29:
2926:
746:
Iwahashi H, Eguchi Y, Yasuhara N, Hanafusa T, Matsuzawa Y, Tsujimoto Y (November 1997). "Synergistic anti-apoptotic activity between Bcl-2 and SMN implicated in spinal muscular atrophy".
1637:
400:
1890:
1393:"Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?"
606:"Neuronal-specific roles of the survival motor neuron protein: evidence from survival motor neuron expression patterns in the developing human central nervous system"
146:
1132:
Williams BY, Hamilton SL, Sarkar HK (March 2000). "The survival motor neuron protein interacts with the transactivator FUSE binding protein from human fetal brain".
1630:
282:. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small
520:
Selenko P, Sprangers R, Stier G, Bühler D, Fischer U, Sattler M (January 2001). "SMN tudor domain structure and its interaction with the Sm proteins".
890:"Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins"
1623:
2235:
1565:"Fungal Smn and Spf30 homologues are mainly present in filamentous fungi and genomes with many introns: implications for spinal muscular atrophy"
1524:"Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN)"
388:
94:
1180:"The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins"
2453:
448:
442:
2490:
557:"A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy"
2969:
984:"Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems"
1646:
1846:
166:
2059:
1483:"A direct interaction between the survival motor neuron protein and p53 and its relationship to spinal muscular atrophy"
394:
2004:
350:
1605:
2860:
219:
2944:
2698:
2681:
2676:
2671:
2666:
2661:
1609:
1434:"SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta"
418:
338:
334:
330:
326:
318:
317:. The complex, apart from the "proper" survival of motor neuron protein, includes at least six other proteins (
255:
1303:"Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component"
154:
2269:
247:
2441:
2310:
1262:"Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex"
2964:
2483:
1691:
150:
1141:
1096:
1085:"The survival of motor neurons (SMN) protein interacts with the snoRNP proteins fibrillarin and GAR1"
755:
107:
2468:
1654:
2621:
2300:
1668:
251:
1970:
1584:
1545:
1504:
1463:
1414:
1373:
1324:
1283:
1242:
1201:
1157:
1114:
1062:
1013:
964:
911:
861:
812:
771:
728:
676:
627:
586:
537:
488:
283:
141:
2512:
2476:
2230:
2189:
2184:
2159:
2149:
2144:
2134:
1934:
1576:
1535:
1494:
1453:
1445:
1404:
1363:
1355:
1314:
1273:
1232:
1191:
1149:
1104:
1052:
1044:
1003:
995:
954:
946:
901:
851:
843:
802:
763:
720:
666:
658:
617:
576:
568:
529:
227:
2205:
2139:
832:"Coilin forms the bridge between Cajal bodies and SMN, the spinal muscular atrophy protein"
477:
133:
2715:
2504:
2436:
1659:
1033:"A functional interaction between the survival motor neuron complex and RNA polymerase II"
982:
Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999).
930:
500:
474:
1145:
1100:
759:
622:
605:
2891:
2561:
2517:
1983:
1978:
1458:
1433:
1391:
Rossoll W, Kröning AK, Ohndorf UM, Steegborn C, Jablonka S, Sendtner M (January 2002).
1221:"Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins"
1057:
1032:
1008:
983:
671:
646:
581:
556:
1368:
1343:
1196:
1179:
1153:
1109:
1084:
959:
934:
856:
831:
807:
790:
28:
2958:
888:
Meister G, Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (August 2000).
267:
99:
286:(snRNPs). This protein forms heteromeric complexes with proteins such as GEMIN2 and
62:
2745:
2525:
2500:
2339:
2321:
1219:
Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (February 2002).
279:
271:
243:
239:
215:
212:
129:
75:
1615:
87:
2897:
2760:
2750:
2633:
2531:
2415:
2283:
724:
382:
314:
1580:
1359:
2838:
2651:
2245:
1673:
662:
291:
223:
1449:
2791:
2740:
2643:
1993:
1939:
1481:
Young PJ, Day PM, Zhou J, Androphy EJ, Morris GE, Lorson CL (January 2002).
906:
889:
480:
275:
35:
1588:
1549:
1540:
1523:
1508:
1499:
1482:
1467:
1418:
1377:
1328:
1319:
1302:
1287:
1278:
1261:
1246:
1237:
1220:
1161:
1118:
1066:
1031:
Pellizzoni L, Charroux B, Rappsilber J, Mann M, Dreyfuss G (January 2001).
1017:
999:
968:
935:"miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs"
915:
865:
816:
732:
680:
631:
590:
541:
1409:
1392:
1205:
789:
Hebert MD, Shpargel KB, Ospina JK, Tucker KE, Matera AG (September 2002).
775:
647:"The survival motor neuron protein forms soluble glycine zipper oligomers"
103:
2720:
2273:
1906:
1898:
1048:
694:
572:
231:
82:
1260:
Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (August 2002).
2769:
2024:
1911:
1871:
1802:
1797:
1792:
1787:
1782:
1737:
1301:
Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002).
950:
847:
484:
309:
refers to the entire multi-protein complex involved in the assembly of
298:, such as hnRNP U protein and the small nucleolar RNA binding protein.
290:, and also interacts with several proteins known to be involved in the
190:
1344:"SMN interacts with a novel family of hnRNP and spliceosomal proteins"
2821:
2811:
2801:
2796:
2708:
2691:
2626:
2616:
2611:
2606:
2601:
2596:
2591:
2586:
2240:
2215:
2210:
2200:
2164:
2154:
2129:
2114:
2109:
2104:
2099:
2094:
2089:
2084:
2079:
2044:
2029:
1876:
1841:
1826:
1821:
1816:
1777:
1772:
1767:
1762:
1757:
1752:
1747:
1742:
1732:
1727:
1722:
1717:
1712:
466:
424:
412:
406:
364:
287:
161:
1342:
Mourelatos Z, Abel L, Yong J, Kataoka N, Dreyfuss G (October 2001).
645:
Martin R, Gupta K, Ninan NS, Perry K, Van Duyne GD (November 2012).
1564:
1432:
Narayanan U, Ospina JK, Frey MR, Hebert MD, Matera AG (July 2002).
2911:
2816:
2806:
2779:
2774:
2703:
2686:
2581:
2576:
2571:
2566:
2556:
2551:
2546:
2541:
2536:
2431:
2421:
2411:
2396:
2378:
2373:
2368:
2363:
2295:
2255:
2220:
2194:
2179:
2174:
2169:
2124:
2119:
2074:
2069:
2064:
2034:
2019:
1916:
1885:
1866:
1861:
1856:
1851:
1836:
1831:
1811:
1707:
1700:
1696:
1686:
1681:
929:
Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L,
767:
533:
462:
430:
370:
358:
322:
310:
295:
211:
SMN is found in the cytoplasm of all animal cells and also in the
2876:
2871:
2848:
2843:
2831:
2826:
2784:
2446:
2426:
2406:
2401:
2351:
2334:
2290:
2278:
2260:
2250:
2049:
2039:
2014:
2009:
1954:
1949:
376:
205:
201:
195:
123:
69:
57:
2472:
1619:
830:
Hebert MD, Szymczyk PW, Shpargel KB, Matera AG (October 2001).
555:
Singh NN, Shishimorova M, Cao LC, Gangwani L, Singh RN (2009).
436:
711:
Gubitz AK, Feng W, Dreyfuss G (May 2004). "The SMN complex".
465:
kingdom, though only fungal organisms with a great number of
1083:
Pellizzoni L, Baccon J, Charroux B, Dreyfuss G (July 2001).
604:
Giavazzi A, Setola V, Simonati A, Battaglia G (March 2006).
695:"Entrez Gene: SMN1 survival of motor neuron 1, telomeric"
483:). Surprisingly, these are filamentous fungus which have
1178:
Liu Q, Fischer U, Wang F, Dreyfuss G (September 1997).
791:"Coilin methylation regulates nuclear body formation"
610:
2859:
2759:
2729:
2642:
2511:
2389:
2320:
2309:
1992:
1969:
1927:
1667:
1653:
160:
140:
122:
117:
93:
81:
68:
56:
48:
43:
21:
2927:transcription factors and intracellular receptors
250:. Research also showed a possible role of SMN in
1078:
1076:
883:
881:
879:
877:
875:
1173:
1171:
461:SMN is evolutionarily conserved including the
2484:
1631:
274:and YG-Box domains. It localizes to both the
8:
2733:
2491:
2477:
2469:
2317:
1664:
1638:
1624:
1616:
114:
27:
1608:at the U.S. National Library of Medicine
1539:
1498:
1457:
1408:
1367:
1318:
1277:
1236:
1195:
1108:
1056:
1007:
958:
905:
855:
806:
670:
621:
580:
1563:Mier P, Pérez-Pulido AJ (January 2012).
706:
704:
512:
1522:Friesen WJ, Dreyfuss G (August 2000).
18:
1606:SMN+protein+(spinal+muscular+atrophy)
7:
1528:The Journal of Biological Chemistry
1487:The Journal of Biological Chemistry
1307:The Journal of Biological Chemistry
1266:The Journal of Biological Chemistry
1225:The Journal of Biological Chemistry
933:, Mann M, Dreyfuss G (March 2002).
623:10.1097/01.jnen.0000205144.54457.a3
230:. SMN deficiency, primarily due to
2454:Prokaryotic ubiquitin-like protein
14:
193:that in humans is encoded by the
33:Tudor domain from human SMN. PDB
1984:Mitochondrial targeting signal
1647:Posttranslational modification
313:, the essential components of
242:defects, especially in spinal
1:
1197:10.1016/S0092-8674(00)80367-0
1154:10.1016/S0014-5793(00)01320-X
1110:10.1016/S0960-9822(01)00316-5
808:10.1016/S1534-5807(02)00222-8
118:Available protein structures:
22:Survival motor neuron protein
2060:Ubiquitin-conjugating enzyme
2348:E2 SUMO-conjugating enzyme
2005:Ubiquitin-activating enzyme
1037:The Journal of Cell Biology
988:The Journal of Cell Biology
725:10.1016/j.yexcr.2004.03.022
2986:
2861:Transition nuclear protein
2331:E1 SUMO-activating enzyme
1581:10.1016/j.gene.2011.10.006
713:Experimental Cell Research
220:transcriptional regulation
2940:
2920:
2907:
2887:
2736:
2699:Perinucleolar compartment
663:10.1016/j.str.2012.08.024
522:Nature Structural Biology
457:Evolutionary conservation
266:The SMN protein contains
113:
26:
1945:Survival of motor neuron
1610:Medical Subject Headings
1438:Human Molecular Genetics
1397:Human Molecular Genetics
1360:10.1093/emboj/20.19.5443
894:Human Molecular Genetics
319:gem-associated protein 2
238:, results in widespread
179:Survival of motor neuron
2970:Spinal muscular atrophy
2311:Ubiquitin-like proteins
2270:Deubiquitinating enzyme
939:Genes & Development
836:Genes & Development
491:to the neuronal axons.
248:spinal muscular atrophy
16:Protein in animal cells
1541:10.1074/jbc.M003299200
1500:10.1074/jbc.M108769200
1450:10.1093/hmg/11.15.1785
1320:10.1074/jbc.M110141200
1279:10.1074/jbc.M203478200
1238:10.1074/jbc.M109448200
1000:10.1083/jcb.147.6.1181
349:SMN has been shown to
315:spliceosomal machinery
246:, and is one cause of
907:10.1093/hmg/9.13.1977
183:survival motor neuron
1049:10.1083/jcb.152.1.75
573:10.4161/rna.6.3.8723
228:cellular trafficking
2652:Cajal (coiled) body
2513:Envelope (membrane)
1669:Heat shock proteins
1410:10.1093/hmg/11.1.93
1146:2000FEBSL.470..207W
1101:2001CBio...11.1079P
760:1997Natur.390..413I
2499:Structures of the
951:10.1101/gad.974702
848:10.1101/gad.908401
795:Developmental Cell
284:ribonucleoproteins
252:neuronal migration
218:. It functions in
2952:
2951:
2936:
2935:
2466:
2465:
2462:
2461:
1971:Protein targeting
1965:
1964:
226:regeneration and
176:
175:
172:
171:
167:structure summary
2977:
2945:nucleus diseases
2894:(Nucleoskeleton)
2734:
2493:
2486:
2479:
2470:
2318:
2231:Ubiquitin ligase
1997:(ubiquitylation)
1935:Alpha crystallin
1665:
1640:
1633:
1626:
1617:
1593:
1592:
1560:
1554:
1553:
1543:
1519:
1513:
1512:
1502:
1478:
1472:
1471:
1461:
1429:
1423:
1422:
1412:
1388:
1382:
1381:
1371:
1348:The EMBO Journal
1339:
1333:
1332:
1322:
1298:
1292:
1291:
1281:
1272:(35): 31957–62.
1257:
1251:
1250:
1240:
1216:
1210:
1209:
1199:
1175:
1166:
1165:
1129:
1123:
1122:
1112:
1080:
1071:
1070:
1060:
1028:
1022:
1021:
1011:
979:
973:
972:
962:
926:
920:
919:
909:
885:
870:
869:
859:
827:
821:
820:
810:
786:
780:
779:
743:
737:
736:
708:
699:
698:
691:
685:
684:
674:
642:
636:
635:
625:
601:
595:
594:
584:
552:
546:
545:
517:
487:, so suggesting
115:
38:
31:
19:
2985:
2984:
2980:
2979:
2978:
2976:
2975:
2974:
2955:
2954:
2953:
2948:
2932:
2916:
2903:
2883:
2855:
2755:
2725:
2638:
2516:
2507:
2505:nuclear protein
2497:
2467:
2458:
2385:
2360:E3 SUMO ligase
2324:
2313:
2305:
1996:
1988:
1961:
1923:
1902:
1894:
1672:
1660:protein folding
1658:
1649:
1644:
1602:
1597:
1596:
1562:
1561:
1557:
1534:(34): 26370–5.
1521:
1520:
1516:
1480:
1479:
1475:
1444:(15): 1785–95.
1431:
1430:
1426:
1390:
1389:
1385:
1354:(19): 5443–52.
1341:
1340:
1336:
1300:
1299:
1295:
1259:
1258:
1254:
1218:
1217:
1213:
1177:
1176:
1169:
1131:
1130:
1126:
1095:(14): 1079–88.
1089:Current Biology
1082:
1081:
1074:
1030:
1029:
1025:
981:
980:
976:
928:
927:
923:
900:(13): 1977–86.
887:
886:
873:
829:
828:
824:
788:
787:
783:
754:(6658): 413–7.
745:
744:
740:
710:
709:
702:
693:
692:
688:
657:(11): 1929–39.
644:
643:
639:
603:
602:
598:
554:
553:
549:
519:
518:
514:
509:
501:Gideon Dreyfuss
497:
475:splicing factor
459:
454:
347:
304:
264:
256:differentiation
39:
34:
17:
12:
11:
5:
2983:
2981:
2973:
2972:
2967:
2957:
2956:
2950:
2949:
2941:
2938:
2937:
2934:
2933:
2931:
2930:
2921:
2918:
2917:
2915:
2914:
2908:
2905:
2904:
2902:
2901:
2895:
2892:Nuclear matrix
2888:
2885:
2884:
2882:
2881:
2880:
2879:
2874:
2866:
2864:
2857:
2856:
2854:
2853:
2852:
2851:
2846:
2836:
2835:
2834:
2829:
2824:
2819:
2814:
2809:
2804:
2799:
2789:
2788:
2787:
2782:
2777:
2766:
2764:
2757:
2756:
2754:
2753:
2748:
2746:Dot (PML body)
2743:
2737:
2731:
2727:
2726:
2724:
2723:
2718:
2713:
2712:
2711:
2706:
2696:
2695:
2694:
2689:
2684:
2679:
2674:
2669:
2664:
2659:
2648:
2646:
2640:
2639:
2637:
2636:
2631:
2630:
2629:
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
2584:
2579:
2574:
2569:
2564:
2559:
2554:
2549:
2544:
2539:
2529:
2522:
2520:
2518:nuclear lamina
2509:
2508:
2498:
2496:
2495:
2488:
2481:
2473:
2464:
2463:
2460:
2459:
2457:
2456:
2450:
2449:
2444:
2439:
2434:
2429:
2424:
2419:
2409:
2404:
2399:
2393:
2391:
2387:
2386:
2384:
2383:
2382:
2381:
2376:
2371:
2366:
2357:
2356:
2355:
2354:
2345:
2344:
2343:
2342:
2337:
2328:
2326:
2315:
2307:
2306:
2304:
2303:
2298:
2293:
2287:
2286:
2281:
2276:
2266:
2265:
2264:
2263:
2258:
2253:
2248:
2243:
2238:
2226:
2225:
2224:
2223:
2218:
2213:
2208:
2203:
2198:
2192:
2187:
2182:
2177:
2172:
2167:
2162:
2157:
2152:
2147:
2142:
2137:
2132:
2127:
2122:
2117:
2112:
2107:
2102:
2097:
2092:
2087:
2082:
2077:
2072:
2067:
2055:
2054:
2053:
2052:
2047:
2042:
2037:
2032:
2027:
2022:
2017:
2012:
2000:
1998:
1990:
1989:
1987:
1986:
1981:
1979:Signal peptide
1975:
1973:
1967:
1966:
1963:
1962:
1960:
1959:
1958:
1957:
1952:
1942:
1937:
1931:
1929:
1925:
1924:
1922:
1921:
1920:
1919:
1914:
1909:
1904:
1900:
1896:
1892:
1882:
1881:
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1879:
1874:
1869:
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1829:
1824:
1819:
1808:
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1800:
1795:
1790:
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1775:
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1765:
1760:
1755:
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1745:
1740:
1735:
1730:
1725:
1720:
1715:
1704:
1703:
1694:
1689:
1684:
1678:
1676:
1662:
1651:
1650:
1645:
1643:
1642:
1635:
1628:
1620:
1614:
1613:
1601:
1600:External links
1598:
1595:
1594:
1555:
1514:
1473:
1424:
1383:
1334:
1293:
1252:
1211:
1190:(6): 1013–21.
1167:
1124:
1072:
1023:
994:(6): 1181–94.
974:
921:
871:
842:(20): 2720–9.
822:
781:
738:
700:
686:
637:
596:
547:
511:
510:
508:
505:
504:
503:
496:
493:
458:
455:
453:
452:
446:
440:
434:
428:
422:
416:
410:
404:
398:
392:
386:
380:
374:
368:
362:
355:
346:
343:
303:
300:
263:
260:
174:
173:
170:
169:
164:
158:
157:
144:
138:
137:
127:
120:
119:
111:
110:
97:
91:
90:
85:
79:
78:
73:
66:
65:
60:
54:
53:
50:
46:
45:
41:
40:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2982:
2971:
2968:
2966:
2963:
2962:
2960:
2947:
2946:
2939:
2929:
2928:
2923:
2922:
2919:
2913:
2910:
2909:
2906:
2899:
2896:
2893:
2890:
2889:
2886:
2878:
2875:
2873:
2870:
2869:
2868:
2867:
2865:
2862:
2858:
2850:
2847:
2845:
2842:
2841:
2840:
2837:
2833:
2830:
2828:
2825:
2823:
2820:
2818:
2815:
2813:
2810:
2808:
2805:
2803:
2800:
2798:
2795:
2794:
2793:
2790:
2786:
2783:
2781:
2778:
2776:
2773:
2772:
2771:
2768:
2767:
2765:
2762:
2758:
2752:
2749:
2747:
2744:
2742:
2739:
2738:
2735:
2732:
2728:
2722:
2719:
2717:
2714:
2710:
2707:
2705:
2702:
2701:
2700:
2697:
2693:
2690:
2688:
2685:
2683:
2680:
2678:
2675:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2654:
2653:
2650:
2649:
2647:
2645:
2641:
2635:
2632:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2534:
2533:
2530:
2527:
2524:
2523:
2521:
2519:
2514:
2510:
2506:
2502:
2494:
2489:
2487:
2482:
2480:
2475:
2474:
2471:
2455:
2452:
2451:
2448:
2445:
2443:
2440:
2438:
2435:
2433:
2430:
2428:
2425:
2423:
2420:
2417:
2413:
2410:
2408:
2405:
2403:
2400:
2398:
2395:
2394:
2392:
2388:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2361:
2359:
2358:
2353:
2350:
2349:
2347:
2346:
2341:
2338:
2336:
2333:
2332:
2330:
2329:
2327:
2325:(SUMOylation)
2323:
2319:
2316:
2312:
2308:
2302:
2299:
2297:
2294:
2292:
2289:
2288:
2285:
2282:
2280:
2277:
2275:
2271:
2268:
2267:
2262:
2259:
2257:
2254:
2252:
2249:
2247:
2244:
2242:
2239:
2237:
2234:
2233:
2232:
2228:
2227:
2222:
2219:
2217:
2214:
2212:
2209:
2207:
2204:
2202:
2199:
2196:
2193:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2156:
2153:
2151:
2148:
2146:
2143:
2141:
2138:
2136:
2133:
2131:
2128:
2126:
2123:
2121:
2118:
2116:
2113:
2111:
2108:
2106:
2103:
2101:
2098:
2096:
2093:
2091:
2088:
2086:
2083:
2081:
2078:
2076:
2073:
2071:
2068:
2066:
2063:
2062:
2061:
2057:
2056:
2051:
2048:
2046:
2043:
2041:
2038:
2036:
2033:
2031:
2028:
2026:
2023:
2021:
2018:
2016:
2013:
2011:
2008:
2007:
2006:
2002:
2001:
1999:
1995:
1991:
1985:
1982:
1980:
1977:
1976:
1974:
1972:
1968:
1956:
1953:
1951:
1948:
1947:
1946:
1943:
1941:
1938:
1936:
1933:
1932:
1930:
1926:
1918:
1915:
1913:
1910:
1908:
1905:
1903:
1897:
1895:
1889:
1888:
1887:
1884:
1883:
1878:
1875:
1873:
1870:
1868:
1865:
1863:
1860:
1858:
1855:
1853:
1850:
1848:
1845:
1843:
1840:
1838:
1835:
1833:
1830:
1828:
1825:
1823:
1820:
1818:
1815:
1814:
1813:
1810:
1809:
1804:
1801:
1799:
1796:
1794:
1791:
1789:
1786:
1784:
1781:
1779:
1776:
1774:
1771:
1769:
1766:
1764:
1761:
1759:
1756:
1754:
1751:
1749:
1746:
1744:
1741:
1739:
1736:
1734:
1731:
1729:
1726:
1724:
1721:
1719:
1716:
1714:
1711:
1710:
1709:
1706:
1705:
1702:
1698:
1695:
1693:
1690:
1688:
1685:
1683:
1680:
1679:
1677:
1675:
1670:
1666:
1663:
1661:
1656:
1652:
1648:
1641:
1636:
1634:
1629:
1627:
1622:
1621:
1618:
1611:
1607:
1604:
1603:
1599:
1590:
1586:
1582:
1578:
1575:(2): 135–41.
1574:
1570:
1566:
1559:
1556:
1551:
1547:
1542:
1537:
1533:
1529:
1525:
1518:
1515:
1510:
1506:
1501:
1496:
1493:(4): 2852–9.
1492:
1488:
1484:
1477:
1474:
1469:
1465:
1460:
1455:
1451:
1447:
1443:
1439:
1435:
1428:
1425:
1420:
1416:
1411:
1406:
1403:(1): 93–105.
1402:
1398:
1394:
1387:
1384:
1379:
1375:
1370:
1365:
1361:
1357:
1353:
1349:
1345:
1338:
1335:
1330:
1326:
1321:
1316:
1313:(9): 7540–5.
1312:
1308:
1304:
1297:
1294:
1289:
1285:
1280:
1275:
1271:
1267:
1263:
1256:
1253:
1248:
1244:
1239:
1234:
1231:(7): 5631–6.
1230:
1226:
1222:
1215:
1212:
1207:
1203:
1198:
1193:
1189:
1185:
1181:
1174:
1172:
1168:
1163:
1159:
1155:
1151:
1147:
1143:
1140:(2): 207–10.
1139:
1135:
1128:
1125:
1120:
1116:
1111:
1106:
1102:
1098:
1094:
1090:
1086:
1079:
1077:
1073:
1068:
1064:
1059:
1054:
1050:
1046:
1042:
1038:
1034:
1027:
1024:
1019:
1015:
1010:
1005:
1001:
997:
993:
989:
985:
978:
975:
970:
966:
961:
956:
952:
948:
944:
940:
936:
932:
925:
922:
917:
913:
908:
903:
899:
895:
891:
884:
882:
880:
878:
876:
872:
867:
863:
858:
853:
849:
845:
841:
837:
833:
826:
823:
818:
814:
809:
804:
801:(3): 329–37.
800:
796:
792:
785:
782:
777:
773:
769:
768:10.1038/37144
765:
761:
757:
753:
749:
742:
739:
734:
730:
726:
722:
718:
714:
707:
705:
701:
696:
690:
687:
682:
678:
673:
668:
664:
660:
656:
652:
648:
641:
638:
633:
629:
624:
619:
616:(3): 267–77.
615:
611:
607:
600:
597:
592:
588:
583:
578:
574:
570:
567:(3): 341–50.
566:
562:
558:
551:
548:
543:
539:
535:
534:10.1038/83014
531:
527:
523:
516:
513:
506:
502:
499:
498:
494:
492:
490:
486:
482:
479:
476:
473:gene (or the
472:
468:
464:
456:
450:
447:
444:
441:
438:
435:
432:
429:
426:
423:
420:
417:
414:
411:
408:
405:
402:
399:
396:
393:
390:
387:
384:
381:
378:
375:
372:
369:
366:
363:
360:
357:
356:
354:
352:
344:
342:
340:
336:
332:
328:
324:
320:
316:
312:
308:
301:
299:
297:
293:
289:
285:
281:
277:
273:
269:
261:
259:
257:
253:
249:
245:
244:motor neurons
241:
237:
233:
229:
225:
221:
217:
214:
209:
207:
204:
203:
198:
197:
192:
188:
184:
180:
168:
165:
163:
159:
156:
152:
148:
145:
143:
139:
135:
131:
128:
125:
121:
116:
112:
109:
105:
101:
98:
96:
92:
89:
86:
84:
80:
77:
74:
71:
67:
64:
61:
59:
55:
51:
47:
42:
37:
30:
25:
20:
2965:Motor system
2942:
2924:
2656:
2526:Pore complex
2501:cell nucleus
2322:SUMO protein
1944:
1572:
1568:
1558:
1531:
1527:
1517:
1490:
1486:
1476:
1441:
1437:
1427:
1400:
1396:
1386:
1351:
1347:
1337:
1310:
1306:
1296:
1269:
1265:
1255:
1228:
1224:
1214:
1187:
1183:
1137:
1134:FEBS Letters
1133:
1127:
1092:
1088:
1043:(1): 75–85.
1040:
1036:
1026:
991:
987:
977:
945:(6): 720–8.
942:
938:
931:Rappsilber J
924:
897:
893:
839:
835:
825:
798:
794:
784:
751:
747:
741:
716:
712:
689:
654:
650:
640:
613:
609:
599:
564:
560:
550:
528:(1): 27–31.
525:
521:
515:
470:
460:
348:
345:Interactions
306:
305:
265:
235:
210:
200:
194:
186:
182:
178:
177:
2900:(Nucleosol)
2898:Nucleoplasm
2761:SMC protein
2751:Paraspeckle
2532:Nucleoporin
2416:neddylation
1682:Hsp10/GroES
1674:Chaperonins
719:(1): 51–6.
561:RNA Biology
307:SMN complex
302:SMN complex
44:Identifiers
2959:Categories
2839:DNA repair
1708:Hsp40/DnaJ
1655:Chaperones
507:References
292:biogenesis
270:-binding,
224:telomerase
130:structures
2943:see also
2925:see also
2792:Condensin
2741:Chromatin
2644:Nucleolus
1994:Ubiquitin
1940:Clusterin
651:Structure
481:paralogue
469:have the
276:cytoplasm
232:mutations
88:IPR010304
2274:Ataxin 3
1589:22020225
1550:10851237
1509:11704667
1468:12095920
1419:11773003
1378:11574476
1329:11748230
1288:12065586
1247:11714716
1162:10734235
1119:11509230
1067:11149922
1018:10601333
969:11914277
916:10942426
866:11641277
817:12361597
733:15120993
681:23022347
632:16651888
591:19430205
542:11135666
495:See also
351:interact
278:and the
262:Function
240:splicing
147:RCSB PDB
83:InterPro
2770:Cohesin
2197:(CDC34)
1459:1630493
1206:9323129
1142:Bibcode
1097:Bibcode
1058:2193649
1009:2168095
776:9389483
756:Bibcode
672:3519385
582:2734876
489:analogy
485:mycelia
467:introns
280:nucleus
254:and/or
213:nuclear
191:protein
189:) is a
63:PF06003
2822:NCAPH2
2812:NCAPG2
2802:NCAPD3
2797:NCAPD2
2709:CUGBP1
2682:GEMIN7
2677:GEMIN6
2672:GEMIN5
2667:GEMIN4
2662:GEMIN2
2627:NUP214
2622:NUP210
2617:NUP205
2612:NUP188
2607:NUP160
2602:NUP155
2597:NUP153
2592:NUP133
2587:NUP107
2241:Cullin
1612:(MeSH)
1587:
1548:
1507:
1466:
1456:
1417:
1376:
1369:125643
1366:
1327:
1286:
1245:
1204:
1160:
1117:
1065:
1055:
1016:
1006:
967:
960:155365
957:
914:
864:
857:312817
854:
815:
774:
748:Nature
731:
679:
669:
630:
589:
579:
540:
449:SNRPD2
445:, and
443:SNRPD1
425:HNRNPR
419:GEMIN7
413:GEMIN5
407:GEMIN4
401:GEMIN2
365:Coilin
353:with:
311:snRNPs
296:snRNPs
288:GEMIN4
268:GEMIN2
162:PDBsum
136:
126:
108:SUPFAM
76:CL0049
49:Symbol
2912:LITAF
2817:NCAPH
2807:NCAPG
2780:SMC1B
2775:SMC1A
2730:Other
2721:ATXN7
2704:PTBP1
2687:DDX20
2582:NUP98
2577:NUP93
2572:NUP88
2567:NUP85
2562:NUP62
2557:NUP54
2552:NUP50
2547:NUP43
2542:NUP37
2537:NUP35
2432:ATG12
2422:FAT10
2412:NEDD8
2397:ISG15
2390:Other
2379:PIAS4
2374:PIAS3
2369:PIAS2
2364:PIAS1
2314:(UBL)
2296:BIRC6
2256:FANCL
1928:Other
1917:TRAP1
1886:Hsp90
1812:Hsp70
1701:GroEL
1697:HSP60
1692:Hsp47
1687:Hsp27
478:spf30
463:Fungi
431:KPNB1
389:FUBP1
371:DDX20
359:Bcl-2
272:Tudor
206:genes
104:SCOPe
95:SCOP2
2877:TNP2
2872:TNP1
2849:SMC6
2844:SMC5
2832:SMC4
2827:SMC2
2785:SMC3
2716:TCOF
2692:COIL
2634:AAAS
2447:UBL5
2437:FUB1
2427:ATG8
2407:UFM1
2402:URM1
2352:UBC9
2340:SAE2
2335:SAE1
2301:UFC1
2291:ATG3
2284:CYLD
2279:USP6
2261:UBR1
2251:MDM2
2050:SAE1
2045:NAE1
2040:ATG7
2035:UBA7
2030:UBA6
2025:UBA5
2020:UBA3
2015:UBA2
2010:UBA1
1955:SMN2
1950:SMN1
1585:PMID
1569:Gene
1546:PMID
1505:PMID
1464:PMID
1415:PMID
1374:PMID
1325:PMID
1284:PMID
1243:PMID
1202:PMID
1184:Cell
1158:PMID
1115:PMID
1063:PMID
1014:PMID
965:PMID
912:PMID
862:PMID
813:PMID
772:PMID
729:PMID
677:PMID
628:PMID
587:PMID
538:PMID
395:GAR1
377:DHX9
337:and
236:SMN1
216:gems
202:SMN2
199:and
196:SMN1
155:PDBj
151:PDBe
134:ECOD
124:Pfam
100:1mhn
72:clan
70:Pfam
58:Pfam
36:1g5v
2657:SMN
2442:MUB
2246:CBL
2236:VHL
2229:E3
2058:E2
2003:E1
1872:12A
1803:C19
1798:C14
1793:C13
1788:C11
1783:C10
1738:B11
1577:doi
1573:491
1536:doi
1532:275
1495:doi
1491:277
1454:PMC
1446:doi
1405:doi
1364:PMC
1356:doi
1315:doi
1311:277
1274:doi
1270:277
1233:doi
1229:277
1192:doi
1150:doi
1138:470
1105:doi
1053:PMC
1045:doi
1041:152
1004:PMC
996:doi
992:147
955:PMC
947:doi
902:doi
852:PMC
844:doi
803:doi
764:doi
752:390
721:doi
717:296
667:PMC
659:doi
618:doi
577:PMC
569:doi
530:doi
471:Smn
437:P53
383:FBL
294:of
234:in
187:SMN
181:or
142:PDB
52:SMN
2961::
2503:/
2272::
2216:V2
2211:V1
2201:R2
2195:R1
2190:Q2
2185:Q1
2165:L6
2160:L4
2155:L3
2150:L2
2145:L1
2135:J2
2130:J1
2115:G2
2110:G1
2105:E3
2100:E2
2095:E1
2090:D3
2085:D2
2080:D1
1912:ER
1877:14
1842:4L
1827:1L
1822:1B
1817:1A
1778:C7
1773:C6
1768:C5
1763:C3
1758:C1
1753:B9
1748:B6
1743:B4
1733:B2
1728:B1
1723:A3
1718:A2
1713:A1
1583:.
1571:.
1567:.
1544:.
1530:.
1526:.
1503:.
1489:.
1485:.
1462:.
1452:.
1442:11
1440:.
1436:.
1413:.
1401:11
1399:.
1395:.
1372:.
1362:.
1352:20
1350:.
1346:.
1323:.
1309:.
1305:.
1282:.
1268:.
1264:.
1241:.
1227:.
1223:.
1200:.
1188:90
1186:.
1182:.
1170:^
1156:.
1148:.
1136:.
1113:.
1103:.
1093:11
1091:.
1087:.
1075:^
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