(2): 126–32.
2041:
2037:
2033:
2026:
2024:
2020:
2015:
2009:
2006:
2001:
1997:
1991:
1988:
1983:
1979:
1973:
1970:
1966:
1962:
1957:
1955:
1953:
1949:
1945:
1941:
1936:
1934:
1932:
1928:
1922:
1918:
1915:
1913:
1910:
1908:
1905:
1904:
1900:
1891:
1887:
1883:
1879:
1874:
1869:
1865:
1861:
1857:
1853:
1850:(2): 126–32.
1849:
1845:
1844:
1839:
1835:
1829:
1828:
1823:
1818:
1814:
1809:
1808:
1805:
1800:
1798:
1796:
1792:
1788:
1784:
1780:
1776:
1772:
1768:
1764:
1760:
1756:
1752:
1748:
1744:
1736:
1730:
1727:
1724:
1721:
1718:
1715:
1714:
1711:
1708:
1705:
1702:
1699:
1696:
1695:
1692:
1689:
1686:
1683:
1680:
1677:
1676:
1673:
1670:
1667:
1664:
1661:
1658:
1657:
1654:
1651:
1648:
1645:
1642:
1639:
1638:
1635:
1632:
1629:
1626:
1623:
1620:
1619:
1616:
1613:
1610:
1607:
1604:
1601:
1600:
1597:
1594:
1591:
1588:
1585:
1582:
1581:
1578:
1575:
1572:
1569:
1566:
1563:
1562:
1559:
1556:
1553:
1550:
1547:
1544:
1543:
1540:
1537:
1534:
1531:
1528:
1525:
1524:
1521:
1518:
1515:
1512:
1509:
1506:
1505:
1502:
1499:
1496:
1493:
1490:
1487:
1486:
1482:
1479:
1476:
1473:
1470:
1469:
1463:
1461:
1459:
1455:
1451:
1447:
1442:
1440:
1436:
1432:
1428:
1424:
1420:
1412:
1410:
1408:
1400:
1396:
1392:
1388:
1384:
1380:
1378:
1374:
1370:
1368:
1365:, release of
1364:
1361:, release of
1360:
1356:
1354:
1350:
1346:
1342:
1338:
1336:
1332:
1328:
1325:
1324:
1323:
1321:
1317:
1313:
1309:
1305:
1301:
1293:
1288:
1287:extracellular
1284:
1280:
1278:
1274:
1271:Serving as a
1270:
1268:
1264:
1261:
1257:
1254:
1253:proliferation
1251:Induction of
1250:
1248:
1244:
1240:
1236:
1233:
1229:
1225:
1224:
1220:
1218:
1214:
1211:
1206:
1198:
1196:
1194:
1190:
1186:
1182:
1181:coding region
1177:
1175:
1174:environmental
1171:
1167:
1163:
1159:
1155:
1154:chromosome 10
1147:
1145:
1143:
1139:
1135:
1131:
1127:
1123:
1119:
1115:
1111:
1107:
1103:
1099:
1095:
1091:
1083:
1081:
1079:
1075:
1070:
1068:
1064:
1063:carbohydrates
1060:
1056:
1052:
1043:
1039:
1037:
1033:
1029:
1025:
1021:
1018:
1010:
1008:
1006:
1002:
998:
995:
991:
988:
976:
971:
967:
963:
960:
956:
949:
947:
944:
940:
936:
932:
929:
925:
921:
914:
912:
906:
902:
899:
893:
891:
887:
883:
877:
873:
870:
866:
859:
857:
851:
847:
844:
838:
836:
832:
828:
822:
818:
815:
813:RefSeq (mRNA)
811:
804:
803:
799:
794:
790:
787:
781:
780:
775:
771:
768:
766:
762:
755:
754:
749:
745:
742:
736:
735:
730:
726:
723:
721:
717:
710:
709:
704:
700:
697:
691:
690:
685:
681:
678:
676:
672:
669:
666:
664:
661:
657:
654:
650:
646:
639:
635:
630:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
600:
598:
595:
594:
588:
585:
583:
580:
578:
575:
573:
570:
568:
565:
563:
560:
558:
555:
553:
550:
549:
547:
544:
543:
537:
534:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
437:alveolar duct
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
379:apex of heart
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
4135:
4131:
4105:
4101:
4076:
4072:
4047:
4043:
3998:
3994:
3954:
3950:
3928:(2): 202–9.
3925:
3921:
3894:
3890:
3861:
3857:
3832:
3828:
3806:(2): 294–8.
3803:
3799:
3774:
3770:
3745:
3741:
3714:
3710:
3665:
3661:
3636:
3632:
3610:(1): 88–94.
3607:
3603:
3577:
3573:
3546:
3542:
3493:
3489:
3479:
3446:
3442:
3436:
3411:
3407:
3401:
3366:
3362:
3314:
3310:
3260:
3256:
3208:
3204:
3169:(1): 77–88.
3166:
3162:
3118:
3114:
3104:
3077:
3073:
3063:
3036:
3032:
3022:
2987:
2983:
2973:
2936:
2932:
2922:
2887:
2883:
2837:
2833:
2794:
2790:
2780:
2745:
2741:
2731:
2696:
2693:Biochemistry
2692:
2682:
2668:(2): 87–95.
2665:
2661:
2617:
2613:
2561:
2557:
2547:
2510:
2506:
2466:
2462:
2452:
2420:(5): 591–7.
2417:
2413:
2369:
2365:
2355:
2330:
2326:
2320:
2295:
2291:
2285:
2259:10.2741/3935
2250:
2246:
2200:
2196:
2190:
2157:
2153:
2147:
2122:
2118:
2109:
2084:
2080:
2074:
2039:
2035:
2008:
1999:
1990:
1981:
1972:
1847:
1841:
1826:
1825:
1804:
1769:and protein
1740:
1474:5’UTR splice
1450:lung disease
1443:
1416:
1404:
1377:immune cells
1367:nitric oxide
1359:phagocytosis
1349:inflammation
1331:phagocytosis
1327:opsonization
1297:
1239:phagocytosis
1215:
1202:
1178:
1151:
1087:
1071:
1048:
1014:
996:
993:
989:
986:
985:
908:
890:NP_001307743
886:NP_001307742
882:NP_001092138
879:
853:
835:NM_001320814
831:NM_001320813
827:NM_001098668
824:
796:
777:
751:
732:
706:
687:
667:
662:
449:carotid body
333:
326:
53:External IDs
2990:(1): 3–11.
1483:GenBank id
1371:control of
1345:neutrophils
1277:parturition
1237:Increasing
1226:Binding of
1189:amino acids
1074:homeostasis
1072:Surfactant
292:40,858,409
279:40,853,739
191:79,560,407
178:79,555,852
31:Identifiers
4172:Categories
2748:: w13579.
2564:: w13579.
2372:: 105–19.
2298:: 365–84.
2081:Physiology
1967:, May 2017
1946:, May 2017
1923:References
1763:nucleotide
1471:Variant id
1407:epigenetic
1262:production
1243:chemotaxis
1205:oligomeric
1193:amino acid
1185:haplotypes
1170:epigenetic
1138:Club cells
1055:collectins
1036:expiration
371:right lung
337:(ortholog)
74:HomoloGene
3959:CiteSeerX
2422:CiteSeerX
2160:: 52–65.
2115:Crouch EC
1917:Collectin
1890:Q24621202
1864:0378-1119
1439:infection
1397:to allow
1353:infection
1341:monocytes
1322:include:
1232:allergens
1228:pathogens
1221:Functions
1199:Structure
1176:factors.
1162:microRNAs
911:NP_075623
856:NM_023134
653:Orthologs
425:left lung
82:GeneCards
4160:20022095
4152:12476938
4122:11552738
4093:11087951
4064:10781424
4035:10737800
3800:Genomics
3520:19525387
3471:13268207
3463:12676764
3428:15894557
3393:23525782
3341:20693318
3287:19181744
3235:21840962
3055:17549420
3014:19082436
2965:20466729
2914:21784968
2862:21421799
2854:17189324
2772:22553125
2723:17580966
2644:19392648
2588:22553125
2539:10689550
2444:12777246
2396:19824815
2347:11369553
2277:22201752
2225:19109567
2217:11486734
2182:22948014
2174:10719667
2101:20551227
2066:23069847
1963:–
1942:–
1901:See also
1886:Wikidata
1882:23069847
1787:splicing
1785:affects
1755:splicing
1710:HQ021431
1691:HQ021430
1672:HQ021429
1653:HQ021428
1634:HQ021427
1615:HQ021426
1596:HQ021425
1577:HQ021424
1558:HQ021423
1539:HQ021422
1520:HQ021421
1501:HQ021432
1373:cytokine
1312:antigens
1300:bacteria
1106:pancreas
1102:prostate
1032:alveolus
997:(PSP-A2)
959:Wikidata
632:Sources:
562:collagen
4003:Bibcode
3981:9761758
3942:9698591
3913:9689918
3878:9476117
3849:9373149
3820:8406480
3791:8179012
3762:8125298
3733:3755136
3698:4357498
3690:2995821
3670:Bibcode
3653:2610270
3624:1986781
3594:1372511
3565:9813381
3511:2770795
3384:3680765
3332:2957414
3278:2670766
3226:3290452
3183:7811473
3145:7733864
3136:1136651
3096:9689918
3005:2899699
2956:2903395
2905:3191759
2813:8494055
2804:1886897
2763:3601480
2714:2531219
2635:2967201
2579:3601480
2530:3851098
2485:9813381
2387:4127631
2312:9558469
2268:3635489
2139:9698590
2057:3570704
1965:Ensembl
1944:Ensembl
1873:3570704
1308:viruses
1273:hormone
1098:trachea
1053:called
1030:in the
1011:Summary
1001:protein
990:(SP-A2)
765:UniProt
720:Ensembl
659:Species
638:QuickGO
433:trachea
395:trachea
312:pattern
170:10q22.3
38:Aliases
4158:
4150:
4120:
4091:
4062:
4033:
4023:
3979:
3961:
3940:
3911:
3876:
3847:
3818:
3789:
3760:
3731:
3696:
3688:
3662:Nature
3651:
3622:
3592:
3563:
3518:
3508:
3469:
3461:
3426:
3391:
3381:
3339:
3329:
3285:
3275:
3233:
3223:
3181:
3143:
3133:
3094:
3053:
3012:
3002:
2963:
2953:
2912:
2902:
2860:
2852:
2811:
2801:
2770:
2760:
2721:
2711:
2642:
2632:
2586:
2576:
2537:
2527:
2483:
2442:
2424:
2394:
2384:
2345:
2310:
2275:
2265:
2223:
2215:
2180:
2172:
2137:
2099:
2064:
2054:
1888:
1880:
1870:
1862:
1779:14-3-3
1759:SFTPA1
1716:SFTPA2
1697:ABD'1A
1678:ABD'1A
1659:ABD'1A
1640:ABD'1A
1621:ABD'1A
1602:ABD'1A
1477:Coding
1437:, and
1435:asthma
1316:SFTPA1
1140:, and
1110:thymus
945:search
943:PubMed
802:Q9CQI1
798:P35242
779:Q8IWL1
689:729238
675:Entrez
483:BioGPS
86:SFTPA2
78:121995
70:109518
62:178642
45:SFTPA2
22:SFTPA2
4156:S2CID
4026:16267
3694:S2CID
3467:S2CID
2858:S2CID
2221:S2CID
2178:S2CID
1827:Gene
1801:Notes
1583:ABD1A
1564:ABD1A
1545:ABD1A
1526:ABD1A
1507:ABD1A
1488:ABD1A
1304:fungi
1158:5'UTR
1114:colon
999:is a
708:20387
668:Mouse
663:Human
634:Amigo
457:liver
453:aorta
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
4148:PMID
4118:PMID
4089:PMID
4077:1543
4060:PMID
4031:PMID
3977:PMID
3938:PMID
3909:PMID
3895:1398
3874:PMID
3845:PMID
3829:Gene
3816:PMID
3787:PMID
3758:PMID
3742:Gene
3729:PMID
3686:PMID
3649:PMID
3620:PMID
3590:PMID
3561:PMID
3547:1408
3516:PMID
3459:PMID
3424:PMID
3389:PMID
3337:PMID
3283:PMID
3231:PMID
3179:PMID
3141:PMID
3092:PMID
3078:1398
3051:PMID
3010:PMID
2961:PMID
2910:PMID
2850:PMID
2809:PMID
2768:PMID
2719:PMID
2640:PMID
2584:PMID
2535:PMID
2481:PMID
2467:1408
2440:PMID
2392:PMID
2343:PMID
2308:PMID
2273:PMID
2213:PMID
2170:PMID
2135:PMID
2097:PMID
2062:PMID
2036:Gene
1878:PMID
1860:ISSN
1843:Gene
1719:ABD’
1700:ABD'
1681:ABD'
1662:ABD'
1643:ABD'
1624:ABD'
1605:ABD'
1456:and
1446:SNPs
1427:BALF
1343:and
1285:(an
1241:and
1172:and
1148:Gene
1128:for
1094:mRNA
1090:lung
1088:The
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