297:
1220:(CdLS), which is characterized by developmental abnormalities, cognitive impairment, and a range of physical abnormalities. A study showed a deletion of a portion of the long arm of chromosome 9 (9q31.1-q32) causes symptoms similar to those found in patients with CdLS. This deletion overlaps the gene encoding SMC2. Many mutations in a variety of different genes have been linked to CdLS, however around 30% of cases have not been linked to one of the known genes. More research is being done to discover other causes for this syndrome.
274:
171:
196:
555:
548:
303:
202:
1167:
2153:
1228:
Other studies have suggested that alterations in SMC2 protein expression may be involved in the development and progression of cancer. Overexpression of SMC2 has been found to lead to tumorigenesis and malignancy. Now, some research studies are exploring inhibition of SMC2 as a potential therapeutic
1154:
via their hinge domains. The heterodimer formed functions as a flexible and dynamic holocomplex core, which complexes with variant other non-SMC regulatory proteins to form condensin. In condensin I, SMC2 complexes with CAP-H, CAP-D2, and CAP-G. In condensin II, SMC2 complexes with CAP-H2, CAP-D3,
1871:
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K,
50:
1519:
Dávalos, Verónica; Súarez-López, Lucía; Castaño, Julio; Messent, Anthea; Abasolo, Ibane; Fernandez, Yolanda; Guerra-Moreno, Angel; Espín, Eloy; Armengol, Manel; Musulen, Eva; Ariza, Aurelio; Sayós, Joan; Arango, Diego; Schwartz, Simó (2012-12-21).
1755:
Montero, Sara; Seras-Franzoso, Joaquin; Andrade, Fernanda; Martinez-Trucharte, Francesc; Vilar-Hernández, Mireia; Quesada, Manuel; Xandri, Helena; Arango, Diego; Abasolo, Ibane; Rafael, Diana; Schwartz, Simo (2020-02-21).
2083:"A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation"
2665:
1138:
I and II, large protein complexes involved in chromosome condensation, overall organization. Several studies have demonstrated the necessity of SMC2 for cell division and proliferation.
1179:
SMC2 works in the condensin complex as transcriptional regulation by compacting replicated DNA prior to mitotic division via supercoiling of the DNA. SMC2 also functions in resolving
310:
209:
1522:"Human SMC2 Protein, a Core Subunit of Human Condensin Complex, Is a Novel Transcriptional Target of the WNT Signaling Pathway and a New Therapeutic Target *"
1400:
Eeftens, Jorine M.; Katan, Allard J.; Kschonsak, Marc; Hassler, Markus; de Wilde, Liza; Dief, Essam M.; Haering, Christian H.; Dekker, Cees (2016-03-01).
1962:"Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery"
1630:"Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery"
813:
794:
132:
2708:
1170:
Structure of a condensin protein holocomplex, displaying the SMC-2/SMC-4 heterodimer, and additional subunits. Kleisin is also depicted (blue).
2198:
1306:
1288:
1229:
target for the treatment of cancer as the inhibition of SMC2 expression or activity can lead to the induction of cell death in cancer cells.
2703:
47:
1053:
296:
2229:
2140:
provides an overview of all the structure information available in the PDB for Mouse
Structural maintenance of chromosomes protein 2
2134:
provides an overview of all the structure information available in the PDB for Human
Structural maintenance of chromosomes protein 2
1060:
273:
1960:
Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004).
1628:
Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004).
1383:
1275:
1254:
1271:
195:
170:
1250:
112:
1196:
309:
208:
2599:
1217:
2683:
2437:
2191:
302:
201:
2420:
2415:
2410:
2405:
2400:
2395:
1698:
Cao, Ruixue; Pu, Tian; Fang, Shaohai; Long, Fei; Xie, Jing; Xu, Yuejuan; Chen, Sun; Sun, Kun; Xu, Rang (2015).
858:
120:
1677:
1915:
Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics".
839:
2222:
2184:
1924:
1337:
184:
99:
1326:"Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics"
2207:
1032:
1003:
999:
995:
965:
940:
936:
932:
1011:
2360:
1948:
1859:
1737:
144:
1036:
1007:
969:
944:
1678:"Cornelia de Lange syndrome - About the Disease - Genetic and Rare Diseases Information Center"
2112:
2069:
2034:
1991:
1940:
1903:
1851:
1797:
1779:
1729:
1721:
1659:
1610:
1602:
1561:
1543:
1498:
1480:
1439:
1421:
1365:
1180:
92:
40:
2168:
1872:
Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007).
1700:"Patients Carrying 9q31.1-q32 Deletion Share Common Features with Cornelia de Lange Syndrome"
1521:
2251:
2215:
2102:
2094:
2059:
2024:
2016:
2005:"In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex"
1981:
1973:
1932:
1893:
1885:
1841:
1833:
1787:
1769:
1711:
1649:
1641:
1592:
1551:
1533:
1488:
1470:
1429:
1413:
1355:
1345:
1216:
Mutations in the SMC2 gene have been associated with a variety of human diseases, including
554:
389:
320:
264:
219:
2454:
2243:
1822:"Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma"
547:
364:
140:
1457:
Li, Xixi; Song, Guili; Zhao, Yasong; Ren, Jing; Li, Qing; Cui, Zongbin (September 2021).
1928:
1846:
1821:
1341:
2630:
2300:
2256:
1898:
1873:
1792:
1757:
1556:
1493:
1458:
1434:
1401:
2029:
2004:
1986:
1961:
1654:
1629:
1159:
which is found in cohesin, while CAP-D2, CAP-G, CAP-D3, and CAP-G2 contain structural
1155:
and CAP-G2. Subunits CAP-H and CAP-H2 are categorized as kleisin proteins, similar to
728:
723:
718:
713:
708:
703:
698:
693:
677:
672:
667:
662:
657:
652:
647:
642:
637:
632:
616:
611:
606:
601:
596:
2697:
2137:
2131:
2107:
2098:
2082:
1837:
1360:
1325:
1147:
583:
1863:
1741:
2484:
2264:
2239:
2164:
1952:
382:
161:
124:
1774:
1699:
1417:
148:
2636:
2499:
2489:
2372:
2270:
1874:"Large-scale mapping of human protein-protein interactions by mass spectrometry"
1820:
Ham MF, Takakuwa T, Rahadiani N, Tresnasari K, Nakajima H, Aozasa K (Jul 2007).
1475:
1324:
Schmiesing JA, Ball AR, Gregson HC, Alderton JM, Zhou S, Yokomori K (Oct 1998).
1311:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1293:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1160:
1131:
1330:
Proceedings of the
National Academy of Sciences of the United States of America
1166:
465:
2577:
2390:
2048:"Chromosome condensation by a human condensin complex in Xenopus egg extracts"
281:
178:
128:
1783:
1725:
1606:
1547:
1484:
1425:
1350:
2530:
2479:
2382:
2020:
1538:
1135:
758:
525:
403:
348:
335:
247:
234:
136:
2116:
2073:
2064:
2047:
2038:
1995:
1944:
1907:
1855:
1801:
1733:
1663:
1614:
1581:"Dynamic molecular linkers of the genome: the first decade of SMC proteins"
1565:
1502:
1443:
1758:"Intracellular Delivery of Anti-SMC2 Antibodies against Cancer Stem Cells"
1369:
1100:
1095:
2459:
1977:
1645:
1184:
1084:
907:
888:
884:
1936:
1597:
1580:
2508:
1889:
1120:
870:
825:
2003:
Przewloka MR, Pardington PE, Yannone SM, Chen DJ, Cary RB (Feb 2003).
1716:
69:
2560:
2550:
2540:
2535:
2447:
2430:
2365:
2355:
2350:
2345:
2340:
2335:
2330:
2325:
1200:
1068:
780:
103:, CAP-E, CAPE, SMC-2, SMC2L1, structural maintenance of chromosomes 2
2152:
2650:
2555:
2545:
2518:
2513:
2442:
2425:
2320:
2315:
2310:
2305:
2295:
2290:
2285:
2280:
2275:
1165:
1156:
743:
739:
2615:
2610:
2587:
2582:
2570:
2523:
2160:
1151:
1127:
563:
116:
2211:
1146:
As one of the 6 Eukaryotic SMC proteins, SMC2 forms a hetero
1384:"Entrez Gene: SMC2 structural maintenance of chromosomes 2"
2081:
Schmiesing JA, Gregson HC, Zhou S, Yokomori K (Sep 2000).
1459:"Functions of SMC2 in the Development of Zebrafish Liver"
372:
2172:
1402:"Condensin Smc2-Smc4 Dimers Are Flexible and Dynamic"
537:
2598:
2498:
2468:
2381:
2250:
1025:
988:
958:
925:
1267:
1265:
1263:
1246:
1244:
1242:
2666:transcription factors and intracellular receptors
319:
218:
1113:Structural maintenance of chromosomes protein 2
16:Protein-coding gene in the species Homo sapiens
1272:GRCm38: Ensembl release 89: ENSMUSG00000028312
2223:
2192:
8:
1579:Losada, Ana; Hirano, Tatsuya (2005-06-01).
1251:GRCh38: Ensembl release 89: ENSG00000136824
2472:
2230:
2216:
2208:
2199:
2185:
754:
579:
360:
259:
156:
58:
2106:
2063:
2046:Kimura K, Cuvier O, Hirano T (Feb 2001).
2028:
1985:
1897:
1845:
1791:
1773:
1715:
1653:
1596:
1555:
1537:
1492:
1474:
1433:
1359:
1349:
496:fetal liver hematopoietic progenitor cell
1238:
18:
1693:
1691:
324:
285:
280:
223:
182:
177:
7:
2149:
2147:
1704:Cellular Physiology and Biochemistry
1514:
1512:
1395:
1393:
2052:The Journal of Biological Chemistry
607:protein heterodimerization activity
512:migratory enteric neural crest cell
2171:. You can help Knowledge (XXG) by
1022:
985:
955:
922:
898:
875:
849:
830:
804:
785:
542:
460:
398:
377:
14:
1123:that in humans is encoded by the
2151:
2099:10.1128/MCB.20.18.6996-7006.2000
1838:10.1111/j.1349-7006.2007.00500.x
1134:family and is a core subunit of
553:
546:
308:
301:
295:
272:
207:
200:
194:
169:
1526:Journal of Biological Chemistry
1117:chromosome-associated protein E
729:mitotic chromosome condensation
699:meiotic chromosome condensation
2087:Molecular and Cellular Biology
709:meiotic chromosome segregation
564:More reference expression data
526:More reference expression data
1:
2709:Human chromosome 9 gene stubs
2009:Molecular Biology of the Cell
1775:10.3390/pharmaceutics12020185
293:
192:
1418:10.1016/j.celrep.2016.01.063
2704:Genes on human chromosome 9
1476:10.3390/biomedicines9091240
617:single-stranded DNA binding
2725:
2600:Transition nuclear protein
2146:
1218:Cornelia de Lange syndrome
1212:Cornelia de Lange Syndrome
2679:
2659:
2646:
2626:
2475:
2438:Perinucleolar compartment
1878:Molecular Systems Biology
1682:rarediseases.info.nih.gov
1307:"Mouse PubMed Reference:"
1289:"Human PubMed Reference:"
1099:
1094:
1090:
1083:
1067:
1054:Chr 9: 104.09 – 104.14 Mb
1048:
1029:
992:
981:
962:
929:
918:
905:
901:
882:
878:
869:
856:
852:
837:
833:
824:
811:
807:
792:
788:
779:
764:
757:
753:
737:
582:
578:
561:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1351:10.1073/pnas.95.22.12906
694:kinetochore organization
2021:10.1091/mbc.E01-11-0117
1585:Genes & Development
1539:10.1074/jbc.M112.428466
1195:SMC2 has been shown to
1130:. SMC2 is part of the
1115:(SMC-2), also known as
1061:Chr 4: 52.44 – 52.49 Mb
719:chromosome condensation
704:chromosome organization
2065:10.1074/jbc.C000873200
1966:Nucleic Acids Research
1634:Nucleic Acids Research
1171:
1207:Clinical significance
1169:
668:extracellular exosome
500:mandibular prominence
673:condensed chromosome
492:maxillary prominence
326:4 B2|4 28.31 cM
287:Chromosome 4 (mouse)
185:Chromosome 9 (human)
62:List of PDB id codes
35:Available structures
2391:Cajal (coiled) body
2252:Envelope (membrane)
1937:10.1038/nature03207
1929:2005Natur.433...77A
1598:10.1101/gad.1320505
1532:(52): 43472–43481.
1342:1998PNAS...9512906S
422:ganglionic eminence
2238:Structures of the
2159:This article on a
1978:10.1093/nar/gkh589
1890:10.1038/msb4100134
1646:10.1093/nar/gkh589
1172:
859:ENSMUSG00000028312
687:Biological process
658:nuclear chromosome
626:Cellular component
597:nucleotide binding
590:Molecular function
2691:
2690:
2675:
2674:
2180:
2179:
2093:(18): 6996–7006.
1717:10.1159/000369694
1591:(11): 1269–1287.
1181:Sister chromatids
1110:
1109:
1106:
1105:
1079:
1078:
1044:
1043:
1019:
1018:
977:
976:
952:
951:
914:
913:
895:
894:
865:
864:
846:
845:
820:
819:
801:
800:
749:
748:
653:condensin complex
574:
573:
570:
569:
532:
531:
519:
518:
457:
456:
450:bone marrow cells
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
2716:
2684:nucleus diseases
2633:(Nucleoskeleton)
2473:
2232:
2225:
2218:
2209:
2201:
2194:
2187:
2155:
2148:
2120:
2110:
2077:
2067:
2042:
2032:
1999:
1989:
1956:
1911:
1901:
1867:
1849:
1806:
1805:
1795:
1777:
1752:
1746:
1745:
1719:
1695:
1686:
1685:
1674:
1668:
1667:
1657:
1625:
1619:
1618:
1600:
1576:
1570:
1569:
1559:
1541:
1516:
1507:
1506:
1496:
1478:
1454:
1448:
1447:
1437:
1412:(8): 1813–1818.
1397:
1388:
1387:
1380:
1374:
1373:
1363:
1353:
1336:(22): 12906–11.
1321:
1315:
1314:
1303:
1297:
1296:
1285:
1279:
1269:
1258:
1248:
1092:
1091:
1063:
1056:
1039:
1023:
1014:
986:
982:RefSeq (protein)
972:
956:
947:
923:
899:
876:
850:
831:
805:
786:
755:
580:
566:
557:
550:
543:
528:
484:primitive streak
480:genital tubercle
468:
466:Top expressed in
461:
434:secondary oocyte
414:ventricular zone
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
149:SMC2 - orthologs
102:
95:
72:
59:
53:
32:
31:
19:
2724:
2723:
2719:
2718:
2717:
2715:
2714:
2713:
2694:
2693:
2692:
2687:
2671:
2655:
2642:
2622:
2594:
2494:
2464:
2377:
2255:
2246:
2244:nuclear protein
2236:
2206:
2205:
2144:
2128:
2123:
2080:
2045:
2002:
1959:
1923:(7021): 77–83.
1914:
1870:
1819:
1815:
1813:Further reading
1810:
1809:
1754:
1753:
1749:
1697:
1696:
1689:
1676:
1675:
1671:
1627:
1626:
1622:
1578:
1577:
1573:
1518:
1517:
1510:
1456:
1455:
1451:
1399:
1398:
1391:
1382:
1381:
1377:
1323:
1322:
1318:
1305:
1304:
1300:
1287:
1286:
1282:
1270:
1261:
1249:
1240:
1235:
1226:
1214:
1209:
1193:
1177:
1144:
1101:View/Edit Mouse
1096:View/Edit Human
1059:
1052:
1049:Location (UCSC)
1035:
1031:
1010:
1006:
1002:
998:
994:
968:
964:
943:
939:
935:
931:
887:
840:ENSG00000136824
733:
682:
621:
602:protein binding
562:
552:
551:
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
444:
442:trabecular bone
440:
436:
432:
430:Achilles tendon
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
2722:
2720:
2712:
2711:
2706:
2696:
2695:
2689:
2688:
2680:
2677:
2676:
2673:
2672:
2670:
2669:
2660:
2657:
2656:
2654:
2653:
2647:
2644:
2643:
2641:
2640:
2634:
2631:Nuclear matrix
2627:
2624:
2623:
2621:
2620:
2619:
2618:
2613:
2605:
2603:
2596:
2595:
2593:
2592:
2591:
2590:
2585:
2575:
2574:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2538:
2528:
2527:
2526:
2521:
2516:
2505:
2503:
2496:
2495:
2493:
2492:
2487:
2485:Dot (PML body)
2482:
2476:
2470:
2466:
2465:
2463:
2462:
2457:
2452:
2451:
2450:
2445:
2435:
2434:
2433:
2428:
2423:
2418:
2413:
2408:
2403:
2398:
2387:
2385:
2379:
2378:
2376:
2375:
2370:
2369:
2368:
2363:
2358:
2353:
2348:
2343:
2338:
2333:
2328:
2323:
2318:
2313:
2308:
2303:
2298:
2293:
2288:
2283:
2278:
2268:
2261:
2259:
2257:nuclear lamina
2248:
2247:
2237:
2235:
2234:
2227:
2220:
2212:
2204:
2203:
2196:
2189:
2181:
2178:
2177:
2156:
2142:
2141:
2135:
2127:
2126:External links
2124:
2122:
2121:
2078:
2058:(8): 5417–20.
2043:
2000:
1972:(9): 2716–29.
1957:
1912:
1868:
1826:Cancer Science
1816:
1814:
1811:
1808:
1807:
1747:
1710:(1): 270–280.
1687:
1669:
1640:(9): 2716–29.
1620:
1571:
1508:
1449:
1389:
1375:
1316:
1298:
1280:
1259:
1237:
1236:
1234:
1231:
1225:
1222:
1213:
1210:
1208:
1205:
1192:
1189:
1176:
1173:
1143:
1140:
1119:(CAP-E), is a
1108:
1107:
1104:
1103:
1098:
1088:
1087:
1081:
1080:
1077:
1076:
1074:
1072:
1065:
1064:
1057:
1050:
1046:
1045:
1042:
1041:
1027:
1026:
1020:
1017:
1016:
990:
989:
983:
979:
978:
975:
974:
960:
959:
953:
950:
949:
927:
926:
920:
916:
915:
912:
911:
903:
902:
896:
893:
892:
880:
879:
873:
867:
866:
863:
862:
854:
853:
847:
844:
843:
835:
834:
828:
822:
821:
818:
817:
809:
808:
802:
799:
798:
790:
789:
783:
777:
776:
771:
766:
762:
761:
751:
750:
747:
746:
735:
734:
732:
731:
726:
721:
716:
711:
706:
701:
696:
690:
688:
684:
683:
681:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
629:
627:
623:
622:
620:
619:
614:
609:
604:
599:
593:
591:
587:
586:
576:
575:
572:
571:
568:
567:
559:
558:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
488:abdominal wall
485:
481:
477:
476:tail of embryo
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2721:
2710:
2707:
2705:
2702:
2701:
2699:
2686:
2685:
2678:
2668:
2667:
2662:
2661:
2658:
2652:
2649:
2648:
2645:
2638:
2635:
2632:
2629:
2628:
2625:
2617:
2614:
2612:
2609:
2608:
2607:
2606:
2604:
2601:
2597:
2589:
2586:
2584:
2581:
2580:
2579:
2576:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2533:
2532:
2529:
2525:
2522:
2520:
2517:
2515:
2512:
2511:
2510:
2507:
2506:
2504:
2501:
2497:
2491:
2488:
2486:
2483:
2481:
2478:
2477:
2474:
2471:
2467:
2461:
2458:
2456:
2453:
2449:
2446:
2444:
2441:
2440:
2439:
2436:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2412:
2409:
2407:
2404:
2402:
2399:
2397:
2394:
2393:
2392:
2389:
2388:
2386:
2384:
2380:
2374:
2371:
2367:
2364:
2362:
2359:
2357:
2354:
2352:
2349:
2347:
2344:
2342:
2339:
2337:
2334:
2332:
2329:
2327:
2324:
2322:
2319:
2317:
2314:
2312:
2309:
2307:
2304:
2302:
2299:
2297:
2294:
2292:
2289:
2287:
2284:
2282:
2279:
2277:
2274:
2273:
2272:
2269:
2266:
2263:
2262:
2260:
2258:
2253:
2249:
2245:
2241:
2233:
2228:
2226:
2221:
2219:
2214:
2213:
2210:
2202:
2197:
2195:
2190:
2188:
2183:
2182:
2176:
2174:
2170:
2166:
2162:
2157:
2154:
2150:
2145:
2139:
2136:
2133:
2130:
2129:
2125:
2118:
2114:
2109:
2104:
2100:
2096:
2092:
2088:
2084:
2079:
2075:
2071:
2066:
2061:
2057:
2053:
2049:
2044:
2040:
2036:
2031:
2026:
2022:
2018:
2015:(2): 685–97.
2014:
2010:
2006:
2001:
1997:
1993:
1988:
1983:
1979:
1975:
1971:
1967:
1963:
1958:
1954:
1950:
1946:
1942:
1938:
1934:
1930:
1926:
1922:
1918:
1913:
1909:
1905:
1900:
1895:
1891:
1887:
1883:
1879:
1875:
1869:
1865:
1861:
1857:
1853:
1848:
1843:
1839:
1835:
1832:(7): 1041–7.
1831:
1827:
1823:
1818:
1817:
1812:
1803:
1799:
1794:
1789:
1785:
1781:
1776:
1771:
1767:
1763:
1762:Pharmaceutics
1759:
1751:
1748:
1743:
1739:
1735:
1731:
1727:
1723:
1718:
1713:
1709:
1705:
1701:
1694:
1692:
1688:
1684:. 2023-04-10.
1683:
1679:
1673:
1670:
1665:
1661:
1656:
1651:
1647:
1643:
1639:
1635:
1631:
1624:
1621:
1616:
1612:
1608:
1604:
1599:
1594:
1590:
1586:
1582:
1575:
1572:
1567:
1563:
1558:
1553:
1549:
1545:
1540:
1535:
1531:
1527:
1523:
1515:
1513:
1509:
1504:
1500:
1495:
1490:
1486:
1482:
1477:
1472:
1468:
1464:
1460:
1453:
1450:
1445:
1441:
1436:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1403:
1396:
1394:
1390:
1385:
1379:
1376:
1371:
1367:
1362:
1357:
1352:
1347:
1343:
1339:
1335:
1331:
1327:
1320:
1317:
1312:
1308:
1302:
1299:
1294:
1290:
1284:
1281:
1277:
1273:
1268:
1266:
1264:
1260:
1256:
1252:
1247:
1245:
1243:
1239:
1232:
1230:
1223:
1221:
1219:
1211:
1206:
1204:
1202:
1198:
1190:
1188:
1186:
1182:
1174:
1168:
1164:
1162:
1158:
1153:
1149:
1141:
1139:
1137:
1133:
1129:
1126:
1122:
1118:
1114:
1102:
1097:
1093:
1089:
1086:
1082:
1075:
1073:
1070:
1066:
1062:
1058:
1055:
1051:
1047:
1040:
1038:
1034:
1028:
1024:
1021:
1015:
1013:
1009:
1005:
1001:
997:
991:
987:
984:
980:
973:
971:
967:
961:
957:
954:
948:
946:
942:
938:
934:
928:
924:
921:
919:RefSeq (mRNA)
917:
910:
909:
904:
900:
897:
891:
890:
886:
881:
877:
874:
872:
868:
861:
860:
855:
851:
848:
842:
841:
836:
832:
829:
827:
823:
816:
815:
810:
806:
803:
797:
796:
791:
787:
784:
782:
778:
775:
772:
770:
767:
763:
760:
756:
752:
745:
741:
736:
730:
727:
725:
722:
720:
717:
715:
714:cell division
712:
710:
707:
705:
702:
700:
697:
695:
692:
691:
689:
686:
685:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
639:
636:
634:
631:
630:
628:
625:
624:
618:
615:
613:
610:
608:
605:
603:
600:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
2681:
2663:
2565:
2265:Pore complex
2240:cell nucleus
2173:expanding it
2165:chromosome 9
2158:
2143:
2090:
2086:
2055:
2051:
2012:
2008:
1969:
1965:
1920:
1916:
1881:
1877:
1829:
1825:
1765:
1761:
1750:
1707:
1703:
1681:
1672:
1637:
1633:
1623:
1588:
1584:
1574:
1529:
1525:
1466:
1463:Biomedicines
1462:
1452:
1409:
1406:Cell Reports
1405:
1378:
1333:
1329:
1319:
1310:
1301:
1292:
1283:
1227:
1215:
1194:
1191:Interactions
1178:
1161:HEAT repeats
1145:
1124:
1116:
1112:
1111:
1033:NP_001288341
1030:
1004:NP_001252531
1000:NP_001036016
996:NP_001036015
993:
966:NM_001301412
963:
941:NM_001265602
937:NM_001042551
933:NM_001042550
930:
906:
883:
857:
838:
812:
793:
773:
768:
504:vas deferens
388:
381:
246:104,141,419
233:104,094,260
108:External IDs
67:
2639:(Nucleosol)
2637:Nucleoplasm
2500:SMC protein
2490:Paraspeckle
2271:Nucleoporin
1469:(9): 1240.
1132:SMC protein
1012:NP_006435.2
648:nucleoplasm
612:ATP binding
446:bone marrow
347:52,488,260
334:52,439,243
86:Identifiers
2698:Categories
2578:DNA repair
1768:(2): 185.
1278:, May 2017
1257:, May 2017
1233:References
724:cell cycle
643:chromosome
392:(ortholog)
129:HomoloGene
2682:see also
2664:see also
2531:Condensin
2480:Chromatin
2383:Nucleolus
2163:on human
1884:(1): 89.
1784:1999-4923
1726:1015-8987
1607:0890-9369
1548:0021-9258
1485:2227-9059
1426:2211-1247
1183:prior to
1142:Structure
1136:condensin
1037:NP_032043
1008:NP_006435
970:NM_008017
945:NM_006444
759:Orthologs
663:nucleolus
633:cytoplasm
137:GeneCards
2117:10958694
2074:11136719
2039:12589063
1996:15148359
1945:15635413
1908:17353931
1864:25888221
1856:17488335
1847:11158810
1802:32098204
1742:41785465
1734:25591769
1664:15148359
1615:15937217
1566:23095742
1503:34572426
1444:26904946
1274:–
1253:–
1197:interact
1185:Anaphase
1175:Function
1085:Wikidata
738:Sources:
418:testicle
2509:Cohesin
2138:PDBe-KB
2132:PDBe-KB
1953:4344740
1925:Bibcode
1899:1847948
1793:7076674
1557:3527934
1494:8465584
1435:4785793
1370:9789013
1338:Bibcode
1276:Ensembl
1255:Ensembl
1121:protein
871:UniProt
826:Ensembl
765:Species
744:QuickGO
678:nucleus
638:cytosol
367:pattern
93:Aliases
2561:NCAPH2
2551:NCAPG2
2541:NCAPD3
2536:NCAPD2
2448:CUGBP1
2421:GEMIN7
2416:GEMIN6
2411:GEMIN5
2406:GEMIN4
2401:GEMIN2
2366:NUP214
2361:NUP210
2356:NUP205
2351:NUP188
2346:NUP160
2341:NUP155
2336:NUP153
2331:NUP133
2326:NUP107
2115:
2105:
2072:
2037:
2030:150001
2027:
1994:
1987:419596
1984:
1951:
1943:
1917:Nature
1906:
1896:
1862:
1854:
1844:
1800:
1790:
1782:
1740:
1732:
1724:
1662:
1655:419596
1652:
1613:
1605:
1564:
1554:
1546:
1501:
1491:
1483:
1442:
1432:
1424:
1368:
1358:
1224:Cancer
1201:DNMT3B
1071:search
1069:PubMed
908:Q8CG48
889:Q05D74
885:O95347
781:Entrez
538:BioGPS
508:dermis
225:9q31.1
125:106067
117:605576
2651:LITAF
2556:NCAPH
2546:NCAPG
2519:SMC1B
2514:SMC1A
2469:Other
2460:ATXN7
2443:PTBP1
2426:DDX20
2321:NUP98
2316:NUP93
2311:NUP88
2306:NUP85
2301:NUP62
2296:NUP54
2291:NUP50
2286:NUP43
2281:NUP37
2276:NUP35
2167:is a
2108:88774
1949:S2CID
1860:S2CID
1738:S2CID
1361:23650
1199:with
1150:with
1148:dimer
814:14211
795:10592
774:Mouse
769:Human
740:Amigo
438:sperm
426:gonad
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
2616:TNP2
2611:TNP1
2588:SMC6
2583:SMC5
2571:SMC4
2566:SMC2
2524:SMC3
2455:TCOF
2431:COIL
2373:AAAS
2169:stub
2161:gene
2113:PMID
2070:PMID
2035:PMID
1992:PMID
1941:PMID
1904:PMID
1852:PMID
1798:PMID
1780:ISSN
1730:PMID
1722:ISSN
1660:PMID
1611:PMID
1603:ISSN
1562:PMID
1544:ISSN
1499:PMID
1481:ISSN
1440:PMID
1422:ISSN
1366:PMID
1157:Scc1
1152:SMC4
1128:gene
1125:SMC2
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
141:SMC2
133:4705
113:OMIM
100:SMC2
70:4U4P
51:RCSB
48:PDBe
22:SMC2
2396:SMN
2103:PMC
2095:doi
2060:doi
2056:276
2025:PMC
2017:doi
1982:PMC
1974:doi
1933:doi
1921:433
1894:PMC
1886:doi
1842:PMC
1834:doi
1788:PMC
1770:doi
1712:doi
1650:PMC
1642:doi
1593:doi
1552:PMC
1534:doi
1530:287
1489:PMC
1471:doi
1430:PMC
1414:doi
1356:PMC
1346:doi
343:End
242:End
145:OMA
121:MGI
41:PDB
2700::
2242:/
2111:.
2101:.
2091:20
2089:.
2085:.
2068:.
2054:.
2050:.
2033:.
2023:.
2013:14
2011:.
2007:.
1990:.
1980:.
1970:32
1968:.
1964:.
1947:.
1939:.
1931:.
1919:.
1902:.
1892:.
1880:.
1876:.
1858:.
1850:.
1840:.
1830:98
1828:.
1824:.
1796:.
1786:.
1778:.
1766:12
1764:.
1760:.
1736:.
1728:.
1720:.
1708:35
1706:.
1702:.
1690:^
1680:.
1658:.
1648:.
1638:32
1636:.
1632:.
1609:.
1601:.
1589:19
1587:.
1583:.
1560:.
1550:.
1542:.
1528:.
1524:.
1511:^
1497:.
1487:.
1479:.
1465:.
1461:.
1438:.
1428:.
1420:.
1410:14
1408:.
1404:.
1392:^
1364:.
1354:.
1344:.
1334:95
1332:.
1328:.
1309:.
1291:.
1262:^
1241:^
1203:.
1187:.
1163:.
742:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
2602::
2502::
2267::
2254:/
2231:e
2224:t
2217:v
2200:e
2193:t
2186:v
2175:.
2119:.
2097::
2076:.
2062::
2041:.
2019::
1998:.
1976::
1955:.
1935::
1927::
1910:.
1888::
1882:3
1866:.
1836::
1804:.
1772::
1744:.
1714::
1666:.
1644::
1617:.
1595::
1568:.
1536::
1505:.
1473::
1467:9
1446:.
1416::
1386:.
1372:.
1348::
1340::
1313:.
1295:.
267:)
164:)
147::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
