5008:
773:
557:
The approval by the US FDA was based on an international, multicenter, randomized (2:1), phase II study comparing every three-week intravenous infusions of siltuximab and best supportive care to placebo and best supportive care. The trial enrolled 79 participants and randomly allocated 53
1034:
Karkera J, Steiner H, Li W, Skradski V, Moser PL, Riethdorf S, et al. (September 2011). "The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study".
558:
participants to the siltuximab arm plus best supportive care and 26 participants randomized to the placebo arm plus best supportive care. Siltuximab was administered every three weeks as an intravenous infusion at a dose of 11 mg/kg.
188:
3743:
458:
In April 2014, siltuximab was approved for medical use in the United States for the treatment of people with multicentric
Castleman's disease who do not have human immunodeficiency virus (
1192:
Kampan NC, Xiang SD, McNally OM, Stephens AN, Quinn MA, Plebanski M (2018). "Immunotherapeutic
Interleukin-6 or Interleukin-6 Receptor Blockade in Cancer: Challenges and Opportunities".
1108:
van Rhee F, Fayad L, Voorhees P, Furman R, Lonial S, Borghaei H, et al. (August 2010). "Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for
Castleman's disease".
143:
950:
Korneev KV, Atretkhany KN, Drutskaya MS, Grivennikov SI, Kuprash DV, Nedospasov SA (January 2017). "TLR-signaling and proinflammatory cytokines as drivers of tumorigenesis".
617:
404:
2746:
588:, however the efficacy for this cancer is debatable. In addition, siltuximab has been evaluated for multiple myeloma, but there was an insignificant increase in
3736:
1304:
798:
754:
47:
3729:
3155:
2220:
907:
Ferrario A, Merli M, Basilico C, Maffioli M, Passamonti F (March 2017). "Siltuximab and hematologic malignancies. A focus in non
Hodgkin lymphoma".
4941:
4208:
4945:
4931:
4891:
3687:
3356:
4960:
3576:
2739:
1086:
689:
4865:
3213:
3140:
3045:
3813:
3070:
2163:
1533:
425:
609:
1297:
650:
2732:
2572:
173:
113:
5028:
3055:
490:
The common adverse reactions include pruritus, increased weight, rash, hyperuricemia, and upper respiratory tract infection.
455:
The common adverse reactions include pruritus, increased weight, rash, hyperuricemia, and upper respiratory tract infection.
4826:
4805:
3160:
987:"A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer"
3019:
1369:
760:
281:
3704:
1478:
1290:
132:
4998:
2798:
1348:
3263:
2026:
790:
711:
551:
2406:
589:
4784:
4744:
4723:
4667:
4635:
4594:
4552:
4506:
4425:
4399:
4343:
4302:
4276:
4250:
3904:
3692:
3659:
3600:
3551:
3466:
3090:
2401:
714:(2009). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 62".
4359:
766:
4219:
4199:
4178:
4097:
4036:
3980:
3934:
3858:
3763:
3630:
3620:
3590:
3381:
3326:
3253:
3243:
3120:
2206:
1632:
1313:
578:
479:
433:
330:
5033:
3605:
3594:
3556:
3446:
3431:
3361:
3341:
3336:
3115:
2869:
2393:
3869:
4981:
4764:
3752:
3456:
3316:
3085:
3050:
1282:
823:, Kurzrock R (2016). "Siltuximab: a targeted therapy for idiopathic multicentric Castleman disease".
3894:
4755:
4313:
4108:
3884:
3778:
3571:
3541:
3536:
3521:
3351:
3198:
3150:
3110:
2755:
1614:
515:
445:
225:
57:
40:
4625:
4620:
2809:
4605:
4517:
4496:
3945:
3879:
3838:
3782:
3755:
3293:
2844:
2804:
2563:
1664:
1217:
1174:
1060:
932:
4486:
4354:
4261:
4240:
3991:
3960:
3955:
3899:
3818:
2603:
2461:
4532:
3965:
3793:
3788:
2613:
2299:
1740:
4138:
4123:
4087:
4057:
3803:
3180:
2999:
2568:
2558:
1359:
1317:
1268:
1209:
1166:
1125:
1052:
1016:
967:
924:
889:
840:
570:
547:
482:
who are human immunodeficiency virus (HIV) negative and human herpesvirus-8 (HHV-8) negative.
201:
95:
62:
1078:
4976:
2364:
2267:
1930:
1826:
1258:
1248:
1201:
1156:
1117:
1044:
1006:
998:
959:
916:
879:
871:
832:
820:
723:
681:
346:
234:
4452:
4448:
4444:
290:
5012:
4768:
2663:
2548:
574:
985:
Rossi JF, Négrier S, James ND, Kocak I, Hawkins R, Davis H, et al. (October 2010).
4966:
4956:
4951:
4937:
4923:
4913:
4908:
4855:
4837:
4816:
4795:
4774:
4760:
4734:
4678:
4646:
4610:
4573:
4568:
4563:
4527:
4522:
4436:
4415:
4369:
4318:
4287:
4266:
4001:
3970:
3698:
3664:
3331:
2553:
2421:
2069:
1903:
1882:
1878:
1874:
1502:
1339:
1263:
1236:
1011:
986:
884:
859:
585:
437:
1205:
5022:
4708:
4364:
4230:
4189:
4113:
4047:
3996:
3950:
3889:
3774:
3546:
3401:
2954:
2789:
2703:
2633:
2543:
2450:
2236:
1936:
1858:
1810:
1790:
1648:
1564:
1415:
1381:
777:
527:
523:
519:
449:
83:
1221:
1178:
1064:
936:
4882:
4703:
4389:
4384:
4379:
4128:
4067:
4026:
3561:
3526:
3511:
3506:
3501:
3496:
3471:
3426:
3421:
3416:
3411:
3396:
3283:
3258:
3238:
3100:
3065:
3004:
2984:
2794:
2779:
2724:
2713:
2673:
2658:
2653:
2369:
2319:
2314:
2294:
2174:
2169:
2032:
2017:
1965:
1941:
1888:
1765:
1755:
1574:
1491:
1486:
1444:
1397:
1354:
1321:
546:
Siltuximab demonstrated efficacy and safety in people with idiopathic multicentric
531:
156:
151:
3721:
920:
610:"Prescription medicines: registration of new chemical entities in Australia, 2015"
4713:
4693:
4656:
4491:
4481:
4333:
4328:
4163:
4133:
4072:
3914:
3874:
3833:
3828:
3669:
3643:
3638:
3610:
3586:
3581:
3516:
3491:
3481:
3451:
3441:
3406:
3391:
3376:
3366:
3346:
3321:
3306:
3278:
3228:
3223:
3218:
3203:
3193:
3170:
3165:
3135:
3080:
3024:
3014:
2989:
2979:
2974:
2969:
2944:
2919:
2909:
2904:
2899:
2889:
2874:
2859:
2854:
2839:
2834:
2824:
2819:
2814:
2784:
2708:
2648:
2638:
2628:
2528:
2518:
2508:
2503:
2468:
2379:
2374:
2349:
2339:
2329:
2304:
2289:
2284:
2242:
2212:
2198:
2193:
2179:
2122:
2080:
2075:
2061:
2056:
2042:
2022:
1975:
1951:
1909:
1893:
1864:
1848:
1816:
1800:
1795:
1770:
1720:
1710:
1705:
1700:
1689:
1679:
1584:
1496:
1454:
1439:
1433:
1429:
1376:
963:
4698:
4688:
4583:
4476:
4471:
4292:
4143:
4077:
4011:
3924:
3919:
3848:
3615:
3566:
3531:
3461:
3436:
3386:
3371:
3311:
3301:
3248:
3188:
3130:
3125:
3060:
3040:
2994:
2964:
2959:
2949:
2939:
2934:
2924:
2914:
2884:
2879:
2849:
2829:
2698:
2693:
2618:
2608:
2593:
2588:
2583:
2533:
2523:
2513:
2478:
2456:
2442:
2354:
2344:
2334:
2324:
2309:
2252:
2247:
2226:
2141:
2136:
2094:
2088:
1989:
1946:
1842:
1832:
1785:
1750:
1745:
1735:
1730:
1725:
1715:
1674:
1659:
1654:
1638:
1579:
1559:
1508:
1468:
1449:
1391:
1253:
1237:"Novel agents in the treatment of multiple myeloma: a review about the future"
567:
385:
265:
1121:
875:
4168:
4158:
4148:
4021:
3486:
3476:
3268:
3233:
3208:
3145:
3105:
3095:
3075:
3009:
2929:
2894:
2864:
2688:
2683:
2668:
2643:
2598:
2578:
2538:
2473:
2437:
2359:
2155:
2108:
2037:
2003:
1970:
1780:
1760:
1669:
1569:
1409:
475:
1272:
1213:
1170:
1129:
1056:
1020:
1002:
971:
928:
893:
860:"Review of siltuximab in the treatment of multicentric Castleman's disease"
844:
566:
Siltuximab has been investigated for the treatment of neoplastic diseases:
33:
3808:
2764:
2623:
2498:
2187:
1695:
1605:
1541:
1463:
441:
245:
127:
1161:
1144:
254:
4927:
4410:
2116:
1048:
728:
78:
17:
836:
4542:
2431:
2262:
503:
499:
321:
310:
4849:
4845:
4841:
4460:
4456:
4440:
2130:
1983:
554:
are inferior to those obtained in multicentric
Castleman disease.
463:
70:
66:
1145:"First IL-6-blocking drug nears approval for rare blood disorder"
776:
This article incorporates text from this source, which is in the
2102:
2050:
2011:
1997:
1551:
1425:
535:
301:
207:
3725:
2728:
1286:
195:
122:
4917:
1959:
526:
receptors. Siltuximab interferes with IL-6 mediated growth of
459:
502:
activity leading to increased metabolism of drugs that are
182:
522:(IL-6), preventing binding to soluble and membrane bound
432:, is used for the treatment of people with multicentric
411:
4996:
651:"Sylvant- siltuximab injection, powder, for solution"
4901:
4881:
4874:
4825:
4804:
4783:
4743:
4722:
4666:
4634:
4593:
4551:
4505:
4424:
4398:
4342:
4301:
4275:
4249:
4218:
4198:
4177:
4096:
4035:
3979:
3933:
3857:
3762:
3652:
3629:
3292:
3179:
3033:
2772:
2763:
2491:
2419:
2392:
2277:
1920:
1622:
1613:
1604:
1597:
1550:
1532:
1523:
1477:
1408:
1338:
1329:
645:
643:
641:
639:
637:
635:
534:, secretion of vascular endothelial growth factor (
384:
345:
340:
320:
300:
280:
264:
244:
224:
219:
172:
167:
142:
112:
104:
94:
89:
77:
56:
46:
39:
584:Siltuximab has been evaluated in the treatment of
858:Sarosiek S, Shah R, Munshi NC (December 2016).
233:
749:
747:
745:
743:
741:
739:
676:
674:
672:
550:. Treatment results with siltuximab in B-cell
478:for the treatment of people with multicentric
3737:
2740:
1298:
8:
452:. It is an interleukin-6 (IL-6) antagonist.
131:
32:
4878:
3744:
3730:
3722:
2769:
2747:
2733:
2725:
1619:
1610:
1601:
1529:
1335:
1305:
1291:
1283:
1262:
1252:
1160:
1010:
883:
727:
289:
4909:Interleukin 14 (taxilin alpha, HMW-BCGF)
5003:
909:Expert Opinion on Investigational Drugs
601:
253:
4207:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
614:Therapeutic Goods Administration (TGA)
31:
1235:Naymagon L, Abdul-Hay M (June 2016).
329:
7:
1241:Journal of Hematology & Oncology
801:from the original on 8 February 2024
155:
309:
864:Therapeutic Advances in Hematology
620:from the original on 10 April 2023
25:
1206:10.2174/0929867324666170712160621
692:from the original on 24 June 2021
577:, other types of cancer, and for
5006:
1089:from the original on 2 July 2019
771:
363:
357:
4735:Interleukin 27 (interleukin 30)
765:. 23 April 2014. Archived from
375:
369:
351:
1:
921:10.1080/13543784.2017.1288213
428:), sold under the brand name
1370:dihydroorotate dehydrogenase
1143:Williams SC (October 2013).
1110:Journal of Clinical Oncology
761:Food and Drug Administration
538:) and autoimmune phenomena.
4085:Antisense oligonucleotides:
1349:purine synthesis inhibitors
1194:Current Medicinal Chemistry
440:(made from human and mouse
5050:
964:10.1016/j.cyto.2016.01.021
462:) or human herpesvirus-8 (
341:Chemical and physical data
3682:
3264:Mirvetuximab soravtansine
1534:IL-1 receptor antagonists
1254:10.1186/s13045-016-0282-1
991:British Journal of Cancer
712:World Health Organization
686:European Medicines Agency
514:Siltuximab is a chimeric
401:
2407:Anti-lymphocyte globulin
1122:10.1200/JCO.2009.27.2377
876:10.1177/2040620716653745
498:Siltuximab may increase
4775:Interleukin-29 (IFN-λ1)
3920:Daclizumab (dacliximab)
3905:Tucotuzumab celmoleukin
3660:Depatuxizumab mafodotin
3601:Tucotuzumab celmoleukin
3552:Rovalpituzumab tesirine
3467:Lorvotuzumab mertansine
3357:Clivatuzumab tetraxetan
2402:Anti-thymocyte globulin
1314:Immunosuppressive drugs
4756:Interferon λ4 (IFN-λ4)
3849:Rilonacept (IL-1 Trap)
3621:Vorsetuzumab mafodotin
3577:Tacatuzumab tetraxetan
3382:Denintuzumab mafodotin
3327:Bivatuzumab mertansine
3254:Loncastuximab tesirine
3244:Indatuximab ravtansine
3121:Naptumomab estafenatox
2207:Interleukin-6 receptor
1633:Complement component 5
1003:10.1038/sj.bjc.6605872
791:"Sylvant (siltuximab)"
552:non-Hodgkin's lymphoma
5029:Monoclonal antibodies
4679:Interleukin 23 (SGRF)
4360:Cintredekin besudotox
4288:Interleukin 11 (AGIF)
4267:Interleukin 10 (CSIF)
3606:Vandortuzumab vedotin
3557:Sacituzumab govitecan
3447:Inotuzumab ozogamicin
3432:Gemtuzumab ozogamicin
3362:Cofetuzumab pelidotin
3342:Cantuzumab ravtansine
3337:Cantuzumab mertansine
3156:Nofetumomab merpentan
3116:Moxetumomab pasudotox
2870:Glembatumumab vedotin
2756:Monoclonal antibodies
797:. 28 September 2015.
3753:Interleukin receptor
3653:Chimeric + humanized
3457:Lifastuzumab vedotin
3317:Belantamab mafodotin
3086:Ibritumomab tiuxetan
3051:Anatumomab mafenatox
716:WHO Drug Information
688:. 30 November 2007.
3885:Denileukin diftitox
3572:Sofituzumab vedotin
3542:Polatuzumab vedotin
3537:Pinatuzumab vedotin
3522:Oportuzumab monatox
3352:Citatuzumab bogatox
3214:Derlotuximab biotin
3199:Brentuximab vedotin
3151:Taplitumomab paptox
3141:Satumomab pendetide
3111:Nacolomab tafenatox
3046:Altumomab pentetate
1162:10.1038/nm1013-1193
579:Castleman's disease
516:monoclonal antibody
510:Mechanism of action
480:Castleman's disease
446:monoclonal antibody
434:Castleman's disease
191:(Prescription only)
41:Monoclonal antibody
36:
27:Pharmaceutical drug
4457:E (interleukin 25)
3709:Never to phase III
3071:Capromab pendetide
2845:Enfortumab vedotin
2564:Diroximel fumarate
2237:IL-2 receptor/CD25
1665:Certolizumab pegol
1318:Immunosuppressants
1083:ClinicalTrials.gov
1049:10.1002/pros.21362
795:accessdata.fda.gov
657:. 21 February 2024
4994:
4993:
4990:
4989:
4959:(signals through
4940:(signals through
4926:(signals through
4916:(signals through
4540:Binding proteins:
3870:Adargileukin alfa
3719:
3718:
3678:
3677:
3000:Tisotumab vedotin
2722:
2721:
2569:Efgartigimod alfa
2559:Dimethyl fumarate
2487:
2486:
2415:
2414:
2388:
2387:
1593:
1592:
1519:
1518:
1360:Mycophenolic acid
1200:(36): 4785–4806.
837:10.2217/imt.15.95
571:renal cell cancer
548:Castleman disease
494:Drug interactions
419:
418:
211:
199:
186:
125:
16:(Redirected from
5041:
5011:
5010:
5009:
5002:
4982:Efineptakin alfa
4977:Efavaleukin alfa
4879:
3846:Decoy receptors:
3746:
3739:
3732:
3723:
3631:Rat/mouse hybrid
2770:
2749:
2742:
2735:
2726:
2365:Telimomab aritox
2268:Zolimomab aritox
2089:CD62L/L-selectin
1827:Immunoglobulin E
1620:
1611:
1602:
1530:
1336:
1307:
1300:
1293:
1284:
1277:
1276:
1266:
1256:
1232:
1226:
1225:
1189:
1183:
1182:
1164:
1140:
1134:
1133:
1105:
1099:
1098:
1096:
1094:
1075:
1069:
1068:
1031:
1025:
1024:
1014:
982:
976:
975:
947:
941:
940:
904:
898:
897:
887:
855:
849:
848:
817:
811:
810:
808:
806:
787:
781:
775:
774:
770:
751:
734:
733:
731:
708:
702:
701:
699:
697:
678:
667:
666:
664:
662:
647:
630:
629:
627:
625:
616:. 21 June 2022.
606:
415:
414:
407:
396:
394:
377:
371:
365:
359:
353:
333:
313:
293:
257:
237:
209:
206:
197:
194:
184:
181:
159:
135:
124:
121:
37:
35:
21:
5049:
5048:
5044:
5043:
5042:
5040:
5039:
5038:
5019:
5018:
5017:
5007:
5005:
4997:
4995:
4986:
4897:
4870:
4821:
4800:
4779:
4739:
4718:
4662:
4659:(against IL-22)
4630:
4589:
4586:(against IL-20)
4547:
4501:
4420:
4394:
4338:
4297:
4271:
4245:
4214:
4194:
4173:
4092:
4031:
3975:
3929:
3853:
3758:
3750:
3720:
3715:
3714:
3699:Clinical trials
3674:
3648:
3625:
3288:
3175:
3029:
2759:
2753:
2723:
2718:
2664:Rozanolixizumab
2549:Deucravacitinib
2483:
2411:
2384:
2273:
1922:
1916:
1624:
1589:
1546:
1525:
1515:
1473:
1413:
1404:
1340:Antimetabolites
1331:
1325:
1311:
1281:
1280:
1234:
1233:
1229:
1191:
1190:
1186:
1149:Nature Medicine
1142:
1141:
1137:
1107:
1106:
1102:
1092:
1090:
1077:
1076:
1072:
1043:(13): 1455–65.
1033:
1032:
1028:
984:
983:
979:
949:
948:
944:
906:
905:
901:
857:
856:
852:
819:
818:
814:
804:
802:
789:
788:
784:
772:
769:on 3 June 2014.
753:
752:
737:
710:
709:
705:
695:
693:
680:
679:
670:
660:
658:
649:
648:
633:
623:
621:
608:
607:
603:
598:
575:prostate cancer
564:
544:
512:
496:
488:
472:
410:
408:
405:(what is this?)
402:
392:
390:
380:
374:
368:
362:
356:
336:
316:
296:
276:
260:
240:
215:
163:
138:
28:
23:
22:
15:
12:
11:
5:
5047:
5045:
5037:
5036:
5031:
5021:
5020:
5016:
5015:
4992:
4991:
4988:
4987:
4985:
4984:
4979:
4970:
4969:
4967:Interleukin 35
4964:
4957:Interleukin 34
4954:
4952:Interleukin 32
4949:
4938:Interleukin 26
4935:
4924:Interleukin 24
4921:
4914:Interleukin 16
4911:
4905:
4903:
4899:
4898:
4896:
4895:
4887:
4885:
4876:
4872:
4871:
4869:
4868:
4859:
4858:
4856:Interleukin 38
4853:
4838:Interleukin 36
4831:
4829:
4823:
4822:
4820:
4819:
4817:Interleukin 33
4810:
4808:
4802:
4801:
4799:
4798:
4796:Interleukin 31
4789:
4787:
4781:
4780:
4778:
4777:
4772:
4761:Interleukin 28
4758:
4749:
4747:
4741:
4740:
4738:
4737:
4728:
4726:
4720:
4719:
4717:
4716:
4711:
4706:
4701:
4696:
4691:
4682:
4681:
4672:
4670:
4664:
4663:
4661:
4660:
4650:
4649:
4647:Interleukin 22
4640:
4638:
4632:
4631:
4629:
4628:
4623:
4614:
4613:
4611:Interleukin 21
4608:
4599:
4597:
4591:
4590:
4588:
4587:
4577:
4576:
4574:Interleukin 24
4571:
4569:Interleukin 20
4566:
4564:Interleukin 19
4557:
4555:
4549:
4548:
4546:
4545:
4536:
4535:
4530:
4528:Interleukin 37
4525:
4523:Interleukin 18
4520:
4511:
4509:
4503:
4502:
4500:
4499:
4494:
4489:
4484:
4479:
4474:
4465:
4464:
4437:Interleukin 17
4430:
4428:
4422:
4421:
4419:
4418:
4416:Interleukin 15
4413:
4404:
4402:
4396:
4395:
4393:
4392:
4387:
4382:
4373:
4372:
4370:Interleukin 13
4367:
4362:
4357:
4348:
4346:
4340:
4339:
4337:
4336:
4331:
4322:
4321:
4319:Interleukin 12
4316:
4307:
4305:
4299:
4298:
4296:
4295:
4290:
4281:
4279:
4273:
4272:
4270:
4269:
4264:
4255:
4253:
4247:
4246:
4244:
4243:
4234:
4233:
4224:
4222:
4216:
4215:
4213:
4212:
4204:
4202:
4196:
4195:
4193:
4192:
4183:
4181:
4175:
4174:
4172:
4171:
4166:
4161:
4156:
4151:
4146:
4141:
4136:
4131:
4126:
4117:
4116:
4111:
4102:
4100:
4094:
4093:
4091:
4090:
4081:
4080:
4075:
4070:
4061:
4060:
4051:
4050:
4041:
4039:
4033:
4032:
4030:
4029:
4024:
4015:
4014:
4005:
4004:
4002:Interleukin 13
3999:
3994:
3985:
3983:
3977:
3976:
3974:
3973:
3971:Promegapoietin
3968:
3963:
3958:
3953:
3948:
3939:
3937:
3931:
3930:
3928:
3927:
3922:
3917:
3908:
3907:
3902:
3897:
3895:Pegaldesleukin
3892:
3887:
3882:
3877:
3872:
3863:
3861:
3855:
3854:
3852:
3851:
3842:
3841:
3836:
3831:
3822:
3821:
3816:
3811:
3806:
3797:
3796:
3791:
3786:
3768:
3766:
3760:
3759:
3751:
3749:
3748:
3741:
3734:
3726:
3717:
3716:
3713:
3712:
3711:
3710:
3707:
3696:
3690:
3684:
3683:
3680:
3679:
3676:
3675:
3673:
3672:
3667:
3665:Duvortuxizumab
3662:
3656:
3654:
3650:
3649:
3647:
3646:
3641:
3635:
3633:
3627:
3626:
3624:
3623:
3618:
3613:
3608:
3603:
3598:
3584:
3579:
3574:
3569:
3564:
3559:
3554:
3549:
3544:
3539:
3534:
3529:
3524:
3519:
3514:
3509:
3504:
3499:
3494:
3489:
3484:
3479:
3474:
3469:
3464:
3459:
3454:
3449:
3444:
3439:
3434:
3429:
3424:
3419:
3414:
3409:
3404:
3399:
3394:
3389:
3384:
3379:
3374:
3369:
3364:
3359:
3354:
3349:
3344:
3339:
3334:
3332:Brontictuzumab
3329:
3324:
3319:
3314:
3309:
3304:
3298:
3296:
3290:
3289:
3287:
3286:
3281:
3276:
3271:
3266:
3261:
3256:
3251:
3246:
3241:
3236:
3231:
3226:
3221:
3216:
3211:
3206:
3201:
3196:
3191:
3185:
3183:
3177:
3176:
3174:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3037:
3035:
3031:
3030:
3028:
3027:
3022:
3017:
3012:
3007:
3002:
2997:
2992:
2987:
2982:
2977:
2972:
2967:
2962:
2957:
2952:
2947:
2942:
2937:
2932:
2927:
2922:
2917:
2912:
2907:
2902:
2897:
2892:
2887:
2882:
2877:
2872:
2867:
2862:
2857:
2852:
2847:
2842:
2837:
2832:
2827:
2822:
2817:
2812:
2807:
2802:
2799:+hyaluronidase
2792:
2787:
2782:
2776:
2774:
2767:
2761:
2760:
2754:
2752:
2751:
2744:
2737:
2729:
2720:
2719:
2717:
2716:
2711:
2706:
2701:
2696:
2691:
2686:
2681:
2676:
2671:
2666:
2661:
2656:
2651:
2646:
2641:
2636:
2631:
2626:
2621:
2616:
2611:
2606:
2601:
2596:
2591:
2586:
2581:
2576:
2573:+hyaluronidase
2566:
2561:
2556:
2554:Deuruxolitinib
2551:
2546:
2541:
2536:
2531:
2526:
2521:
2516:
2511:
2506:
2501:
2495:
2493:
2489:
2488:
2485:
2484:
2482:
2481:
2476:
2471:
2466:
2465:
2464:
2459:
2447:
2446:
2445:
2440:
2427:
2425:
2417:
2416:
2413:
2412:
2410:
2409:
2404:
2398:
2396:
2390:
2389:
2386:
2385:
2383:
2382:
2377:
2372:
2367:
2362:
2357:
2352:
2347:
2342:
2337:
2332:
2327:
2322:
2317:
2312:
2307:
2302:
2297:
2292:
2287:
2281:
2279:
2275:
2274:
2272:
2271:
2258:
2257:
2256:
2255:
2250:
2245:
2232:
2231:
2230:
2229:
2217:
2216:
2215:
2203:
2202:
2201:
2196:
2184:
2183:
2182:
2177:
2172:
2160:
2159:
2158:
2147:
2146:
2145:
2144:
2139:
2127:
2126:
2125:
2113:
2112:
2111:
2099:
2098:
2097:
2085:
2084:
2083:
2078:
2066:
2065:
2064:
2059:
2047:
2046:
2045:
2040:
2035:
2030:
2027:+hyaluronidase
2020:
2008:
2007:
2006:
1994:
1993:
1992:
1980:
1979:
1978:
1973:
1968:
1956:
1955:
1954:
1949:
1944:
1939:
1926:
1924:
1918:
1917:
1915:
1914:
1913:
1912:
1899:
1898:
1897:
1896:
1891:
1870:
1869:
1868:
1867:
1854:
1853:
1852:
1851:
1838:
1837:
1836:
1835:
1822:
1821:
1820:
1819:
1806:
1805:
1804:
1803:
1798:
1793:
1788:
1783:
1778:
1773:
1768:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1728:
1723:
1718:
1713:
1708:
1703:
1698:
1685:
1684:
1683:
1682:
1677:
1672:
1667:
1662:
1657:
1644:
1643:
1642:
1641:
1628:
1626:
1617:
1608:
1599:
1595:
1594:
1591:
1590:
1588:
1587:
1582:
1577:
1572:
1567:
1562:
1556:
1554:
1548:
1547:
1545:
1544:
1538:
1536:
1527:
1521:
1520:
1517:
1516:
1514:
1513:
1512:
1511:
1503:PDE4 inhibitor
1499:
1494:
1489:
1483:
1481:
1475:
1474:
1472:
1471:
1466:
1460:
1459:
1458:
1457:
1452:
1447:
1442:
1421:
1419:
1406:
1405:
1403:
1402:
1401:
1400:
1387:
1386:
1385:
1384:
1379:
1365:
1364:
1363:
1362:
1357:
1344:
1342:
1333:
1327:
1326:
1312:
1310:
1309:
1302:
1295:
1287:
1279:
1278:
1227:
1184:
1135:
1116:(23): 3701–8.
1100:
1070:
1026:
997:(8): 1154–62.
977:
942:
915:(3): 367–373.
899:
870:(6): 360–366.
850:
812:
782:
735:
703:
682:"Sylvant EPAR"
668:
631:
600:
599:
597:
594:
590:response rates
586:ovarian cancer
563:
560:
543:
540:
518:that binds to
511:
508:
495:
492:
487:
484:
474:Siltuximab is
471:
468:
448:that binds to
417:
416:
399:
398:
388:
382:
381:
378:
372:
366:
360:
354:
349:
343:
342:
338:
337:
335:
334:
326:
324:
318:
317:
315:
314:
306:
304:
298:
297:
295:
294:
286:
284:
278:
277:
275:
274:
270:
268:
262:
261:
259:
258:
250:
248:
242:
241:
239:
238:
230:
228:
222:
221:
217:
216:
214:
213:
204:
192:
178:
176:
170:
169:
165:
164:
162:
161:
148:
146:
140:
139:
137:
136:
118:
116:
110:
109:
106:
102:
101:
98:
92:
91:
87:
86:
81:
75:
74:
60:
54:
53:
52:Whole antibody
50:
44:
43:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5046:
5035:
5032:
5030:
5027:
5026:
5024:
5014:
5004:
5000:
4983:
4980:
4978:
4975:
4972:
4971:
4968:
4965:
4962:
4958:
4955:
4953:
4950:
4947:
4943:
4939:
4936:
4933:
4929:
4925:
4922:
4919:
4915:
4912:
4910:
4907:
4906:
4904:
4900:
4893:
4889:
4888:
4886:
4884:
4880:
4877:
4873:
4867:
4864:
4861:
4860:
4857:
4854:
4851:
4847:
4843:
4839:
4836:
4833:
4832:
4830:
4828:
4824:
4818:
4815:
4812:
4811:
4809:
4807:
4803:
4797:
4794:
4791:
4790:
4788:
4786:
4782:
4776:
4773:
4770:
4766:
4762:
4759:
4757:
4754:
4751:
4750:
4748:
4746:
4742:
4736:
4733:
4730:
4729:
4727:
4725:
4721:
4715:
4712:
4710:
4709:Tildrakizumab
4707:
4705:
4702:
4700:
4697:
4695:
4692:
4690:
4687:
4684:
4683:
4680:
4677:
4674:
4673:
4671:
4669:
4665:
4658:
4655:
4652:
4651:
4648:
4645:
4642:
4641:
4639:
4637:
4633:
4627:
4624:
4622:
4619:
4616:
4615:
4612:
4609:
4607:
4604:
4601:
4600:
4598:
4596:
4592:
4585:
4582:
4579:
4578:
4575:
4572:
4570:
4567:
4565:
4562:
4559:
4558:
4556:
4554:
4550:
4544:
4541:
4538:
4537:
4534:
4531:
4529:
4526:
4524:
4521:
4519:
4516:
4513:
4512:
4510:
4508:
4504:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4473:
4470:
4467:
4466:
4462:
4458:
4454:
4450:
4446:
4442:
4438:
4435:
4432:
4431:
4429:
4427:
4423:
4417:
4414:
4412:
4409:
4406:
4405:
4403:
4401:
4397:
4391:
4388:
4386:
4383:
4381:
4378:
4375:
4374:
4371:
4368:
4366:
4365:Interleukin 4
4363:
4361:
4358:
4356:
4353:
4350:
4349:
4347:
4345:
4341:
4335:
4332:
4330:
4327:
4324:
4323:
4320:
4317:
4315:
4314:Edodekin alfa
4312:
4309:
4308:
4306:
4304:
4300:
4294:
4291:
4289:
4286:
4283:
4282:
4280:
4278:
4274:
4268:
4265:
4263:
4260:
4257:
4256:
4254:
4252:
4248:
4242:
4239:
4236:
4235:
4232:
4231:Interleukin 9
4229:
4226:
4225:
4223:
4221:
4217:
4210:
4206:
4205:
4203:
4201:
4197:
4191:
4190:Interleukin 7
4188:
4185:
4184:
4182:
4180:
4176:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4119:
4118:
4115:
4114:Interleukin 6
4112:
4110:
4109:Atexakin alfa
4107:
4104:
4103:
4101:
4099:
4095:
4089:
4086:
4083:
4082:
4079:
4076:
4074:
4071:
4069:
4066:
4063:
4062:
4059:
4056:
4053:
4052:
4049:
4048:Interleukin 5
4046:
4043:
4042:
4040:
4038:
4034:
4028:
4025:
4023:
4020:
4017:
4016:
4013:
4010:
4007:
4006:
4003:
4000:
3998:
3997:Interleukin 4
3995:
3993:
3990:
3987:
3986:
3984:
3982:
3978:
3972:
3969:
3967:
3964:
3962:
3959:
3957:
3954:
3952:
3951:Interleukin 3
3949:
3947:
3944:
3941:
3940:
3938:
3936:
3932:
3926:
3923:
3921:
3918:
3916:
3913:
3910:
3909:
3906:
3903:
3901:
3898:
3896:
3893:
3891:
3890:Interleukin 2
3888:
3886:
3883:
3881:
3878:
3876:
3873:
3871:
3868:
3865:
3864:
3862:
3860:
3856:
3850:
3847:
3844:
3843:
3840:
3837:
3835:
3832:
3830:
3827:
3824:
3823:
3820:
3817:
3815:
3812:
3810:
3807:
3805:
3802:
3799:
3798:
3795:
3792:
3790:
3787:
3784:
3780:
3776:
3775:Interleukin 1
3773:
3770:
3769:
3767:
3765:
3761:
3757:
3754:
3747:
3742:
3740:
3735:
3733:
3728:
3727:
3724:
3708:
3706:
3703:
3702:
3700:
3697:
3694:
3691:
3689:
3686:
3685:
3681:
3671:
3668:
3666:
3663:
3661:
3658:
3657:
3655:
3651:
3645:
3642:
3640:
3637:
3636:
3634:
3632:
3628:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3596:
3592:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3558:
3555:
3553:
3550:
3548:
3547:Rosmantuzumab
3545:
3543:
3540:
3538:
3535:
3533:
3530:
3528:
3525:
3523:
3520:
3518:
3515:
3513:
3510:
3508:
3505:
3503:
3500:
3498:
3495:
3493:
3490:
3488:
3485:
3483:
3480:
3478:
3475:
3473:
3470:
3468:
3465:
3463:
3460:
3458:
3455:
3453:
3450:
3448:
3445:
3443:
3440:
3438:
3435:
3433:
3430:
3428:
3425:
3423:
3420:
3418:
3415:
3413:
3410:
3408:
3405:
3403:
3402:Enoblituzumab
3400:
3398:
3395:
3393:
3390:
3388:
3385:
3383:
3380:
3378:
3375:
3373:
3370:
3368:
3365:
3363:
3360:
3358:
3355:
3353:
3350:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3328:
3325:
3323:
3320:
3318:
3315:
3313:
3310:
3308:
3305:
3303:
3300:
3299:
3297:
3295:
3291:
3285:
3282:
3280:
3277:
3275:
3272:
3270:
3267:
3265:
3262:
3260:
3257:
3255:
3252:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3230:
3227:
3225:
3222:
3220:
3217:
3215:
3212:
3210:
3207:
3205:
3202:
3200:
3197:
3195:
3192:
3190:
3187:
3186:
3184:
3182:
3178:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3038:
3036:
3032:
3026:
3023:
3021:
3018:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2996:
2993:
2991:
2988:
2986:
2983:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2956:
2955:Pembrolizumab
2953:
2951:
2948:
2946:
2943:
2941:
2938:
2936:
2933:
2931:
2928:
2926:
2923:
2921:
2918:
2916:
2913:
2911:
2908:
2906:
2903:
2901:
2898:
2896:
2893:
2891:
2888:
2886:
2883:
2881:
2878:
2876:
2873:
2871:
2868:
2866:
2863:
2861:
2858:
2856:
2853:
2851:
2848:
2846:
2843:
2841:
2838:
2836:
2833:
2831:
2828:
2826:
2823:
2821:
2818:
2816:
2813:
2811:
2808:
2806:
2803:
2800:
2796:
2793:
2791:
2790:Ascrinvacumab
2788:
2786:
2783:
2781:
2778:
2777:
2775:
2771:
2768:
2766:
2762:
2757:
2750:
2745:
2743:
2738:
2736:
2731:
2730:
2727:
2715:
2712:
2710:
2707:
2705:
2704:Tildrakizumab
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2675:
2672:
2670:
2667:
2665:
2662:
2660:
2657:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2635:
2634:Pegcetacoplan
2632:
2630:
2627:
2625:
2622:
2620:
2617:
2615:
2612:
2610:
2607:
2605:
2602:
2600:
2597:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2574:
2570:
2567:
2565:
2562:
2560:
2557:
2555:
2552:
2550:
2547:
2545:
2544:Darvadstrocel
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2517:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2496:
2494:
2490:
2480:
2477:
2475:
2472:
2470:
2467:
2463:
2460:
2458:
2455:
2454:
2453:
2452:
2451:TNF inhibitor
2448:
2444:
2441:
2439:
2436:
2435:
2434:
2433:
2429:
2428:
2426:
2423:
2418:
2408:
2405:
2403:
2400:
2399:
2397:
2395:
2391:
2381:
2378:
2376:
2373:
2371:
2368:
2366:
2363:
2361:
2358:
2356:
2353:
2351:
2348:
2346:
2343:
2341:
2338:
2336:
2333:
2331:
2328:
2326:
2323:
2321:
2318:
2316:
2313:
2311:
2308:
2306:
2303:
2301:
2298:
2296:
2293:
2291:
2288:
2286:
2283:
2282:
2280:
2276:
2269:
2265:
2264:
2260:
2259:
2254:
2251:
2249:
2246:
2244:
2241:
2240:
2239:
2238:
2234:
2233:
2228:
2225:
2224:
2223:
2222:
2218:
2214:
2211:
2210:
2209:
2208:
2204:
2200:
2197:
2195:
2192:
2191:
2190:
2189:
2185:
2181:
2178:
2176:
2173:
2171:
2168:
2167:
2166:
2165:
2161:
2157:
2154:
2153:
2152:
2149:
2148:
2143:
2140:
2138:
2135:
2134:
2133:
2132:
2128:
2124:
2121:
2120:
2119:
2118:
2117:CD147/Basigin
2114:
2110:
2107:
2106:
2105:
2104:
2100:
2096:
2093:
2092:
2091:
2090:
2086:
2082:
2079:
2077:
2074:
2073:
2072:
2071:
2067:
2063:
2060:
2058:
2055:
2054:
2053:
2052:
2048:
2044:
2041:
2039:
2036:
2034:
2031:
2028:
2024:
2021:
2019:
2016:
2015:
2014:
2013:
2009:
2005:
2002:
2001:
2000:
1999:
1995:
1991:
1988:
1987:
1986:
1985:
1981:
1977:
1974:
1972:
1969:
1967:
1964:
1963:
1962:
1961:
1957:
1953:
1950:
1948:
1945:
1943:
1940:
1938:
1937:Muromonab-CD3
1935:
1934:
1933:
1932:
1928:
1927:
1925:
1919:
1911:
1908:
1907:
1906:
1905:
1901:
1900:
1895:
1892:
1890:
1887:
1886:
1885:
1884:
1880:
1876:
1872:
1871:
1866:
1863:
1862:
1861:
1860:
1856:
1855:
1850:
1847:
1846:
1845:
1844:
1840:
1839:
1834:
1831:
1830:
1829:
1828:
1824:
1823:
1818:
1815:
1814:
1813:
1812:
1811:Interleukin 5
1808:
1807:
1802:
1799:
1797:
1794:
1792:
1791:Tildrakizumab
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1757:
1754:
1752:
1749:
1747:
1744:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1702:
1699:
1697:
1694:
1693:
1692:
1691:
1687:
1686:
1681:
1678:
1676:
1673:
1671:
1668:
1666:
1663:
1661:
1658:
1656:
1653:
1652:
1651:
1650:
1646:
1645:
1640:
1637:
1636:
1635:
1634:
1630:
1629:
1627:
1625:(noncellular)
1621:
1618:
1616:
1612:
1609:
1607:
1603:
1600:
1598:Extracellular
1596:
1586:
1583:
1581:
1578:
1576:
1573:
1571:
1568:
1566:
1565:Ridaforolimus
1563:
1561:
1558:
1557:
1555:
1553:
1549:
1543:
1540:
1539:
1537:
1535:
1531:
1528:
1524:Intracellular
1522:
1510:
1507:
1506:
1505:
1504:
1500:
1498:
1495:
1493:
1490:
1488:
1485:
1484:
1482:
1480:
1476:
1470:
1467:
1465:
1462:
1461:
1456:
1453:
1451:
1448:
1446:
1443:
1441:
1438:
1437:
1436:
1435:
1431:
1427:
1423:
1422:
1420:
1417:
1411:
1407:
1399:
1396:
1395:
1394:
1393:
1389:
1388:
1383:
1382:Teriflunomide
1380:
1378:
1375:
1374:
1372:
1371:
1367:
1366:
1361:
1358:
1356:
1353:
1352:
1351:
1350:
1346:
1345:
1343:
1341:
1337:
1334:
1330:Intracellular
1328:
1323:
1319:
1315:
1308:
1303:
1301:
1296:
1294:
1289:
1288:
1285:
1274:
1270:
1265:
1260:
1255:
1250:
1246:
1242:
1238:
1231:
1228:
1223:
1219:
1215:
1211:
1207:
1203:
1199:
1195:
1188:
1185:
1180:
1176:
1172:
1168:
1163:
1158:
1154:
1150:
1146:
1139:
1136:
1131:
1127:
1123:
1119:
1115:
1111:
1104:
1101:
1088:
1084:
1080:
1074:
1071:
1066:
1062:
1058:
1054:
1050:
1046:
1042:
1038:
1030:
1027:
1022:
1018:
1013:
1008:
1004:
1000:
996:
992:
988:
981:
978:
973:
969:
965:
961:
957:
953:
946:
943:
938:
934:
930:
926:
922:
918:
914:
910:
903:
900:
895:
891:
886:
881:
877:
873:
869:
865:
861:
854:
851:
846:
842:
838:
834:
830:
826:
825:Immunotherapy
822:
821:Fajgenbaum DC
816:
813:
800:
796:
792:
786:
783:
779:
778:public domain
768:
764:
762:
756:
750:
748:
746:
744:
742:
740:
736:
730:
725:
721:
717:
713:
707:
704:
691:
687:
683:
677:
675:
673:
669:
656:
652:
646:
644:
642:
640:
638:
636:
632:
619:
615:
611:
605:
602:
595:
593:
591:
587:
582:
580:
576:
572:
569:
561:
559:
555:
553:
549:
541:
539:
537:
533:
529:
528:B-lymphocytes
525:
524:interleukin-6
521:
520:interleukin-6
517:
509:
507:
505:
501:
493:
491:
485:
483:
481:
477:
469:
467:
465:
461:
456:
453:
451:
450:interleukin-6
447:
443:
439:
435:
431:
427:
423:
413:
406:
400:
389:
387:
383:
350:
348:
344:
339:
332:
331:ChEMBL1743070
328:
327:
325:
323:
319:
312:
308:
307:
305:
303:
299:
292:
288:
287:
285:
283:
279:
272:
271:
269:
267:
263:
256:
252:
251:
249:
247:
243:
236:
232:
231:
229:
227:
223:
218:
212: Rx-only
205:
203:
193:
190:
180:
179:
177:
175:
171:
166:
158:
153:
150:
149:
147:
145:
141:
134:
129:
120:
119:
117:
115:
111:
107:
103:
99:
97:
93:
90:Clinical data
88:
85:
82:
80:
76:
72:
68:
64:
61:
59:
55:
51:
49:
45:
42:
38:
30:
19:
5034:Orphan drugs
4973:
4961:M-CSFR/CSF1R
4948:heterodimer)
4934:heterodimer)
4863:Antagonists:
4862:
4834:
4813:
4792:
4752:
4731:
4704:Risankizumab
4685:
4675:
4653:
4643:
4626:NNC0114-0006
4621:NNC0114-0005
4617:
4602:
4580:
4560:
4539:
4514:
4468:
4433:
4407:
4390:Tralokinumab
4385:Lebrikizumab
4380:Anrukinzumab
4376:
4351:
4325:
4310:
4284:
4258:
4237:
4227:
4186:
4153:
4129:Clazakizumab
4120:
4105:
4084:
4068:Benralizumab
4064:
4055:Antagonists:
4054:
4044:
4027:Pascolizumab
4018:
4009:Antagonists:
4008:
3988:
3942:
3911:
3866:
3845:
3825:
3801:Antagonists:
3800:
3771:
3562:Sibrotuzumab
3527:Parsatuzumab
3512:Otlertuzumab
3507:Odronextamab
3502:Ocaratuzumab
3497:Obinutuzumab
3472:Lumretuzumab
3427:Flotetuzumab
3422:Ficlatuzumab
3417:Farletuzumab
3412:Etaracizumab
3397:Emibetuzumab
3284:Zolbetuximab
3273:
3259:Margetuximab
3239:Girentuximab
3101:Minretumomab
3066:Blinatumomab
3005:Teprotumumab
2985:Seribantumab
2810:Botensilimab
2795:Atezolizumab
2780:Adecatumumab
2714:Upadacitinib
2678:
2674:Satralizumab
2659:Ritlecitinib
2654:Risankizumab
2449:
2430:
2370:Teprotumumab
2320:Inebilizumab
2315:Fontolizumab
2295:Atorolimumab
2263:T-lymphocyte
2261:
2235:
2219:
2205:
2186:
2175:Lerdelimumab
2170:Bertilimumab
2162:
2150:
2129:
2115:
2101:
2087:
2068:
2049:
2033:Pascolizumab
2018:Obinutuzumab
2010:
1996:
1982:
1966:Clenoliximab
1958:
1942:Otelixizumab
1929:
1902:
1889:Lebrikizumab
1873:
1857:
1841:
1825:
1809:
1775:
1766:Satralizumab
1756:Risankizumab
1688:
1647:
1631:
1623:Serum target
1575:Temsirolimus
1501:
1492:Pomalidomide
1487:Lenalidomide
1445:Pimecrolimus
1424:
1398:Methotrexate
1390:
1368:
1355:Azathioprine
1347:
1332:(initiation)
1244:
1240:
1230:
1197:
1193:
1187:
1155:(10): 1193.
1152:
1148:
1138:
1113:
1109:
1103:
1091:. Retrieved
1082:
1079:"Siltuximab"
1073:
1040:
1037:The Prostate
1036:
1029:
994:
990:
980:
955:
951:
945:
912:
908:
902:
867:
863:
853:
831:(1): 17–26.
828:
824:
815:
803:. Retrieved
794:
785:
767:the original
758:
755:"Siltuximab"
719:
715:
706:
694:. Retrieved
685:
659:. Retrieved
654:
622:. Retrieved
613:
604:
583:
565:
556:
545:
532:plasma cells
513:
506:substrates.
497:
489:
486:Side effects
473:
470:Medical uses
457:
454:
429:
421:
420:
409:
403:
174:Legal status
168:Legal status
114:License data
29:
4714:Ustekinumab
4694:Briakinumab
4686:Antibodies:
4657:Fezakinumab
4654:Antibodies:
4618:Antibodies:
4606:Denenicokin
4581:Antibodies:
4518:Iboctadekin
4497:Vunakizumab
4492:Secukinumab
4482:Perakizumab
4469:Antibodies:
4377:Antibodies:
4334:Ustekinumab
4329:Briakinumab
4326:Antibodies:
4238:Antibodies:
4164:Tocilizumab
4134:Elsilimomab
4121:Antibodies:
4073:Mepolizumab
4065:Antibodies:
4019:Antibodies:
3946:Daniplestim
3915:Basiliximab
3912:Antibodies:
3880:Celmoleukin
3875:Aldesleukin
3839:Lutikizumab
3834:Gevokizumab
3829:Canakinumab
3826:Antibodies:
3695:from market
3670:Ontuxizumab
3644:Ertumaxomab
3639:Catumaxomab
3611:Vanucizumab
3591:+deruxtecan
3587:Trastuzumab
3582:Tigatuzumab
3517:Onartuzumab
3492:Nimotuzumab
3482:Milatuzumab
3452:Labetuzumab
3442:Imgatuzumab
3407:Epcoritamab
3392:Emactuzumab
3377:Dalotuzumab
3367:Dacetuzumab
3347:Cirmtuzumab
3322:Bevacizumab
3307:Alemtuzumab
3279:Ublituximab
3229:Ensituximab
3224:Ecromeximab
3219:Dinutuximab
3204:Carotuximab
3194:Bavituximab
3171:Tositumomab
3166:Tenatumomab
3136:Racotumomab
3081:Edrecolomab
3056:Arcitumomab
3025:Zalutumumab
3015:Vantictumab
2990:Sugemalimab
2980:Robatumumab
2975:Rilotumumab
2970:Ramucirumab
2945:Panitumumab
2920:Necitumumab
2910:Mapatumumab
2905:Lucatumumab
2900:Lexatumumab
2890:Istiratumab
2875:Intetumumab
2860:Flanvotumab
2855:Figitumumab
2840:Dusigitumab
2835:Duligotumab
2825:Daratumumab
2820:Conatumumab
2815:Cixutumumab
2805:Balstilimab
2785:Amivantamab
2709:Tofacitinib
2649:Ravulizumab
2639:Pirfenidone
2629:Peficitinib
2529:Canakinumab
2519:Briakinumab
2509:Bimekizumab
2504:Baricitinib
2469:Aflibercept
2380:Vepalimomab
2375:Vapaliximab
2350:Rovelizumab
2340:Pexelizumab
2330:Morolimumab
2305:Cedelizumab
2290:Anifrolumab
2285:Alemtuzumab
2243:Basiliximab
2213:Tocilizumab
2199:Vedolizumab
2194:Natalizumab
2180:Metelimumab
2123:Gavilimomab
2081:Toralizumab
2076:Teneliximab
2062:Lumiliximab
2057:Gomiliximab
2043:Ublituximab
2023:Ocrelizumab
1976:Zanolimumab
1952:Visilizumab
1910:Secukinumab
1894:Ustekinumab
1865:Elsilimomab
1849:Faralimomab
1817:Mepolizumab
1801:Ustekinumab
1796:Tocilizumab
1771:Secukinumab
1721:Canakinumab
1711:Briakinumab
1706:Bimekizumab
1701:Basiliximab
1690:Interleukin
1680:Nerelimomab
1585:Zotarolimus
1526:(reception)
1497:Thalidomide
1455:Voclosporin
1440:Ciclosporin
1434:Calcineurin
1430:Cyclophilin
1377:Leflunomide
1373:inhibitors
958:: 127–135.
729:10665/74420
397: g·mol
235:541502-14-1
220:Identifiers
105:Other names
96:Trade names
5023:Categories
4769:B (IFN-λ3)
4765:A (IFN-λ2)
4699:Guselkumab
4689:Brazikumab
4584:Fletikumab
4487:Remtolumab
4477:Ixekizumab
4472:Brodalumab
4355:Binetrakin
4293:Oprelvekin
4262:Ilodecakin
4241:Enokizumab
4154:Siltuximab
4144:Olokizumab
4078:Reslizumab
4012:Pitrakinra
3992:Binetrakin
3961:Milodistim
3956:Leridistim
3925:Inolimomab
3900:Teceleukin
3819:Isunakinra
3756:modulators
3616:Veltuzumab
3595:+emtansine
3567:Simtuzumab
3532:Pertuzumab
3462:Lintuzumab
3437:Glofitamab
3387:Elotuzumab
3372:Demcizumab
3312:Axatilimab
3302:Abituzumab
3274:Siltuximab
3249:Isatuximab
3189:Amatuximab
3161:Pintumomab
3131:Pemtumomab
3126:Oregovomab
3061:Bectumomab
3041:Abagovomab
2995:Tarextumab
2965:Radretumab
2960:Pritumumab
2950:Patritumab
2940:Olaratumab
2935:Ofatumumab
2925:Nesvacumab
2915:Narnatumab
2885:Iratumumab
2880:Ipilimumab
2850:Enoticumab
2830:Drozitumab
2758:for tumors
2699:Sutimlimab
2694:Spesolimab
2679:Siltuximab
2619:Olokizumab
2609:Ixekizumab
2604:Itacitinib
2594:Guselkumab
2589:Fingolimod
2584:Filgotinib
2534:Crovalimab
2524:Brodalumab
2514:Blisibimod
2479:Rilonacept
2462:Opinercept
2457:Etanercept
2443:Belatacept
2394:Polyclonal
2355:Siplizumab
2345:Reslizumab
2335:Ofatumumab
2325:Maslimomab
2310:Emapalumab
2253:Inolimomab
2248:Daclizumab
2227:Odulimomab
2142:Ruplizumab
2137:Frexalimab
2095:Aselizumab
1990:Efalizumab
1947:Teplizumab
1843:Interferon
1833:Omalizumab
1786:Spesolimab
1776:Siltuximab
1751:Rilonacept
1746:Olokizumab
1736:Ixekizumab
1731:Guselkumab
1726:Daclizumab
1716:Brodalumab
1675:Infliximab
1660:Afelimomab
1655:Adalimumab
1639:Eculizumab
1615:Monoclonal
1606:Antibodies
1580:Umirolimus
1560:Everolimus
1509:Apremilast
1469:Gusperimus
1450:Tacrolimus
1418:inhibitors
1410:Macrolides
1392:antifolate
1093:20 October
596:References
568:metastatic
436:. It is a
422:Siltuximab
386:Molar mass
291:T4H8FMA7IM
266:ChemSpider
226:CAS Number
133:Siltuximab
34:Siltuximab
4974:Unsorted:
4835:Agonists:
4814:Agonists:
4793:Agonists:
4753:Agonists:
4732:Agonists:
4676:Agonists:
4644:Agonists:
4603:Agonists:
4561:Agonists:
4533:Tadekinig
4515:Agonists:
4434:Agonists:
4408:Agonists:
4352:Agonists:
4311:Agonists:
4285:Agonists:
4259:Agonists:
4228:Agonists:
4187:Agonists:
4169:Levilimab
4159:Sirukumab
4149:Sarilumab
4106:Agonists:
4045:Agonists:
4022:Dupilumab
3989:Agonists:
3966:Muplestim
3943:Agonists:
3867:Agonists:
3794:Pifonakin
3789:Mobenakin
3772:Agonists:
3705:Phase III
3693:Withdrawn
3487:Naxitamab
3477:Matuzumab
3294:Humanized
3269:Rituximab
3234:Futuximab
3209:Cetuximab
3146:Solitomab
3106:Mitumomab
3096:Lilotomab
3076:Detumomab
3020:Votumumab
3010:Tovetumab
2930:Nivolumab
2895:Icrucumab
2865:Ganitumab
2689:Sirukumab
2684:Siponimod
2669:Sarilumab
2644:Ponesimod
2614:Netakimab
2599:Iptacopan
2579:Etrasimod
2539:Danicopan
2474:Alefacept
2438:Abatacept
2360:Talizumab
2300:Begelomab
2156:Belimumab
2109:Galiximab
2038:Rituximab
2004:Erlizumab
1971:Keliximab
1781:Sirukumab
1761:Sarilumab
1741:Netakimab
1670:Golimumab
1570:Sirolimus
1247:(1): 52.
476:indicated
5013:Medicine
4928:IL-22Rα1
4894:instead.
4211:instead.
4139:mAb 1339
4124:ARGX-109
4088:TPI ASM8
4058:YM-90709
3809:Anakinra
3804:AF-12198
3181:Chimeric
3091:Igovomab
2624:Ozanimod
2499:Avacopan
2492:Unsorted
2278:Unsorted
2188:Integrin
1921:Cellular
1696:Anakinra
1542:Anakinra
1464:Abetimus
1316: /
1273:27363832
1222:30691176
1214:28707587
1179:29140516
1171:24100967
1130:20625121
1087:Archived
1065:32034042
1057:21321981
1021:20808314
972:26854213
952:Cytokine
937:40363229
929:28140696
894:27904739
845:26634298
799:Archived
690:Archived
655:DailyMed
624:10 April
618:Archived
562:Research
442:proteins
438:chimeric
412:(verify)
246:DrugBank
144:ATC code
128:DailyMed
108:CNTO 328
63:Chimeric
4946:IL-10Rβ
4942:IL-20Rα
4932:IL-20Rβ
4866:IL-36RA
4411:ALT-803
2420:-cept (
1264:4929712
1012:2967052
885:5089324
542:History
430:Sylvant
347:Formula
255:DB09036
160:)
154: (
152:L04AC11
130::
100:Sylvant
18:Sylvant
4999:Portal
4902:Others
4875:Others
4827:IL1RL2
4806:IL1RL1
4543:IL18BP
3814:IL-1RA
3688:WHO-EM
2432:CTLA-4
2422:Fusion
1923:target
1904:IL-17A
1881:, and
1414:other
1271:
1261:
1220:
1212:
1177:
1169:
1128:
1063:
1055:
1019:
1009:
970:
935:
927:
892:
882:
843:
805:8 June
696:8 June
661:8 June
504:CYP450
500:CYP450
322:ChEMBL
311:D09669
202:℞-only
200:
187:
126:
79:Target
58:Source
4785:IL-31
4745:IL-28
4724:IL-27
4668:IL-23
4636:IL-22
4595:IL-21
4553:IL-20
4507:IL-18
4426:IL-17
4400:IL-15
4344:IL-13
4303:IL-12
4277:IL-11
4251:IL-10
3034:Mouse
2773:Human
2765:Tumor
2221:LFA-1
2131:CD154
1984:CD11a
1883:IL-23
1879:IL-13
1875:IL-12
1479:IMiDs
1218:S2CID
1175:S2CID
1061:S2CID
933:S2CID
763:(FDA)
759:U.S.
722:(2).
464:HHV-8
71:human
67:mouse
4892:here
4890:See
4220:IL-9
4209:here
4200:IL-8
4179:IL-7
4098:IL-6
4037:IL-5
3981:IL-4
3935:IL-3
3859:IL-2
3764:IL-1
2151:BLyS
2103:CD80
2070:CD40
2051:CD23
2012:CD20
1998:CD18
1859:IL-6
1552:mTOR
1426:FKBP
1416:IL-2
1269:PMID
1210:PMID
1167:PMID
1126:PMID
1095:2011
1053:PMID
1017:PMID
968:PMID
925:PMID
890:PMID
841:PMID
807:2024
698:2024
663:2024
626:2023
536:VEGF
530:and
373:2016
367:1688
361:9932
355:6450
302:KEGG
282:UNII
273:none
84:IL-6
48:Type
4918:CD4
4883:JAK
2164:CAT
1960:CD4
1931:CD3
1649:TNF
1322:L04
1259:PMC
1249:doi
1202:doi
1157:doi
1118:doi
1045:doi
1007:PMC
999:doi
995:103
960:doi
917:doi
880:PMC
872:doi
833:doi
724:hdl
466:).
460:HIV
426:INN
395:.21
393:983
391:144
157:WHO
5025::
4848:,
4844:,
4767:,
4459:,
4455:,
4451:,
4447:,
4443:,
3781:,
3701::
3593:/
1877:,
1267:.
1257:.
1243:.
1239:.
1216:.
1208:.
1198:25
1196:.
1173:.
1165:.
1153:19
1151:.
1147:.
1124:.
1114:28
1112:.
1085:.
1081:.
1059:.
1051:.
1041:71
1039:.
1015:.
1005:.
993:.
989:.
966:.
956:89
954:.
931:.
923:.
913:26
911:.
888:.
878:.
866:.
862:.
839:.
827:.
793:.
757:.
738:^
720:23
718:.
684:.
671:^
653:.
634:^
612:.
592:.
581:.
573:,
444:)
379:50
208:EU
196:US
189:S4
183:AU
123:US
5001::
4963:)
4944:/
4930:/
4920:)
4852:)
4850:γ
4846:β
4842:α
4840:(
4771:)
4763:(
4463:)
4461:F
4453:D
4449:C
4445:B
4441:A
4439:(
3785:)
3783:β
3779:α
3777:(
3745:e
3738:t
3731:v
3597:)
3589:(
2801:)
2797:(
2748:e
2741:t
2734:v
2575:)
2571:(
2424:)
2270:)
2266:(
2029:)
2025:(
1432:/
1428:/
1412:/
1324:)
1320:(
1306:e
1299:t
1292:v
1275:.
1251::
1245:9
1224:.
1204::
1181:.
1159::
1132:.
1120::
1097:.
1067:.
1047::
1023:.
1001::
974:.
962::
939:.
919::
896:.
874::
868:7
847:.
835::
829:8
809:.
780:.
732:.
726::
700:.
665:.
628:.
424:(
376:S
370:O
364:N
358:H
352:C
210::
198::
185::
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69:/
65:(
20:)
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