906:
301:
Normal cellular functions have not been determined for any of the synuclein proteins. Some data suggest a role in the regulation of membrane stability and/or turnover. Mutations in alpha-synuclein are associated with early-onset familial
Parkinson's disease and the protein aggregates abnormally in
137:
947:
704:
93:
81:
976:
61:
646:
629:
940:
697:
986:
933:
157:
690:
407:
630:"Synucleins are expressed in the majority of breast and ovarian carcinomas and in preneoplastic lesions of the ovary"
460:"An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of Ξ±-synuclein"
971:
806:
311:
966:
836:
676:
227:. Interest in the synuclein family began when alpha-synuclein was found to be mutated in several families with
145:
981:
826:
303:
231:
228:
200:
141:
249:, although they have some conserved structural similarity with plant 'late-embryo-abundant' proteins.
717:
74:
811:
192:
579:
536:
599:"Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing"
651:
610:
571:
528:
489:
440:
390:
241:
lipid-binding motif with similarity to the class-A2 lipid-binding domains of the exchangeable
132:
917:
913:
905:
641:
563:
520:
479:
471:
432:
380:
370:
124:
743:
733:
326:
281:
253:
242:
224:
216:
791:
774:
738:
628:
Bruening W, Giasson BI, Klein-Szanto AJ, Lee VM, Trojanowski JQ, Godwin AK (May 2000).
484:
459:
419:
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, et al. (1997).
267:
220:
86:
672:
421:"Mutation in the alpha-synuclein gene identified in families with Parkinson's disease"
385:
358:
960:
875:
779:
598:
315:
181:
66:
540:
375:
42:
841:
831:
583:
204:
120:
436:
98:
475:
289:
275:
261:
54:
846:
821:
682:
330:
238:
177:
507:
Mezey E, Dehejia A, Harta G, Papp MI, Polymeropoulos MH, Brownstein MJ (1998).
863:
858:
246:
647:
10.1002/(SICI)1097-0142(20000501)88:9<2154::AID-CNCR23>3.0.CO;2-9
307:
655:
575:
493:
394:
614:
532:
444:
70:
853:
764:
554:
Goedert M (July 2001). "Alpha-synuclein and neurodegenerative diseases".
509:"Alpha synuclein in neurodegenerative disorders: murderer or accomplice?"
284:
270:
256:
173:
49:
880:
713:
524:
196:
408:
SYNUCLEIN | Definition of SYNUCLEIN by Oxford
Dictionary on Lexico.com
801:
769:
567:
152:
508:
420:
195:
of the words "synapse" and "nucleus", as it was first found in the
885:
796:
759:
185:
868:
816:
786:
597:
Ji H, Liu YE, Jia T, Wang M, Liu J, Xiao G, et al. (1997).
334:
114:
37:
686:
921:
215:
The synuclein family includes three known proteins:
752:
724:
151:
131:
113:
108:
92:
80:
60:
48:
36:
28:
23:
18:
245:. Synuclein family members are not found outside
237:All synucleins have in common a highly conserved
314:. The gamma-synuclein protein's expression in
352:
350:
941:
698:
8:
948:
934:
705:
691:
683:
105:
675:at the U.S. National Library of Medicine
645:
483:
384:
374:
346:
15:
322:Human proteins containing this domain
7:
902:
900:
318:is a marker for tumor progression.
920:. You can help Knowledge (XXG) by
14:
904:
376:10.1186/gb-2001-3-1-reviews3002
1:
437:10.1126/science.276.5321.2045
109:Available protein structures:
977:Peripheral membrane proteins
476:10.1016/j.celrep.2021.109189
1003:
899:
312:neurodegenerative diseases
807:Brain natriuretic peptide
180:, primarily expressed in
104:
837:Olfactory marker protein
677:Medical Subject Headings
172:are a family of soluble
827:Neuronal calcium sensor
987:Membrane protein stubs
916:βrelated article is a
718:nerve tissue protein
201:electromotor nucleus
812:Nerve growth factor
304:Parkinson's disease
232:Parkinson's disease
556:Nat. Rev. Neurosci
525:10.1038/nm0798-755
369:(1): REVIEWS3002.
357:George JM (2002).
229:autosomal dominant
929:
928:
894:
893:
308:Lewy body disease
167:
166:
163:
162:
158:structure summary
994:
972:Protein families
950:
943:
936:
914:membrane protein
908:
901:
707:
700:
693:
684:
660:
659:
649:
625:
619:
618:
594:
588:
587:
568:10.1038/35081564
551:
545:
544:
504:
498:
497:
487:
455:
449:
448:
431:(5321): 2045β7.
416:
410:
405:
399:
398:
388:
378:
359:"The synucleins"
354:
106:
16:
1002:
1001:
997:
996:
995:
993:
992:
991:
967:Protein domains
957:
956:
955:
954:
897:
895:
890:
748:
744:Gamma-synuclein
734:Alpha-synuclein
720:
711:
669:
664:
663:
627:
626:
622:
596:
595:
591:
553:
552:
548:
506:
505:
501:
458:Kara E (2021).
457:
456:
452:
418:
417:
413:
406:
402:
356:
355:
348:
343:
324:
299:
282:Gamma-synuclein
254:Alpha-synuclein
243:apolipoproteins
225:gamma-synuclein
217:alpha-synuclein
213:
184:and in certain
82:OPM superfamily
12:
11:
5:
1000:
998:
990:
989:
984:
982:Neuropathology
979:
974:
969:
959:
958:
953:
952:
945:
938:
930:
927:
926:
909:
892:
891:
889:
888:
883:
878:
873:
872:
871:
866:
861:
851:
850:
849:
839:
834:
829:
824:
819:
814:
809:
804:
799:
794:
792:Gap-43 protein
789:
784:
783:
782:
777:
775:Chromogranin A
767:
762:
756:
754:
750:
749:
747:
746:
741:
739:Beta-synuclein
736:
730:
728:
722:
721:
712:
710:
709:
702:
695:
687:
681:
680:
668:
667:External links
665:
662:
661:
640:(9): 2154β63.
620:
589:
562:(7): 492β501.
546:
499:
470:(10): 109189.
450:
411:
400:
345:
344:
342:
339:
323:
320:
298:
295:
294:
293:
279:
268:Beta-synuclein
265:
221:beta-synuclein
212:
211:Family members
209:
191:The name is a
165:
164:
161:
160:
155:
149:
148:
135:
129:
128:
118:
111:
110:
102:
101:
96:
90:
89:
84:
78:
77:
64:
58:
57:
52:
46:
45:
40:
34:
33:
30:
26:
25:
21:
20:
13:
10:
9:
6:
4:
3:
2:
999:
988:
985:
983:
980:
978:
975:
973:
970:
968:
965:
964:
962:
951:
946:
944:
939:
937:
932:
931:
925:
923:
919:
915:
910:
907:
903:
898:
887:
884:
882:
879:
877:
876:Synaptophysin
874:
870:
867:
865:
862:
860:
857:
856:
855:
852:
848:
845:
844:
843:
840:
838:
835:
833:
830:
828:
825:
823:
820:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
781:
778:
776:
773:
772:
771:
768:
766:
763:
761:
758:
757:
755:
751:
745:
742:
740:
737:
735:
732:
731:
729:
727:
723:
719:
715:
708:
703:
701:
696:
694:
689:
688:
685:
678:
674:
671:
670:
666:
657:
653:
648:
643:
639:
635:
631:
624:
621:
616:
612:
609:(4): 759β64.
608:
604:
600:
593:
590:
585:
581:
577:
573:
569:
565:
561:
557:
550:
547:
542:
538:
534:
530:
526:
522:
518:
514:
510:
503:
500:
495:
491:
486:
481:
477:
473:
469:
465:
461:
454:
451:
446:
442:
438:
434:
430:
426:
422:
415:
412:
409:
404:
401:
396:
392:
387:
382:
377:
372:
368:
364:
360:
353:
351:
347:
340:
338:
336:
332:
328:
321:
319:
317:
316:breast tumors
313:
309:
305:
296:
292:
291:
286:
283:
280:
278:
277:
272:
269:
266:
264:
263:
258:
255:
252:
251:
250:
248:
244:
240:
239:alpha-helical
235:
233:
230:
226:
222:
218:
210:
208:
206:
202:
198:
194:
189:
187:
183:
182:neural tissue
179:
175:
171:
159:
156:
154:
150:
147:
143:
139:
136:
134:
130:
126:
122:
119:
116:
112:
107:
103:
100:
97:
95:
91:
88:
85:
83:
79:
76:
72:
68:
65:
63:
59:
56:
53:
51:
47:
44:
41:
39:
35:
31:
27:
22:
17:
922:expanding it
911:
896:
842:S100 protein
832:Neuropeptide
725:
637:
633:
623:
606:
602:
592:
559:
555:
549:
519:(7): 755β7.
516:
512:
502:
467:
464:Cell Reports
463:
453:
428:
424:
414:
403:
366:
362:
325:
310:, and other
300:
288:
274:
260:
236:
214:
205:electric ray
190:
169:
168:
847:Calgranulin
822:Neurogranin
363:Genome Biol
247:vertebrates
178:vertebrates
94:OPM protein
24:Identifiers
961:Categories
673:Synucleins
603:Cancer Res
341:References
176:common to
170:Synucleins
121:structures
726:Synuclein
290:IPR002462
276:IPR002461
262:IPR002460
55:IPR001058
32:Synuclein
19:Synuclein
854:Synapsin
765:Chimerin
656:10813729
576:11433374
541:46196799
494:34107263
395:11806835
297:Function
285:InterPro
271:InterPro
257:InterPro
197:synapses
174:proteins
138:RCSB PDB
50:InterPro
881:Tubulin
714:Protein
615:9044857
584:2792701
533:9662355
513:Nat Med
485:8207177
445:9197268
425:Science
333:;
329:;
287::
273::
259::
203:of the
199:in the
43:PF01387
802:Myelin
770:Granin
679:(MeSH)
654:
634:Cancer
613:
582:
574:
539:
531:
492:
482:
443:
393:
386:150459
383:
223:, and
186:tumors
153:PDBsum
127:
117:
75:SUPFAM
29:Symbol
912:This
886:GPM6A
797:GLUT3
760:Agrin
753:Other
580:S2CID
537:S2CID
193:blend
71:SCOPe
62:SCOP2
918:stub
817:SCG5
787:FMR1
652:PMID
611:PMID
572:PMID
529:PMID
490:PMID
441:PMID
391:PMID
335:SNCG
331:SNCB
327:SNCA
146:PDBj
142:PDBe
125:ECOD
115:Pfam
99:1xq8
67:1xq8
38:Pfam
642:doi
564:doi
521:doi
480:PMC
472:doi
433:doi
429:276
381:PMC
371:doi
133:PDB
87:150
963::
716::
650:.
638:88
636:.
632:.
607:57
605:.
601:.
578:.
570:.
558:.
535:.
527:.
515:.
511:.
488:.
478:.
468:35
466:.
462:.
439:.
427:.
423:.
389:.
379:.
365:.
361:.
349:^
337:;
306:,
234:.
219:,
207:.
188:.
144:;
140:;
123:/
73:/
69:/
949:e
942:t
935:v
924:.
869:3
864:2
859:1
780:B
706:e
699:t
692:v
658:.
644::
617:.
586:.
566::
560:2
543:.
523::
517:4
496:.
474::
447:.
435::
397:.
373::
367:3
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