1511:. In experiments using the rat basophilic leukemia cell line RBL-2H3 stably transfected with Siglec-8, the inhibitory effect of Siglec-8 ligation on FcεRIα-mediated degranulation and Ca flux was found to be dependent on the intact ITIM. In studies involving transgenic mouse Siglec-8-expressing bone marrow-derived mast cells, co-engagement of Siglec-8 and FcεRIα leads to the inhibition of proximal kinase signaling downstream of FcεRI ligation. However, the inhibitory activity of Siglec-8 extends beyond counteracting FcεRI-mediated mast cell activation in transgenic mice: monoclonal antibody engagement of Siglec-8 reduced mast cell activation, immune cell recruitment, and lung fibrosis in a cigarette smoke-induced model of chronic obstructive pulmonary disease and in a bleomycin-induced model of lung injury. Antibody engagement of Siglec-8 also impeded IL-33-driven mast cell activation and immune cell recruitment. Unlike on eosinophils, antibody engagement of Siglec-8 on human mast cells does not lead to substantial levels of
1588:-sulfotransferase 1 (C6ST-1), express equivalent levels of Siglec-F ligand. These models may shed some light on the regulation of human eosinophil biology by Siglec-8 and the production of natural Siglec-8 ligands in humans. Also like Siglec-8, Siglec-F ligation leads to the apoptosis of eosinophils. However, Siglec-F–induced eosinophil apoptosis is mediated by a mechanism distinct from that employed by Siglec-8, hindering direct comparisons between the mouse and human systems. Siglec-F-induced apoptosis is mediated by caspase activation in mouse eosinophils and does not involve ROS, in contrast to the mechanism reported in Siglec-8–induced apoptosis of human eosinophils. This apoptotic mechanism also does not involve
301:
278:
175:
200:
1560:-acetyl-D-lactosamine, similar but distinct patterns of cellular expression, and similar inhibitory functions. For example, Siglec-F is expressed by eosinophils, like Siglec-8, but is also expressed by alveolar macrophages and has not been detected on mouse mast cells or basophils. This functional convergence of Siglec-8 and Siglec-F has permitted in vivo studies to be performed in mouse models of eosinophil-mediated disorders that may provide information about the human system. In a chicken
1564:(OVA) model of allergic airway inflammation, the Siglec-F knockout mouse exhibits increased lung eosinophilia, enhanced inflammation, delayed resolution, and exacerbated peribronchial fibrosis. Antibody ligation of Siglec-F has also been shown to inhibit eosinophil-mediated intestinal inflammation and airway remodeling in OVA challenge models. The ST3Gal-III enzyme is necessary for the generation of the natural Siglec-F ligand, which remains unknown but is induced by
552:
566:
559:
307:
206:
1190:, binds with high affinity to both Siglec-8 and to a mouse siglec, Siglec-F, which appears to have acquired a similar but not identical function and pattern of expression to human Siglec-8 through convergent evolution (the two siglecs are not orthologous). Rescreening on a more expanded glycan array reconfirmed this finding, but also identified a second closely related ligand in which the
1195:
carbon 6 of galactose as in 6′-sulfo-sialyl Lewis X. Similarly, no other siglecs bind effectively to these Siglec-8 ligands, as demonstrated by selective binding to eosinophils in human blood of a polymer decorated with 6′-sulfo-sialyl Lewis X. The natural ligand or ligands for Siglec-8 have not yet been positively identified, but ongoing studies have determined that there are
2969:
Yokoi H, Choi OH, Hubbard W, Lee HS, Canning BJ, Lee HH, Ryu SD, von Gunten S, Bickel CA, Hudson SA, Macglashan DW, Bochner BS (February 2008). "Inhibition of
FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement".
1539:
Due to its high level of sequence homology with CD33 (Siglec-3), Siglec-8 is grouped within the CD33-related siglec subfamily. This family is composed of a rapidly evolving group of siglecs that share 50–99% sequence identity. Most members of the subfamily also possess conserved cytoplasmic ITIM and
1168:
Two splice variants of Siglec-8 exist. The initially characterized form contains 431 amino acid residues in total, 47 of which comprise an uncharacteristically short cytoplasmic tail compared to most CD33-associated siglecs. Subsequently, a longer form of Siglec-8, initially termed Siglec-8L, that
1116:
or EoL-3 that have been differentiated towards an eosinophil-like lineage. Only low levels are detected on the human mast cell sub-line HMC-1.1; however, the HMC-1.2 cell line, which bears a second KIT mutation (D816V, in addition to the V560G mutation found in both HMC-1.1 and HMC-1.2 cells) that
1194:
is absent (NeuAcα2–3(6-O-sulfo)Galβ1–4GlcNAc, or 6′-sulfated sialyl N-acetyl-D-lactosamine. These interactions are quite specific; no binding could be detected between these siglecs and unsulfated sialyl Lewis X or sialyl Lewis X sulfated at carbon 6 of GlcNAc (6-sulfo-sialyl Lewis X) rather than
3671:
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T,
1471:
are necessary prior to integrin upregulation and ROS production. Cell death induced by Siglec-8 in the presence of IL-33, in contrast, is mediated primarily by a caspase-dependent pathway, and IL-33 is capable of synergizing with IL-5 in potentiating cell death induced by Siglec-8 ligation.
1177:
activity and two C2-type Ig repeat domains in the extracellular region. Given that the longer version is felt to be the normal version, the term Siglec-8 is best used to refer to the 499 amino acid version, while the 431 amino acid version is best referred to as the “short form” of Siglec-8.
1308:
integrin upregulation and conformational activation was elucidated using pharmacologic inhibition of key signaling molecules combined with analyses of cellular events leading to cell death. This signaling pathway is atypical for an ITIM-bearing siglec and involves the activities of a
1111:
Consistent with the concept that Siglec-8 is a late differentiation marker, Siglec-8 has not been detected on the surface of relatively undifferentiated eosinophilic cell lines, such as EoL-1, AML14, AML14.3D10, or K562, the basophilic leukemia cell line KU812, nor on cells such as
50:
1092:. In both eosinophils and mast cells, Siglec-8 is expressed late in development. Siglec-8 transcript and protein are detectable at day 12 during the in vitro differentiation of eosinophils from cord blood precursors, whereas the transcription factor
1276:. IL-5 stimulation also appears to alter the mode of cell death of eosinophils induced by Siglec-8 ligation in that cell death becomes a caspase-independent process. On IL-5-primed eosinophils, antibody ligation of Siglec-8 was found to lead to
1210:
ligand (1-MDa polyacrylamide ribbon decorated with 6′-O-sulfo-3′-sialyl-LacNAc) binds to these cells by about 50%. Indeed, removal of α2,3-linked sialic acid from the cell surface not only enables Siglec-8 to bind ligand in
3056:
Schanin J, Gebremeskel S, Korver W, Falahati R, Butuci M, Haw TJ, Nair PM, Liu G, Hansbro NG, Hansbro PM, Evensen E, Brock EC, Xu A, Wong A, Leung J, Bebbington C, Tomasevic N, Youngblood BA (March 2021).
1572:
in the airway. Loss of this enzyme leads to enhanced allergic eosinophilic airway inflammation. Despite evidence that Siglec-F binds specifically to 6′-sulfo-sialyl Lewis X and 6′-sulfated sialyl
1240:
Consistent with the role of most siglecs and the presence of the intracellular ITIM, Siglec-8 has been found to function as an inhibitory immunoregulatory receptor. Ligation of Siglec-8 induces
1152:
express on their cell surface a protein or proteins that are recognized by polyclonal human Siglec-8-specific antibody, consistent with genetic analyses indicating the existence of a Siglec-8
1169:
contains 499 amino acid residues was identified. This longer form of Siglec-8 shares the same extracellular region but includes a longer cytoplasmic tail with two tyrosine-based motifs (an
1451:
does not alter ROS generation but the ROS inhibitor diphenyleneiodonium inhibits ERK1/2 phosphorylation and cell death, leading to the conclusion that the production of ROS is upstream of
2092:
Yokoi H, Myers A, Matsumoto K, Crocker PR, Saito H, Bochner BS (June 2006). "Alteration and acquisition of
Siglecs during in vitro maturation of CD34+ progenitors into human mast cells".
2229:"Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6'-sulfo-sialyl Lewis X as a preferred glycan ligand"
1777:
Foussias G, Yousef GM, Diamandis EP (November 2000). "Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene".
1519:
upon Siglec-8 antibody ligation on primary human mast cells, suggesting that this pathway remains intact in mast cells but that it is restrained by the interaction of Siglec-8 with
1821:
Kikly KK, Bochner BS, Freeman SD, Tan KB, Gallagher KT, D'alessio KJ, Holmes SD, Abrahamson JA, Erickson-Miller CL, Murdock PR, Tachimoto H, Schleimer RP, White JR (June 2000).
1156:
in this species. However, the 2C4, 2E2, and 7C9 monoclonal antibodies against human Siglec-8 were not found to bind to targets on baboon cells, indicating that these particular
1556:
do not appear to derive from the same ancestral gene (they are paralogous, not orthologous), they share a binding preference for 6′-sulfo-sialyl Lewis X and 6′-sulfated sialyl
314:
213:
1272:
activation. In the presence of IL-5, the loss of mitochondrial membrane integrity is accelerated and the secondary crosslinking antibody is no longer necessary to induce
1064:
and was originally termed SAF-2 (sialoadhesin family 2). At the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney.
3315:"Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13"
1479:
upon antibody ligation on eosinophils and mast cells. This process is dependent on the cytoplasmic ITIM (and not the ITSM), the activities of tyrosine kinases and
1199:-sensitive glycoprotein ligands for Siglec-F in mouse airways that require the activity of the α2,3 sialyltransferase 3 (ST3Gal-III) enzyme for their generation.
1170:
1117:
may induce further differentiation, expresses Siglec-8 at the cell surface. However, based on a small sampling of patients, all eosinophils from patients with
1597:
3735:
1284:
integrin upregulation, conformational activation, and subsequent integrin-mediated adhesion. Disruption of integrin-mediated adhesion with antibodies to
744:
725:
136:
3005:
Korver W, Wong A, Gebremeskel S, Negri GL, Schanin J, Chang K, Leung J, Benet Z, Luu T, Brock EC, Luehrsen K, Xu A, Youngblood BA (January 28, 2022).
2720:
Nutku E, Hudson SA, Bochner BS (October 2005). "Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury".
2809:"Sialic acid-binding immunoglobulin-like lectin 8 (Siglec-8) is an activating receptor mediating β2-integrin-dependent function in human eosinophils"
1924:
Padler-Karavani V, Hurtado-Ziola N, Chang YC, Sonnenburg JL, Ronaghy A, Yu H, Verhagen A, Nizet V, Chen X, Varki N, Varki A, Angata T (March 2014).
3674:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
1456:
1444:
1186:
Potential glycan ligands for Siglec-8 have been screened by glycan array. The glycan NeuAcα2–3(6-O-sulfo)Galβ1–4GlcNAc, also known as 6′-sulfo-
1696:
4043:
1678:
4048:
3518:"Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen"
3007:"The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation"
2277:"Mice deficient in the St3gal3 gene product α2,3 sialyltransferase (ST3Gal-III) exhibit enhanced allergic eosinophilic airway inflammation"
1219:, unmasks Siglec-8) but also impacts Siglec-8 function upon antibody engagement, which itself is not impeded by Siglec-8 interactions with
1300:
integrins act as essential mediators in the Siglec-8 ligation-induced cell death process in eosinophils. The signaling cascade leading to
2679:
Suzukawa M, Koketsu R, Iikura M, Nakae S, Matsumoto K, Nagase H, Saito H, Matsushima K, Ohta K, Yamamoto K, Yamaguchi M (November 2008).
1867:"Large-scale sequencing of the CD33-related Siglec gene cluster in five mammalian species reveals rapid evolution by multiple mechanisms"
1459:
signaling in this pathway. However, in eosinophils that had been primed with IL-5 18–24 h prior to Siglec-8 ligation, the activities of
2919:"Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation"
2488:"Interactions between Siglec-8 and endogenous sialylated cis ligands restrain cell death induction in human eosinophils and mast cells"
300:
960:
1173:
and an immunoreceptor tyrosine-based switch motif ). Both forms of Siglec-8 are found in eosinophils and contain a V-set domain with
3767:
967:
1264:
induced by crosslinking Siglec-8 through the use of an anti-Siglec-8 mAb and a secondary antibody is mediated sequentially through
277:
1760:
3059:"A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation"
1665:
1644:
3887:
199:
174:
1661:
3261:
Zimmermann N, McBride ML, Yamada Y, Hudson SA, Jones C, Cromie KD, Crocker PR, Rothenberg ME, Bochner BS (September 2008).
1487:
rearrangement. Furthermore, it can be exploited to deliver toxins to human eosinophils or mast cells to selectively induce
47:
1988:"Developmental, malignancy-related, and cross-species analysis of eosinophil, mast cell, and basophil siglec-8 expression"
1986:
Hudson SA, Herrmann H, Du J, Cox P, Haddad el-B, Butler B, Crocker PR, Ackerman SJ, Valent P, Bochner BS (December 2011).
1118:
2037:"Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression"
1640:
3953:
1617:
1358:
1129:(CML), all basophils from patients with CEL or CML, and all bone marrow mast cells from patients with indolent systemic
116:
313:
212:
3803:
3464:"Galactose 6-O-sulfotransferases are not required for the generation of Siglec-F ligands in leukocytes or lung tissue"
3628:
Munday J, Kerr S, Ni J, Cornish AL, Zhang JQ, Nicoll G, Floyd H, Mattei MG, Moore P, Liu D, Crocker PR (April 2001).
1354:
3630:"Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor"
306:
205:
1122:
1061:
3831:
3415:"Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model"
1926:"Rapid evolution of binding specificities and expression patterns of inhibitory CD33-related Siglecs in primates"
1609:
1137:
express Siglec-8, providing a potential target for these cells in the context of these hematologic malignancies.
3364:
Song DJ, Cho JY, Lee SY, Miller M, Rosenthal P, Soroosh P, Croft M, Zhang M, Varki A, Broide DH (October 2009).
3726:
3462:
Patnode ML, Cheng CW, Chou CC, Singer MS, Elin MS, Uchimura K, Crocker PR, Khoo KH, Rosen SD (September 2013).
1576:-acetyl-D-lactosamine, in which galactose is sulfated at carbon 6, mice deficient in the two known galactose 6-
1126:
1084:. It has thus garnered attention as a molecule that is uniquely expressed by immune effector cells involved in
789:
124:
2380:"Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice"
1413:
1289:
1265:
770:
1256:, which activates and maintains eosinophils, also exerts a similar potentiating effect on Siglec-8-induced
3818:
3760:
2324:
Guo JP, Brummet ME, Myers AC, Na HJ, Rowland E, Schnaar RL, Zheng T, Zhu Z, Bochner BS (February 2011).
188:
3529:
1878:
103:
3722:
3313:
Cho JY, Song DJ, Pham A, Rosenthal P, Miller M, Dayan S, Doherty TA, Varki A, Broide DH (Nov 2010).
1206:
ligands. Treatment of human eosinophils with sialidase increases the extent to which a high-avidity
4005:
1097:
939:
918:
884:
863:
3366:"Anti-Siglec-F antibody reduces allergen-induced eosinophilic inflammation and airway remodeling"
3211:"Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils"
3137:
2275:
Kiwamoto T, Brummet ME, Wu F, Motari MG, Smith DF, Schnaar RL, Zhu Z, Bochner BS (January 2014).
2117:
2074:
1057:
148:
3575:
Dellon ES, Peterson KA, Murray JA, Falk GW, Gonsalves N, Chehade M, et al. (October 2020).
943:
914:
888:
859:
551:
3703:
3659:
3606:
3557:
3495:
3444:
3395:
3346:
3292:
3240:
3186:
3129:
3088:
3038:
2987:
2948:
2896:
2838:
2786:
2737:
2702:
2661:
2609:
2560:
2519:
2463:
2409:
2355:
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2250:
2204:
2158:
2109:
2066:
2017:
1957:
1906:
1844:
1794:
1742:
1589:
1503:
Siglec-8 antibody engagement has been shown to inhibit FcεRIα-mediated Ca flux and release of
1310:
565:
558:
96:
40:
3157:"Detection and quantitation of eosinophils in the murine respiratory tract by flow cytometry"
2434:"Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells"
1823:"Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils"
144:
4010:
3825:
3753:
3693:
3685:
3649:
3641:
3596:
3588:
3547:
3537:
3485:
3475:
3434:
3426:
3385:
3377:
3336:
3326:
3282:
3274:
3230:
3222:
3176:
3168:
3119:
3078:
3070:
3028:
3018:
2979:
2938:
2930:
2886:
2876:
2828:
2820:
2776:
2768:
2729:
2692:
2651:
2643:
2599:
2591:
2550:
2509:
2499:
2453:
2445:
2399:
2391:
2345:
2337:
2296:
2288:
2240:
2194:
2148:
2101:
2056:
2048:
2007:
1999:
1947:
1937:
1896:
1886:
1834:
1786:
1732:
1504:
1480:
1326:
393:
324:
268:
223:
3263:"Siglec-F antibody administration to mice selectively reduces blood and tissue eosinophils"
2865:"Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro"
4053:
2181:
Bochner BS, Alvarez RA, Mehta P, Bovin NV, Blixt O, White JR, Schnaar RL (February 2005).
1425:
1322:
1134:
368:
2539:"Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis"
1719:
Floyd H, Ni J, Cornish AL, Zeng Z, Liu D, Carter KC, Steel J, Crocker PR (January 2000).
1060:
screening of ESTs from a cDNA library generated from a patient diagnosed with idiopathic
3533:
2757:"Interleukin-5 priming of human eosinophils alters siglec-8 mediated apoptosis pathways"
2514:
2487:
2061:
2036:
1882:
1104:+ precursors, Siglec-8 expression peaks at 4 weeks of differentiation, in parallel with
4000:
3698:
3673:
3654:
3629:
3601:
3576:
3552:
3517:
3490:
3463:
3439:
3414:
3390:
3365:
3341:
3314:
3287:
3262:
3235:
3210:
3181:
3156:
3083:
3058:
3033:
3006:
2943:
2918:
2891:
2864:
2833:
2808:
2781:
2756:
2656:
2631:
2604:
2579:
2458:
2433:
2404:
2379:
2350:
2325:
2301:
2276:
2012:
1987:
1952:
1925:
1569:
1515:. However, enzymatic removal of α2,3-linked sialic acid from the cell surface promotes
1393:
1253:
1187:
2681:"Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophils"
2378:
Suzukawa M, Miller M, Rosenthal P, Cho JY, Doherty TA, Varki A, Broide D (June 2013).
1901:
1866:
659:
654:
638:
633:
617:
612:
607:
4037:
4017:
3795:
3739:
3278:
2326:"Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs"
2105:
2052:
1565:
1432:
1405:
1385:
1245:
594:
3141:
2121:
2078:
128:
3943:
3872:
1613:
1130:
386:
165:
3413:
Song DJ, Cho JY, Miller M, Strangman W, Zhang M, Varki A, Broide DH (April 2009).
1223:
ligands. The precise identities of the glycan ligands to which Siglec-8 binds in
3542:
3516:
Mao H, Kano G, Hudson SA, Brummet M, Zimmermann N, Zhu Z, Bochner BS (Jun 2013).
3226:
152:
3645:
1721:"Siglec-8. A novel eosinophil-specific member of the immunoglobulin superfamily"
1701:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1683:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1616:, a monoclonal antibody targeting SIGLEC8 has been evaluated as a treatment for
1476:
3430:
3074:
2983:
2934:
2824:
2733:
2647:
2595:
2555:
2538:
2504:
2449:
2292:
1871:
Proceedings of the
National Academy of Sciences of the United States of America
469:
3978:
3172:
3023:
2881:
2807:
Carroll DJ, O'Sullivan JA, Nix DB, Cao Y, Tiemeyer M, Bochner BS (June 2018).
2697:
2680:
2003:
1516:
1512:
1488:
1436:
1397:
1377:
1293:
1273:
1261:
1257:
1241:
1202:
There is also evidence that Siglec-8 on eosinophils interacts with sialylated
1149:
1145:
1073:
285:
182:
132:
3381:
3331:
2772:
2395:
2341:
1526:
There are no published data regarding the function of Siglec-8 on basophils.
1033:. This gene is located on chromosome 19q13.4, about 330 kb downstream of the
3813:
3480:
2245:
2228:
2153:
2136:
1891:
1839:
1822:
1561:
1508:
1196:
1100:
peaks at day 4 in this differentiation system. In mast cells generated from
1077:
689:
529:
407:
352:
339:
251:
238:
140:
3707:
3663:
3610:
3561:
3499:
3448:
3399:
3350:
3296:
3244:
3190:
3133:
3092:
3042:
2991:
2952:
2900:
2842:
2790:
2741:
2706:
2665:
2613:
2580:"A novel IL-1 family cytokine, IL-33, potently activates human eosinophils"
2564:
2523:
2467:
2413:
2359:
2310:
2254:
2208:
2199:
2182:
2162:
2113:
2070:
2021:
1961:
1910:
1848:
1798:
1790:
1746:
1045:-related siglec subfamily, a subfamily that has undergone rapid evolution.
3592:
1737:
1720:
1007:
1002:
3958:
3948:
3938:
3922:
3917:
3852:
3847:
3842:
3837:
2035:
Ellis AK, Ackerman SJ, Crawford L, Du J, Bedi R, Denburg JA (June 2010).
1942:
1153:
1141:
1081:
991:
834:
815:
3995:
3912:
3902:
3897:
3892:
3776:
3689:
1269:
1244:
in eosinophils, and, surprisingly, the normally pro-survival cytokines
1157:
1089:
1034:
1023:
801:
756:
3155:
Stevens WW, Kim TS, Pujanauski LM, Hao X, Braciale TJ (October 2007).
2685:
Laboratory
Investigation; A Journal of Technical Methods and Pathology
73:
69:
4022:
3864:
3780:
2432:
O'Sullivan JA, Carroll DJ, Cao Y, Salicru AN, Bochner BS (May 2018).
1389:
1366:
1249:
1207:
1191:
1174:
1105:
1093:
1085:
1038:
975:
711:
3209:
Zhang M, Angata T, Cho JY, Miller M, Broide DH, Varki A (May 2007).
3124:
3107:
1361:
typically associated with ITIM-mediated signaling pathways, such as
3745:
1491:
when Siglec-8 ligation by itself would not be sufficient to do so (
3988:
3983:
3808:
3577:"Anti-Siglec-8 Antibody for Eosinophilic Gastritis and Duodenitis"
1593:
1484:
1468:
1464:
1409:
1362:
1350:
1346:
1342:
1301:
1277:
2632:"IL-33 enhances Siglec-8 mediated apoptosis of human eosinophils"
1227:
or the carrier molecules bearing them have not been determined.
674:
670:
3882:
3877:
3672:
Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006).
2183:"Glycan array screening reveals a candidate ligand for Siglec-8"
1460:
1452:
1448:
1440:
1421:
1338:
1334:
1330:
1318:
1305:
1285:
1281:
1268:(ROS) production, loss of mitochondrial membrane potential, and
1113:
1101:
1054:
1042:
1030:
574:
120:
107:, SAF2, SIGLEC-8, SIGLEC8L, sialic acid binding Ig like lectin 8
3749:
2578:
Cherry WB, Yoon J, Bartemes KR, Iijima K, Kita H (June 2008).
1417:
1314:
2863:
Carroll DJ, Cao Y, Bochner BS, O'Sullivan JA (October 2021).
1404:
ligands resembles that described in eosinophils primed with
2486:
Cao Y, Rische CH, Bochner BS, O'Sullivan JA (October 2023).
1865:
Angata T, Margulies EH, Green ED, Varki A (September 2004).
1380:
in eosinophils and overcomes the need for cytokine priming (
2917:
Kano G, Almanan M, Bochner BS, Zimmermann N (August 2013).
1761:"Entrez Gene: SIGLEC8 sialic acid binding Ig-like lectin 8"
2761:
American
Journal of Respiratory Cell and Molecular Biology
2330:
American
Journal of Respiratory Cell and Molecular Biology
1400:
pathway licensed by enzymatic removal of these sialylated
1041:
family of transmembrane proteins, Siglec-8 belongs to the
2137:"Human eosinophils express two Siglec-8 splice variants"
376:
2537:
Nutku E, Aizawa H, Hudson SA, Bochner BS (June 2003).
1447:
signaling. In this experimental system, inhibition of
1357:. There was no evidence supporting the involvement of
1252:
have been found to potentiate this cell death effect.
2755:
Nutku-Bilir E, Hudson SA, Bochner BS (January 2008).
541:
3971:
3931:
3863:
3794:
3787:
2722:
1779:
932:
907:
877:
852:
2227:Tateno H, Crocker PR, Paulson JC (November 2005).
1657:
1655:
1653:
1636:
1634:
1632:
1439:resembling regulated necrosis that is promoted by
1372:Disruption of Siglec-8 binding to α2,3-sialylated
1408:in that it involves cell-surface upregulation of
1096:peaks at day 2 and the secondary granule protein
323:
222:
1580:-sulfotransferases, keratan sulfate galactose 6-
3511:
3509:
3308:
3306:
3256:
3254:
3204:
3202:
3200:
2964:
2962:
2912:
2910:
2858:
2856:
2854:
2852:
2802:
2800:
2625:
2623:
2481:
2479:
2477:
2427:
2425:
2423:
2373:
2371:
2369:
2270:
2268:
2266:
2264:
2222:
2220:
2218:
2176:
2174:
2172:
1981:
1979:
1977:
1975:
1973:
1971:
1584:-sulfotransferase (KSGal6ST) and chondroitin 6-
16:Protein-coding gene in the species Homo sapiens
3108:"Siglecs and their roles in the immune system"
3106:Crocker PR, Paulson JC, Varki A (April 2007).
2972:The Journal of Allergy and Clinical Immunology
2923:The Journal of Allergy and Clinical Immunology
2584:The Journal of Allergy and Clinical Immunology
2281:The Journal of Allergy and Clinical Immunology
2141:The Journal of Allergy and Clinical Immunology
2135:Aizawa H, Plitt J, Bochner BS (January 2002).
1860:
1858:
1827:The Journal of Allergy and Clinical Immunology
1816:
1814:
1812:
1810:
1808:
1772:
1770:
1714:
1712:
1710:
1662:GRCm38: Ensembl release 89: ENSMUSG00000039013
1171:immunoreceptor tyrosine-based inhibitory motif
3761:
2630:Na HJ, Hudson SA, Bochner BS (January 2012).
8:
1376:ligands enables Siglec-8 engagement-induced
1641:GRCh38: Ensembl release 89: ENSG00000105366
1495:, on mast cells or unprimed eosinophils).
1396:) or extensive receptor cross-linking. The
1140:In addition, baboon eosinophils as well as
3791:
3768:
3754:
3746:
3736:United States National Library of Medicine
2813:Journal of Allergy and Clinical Immunology
2438:Journal of Allergy and Clinical Immunology
1416:production and requires the activities of
685:
590:
364:
263:
160:
58:
3725:at the U.S. National Library of Medicine
3697:
3653:
3600:
3551:
3541:
3489:
3479:
3438:
3389:
3340:
3330:
3286:
3234:
3180:
3123:
3082:
3032:
3022:
2942:
2890:
2880:
2832:
2780:
2696:
2655:
2603:
2554:
2513:
2503:
2457:
2403:
2349:
2300:
2244:
2198:
2152:
2060:
2011:
1951:
1941:
1900:
1890:
1838:
1736:
613:transmembrane signaling receptor activity
3734:This article incorporates text from the
1628:
18:
1618:eosinophilic gastritis and duodenitis
1260:. Inhibitor studies demonstrate that
328:
289:
284:
227:
186:
181:
7:
1020:Sialic acid-binding Ig-like lectin 8
3581:The New England Journal of Medicine
3468:The Journal of Biological Chemistry
2187:The Journal of Biological Chemistry
1725:The Journal of Biological Chemistry
1349:. The conformational activation of
929:
904:
874:
849:
825:
806:
780:
761:
735:
716:
546:
464:
402:
381:
14:
1353:was dependent on the activity of
1053:Siglec-8 was first identified by
1026:that in humans is encoded by the
3279:10.1111/j.1398-9995.2008.01709.x
3161:Journal of Immunological Methods
2106:10.1111/j.1398-9995.2006.01133.x
2053:10.1111/j.1399-3038.2010.01003.x
2041:Pediatric Allergy and Immunology
1530:Relationships with other siglecs
1435:and Siglec-8 leads to a type of
564:
557:
550:
312:
305:
299:
276:
211:
204:
198:
173:
1072:Siglec-8 is expressed by human
3888:Myelin-associated glycoprotein
1992:Journal of Clinical Immunology
1431:Concurrent stimulation of the
634:integral component of membrane
575:More reference expression data
530:More reference expression data
1:
1535:CD33-related siglec subfamily
1359:protein tyrosine phosphatases
1119:chronic eosinophilic leukemia
297:
196:
4044:Genes on human chromosome 19
3954:N-Acetylglucosamine receptor
3543:10.1371/journal.pone.0068143
3227:10.1182/blood-2006-08-039255
4049:Clusters of differentiation
3804:Asialoglycoprotein receptor
1288:prevented Siglec-8-induced
1080:, and, to a lesser extent,
4070:
3431:10.1016/j.clim.2008.11.009
3112:Nature Reviews. Immunology
3075:10.1038/s41385-020-00336-9
2984:10.1016/j.jaci.2007.10.004
2935:10.1016/j.jaci.2013.03.024
2825:10.1016/j.jaci.2017.08.013
2734:10.1016/j.bbrc.2005.08.202
2648:10.1016/j.cyto.2011.10.007
2596:10.1016/j.jaci.2008.04.005
2556:10.1182/blood-2002-10-3058
2505:10.3389/fimmu.2023.1283370
2450:10.1016/j.jaci.2017.06.028
2293:10.1016/j.jaci.2013.05.018
1123:hypereosinophilic syndrome
1062:hypereosinophilic syndrome
3832:proteochondroitin sulfate
3646:10.1042/0264-6021:3550489
3173:10.1016/j.jim.2007.07.011
3024:10.3389/fimmu.2022.833728
2882:10.3389/fimmu.2021.737988
2698:10.1038/labinvest.2008.82
2004:10.1007/s10875-011-9589-4
1697:"Mouse PubMed Reference:"
1679:"Human PubMed Reference:"
1610:randomized clinical trial
1006:
1001:
997:
990:
974:
955:
936:
911:
900:
881:
856:
845:
832:
828:
813:
809:
800:
787:
783:
768:
764:
755:
742:
738:
723:
719:
710:
695:
688:
684:
668:
593:
589:
572:
549:
540:
527:
476:
467:
414:
405:
375:
367:
363:
346:
333:
296:
275:
266:
262:
245:
232:
195:
172:
163:
159:
114:
111:
101:
94:
89:
66:
61:
44:
39:
34:
30:
26:
21:
3727:Medical Subject Headings
3382:10.4049/jimmunol.0801421
3332:10.1186/1465-9921-11-154
2773:10.1165/rcmb.2007-0154OC
2396:10.4049/jimmunol.1203455
2342:10.1165/rcmb.2010-0007OC
1499:Mast cells and basophils
1355:Bruton's tyrosine kinase
1127:chronic myeloid leukemia
1049:Initial characterization
961:Chr 19: 51.45 – 51.46 Mb
446:internal globus pallidus
3634:The Biochemical Journal
3481:10.1074/jbc.M113.485409
3011:Frontiers in Immunology
2869:Frontiers in Immunology
2492:Frontiers in Immunology
2154:10.1067/mai.2002.120550
1892:10.1073/pnas.0404833101
1840:10.1067/mai.2000.107127
1266:reactive oxygen species
3723:SIGLEC8+protein,+human
2200:10.1074/jbc.M412378200
1791:10.1006/bbrc.2000.3866
1231:Signaling and function
3819:Mannan-binding lectin
3593:10.1056/NEJMoa2012047
3370:Journal of Immunology
2384:Journal of Immunology
2246:10.1093/glycob/cwi097
1738:10.1074/jbc.275.2.861
1540:ITIM-like sequences.
1215:to a greater extent (
189:Chromosome 19 (human)
3319:Respiratory Research
1943:10.1096/fj.13-241497
1833:(6 Pt 1): 1093–100.
1369:, in this pathway.
1108:surface expression.
968:Chr 7: 43 – 43.01 Mb
618:carbohydrate binding
430:right adrenal cortex
291:Chromosome 7 (mouse)
62:List of PDB id codes
35:Available structures
4006:Phytohaemagglutinin
3534:2013PLoSO...868143M
3419:Clinical Immunology
1883:2004PNAS..10113251A
1475:Siglec-8 undergoes
1296:, indicating that β
1160:are not conserved.
660:signal transduction
442:left adrenal cortex
153:SIGLEC8 - orthologs
3738:, which is in the
3690:10.1101/gr.4039406
3063:Mucosal Immunology
1590:Src family kinases
1246:interleukin (IL)-5
790:ENSMUSG00000039013
648:Biological process
627:Cellular component
601:Molecular function
434:left adrenal gland
4031:
4030:
3967:
3966:
3587:(17): 1624–1634.
2978:(2): 499–505.e1.
2287:(1): 240–7.e1–3.
2047:(4 Pt 1): 640–8.
1311:Src family kinase
1037:gene. Within the
1017:
1016:
1013:
1012:
986:
985:
951:
950:
926:
925:
896:
895:
871:
870:
841:
840:
822:
821:
796:
795:
777:
776:
751:
750:
732:
731:
680:
679:
585:
584:
581:
580:
536:
535:
523:
522:
516:intestinal villus
461:
460:
450:prefrontal cortex
359:
358:
258:
257:
85:
84:
81:
80:
45:Ortholog search:
4061:
4011:Pokeweed mitogen
3826:Mannose receptor
3792:
3770:
3763:
3756:
3747:
3711:
3701:
3667:
3657:
3640:(Pt 2): 489–97.
3615:
3614:
3604:
3572:
3566:
3565:
3555:
3545:
3513:
3504:
3503:
3493:
3483:
3474:(37): 26533–45.
3459:
3453:
3452:
3442:
3410:
3404:
3403:
3393:
3361:
3355:
3354:
3344:
3334:
3310:
3301:
3300:
3290:
3258:
3249:
3248:
3238:
3206:
3195:
3194:
3184:
3152:
3146:
3145:
3127:
3103:
3097:
3096:
3086:
3053:
3047:
3046:
3036:
3026:
3002:
2996:
2995:
2966:
2957:
2956:
2946:
2914:
2905:
2904:
2894:
2884:
2860:
2847:
2846:
2836:
2819:(6): 2196–2207.
2804:
2795:
2794:
2784:
2752:
2746:
2745:
2717:
2711:
2710:
2700:
2676:
2670:
2669:
2659:
2627:
2618:
2617:
2607:
2575:
2569:
2568:
2558:
2534:
2528:
2527:
2517:
2507:
2483:
2472:
2471:
2461:
2444:(5): 1774–1785.
2429:
2418:
2417:
2407:
2375:
2364:
2363:
2353:
2321:
2315:
2314:
2304:
2272:
2259:
2258:
2248:
2224:
2213:
2212:
2202:
2178:
2167:
2166:
2156:
2132:
2126:
2125:
2089:
2083:
2082:
2064:
2032:
2026:
2025:
2015:
1983:
1966:
1965:
1955:
1945:
1921:
1915:
1914:
1904:
1894:
1862:
1853:
1852:
1842:
1818:
1803:
1802:
1774:
1765:
1764:
1757:
1751:
1750:
1740:
1716:
1705:
1704:
1693:
1687:
1686:
1675:
1669:
1659:
1648:
1638:
1505:prostaglandin D2
1481:protein kinase C
1327:protein kinase C
999:
998:
970:
963:
946:
930:
921:
905:
901:RefSeq (protein)
891:
875:
866:
850:
826:
807:
781:
762:
736:
717:
686:
591:
577:
568:
561:
554:
547:
532:
496:secondary oocyte
472:
470:Top expressed in
465:
438:substantia nigra
410:
408:Top expressed in
403:
382:
365:
355:
342:
331:
316:
309:
303:
292:
280:
264:
254:
241:
230:
215:
208:
202:
191:
177:
161:
155:
106:
99:
76:
59:
53:
32:
31:
19:
4069:
4068:
4064:
4063:
4062:
4060:
4059:
4058:
4034:
4033:
4032:
4027:
3963:
3927:
3859:
3783:
3774:
3719:
3714:
3678:Genome Research
3670:
3627:
3623:
3621:Further reading
3618:
3574:
3573:
3569:
3515:
3514:
3507:
3461:
3460:
3456:
3412:
3411:
3407:
3363:
3362:
3358:
3312:
3311:
3304:
3260:
3259:
3252:
3208:
3207:
3198:
3154:
3153:
3149:
3125:10.1038/nri2056
3105:
3104:
3100:
3055:
3054:
3050:
3004:
3003:
2999:
2968:
2967:
2960:
2916:
2915:
2908:
2862:
2861:
2850:
2806:
2805:
2798:
2754:
2753:
2749:
2719:
2718:
2714:
2691:(11): 1245–53.
2678:
2677:
2673:
2629:
2628:
2621:
2577:
2576:
2572:
2549:(12): 5014–20.
2536:
2535:
2531:
2485:
2484:
2475:
2431:
2430:
2421:
2390:(12): 5939–48.
2377:
2376:
2367:
2323:
2322:
2318:
2274:
2273:
2262:
2239:(11): 1125–35.
2226:
2225:
2216:
2180:
2179:
2170:
2134:
2133:
2129:
2091:
2090:
2086:
2034:
2033:
2029:
1985:
1984:
1969:
1923:
1922:
1918:
1877:(36): 13251–6.
1864:
1863:
1856:
1820:
1819:
1806:
1776:
1775:
1768:
1759:
1758:
1754:
1718:
1717:
1708:
1695:
1694:
1690:
1677:
1676:
1672:
1660:
1651:
1639:
1630:
1626:
1606:
1604:Clinical trials
1546:
1537:
1532:
1501:
1426:phospholipase C
1323:phospholipase C
1299:
1292:production and
1238:
1233:
1184:
1166:
1135:aplastic anemia
1070:
1051:
1008:View/Edit Mouse
1003:View/Edit Human
966:
959:
956:Location (UCSC)
942:
938:
917:
913:
887:
883:
862:
858:
771:ENSG00000105366
664:
643:
622:
608:protein binding
573:
563:
562:
556:
555:
528:
519:
514:
510:
506:
502:
498:
494:
490:
486:
484:right lung lobe
482:
468:
457:
452:
448:
444:
440:
436:
432:
428:
424:
420:
406:
350:
337:
329:
319:
318:
317:
310:
290:
267:Gene location (
249:
236:
228:
218:
217:
216:
209:
187:
164:Gene location (
115:
102:
95:
68:
46:
17:
12:
11:
5:
4067:
4065:
4057:
4056:
4051:
4046:
4036:
4035:
4029:
4028:
4026:
4025:
4020:
4015:
4014:
4013:
4008:
4003:
4001:Concanavalin A
3993:
3992:
3991:
3986:
3975:
3973:
3969:
3968:
3965:
3964:
3962:
3961:
3956:
3951:
3946:
3941:
3935:
3933:
3929:
3928:
3926:
3925:
3920:
3915:
3910:
3905:
3900:
3895:
3890:
3885:
3880:
3875:
3869:
3867:
3861:
3860:
3858:
3857:
3856:
3855:
3850:
3845:
3840:
3828:
3823:
3822:
3821:
3811:
3806:
3800:
3798:
3796:C-type lectins
3789:
3785:
3784:
3775:
3773:
3772:
3765:
3758:
3750:
3731:
3730:
3718:
3717:External links
3715:
3713:
3712:
3668:
3624:
3622:
3619:
3617:
3616:
3567:
3505:
3454:
3405:
3376:(8): 5333–41.
3356:
3302:
3273:(9): 1156–63.
3250:
3221:(10): 4280–7.
3196:
3167:(1–2): 63–74.
3147:
3098:
3069:(2): 366–376.
3048:
2997:
2958:
2906:
2848:
2796:
2747:
2712:
2671:
2619:
2590:(6): 1484–90.
2570:
2529:
2473:
2419:
2365:
2316:
2260:
2214:
2193:(6): 4307–12.
2168:
2127:
2084:
2027:
1998:(6): 1045–53.
1967:
1936:(3): 1280–93.
1916:
1854:
1804:
1766:
1752:
1706:
1688:
1670:
1649:
1627:
1625:
1622:
1605:
1602:
1545:
1544:Mouse Siglec-F
1542:
1536:
1533:
1531:
1528:
1500:
1497:
1297:
1237:
1234:
1232:
1229:
1188:sialyl Lewis X
1183:
1182:Ligand binding
1180:
1165:
1162:
1144:, a subset of
1069:
1066:
1050:
1047:
1015:
1014:
1011:
1010:
1005:
995:
994:
988:
987:
984:
983:
981:
979:
972:
971:
964:
957:
953:
952:
949:
948:
934:
933:
927:
924:
923:
909:
908:
902:
898:
897:
894:
893:
879:
878:
872:
869:
868:
854:
853:
847:
843:
842:
839:
838:
830:
829:
823:
820:
819:
811:
810:
804:
798:
797:
794:
793:
785:
784:
778:
775:
774:
766:
765:
759:
753:
752:
749:
748:
740:
739:
733:
730:
729:
721:
720:
714:
708:
707:
702:
697:
693:
692:
682:
681:
678:
677:
666:
665:
663:
662:
657:
651:
649:
645:
644:
642:
641:
636:
630:
628:
624:
623:
621:
620:
615:
610:
604:
602:
598:
597:
587:
586:
583:
582:
579:
578:
570:
569:
544:
538:
537:
534:
533:
525:
524:
521:
520:
518:
517:
513:
509:
505:
501:
497:
493:
489:
488:primary oocyte
485:
481:
477:
474:
473:
462:
459:
458:
456:
455:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
412:
411:
399:
398:
390:
379:
373:
372:
369:RNA expression
361:
360:
357:
356:
348:
344:
343:
335:
332:
327:
321:
320:
311:
304:
298:
294:
293:
288:
282:
281:
273:
272:
260:
259:
256:
255:
247:
243:
242:
234:
231:
226:
220:
219:
210:
203:
197:
193:
192:
185:
179:
178:
170:
169:
157:
156:
113:
109:
108:
100:
92:
91:
87:
86:
83:
82:
79:
78:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4066:
4055:
4052:
4050:
4047:
4045:
4042:
4041:
4039:
4024:
4021:
4019:
4018:Legume lectin
4016:
4012:
4009:
4007:
4004:
4002:
3999:
3998:
3997:
3994:
3990:
3987:
3985:
3982:
3981:
3980:
3977:
3976:
3974:
3970:
3960:
3957:
3955:
3952:
3950:
3947:
3945:
3942:
3940:
3937:
3936:
3934:
3930:
3924:
3921:
3919:
3916:
3914:
3911:
3909:
3906:
3904:
3901:
3899:
3896:
3894:
3891:
3889:
3886:
3884:
3881:
3879:
3876:
3874:
3871:
3870:
3868:
3866:
3862:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3836:
3835:
3834:
3833:
3829:
3827:
3824:
3820:
3817:
3816:
3815:
3812:
3810:
3807:
3805:
3802:
3801:
3799:
3797:
3793:
3790:
3786:
3782:
3778:
3771:
3766:
3764:
3759:
3757:
3752:
3751:
3748:
3744:
3743:
3741:
3740:public domain
3737:
3728:
3724:
3721:
3720:
3716:
3709:
3705:
3700:
3695:
3691:
3687:
3683:
3679:
3675:
3669:
3665:
3661:
3656:
3651:
3647:
3643:
3639:
3635:
3631:
3626:
3625:
3620:
3612:
3608:
3603:
3598:
3594:
3590:
3586:
3582:
3578:
3571:
3568:
3563:
3559:
3554:
3549:
3544:
3539:
3535:
3531:
3528:(6): e68143.
3527:
3523:
3519:
3512:
3510:
3506:
3501:
3497:
3492:
3487:
3482:
3477:
3473:
3469:
3465:
3458:
3455:
3450:
3446:
3441:
3436:
3432:
3428:
3425:(1): 157–69.
3424:
3420:
3416:
3409:
3406:
3401:
3397:
3392:
3387:
3383:
3379:
3375:
3371:
3367:
3360:
3357:
3352:
3348:
3343:
3338:
3333:
3328:
3324:
3320:
3316:
3309:
3307:
3303:
3298:
3294:
3289:
3284:
3280:
3276:
3272:
3268:
3264:
3257:
3255:
3251:
3246:
3242:
3237:
3232:
3228:
3224:
3220:
3216:
3212:
3205:
3203:
3201:
3197:
3192:
3188:
3183:
3178:
3174:
3170:
3166:
3162:
3158:
3151:
3148:
3143:
3139:
3135:
3131:
3126:
3121:
3118:(4): 255–66.
3117:
3113:
3109:
3102:
3099:
3094:
3090:
3085:
3080:
3076:
3072:
3068:
3064:
3060:
3052:
3049:
3044:
3040:
3035:
3030:
3025:
3020:
3016:
3012:
3008:
3001:
2998:
2993:
2989:
2985:
2981:
2977:
2973:
2965:
2963:
2959:
2954:
2950:
2945:
2940:
2936:
2932:
2929:(2): 437–45.
2928:
2924:
2920:
2913:
2911:
2907:
2902:
2898:
2893:
2888:
2883:
2878:
2874:
2870:
2866:
2859:
2857:
2855:
2853:
2849:
2844:
2840:
2835:
2830:
2826:
2822:
2818:
2814:
2810:
2803:
2801:
2797:
2792:
2788:
2783:
2778:
2774:
2770:
2766:
2762:
2758:
2751:
2748:
2743:
2739:
2735:
2731:
2728:(3): 918–24.
2727:
2723:
2716:
2713:
2708:
2704:
2699:
2694:
2690:
2686:
2682:
2675:
2672:
2667:
2663:
2658:
2653:
2649:
2645:
2642:(1): 169–74.
2641:
2637:
2633:
2626:
2624:
2620:
2615:
2611:
2606:
2601:
2597:
2593:
2589:
2585:
2581:
2574:
2571:
2566:
2562:
2557:
2552:
2548:
2544:
2540:
2533:
2530:
2525:
2521:
2516:
2511:
2506:
2501:
2497:
2493:
2489:
2482:
2480:
2478:
2474:
2469:
2465:
2460:
2455:
2451:
2447:
2443:
2439:
2435:
2428:
2426:
2424:
2420:
2415:
2411:
2406:
2401:
2397:
2393:
2389:
2385:
2381:
2374:
2372:
2370:
2366:
2361:
2357:
2352:
2347:
2343:
2339:
2336:(2): 238–43.
2335:
2331:
2327:
2320:
2317:
2312:
2308:
2303:
2298:
2294:
2290:
2286:
2282:
2278:
2271:
2269:
2267:
2265:
2261:
2256:
2252:
2247:
2242:
2238:
2234:
2230:
2223:
2221:
2219:
2215:
2210:
2206:
2201:
2196:
2192:
2188:
2184:
2177:
2175:
2173:
2169:
2164:
2160:
2155:
2150:
2146:
2142:
2138:
2131:
2128:
2123:
2119:
2115:
2111:
2107:
2103:
2100:(6): 769–76.
2099:
2095:
2088:
2085:
2080:
2076:
2072:
2068:
2063:
2058:
2054:
2050:
2046:
2042:
2038:
2031:
2028:
2023:
2019:
2014:
2009:
2005:
2001:
1997:
1993:
1989:
1982:
1980:
1978:
1976:
1974:
1972:
1968:
1963:
1959:
1954:
1949:
1944:
1939:
1935:
1931:
1930:FASEB Journal
1927:
1920:
1917:
1912:
1908:
1903:
1898:
1893:
1888:
1884:
1880:
1876:
1872:
1868:
1861:
1859:
1855:
1850:
1846:
1841:
1836:
1832:
1828:
1824:
1817:
1815:
1813:
1811:
1809:
1805:
1800:
1796:
1792:
1788:
1785:(3): 775–81.
1784:
1780:
1773:
1771:
1767:
1762:
1756:
1753:
1748:
1744:
1739:
1734:
1730:
1726:
1722:
1715:
1713:
1711:
1707:
1702:
1698:
1692:
1689:
1684:
1680:
1674:
1671:
1667:
1663:
1658:
1656:
1654:
1650:
1646:
1642:
1637:
1635:
1633:
1629:
1623:
1621:
1619:
1615:
1611:
1603:
1601:
1599:
1595:
1591:
1587:
1583:
1579:
1575:
1571:
1567:
1563:
1559:
1555:
1551:
1543:
1541:
1534:
1529:
1527:
1524:
1522:
1518:
1514:
1510:
1506:
1498:
1496:
1494:
1490:
1486:
1482:
1478:
1473:
1470:
1466:
1462:
1458:
1454:
1450:
1446:
1442:
1438:
1434:
1433:IL-5 receptor
1429:
1427:
1423:
1419:
1415:
1411:
1407:
1403:
1399:
1395:
1391:
1387:
1383:
1379:
1375:
1370:
1368:
1364:
1360:
1356:
1352:
1348:
1344:
1340:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1307:
1303:
1295:
1291:
1287:
1283:
1279:
1275:
1271:
1267:
1263:
1259:
1255:
1251:
1247:
1243:
1235:
1230:
1228:
1226:
1222:
1218:
1214:
1209:
1205:
1200:
1198:
1193:
1189:
1181:
1179:
1176:
1172:
1163:
1161:
1159:
1155:
1151:
1147:
1143:
1138:
1136:
1132:
1128:
1124:
1120:
1115:
1109:
1107:
1103:
1099:
1095:
1091:
1087:
1083:
1079:
1075:
1067:
1065:
1063:
1059:
1056:
1048:
1046:
1044:
1040:
1036:
1032:
1029:
1025:
1021:
1009:
1004:
1000:
996:
993:
989:
982:
980:
977:
973:
969:
965:
962:
958:
954:
947:
945:
941:
935:
931:
928:
922:
920:
916:
910:
906:
903:
899:
892:
890:
886:
880:
876:
873:
867:
865:
861:
855:
851:
848:
846:RefSeq (mRNA)
844:
837:
836:
831:
827:
824:
818:
817:
812:
808:
805:
803:
799:
792:
791:
786:
782:
779:
773:
772:
767:
763:
760:
758:
754:
747:
746:
741:
737:
734:
728:
727:
722:
718:
715:
713:
709:
706:
703:
701:
698:
694:
691:
687:
683:
676:
672:
667:
661:
658:
656:
655:cell adhesion
653:
652:
650:
647:
646:
640:
637:
635:
632:
631:
629:
626:
625:
619:
616:
614:
611:
609:
606:
605:
603:
600:
599:
596:
595:Gene ontology
592:
588:
576:
571:
567:
560:
553:
548:
545:
543:
539:
531:
526:
515:
511:
507:
503:
499:
495:
491:
487:
483:
479:
478:
475:
471:
466:
463:
453:
449:
445:
441:
437:
433:
429:
425:
421:
417:
416:
413:
409:
404:
401:
400:
397:
395:
391:
389:
388:
384:
383:
380:
378:
374:
370:
366:
362:
354:
349:
345:
341:
336:
326:
322:
315:
308:
302:
295:
287:
283:
279:
274:
270:
265:
261:
253:
248:
244:
240:
235:
225:
221:
214:
207:
201:
194:
190:
184:
180:
176:
171:
167:
162:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
110:
105:
98:
93:
88:
77:
75:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
3944:Calreticulin
3907:
3873:Sialoadhesin
3830:
3733:
3732:
3684:(1): 55–65.
3681:
3677:
3637:
3633:
3584:
3580:
3570:
3525:
3521:
3471:
3467:
3457:
3422:
3418:
3408:
3373:
3369:
3359:
3325:(154): 154.
3322:
3318:
3270:
3266:
3218:
3214:
3164:
3160:
3150:
3115:
3111:
3101:
3066:
3062:
3051:
3014:
3010:
3000:
2975:
2971:
2926:
2922:
2872:
2868:
2816:
2812:
2767:(1): 121–4.
2764:
2760:
2750:
2725:
2721:
2715:
2688:
2684:
2674:
2639:
2635:
2587:
2583:
2573:
2546:
2542:
2532:
2495:
2491:
2441:
2437:
2387:
2383:
2333:
2329:
2319:
2284:
2280:
2236:
2233:Glycobiology
2232:
2190:
2186:
2144:
2140:
2130:
2097:
2093:
2087:
2044:
2040:
2030:
1995:
1991:
1933:
1929:
1919:
1874:
1870:
1830:
1826:
1782:
1778:
1755:
1731:(2): 861–6.
1728:
1724:
1700:
1691:
1682:
1673:
1614:lirentelimab
1607:
1585:
1581:
1577:
1573:
1557:
1553:
1549:
1547:
1538:
1525:
1520:
1502:
1492:
1474:
1430:
1401:
1381:
1373:
1371:
1239:
1224:
1220:
1216:
1212:
1203:
1201:
1185:
1167:
1139:
1131:mastocytosis
1110:
1071:
1052:
1027:
1019:
1018:
940:NP_001257948
937:
919:NP_001350477
912:
885:NM_001271019
882:
864:NM_001363548
857:
833:
814:
788:
769:
743:
724:
704:
699:
392:
385:
112:External IDs
67:
3979:Toxalbumins
2498:: 1283370.
1477:endocytosis
1236:Eosinophils
1150:neutrophils
1146:lymphocytes
1074:eosinophils
512:bone marrow
480:granulocyte
454:gallbladder
351:43,008,955
338:43,000,765
330:7|7 B3
250:51,458,456
237:51,450,847
90:Identifiers
4038:Categories
3017:: 833728.
2875:: 737988.
2147:(1): 176.
1668:, May 2017
1647:, May 2017
1624:References
1552:and mouse
1523:ligands.
1517:cell death
1513:cell death
1489:cell death
1437:cell death
1398:cell death
1378:cell death
1294:cell death
1274:cell death
1262:cell death
1258:cell death
1242:cell death
1078:mast cells
1068:Expression
426:lymph node
418:C1 segment
396:(ortholog)
133:HomoloGene
3814:Collectin
1562:ovalbumin
1509:histamine
1197:sialidase
1164:Structure
1142:monocytes
1082:basophils
944:NP_663556
915:NP_055257
889:NM_145581
860:NM_014442
690:Orthologs
141:GeneCards
3996:Mitogens
3959:Selectin
3949:Galectin
3939:Calnexin
3923:SIGLEC12
3918:SIGLEC10
3853:Neurocan
3848:Brevican
3843:Versican
3838:Aggrecan
3708:16344560
3664:11284738
3611:33085861
3562:23840825
3522:PLOS ONE
3500:23880769
3449:19135419
3400:19783675
3351:21040544
3297:18699932
3245:17272508
3191:17716680
3142:26722878
3134:17380156
3093:32814824
3043:35154156
2992:18036650
2953:23684072
2901:34721399
2843:28888781
2791:17690326
2742:16157303
2707:18762778
2666:22079334
2636:Cytokine
2614:18539196
2565:12609831
2524:37928558
2515:10623328
2468:28734845
2414:23677475
2360:20395633
2311:23830412
2255:15972893
2209:15563466
2163:11799386
2122:21873800
2114:16677248
2079:27714390
2071:20337967
2062:10411049
2022:21938510
1962:24308974
1911:15331780
1849:10856141
1799:11095983
1747:10625619
1664:–
1643:–
1554:Siglecf
1158:epitopes
1154:ortholog
1058:homology
992:Wikidata
669:Sources:
639:membrane
229:19q13.41
3913:SIGLEC9
3908:SIGLEC8
3903:SIGLEC7
3898:SIGLEC6
3893:SIGLEC5
3781:lectins
3777:Protein
3699:1356129
3655:1221762
3602:7600443
3553:3695997
3530:Bibcode
3491:3772201
3440:2683248
3391:2788790
3342:2988013
3288:2726770
3267:Allergy
3236:1885492
3182:2670191
3084:7946634
3034:8837033
2944:4042061
2892:8549629
2834:5839929
2782:2176128
2657:3282301
2605:2821937
2459:6445644
2405:3679360
2351:3049235
2302:3874253
2094:Allergy
2013:3329870
1953:3929681
1879:Bibcode
1666:Ensembl
1645:Ensembl
1550:SIGLEC8
1424:, and
1384:, with
1270:caspase
1121:(CEL),
1090:allergy
1035:SIGLEC9
1028:SIGLEC8
1024:protein
802:UniProt
757:Ensembl
696:Species
675:QuickGO
371:pattern
145:SIGLEC8
129:2681107
104:SIGLEC8
97:Aliases
22:SIGLEC8
4054:SIGLEC
4023:BanLec
3865:SIGLEC
3788:Animal
3729:(MeSH)
3706:
3696:
3662:
3652:
3609:
3599:
3560:
3550:
3498:
3488:
3447:
3437:
3398:
3388:
3349:
3339:
3295:
3285:
3243:
3233:
3189:
3179:
3140:
3132:
3091:
3081:
3041:
3031:
2990:
2951:
2941:
2899:
2889:
2841:
2831:
2789:
2779:
2740:
2705:
2664:
2654:
2612:
2602:
2563:
2522:
2512:
2466:
2456:
2412:
2402:
2358:
2348:
2309:
2299:
2253:
2207:
2161:
2120:
2112:
2077:
2069:
2059:
2020:
2010:
1960:
1950:
1909:
1902:516556
1899:
1847:
1797:
1745:
1548:While
1483:, and
1390:GM-CSF
1341:, and
1250:GM-CSF
1208:glycan
1192:fucose
1175:lectin
1148:, and
1106:FcεRIα
1094:GATA-1
1086:asthma
1039:siglec
978:search
976:PubMed
835:Q920G3
816:Q9NYZ4
745:233186
712:Entrez
542:BioGPS
508:zygote
500:morula
492:embryo
422:spleen
121:605639
3989:Ricin
3984:Abrin
3972:Plant
3932:Other
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