253:
230:
127:
152:
259:
158:
1577:
1077:
This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and
1286:
Quadri M, Federico A, Zhao T, Breedveld GJ, Battisti C, Delnooz C, Severijnen LA, Di Toro
Mammarella L, Mignarri A, Monti L, Sanna A, Lu P, Punzo F, Cossu G, Willemsen R, Rasi F, Oostra BA, van de Warrenburg BP, Bonifati V (2012).
1330:
Tuschl K, Clayton PT, Gospe SM, Gulab S, Ibrahim S, Singhi P, Aulakh R, Ribeiro RT, Barsottini OG, Zaki MS, Del
Rosario ML, Dyack S, Price V, Rideout A, Gordon K, Wevers RA, Chong WK, Mills PB (2012).
1541:
Fujishiro H, Yoshida M, Nakano Y, Himeno S (2014). "Interleukin-6 enhances manganese accumulation in SH-SY5Y cells: implications of the up-regulation of ZIP14 and the down-regulation of ZnT10".
1200:"In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression"
266:
165:
1634:
783:
88:
764:
1659:
1375:"Efflux function, tissue-specific expression and intracellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeostasis"
1332:"Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man"
1155:
1622:
1137:
1654:
999:
252:
1006:
229:
1124:
1103:
1120:
151:
126:
1099:
265:
164:
68:
1289:"Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease"
258:
157:
1243:
Wang L, McDonnell SK, Hebbring SJ, Cunningham JM, St Sauver J, Cerhan JR, Isaya G, Schaid DJ, Thibodeau SN (2008).
1615:
828:
76:
809:
1078:
adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. .
1608:
1501:
140:
55:
982:
957:
927:
906:
898:
961:
1476:
100:
953:
902:
1558:
1529:
1468:
1439:
1396:
1361:
1318:
1274:
1231:
96:
48:
1592:
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1519:
1509:
1460:
1429:
1421:
1386:
1351:
1343:
1308:
1300:
1264:
1256:
1221:
1211:
345:
276:
220:
175:
1451:
Ribeiro RT, dos Santos-Neto D, Braga-Neto P, Barsottini OG (2013). "Inherited manganism".
320:
1505:
1410:"Manganese efflux in Parkinsonism: insights from newly characterized SLC30A10 mutations"
1524:
1489:
1434:
1409:
1356:
1331:
1313:
1288:
1269:
1244:
1226:
1199:
698:
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638:
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628:
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541:
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523:
80:
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1480:
1464:
338:
117:
1260:
1514:
104:
1160:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1142:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1425:
1347:
1304:
421:
59:, HMDPC, ZNT10, ZNT8, ZRC1, ZnT-10, solute carrier family 30 member 10, HMNDYT1
237:
134:
84:
728:
481:
359:
304:
291:
203:
190:
92:
1562:
1533:
1472:
1443:
1400:
1365:
1322:
1278:
1235:
1216:
1173:
1046:
1041:
1030:
873:
854:
1373:
Bosomworth HJ, Thornton JK, Coneyworth LJ, Ford D, Valentine RA (2012).
17:
1554:
1391:
1374:
1062:
840:
795:
1014:
750:
1576:
679:
negative regulation of reactive oxygen species biosynthetic process
713:
709:
1584:
1066:
72:
1245:"Polymorphisms in mitochondrial genes and prostate cancer risk"
1490:"Altered expression of ZnT10 in Alzheimer's disease brain"
328:
1596:
1488:
Bosomworth HJ, Adlard PA, Ford D, Valentine RA (2013).
493:
1198:Seve M, Chimienti F, Devergnas S, Favier A (2004).
975:
946:
920:
891:
1116:
1114:
1112:
1095:
1093:
1091:
654:epidermal growth factor receptor signaling pathway
1174:"Entrez Gene: Solute carrier family 30 member 10"
275:
174:
689:regulation of cellular response to manganese ion
552:manganese ion transmembrane transporter activity
659:negative regulation of neuron apoptotic process
27:Protein-coding gene in the species Homo sapiens
1121:GRCm38: Ensembl release 89: ENSMUSG00000026614
1616:
8:
664:positive regulation of ERK1 and ERK2 cascade
1100:GRCh38: Ensembl release 89: ENSG00000196660
542:zinc ion transmembrane transporter activity
1635:United States National Library of Medicine
1623:
1609:
1065:that in humans is encoded by the SLC30A10
724:
694:negative regulation of cellular senescence
519:
316:
215:
112:
1523:
1513:
1433:
1390:
1355:
1312:
1268:
1225:
1215:
537:cation transmembrane transporter activity
1633:This article incorporates text from the
1087:
614:regulation of sequestering of zinc ion
29:
1408:DeWitt MR, Chen P, Aschner M (2013).
669:manganese ion transmembrane transport
280:
241:
236:
179:
138:
133:
7:
1573:
1571:
1595:. You can help Knowledge (XXG) by
1059:Solute carrier family 30 member 10
972:
943:
917:
888:
864:
845:
819:
800:
774:
755:
498:
416:
354:
333:
25:
1249:Cancer Epidemiol. Biomarkers Prev
1575:
684:cellular response to angiotensin
674:regulation of zinc ion transport
649:zinc ion transmembrane transport
436:lumbar subsegment of spinal cord
264:
257:
251:
228:
163:
156:
150:
125:
1465:10.1016/j.clineuro.2012.12.032
699:cation transmembrane transport
568:integral component of membrane
482:More reference expression data
1:
1660:Human chromosome 1 gene stubs
1414:Biochem. Biophys. Res. Commun
1261:10.1158/1055-9965.EPI-08-0434
452:epithelium of small intestine
249:
148:
1515:10.1371/journal.pone.0065475
390:Epithelium of choroid plexus
1655:Genes on human chromosome 1
1676:
1570:
1426:10.1016/j.bbrc.2013.01.058
1348:10.1016/j.ajhg.2012.01.018
1305:10.1016/j.ajhg.2012.01.017
394:retinal pigment epithelium
378:mucosa of transverse colon
1156:"Mouse PubMed Reference:"
1138:"Human PubMed Reference:"
1045:
1040:
1036:
1029:
1013:
1000:Chr 1: 219.69 – 219.96 Mb
994:
979:
950:
939:
924:
895:
884:
871:
867:
852:
848:
839:
826:
822:
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197:
184:
147:
124:
115:
111:
66:
63:
53:
46:
41:
37:
32:
1007:Chr 1: 185.19 – 185.2 Mb
644:transmembrane transport
619:manganese ion transport
406:mucosa of sigmoid colon
1217:10.1186/1471-2164-5-32
1453:Clin Neurol Neurosurg
624:response to zinc ion
243:Chromosome 1 (mouse)
141:Chromosome 1 (human)
105:SLC30A10 - orthologs
1506:2013PLoSO...865475B
456:ganglionic eminence
374:right lobe of liver
1637:, which is in the
1583:This article on a
1555:10.1039/c3mt00362k
1392:10.1039/c2mt20088k
829:ENSMUSG00000026614
634:zinc ion transport
607:Biological process
593:recycling endosome
561:Cellular component
530:Molecular function
448:left lobe of liver
402:buccal mucosa cell
1604:
1603:
1336:Am. J. Hum. Genet
1293:Am. J. Hum. Genet
1056:
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1024:
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861:
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835:
834:
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719:
718:
514:
513:
510:
509:
488:
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474:
413:
412:
311:
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16:(Redirected from
1667:
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1128:
1118:
1107:
1097:
1038:
1037:
1009:
1002:
985:
973:
964:
944:
940:RefSeq (protein)
930:
918:
909:
889:
865:
846:
820:
801:
775:
756:
725:
629:cation transport
520:
499:
484:
440:ventricular zone
424:
422:Top expressed in
417:
382:endothelial cell
362:
360:Top expressed in
355:
334:
317:
307:
294:
283:
268:
261:
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1569:
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1487:
1450:
1407:
1372:
1329:
1285:
1255:(12): 3558–66.
1242:
1197:
1193:
1191:Further reading
1188:
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1119:
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1098:
1089:
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1075:
1047:View/Edit Mouse
1042:View/Edit Human
1005:
998:
995:Location (UCSC)
981:
960:
956:
952:
926:
905:
901:
897:
810:ENSG00000196660
703:
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598:plasma membrane
588:Golgi apparatus
556:
547:protein binding
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219:Gene location (
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116:Gene location (
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583:early endosome
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370:jejunal mucosa
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321:RNA expression
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2:
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1640:
1639:public domain
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1526:
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1516:
1511:
1507:
1503:
1500:(5): e65475.
1499:
1495:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1462:
1459:(8): 1536–8.
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1427:
1423:
1419:
1415:
1411:
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1388:
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1380:
1376:
1371:
1367:
1363:
1358:
1353:
1349:
1345:
1342:(3): 457–66.
1341:
1337:
1333:
1328:
1324:
1320:
1315:
1310:
1306:
1302:
1299:(3): 467–77.
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1016:
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938:
931:
929:
923:
919:
916:
910:
908:
904:
900:
894:
890:
887:
885:RefSeq (mRNA)
883:
876:
875:
870:
866:
863:
857:
856:
851:
847:
844:
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831:
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645:
642:
640:
639:ion transport
637:
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560:
559:
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550:
548:
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543:
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538:
535:
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532:
529:
528:
525:
524:Gene ontology
521:
517:
505:
500:
497:
495:
491:
483:
478:
467:
463:
459:
455:
451:
447:
443:
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70:
62:
57:
50:
45:
40:
36:
31:
19:
1632:
1631:
1597:expanding it
1589:chromosome 1
1582:
1549:(4): 944–9.
1546:
1542:
1497:
1493:
1456:
1452:
1417:
1413:
1385:(8): 771–9.
1382:
1378:
1339:
1335:
1296:
1292:
1252:
1248:
1207:
1204:BMC Genomics
1203:
1177:. Retrieved
1168:
1159:
1150:
1141:
1132:
1076:
1058:
1057:
983:NP_001028458
980:
958:NP_001363858
951:
928:NM_001033286
925:
907:NM_001376929
899:NM_001004433
896:
872:
853:
827:
808:
782:
763:
743:
738:
344:
337:
303:185,200,959
290:185,187,045
202:219,959,018
189:219,685,427
64:External IDs
1543:Metallomics
1379:Metallomics
962:NP_061183.2
282:1|1 H5
42:Identifiers
1649:Categories
1420:(1): 1–4.
1179:2017-11-03
1127:, May 2017
1106:, May 2017
1082:References
348:(ortholog)
85:HomoloGene
1587:on human
1210:(1): 32.
954:NP_061183
903:NM_018713
729:Orthologs
93:GeneCards
1563:24576911
1534:23741496
1494:PLOS ONE
1473:23369405
1444:23357421
1401:22706290
1366:22341972
1323:22341971
1279:19064571
1236:15154973
1123:–
1102:–
1073:Function
1031:Wikidata
708:Sources:
578:endosome
573:membrane
468:yolk sac
432:duodenum
398:testicle
386:duodenum
97:SLC30A10
56:SLC30A10
33:SLC30A10
18:SLC30A10
1525:3669266
1502:Bibcode
1481:5775675
1435:3594538
1357:3309187
1314:3309204
1270:2750891
1125:Ensembl
1104:Ensembl
1063:protein
841:UniProt
796:Ensembl
735:Species
714:QuickGO
464:jejunum
323:pattern
81:2685058
49:Aliases
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1017:search
1015:PubMed
874:Q3UVU3
855:Q6XR72
784:226781
751:Entrez
494:BioGPS
460:embryo
89:100946
73:611146
1591:is a
1477:S2CID
1061:is a
765:55532
744:Mouse
739:Human
710:Amigo
444:liver
346:Mouse
339:Human
286:Start
221:Mouse
185:Start
118:Human
1593:stub
1585:gene
1559:PMID
1530:PMID
1469:PMID
1440:PMID
1397:PMID
1362:PMID
1319:PMID
1275:PMID
1232:PMID
1067:gene
329:Bgee
277:Band
238:Chr.
181:1q41
176:Band
135:Chr.
69:OMIM
1551:doi
1520:PMC
1510:doi
1461:doi
1457:115
1430:PMC
1422:doi
1418:432
1387:doi
1352:PMC
1344:doi
1309:PMC
1301:doi
1265:PMC
1257:doi
1222:PMC
1212:doi
502:n/a
299:End
198:End
101:OMA
77:MGI
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