147:
124:
398:
153:
1053:
membrane of the small intestines, while also exchanging sodium ions and glucose from the tubule of the nephron. The SGLT1 protein is able to uptake glucose through cellular membranes through coupling the energy generated from cotransporting 2 sodium ions with glucose through a symport mechanism. This
945:
for the purpose of glucose uptake into cells. Recently, it has been seen to have functions that can be considered as promising therapeutic target to treat diabetes and obesity. Through the use of the sodium glucose cotransporter 1 protein, cells are able to obtain glucose which is further utilized to
2380:
Roll P, Massacrier A, Pereira S, Robaglia-Schlupp A, Cau P, Szepetowski P (February 2002). "New human sodium/glucose cotransporter gene (KST1): identification, characterization, and mutation analysis in ICCA (infantile convulsions and choreoathetosis) and BFIC (benign familial infantile convulsions)
1062:
The sodium glucose cotransporter is original arranged with an outward-facing conformation with open receptors in preparation for 2 sodium ions and glucose to simultaneously bind. Once bound, the protein receptor will change conformation to an occluded conformation, which prevents the dissociation of
1111:
disease. This is because the mutation destroys the transport function. Glucose-galactose malabsorption occurs when the lining of the intestinal cells cannot take in glucose and galactose which prevents the use of those molecules in catabolism and anabolism. The disease has symptoms that consist of
1076:
Co-transport proteins of mammalian cell membranes had eluded efforts of purification with classical biochemical methods until the late 1980s. These proteins had proven difficult to isolate because they contain hydrophilic and hydrophobic sequences and exist in membranes only in very low abundance
1063:
the sodium ions and glucose. The protein will then change conformations once more to an inward-facing conformation in which allows sodium and glucose to dissociate. The protein then returns to the outward-facing conformation state, ready to bind more sodium ions and glucose.
1077:(<0.2% of membrane proteins). The rabbit form of SGLT1 was the first mammalian co-transport protein ever to be cloned and sequenced, and this was reported in 1987. To circumvent the difficulties with traditional isolation methods, a novel
1116:
which is the result of water retention in the intestinal lumen and osmotic loss created by non-absorbed glucose, galactose and sodium. Patients must stick to a diet devoid of these two sugars, or life-threatening diarrhea will occur.
5582:
2347:"A missense mutation in the Na(+)/glucose cotransporter gene SGLT1 in a patient with congenital glucose-galactose malabsorption: normal trafficking but inactivation of the mutant protein"
1371:"Investigation of SLC6A9 and SLC5A1 as a promising therapeutic target for obesity and diabetes using in silico characterization, 3D structure prediction and molecular docking analysis"
2158:
MartĂn MG, Turk E, Lostao MP, Kerner C, Wright EM (February 1996). "Defects in Na+/glucose cotransporter (SGLT1) trafficking and function cause glucose-galactose malabsorption".
5575:
160:
2480:
1570:
Gorboulev, V.; Schurmann, A.; Vallon, V.; Kipp, H.; Jaschke, A.; Klessen, D.; Friedrich, A.; Scherneck, S.; Rieg, T.; Cunard, R.; Veyhl-Wichmann, M. (2012-01-01).
5568:
1355:
5501:
2129:
Turk E, Klisak I, Bacallao R, Sparkes RS, Wright EM (September 1993). "Assignment of the human Na+/glucose cotransporter gene SGLT1 to chromosome 22q13.1".
3860:
2308:
Obermeier S, HĂĽselweh B, Tinel H, Kinne RH, Kunz C (October 2000). "Expression of glucose transporters in lactating human mammary gland epithelial cells".
1099:
SLC5A1 is medically relevant because of its role in the absorption of glucose and sodium, however, mutations in the gene can cause medical implications. A
2448:
646:
85:
627:
4901:
2096:"The development of Na(+)-dependent glucose transport during differentiation of an intestinal epithelial cell clone is regulated by protein kinase C"
1996:
Turk E, Zabel B, Mundlos S, Dyer J, Wright EM (March 1991). "Glucose/galactose malabsorption caused by a defect in the Na+/glucose cotransporter".
3766:
5296:
4822:
1856:
1230:
1212:
5154:
3022:
2691:
1082:
2458:
4164:
3658:
2584:
2579:
2504:
2473:
146:
1136:
cotransporter is mainly expressed in the lumen of the small intestine, kidney, parotid glands, submandibular glands and in the heart.
1124:. By adding sodium and glucose to water, the co-transporter is allowed to transport all three, helping to speed up water absorption.
5550:
5451:
4618:
3580:
2878:
2792:
2549:
1469:
1331:
1014:
857:
123:
3382:
1299:
3643:
2719:
2564:
1199:
1108:
5491:
3118:
1733:
Hediger MA, Coady MJ, Ikeda TS, Wright EM (1987). "Expression cloning and cDNA sequencing of the Na+/glucose co-transporter".
5844:
5471:
5466:
5437:
3978:
3542:
3344:
3339:
2466:
978:
phosphorylation sites, which serve to regulate the proteins conformational shape through phosphorylation of amino acids with
1195:
3537:
3532:
3527:
3512:
3507:
3502:
3497:
3287:
4863:
4665:
4465:
1572:"Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion"
5819:
5788:
5779:
5643:
5602:
5461:
65:
3453:
4433:
1168:
930:
159:
4312:
4016:
5591:
4385:
2888:
2497:
1029:
gene encodes the sodium glucose cotransporter protein that is involved in the facilitated transport of glucose and
152:
5042:
4698:
3191:
1452:
Avendaño C, Menéndez JC (2008). "Drugs That
Inhibit Signalling Pathways for Tumor Cell Growth and Proliferation".
5446:
3334:
955:
5230:
5496:
3318:
3085:
1121:
689:
73:
5187:
1915:"Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane"
3714:
1485:
Wright EM, Loo DD, Panayotova-Heiermann M, Lostao MP, Hirayama BH, Mackenzie B, et al. (November 1994).
5456:
5088:
2817:
1627:
Hamilton KL, Butt AG (December 2013). "Glucose transport into everted sacs of the small intestine of mice".
979:
970:
residing upon the extracellular side of the plasma membrane. It is hypothesized that the protein contains
5594:
5432:
5268:
4954:
4139:
4064:
3458:
3329:
3324:
2898:
2500:
1145:
1006:
1091:
oocytes to ultimately find the RNA species that induced the expression of sodium-glucose cotransport.
5839:
5529:
5524:
3491:
2893:
2278:
2054:
2005:
1742:
52:
5121:
2827:
2602:
1081:
technique was used. Size-fractionation of large amounts of rabbit intestinal mRNA with preparative
990:
814:
763:
5659:
5769:
2883:
2412:"Up-regulation of sodium-dependent glucose transporter by interaction with heat shock protein 70"
2333:
2183:
2029:
1809:
1766:
1652:
1552:
1349:
1078:
97:
835:
810:
784:
759:
1322:
Lodish H, Berk A, Kaiser CA, Krieger M, Bretscher A, Ploegh H, Amon A, Martin KC (April 2016).
922:
5024:
5019:
4367:
4362:
4289:
4284:
4279:
4274:
4269:
4264:
4244:
4239:
4234:
4229:
4214:
4204:
4194:
4189:
4179:
4154:
3960:
3945:
3940:
3562:
3557:
3552:
2433:
2398:
2368:
2325:
2296:
2253:
2218:
2175:
2146:
2117:
2082:
2043:"Homology of the human intestinal Na+/glucose and Escherichia coli Na+/proline cotransporters"
2021:
1984:
1936:
1895:
1852:
1801:
1758:
1712:
1694:
1644:
1609:
1591:
1544:
1509:
1486:
1465:
1434:
1392:
1337:
1327:
1278:
1100:
45:
5749:
5633:
5278:
5245:
5212:
5202:
5169:
5164:
5098:
4979:
4931:
4921:
4878:
4842:
4837:
4804:
4799:
4794:
4789:
4780:
4775:
4770:
4742:
4732:
4723:
4718:
4713:
4548:
4533:
4528:
4513:
4480:
4447:
4357:
4317:
4074:
4046:
4031:
4026:
4021:
3998:
3993:
3841:
3837:
3828:
3786:
3610:
3600:
3590:
3522:
3468:
3402:
3387:
3221:
3216:
3211:
3062:
2963:
2958:
2928:
2852:
2847:
2842:
2769:
2230:
Lam JT, MartĂn MG, Turk E, Hirayama BA, Bosshard NU, Steinmann B, Wright EM (February 1999).
5744:
5628:
5324:
3425:
3163:
3153:
3138:
3100:
3095:
2913:
2837:
2764:
2489:
2423:
2390:
2358:
2317:
2286:
2243:
2208:
2167:
2138:
2107:
2072:
2062:
2013:
1974:
1926:
1885:
1872:
Sabino-Silva R, Mori RC, David-Silva A, Okamoto MM, Freitas HS, Machado UF (November 2010).
1793:
1784:
Wright EM, Turk E, Martin MG (2002). "Molecular basis for glucose-galactose malabsorption".
1750:
1702:
1686:
1636:
1599:
1583:
1536:
1501:
1457:
1426:
1382:
1268:
994:
975:
971:
397:
239:
170:
114:
93:
5408:
2493:
2265:
Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999).
2232:"Missense mutations in SGLT1 cause glucose-galactose malabsorption by trafficking defects"
934:
214:
5560:
2282:
2058:
2009:
1746:
5714:
5684:
1707:
1674:
1604:
1571:
1461:
1369:
Sinha, Jitendra Kumar; Durgvanshi, Shantanu; Verma, Manish; Ghosh, Shampa (June 2023).
2394:
2363:
2346:
2248:
2231:
2077:
2042:
1300:"Entrez Gene: SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1"
1273:
1256:
561:
556:
551:
546:
541:
536:
531:
526:
510:
505:
500:
495:
490:
485:
480:
475:
459:
454:
449:
444:
439:
5833:
5804:
5759:
5754:
5734:
5719:
5709:
5704:
5699:
5694:
5689:
5679:
5674:
5669:
5664:
5424:
2452:
1107:
gene of exon 1 can cause problems creating the SGLT1 protein, leading to a very rare
1018:
1002:
959:
938:
426:
2337:
1890:
1873:
1813:
1556:
5739:
2187:
2033:
1959:
1770:
1656:
1050:
232:
77:
1846:
1797:
1690:
1527:
Wright EM, Turk E (February 2004). "The sodium/glucose cotransport family SLC5".
5047:
4503:
4099:
3300:
1235:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1217:
National Center for
Biotechnology Information, U.S. National Library of Medicine
2047:
Proceedings of the
National Academy of Sciences of the United States of America
1979:
1827:
1414:
315:
5483:
4641:
1540:
1038:
967:
963:
131:
81:
2112:
2095:
1698:
1640:
1595:
1396:
1341:
5729:
5724:
5623:
5618:
5420:
2067:
1034:
1030:
1022:
1010:
591:
198:
185:
89:
2437:
2428:
2411:
2402:
2372:
2329:
2300:
2257:
2213:
2196:
2142:
1988:
1940:
1931:
1914:
1899:
1805:
1716:
1648:
1613:
1548:
2321:
2222:
2179:
2150:
2121:
2086:
2025:
1762:
1513:
1505:
1438:
1430:
1282:
1120:
In humans without this genetic disorder, SLGT1 is key to the operation of
962:
constructed from the folding of 482-718 amino acid residues with both the
897:
892:
5014:
5009:
5004:
4936:
4553:
4294:
4259:
4254:
4249:
4224:
4219:
4209:
4199:
4184:
4174:
4169:
4159:
4149:
4144:
4134:
4124:
4119:
4114:
3955:
3950:
3935:
3930:
3925:
3920:
3915:
3910:
3680:
3547:
2874:
1960:"The human plasma proteome: history, character, and diagnostic prospects"
1113:
881:
734:
715:
5381:
5376:
5371:
5366:
5361:
5356:
5306:
5301:
5273:
5250:
5240:
5235:
5207:
5197:
5192:
5159:
5103:
5093:
4999:
4994:
4989:
4984:
4974:
4969:
4964:
4959:
4926:
4916:
4911:
4906:
4883:
4873:
4868:
4845:
4832:
4827:
4761:
4756:
4747:
4737:
4708:
4703:
4680:
4675:
4670:
4647:
4623:
4600:
4543:
4538:
4523:
4518:
4508:
4485:
4475:
4470:
4442:
4437:
4415:
4410:
4405:
4400:
4395:
4390:
4352:
4347:
4342:
4337:
4332:
4327:
4322:
4109:
4104:
4094:
4089:
4084:
4079:
4069:
4041:
4036:
3988:
3983:
3905:
3900:
3895:
3890:
3885:
3880:
3875:
3870:
3865:
3823:
3814:
3805:
3800:
3791:
3781:
3776:
3771:
3725:
3720:
3696:
3691:
3686:
3625:
3620:
3615:
3605:
3595:
3585:
3517:
3473:
3463:
3435:
3430:
3407:
3397:
3392:
3364:
3359:
3354:
3349:
3297:
3292:
3248:
3243:
3238:
3233:
3226:
3206:
3201:
3196:
3173:
3168:
3067:
3057:
3052:
2978:
2973:
2968:
2953:
2948:
2943:
2938:
2933:
2774:
2672:
2667:
2662:
2657:
2652:
2171:
1387:
1370:
1087:
998:
942:
917:
701:
658:
1587:
17:
5505:
4594:
4129:
3676:
3158:
3148:
3143:
3133:
3128:
3123:
3090:
3047:
3042:
3037:
3032:
3014:
3009:
3004:
2999:
2923:
2918:
2908:
2903:
2870:
2832:
2822:
2812:
2807:
2797:
2759:
2754:
2749:
2744:
2739:
2734:
2729:
2724:
2701:
2696:
2647:
2637:
2632:
2574:
2569:
2559:
2554:
2017:
1754:
865:
613:
101:
2291:
2266:
1673:
Poulsen, Søren Brandt; Fenton, Robert A.; Rieg, Timo (March 2017).
1041:
cells. The role of the sodium-glucose cotransporter 1 is to absorb
3653:
3648:
2802:
2642:
2627:
2622:
2617:
2612:
2607:
1156:
576:
572:
5136:
5131:
5126:
3027:
2351:
Biochimica et
Biophysica Acta (BBA) - Molecular Basis of Disease
2236:
Biochimica et
Biophysica Acta (BBA) - Molecular Basis of Disease
2197:"Membrane topology of the human Na+/glucose cotransporter SGLT1"
1172:
1150:
1005:. Two families of glucose transporter have been identified: the
926:
69:
5564:
5406:
5345:
5070:
4902:
System A & N, sodium-coupled neutral amino-acid transporter
4576:
3748:
3269:
2531:
2516:
2462:
1848:
Guyton and Hall
Textbook of Medical Physiology: Enhanced E-book
406:
929:
which encodes the production of the SGLT1 protein to line the
1257:"Structure of the human Na+/glucose cotransporter gene SGLT1"
375:
253:
1834:. National Center for Biotechnology Information (US). 1998.
2550:
high affinity glutamate and neutral amino-acid transporter
2345:
Kasahara M, Maeda M, Hayashi S, Mori Y, Abe T (May 2001).
1413:
Wright EM, Hirsch JR, Loo DD, Zampighi GA (January 1997).
1874:"The Na(+)/glucose cotransporters: from genes to therapy"
2996:
cationic amino-acid transporter/glycoprotein-associated
2410:
Ikari A, Nakano M, Kawano K, Suketa Y (September 2002).
2195:
Turk E, Kerner CJ, Lostao MP, Wright EM (January 1996).
1009:
glucose transporter family (GLUT family), also known as
222:
56:, D22S675, NAGT, SGLT1, solute carrier family 5 member 1
3021:
glycoprotein-associated/light or catalytic subunits of
1851:. Philadelphia: Elsevier Health Sciences. p. 330.
1013:, and the sodium-dependent glucose transporter family (
954:
The sodium glucose cotransporter 1 is classified as an
387:
5789:
5780:
5644:
5603:
5155:
Na-independent, system-L like amino-acid transporter
1878:
Brazilian
Journal of Medical and Biological Research
5778:
5642:
5601:
5482:
5419:
5317:
5289:
5261:
5223:
5180:
5147:
5114:
5081:
5035:
4947:
4894:
4856:
4815:
4691:
4658:
4634:
4611:
4587:
4496:
4458:
4426:
4378:
4305:
4057:
4009:
3971:
3853:
3759:
3707:
3669:
3636:
3573:
3484:
3446:
3418:
3375:
3311:
3280:
3184:
3111:
3078:
2989:
2863:
2785:
2712:
2683:
2595:
2542:
828:
803:
777:
752:
1191:
1189:
1187:
169:
2094:Delézay O, Baghdiguian S, Fantini J (May 1995).
1728:
1726:
1679:Current Opinion in Nephrology and Hypertension
1196:GRCm38: Ensembl release 89: ENSMUSG00000011034
5576:
2474:
2041:Hediger MA, Turk E, Wright EM (August 1989).
1250:
1248:
1246:
1244:
8:
3861:organic cation/anion/zwitterion transporter
1054:protein does not use ATP as energy source.
1001:and structurally related substances across
5583:
5569:
5561:
5416:
5403:
5342:
5078:
5067:
4584:
4573:
3756:
3745:
3383:human Na-sulfate/carboxylate cotransporter
3277:
3266:
2539:
2528:
2524:
2513:
2481:
2467:
2459:
2449:United States National Library of Medicine
1958:Anderson NL, Anderson NG (November 2002).
1415:"Regulation of Na+/glucose cotransporters"
1354:: CS1 maint: location missing publisher (
587:
422:
210:
109:
2427:
2362:
2290:
2267:"The DNA sequence of human chromosome 22"
2247:
2212:
2111:
2076:
2066:
1978:
1930:
1889:
1845:Guyton, A.C.; Hall, J.E. (19 July 2010).
1706:
1603:
1386:
1272:
1255:Turk E, MartĂn MG, Wright EM (May 1994).
2447:This article incorporates text from the
1487:"'Active' sugar transport in eukaryotes"
1294:
1292:
3979:Na+-dependent ascorbic acid transporter
1454:Medicinal Chemistry of Anticancer Drugs
1183:
3767:Organic anion-transporting polypeptide
1347:
362:crypt of lieberkuhn of small intestine
26:
4823:proton-coupled amino-acid transporter
3023:heterodimeric amino-acid transporters
2692:heterodimeric amino-acid transporters
1668:
1666:
1085:were then sequentially injected into
496:integral component of plasma membrane
174:
135:
130:
7:
5794:Tooltip Sodium-glucose transporter 2
5785:Tooltip Sodium-glucose transporter 1
5649:Tooltip Sodium-glucose transporter 2
5608:Tooltip Sodium-glucose transporter 1
3288:proton coupled metal ion transporter
1832:Genes and Disease [Internet]
1408:
1406:
1317:
1315:
1313:
1311:
1309:
946:make and store energy for the cell.
4864:sugar-phosphate/phosphate exchanger
4466:facilitative nucleoside transporter
2416:The Journal of Biological Chemistry
2201:The Journal of Biological Chemistry
2100:The Journal of Biological Chemistry
1967:Molecular & Cellular Proteomics
1919:The Journal of Biological Chemistry
1494:The Journal of Experimental Biology
1419:The Journal of Experimental Biology
1261:The Journal of Biological Chemistry
4666:type II Na-phosphate cotransporter
2879:sodium:neurotransmitter symporters
1462:10.1016/b978-0-444-52824-7.00009-3
825:
800:
774:
749:
725:
706:
680:
663:
637:
618:
460:transmembrane transporter activity
392:
310:
248:
227:
25:
4619:Vesicular glutamate transporter 1
3581:Vesicular glutamate transporter 1
3454:proton oligopeptide cotransporter
1828:"Glucose galactose malabsorption"
920:in humans that is encoded by the
455:glucose:sodium symporter activity
1786:Cell Biochemistry and Biophysics
1629:Advances in Physiology Education
937:and the epithelial cells of the
914:solute carrier family 5 member 1
396:
158:
151:
145:
122:
4434:Na-coupled nucleoside transport
4313:multifunctional anion exchanger
3644:vesicular monoamine transporter
1891:10.1590/S0100-879X2010007500115
1109:glucose-galactose malabsorption
552:intestinal D-glucose absorption
527:glucose transmembrane transport
1456:. Elsevier. pp. 251–305.
997:that mediate the transport of
910:Sodium/glucose cotransporter 1
476:integral component of membrane
407:More reference expression data
376:More reference expression data
1:
5820:Receptor/signaling modulators
5297:multidrug and toxin extrusion
4386:fatty acid transport proteins
2603:facilitative GLUT transporter
2395:10.1016/S0378-1119(02)00416-X
2364:10.1016/s0925-4439(01)00043-6
2310:European Journal of Nutrition
2249:10.1016/s0925-4439(98)00109-4
1326:(Eighth ed.). New York.
1274:10.1016/S0021-9258(17)36592-4
338:epithelium of small intestine
143:
5043:basolateral iron transporter
4699:nucleoside-sugar transporter
3192:sodium bile salt cotransport
2793:sodium glucose cotransporter
1691:10.1097/MNH.0000000000000152
1675:"Sodium-glucose cotransport"
557:intestinal hexose absorption
5767:Antisense oligonucleotides:
2498:membrane transport proteins
5861:
5592:Sodium-glucose transporter
5231:Putative sugar transporter
1980:10.1074/mcp.R200007-MCP200
1913:Xie J, Guo Q (July 2004).
1375:Alzheimer's & Dementia
5813:
5546:
5415:
5402:
5352:
5341:
5077:
5066:
4583:
4572:
3755:
3744:
3276:
3265:
2538:
2527:
2523:
2512:
1541:10.1007/s00424-003-1063-6
1231:"Mouse PubMed Reference:"
1213:"Human PubMed Reference:"
1167:SLC5A1 has been shown to
956:integral membrane protein
896:
891:
887:
880:
864:
847:
832:
807:
796:
781:
756:
745:
732:
728:
713:
709:
700:
687:
683:
670:
666:
657:
644:
640:
625:
621:
612:
597:
590:
586:
570:
425:
421:
404:
395:
386:
373:
322:
313:
260:
251:
221:
213:
209:
192:
179:
142:
121:
112:
108:
63:
60:
50:
43:
38:
34:
29:
5551:solute carrier disorders
5188:Choline-like transporter
3319:electroneutral cation-Cl
2113:10.1074/jbc.270.21.12536
1641:10.1152/advan.00017.2013
1122:oral rehydration therapy
5089:Magnesium transporter E
2720:bicarbonate transporter
2068:10.1073/pnas.86.15.5748
858:Chr 5: 33.26 – 33.32 Mb
547:transmembrane transport
5484:Antiporter (exchanger)
2429:10.1074/jbc.M200310200
2214:10.1074/jbc.271.4.1925
2143:10.1006/geno.1993.1399
1932:10.1074/jbc.M401495200
1798:10.1385/CBB:36:2-3:115
1324:Molecular cell biology
958:that is made up of 14
912:(SGLT1) also known as
542:carbohydrate transport
506:apical plasma membrane
284:pancreatic ductal cell
5845:Solute carrier family
4955:metal ion transporter
4065:mitochondrial carrier
3715:type III Na-phosphate
2322:10.1007/s003940070011
1506:10.1242/jeb.196.1.197
1431:10.1242/jeb.200.2.287
1146:Solute carrier family
1112:watery and/or acidic
1095:Clinical significance
1007:facilitated diffusion
511:extracellular exosome
501:brush border membrane
296:minor salivary glands
1049:-galactose from the
991:Glucose transporters
532:sodium ion transport
440:transporter activity
137:Chromosome 5 (mouse)
5122:Ammonia transporter
4017:Na/(Ca-K) exchanger
2283:1999Natur.402..489D
2059:1989PNAS...86.5748H
2010:1991Natur.350..354T
1747:1987Natur.330..379H
1128:Tissue distribution
1083:gel electrophoresis
1058:Transport mechanism
292:islet of Langerhans
5269:Folate transporter
2690:heavy subunits of
2451:, which is in the
2172:10.1038/ng0296-216
1388:10.1002/alz.064229
1079:expression cloning
1003:cellular membranes
690:ENSMUSG00000011034
520:Biological process
486:cell-cell junction
469:Cellular component
450:symporter activity
433:Molecular function
102:SLC5A1 - orthologs
5827:
5826:
5558:
5557:
5542:
5541:
5538:
5537:
5398:
5397:
5394:
5393:
5390:
5389:
5337:
5336:
5333:
5332:
5062:
5061:
5058:
5057:
4568:
4567:
4564:
4563:
3740:
3739:
3736:
3735:
3261:
3260:
3257:
3256:
2490:Membrane proteins
1858:978-0-7216-0240-0
1588:10.2337/db11-1029
1101:missense mutation
1048:
1044:
1017:), also known as
995:membrane proteins
907:
906:
903:
902:
876:
875:
843:
842:
822:
821:
792:
791:
771:
770:
741:
740:
722:
721:
696:
695:
677:
676:
653:
652:
634:
633:
582:
581:
417:
416:
413:
412:
382:
381:
369:
368:
334:intestinal villus
307:
306:
205:
204:
16:(Redirected from
5852:
5795:
5791:
5786:
5782:
5650:
5646:
5609:
5605:
5585:
5578:
5571:
5562:
5517:
5516:
5515:
5417:
5404:
5343:
5325:Heme transporter
5079:
5068:
4585:
4574:
3757:
3746:
3426:urea transporter
3278:
3267:
2540:
2529:
2525:
2514:
2494:carrier proteins
2483:
2476:
2469:
2460:
2441:
2431:
2422:(36): 33338–43.
2406:
2376:
2366:
2341:
2304:
2294:
2277:(6761): 489–95.
2261:
2251:
2226:
2216:
2191:
2154:
2125:
2115:
2106:(21): 12536–41.
2090:
2080:
2070:
2037:
2018:10.1038/350354a0
1992:
1982:
1964:
1945:
1944:
1934:
1925:(27): 28266–75.
1910:
1904:
1903:
1893:
1869:
1863:
1862:
1842:
1836:
1835:
1824:
1818:
1817:
1781:
1775:
1774:
1755:10.1038/330379a0
1741:(6146): 379–81.
1730:
1721:
1720:
1710:
1670:
1661:
1660:
1624:
1618:
1617:
1607:
1567:
1561:
1560:
1524:
1518:
1517:
1491:
1482:
1476:
1475:
1449:
1443:
1442:
1425:(Pt 2): 287–93.
1410:
1401:
1400:
1390:
1366:
1360:
1359:
1353:
1345:
1319:
1304:
1303:
1296:
1287:
1286:
1276:
1252:
1239:
1238:
1227:
1221:
1220:
1209:
1203:
1193:
1046:
1042:
976:protein kinase C
972:protein kinase A
931:absorptive cells
889:
888:
860:
853:
838:
826:
817:
801:
797:RefSeq (protein)
787:
775:
766:
750:
726:
707:
681:
664:
638:
619:
588:
423:
409:
400:
393:
378:
346:Ileal epithelium
318:
316:Top expressed in
311:
256:
254:Top expressed in
249:
228:
211:
201:
188:
177:
162:
155:
149:
138:
126:
110:
104:
55:
48:
27:
21:
5860:
5859:
5855:
5854:
5853:
5851:
5850:
5849:
5830:
5829:
5828:
5823:
5809:
5793:
5784:
5774:
5648:
5638:
5607:
5597:
5589:
5559:
5554:
5534:
5514:
5511:
5510:
5509:
5507:
5478:
5441:
5411:
5386:
5348:
5329:
5313:
5285:
5257:
5219:
5176:
5143:
5110:
5073:
5054:
5031:
4943:
4890:
4852:
4811:
4687:
4654:
4630:
4607:
4579:
4560:
4492:
4454:
4422:
4374:
4301:
4053:
4005:
3967:
3849:
3751:
3732:
3703:
3665:
3632:
3569:
3492:monocarboxylate
3480:
3442:
3414:
3371:
3307:
3272:
3253:
3180:
3107:
3086:Na/Ca exchanger
3074:
2985:
2859:
2781:
2708:
2679:
2591:
2534:
2519:
2508:
2487:
2444:
2409:
2379:
2344:
2307:
2264:
2229:
2194:
2160:Nature Genetics
2157:
2128:
2093:
2053:(15): 5748–52.
2040:
2004:(6316): 354–6.
1995:
1962:
1957:
1953:
1951:Further reading
1948:
1912:
1911:
1907:
1884:(11): 1019–26.
1871:
1870:
1866:
1859:
1844:
1843:
1839:
1826:
1825:
1821:
1792:(2–3): 115–21.
1783:
1782:
1778:
1732:
1731:
1724:
1672:
1671:
1664:
1626:
1625:
1621:
1569:
1568:
1564:
1529:PflĂĽgers Archiv
1526:
1525:
1521:
1489:
1484:
1483:
1479:
1472:
1451:
1450:
1446:
1412:
1411:
1404:
1368:
1367:
1363:
1346:
1334:
1321:
1320:
1307:
1298:
1297:
1290:
1267:(21): 15204–9.
1254:
1253:
1242:
1229:
1228:
1224:
1211:
1210:
1206:
1194:
1185:
1181:
1165:
1142:
1130:
1097:
1074:
1069:
1060:
988:
952:
935:small intestine
898:View/Edit Mouse
893:View/Edit Human
856:
851:
848:Location (UCSC)
834:
813:
809:
783:
762:
758:
566:
515:
491:plasma membrane
464:
445:protein binding
405:
374:
365:
360:
356:
352:
348:
344:
340:
336:
332:
328:
314:
303:
298:
294:
290:
288:skin of abdomen
286:
282:
280:right ventricle
278:
274:
270:
266:
252:
196:
183:
175:
165:
164:
163:
156:
136:
113:Gene location (
64:
51:
44:
23:
22:
15:
12:
11:
5:
5858:
5856:
5848:
5847:
5842:
5832:
5831:
5825:
5824:
5814:
5811:
5810:
5808:
5807:
5798:
5796:
5776:
5775:
5773:
5772:
5763:
5762:
5757:
5752:
5747:
5742:
5737:
5732:
5727:
5722:
5717:
5715:Luseogliflozin
5712:
5707:
5702:
5697:
5692:
5687:
5685:Enavogliflozin
5682:
5677:
5672:
5667:
5662:
5653:
5651:
5640:
5639:
5637:
5636:
5631:
5626:
5621:
5612:
5610:
5599:
5598:
5590:
5588:
5587:
5580:
5573:
5565:
5556:
5555:
5547:
5544:
5543:
5540:
5539:
5536:
5535:
5533:
5532:
5527:
5522:
5521:
5520:
5512:
5494:
5488:
5486:
5480:
5479:
5477:
5476:
5475:
5474:
5469:
5459:
5454:
5449:
5444:
5439:
5435:
5429:
5427:
5413:
5412:
5407:
5400:
5399:
5396:
5395:
5392:
5391:
5388:
5387:
5385:
5384:
5379:
5374:
5369:
5364:
5359:
5353:
5350:
5349:
5346:
5339:
5338:
5335:
5334:
5331:
5330:
5328:
5327:
5321:
5319:
5315:
5314:
5312:
5311:
5310:
5309:
5304:
5293:
5291:
5287:
5286:
5284:
5283:
5282:
5281:
5276:
5265:
5263:
5259:
5258:
5256:
5255:
5254:
5253:
5248:
5243:
5238:
5227:
5225:
5221:
5220:
5218:
5217:
5216:
5215:
5210:
5205:
5200:
5195:
5184:
5182:
5178:
5177:
5175:
5174:
5173:
5172:
5167:
5162:
5151:
5149:
5145:
5144:
5142:
5141:
5140:
5139:
5134:
5129:
5118:
5116:
5112:
5111:
5109:
5108:
5107:
5106:
5101:
5096:
5085:
5083:
5075:
5074:
5071:
5064:
5063:
5060:
5059:
5056:
5055:
5053:
5052:
5051:
5050:
5039:
5037:
5033:
5032:
5030:
5029:
5028:
5027:
5022:
5017:
5012:
5007:
5002:
4997:
4992:
4987:
4982:
4977:
4972:
4967:
4962:
4951:
4949:
4945:
4944:
4942:
4941:
4940:
4939:
4934:
4929:
4924:
4919:
4914:
4909:
4898:
4896:
4892:
4891:
4889:
4888:
4887:
4886:
4881:
4876:
4871:
4860:
4858:
4854:
4853:
4851:
4850:
4849:
4848:
4840:
4835:
4830:
4819:
4817:
4813:
4812:
4810:
4809:
4808:
4807:
4802:
4797:
4792:
4785:
4784:
4783:
4778:
4773:
4766:
4765:
4764:
4759:
4752:
4751:
4750:
4745:
4740:
4735:
4728:
4727:
4726:
4721:
4716:
4711:
4706:
4695:
4693:
4689:
4688:
4686:
4685:
4684:
4683:
4678:
4673:
4662:
4660:
4656:
4655:
4653:
4652:
4651:
4650:
4638:
4636:
4632:
4631:
4629:
4628:
4627:
4626:
4615:
4613:
4609:
4608:
4606:
4605:
4604:
4603:
4591:
4589:
4581:
4580:
4577:
4570:
4569:
4566:
4565:
4562:
4561:
4559:
4558:
4557:
4556:
4551:
4546:
4541:
4536:
4531:
4526:
4521:
4516:
4511:
4500:
4498:
4494:
4493:
4491:
4490:
4489:
4488:
4483:
4478:
4473:
4462:
4460:
4456:
4455:
4453:
4452:
4451:
4450:
4445:
4430:
4428:
4424:
4423:
4421:
4420:
4419:
4418:
4413:
4408:
4403:
4398:
4393:
4382:
4380:
4376:
4375:
4373:
4372:
4371:
4370:
4365:
4360:
4355:
4350:
4345:
4340:
4335:
4330:
4325:
4320:
4309:
4307:
4303:
4302:
4300:
4299:
4298:
4297:
4292:
4287:
4282:
4277:
4272:
4267:
4262:
4257:
4252:
4247:
4242:
4237:
4232:
4227:
4222:
4217:
4212:
4207:
4202:
4197:
4192:
4187:
4182:
4177:
4172:
4167:
4162:
4157:
4152:
4147:
4142:
4137:
4132:
4127:
4122:
4117:
4112:
4107:
4102:
4097:
4092:
4087:
4082:
4077:
4072:
4061:
4059:
4055:
4054:
4052:
4051:
4050:
4049:
4044:
4039:
4034:
4029:
4024:
4013:
4011:
4007:
4006:
4004:
4003:
4002:
4001:
3996:
3991:
3986:
3975:
3973:
3969:
3968:
3966:
3965:
3964:
3963:
3958:
3953:
3948:
3943:
3938:
3933:
3928:
3923:
3918:
3913:
3908:
3903:
3898:
3893:
3888:
3883:
3878:
3873:
3868:
3857:
3855:
3851:
3850:
3848:
3847:
3846:
3845:
3833:
3832:
3831:
3826:
3819:
3818:
3817:
3810:
3809:
3808:
3803:
3796:
3795:
3794:
3789:
3784:
3779:
3774:
3763:
3761:
3753:
3752:
3749:
3742:
3741:
3738:
3737:
3734:
3733:
3731:
3730:
3729:
3728:
3723:
3717:cotransporter
3711:
3709:
3705:
3704:
3702:
3701:
3700:
3699:
3694:
3689:
3673:
3671:
3667:
3666:
3664:
3663:
3662:
3661:
3656:
3651:
3640:
3638:
3634:
3633:
3631:
3630:
3629:
3628:
3623:
3618:
3613:
3608:
3603:
3598:
3593:
3588:
3577:
3575:
3571:
3570:
3568:
3567:
3566:
3565:
3560:
3555:
3550:
3545:
3540:
3535:
3530:
3525:
3520:
3515:
3510:
3505:
3500:
3488:
3486:
3482:
3481:
3479:
3478:
3477:
3476:
3471:
3466:
3461:
3450:
3448:
3444:
3443:
3441:
3440:
3439:
3438:
3433:
3422:
3420:
3416:
3415:
3413:
3412:
3411:
3410:
3405:
3400:
3395:
3390:
3379:
3377:
3373:
3372:
3370:
3369:
3368:
3367:
3362:
3357:
3352:
3347:
3342:
3337:
3332:
3327:
3321:cotransporter
3315:
3313:
3309:
3308:
3306:
3305:
3304:
3303:
3295:
3284:
3282:
3274:
3273:
3270:
3263:
3262:
3259:
3258:
3255:
3254:
3252:
3251:
3246:
3241:
3236:
3231:
3230:
3229:
3224:
3219:
3214:
3209:
3204:
3199:
3188:
3186:
3182:
3181:
3179:
3178:
3177:
3176:
3171:
3166:
3161:
3156:
3151:
3146:
3141:
3136:
3131:
3126:
3119:Na/H exchanger
3115:
3113:
3109:
3108:
3106:
3105:
3104:
3103:
3098:
3093:
3082:
3080:
3076:
3075:
3073:
3072:
3071:
3070:
3065:
3060:
3055:
3050:
3045:
3040:
3035:
3030:
3019:
3018:
3017:
3012:
3007:
3002:
2993:
2991:
2987:
2986:
2984:
2983:
2982:
2981:
2976:
2971:
2966:
2961:
2956:
2951:
2946:
2941:
2936:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2886:
2867:
2865:
2861:
2860:
2858:
2857:
2856:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2789:
2787:
2783:
2782:
2780:
2779:
2778:
2777:
2772:
2767:
2762:
2757:
2752:
2747:
2742:
2737:
2732:
2727:
2716:
2714:
2710:
2709:
2707:
2706:
2705:
2704:
2699:
2687:
2685:
2681:
2680:
2678:
2677:
2676:
2675:
2670:
2665:
2660:
2655:
2650:
2645:
2640:
2635:
2630:
2625:
2620:
2615:
2610:
2599:
2597:
2593:
2592:
2590:
2589:
2588:
2587:
2582:
2577:
2572:
2567:
2562:
2557:
2546:
2544:
2536:
2535:
2532:
2521:
2520:
2517:
2510:
2509:
2501:solute carrier
2488:
2486:
2485:
2478:
2471:
2463:
2443:
2442:
2407:
2389:(1–2): 141–8.
2377:
2357:(2–3): 141–7.
2342:
2316:(5): 194–200.
2305:
2292:10.1038/990031
2262:
2242:(2): 297–303.
2227:
2207:(4): 1925–34.
2192:
2155:
2126:
2091:
2038:
1993:
1973:(11): 845–67.
1954:
1952:
1949:
1947:
1946:
1905:
1864:
1857:
1837:
1819:
1776:
1722:
1685:(5): 463–469.
1662:
1619:
1582:(1): 187–196.
1562:
1519:
1477:
1470:
1444:
1402:
1361:
1332:
1305:
1288:
1240:
1222:
1204:
1182:
1180:
1177:
1164:
1161:
1160:
1159:
1154:
1148:
1141:
1138:
1129:
1126:
1096:
1093:
1073:
1070:
1068:
1065:
1059:
1056:
1019:cotransporters
987:
984:
951:
948:
939:kidney tubules
905:
904:
901:
900:
895:
885:
884:
878:
877:
874:
873:
871:
869:
862:
861:
854:
849:
845:
844:
841:
840:
830:
829:
823:
820:
819:
805:
804:
798:
794:
793:
790:
789:
779:
778:
772:
769:
768:
754:
753:
747:
743:
742:
739:
738:
730:
729:
723:
720:
719:
711:
710:
704:
698:
697:
694:
693:
685:
684:
678:
675:
674:
668:
667:
661:
655:
654:
651:
650:
642:
641:
635:
632:
631:
623:
622:
616:
610:
609:
604:
599:
595:
594:
584:
583:
580:
579:
568:
567:
565:
564:
559:
554:
549:
544:
539:
534:
529:
523:
521:
517:
516:
514:
513:
508:
503:
498:
493:
488:
483:
478:
472:
470:
466:
465:
463:
462:
457:
452:
447:
442:
436:
434:
430:
429:
419:
418:
415:
414:
411:
410:
402:
401:
390:
384:
383:
380:
379:
371:
370:
367:
366:
364:
363:
359:
355:
351:
347:
343:
339:
335:
331:
327:
323:
320:
319:
308:
305:
304:
302:
301:
297:
293:
289:
285:
281:
277:
273:
272:left ventricle
269:
265:
264:jejunal mucosa
261:
258:
257:
245:
244:
236:
225:
219:
218:
215:RNA expression
207:
206:
203:
202:
194:
190:
189:
181:
178:
173:
167:
166:
157:
150:
144:
140:
139:
134:
128:
127:
119:
118:
106:
105:
62:
58:
57:
49:
41:
40:
36:
35:
32:
31:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5857:
5846:
5843:
5841:
5838:
5837:
5835:
5822:
5821:
5818:
5812:
5806:
5805:Sotagliflozin
5803:
5800:
5799:
5797:
5792:
5783:
5777:
5771:
5768:
5765:
5764:
5761:
5760:Velagliflozin
5758:
5756:
5755:Tofogliflozin
5753:
5751:
5748:
5746:
5743:
5741:
5738:
5736:
5735:Remogliflozin
5733:
5731:
5728:
5726:
5723:
5721:
5720:Mizagliflozin
5718:
5716:
5713:
5711:
5710:Licogliflozin
5708:
5706:
5705:Janagliflozin
5703:
5701:
5700:Ipragliflozin
5698:
5696:
5695:Henagliflozin
5693:
5691:
5690:Ertugliflozin
5688:
5686:
5683:
5681:
5680:Empagliflozin
5678:
5676:
5675:Dapagliflozin
5673:
5671:
5670:Canagliflozin
5668:
5666:
5665:Bexagliflozin
5663:
5661:
5658:
5655:
5654:
5652:
5647:
5641:
5635:
5632:
5630:
5627:
5625:
5622:
5620:
5617:
5614:
5613:
5611:
5606:
5600:
5596:
5593:
5586:
5581:
5579:
5574:
5572:
5567:
5566:
5563:
5553:
5552:
5545:
5531:
5528:
5526:
5523:
5519:
5503:
5500:
5499:
5498:
5495:
5493:
5490:
5489:
5487:
5485:
5481:
5473:
5470:
5468:
5465:
5464:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5443:
5436:
5434:
5431:
5430:
5428:
5426:
5425:Cotransporter
5422:
5418:
5414:
5410:
5405:
5401:
5383:
5380:
5378:
5375:
5373:
5370:
5368:
5365:
5363:
5360:
5358:
5355:
5354:
5351:
5344:
5340:
5326:
5323:
5322:
5320:
5316:
5308:
5305:
5303:
5300:
5299:
5298:
5295:
5294:
5292:
5288:
5280:
5277:
5275:
5272:
5271:
5270:
5267:
5266:
5264:
5260:
5252:
5249:
5247:
5244:
5242:
5239:
5237:
5234:
5233:
5232:
5229:
5228:
5226:
5222:
5214:
5211:
5209:
5206:
5204:
5201:
5199:
5196:
5194:
5191:
5190:
5189:
5186:
5185:
5183:
5179:
5171:
5168:
5166:
5163:
5161:
5158:
5157:
5156:
5153:
5152:
5150:
5146:
5138:
5135:
5133:
5130:
5128:
5125:
5124:
5123:
5120:
5119:
5117:
5113:
5105:
5102:
5100:
5097:
5095:
5092:
5091:
5090:
5087:
5086:
5084:
5080:
5076:
5069:
5065:
5049:
5046:
5045:
5044:
5041:
5040:
5038:
5034:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4981:
4978:
4976:
4973:
4971:
4968:
4966:
4963:
4961:
4958:
4957:
4956:
4953:
4952:
4950:
4946:
4938:
4935:
4933:
4930:
4928:
4925:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4904:
4903:
4900:
4899:
4897:
4893:
4885:
4882:
4880:
4877:
4875:
4872:
4870:
4867:
4866:
4865:
4862:
4861:
4859:
4855:
4847:
4844:
4841:
4839:
4836:
4834:
4831:
4829:
4826:
4825:
4824:
4821:
4820:
4818:
4814:
4806:
4803:
4801:
4798:
4796:
4793:
4791:
4788:
4787:
4786:
4782:
4779:
4777:
4774:
4772:
4769:
4768:
4767:
4763:
4760:
4758:
4755:
4754:
4753:
4749:
4746:
4744:
4741:
4739:
4736:
4734:
4731:
4730:
4729:
4725:
4722:
4720:
4717:
4715:
4712:
4710:
4707:
4705:
4702:
4701:
4700:
4697:
4696:
4694:
4690:
4682:
4679:
4677:
4674:
4672:
4669:
4668:
4667:
4664:
4663:
4661:
4657:
4649:
4646:
4645:
4643:
4640:
4639:
4637:
4633:
4625:
4622:
4621:
4620:
4617:
4616:
4614:
4610:
4602:
4599:
4598:
4596:
4593:
4592:
4590:
4586:
4582:
4575:
4571:
4555:
4552:
4550:
4547:
4545:
4542:
4540:
4537:
4535:
4532:
4530:
4527:
4525:
4522:
4520:
4517:
4515:
4512:
4510:
4507:
4506:
4505:
4502:
4501:
4499:
4495:
4487:
4484:
4482:
4479:
4477:
4474:
4472:
4469:
4468:
4467:
4464:
4463:
4461:
4457:
4449:
4446:
4444:
4441:
4440:
4439:
4435:
4432:
4431:
4429:
4425:
4417:
4414:
4412:
4409:
4407:
4404:
4402:
4399:
4397:
4394:
4392:
4389:
4388:
4387:
4384:
4383:
4381:
4377:
4369:
4366:
4364:
4361:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4339:
4336:
4334:
4331:
4329:
4326:
4324:
4321:
4319:
4316:
4315:
4314:
4311:
4310:
4308:
4304:
4296:
4293:
4291:
4288:
4286:
4283:
4281:
4278:
4276:
4273:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4241:
4238:
4236:
4233:
4231:
4228:
4226:
4223:
4221:
4218:
4216:
4213:
4211:
4208:
4206:
4203:
4201:
4198:
4196:
4193:
4191:
4188:
4186:
4183:
4181:
4178:
4176:
4173:
4171:
4168:
4166:
4163:
4161:
4158:
4156:
4153:
4151:
4148:
4146:
4143:
4141:
4138:
4136:
4133:
4131:
4128:
4126:
4123:
4121:
4118:
4116:
4113:
4111:
4108:
4106:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4086:
4083:
4081:
4078:
4076:
4073:
4071:
4068:
4067:
4066:
4063:
4062:
4060:
4056:
4048:
4045:
4043:
4040:
4038:
4035:
4033:
4030:
4028:
4025:
4023:
4020:
4019:
4018:
4015:
4014:
4012:
4008:
4000:
3997:
3995:
3992:
3990:
3987:
3985:
3982:
3981:
3980:
3977:
3976:
3974:
3970:
3962:
3959:
3957:
3954:
3952:
3949:
3947:
3944:
3942:
3939:
3937:
3934:
3932:
3929:
3927:
3924:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3892:
3889:
3887:
3884:
3882:
3879:
3877:
3874:
3872:
3869:
3867:
3864:
3863:
3862:
3859:
3858:
3856:
3852:
3843:
3839:
3836:
3835:
3834:
3830:
3827:
3825:
3822:
3821:
3820:
3816:
3813:
3812:
3811:
3807:
3804:
3802:
3799:
3798:
3797:
3793:
3790:
3788:
3785:
3783:
3780:
3778:
3775:
3773:
3770:
3769:
3768:
3765:
3764:
3762:
3758:
3754:
3747:
3743:
3727:
3724:
3722:
3719:
3718:
3716:
3713:
3712:
3710:
3706:
3698:
3695:
3693:
3690:
3688:
3685:
3684:
3682:
3678:
3675:
3674:
3672:
3668:
3660:
3657:
3655:
3652:
3650:
3647:
3646:
3645:
3642:
3641:
3639:
3635:
3627:
3624:
3622:
3619:
3617:
3614:
3612:
3609:
3607:
3604:
3602:
3599:
3597:
3594:
3592:
3589:
3587:
3584:
3583:
3582:
3579:
3578:
3576:
3572:
3564:
3561:
3559:
3556:
3554:
3551:
3549:
3546:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3495:
3493:
3490:
3489:
3487:
3483:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3456:
3455:
3452:
3451:
3449:
3445:
3437:
3434:
3432:
3429:
3428:
3427:
3424:
3423:
3421:
3417:
3409:
3406:
3404:
3401:
3399:
3396:
3394:
3391:
3389:
3386:
3385:
3384:
3381:
3380:
3378:
3374:
3366:
3363:
3361:
3358:
3356:
3353:
3351:
3348:
3346:
3343:
3341:
3338:
3336:
3333:
3331:
3328:
3326:
3323:
3322:
3320:
3317:
3316:
3314:
3310:
3302:
3299:
3296:
3294:
3291:
3290:
3289:
3286:
3285:
3283:
3279:
3275:
3268:
3264:
3250:
3247:
3245:
3242:
3240:
3237:
3235:
3232:
3228:
3225:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3194:
3193:
3190:
3189:
3187:
3183:
3175:
3172:
3170:
3167:
3165:
3162:
3160:
3157:
3155:
3152:
3150:
3147:
3145:
3142:
3140:
3137:
3135:
3132:
3130:
3127:
3125:
3122:
3121:
3120:
3117:
3116:
3114:
3110:
3102:
3099:
3097:
3094:
3092:
3089:
3088:
3087:
3084:
3083:
3081:
3077:
3069:
3066:
3064:
3061:
3059:
3056:
3054:
3051:
3049:
3046:
3044:
3041:
3039:
3036:
3034:
3031:
3029:
3026:
3025:
3024:
3020:
3016:
3013:
3011:
3008:
3006:
3003:
3001:
2998:
2997:
2995:
2994:
2992:
2988:
2980:
2977:
2975:
2972:
2970:
2967:
2965:
2962:
2960:
2957:
2955:
2952:
2950:
2947:
2945:
2942:
2940:
2937:
2935:
2932:
2930:
2927:
2925:
2922:
2920:
2917:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2885:
2882:
2881:
2880:
2876:
2872:
2869:
2868:
2866:
2862:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2795:
2794:
2791:
2790:
2788:
2784:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2726:
2723:
2722:
2721:
2718:
2717:
2715:
2711:
2703:
2700:
2698:
2695:
2694:
2693:
2689:
2688:
2686:
2682:
2674:
2671:
2669:
2666:
2664:
2661:
2659:
2656:
2654:
2651:
2649:
2646:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2605:
2604:
2601:
2600:
2598:
2594:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2552:
2551:
2548:
2547:
2545:
2541:
2537:
2530:
2526:
2522:
2515:
2511:
2506:
2502:
2499:
2495:
2491:
2484:
2479:
2477:
2472:
2470:
2465:
2464:
2461:
2457:
2456:
2454:
2453:public domain
2450:
2439:
2435:
2430:
2425:
2421:
2417:
2413:
2408:
2404:
2400:
2396:
2392:
2388:
2384:
2378:
2374:
2370:
2365:
2360:
2356:
2352:
2348:
2343:
2339:
2335:
2331:
2327:
2323:
2319:
2315:
2311:
2306:
2302:
2298:
2293:
2288:
2284:
2280:
2276:
2272:
2268:
2263:
2259:
2255:
2250:
2245:
2241:
2237:
2233:
2228:
2224:
2220:
2215:
2210:
2206:
2202:
2198:
2193:
2189:
2185:
2181:
2177:
2173:
2169:
2166:(2): 216–20.
2165:
2161:
2156:
2152:
2148:
2144:
2140:
2136:
2132:
2127:
2123:
2119:
2114:
2109:
2105:
2101:
2097:
2092:
2088:
2084:
2079:
2074:
2069:
2064:
2060:
2056:
2052:
2048:
2044:
2039:
2035:
2031:
2027:
2023:
2019:
2015:
2011:
2007:
2003:
1999:
1994:
1990:
1986:
1981:
1976:
1972:
1968:
1961:
1956:
1955:
1950:
1942:
1938:
1933:
1928:
1924:
1920:
1916:
1909:
1906:
1901:
1897:
1892:
1887:
1883:
1879:
1875:
1868:
1865:
1860:
1854:
1850:
1849:
1841:
1838:
1833:
1829:
1823:
1820:
1815:
1811:
1807:
1803:
1799:
1795:
1791:
1787:
1780:
1777:
1772:
1768:
1764:
1760:
1756:
1752:
1748:
1744:
1740:
1736:
1729:
1727:
1723:
1718:
1714:
1709:
1704:
1700:
1696:
1692:
1688:
1684:
1680:
1676:
1669:
1667:
1663:
1658:
1654:
1650:
1646:
1642:
1638:
1635:(4): 415–26.
1634:
1630:
1623:
1620:
1615:
1611:
1606:
1601:
1597:
1593:
1589:
1585:
1581:
1577:
1573:
1566:
1563:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1530:
1523:
1520:
1515:
1511:
1507:
1503:
1499:
1495:
1488:
1481:
1478:
1473:
1471:9780444528247
1467:
1463:
1459:
1455:
1448:
1445:
1440:
1436:
1432:
1428:
1424:
1420:
1416:
1409:
1407:
1403:
1398:
1394:
1389:
1384:
1380:
1376:
1372:
1365:
1362:
1357:
1351:
1343:
1339:
1335:
1333:9781464183393
1329:
1325:
1318:
1316:
1314:
1312:
1310:
1306:
1301:
1295:
1293:
1289:
1284:
1280:
1275:
1270:
1266:
1262:
1258:
1251:
1249:
1247:
1245:
1241:
1236:
1232:
1226:
1223:
1218:
1214:
1208:
1205:
1201:
1197:
1192:
1190:
1188:
1184:
1178:
1176:
1174:
1170:
1162:
1158:
1155:
1152:
1149:
1147:
1144:
1143:
1139:
1137:
1135:
1127:
1125:
1123:
1118:
1115:
1110:
1106:
1102:
1094:
1092:
1090:
1089:
1084:
1080:
1071:
1066:
1064:
1057:
1055:
1052:
1045:-glucose and
1040:
1036:
1032:
1028:
1024:
1020:
1016:
1012:
1008:
1004:
1000:
996:
993:are integral
992:
985:
983:
981:
977:
973:
969:
965:
961:
960:alpha-helices
957:
949:
947:
944:
940:
936:
932:
928:
925:
924:
919:
915:
911:
899:
894:
890:
886:
883:
879:
872:
870:
867:
863:
859:
855:
850:
846:
839:
837:
831:
827:
824:
818:
816:
812:
806:
802:
799:
795:
788:
786:
780:
776:
773:
767:
765:
761:
755:
751:
748:
746:RefSeq (mRNA)
744:
737:
736:
731:
727:
724:
718:
717:
712:
708:
705:
703:
699:
692:
691:
686:
682:
679:
673:
669:
665:
662:
660:
656:
649:
648:
643:
639:
636:
630:
629:
624:
620:
617:
615:
611:
608:
605:
603:
600:
596:
593:
589:
585:
578:
574:
569:
563:
560:
558:
555:
553:
550:
548:
545:
543:
540:
538:
537:ion transport
535:
533:
530:
528:
525:
524:
522:
519:
518:
512:
509:
507:
504:
502:
499:
497:
494:
492:
489:
487:
484:
482:
479:
477:
474:
473:
471:
468:
467:
461:
458:
456:
453:
451:
448:
446:
443:
441:
438:
437:
435:
432:
431:
428:
427:Gene ontology
424:
420:
408:
403:
399:
394:
391:
389:
385:
377:
372:
361:
357:
353:
349:
345:
341:
337:
333:
329:
325:
324:
321:
317:
312:
309:
299:
295:
291:
287:
283:
279:
275:
271:
267:
263:
262:
259:
255:
250:
247:
246:
243:
241:
237:
235:
234:
230:
229:
226:
224:
220:
216:
212:
208:
200:
195:
191:
187:
182:
172:
168:
161:
154:
148:
141:
133:
129:
125:
120:
116:
111:
107:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
59:
54:
47:
42:
37:
33:
28:
19:
5816:
5815:
5801:
5766:
5740:Sergliflozin
5660:Atigliflozin
5656:
5615:
5548:
4644:transporter
4597:transporter
3683:transporter
3494:transporter
2877:- dependent
2446:
2445:
2419:
2415:
2386:
2382:
2354:
2350:
2313:
2309:
2274:
2270:
2239:
2235:
2204:
2200:
2163:
2159:
2137:(3): 752–4.
2134:
2130:
2103:
2099:
2050:
2046:
2001:
1997:
1970:
1966:
1922:
1918:
1908:
1881:
1877:
1867:
1847:
1840:
1831:
1822:
1789:
1785:
1779:
1738:
1734:
1682:
1678:
1632:
1628:
1622:
1579:
1575:
1565:
1535:(5): 510–8.
1532:
1528:
1522:
1497:
1493:
1480:
1453:
1447:
1422:
1418:
1378:
1374:
1364:
1323:
1264:
1260:
1234:
1225:
1216:
1207:
1166:
1163:Interactions
1133:
1131:
1119:
1104:
1098:
1086:
1075:
1061:
1051:brush-border
1026:
989:
953:
921:
913:
909:
908:
833:
815:NP_001243243
808:
782:
764:NM_001256314
757:
733:
714:
688:
671:
645:
626:
606:
601:
358:right kidney
238:
231:
61:External IDs
5840:Human genes
5802:Inhibitors:
5770:ISIS-388626
5657:Inhibitors:
5616:Inhibitors:
4504:zinc efflux
2381:families".
1500:: 197–212.
1039:prokaryotic
1015:SGLT family
354:Paneth cell
276:gallbladder
197:33,320,214
184:33,261,563
176:5|5 B1
39:Identifiers
5834:Categories
5595:modulators
5530:Cl-oxalate
5525:Cl-formate
5452:Na/glucose
4642:Acetyl-CoA
1202:, May 2017
1179:References
1035:eukaryotic
1023:symporters
1011:uniporters
968:C-terminal
350:left colon
242:(ortholog)
82:HomoloGene
5817:See also:
5730:Phlorizin
5725:Phloretin
5624:Phlorizin
5619:Phloretin
5549:see also
5421:Symporter
5409:Ion pumps
1699:1473-6543
1596:0012-1797
1397:1552-5260
1350:cite book
1342:949909675
1031:galactose
950:Structure
836:NP_062784
811:NP_000334
785:NM_019810
760:NM_000343
592:Orthologs
562:transport
90:GeneCards
5518:(Band 3)
5502:Na/(Ca-K
5072:SLC41–48
5025:SLC39A14
5020:SLC39A13
5015:SLC39A12
5010:SLC39A11
5005:SLC39A10
4937:SLC38A10
4578:SLC31–40
4554:SLC30A10
4368:SLC26A11
4363:SLC26A10
4295:SLC25A46
4290:SLC25A45
4285:SLC25A44
4280:SLC25A43
4275:SLC25A42
4270:SLC25A41
4265:SLC25A40
4260:SLC25A39
4255:SLC25A38
4250:SLC25A37
4245:SLC25A36
4240:SLC25A35
4235:SLC25A34
4230:SLC25A33
4225:SLC25A32
4220:SLC25A31
4215:SLC25A30
4210:SLC25A29
4205:SLC25A28
4200:SLC25A27
4195:SLC25A26
4190:SLC25A25
4185:SLC25A24
4180:SLC25A23
4175:SLC25A22
4170:SLC25A21
4165:SLC25A20
4160:SLC25A19
4155:SLC25A18
4150:SLC25A17
4145:SLC25A16
4140:SLC25A15
4135:SLC25A14
4130:SLC25A13
4125:SLC25A12
4120:SLC25A11
4115:SLC25A10
3961:SLC22A20
3956:SLC22A19
3951:SLC22A18
3946:SLC22A17
3941:SLC22A16
3936:SLC22A15
3931:SLC22A14
3926:SLC22A13
3921:SLC22A12
3916:SLC22A11
3911:SLC22A10
3750:SLC21–30
3681:thiamine
3563:SLC16A14
3558:SLC16A13
3553:SLC16A12
3548:SLC16A11
3543:SLC16A10
3271:SLC11–20
2875:chloride
2518:By group
2438:12082088
2403:12039040
2373:11406349
2338:22976632
2330:11131365
2301:10591208
2258:10036327
2131:Genomics
1989:12488461
1941:15090548
1900:21049241
1814:25248625
1806:12139397
1717:26125647
1649:24292921
1614:22124465
1576:Diabetes
1557:41985805
1549:12748858
1198:–
1169:interact
1140:See also
1114:diarrhea
986:Function
882:Wikidata
571:Sources:
481:membrane
326:duodenum
268:duodenum
5750:T-1095A
5634:T-1095A
5433:Na/K,Cl
5347:SLCO1–4
5307:SLC47A2
5302:SLC47A1
5279:SLC46A2
5274:SLC46A1
5251:SLC45A4
5246:SLC54A3
5241:SLC45A2
5236:SLC45A1
5213:SLC44A5
5208:SLC44A4
5203:SLC44A3
5198:SLC44A2
5193:SLC44A1
5170:SLC43A3
5165:SLC43A2
5160:SLC43A1
5104:SLC41A3
5099:SLC41A2
5094:SLC41A1
5048:SLC40A1
5000:SLC39A9
4995:SLC39A8
4990:SLC39A7
4985:SLC39A6
4980:SLC39A5
4975:SLC39A4
4970:SLC39A3
4965:SLC39A2
4960:SLC39A1
4932:SLC38A6
4927:SLC38A5
4922:SLC38A4
4917:SLC38A3
4912:SLC38A2
4907:SLC38A1
4884:SLC37A4
4879:SLC37A3
4874:SLC37A2
4869:SLC37A1
4843:SLC36A4
4838:SLC36A3
4833:SLC36A2
4828:SLC36A1
4805:SLC35E4
4800:SLC35E3
4795:SLC35E2
4790:SLC35E1
4781:SLC35D3
4776:SLC35D2
4771:SLC35D1
4762:SLC35C2
4757:SLC35C1
4748:SLC35B4
4743:SLC35B3
4738:SLC35B2
4733:SLC35B1
4724:SLC35A5
4719:SLC35A4
4714:SLC35A3
4709:SLC35A2
4704:SLC35A1
4681:SLC34A3
4676:SLC34A2
4671:SLC34A1
4648:SLC33A1
4624:SLC32A1
4601:SLC31A1
4549:SLC30A9
4544:SLC30A8
4539:SLC30A7
4534:SLC30A6
4529:SLC30A5
4524:SLC30A4
4519:SLC30A3
4514:SLC30A2
4509:SLC30A1
4486:SLC29A4
4481:SLC29A3
4476:SLC29A2
4471:SLC29A1
4448:SLC28A3
4443:SLC28A2
4438:SLC28A1
4416:SLC27A6
4411:SLC27A5
4406:SLC27A4
4401:SLC27A3
4396:SLC27A2
4391:SLC27A1
4358:SLC26A9
4353:SLC26A8
4348:SLC26A7
4343:SLC26A6
4338:SLC26A5
4333:SLC26A4
4328:SLC26A3
4323:SLC26A2
4318:SLC26A1
4110:SLC25A9
4105:SLC25A8
4100:SLC25A7
4095:SLC25A6
4090:SLC25A5
4085:SLC25A4
4080:SLC25A3
4075:SLC25A2
4070:SLC25A1
4047:SLC24A6
4042:SLC24A5
4037:SLC24A4
4032:SLC24A3
4027:SLC24A2
4022:SLC24A1
3999:SLC23A4
3994:SLC23A3
3989:SLC23A2
3984:SLC23A1
3906:SLC22A9
3901:SLC22A8
3896:SLC22A7
3891:SLC22A6
3886:SLC22A5
3881:SLC22A4
3876:SLC22A3
3871:SLC22A2
3866:SLC22A1
3842:SLCO6A1
3838:SLCO5A1
3829:SLCO4C1
3824:SLCO4A1
3815:SLCO3A1
3806:SLCO2B1
3801:SLCO2A1
3792:SLCO1C1
3787:SLCO1B4
3782:SLCO1B3
3777:SLCO1B1
3772:SLCO1A2
3726:SLC20A2
3721:SLC20A1
3697:SLC19A3
3692:SLC19A2
3687:SLC19A1
3659:SLC18A3
3654:SLC18A2
3649:SLC18A1
3626:SLC17A9
3621:SLC17A8
3616:SLC17A7
3611:SLC17A6
3606:SLC17A5
3601:SLC17A4
3596:SLC17A3
3591:SLC17A2
3586:SLC17A1
3538:SLC16A9
3533:SLC16A8
3528:SLC16A7
3523:SLC16A6
3518:SLC16A5
3513:SLC16A4
3508:SLC16A3
3503:SLC16A2
3498:SLC16A1
3474:SLC15A4
3469:SLC15A3
3464:SLC15A2
3459:SLC15A1
3436:SLC14A2
3431:SLC14A1
3408:SLC13A5
3403:SLC13A4
3398:SLC13A3
3393:SLC13A2
3388:SLC13A1
3365:SLC12A9
3360:SLC12A8
3355:SLC12A7
3350:SLC12A6
3345:SLC12A5
3340:SLC12A4
3335:SLC12A3
3330:SLC12A2
3325:SLC12A1
3298:SLC11A2
3293:SLC11A1
3227:SLC10A7
3222:SLC10A6
3217:SLC10A5
3212:SLC10A4
3207:SLC10A3
3202:SLC10A2
3197:SLC10A1
3174:SLC9A11
3169:SLC9A10
3068:SLC7A14
3063:SLC7A13
3058:SLC7A11
3053:SLC7A10
2979:SLC6A20
2974:SLC6A19
2969:SLC6A18
2964:SLC6A17
2959:SLC6A16
2954:SLC6A15
2949:SLC6A14
2944:SLC6A13
2939:SLC6A12
2934:SLC6A11
2929:SLC6A10
2533:SLC1–10
2279:Bibcode
2223:8567640
2188:2372635
2180:8563765
2151:8244393
2122:7759499
2087:2490366
2055:Bibcode
2034:4361495
2026:2008213
2006:Bibcode
1771:4319002
1763:2446136
1743:Bibcode
1708:5364028
1657:8525585
1605:3237647
1514:7823022
1439:9050236
1283:8195156
1200:Ensembl
1103:in the
1088:Xenopus
1072:Cloning
1067:History
999:glucose
943:nephron
941:of the
933:in the
918:protein
702:UniProt
659:Ensembl
598:Species
577:QuickGO
342:jejunum
217:pattern
46:Aliases
5787:&
5745:T-1095
5629:T-1095
4595:copper
3677:folate
3164:SLC9A9
3159:SLC9A8
3154:SLC9A7
3149:SLC9A6
3144:SLC9A5
3139:SLC9A4
3134:SLC9A3
3129:SLC9A2
3124:SLC9A1
3101:SLC8A3
3096:SLC8A2
3091:SLC8A1
3048:SLC7A9
3043:SLC7A8
3038:SLC7A7
3033:SLC7A6
3028:SLC7A5
3015:SLC7A4
3010:SLC7A3
3005:SLC7A2
3000:SLC7A1
2924:SLC6A9
2919:SLC6A8
2914:SLC6A7
2909:SLC6A6
2904:SLC6A5
2899:SLC6A4
2894:SLC6A3
2889:SLC6A2
2884:SLC6A1
2873:- and
2871:sodium
2798:SLC5A1
2725:SLC4A1
2697:SLC3A1
2608:SLC2A1
2555:SLC1A1
2436:
2401:
2371:
2336:
2328:
2299:
2271:Nature
2256:
2221:
2186:
2178:
2149:
2120:
2085:
2078:297707
2075:
2032:
2024:
1998:Nature
1987:
1939:
1898:
1855:
1812:
1804:
1769:
1761:
1735:Nature
1715:
1705:
1697:
1655:
1647:
1612:
1602:
1594:
1555:
1547:
1512:
1468:
1437:
1395:
1381:(S1).
1340:
1330:
1281:
1153:Family
1134:SLC5A1
1105:SLC5A1
1027:SLC5A1
1025:. The
923:SLC5A1
868:search
866:PubMed
735:Q8C3K6
716:P13866
614:Entrez
388:BioGPS
300:rectum
94:SLC5A1
78:107678
70:182380
53:SLC5A1
30:SLC5A1
18:SLC5A1
5790:SGLT2
5781:SGLT1
5645:SGLT2
5604:SGLT1
5497:Na/Ca
5447:Na/Cl
5318:(48):
5290:(47):
5262:(46):
5224:(45):
5181:(44):
5148:(43):
5115:(42):
5082:(41):
5036:(40):
4948:(39):
4895:(38):
4857:(37):
4816:(36):
4692:(35):
4659:(34):
4635:(33):
4612:(32):
4588:(31):
4497:(30):
4459:(29):
4427:(28):
4379:(27):
4306:(26):
4058:(25):
4010:(24):
3972:(23):
3854:(22):
3760:(21):
3708:(20):
3670:(19):
3637:(18):
3574:(17):
3485:(16):
3447:(15):
3419:(14):
3376:(13):
3312:(12):
3281:(11):
3185:(10):
2505:TC 2A
2334:S2CID
2184:S2CID
2030:S2CID
1963:(PDF)
1810:S2CID
1767:S2CID
1653:S2CID
1553:S2CID
1490:(PDF)
1171:with
1157:SGLT2
1033:into
916:is a
647:20537
607:Mouse
602:Human
573:Amigo
330:ileum
240:Mouse
233:Human
180:Start
115:Mouse
86:55456
5504:) -
5492:Na/H
5462:Cl/K
5457:Na/I
5438:Na/P
5382:O4A1
5377:O431
5372:O2B1
5367:O1B3
5362:O1B1
5357:O1A2
5137:RhCG
5132:RhBG
5127:RhAG
4846:36A2
3301:11A3
3249:10A7
3244:10A3
3239:10A2
3234:10A1
3112:(9):
3079:(8):
2990:(7):
2864:(6):
2786:(5):
2713:(4):
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