1245:(HPSE) cleaves off heparan sulfate to expose a binding site in the N-terminal region of syndecan-1's core protein. Three SDC1 elements are required. (1) The heparanase-exposed hydrophobic sequence GAGAL that promotes the alpha helicity of lacritin's C-terminal amphipathic alpha helix form and likely binds to the hydrophobic face. (2) Heparanase-cleaved heparan sulfate that is 3-O sulfated. This likely interacts with the cationic face of lacritin's C-terminal amphipathic alpha helix. (3) An N-terminal chondroitin sulfate chain that also likely binds to the cationic face. Point mutagenesis of lacritin has narrowed the ligation site.
301:
278:
175:
200:
552:
559:
307:
206:
1359:, but only if the cells tested are already known to be derived from blood. For plasma cells, it usually stains intensely membranous, with or without associated diffuse weak cytoplasmic and/or Golgi staining. Few cases show cytoplasmic granular staining, with or without associated Golgi staining.
1233:
chains, a highly conserved transmembrane domain, and a highly conserved cytoplasmic domain, which contains two constant regions that are separated by a variable region. The extracellular domain can be cleaved (shed) from the cell surface at a juxtamembrane site, converting the membrane-bound
50:
2990:"The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence"
2323:
Hassan H, Greve B, Pavao MS, Kiesel L, Ibrahim SA, Götte M (May 2013). "Syndecan-1 modulates β-integrin-dependent and interleukin-6-dependent functions in breast cancer cell adhesion, migration, and resistance to irradiation".
1195:
interactions via its receptor for extracellular matrix proteins. Syndecan-1 is a sponge for growth factors and chemokines, with binding largely via heparan sulfate chains. The syndecans mediate cell binding,
5319:
1818:"Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity"
2449:
Indatuximab
Ravtansine (BT062) In Combination With Lenalidomide and Low-Dose Dexamethasone In Patients With Relapsed and/Or Refractory Multiple Myeloma: Clinical Activity In Len/Dex-Refractory Patients
2231:
2803:
Ala-Kapee M, Nevanlinna H, Mali M, Jalkanen M, Schröder J (September 1990). "Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2".
1495:
Ala-Kapee M, Nevanlinna H, Mali M, Jalkanen M, Schröder J (September 1990). "Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2".
4143:
2369:"Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways"
2132:"Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis"
3219:
Kaukonen J, Alanen-Kurki L, Jalkanen M, Palotie A (March 1997). "The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p".
1252:
variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
3282:
3041:
Spring J, Goldberger OA, Jenkins NA, Gilbert DJ, Copeland NG, Bernfield M (June 1994). "Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family".
5312:
314:
213:
1881:
Averbeck M, Kuhn S, Bühligen J, Götte M, Simon JC, Polte T (November 2017). "Syndecan-1 regulates dendritic cell migration in cutaneous hypersensitivity to haptens".
5305:
4133:
3163:
Albini A, Benelli R, Presta M, Rusnati M, Ziche M, Rubartelli A, et al. (January 1996). "HIV-tat protein is a heparin-binding angiogenic growth factor".
2920:"Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region"
2766:
Kiefer MC, Ishihara M, Swiedler SJ, Crawford K, Stephans JC, Barr PJ (1992). "The molecular biology of heparan sulfate fibroblast growth factor receptors".
4113:
887:
3070:
Sneed TB, Stanley DJ, Young LA, Sanderson RD (February 1994). "Interleukin-6 regulates expression of the syndecan-1 proteoglycan on B lymphoid cells".
868:
136:
4975:
3299:
3275:
1297:
2737:
Vainio S, Jalkanen M, Bernfield M, Saxén L (August 1992). "Transient expression of syndecan in mesenchymal cell aggregates of the embryonic kidney".
5761:
5623:
4706:
3099:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
4694:
4472:
1587:
Bernfield M, Götte M, Park PW, Reizes O, Fitzgerald ML, Lincecum J, Zako M (1999). "Functions of cell surface heparan sulfate proteoglycans".
4758:
4753:
4699:
4479:
3260:
2663:
2628:
1436:
1418:
6306:
4212:
4138:
3268:
1241:
that binds syndecan-1 only after heparanase modification. Binding utilizes an enzyme-regulated 'off-on' switch in which active epithelial
1624:"Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site"
300:
6138:
5241:
5236:
5231:
5226:
4153:
2038:
1095:
277:
6178:
5206:
1102:
6028:
4442:
1867:
5010:
4504:
4190:
1405:
1384:
3130:"Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1"
2704:"Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts"
4649:
4185:
2477:
1401:
1764:"Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin"
199:
174:
47:
5511:
5146:
4618:
4613:
4558:
4292:
3741:
1380:
4840:
4563:
116:
6275:
5754:
4158:
2559:"Assessment of bone marrow plasma cell infiltrates in multiple myeloma: the added value of CD138 immunohistochemistry"
2515:"CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms"
2039:"Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction"
313:
212:
6265:
5328:
4870:
3295:
1293:
1226:
The syndecan-1 core protein consists of an extracellular domain which can be substituted with heparan sulfate and
6228:
6188:
3736:
2420:"Predictive value of syndecan-1 expression for the response to neoadjuvant chemotherapy of primary breast cancer"
1234:
proteoglycan into a paracrine effector molecule with roles in wound repair and invasive growth of cancer cells.
1214:
Altered syndecan-1 expression has been detected in several different tumor types. Syndecan 1 can be a marker for
1180:
306:
205:
6168:
6143:
4920:
3815:
932:
124:
5720:
4884:
913:
5739:
6311:
6203:
5747:
5701:
5478:
5468:
5391:
4227:
4222:
4217:
4207:
3514:
3442:
1996:
Rops AL, Götte M, Baselmans MH, van den Hoven MJ, Steenbergen EJ, Lensen JF, et al. (November 2007).
1344:
5381:
3571:
3489:
1673:"Inhibition by the soluble syndecan-1 ectodomains delays wound repair in mice overexpressing syndecan-1"
1289:
2083:"Enoxaparin improves the course of dextran sodium sulfate-induced colitis in syndecan-1-deficient mice"
1955:
Kharabi
Masouleh B, Ten Dam GB, Wild MK, Seelige R, van der Vlag J, Rops AL, et al. (April 2009).
4808:
4521:
3001:
2184:
1280:. This increase results in higher inflammatory responses and tissue damage in experimental models of
188:
103:
2171:
Binder
Gallimidi A, Nussbaum G, Hermano E, Weizman B, Meirovitz A, Vlodavsky I, et al. (2017).
6208:
6133:
6020:
5997:
5961:
5933:
4835:
4654:
1227:
1053:
1002:
2173:"Syndecan-1 deficiency promotes tumor growth in a murine model of colitis-induced colon carcinoma"
6158:
4242:
3976:
3244:
2828:
2791:
2491:
2349:
1906:
1741:
1569:
1520:
1281:
1249:
148:
2367:
Ibrahim SA, Gadalla R, El-Ghonaimy EA, Samir O, Mohamed HT, Hassan H, et al. (March 2017).
1078:
1057:
1027:
1006:
2448:
2037:
Vanhoutte D, Schellings MW, Götte M, Swinnen M, Herias V, Wild MK, et al. (January 2007).
1925:
6233:
6062:
3236:
3207:
3172:
3151:
3116:
3087:
3058:
3029:
2976:
2941:
2906:
2863:
2820:
2783:
2754:
2725:
2690:
2669:
2659:
2634:
2624:
2588:
2536:
2483:
2473:
2431:
2400:
2341:
2305:
2256:
2212:
2153:
2112:
2063:
2019:
1978:
1957:"Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity"
1937:
1898:
1849:
1793:
1733:
1694:
1653:
1604:
1561:
1512:
1477:
1230:
96:
40:
2842:"Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans"
1456:"Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans"
6148:
5965:
5918:
5441:
5015:
4748:
4669:
4232:
3425:
3351:
3228:
3197:
3141:
3108:
3079:
3050:
3019:
3009:
2966:
2931:
2896:
2888:
2853:
2812:
2775:
2746:
2715:
2651:
2616:
2611:
David G (1992). "Structural and
Functional Diversity of the Heparan Sulfate Proteoglycans".
2578:
2570:
2526:
2510:
2465:
2390:
2380:
2333:
2295:
2287:
2246:
2202:
2192:
2143:
2102:
2094:
2053:
2009:
1968:
1890:
1839:
1829:
1783:
1775:
1725:
1684:
1643:
1635:
1596:
1551:
1504:
1467:
1340:
1329:
1260:
Syndecan-1 deficient mice show increased inflammation, which was attributed to an increased
551:
393:
324:
268:
223:
2081:
Floer M, Götte M, Wild MK, Heidemann J, Gassar ES, Domschke W, et al. (January 2010).
6105:
6077:
5993:
5075:
3611:
3606:
3529:
2650:. Progress in Nucleic Acid Research and Molecular Biology. Vol. 63. pp. 109–38.
1305:
1273:
1169:
558:
368:
144:
5297:
3005:
2188:
6255:
5774:
5608:
5437:
5396:
4860:
4282:
3793:
3596:
2779:
2583:
2558:
2395:
2368:
2300:
2275:
2207:
2172:
2107:
2082:
1924:
Götte M, Joussen AM, Klein C, Andre P, Wagner DD, Hinkes MT, et al. (April 2002).
1844:
1817:
1788:
1763:
1648:
1623:
1197:
1188:
3146:
3129:
2901:
2876:
2858:
2841:
2720:
2703:
2655:
2058:
1762:
Ma P, Beck SL, Raab RW, McKown RL, Coffman GL, Utani A, et al. (September 2006).
1472:
1455:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
722:
717:
712:
707:
702:
697:
692:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
626:
610:
605:
600:
6300:
6260:
6248:
5928:
5580:
5552:
4830:
4287:
3378:
3112:
3024:
2989:
2750:
1600:
1325:
1324:
Altered syndecan-1 expression has been detected in several different tumor types. In
1309:
1192:
587:
3248:
2832:
2795:
2495:
2419:
2353:
1926:"Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature"
1910:
1745:
1573:
1524:
128:
6173:
6085:
5952:
5782:
5778:
5186:
4494:
4484:
4015:
3981:
1333:
1313:
1201:
1172:
386:
165:
2574:
2251:
2469:
2197:
1816:
Zhang Y, Wang N, Raab RW, McKown RL, Irwin JA, Kwon I, et al. (April 2013).
152:
6285:
6280:
6270:
6243:
6213:
6198:
6067:
5923:
5913:
5790:
5403:
5196:
4845:
4623:
4598:
4297:
3919:
3845:
3319:
2955:"Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans"
2620:
2615:. Advances in Experimental Medicine and Biology. Vol. 313. pp. 69–78.
2557:
Al-Quran SZ, Yang L, Magill JM, Braylan RC, Douglas-Nikitin VK (December 2007).
2531:
2514:
2418:
Götte M, Kersting C, Ruggiero M, Tio J, Tulusan AH, Kiesel L, Wülfing P (2006).
1441:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1423:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1356:
1277:
1269:
1215:
1184:
2994:
Proceedings of the
National Academy of Sciences of the United States of America
2877:"B lymphocytes express and lose syndecan at specific stages of differentiation"
2098:
469:
5358:
5354:
5337:
5126:
4850:
4531:
4148:
3781:
3776:
3771:
3626:
3410:
2385:
1998:"Syndecan-1 deficiency aggravates anti-glomerular basement membrane nephritis"
1729:
1265:
1242:
285:
182:
132:
2971:
2954:
2936:
2919:
2148:
2131:
1973:
1956:
6223:
6218:
6193:
6183:
6095:
4965:
4960:
4955:
4945:
4940:
4935:
4930:
3186:"Normalization and subtraction: two approaches to facilitate gene discovery"
3014:
2291:
1834:
1208:
1204:
organization and syndecan receptors are required for internalization of the
832:
529:
407:
352:
339:
251:
238:
140:
3083:
3054:
2694:
2673:
2592:
2540:
2487:
2435:
2404:
2345:
2309:
2260:
2216:
2157:
2116:
2067:
2023:
1982:
1941:
1902:
1853:
1797:
1737:
1698:
1689:
1672:
1657:
1608:
1565:
3240:
3232:
3211:
3176:
3155:
3120:
3091:
3062:
3033:
2980:
2945:
2910:
2867:
2824:
2787:
2758:
2729:
2638:
2014:
1997:
1779:
1556:
1539:
1516:
1481:
1142:
1137:
6042:
6037:
6032:
6010:
6005:
5983:
5978:
5938:
5271:
5171:
4985:
4970:
4173:
4168:
4076:
3766:
1238:
1176:
1126:
977:
958:
2460:
Rawstron AC (May 2006). "Chapter 6: Immunophenotyping of plasma cells".
6090:
5973:
5770:
5632:
5566:
5498:
5221:
5216:
5211:
5111:
4925:
4915:
4742:
4721:
4716:
4684:
4489:
4409:
4404:
4399:
4394:
4389:
4307:
4000:
3840:
3835:
3830:
3825:
3820:
3291:
3202:
3185:
2892:
2816:
2337:
1508:
1301:
1158:
944:
899:
1894:
1639:
73:
69:
6163:
5882:
5842:
5575:
5429:
5346:
5161:
5121:
5106:
5090:
5085:
5065:
5060:
4995:
4803:
4773:
4737:
4728:
4541:
4509:
4373:
4368:
4338:
4317:
4277:
4237:
4103:
4081:
4040:
3964:
3959:
3954:
3949:
3944:
3939:
3808:
3803:
3798:
3746:
3731:
3601:
3591:
3554:
3549:
3467:
3462:
2648:
Transcriptional regulation of
Syndecan-1 expression by growth factors
1671:
Elenius V, Götte M, Reizes O, Elenius K, Bernfield M (October 2004).
1285:
1261:
1110:
854:
2681:
Wijdenes J, Dore JM, Clement C, Vermot-Desroches C (2003). "CD138".
2274:
Stepp MA, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A (April 2015).
1713:
6057:
6052:
5897:
5892:
5887:
5877:
5872:
5867:
5847:
5832:
5827:
5812:
5799:
5668:
5588:
5363:
5286:
5261:
5181:
5176:
5166:
5156:
5141:
5136:
5131:
5116:
5070:
5055:
5020:
5005:
5000:
4990:
4910:
4905:
4900:
4879:
4875:
4865:
4778:
4679:
4674:
4633:
4583:
4578:
4573:
4568:
4553:
4546:
4526:
4514:
4457:
4452:
4447:
4437:
4432:
4425:
4363:
4353:
4348:
4343:
4333:
4312:
4302:
4267:
4262:
4257:
4252:
4247:
4202:
4197:
4163:
4128:
4123:
4118:
4108:
4096:
4091:
4071:
4066:
4061:
4056:
4010:
3902:
3897:
3716:
3700:
3693:
3688:
3683:
3678:
3673:
3668:
3643:
3621:
3616:
3509:
3435:
3430:
3420:
2702:
Lories V, Cassiman JJ, Van den Berghe H, David G (January 1992).
817:
813:
6238:
6153:
6047:
5862:
5857:
5852:
5837:
5822:
5817:
5807:
5728:
5706:
5681:
5676:
5658:
5654:
5649:
5644:
5640:
5613:
5603:
5598:
5593:
5516:
5506:
5488:
5483:
5473:
5407:
5386:
5376:
5371:
5281:
5276:
5266:
5256:
5251:
5246:
5201:
5191:
5151:
5080:
5050:
5045:
5040:
5035:
5030:
5025:
4980:
4950:
4855:
4823:
4818:
4798:
4788:
4783:
4768:
4763:
4664:
4659:
4628:
4608:
4603:
4593:
4588:
4467:
4420:
4380:
4035:
4030:
4025:
4020:
4005:
3996:
3991:
3986:
3971:
3929:
3924:
3914:
3909:
3892:
3887:
3882:
3877:
3872:
3867:
3862:
3857:
3852:
3788:
3761:
3756:
3751:
3726:
3721:
3658:
3653:
3648:
3638:
3633:
3586:
3581:
3576:
3566:
3561:
3544:
3539:
3534:
3524:
3519:
3504:
3499:
3494:
3484:
3479:
3474:
3457:
3452:
3447:
3398:
3366:
3361:
3356:
3339:
3334:
3329:
3324:
1165:
120:
5743:
5301:
3264:
2988:
Barillari G, Gendelman R, Gallo RC, Ensoli B (September 1993).
567:
5532:
5463:
5458:
5453:
5446:
4793:
3405:
3393:
3388:
3383:
3373:
3346:
3314:
1205:
1712:
Piperigkou Z, Mohr B, Karamanos N, Götte M (September 2016).
1179:
proteoglycan family. The syndecan-1 protein functions as an
2840:
Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (April 1990).
2130:
Zhang X, Wu C, Song J, Götte M, Sorokin L (November 2013).
1454:
Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (April 1990).
1622:
Wang Z, Götte M, Bernfield M, Reizes O (September 2005).
376:
2683:
Journal of
Biological Regulators and Homeostatic Agents
1332:
phenotype, which is linked to increased resistance to
748:
positive regulation of extracellular exosome assembly
541:
2875:
Sanderson RD, Lalor P, Bernfield M (November 1989).
1328:, syndecan-1 is up regulated and contributes to the
1308:, syndecan-1 deficiency promotes tumor growth in an
6126:
6104:
6076:
6019:
5992:
5960:
5951:
5906:
5798:
5789:
5719:
5694:
5667:
5631:
5622:
5574:
5565:
5545:
5525:
5497:
5428:
5421:
5345:
5336:
5099:
4893:
4642:
4326:
4049:
3709:
3307:
2232:"Therapeutic value of glycosaminoglycans in cancer"
1071:
1046:
1020:
995:
16:
Protein which in humans is encoded by the SDC1 gene
3184:Bonaldo MF, Lennon G, Soares MB (September 1996).
1397:
1395:
1393:
1376:
1374:
1372:
323:
222:
1930:Investigative Ophthalmology & Visual Science
1811:
1809:
1807:
2552:
2550:
2276:"Syndecan-1 and Its Expanding List of Contacts"
1757:
1755:
2230:Yip GW, Smollich M, Götte M (September 2006).
1402:GRCm38: Ensembl release 89: ENSMUSG00000020592
5755:
5313:
3276:
1264:and heparan sulfate-dependent recruitment of
8:
2953:Zhang L, David G, Esko JD (November 1995).
2464:. Vol. Chapter 6. pp. Unit 6.23.
1381:GRCh38: Ensembl release 89: ENSG00000115884
1168:. The protein is a transmembrane (type I)
5957:
5795:
5762:
5748:
5740:
5628:
5571:
5425:
5342:
5320:
5306:
5298:
3283:
3269:
3261:
2768:Annals of the New York Academy of Sciences
828:
583:
484:transitional epithelium of urinary bladder
364:
263:
160:
58:
3300:list of human clusters of differentiation
3201:
3145:
3023:
3013:
2970:
2935:
2900:
2857:
2719:
2582:
2530:
2394:
2384:
2299:
2250:
2206:
2196:
2147:
2106:
2057:
2013:
1972:
1843:
1833:
1787:
1688:
1647:
1555:
1471:
1298:experimental autoimmune encephalomyelitis
1237:An exception is the prosecretory mitogen
733:positive regulation of exosomal secretion
107:, CD138, SDC, SYND1, syndecan, syndecan 1
6068:Structural maintenance of chromosomes 3
3128:Kokenyesi R, Bernfield M (April 1994).
1368:
2519:American Journal of Clinical Pathology
718:glycosaminoglycan biosynthetic process
18:
2918:Asundi VK, Carey DJ (November 1995).
652:integral component of plasma membrane
328:
289:
284:
227:
186:
181:
7:
1714:"Shed proteoglycans in tumor stroma"
3134:The Journal of Biological Chemistry
2959:The Journal of Biological Chemistry
2924:The Journal of Biological Chemistry
2846:The Journal of Biological Chemistry
2805:Somatic Cell and Molecular Genetics
2708:The Journal of Biological Chemistry
2613:Heparin and Related Polysaccharides
1822:The Journal of Biological Chemistry
1677:The Journal of Biological Chemistry
1497:Somatic Cell and Molecular Genetics
1460:The Journal of Biological Chemistry
803:cytokine-mediated signaling pathway
778:glycosaminoglycan metabolic process
693:glycosaminoglycan catabolic process
2780:10.1111/j.1749-6632.1991.tb49027.x
1161:which in humans is encoded by the
1068:
1043:
1017:
992:
968:
949:
923:
904:
878:
859:
546:
464:
402:
381:
14:
6179:Cholesterylester transfer protein
6029:Chondroitin sulfate proteoglycans
2087:The American Journal of Pathology
2059:10.1161/CIRCULATIONAHA.106.644609
1601:10.1146/annurev.biochem.68.1.729
743:striated muscle cell development
672:external side of plasma membrane
557:
550:
312:
305:
299:
276:
211:
204:
198:
173:
2646:Jaakkola P, Jalkanen M (1999).
698:canonical Wnt signaling pathway
2462:Current Protocols in Cytometry
1868:"Entrez Gene: SDC1 syndecan 1"
642:integral component of membrane
568:More reference expression data
530:More reference expression data
1:
3147:10.1016/S0021-9258(17)32716-3
2859:10.1016/S0021-9258(19)39232-4
2721:10.1016/S0021-9258(18)48404-9
2656:10.1016/S0079-6603(08)60721-7
2575:10.1016/j.humpath.2007.04.010
2252:10.1158/1535-7163.MCT-06-0082
2239:Molecular Cancer Therapeutics
1589:Annual Review of Biochemistry
1473:10.1016/S0021-9258(19)39232-4
1316:-signaling-dependent manner.
773:response to hydrogen peroxide
768:response to organic substance
297:
196:
3113:10.1016/0378-1119(94)90802-8
2751:10.1016/0012-1606(92)90130-9
2470:10.1002/0471142956.cy0623s36
2198:10.1371/journal.pone.0174343
1339:It is a specific antigen on
6307:Genes on human chromosome 2
6276:Tumor necrosis factor alpha
3296:clusters of differentiation
2621:10.1007/978-1-4899-2444-5_7
2532:10.1309/617D-WB5G-NFWX-HW4L
1768:The Journal of Cell Biology
1540:"Syndecans in inflammation"
763:response to toxic substance
6328:
6266:Thyroxine-binding proteins
5329:Cluster of differentiation
2099:10.2353/ajpath.2010.080639
1355:It is a useful marker for
1294:inflammatory bowel disease
758:response to glucocorticoid
753:retinoid metabolic process
677:protein-containing complex
601:protein C-terminus binding
6229:Serum amyloid P component
6189:Colony-stimulating factor
2509:O'Connell FP, Pinkus JL,
2386:10.1186/s12943-017-0621-z
1730:10.1007/s00441-016-2452-4
1437:"Mouse PubMed Reference:"
1419:"Human PubMed Reference:"
1181:integral membrane protein
1141:
1136:
1132:
1125:
1109:
1090:
1075:
1050:
1039:
1024:
999:
988:
975:
971:
956:
952:
943:
930:
926:
911:
907:
898:
885:
881:
866:
862:
853:
838:
831:
827:
811:
611:identical protein binding
586:
582:
565:
549:
540:
527:
476:
467:
414:
405:
375:
367:
363:
346:
333:
296:
275:
266:
262:
245:
232:
195:
172:
163:
159:
114:
111:
101:
94:
89:
66:
61:
44:
39:
34:
30:
26:
21:
6169:B-cell activating factor
6144:Alpha 1-antichymotrypsin
2972:10.1074/jbc.270.45.27127
2937:10.1074/jbc.270.44.26404
2149:10.4049/jimmunol.1300931
1974:10.4049/jimmunol.0800574
1883:Experimental Dermatology
1718:Cell and Tissue Research
738:Sertoli cell development
723:ureteric bud development
3015:10.1073/pnas.90.17.7941
2292:10.1089/wound.2014.0555
1835:10.1074/jbc.M112.422717
1336:and radiation therapy
1175:and is a member of the
708:response to calcium ion
508:external carotid artery
330:12 A1.1|12 3.94 cM
6204:Membrane glycoproteins
3084:10.1006/cimm.1994.1042
3055:10.1006/geno.1994.1319
2280:Advances in Wound Care
1690:10.1074/jbc.M404506200
1538:Götte M (April 2003).
1347:targets this protein.
1345:Indatuximab ravtansine
1284:, inflammation of the
1103:Chr 12: 8.82 – 8.84 Mb
1096:Chr 2: 20.2 – 20.23 Mb
3233:10.1007/s004390050360
2739:Developmental Biology
2136:Journal of Immunology
2015:10.1038/sj.ki.5002514
1961:Journal of Immunology
1780:10.1083/jcb.200511134
1557:10.1096/fj.02-0739rev
1320:Clinical significance
1290:myocardial infarction
783:inflammatory response
632:extracellular exosome
291:Chromosome 12 (mouse)
2002:Kidney International
1183:and participates in
788:myoblast development
637:extracellular region
516:skin of external ear
189:Chromosome 2 (human)
62:List of PDB id codes
35:Available structures
6209:Myelin protein zero
6134:Activin and inhibin
5934:Phytohaemagglutinin
3140:(16): 12304–12309.
3072:Cellular Immunology
3006:1993PNAS...90.7941B
2965:(45): 27127–27135.
2930:(44): 26404–26410.
2424:Anticancer Research
2189:2017PLoSO..1274343B
1828:(17): 12090–12101.
1683:(40): 41928–41935.
1634:(37): 12355–12361.
1228:chondroitin sulfate
793:leukocyte migration
492:conjunctival fornix
450:gingival epithelium
426:right lobe of liver
6159:Asialoglycoprotein
3203:10.1101/gr.6.9.791
2893:10.1091/mbc.1.1.27
2817:10.1007/BF01233200
2338:10.1111/febs.12111
1509:10.1007/BF01233200
1282:contact dermatitis
1276:) to the inflamed
1185:cell proliferation
933:ENSMUSG00000020592
686:Biological process
620:Cellular component
594:Molecular function
6294:
6293:
6234:Sialoglycoprotein
6122:
6121:
6063:Platelet factor 4
5947:
5946:
5737:
5736:
5715:
5714:
5695:All (pan-myeloid)
5690:
5689:
5561:
5560:
5541:
5540:
5295:
5294:
3000:(17): 7941–7945.
2852:(12): 6884–6889.
2665:978-0-12-540063-3
2630:978-1-4899-2446-9
2569:(12): 1779–1787.
2513:(February 2004).
2332:(10): 2216–2227.
2008:(10): 1204–1215.
1895:10.1111/exd.13374
1889:(11): 1060–1067.
1640:10.1021/bi050620i
1466:(12): 6884–6889.
1231:glycosaminoglycan
1152:
1151:
1148:
1147:
1121:
1120:
1086:
1085:
1065:
1064:
1035:
1034:
1014:
1013:
984:
983:
965:
964:
939:
938:
920:
919:
894:
893:
875:
874:
823:
822:
578:
577:
574:
573:
536:
535:
523:
522:
461:
460:
422:mucosa of pharynx
359:
358:
258:
257:
85:
84:
81:
80:
45:Ortholog search:
6319:
6149:Apolipoprotein H
5958:
5919:Intrinsic factor
5796:
5764:
5757:
5750:
5741:
5629:
5572:
5426:
5343:
5322:
5315:
5308:
5299:
3285:
3278:
3271:
3262:
3252:
3215:
3205:
3180:
3159:
3149:
3124:
3107:(1–2): 171–174.
3095:
3066:
3037:
3027:
3017:
2984:
2974:
2949:
2939:
2914:
2904:
2871:
2861:
2836:
2799:
2762:
2733:
2723:
2714:(2): 1116–1122.
2698:
2677:
2642:
2597:
2596:
2586:
2554:
2545:
2544:
2534:
2506:
2500:
2499:
2457:
2451:
2446:
2440:
2439:
2415:
2409:
2408:
2398:
2388:
2373:Molecular Cancer
2364:
2358:
2357:
2326:The FEBS Journal
2320:
2314:
2313:
2303:
2271:
2265:
2264:
2254:
2245:(9): 2139–2148.
2236:
2227:
2221:
2220:
2210:
2200:
2168:
2162:
2161:
2151:
2142:(9): 4551–4561.
2127:
2121:
2120:
2110:
2078:
2072:
2071:
2061:
2043:
2034:
2028:
2027:
2017:
1993:
1987:
1986:
1976:
1967:(8): 4985–4993.
1952:
1946:
1945:
1936:(4): 1135–1141.
1921:
1915:
1914:
1878:
1872:
1871:
1864:
1858:
1857:
1847:
1837:
1813:
1802:
1801:
1791:
1774:(7): 1097–1106.
1759:
1750:
1749:
1709:
1703:
1702:
1692:
1668:
1662:
1661:
1651:
1619:
1613:
1612:
1584:
1578:
1577:
1559:
1535:
1529:
1528:
1492:
1486:
1485:
1475:
1451:
1445:
1444:
1433:
1427:
1426:
1415:
1409:
1399:
1388:
1378:
1341:multiple myeloma
1330:cancer stem cell
1300:In experimental
1134:
1133:
1105:
1098:
1081:
1069:
1060:
1044:
1040:RefSeq (protein)
1030:
1018:
1009:
993:
969:
950:
924:
905:
879:
860:
829:
728:response to cAMP
584:
570:
561:
554:
547:
532:
472:
470:Top expressed in
465:
410:
408:Top expressed in
403:
382:
365:
355:
342:
331:
316:
309:
303:
292:
280:
264:
254:
241:
230:
215:
208:
202:
191:
177:
161:
155:
153:SDC1 - orthologs
106:
99:
76:
59:
53:
32:
31:
19:
6327:
6326:
6322:
6321:
6320:
6318:
6317:
6316:
6297:
6296:
6295:
6290:
6118:
6100:
6072:
6015:
5988:
5943:
5902:
5785:
5768:
5738:
5733:
5711:
5686:
5663:
5618:
5579:
5557:
5537:
5521:
5493:
5417:
5332:
5326:
5296:
5291:
5095:
4889:
4638:
4322:
4045:
3705:
3303:
3289:
3255:
3218:
3190:Genome Research
3183:
3162:
3127:
3098:
3069:
3040:
2987:
2952:
2917:
2881:Cell Regulation
2874:
2839:
2802:
2765:
2736:
2701:
2680:
2666:
2645:
2631:
2610:
2606:
2604:Further reading
2601:
2600:
2563:Human Pathology
2556:
2555:
2548:
2508:
2507:
2503:
2480:
2459:
2458:
2454:
2447:
2443:
2430:(1B): 621–627.
2417:
2416:
2412:
2366:
2365:
2361:
2322:
2321:
2317:
2273:
2272:
2268:
2234:
2229:
2228:
2224:
2183:(3): e0174343.
2170:
2169:
2165:
2129:
2128:
2124:
2080:
2079:
2075:
2041:
2036:
2035:
2031:
1995:
1994:
1990:
1954:
1953:
1949:
1923:
1922:
1918:
1880:
1879:
1875:
1866:
1865:
1861:
1815:
1814:
1805:
1761:
1760:
1753:
1711:
1710:
1706:
1670:
1669:
1665:
1621:
1620:
1616:
1586:
1585:
1581:
1537:
1536:
1532:
1494:
1493:
1489:
1453:
1452:
1448:
1435:
1434:
1430:
1417:
1416:
1412:
1400:
1391:
1379:
1370:
1365:
1353:
1322:
1306:colon carcinoma
1274:dendritic cells
1258:
1224:
1170:heparan sulfate
1143:View/Edit Mouse
1138:View/Edit Human
1101:
1094:
1091:Location (UCSC)
1077:
1056:
1052:
1026:
1005:
1001:
914:ENSG00000115884
807:
681:
667:plasma membrane
627:lysosomal lumen
615:
606:protein binding
566:
556:
555:
528:
519:
514:
510:
506:
502:
498:
496:skin of abdomen
494:
490:
486:
482:
468:
457:
452:
448:
444:
440:
436:
432:
428:
424:
420:
418:skin of abdomen
406:
350:
337:
329:
319:
318:
317:
310:
290:
267:Gene location (
249:
236:
228:
218:
217:
216:
209:
187:
164:Gene location (
115:
102:
95:
68:
46:
17:
12:
11:
5:
6325:
6323:
6315:
6314:
6309:
6299:
6298:
6292:
6291:
6289:
6288:
6283:
6278:
6273:
6268:
6263:
6258:
6256:Thrombopoietin
6253:
6252:
6251:
6246:
6241:
6231:
6226:
6221:
6216:
6211:
6206:
6201:
6196:
6191:
6186:
6181:
6176:
6171:
6166:
6161:
6156:
6151:
6146:
6141:
6136:
6130:
6128:
6124:
6123:
6120:
6119:
6117:
6116:
6110:
6108:
6102:
6101:
6099:
6098:
6093:
6088:
6082:
6080:
6074:
6073:
6071:
6070:
6065:
6060:
6055:
6050:
6045:
6040:
6035:
6025:
6023:
6017:
6016:
6014:
6013:
6008:
6002:
6000:
5990:
5989:
5987:
5986:
5981:
5976:
5970:
5968:
5955:
5949:
5948:
5945:
5944:
5942:
5941:
5936:
5931:
5926:
5921:
5916:
5910:
5908:
5904:
5903:
5901:
5900:
5895:
5890:
5885:
5880:
5875:
5870:
5865:
5860:
5855:
5850:
5845:
5840:
5835:
5830:
5825:
5820:
5815:
5810:
5804:
5802:
5793:
5787:
5786:
5775:glycoconjugate
5769:
5767:
5766:
5759:
5752:
5744:
5735:
5734:
5732:
5731:
5725:
5723:
5717:
5716:
5713:
5712:
5710:
5709:
5704:
5698:
5696:
5692:
5691:
5688:
5687:
5685:
5684:
5679:
5673:
5671:
5665:
5664:
5662:
5661:
5652:
5647:
5637:
5635:
5626:
5620:
5619:
5617:
5616:
5611:
5606:
5601:
5596:
5591:
5585:
5583:
5569:
5563:
5562:
5559:
5558:
5556:
5555:
5549:
5547:
5543:
5542:
5539:
5538:
5536:
5535:
5529:
5527:
5523:
5522:
5520:
5519:
5514:
5509:
5503:
5501:
5495:
5494:
5492:
5491:
5486:
5481:
5476:
5471:
5466:
5461:
5456:
5450:
5449:
5444:
5438:Pan-T antigens
5434:
5432:
5423:
5419:
5418:
5416:
5415:
5410:
5400:
5399:
5394:
5389:
5384:
5379:
5374:
5367:
5366:
5361:
5351:
5349:
5340:
5334:
5333:
5327:
5325:
5324:
5317:
5310:
5302:
5293:
5292:
5290:
5289:
5284:
5279:
5274:
5269:
5264:
5259:
5254:
5249:
5244:
5239:
5234:
5229:
5224:
5219:
5214:
5209:
5204:
5199:
5194:
5189:
5184:
5179:
5174:
5169:
5164:
5159:
5154:
5149:
5144:
5139:
5134:
5129:
5124:
5119:
5114:
5109:
5103:
5101:
5097:
5096:
5094:
5093:
5088:
5083:
5078:
5073:
5068:
5063:
5058:
5053:
5048:
5043:
5038:
5033:
5028:
5023:
5018:
5013:
5008:
5003:
4998:
4993:
4988:
4983:
4978:
4973:
4968:
4963:
4958:
4953:
4948:
4943:
4938:
4933:
4928:
4923:
4918:
4913:
4908:
4903:
4897:
4895:
4891:
4890:
4888:
4887:
4882:
4873:
4868:
4863:
4858:
4853:
4848:
4843:
4838:
4833:
4828:
4827:
4826:
4821:
4811:
4806:
4801:
4796:
4791:
4786:
4781:
4776:
4771:
4766:
4761:
4756:
4751:
4746:
4740:
4731:
4726:
4725:
4724:
4719:
4709:
4704:
4703:
4702:
4697:
4687:
4682:
4677:
4672:
4667:
4662:
4657:
4652:
4646:
4644:
4640:
4639:
4637:
4636:
4631:
4626:
4621:
4616:
4611:
4606:
4601:
4596:
4591:
4586:
4581:
4576:
4571:
4566:
4561:
4556:
4551:
4550:
4549:
4544:
4534:
4529:
4524:
4519:
4518:
4517:
4512:
4507:
4497:
4492:
4487:
4482:
4477:
4476:
4475:
4470:
4460:
4455:
4450:
4445:
4440:
4435:
4430:
4429:
4428:
4423:
4413:
4407:
4402:
4397:
4392:
4383:
4378:
4377:
4376:
4371:
4366:
4356:
4351:
4346:
4341:
4336:
4330:
4328:
4324:
4323:
4321:
4320:
4315:
4310:
4305:
4300:
4295:
4290:
4285:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4205:
4200:
4195:
4194:
4193:
4188:
4178:
4177:
4176:
4171:
4161:
4156:
4151:
4146:
4141:
4136:
4131:
4126:
4121:
4116:
4111:
4106:
4101:
4100:
4099:
4094:
4084:
4079:
4074:
4069:
4064:
4059:
4053:
4051:
4047:
4046:
4044:
4043:
4038:
4033:
4028:
4023:
4018:
4013:
4008:
4003:
3994:
3989:
3984:
3979:
3974:
3969:
3968:
3967:
3962:
3957:
3952:
3947:
3942:
3932:
3927:
3922:
3917:
3912:
3907:
3906:
3905:
3900:
3890:
3885:
3880:
3875:
3870:
3865:
3860:
3855:
3850:
3849:
3848:
3843:
3838:
3833:
3828:
3823:
3813:
3812:
3811:
3806:
3801:
3791:
3786:
3785:
3784:
3779:
3774:
3764:
3759:
3754:
3749:
3744:
3739:
3734:
3729:
3724:
3719:
3713:
3711:
3707:
3706:
3704:
3703:
3698:
3697:
3696:
3691:
3686:
3681:
3676:
3671:
3661:
3656:
3651:
3646:
3641:
3636:
3631:
3630:
3629:
3624:
3619:
3614:
3604:
3599:
3594:
3589:
3584:
3579:
3574:
3569:
3564:
3559:
3558:
3557:
3552:
3542:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3477:
3472:
3471:
3470:
3465:
3455:
3450:
3445:
3440:
3439:
3438:
3433:
3428:
3423:
3413:
3408:
3403:
3402:
3401:
3391:
3386:
3381:
3376:
3371:
3370:
3369:
3364:
3359:
3349:
3344:
3343:
3342:
3337:
3332:
3327:
3322:
3311:
3309:
3305:
3304:
3290:
3288:
3287:
3280:
3273:
3265:
3259:
3258:
3254:
3253:
3227:(3): 295–297.
3221:Human Genetics
3216:
3196:(9): 791–806.
3181:
3171:(2): 289–297.
3160:
3125:
3096:
3078:(2): 456–467.
3067:
3049:(3): 597–601.
3038:
2985:
2950:
2915:
2872:
2837:
2811:(5): 501–505.
2800:
2763:
2745:(2): 221–232.
2734:
2699:
2689:(2): 152–155.
2678:
2664:
2643:
2629:
2607:
2605:
2602:
2599:
2598:
2546:
2525:(2): 254–263.
2501:
2478:
2452:
2441:
2410:
2359:
2315:
2286:(4): 235–249.
2266:
2222:
2163:
2122:
2093:(1): 146–157.
2073:
2052:(4): 475–482.
2029:
1988:
1947:
1916:
1873:
1859:
1803:
1751:
1724:(3): 643–655.
1704:
1663:
1614:
1579:
1550:(6): 575–591.
1530:
1503:(5): 501–505.
1487:
1446:
1428:
1410:
1389:
1367:
1366:
1364:
1361:
1352:
1349:
1321:
1318:
1257:
1254:
1248:While several
1223:
1220:
1198:cell signaling
1189:cell migration
1150:
1149:
1146:
1145:
1140:
1130:
1129:
1123:
1122:
1119:
1118:
1116:
1114:
1107:
1106:
1099:
1092:
1088:
1087:
1084:
1083:
1073:
1072:
1066:
1063:
1062:
1048:
1047:
1041:
1037:
1036:
1033:
1032:
1022:
1021:
1015:
1012:
1011:
997:
996:
990:
986:
985:
982:
981:
973:
972:
966:
963:
962:
954:
953:
947:
941:
940:
937:
936:
928:
927:
921:
918:
917:
909:
908:
902:
896:
895:
892:
891:
883:
882:
876:
873:
872:
864:
863:
857:
851:
850:
845:
840:
836:
835:
825:
824:
821:
820:
809:
808:
806:
805:
800:
798:cell migration
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
725:
720:
715:
710:
705:
700:
695:
689:
687:
683:
682:
680:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
629:
623:
621:
617:
616:
614:
613:
608:
603:
597:
595:
591:
590:
580:
579:
576:
575:
572:
571:
563:
562:
544:
538:
537:
534:
533:
525:
524:
521:
520:
518:
517:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
474:
473:
462:
459:
458:
456:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
412:
411:
399:
398:
390:
379:
373:
372:
369:RNA expression
361:
360:
357:
356:
348:
344:
343:
335:
332:
327:
321:
320:
311:
304:
298:
294:
293:
288:
282:
281:
273:
272:
260:
259:
256:
255:
247:
243:
242:
234:
231:
226:
220:
219:
210:
203:
197:
193:
192:
185:
179:
178:
170:
169:
157:
156:
113:
109:
108:
100:
92:
91:
87:
86:
83:
82:
79:
78:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
6324:
6313:
6312:Proteoglycans
6310:
6308:
6305:
6304:
6302:
6287:
6284:
6282:
6279:
6277:
6274:
6272:
6269:
6267:
6264:
6262:
6261:Thyroglobulin
6259:
6257:
6254:
6250:
6249:Glycophorin C
6247:
6245:
6242:
6240:
6237:
6236:
6235:
6232:
6230:
6227:
6225:
6222:
6220:
6217:
6215:
6212:
6210:
6207:
6205:
6202:
6200:
6197:
6195:
6192:
6190:
6187:
6185:
6182:
6180:
6177:
6175:
6172:
6170:
6167:
6165:
6162:
6160:
6157:
6155:
6152:
6150:
6147:
6145:
6142:
6140:
6137:
6135:
6132:
6131:
6129:
6125:
6115:
6112:
6111:
6109:
6107:
6103:
6097:
6094:
6092:
6089:
6087:
6084:
6083:
6081:
6079:
6075:
6069:
6066:
6064:
6061:
6059:
6056:
6054:
6051:
6049:
6046:
6044:
6041:
6039:
6036:
6034:
6030:
6027:
6026:
6024:
6022:
6018:
6012:
6009:
6007:
6004:
6003:
6001:
5999:
5995:
5991:
5985:
5982:
5980:
5977:
5975:
5972:
5971:
5969:
5967:
5963:
5959:
5956:
5954:
5953:Proteoglycans
5950:
5940:
5937:
5935:
5932:
5930:
5929:Peptidoglycan
5927:
5925:
5922:
5920:
5917:
5915:
5912:
5911:
5909:
5905:
5899:
5896:
5894:
5891:
5889:
5886:
5884:
5881:
5879:
5876:
5874:
5871:
5869:
5866:
5864:
5861:
5859:
5856:
5854:
5851:
5849:
5846:
5844:
5841:
5839:
5836:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5809:
5806:
5805:
5803:
5801:
5797:
5794:
5792:
5788:
5784:
5783:glycopeptides
5780:
5779:glycoproteins
5776:
5772:
5765:
5760:
5758:
5753:
5751:
5746:
5745:
5742:
5730:
5727:
5726:
5724:
5722:
5718:
5708:
5705:
5703:
5700:
5699:
5697:
5693:
5683:
5680:
5678:
5675:
5674:
5672:
5670:
5666:
5660:
5656:
5653:
5651:
5648:
5646:
5642:
5639:
5638:
5636:
5634:
5630:
5627:
5625:
5621:
5615:
5612:
5610:
5607:
5605:
5602:
5600:
5597:
5595:
5592:
5590:
5587:
5586:
5584:
5582:
5581:Myelomonocyte
5577:
5573:
5570:
5568:
5564:
5554:
5551:
5550:
5548:
5544:
5534:
5531:
5530:
5528:
5524:
5518:
5515:
5513:
5510:
5508:
5505:
5504:
5502:
5500:
5496:
5490:
5487:
5485:
5482:
5480:
5477:
5475:
5472:
5470:
5467:
5465:
5462:
5460:
5457:
5455:
5452:
5451:
5448:
5445:
5443:
5439:
5436:
5435:
5433:
5431:
5427:
5424:
5420:
5414:
5411:
5409:
5405:
5402:
5401:
5398:
5395:
5393:
5390:
5388:
5385:
5383:
5380:
5378:
5375:
5373:
5369:
5368:
5365:
5362:
5360:
5356:
5353:
5352:
5350:
5348:
5344:
5341:
5339:
5335:
5330:
5323:
5318:
5316:
5311:
5309:
5304:
5303:
5300:
5288:
5285:
5283:
5280:
5278:
5275:
5273:
5270:
5268:
5265:
5263:
5260:
5258:
5255:
5253:
5250:
5248:
5245:
5243:
5240:
5238:
5235:
5233:
5230:
5228:
5225:
5223:
5220:
5218:
5215:
5213:
5210:
5208:
5205:
5203:
5200:
5198:
5195:
5193:
5190:
5188:
5185:
5183:
5180:
5178:
5175:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5148:
5145:
5143:
5140:
5138:
5135:
5133:
5130:
5128:
5125:
5123:
5120:
5118:
5115:
5113:
5110:
5108:
5105:
5104:
5102:
5098:
5092:
5089:
5087:
5084:
5082:
5079:
5077:
5074:
5072:
5069:
5067:
5064:
5062:
5059:
5057:
5054:
5052:
5049:
5047:
5044:
5042:
5039:
5037:
5034:
5032:
5029:
5027:
5024:
5022:
5019:
5017:
5014:
5012:
5009:
5007:
5004:
5002:
4999:
4997:
4994:
4992:
4989:
4987:
4984:
4982:
4979:
4977:
4974:
4972:
4969:
4967:
4964:
4962:
4959:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4934:
4932:
4929:
4927:
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4898:
4896:
4892:
4886:
4883:
4881:
4877:
4874:
4872:
4869:
4867:
4864:
4862:
4859:
4857:
4854:
4852:
4849:
4847:
4844:
4842:
4839:
4837:
4834:
4832:
4829:
4825:
4822:
4820:
4817:
4816:
4815:
4812:
4810:
4807:
4805:
4802:
4800:
4797:
4795:
4792:
4790:
4787:
4785:
4782:
4780:
4777:
4775:
4772:
4770:
4767:
4765:
4762:
4760:
4757:
4755:
4752:
4750:
4747:
4744:
4741:
4739:
4735:
4732:
4730:
4727:
4723:
4720:
4718:
4715:
4714:
4713:
4710:
4708:
4705:
4701:
4698:
4696:
4693:
4692:
4691:
4688:
4686:
4683:
4681:
4678:
4676:
4673:
4671:
4668:
4666:
4663:
4661:
4658:
4656:
4653:
4651:
4648:
4647:
4645:
4641:
4635:
4632:
4630:
4627:
4625:
4622:
4620:
4617:
4615:
4612:
4610:
4607:
4605:
4602:
4600:
4597:
4595:
4592:
4590:
4587:
4585:
4582:
4580:
4577:
4575:
4572:
4570:
4567:
4565:
4562:
4560:
4557:
4555:
4552:
4548:
4545:
4543:
4540:
4539:
4538:
4535:
4533:
4530:
4528:
4525:
4523:
4520:
4516:
4513:
4511:
4508:
4506:
4503:
4502:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4474:
4471:
4469:
4466:
4465:
4464:
4461:
4459:
4456:
4454:
4451:
4449:
4446:
4444:
4441:
4439:
4436:
4434:
4431:
4427:
4424:
4422:
4419:
4418:
4417:
4414:
4411:
4408:
4406:
4403:
4401:
4398:
4396:
4393:
4391:
4387:
4384:
4382:
4379:
4375:
4372:
4370:
4367:
4365:
4362:
4361:
4360:
4357:
4355:
4352:
4350:
4347:
4345:
4342:
4340:
4337:
4335:
4332:
4331:
4329:
4325:
4319:
4316:
4314:
4311:
4309:
4306:
4304:
4301:
4299:
4296:
4294:
4291:
4289:
4286:
4284:
4281:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4204:
4201:
4199:
4196:
4192:
4189:
4187:
4184:
4183:
4182:
4179:
4175:
4172:
4170:
4167:
4166:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4105:
4102:
4098:
4095:
4093:
4090:
4089:
4088:
4085:
4083:
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4054:
4052:
4048:
4042:
4039:
4037:
4034:
4032:
4029:
4027:
4024:
4022:
4019:
4017:
4014:
4012:
4009:
4007:
4004:
4002:
3998:
3995:
3993:
3990:
3988:
3985:
3983:
3980:
3978:
3975:
3973:
3970:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3937:
3936:
3933:
3931:
3928:
3926:
3923:
3921:
3918:
3916:
3913:
3911:
3908:
3904:
3901:
3899:
3896:
3895:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3869:
3866:
3864:
3861:
3859:
3856:
3854:
3851:
3847:
3844:
3842:
3839:
3837:
3834:
3832:
3829:
3827:
3824:
3822:
3819:
3818:
3817:
3814:
3810:
3807:
3805:
3802:
3800:
3797:
3796:
3795:
3792:
3790:
3787:
3783:
3780:
3778:
3775:
3773:
3770:
3769:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3714:
3712:
3708:
3702:
3699:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3666:
3665:
3662:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3628:
3625:
3623:
3620:
3618:
3615:
3613:
3610:
3609:
3608:
3605:
3603:
3600:
3598:
3595:
3593:
3590:
3588:
3585:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3563:
3560:
3556:
3553:
3551:
3548:
3547:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3469:
3466:
3464:
3461:
3460:
3459:
3456:
3454:
3451:
3449:
3446:
3444:
3441:
3437:
3434:
3432:
3429:
3427:
3424:
3422:
3419:
3418:
3417:
3414:
3412:
3409:
3407:
3404:
3400:
3397:
3396:
3395:
3392:
3390:
3387:
3385:
3382:
3380:
3377:
3375:
3372:
3368:
3365:
3363:
3360:
3358:
3355:
3354:
3353:
3350:
3348:
3345:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3321:
3318:
3317:
3316:
3313:
3312:
3310:
3306:
3301:
3297:
3293:
3286:
3281:
3279:
3274:
3272:
3267:
3266:
3263:
3257:
3256:
3250:
3246:
3242:
3238:
3234:
3230:
3226:
3222:
3217:
3213:
3209:
3204:
3199:
3195:
3191:
3187:
3182:
3178:
3174:
3170:
3166:
3161:
3157:
3153:
3148:
3143:
3139:
3135:
3131:
3126:
3122:
3118:
3114:
3110:
3106:
3102:
3097:
3093:
3089:
3085:
3081:
3077:
3073:
3068:
3064:
3060:
3056:
3052:
3048:
3044:
3039:
3035:
3031:
3026:
3021:
3016:
3011:
3007:
3003:
2999:
2995:
2991:
2986:
2982:
2978:
2973:
2968:
2964:
2960:
2956:
2951:
2947:
2943:
2938:
2933:
2929:
2925:
2921:
2916:
2912:
2908:
2903:
2898:
2894:
2890:
2886:
2882:
2878:
2873:
2869:
2865:
2860:
2855:
2851:
2847:
2843:
2838:
2834:
2830:
2826:
2822:
2818:
2814:
2810:
2806:
2801:
2797:
2793:
2789:
2785:
2781:
2777:
2773:
2769:
2764:
2760:
2756:
2752:
2748:
2744:
2740:
2735:
2731:
2727:
2722:
2717:
2713:
2709:
2705:
2700:
2696:
2692:
2688:
2684:
2679:
2675:
2671:
2667:
2661:
2657:
2653:
2649:
2644:
2640:
2636:
2632:
2626:
2622:
2618:
2614:
2609:
2608:
2603:
2594:
2590:
2585:
2580:
2576:
2572:
2568:
2564:
2560:
2553:
2551:
2547:
2542:
2538:
2533:
2528:
2524:
2520:
2516:
2512:
2505:
2502:
2497:
2493:
2489:
2485:
2481:
2475:
2471:
2467:
2463:
2456:
2453:
2450:
2445:
2442:
2437:
2433:
2429:
2425:
2421:
2414:
2411:
2406:
2402:
2397:
2392:
2387:
2382:
2378:
2374:
2370:
2363:
2360:
2355:
2351:
2347:
2343:
2339:
2335:
2331:
2327:
2319:
2316:
2311:
2307:
2302:
2297:
2293:
2289:
2285:
2281:
2277:
2270:
2267:
2262:
2258:
2253:
2248:
2244:
2240:
2233:
2226:
2223:
2218:
2214:
2209:
2204:
2199:
2194:
2190:
2186:
2182:
2178:
2174:
2167:
2164:
2159:
2155:
2150:
2145:
2141:
2137:
2133:
2126:
2123:
2118:
2114:
2109:
2104:
2100:
2096:
2092:
2088:
2084:
2077:
2074:
2069:
2065:
2060:
2055:
2051:
2047:
2040:
2033:
2030:
2025:
2021:
2016:
2011:
2007:
2003:
1999:
1992:
1989:
1984:
1980:
1975:
1970:
1966:
1962:
1958:
1951:
1948:
1943:
1939:
1935:
1931:
1927:
1920:
1917:
1912:
1908:
1904:
1900:
1896:
1892:
1888:
1884:
1877:
1874:
1869:
1863:
1860:
1855:
1851:
1846:
1841:
1836:
1831:
1827:
1823:
1819:
1812:
1810:
1808:
1804:
1799:
1795:
1790:
1785:
1781:
1777:
1773:
1769:
1765:
1758:
1756:
1752:
1747:
1743:
1739:
1735:
1731:
1727:
1723:
1719:
1715:
1708:
1705:
1700:
1696:
1691:
1686:
1682:
1678:
1674:
1667:
1664:
1659:
1655:
1650:
1645:
1641:
1637:
1633:
1629:
1625:
1618:
1615:
1610:
1606:
1602:
1598:
1594:
1590:
1583:
1580:
1575:
1571:
1567:
1563:
1558:
1553:
1549:
1545:
1544:FASEB Journal
1541:
1534:
1531:
1526:
1522:
1518:
1514:
1510:
1506:
1502:
1498:
1491:
1488:
1483:
1479:
1474:
1469:
1465:
1461:
1457:
1450:
1447:
1442:
1438:
1432:
1429:
1424:
1420:
1414:
1411:
1407:
1403:
1398:
1396:
1394:
1390:
1386:
1382:
1377:
1375:
1373:
1369:
1362:
1360:
1358:
1350:
1348:
1346:
1342:
1337:
1335:
1331:
1327:
1326:breast cancer
1319:
1317:
1315:
1311:
1307:
1303:
1299:
1295:
1291:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1255:
1253:
1251:
1246:
1244:
1240:
1235:
1232:
1229:
1221:
1219:
1217:
1212:
1210:
1207:
1203:
1199:
1194:
1190:
1186:
1182:
1178:
1174:
1171:
1167:
1164:
1160:
1156:
1144:
1139:
1135:
1131:
1128:
1124:
1117:
1115:
1112:
1108:
1104:
1100:
1097:
1093:
1089:
1082:
1080:
1074:
1070:
1067:
1061:
1059:
1055:
1049:
1045:
1042:
1038:
1031:
1029:
1023:
1019:
1016:
1010:
1008:
1004:
998:
994:
991:
989:RefSeq (mRNA)
987:
980:
979:
974:
970:
967:
961:
960:
955:
951:
948:
946:
942:
935:
934:
929:
925:
922:
916:
915:
910:
906:
903:
901:
897:
890:
889:
884:
880:
877:
871:
870:
865:
861:
858:
856:
852:
849:
846:
844:
841:
837:
834:
830:
826:
819:
815:
810:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
719:
716:
714:
713:odontogenesis
711:
709:
706:
704:
703:wound healing
701:
699:
696:
694:
691:
690:
688:
685:
684:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
624:
622:
619:
618:
612:
609:
607:
604:
602:
599:
598:
596:
593:
592:
589:
588:Gene ontology
585:
581:
569:
564:
560:
553:
548:
545:
543:
539:
531:
526:
515:
511:
507:
504:hair follicle
503:
499:
495:
491:
487:
483:
479:
478:
475:
471:
466:
463:
453:
449:
446:skin of thigh
445:
441:
437:
433:
429:
425:
421:
417:
416:
413:
409:
404:
401:
400:
397:
395:
391:
389:
388:
384:
383:
380:
378:
374:
370:
366:
362:
354:
349:
345:
341:
336:
326:
322:
315:
308:
302:
295:
287:
283:
279:
274:
270:
265:
261:
253:
248:
244:
240:
235:
225:
221:
214:
207:
201:
194:
190:
184:
180:
176:
171:
167:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
110:
105:
98:
93:
88:
77:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
6174:4-1BB ligand
6113:
6086:Fibromodulin
5791:Mucoproteins
5412:
4813:
4733:
4711:
4689:
4536:
4499:
4462:
4415:
4385:
4358:
4272:
4180:
4086:
3934:
3663:
3415:
3224:
3220:
3193:
3189:
3168:
3164:
3137:
3133:
3104:
3100:
3075:
3071:
3046:
3042:
2997:
2993:
2962:
2958:
2927:
2923:
2887:(1): 27–35.
2884:
2880:
2849:
2845:
2808:
2804:
2771:
2767:
2742:
2738:
2711:
2707:
2686:
2682:
2647:
2612:
2566:
2562:
2522:
2518:
2504:
2461:
2455:
2444:
2427:
2423:
2413:
2376:
2372:
2362:
2329:
2325:
2318:
2283:
2279:
2269:
2242:
2238:
2225:
2180:
2176:
2166:
2139:
2135:
2125:
2090:
2086:
2076:
2049:
2045:
2032:
2005:
2001:
1991:
1964:
1960:
1950:
1933:
1929:
1919:
1886:
1882:
1876:
1862:
1825:
1821:
1771:
1767:
1721:
1717:
1707:
1680:
1676:
1666:
1631:
1628:Biochemistry
1627:
1617:
1592:
1588:
1582:
1547:
1543:
1533:
1500:
1496:
1490:
1463:
1459:
1449:
1440:
1431:
1422:
1413:
1357:plasma cells
1354:
1338:
1334:chemotherapy
1323:
1259:
1256:Inflammation
1247:
1236:
1225:
1216:plasma cells
1213:
1202:cytoskeletal
1173:proteoglycan
1162:
1154:
1153:
1076:
1054:NP_001006947
1051:
1025:
1003:NM_001006946
1000:
976:
957:
931:
912:
886:
867:
847:
842:
662:cell surface
480:cumulus cell
430:skin of limb
392:
385:
112:External IDs
67:
6286:Vitronectin
6281:Uteroglobin
6271:Transcortin
6244:Glycophorin
6214:Osteonectin
6199:Lactoferrin
5924:Orosomucoid
5914:Haptoglobin
5404:plasma cell
5387:CD23/FcεRII
2774:: 167–176.
2046:Circulation
1595:: 729–777.
1351:Application
1278:endothelium
1270:neutrophils
1268:(including
1209:tat protein
1193:cell-matrix
647:Golgi lumen
442:skin of arm
434:skin of leg
250:20,225,433
237:20,200,797
90:Identifiers
6301:Categories
6114:Syndecan 1
5359:CD10/CALLA
5355:Pre-B cell
5331:by lineage
3298:(see also
2479:0471142956
1408:, May 2017
1387:, May 2017
1363:References
1266:leukocytes
1250:transcript
1243:heparanase
1155:Syndecan 1
396:(ortholog)
351:8,843,715
338:8,821,323
133:HomoloGene
6224:Protein S
6219:Protein C
6194:Hemopexin
6184:Clusterin
6096:Keratocan
5721:Stem cell
5512:CD56/NCAM
2511:Pinkus GS
2379:(1): 57.
1304:-induced
1222:Structure
1079:NP_035649
1058:NP_002988
1028:NM_011519
1007:NM_002997
833:Orthologs
141:GeneCards
6043:Brevican
6038:Neurocan
6033:Aggrecan
6011:Perlecan
6006:Testican
5984:Versican
5979:Biglycan
5939:Ovomucin
5382:CD21/CR2
5370:mature:
5338:Lymphoid
3292:Proteins
3249:30155082
3165:Oncogene
3043:Genomics
2833:43270934
2796:29216939
2695:12144130
2674:10506830
2593:17714757
2541:14983940
2496:19511070
2488:18770841
2436:16739330
2405:28270211
2354:19929711
2346:23289672
2310:25945286
2261:16985046
2217:28350804
2177:PLOS ONE
2158:24078687
2117:20008145
2068:17242279
2024:17805240
1983:19342678
1942:11923257
1911:38757296
1903:28453867
1854:23504321
1798:16982797
1746:13944019
1738:27365088
1699:15220342
1658:16156648
1609:10872465
1574:16948257
1566:12665470
1525:43270934
1404:–
1383:–
1239:lacritin
1177:syndecan
1127:Wikidata
812:Sources:
657:membrane
6091:Lumican
5974:Decorin
5771:Protein
5633:CFU-Meg
5567:Myeloid
5499:NK cell
5100:301–350
4894:251–300
4846:CD240CE
4643:201–250
4327:151–200
4050:101–150
3241:9050911
3212:8889548
3177:8570206
3156:8163535
3121:8125298
3092:8118875
3063:7959737
3034:7690138
3002:Bibcode
2981:7592967
2946:7592855
2911:2519615
2868:2324102
2825:2173154
2788:1664683
2759:1644217
2730:1339431
2639:1442271
2584:3419754
2396:5341174
2301:4397989
2208:5369774
2185:Bibcode
2108:2797877
1845:3636894
1789:1666580
1649:2546870
1517:2173154
1482:2324102
1406:Ensembl
1385:Ensembl
1343:cells.
1302:colitis
1159:protein
945:UniProt
900:Ensembl
839:Species
818:QuickGO
512:condyle
371:pattern
129:1349162
97:Aliases
6164:Avidin
5843:MUC5AC
5576:CFU-GM
5430:T cell
5347:B cell
5107:CD300A
5066:CDw293
4851:CD240D
4712:CD213a
4690:CDw210
4655:CD202b
4629:CDw199
4624:CDw198
4278:CD140b
3710:51–100
3247:
3239:
3210:
3175:
3154:
3119:
3090:
3061:
3032:
3022:
2979:
2944:
2909:
2902:361422
2899:
2866:
2831:
2823:
2794:
2786:
2757:
2728:
2693:
2672:
2662:
2637:
2627:
2591:
2581:
2539:
2494:
2486:
2476:
2434:
2403:
2393:
2352:
2344:
2308:
2298:
2259:
2215:
2205:
2156:
2115:
2105:
2066:
2022:
1981:
1940:
1909:
1901:
1852:
1842:
1796:
1786:
1744:
1736:
1697:
1656:
1646:
1607:
1572:
1564:
1523:
1515:
1480:
1286:kidney
1262:ICAM-1
1200:, and
1113:search
1111:PubMed
978:P18828
959:P18827
855:Entrez
542:BioGPS
229:2p24.1
121:186355
6127:Other
6058:CSPG5
6053:CSPG4
5907:Other
5898:MUC20
5893:MUC19
5888:MUC17
5883:MUC16
5878:MUC15
5873:MUC13
5868:MUC12
5848:MUC5B
5833:MUC3B
5828:MUC3A
5813:CD164
5800:Mucin
5669:CFU-E
5589:CD11c
5413:CD138
5392:CD127
5364:CD79A
5287:CD350
5282:CD349
5277:CD344
5272:CD340
5267:CD339
5262:CD338
5257:CD337
5252:CD336
5247:CD335
5242:CD334
5237:CD333
5232:CD332
5227:CD331
5222:CD329
5217:CD328
5212:CD327
5207:CD326
5202:CD325
5197:CD324
5192:CD322
5187:CD321
5182:CD320
5177:CD318
5172:CD317
5167:CD316
5162:CD315
5157:CD314
5152:CD312
5147:CD309
5142:CD307
5137:CD306
5132:CD305
5127:CD304
5122:CD303
5117:CD302
5112:CD301
5091:CD299
5086:CD298
5081:CD297
5076:CD295
5071:CD294
5061:CD292
5056:CD290
5051:CD289
5046:CD288
5041:CD286
5036:CD284
5031:CD283
5026:CD282
5021:CD281
5016:CD280
5011:CD279
5006:CD278
5001:CD276
4996:CD275
4991:CD274
4986:CD273
4981:CD272
4976:CD271
4971:CD269
4966:CD268
4961:CD267
4956:CD266
4951:CD265
4946:CD264
4941:CD263
4936:CD262
4931:CD261
4926:CD258
4921:CD257
4916:CD256
4911:CD254
4906:CD253
4901:CD252
4885:CD249
4880:CD248
4876:CD247
4871:CD246
4866:CD244
4861:CD243
4856:CD241
4841:CD239
4836:CD238
4831:CD236
4814:CD235
4809:CD234
4804:CD233
4799:CD230
4794:CD229
4789:CD228
4784:CD227
4779:CD226
4774:CD225
4769:CD224
4764:CD223
4759:CD222
4754:CD221
4749:CD220
4734:CD218
4729:CD217
4707:CD212
4685:CD209
4680:CD208
4675:CD207
4670:CD206
4665:CD205
4660:CD204
4650:CD201
4634:CD200
4619:CD197
4614:CD196
4609:CD195
4604:CD194
4599:CD193
4594:CD192
4589:CD191
4584:CD186
4579:CD185
4574:CD184
4569:CD183
4564:CD182
4559:CD181
4554:CD180
4537:CD179
4532:CD178
4527:CD177
4522:CD174
4500:CD172
4495:CD171
4490:CD170
4485:CD169
4480:CD168
4463:CD167
4458:CD166
4453:CD164
4448:CD163
4443:CD162
4438:CD161
4433:CD160
4416:CD159
4386:CD158
4381:CD157
4359:CD156
4354:CD155
4349:CD154
4344:CD153
4339:CD152
4334:CD151
4318:CD150
4313:CD148
4308:CD147
4303:CD146
4298:CD144
4293:CD143
4288:CD142
4283:CD141
4273:CD138
4268:CD137
4263:CD136
4258:CD135
4253:CD134
4248:CD133
4243:CD132
4238:CD131
4233:CD130
4228:CD129
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