242:
219:
116:
141:
493:
248:
147:
1627:
1014:
Cavin-2 is required for blood vessel formation (angiogenesis) in humans and zebrafish and required also for the endothelial cell proliferation, migration and invasion in humans. Cavin-2 plays an important role in endothelial cell maintenance by regulating eNOS activity. Cavin-2 controls the
1499:
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides".
1165:
Gustincich S, Vatta P, Goruppi S, Wolf M, Saccone S, Della Valle G, et al. (April 1999). "The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein".
1070:. Metastasis suppressor role of SDPR may go beyond breast cancer since tumor samples from bladder, colorectal, lung, pancreatic, and ovarian cancers as well as sarcomas also exhibited loss of SDPR expression.
1537:
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, et al. (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".
1575:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
255:
154:
706:
687:
77:
1696:
1060:
1672:
1147:
1032:
1201:
Gustincich S, Schneider C (September 1993). "Serum deprivation response gene is induced by serum starvation but not by contact inhibition".
1129:
1691:
906:
241:
913:
218:
1231:
1116:
1095:
1059:
studies utilizing breast cancer cell lines. SDPR may elicit its metastasis suppressor function by directly interacting with
1112:
140:
115:
1419:
Cross SH, Charlton JA, Nan X, Bird AP (March 1994). "Purification of CpG islands using a methylated DNA binding column".
1091:
1063:
and limiting its pro-survival role. Moreover, it is suggested that SDPR is silenced during breast cancer progression by
57:
254:
153:
1036:
247:
146:
1665:
751:
65:
1378:"Purification and characterization of a major phosphatidylserine-binding phosphoprotein from human platelets"
732:
1312:
Ozturk S, Papageorgis P, Wong CK, Lambert AW, Abdolmaleky HM, Thiagalingam A, et al. (January 2016).
1256:"Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis"
1658:
1584:
1325:
129:
44:
1064:
1608:
1563:
1525:
1444:
89:
889:
868:
842:
821:
1600:
1555:
1517:
1487:
1436:
1407:
1353:
1287:
1210:
1183:
1040:
37:
1592:
1547:
1509:
1477:
1469:
1428:
1397:
1389:
1343:
1333:
1277:
1267:
1175:
1003:
492:
334:
265:
209:
164:
85:
1067:
1020:
995:
309:
1254:
Boopathy GT, Kulkarni M, Ho SY, Boey A, Chua EW, Barathi VA, et al. (October 2017).
1588:
1329:
1642:
1482:
1457:
1402:
1377:
1348:
1313:
1282:
1255:
48:, PS-p68, SDR, cavin-2, SDPR, serum deprivation response, caveolae associated protein 2
621:
605:
600:
595:
590:
585:
580:
575:
570:
554:
549:
544:
539:
534:
1685:
999:
521:
1567:
1529:
1448:
1019:
in human endothelial cells by controlling the activity and stability of the protein
1638:
1612:
1314:"SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis"
1232:"Entrez Gene: SDPR serum deprivation response (phosphatidylserine binding protein)"
1016:
991:
327:
106:
69:
93:
1152:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1134:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1318:
Proceedings of the
National Academy of Sciences of the United States of America
410:
1052:
226:
123:
73:
1338:
1272:
1056:
651:
470:
348:
293:
280:
192:
179:
81:
1604:
1559:
1521:
1357:
1291:
1187:
1179:
1491:
1473:
1440:
1411:
1214:
953:
948:
937:
796:
777:
1596:
1432:
1002:-starved cells. This protein has also been shown to be a substrate for
987:. Cavin-2 is highly expressed in a variety of human endothelial cells.
977:
763:
718:
1393:
921:
673:
1626:
1551:
1513:
636:
632:
1634:
984:
61:
1456:
Mineo C, Ying YS, Chapline C, Jaken S, Anderson RG (May 1998).
501:
1031:
Cavin-2 is highly secreted from human endothelial cells (
1376:
Burgener R, Wolf M, Ganz T, Baggiolini M (August 1990).
317:
1646:
482:
882:
861:
835:
814:
1108:
1106:
1104:
1087:
1085:
1083:
264:
163:
1458:"Targeting of protein kinase Calpha to caveolae"
1249:
1247:
1245:
1243:
1241:
16:Protein-coding gene in the species Homo sapiens
1307:
1305:
1303:
1301:
1113:GRCm38: Ensembl release 89: ENSMUSG00000045954
1666:
8:
1092:GRCh38: Ensembl release 89: ENSG00000168497
1673:
1659:
647:
517:
305:
204:
101:
1481:
1401:
1347:
1337:
1281:
1271:
1226:
1224:
1021:endothelial nitric-oxide synthase (eNOS)
1079:
18:
269:
230:
225:
168:
127:
122:
7:
1623:
1621:
1043:and is required for EMP biogenesis.
990:This gene has a calcium-independent
437:vestibular membrane of cochlear duct
1260:The Journal of Biological Chemistry
970:Serum deprivation-response protein
879:
858:
832:
811:
787:
768:
742:
723:
697:
678:
487:
405:
343:
322:
14:
1203:Cell Growth & Differentiation
980:that in humans is encoded by the
1625:
491:
253:
246:
240:
217:
152:
145:
139:
114:
502:More reference expression data
471:More reference expression data
1:
1697:Human chromosome 2 gene stubs
1035:), they are secreted through
238:
137:
1645:. You can help Knowledge by
1692:Genes on human chromosome 2
1462:The Journal of Cell Biology
375:superficial temporal artery
1713:
1620:
1051:SDPR is shown to act as a
1037:endothelial microparticles
622:plasma membrane tubulation
535:phosphatidylserine binding
453:tunica adventitia of aorta
1148:"Mouse PubMed Reference:"
1130:"Human PubMed Reference:"
952:
947:
943:
936:
920:
907:Chr 2: 191.83 – 191.85 Mb
901:
886:
865:
854:
839:
818:
807:
794:
790:
775:
771:
762:
749:
745:
730:
726:
717:
704:
700:
685:
681:
672:
657:
650:
646:
630:
520:
516:
499:
490:
481:
468:
417:
408:
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
550:protein kinase C binding
1382:The Biochemical Journal
1339:10.1073/pnas.1514663113
1273:10.1074/jbc.M117.794743
1006:(PKC) phosphorylation.
994:-binding protein whose
914:Chr 1: 51.33 – 51.34 Mb
379:upper lobe of left lung
1180:10.1006/geno.1998.5733
441:atrioventricular valve
1474:10.1083/jcb.141.3.601
1047:Clinical significance
1540:Nature Biotechnology
1502:Nature Biotechnology
545:phospholipid binding
449:white adipose tissue
232:Chromosome 1 (mouse)
130:Chromosome 2 (human)
1597:10.1038/nature04209
1589:2005Natur.437.1173R
1330:2016PNAS..113..638O
1266:(43): 17760–17776.
1633:This article on a
1433:10.1038/ng0394-236
752:ENSMUSG00000045954
615:Biological process
606:actin cytoskeleton
564:Cellular component
528:Molecular function
371:upper lobe of lung
363:lower lobe of lung
94:CAVIN2 - orthologs
1654:
1653:
1394:10.1042/bj2690729
1017:nitric oxide (NO)
963:
962:
959:
958:
932:
931:
897:
896:
876:
875:
850:
849:
829:
828:
803:
802:
784:
783:
758:
757:
739:
738:
713:
712:
694:
693:
642:
641:
512:
511:
508:
507:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
1704:
1675:
1668:
1661:
1629:
1622:
1616:
1583:(7062): 1173–8.
1571:
1533:
1495:
1485:
1452:
1415:
1405:
1362:
1361:
1351:
1341:
1309:
1296:
1295:
1285:
1275:
1251:
1236:
1235:
1228:
1219:
1218:
1198:
1192:
1191:
1162:
1156:
1155:
1144:
1138:
1137:
1126:
1120:
1110:
1099:
1089:
1004:protein kinase C
945:
944:
916:
909:
892:
880:
871:
859:
855:RefSeq (protein)
845:
833:
824:
812:
788:
769:
743:
724:
698:
679:
648:
518:
504:
495:
488:
473:
413:
411:Top expressed in
406:
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1712:
1711:
1707:
1706:
1705:
1703:
1702:
1701:
1682:
1681:
1680:
1679:
1619:
1574:
1536:
1498:
1455:
1421:Nature Genetics
1418:
1375:
1371:
1369:Further reading
1366:
1365:
1311:
1310:
1299:
1253:
1252:
1239:
1230:
1229:
1222:
1200:
1199:
1195:
1164:
1163:
1159:
1146:
1145:
1141:
1128:
1127:
1123:
1111:
1102:
1090:
1081:
1076:
1068:DNA methylation
1049:
1039:(EMPs) but not
1029:
1012:
954:View/Edit Mouse
949:View/Edit Human
912:
905:
902:Location (UCSC)
888:
867:
841:
820:
733:ENSG00000168497
626:
610:
601:plasma membrane
559:
540:protein binding
500:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
425:right lung lobe
423:
409:
398:
393:
389:
385:
383:parietal pleura
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1710:
1708:
1700:
1699:
1694:
1684:
1683:
1678:
1677:
1670:
1663:
1655:
1652:
1651:
1630:
1618:
1617:
1572:
1552:10.1038/nbt971
1534:
1514:10.1038/nbt810
1496:
1453:
1416:
1372:
1370:
1367:
1364:
1363:
1297:
1237:
1220:
1193:
1157:
1139:
1121:
1100:
1078:
1077:
1075:
1072:
1055:suppressor by
1048:
1045:
1028:
1025:
1015:generation of
1011:
1008:
961:
960:
957:
956:
951:
941:
940:
934:
933:
930:
929:
927:
925:
918:
917:
910:
903:
899:
898:
895:
894:
884:
883:
877:
874:
873:
863:
862:
856:
852:
851:
848:
847:
837:
836:
830:
827:
826:
816:
815:
809:
805:
804:
801:
800:
792:
791:
785:
782:
781:
773:
772:
766:
760:
759:
756:
755:
747:
746:
740:
737:
736:
728:
727:
721:
715:
714:
711:
710:
702:
701:
695:
692:
691:
683:
682:
676:
670:
669:
664:
659:
655:
654:
644:
643:
640:
639:
628:
627:
625:
624:
618:
616:
612:
611:
609:
608:
603:
598:
593:
588:
583:
578:
573:
567:
565:
561:
560:
558:
557:
552:
547:
542:
537:
531:
529:
525:
524:
514:
513:
510:
509:
506:
505:
497:
496:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
433:left lung lobe
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1709:
1698:
1695:
1693:
1690:
1689:
1687:
1676:
1671:
1669:
1664:
1662:
1657:
1656:
1650:
1648:
1644:
1640:
1636:
1631:
1628:
1624:
1614:
1610:
1606:
1602:
1598:
1594:
1590:
1586:
1582:
1578:
1573:
1569:
1565:
1561:
1557:
1553:
1549:
1546:(6): 707–16.
1545:
1541:
1535:
1531:
1527:
1523:
1519:
1515:
1511:
1507:
1503:
1497:
1493:
1489:
1484:
1479:
1475:
1471:
1468:(3): 601–10.
1467:
1463:
1459:
1454:
1450:
1446:
1442:
1438:
1434:
1430:
1427:(3): 236–44.
1426:
1422:
1417:
1413:
1409:
1404:
1399:
1395:
1391:
1388:(3): 729–34.
1387:
1383:
1379:
1374:
1373:
1368:
1359:
1355:
1350:
1345:
1340:
1335:
1331:
1327:
1324:(3): 638–43.
1323:
1319:
1315:
1308:
1306:
1304:
1302:
1298:
1293:
1289:
1284:
1279:
1274:
1269:
1265:
1261:
1257:
1250:
1248:
1246:
1244:
1242:
1238:
1233:
1227:
1225:
1221:
1216:
1212:
1209:(9): 753–60.
1208:
1204:
1197:
1194:
1189:
1185:
1181:
1177:
1173:
1169:
1161:
1158:
1153:
1149:
1143:
1140:
1135:
1131:
1125:
1122:
1118:
1114:
1109:
1107:
1105:
1101:
1097:
1093:
1088:
1086:
1084:
1080:
1073:
1071:
1069:
1066:
1062:
1058:
1054:
1046:
1044:
1042:
1038:
1034:
1026:
1024:
1022:
1018:
1009:
1007:
1005:
1001:
998:increases in
997:
993:
988:
986:
983:
979:
975:
971:
967:
955:
950:
946:
942:
939:
935:
928:
926:
923:
919:
915:
911:
908:
904:
900:
893:
891:
885:
881:
878:
872:
870:
864:
860:
857:
853:
846:
844:
838:
834:
831:
825:
823:
817:
813:
810:
808:RefSeq (mRNA)
806:
799:
798:
793:
789:
786:
780:
779:
774:
770:
767:
765:
761:
754:
753:
748:
744:
741:
735:
734:
729:
725:
722:
720:
716:
709:
708:
703:
699:
696:
690:
689:
684:
680:
677:
675:
671:
668:
665:
663:
660:
656:
653:
649:
645:
638:
634:
629:
623:
620:
619:
617:
614:
613:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
577:
576:membrane raft
574:
572:
569:
568:
566:
563:
562:
556:
555:lipid binding
553:
551:
548:
546:
543:
541:
538:
536:
533:
532:
530:
527:
526:
523:
522:Gene ontology
519:
515:
503:
498:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
387:abdominal fat
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:1|1 C1.1
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1647:expanding it
1639:chromosome 2
1632:
1580:
1576:
1543:
1539:
1508:(5): 566–9.
1505:
1501:
1465:
1461:
1424:
1420:
1385:
1381:
1321:
1317:
1263:
1259:
1206:
1202:
1196:
1174:(1): 120–9.
1171:
1167:
1160:
1151:
1142:
1133:
1124:
1050:
1030:
1013:
992:phospholipid
989:
981:
973:
969:
965:
964:
887:
866:
840:
819:
795:
776:
750:
731:
705:
686:
666:
661:
457:carotid body
333:
326:
191:191,847,088
178:191,834,310
53:External IDs
596:nucleoplasm
395:pericardium
391:gallbladder
292:51,342,119
279:51,328,285
31:Identifiers
1686:Categories
1119:, May 2017
1098:, May 2017
1074:References
1053:metastasis
996:expression
421:right lung
367:right lung
337:(ortholog)
74:HomoloGene
1637:on human
1057:xenograft
1027:Secretion
890:NP_620080
869:NP_004648
843:NM_138741
822:NM_004657
652:Orthologs
571:cytoplasm
429:left lung
82:GeneCards
1605:16189514
1568:27764390
1560:15146197
1530:23783563
1522:12665801
1449:12847618
1358:26739564
1292:28912276
1188:10191091
1168:Genomics
1115:–
1094:–
1065:promoter
1041:exosomes
1010:Function
938:Wikidata
631:Sources:
586:membrane
359:monocyte
1613:4427026
1585:Bibcode
1492:9566962
1483:2132740
1441:8012384
1412:2390065
1403:1131648
1349:4725521
1326:Bibcode
1283:5663877
1215:8241023
1117:Ensembl
1096:Ensembl
978:protein
976:) is a
966:Cavin-2
764:UniProt
719:Ensembl
658:Species
637:QuickGO
591:caveola
581:cytosol
312:pattern
38:Aliases
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1577:Nature
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924:search
922:PubMed
797:Q63918
778:O95810
674:Entrez
483:BioGPS
445:atrium
170:2q32.3
86:CAVIN2
62:606728
45:CAVIN2
22:CAVIN2
1641:is a
1609:S2CID
1564:S2CID
1526:S2CID
1445:S2CID
1033:HUVEC
1000:serum
707:20324
667:Mouse
662:Human
633:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
70:99513
1643:stub
1635:gene
1601:PMID
1556:PMID
1518:PMID
1488:PMID
1437:PMID
1408:PMID
1354:PMID
1288:PMID
1211:PMID
1184:PMID
985:gene
982:SDPR
974:SDPR
688:8436
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
78:3422
58:OMIM
1593:doi
1581:437
1548:doi
1510:doi
1478:PMC
1470:doi
1466:141
1429:doi
1398:PMC
1390:doi
1386:269
1344:PMC
1334:doi
1322:113
1278:PMC
1268:doi
1264:292
1176:doi
1061:ERK
968:or
288:End
187:End
90:OMA
66:MGI
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