242:
219:
116:
141:
1530:
248:
147:
1355:
1210:
expression is increased in colorectal tumor tissues compared to matched nontumor colon tissues. Increased expression of the encoded protein was associated with decreased survival times in colorectal cancer patients.
1164:
patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Epileptic encephalopathy early infantile type 3 is characterized by a very early onset, erratic and fragmentary
1377:"SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate"
255:
154:
1767:
717:
698:
77:
1191:
is high in most tissues, expression is particularly strong in the developing brain, with regions of the brain involved in the genesis and control of
1787:
1324:
1306:
1422:
241:
964:
218:
957:
1173:
is poor, with no effective treatment, and children with the condition either die within 1 to 2 years after birth or survive in a
1153:
1293:
1272:
140:
115:
1289:
1268:
1236:
1094:
254:
153:
57:
1174:
247:
146:
1037:
1735:
Palmieri F (2013). "The mitochondrial transporter family SLC25: identification, properties and physiopathology".
1087:
762:
65:
1656:
Molinari F, Raas-Rothschild A, Rio M, Fiermonte G, Encha-Razavi F, Palmieri L, et al. (February 2005).
1607:
Poduri A, Heinzen EL, Chitsazzadeh V, Lasorsa FM, Elhosary PC, LaCoursiere CM, et al. (December 2013).
743:
1157:
1090:
129:
44:
1513:"SLC25A22 - Mitochondrial glutamate carrier 1 - Homo sapiens (Human) - SLC25A22 gene & protein"
940:
936:
928:
903:
899:
873:
869:
861:
836:
832:
1220:
1192:
89:
932:
907:
865:
840:
1658:"Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsy"
1752:
1687:
1638:
1586:
1469:
1398:
1161:
1123:
1056:
1045:
85:
37:
1744:
1677:
1669:
1628:
1620:
1576:
1568:
1459:
1451:
1388:
334:
265:
209:
164:
1534:
1529:
1052:
309:
1682:
1657:
1633:
1608:
1581:
1556:
1464:
1439:
1216:
1212:
1048:
1705:
632:
627:
622:
617:
612:
607:
602:
597:
581:
576:
571:
566:
550:
545:
540:
535:
530:
525:
1781:
1771:
1487:
1440:"Integration of cardiac proteome biology and medicine by a specialized knowledgebase"
1359:
1110:
1075:
1034:
1031:
512:
69:
1114:
327:
106:
1455:
1180:
Migrating partial seizures in infancy, caused by a specific G110R mutation in the
1393:
1376:
93:
1329:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1311:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1148:
gene cause early infantile epileptic encephalopathy 3 (EIEE3), a severe form of
1083:
1082:
spanning 7,807 base pairs. The gene produces a 34.5 kDa protein composed of 323
410:
1748:
1224:
226:
123:
73:
1438:
Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, et al. (October 2013).
1170:
1166:
1128:
662:
470:
348:
293:
280:
192:
179:
81:
1756:
1691:
1642:
1590:
1473:
1402:
1375:
Wong CC, Qian Y, Li X, Xu J, Kang W, Tong JH, et al. (November 2016).
1572:
1342:
1004:
999:
1512:
1149:
1059:
1041:
988:
807:
788:
1244:
1240:
1169:, massive myoclonus, partial motor seizures and late tonic spasms. The
1020:
774:
729:
1624:
972:
684:
1609:"SLC25A22 is a novel gene for migrating partial seizures in infancy"
1673:
48:, EIEE3, GC1, NET44, GC-1, solute carrier family 25 member 22, DEE3
1358:
This article incorporates text from this source, which is in the
647:
643:
1426:
1079:
1027:
61:
541:
high-affinity glutamate transmembrane transporter activity
1533: This article incorporates text available under the
1215:
of this gene in mutant colorectal cells decreased their
317:
1492:
Cardiac
Organellar Protein Atlas Knowledgebase (COPaKB)
482:
921:
892:
854:
825:
421:
dentate gyrus of hippocampal formation granule cell
1285:
1283:
1281:
1264:
1262:
1260:
1507:
1505:
1503:
1501:
1343:"Entrez Gene: Solute carrier family 25 member 22"
1044:in this gene are associated with early infantile
264:
163:
1117:, across the inner mitochondrial membrane. Both
1418:
1416:
1414:
1412:
1156:or spasms beginning in infancy with a specific
16:Protein-coding gene in the species Homo sapiens
1557:"UniProt: the universal protein knowledgebase"
1488:"SLC25A22 - Mitochondrial glutamate carrier 1"
1290:GRCm38: Ensembl release 89: ENSMUSG00000019082
546:L-aspartate transmembrane transporter activity
531:L-glutamate transmembrane transporter activity
8:
1370:
1368:
1269:GRCh38: Ensembl release 89: ENSG00000177542
1109:is involved in the transport of glutamate,
1768:United States National Library of Medicine
658:
508:
305:
204:
101:
1681:
1632:
1580:
1463:
1392:
1766:This article incorporates text from the
1555:The UniProt Consortium (January 2017).
1256:
18:
1602:
1600:
1550:
1548:
1546:
1544:
269:
230:
225:
168:
127:
122:
7:
536:amino acid:proton symporter activity
1423:Online Mendelian Inheritance in Man
633:L-aspartate transmembrane transport
603:L-glutamate transmembrane transport
1662:American Journal of Human Genetics
1017:Solute carrier family 25 member 22
918:
889:
851:
822:
798:
779:
753:
734:
708:
689:
551:transmembrane transporter activity
487:
405:
343:
322:
14:
1023:that in humans is encoded by the
623:aspartate transmembrane transport
1528:
1353:
1074:gene is located on the p arm of
253:
246:
240:
217:
152:
145:
139:
114:
1127:are mitochondrial glutamate/H+
618:proton transmembrane transport
582:integral component of membrane
471:More reference expression data
359:right hemisphere of cerebellum
1:
1737:Molecular Aspects of Medicine
1456:10.1161/CIRCRESAHA.113.301151
1055:of this gene is increased in
238:
137:
1788:Genes on human chromosome 11
1394:10.1053/j.gastro.2016.07.011
1095:mitochondrial inner membrane
577:mitochondrial inner membrane
1175:persistent vegetative state
1086:. The encoded protein is a
1078:in position 15.5 and has 9
1804:
1199:during human development.
1152:characterized by frequent
1749:10.1016/j.mam.2012.05.005
1325:"Mouse PubMed Reference:"
1307:"Human PubMed Reference:"
1247:, and 43 other proteins.
1003:
998:
994:
987:
971:
965:Chr 7: 141.01 – 141.02 Mb
952:
925:
896:
885:
858:
829:
818:
805:
801:
786:
782:
773:
760:
756:
741:
737:
728:
715:
711:
696:
692:
683:
668:
661:
657:
641:
511:
507:
495:
490:
481:
468:
417:
408:
367:anterior cingulate cortex
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1195:specifically expressing
1184:gene, can be inherited.
1140:Epileptic encephalopathy
628:malate-aspartate shuttle
1187:Although expression of
1105:The protein encoded by
613:mitochondrial transport
598:transmembrane transport
1706:"SLC25A22 interactors"
1561:Nucleic Acids Research
1030:. This gene encodes a
437:neural layer of retina
433:superior frontal gyrus
1135:Clinical significance
1091:transmembrane protein
958:Chr 11: 0.79 – 0.8 Mb
453:medial dorsal nucleus
425:primary visual cortex
130:Chromosome 11 (human)
1444:Circulation Research
1235:The encoded protein
232:Chromosome 7 (mouse)
94:SLC25A22 - orthologs
1613:Annals of Neurology
1573:10.1093/nar/gkw1099
1770:, which is in the
1193:myoclonic seizures
763:ENSMUSG00000019082
591:Biological process
560:Cellular component
526:symporter activity
519:Molecular function
457:left lobe of liver
387:anterior pituitary
363:right frontal lobe
1625:10.1002/ana.23998
1567:(D1): D158–D169.
1427:SLC25A22 - 609302
1387:(5): 945–960.e6.
1203:Colorectal cancer
1162:suppression-burst
1144:Mutations in the
1014:
1013:
1010:
1009:
983:
982:
948:
947:
915:
914:
881:
880:
848:
847:
814:
813:
795:
794:
769:
768:
750:
749:
724:
723:
705:
704:
653:
652:
503:
502:
499:
498:
477:
476:
464:
463:
441:cerebellar cortex
429:intestinal villus
402:
401:
395:cerebellar vermis
391:nucleus accumbens
375:prefrontal cortex
300:
299:
199:
198:
1795:
1760:
1721:
1720:
1718:
1717:
1702:
1696:
1695:
1685:
1653:
1647:
1646:
1636:
1604:
1595:
1594:
1584:
1552:
1539:
1532:
1526:
1524:
1523:
1509:
1496:
1495:
1484:
1478:
1477:
1467:
1435:
1429:
1420:
1407:
1406:
1396:
1381:Gastroenterology
1372:
1363:
1357:
1356:
1352:
1350:
1349:
1339:
1333:
1332:
1321:
1315:
1314:
1303:
1297:
1287:
1276:
1266:
996:
995:
967:
960:
943:
919:
910:
890:
886:RefSeq (protein)
876:
852:
843:
823:
799:
780:
754:
735:
709:
690:
659:
509:
488:
473:
413:
411:Top expressed in
406:
371:body of pancreas
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
1803:
1802:
1798:
1797:
1796:
1794:
1793:
1792:
1778:
1777:
1763:
1743:(2–3): 465–84.
1734:
1730:
1728:Further reading
1725:
1724:
1715:
1713:
1704:
1703:
1699:
1655:
1654:
1650:
1606:
1605:
1598:
1554:
1553:
1542:
1521:
1519:
1517:www.uniprot.org
1511:
1510:
1499:
1486:
1485:
1481:
1437:
1436:
1432:
1421:
1410:
1374:
1373:
1366:
1354:
1347:
1345:
1341:
1340:
1336:
1323:
1322:
1318:
1305:
1304:
1300:
1288:
1279:
1267:
1258:
1253:
1233:
1205:
1142:
1137:
1103:
1093:located in the
1068:
1005:View/Edit Mouse
1000:View/Edit Human
963:
956:
953:Location (UCSC)
939:
935:
931:
927:
906:
902:
898:
872:
868:
864:
860:
839:
835:
831:
744:ENSG00000177542
637:
586:
555:
469:
460:
455:
451:
449:piriform cortex
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
383:Brodmann area 9
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1801:
1799:
1791:
1790:
1780:
1779:
1762:
1761:
1731:
1729:
1726:
1723:
1722:
1697:
1674:10.1086/427564
1648:
1596:
1540:
1497:
1479:
1450:(9): 1043–53.
1430:
1408:
1364:
1334:
1316:
1298:
1277:
1255:
1254:
1252:
1249:
1232:
1229:
1204:
1201:
1154:tonic seizures
1141:
1138:
1136:
1133:
1102:
1099:
1067:
1064:
1049:encephalopathy
1012:
1011:
1008:
1007:
1002:
992:
991:
985:
984:
981:
980:
978:
976:
969:
968:
961:
954:
950:
949:
946:
945:
923:
922:
916:
913:
912:
894:
893:
887:
883:
882:
879:
878:
856:
855:
849:
846:
845:
827:
826:
820:
816:
815:
812:
811:
803:
802:
796:
793:
792:
784:
783:
777:
771:
770:
767:
766:
758:
757:
751:
748:
747:
739:
738:
732:
726:
725:
722:
721:
713:
712:
706:
703:
702:
694:
693:
687:
681:
680:
675:
670:
666:
665:
655:
654:
651:
650:
639:
638:
636:
635:
630:
625:
620:
615:
610:
605:
600:
594:
592:
588:
587:
585:
584:
579:
574:
569:
563:
561:
557:
556:
554:
553:
548:
543:
538:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1800:
1789:
1786:
1785:
1783:
1776:
1775:
1773:
1772:public domain
1769:
1758:
1754:
1750:
1746:
1742:
1738:
1733:
1732:
1727:
1711:
1707:
1701:
1698:
1693:
1689:
1684:
1679:
1675:
1671:
1667:
1663:
1659:
1652:
1649:
1644:
1640:
1635:
1630:
1626:
1622:
1619:(6): 873–82.
1618:
1614:
1610:
1603:
1601:
1597:
1592:
1588:
1583:
1578:
1574:
1570:
1566:
1562:
1558:
1551:
1549:
1547:
1545:
1541:
1538:
1536:
1531:
1518:
1514:
1508:
1506:
1504:
1502:
1498:
1493:
1489:
1483:
1480:
1475:
1471:
1466:
1461:
1457:
1453:
1449:
1445:
1441:
1434:
1431:
1428:
1424:
1419:
1417:
1415:
1413:
1409:
1404:
1400:
1395:
1390:
1386:
1382:
1378:
1371:
1369:
1365:
1361:
1360:public domain
1344:
1338:
1335:
1330:
1326:
1320:
1317:
1312:
1308:
1302:
1299:
1295:
1291:
1286:
1284:
1282:
1278:
1274:
1270:
1265:
1263:
1261:
1257:
1250:
1248:
1246:
1242:
1238:
1230:
1228:
1226:
1222:
1221:proliferation
1218:
1214:
1209:
1202:
1200:
1198:
1194:
1190:
1185:
1183:
1178:
1176:
1172:
1168:
1163:
1159:
1155:
1151:
1147:
1139:
1134:
1132:
1130:
1126:
1125:
1120:
1116:
1112:
1111:cotransported
1108:
1100:
1098:
1096:
1092:
1089:
1085:
1081:
1077:
1076:chromosome 11
1073:
1065:
1063:
1061:
1058:
1054:
1050:
1047:
1043:
1039:
1036:
1033:
1032:mitochondrial
1029:
1026:
1022:
1018:
1006:
1001:
997:
993:
990:
986:
979:
977:
974:
970:
966:
962:
959:
955:
951:
944:
942:
938:
934:
930:
924:
920:
917:
911:
909:
905:
901:
895:
891:
888:
884:
877:
875:
871:
867:
863:
857:
853:
850:
844:
842:
838:
834:
828:
824:
821:
819:RefSeq (mRNA)
817:
810:
809:
804:
800:
797:
791:
790:
785:
781:
778:
776:
772:
765:
764:
759:
755:
752:
746:
745:
740:
736:
733:
731:
727:
720:
719:
714:
710:
707:
701:
700:
695:
691:
688:
686:
682:
679:
676:
674:
671:
667:
664:
660:
656:
649:
645:
640:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
608:ion transport
606:
604:
601:
599:
596:
595:
593:
590:
589:
583:
580:
578:
575:
573:
572:mitochondrion
570:
568:
565:
564:
562:
559:
558:
552:
549:
547:
544:
542:
539:
537:
534:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1765:
1764:
1740:
1736:
1714:. Retrieved
1709:
1700:
1668:(2): 334–9.
1665:
1661:
1651:
1616:
1612:
1564:
1560:
1527:
1520:. Retrieved
1516:
1491:
1482:
1447:
1443:
1433:
1384:
1380:
1346:. Retrieved
1337:
1328:
1319:
1310:
1301:
1234:
1231:Interactions
1207:
1206:
1196:
1188:
1186:
1181:
1179:
1145:
1143:
1122:
1118:
1106:
1104:
1071:
1069:
1024:
1016:
1015:
941:NP_001347653
937:NP_001347652
929:NP_001171047
926:
904:NP_001177990
900:NP_001177989
897:
874:NM_001360724
870:NM_001360723
862:NM_001177576
859:
837:NM_001191061
833:NM_001191060
830:
806:
787:
761:
742:
716:
697:
677:
672:
333:
326:
292:141,017,805
279:141,009,657
53:External IDs
1160:finding of
1084:amino acids
271:7|7 F5
31:Identifiers
1716:2018-08-26
1712:. EMBL-EBI
1522:2018-08-24
1348:2016-10-15
1296:, May 2017
1275:, May 2017
1251:References
1129:symporters
1088:multi-pass
1057:colorectal
1053:Expression
337:(ortholog)
74:HomoloGene
1535:CC BY 4.0
1237:interacts
1217:migration
1213:Knockdown
1171:prognosis
1167:myoclonus
1066:Structure
1046:epileptic
1042:Mutations
1035:glutamate
933:NP_080922
908:NP_078974
866:NM_026646
841:NM_024698
663:Orthologs
445:subiculum
82:GeneCards
1782:Category
1757:23266187
1692:15592994
1643:24596948
1591:27899622
1537:license.
1474:23965338
1425:(OMIM):
1403:27451147
1292:–
1271:–
1225:invasion
1208:SLC25A22
1197:SLC25A22
1189:SLC25A22
1182:SLC25A22
1150:epilepsy
1146:SLC25A22
1124:SLC25A18
1119:SLC25A22
1107:SLC25A22
1101:Function
1072:SLC25A22
1025:SLC25A22
989:Wikidata
642:Sources:
567:membrane
379:amygdala
191:798,281
178:790,475
86:SLC25A22
45:SLC25A22
22:SLC25A22
1683:1196378
1634:4031329
1582:5210571
1465:4076475
1294:Ensembl
1273:Ensembl
1245:NDUFAF4
1241:SLC38A1
1062:cells.
1038:carrier
1021:protein
775:UniProt
730:Ensembl
669:Species
648:QuickGO
312:pattern
170:11p15.5
70:1915517
38:Aliases
1755:
1710:IntAct
1690:
1680:
1641:
1631:
1589:
1579:
1472:
1462:
1401:
1223:, and
975:search
973:PubMed
808:Q9D6M3
789:Q9H936
685:Entrez
483:BioGPS
62:609302
1239:with
1113:with
1080:exons
1060:tumor
1019:is a
718:68267
699:79751
678:Mouse
673:Human
644:Amigo
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:69383
1753:PMID
1688:PMID
1639:PMID
1587:PMID
1470:PMID
1399:PMID
1121:and
1070:The
1028:gene
318:Bgee
266:Band
227:Chr.
165:Band
124:Chr.
58:OMIM
1745:doi
1678:PMC
1670:doi
1629:PMC
1621:doi
1577:PMC
1569:doi
1460:PMC
1452:doi
1448:113
1389:doi
1385:151
1158:EEG
491:n/a
288:End
187:End
90:OMA
66:MGI
1784::
1751:.
1741:34
1739:.
1708:.
1686:.
1676:.
1666:76
1664:.
1660:.
1637:.
1627:.
1617:74
1615:.
1611:.
1599:^
1585:.
1575:.
1565:45
1563:.
1559:.
1543:^
1515:.
1500:^
1490:.
1468:.
1458:.
1446:.
1442:.
1411:^
1397:.
1383:.
1379:.
1367:^
1327:.
1309:.
1280:^
1259:^
1243:,
1227:.
1219:,
1177:.
1131:.
1115:H+
1097:.
1051:.
1040:.
646:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1774:.
1759:.
1747::
1719:.
1694:.
1672::
1645:.
1623::
1593:.
1571::
1525:.
1494:.
1476:.
1454::
1405:.
1391::
1362:.
1351:.
1331:.
1313:.
212:)
109:)
92::
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