314:
291:
188:
213:
565:
2665:
320:
219:
2695:
29:
2680:
1292:. This 14–3–3-like domain and a C-terminal helical hairpins domain with seven α-helices stacked perpendicular to the 14–3–3-like domain together form a monomeric tetratricopeptide region (TPR). Differences in the orientation and specific residues in the TPR between SMG6 and its homologs may account for why SMG6 does not form a
1373:
A multi-locus genetic risk score study based on a combination of 27 loci, including the SMG6 gene, identified individuals at increased risk for both incident and recurrent coronary artery disease events, as well as an enhanced clinical benefit from statin therapy. The study was based on a community
55:
1320:
reverse transcriptase to lengthen telomeres. Overexpression of SMG6 induces anaphase bridges due to chromosome-end fusions and, thus, affects telomere capping, which may directly induce an apoptotic response. SMG6 also functions as an
2313:
Hoff C, Seranski P, Mollenhauer J, Korn B, Detzel T, Reinhardt R, Ramser J, Poustka A (November 2000). "Physical and transcriptional mapping of the 17p13.3 region that is frequently deleted in human cancer".
1374:
cohort study (the Malmo Diet and Cancer study) and four additional randomized controlled trials of primary prevention cohorts (JUPITER and ASCOT) and secondary prevention cohorts (CARE and PROVE IT-TIMI 22).
1760:
Mega JL, Stitziel NO, Smith JG, Chasman DI, Caulfield MJ, Devlin JJ, Nordio F, Hyde CL, Cannon CP, Sacks FM, Poulter NR, Sever PS, Ridker PM, Braunwald E, Melander O, Kathiresan S, Sabatine MS (June 2015).
1357:(GWAS) on coronary artery disease. Accordingly, the association between recent smoking and the CpG sites within and near these coronary artery disease-related genes were investigated in 724
2239:
Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones".
327:
226:
2280:"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"
1365:
sites were found in SMG6 together with other genes, and several of these sites exhibited lower methylation in subjects currently smoking compared to never smoking.
878:
2585:
Takeshita D, Zenno S, Lee WC, Saigo K, Tanokura M (September 2007). "Crystal structure of the PIN domain of human telomerase-associated protein EST1A".
2345:"Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1"
1907:
Takeshita D, Zenno S, Lee WC, Saigo K, Tanokura M (September 2007). "Crystal structure of the PIN domain of human telomerase-associated protein EST1A".
859:
149:
1763:"Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: an analysis of primary and secondary prevention trials"
1450:
2723:
2644:
1432:
2664:
2694:
313:
52:
1113:
290:
1106:
1572:
2051:, Broccoli D, Dai Y, Hardy S, de Lange T (February 1999). "p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2".
1419:
1398:
2679:
1334:
2386:
Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S (November 2003).
212:
187:
1415:
2184:
Steenaard RV, Ligthart S, Stolk L, Peters MJ, van Meurs JB, Uitterlinden AG, Hofman A, Franco OH, Dehghan A (2015-01-01).
1354:
1337:(PTC)-containing mRNAs in human cells. SMG6 cleaves mRNA near the premature translocation-termination codons and requires
1394:
120:, C17orf31, EST1A, SMG-6, hSMG5/7a, nonsense mediated mRNA decay factor, SMG6 nonsense mediated mRNA decay factor, hEST1A
1204:
129:
2001:"Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5-SMG7 and SMG6"
326:
225:
2637:
319:
218:
1261:
923:
137:
1183:. It is ubiquitously expressed in many tissues and cell types. The C-terminus of the EST1A protein contains a
2278:
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998).
1326:
1216:
904:
2248:
2388:"Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7"
1473:"A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed"
1188:
1180:
201:
2544:"Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex"
1860:"Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex"
2630:
1245:
116:
2253:
1200:
1192:
1089:
1064:
1060:
1056:
1030:
1005:
1001:
997:
993:
2137:"A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD"
2610:
2487:
2458:"The human RNA surveillance factor UPF1 is required for S phase progression and genome stability"
1932:
1690:
1554:
1502:
161:
1068:
1009:
1659:
Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (April 2003).
1523:
Snow BE, Erdmann N, Cruickshank J, Goldman H, Gill RM, Robinson MO, Harrington L (April 2003).
2602:
2573:
2530:
2479:
2444:
2409:
2374:
2331:
2301:
2266:
2217:
2166:
2117:
2088:"SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan"
2068:
2030:
1981:
1952:"SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan"
1924:
1889:
1792:
1739:
1710:"SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan"
1682:
1641:
1546:
1494:
1293:
109:
45:
1811:"SMG6 SMG6, nonsense mediated mRNA decay factor [Homo sapiens (human)] - Gene - NCBI"
1268:
activity. The PIN domain forms an alpha/beta fold structure that similar to that found in 5'
2594:
2563:
2555:
2520:
2512:
2469:
2434:
2399:
2364:
2356:
2323:
2291:
2258:
2207:
2197:
2186:"Tobacco smoking is associated with methylation of genes related to coronary artery disease"
2156:
2148:
2107:
2099:
2060:
2020:
2012:
1971:
1963:
1916:
1879:
1871:
1782:
1774:
1729:
1721:
1672:
1631:
1623:
1536:
1484:
564:
406:
337:
281:
236:
1835:"SMG6 - Telomerase-binding protein EST1A - Homo sapiens (Human) - SMG6 gene & protein"
381:
157:
2568:
2543:
2525:
2500:
2421:
Fukuhara N, Ebert J, Unterholzner L, Lindner D, Izaurralde E, Conti E (February 2005).
2369:
2344:
2212:
2185:
2161:
2136:
2112:
2087:
2025:
2000:
1976:
1951:
1884:
1859:
1787:
1762:
1734:
1709:
1636:
1611:
1358:
1281:
2404:
2387:
1778:
1677:
1660:
1541:
1524:
1489:
1472:
793:
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
722:
717:
712:
707:
702:
697:
692:
687:
682:
666:
661:
656:
651:
646:
641:
636:
631:
626:
621:
616:
611:
606:
28:
2717:
2048:
1277:
593:
2614:
2491:
1936:
1506:
141:
1694:
1573:"Entrez Gene: SMG6 Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)"
1558:
1322:
1316:
surveillance pathways. SMG6 binds single-stranded telomere DNA and cooperates with
1265:
399:
178:
2064:
1586:
2501:"Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A"
2439:
2422:
1612:"Crystallization and preliminary X-ray analysis of the PIN domain of human EST1A"
165:
1471:
Reichenbach P, Höss M, Azzalin CM, Nabholz M, Bucher P, Lingner J (April 2003).
1455:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1437:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1362:
482:
2516:
2474:
2457:
2202:
1627:
1330:
1317:
1273:
1184:
298:
195:
145:
2559:
2296:
2279:
2086:
Huntzinger E, Kashima I, Fauser M, Saulière J, Izaurralde E (December 2008).
1950:
Huntzinger E, Kashima I, Fauser M, Saulière J, Izaurralde E (December 2008).
1875:
1708:
Huntzinger E, Kashima I, Fauser M, Saulière J, Izaurralde E (December 2008).
2262:
823:
542:
420:
365:
352:
264:
251:
153:
2606:
2577:
2534:
2483:
2448:
2423:"SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway"
2413:
2378:
2335:
2327:
2270:
2221:
2170:
2121:
2072:
2034:
1985:
1928:
1893:
1796:
1743:
1686:
1645:
1550:
1498:
1353:
In humans, selected genomic regions based on 150 SNPs were identified in a
2305:
1999:
Chakrabarti S, Bonneau F, Schüssler S, Eppinger E, Conti E (August 2014).
1810:
1153:
1148:
2152:
2135:
Nicholson P, Josi C, Kurosawa H, Yamashita A, Mühlemann O (August 2014).
2016:
1834:
1309:
1308:
SMG6 is broadly expressed in all human tissues. It has dual functions in
1269:
1257:
1241:
1196:
1137:
968:
949:
2360:
2103:
1967:
1725:
2598:
1920:
935:
890:
86:
82:
78:
74:
1264:. It contains a PIN domain, which is characteristic of proteins with
1169:
1121:
845:
1661:"Functional conservation of the telomerase protein Est1p in humans"
1525:"Functional conservation of the telomerase protein Est1p in humans"
759:
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
1236:
gene resides on chromosome 17 at the band 17p13.3 and contains 30
2542:
Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006).
1858:
Glavan F, Behm-Ansmant I, Izaurralde E, Conti E (November 2006).
1276:
that functions to cleave single-stranded RNA. SMG6 also shares a
808:
804:
1342:
1338:
1297:
1289:
1285:
1237:
1212:
1176:
573:
133:
2626:
2499:
Takeshita D, Zenno S, Lee WC, Saigo K, Tanokura M (July 2006).
1610:
Takeshita D, Zenno S, Lee WC, Saigo K, Tanokura M (July 2006).
2622:
1313:
1187:. This structure for this domain has been determined by
389:
1329:
pathway. The catalytic activity of SMG6 resides in its
2343:
Chiu SY, Serin G, Ohara O, Maquat LE (January 2003).
554:
2673:: Crystal structure of the PIN domain of human EST1A
2703:: Structure of human SMG6 E1282C PIN domain mutant.
1082:
1049:
1023:
986:
764:
RNA phosphodiester bond hydrolysis, endonucleolytic
1411:
1409:
1407:
1390:
1388:
1386:
1361:subjects from the Rotterdam Study. The identified
779:regulation of telomere maintenance via telomerase
336:
235:
1272:. Within the PIN domain is a canonical triad of
16:Protein-coding gene in the species Homo sapiens
1518:
1516:
1466:
1464:
1416:GRCm38: Ensembl release 89: ENSMUSG00000038290
2638:
8:
1395:GRCh38: Ensembl release 89: ENSG00000070366
1333:, which is required for the degradation of
739:nucleic acid phosphodiester bond hydrolysis
2645:
2631:
2623:
819:
589:
377:
276:
173:
63:
2567:
2524:
2473:
2438:
2403:
2368:
2295:
2252:
2211:
2201:
2160:
2111:
2024:
1975:
1883:
1786:
1733:
1676:
1635:
1540:
1488:
1335:premature translation termination codons
2688:: Structure of PIN domain of human SMG6
2660:
2456:Azzalin CM, Lingner J (February 2006).
1382:
749:negative regulation of telomere capping
1280:-binding domain resembling the one in
18:
1755:
1753:
1296:with SMG5 and SMG7 when recruited by
341:
302:
297:
240:
199:
194:
7:
789:telomere maintenance via telomerase
1587:"BioGPS - your Gene Portal System"
1215:associated with increased risk of
1079:
1046:
1020:
983:
959:
940:
914:
895:
869:
850:
794:RNA phosphodiester bond hydrolysis
774:regulation of telomere maintenance
559:
477:
415:
394:
14:
1172:that in humans is encoded by the
784:regulation of telomerase activity
708:telomerase catalytic core complex
662:ribonucleoprotein complex binding
2693:
2678:
2663:
2505:Acta Crystallographica Section F
1616:Acta Crystallographica Section F
1345:to reduce reporter mRNA levels.
1166:Telomerase-binding protein EST1A
563:
325:
318:
312:
289:
224:
217:
211:
186:
27:
754:regulation of dephosphorylation
574:More reference expression data
543:More reference expression data
467:right hemisphere of cerebellum
1:
2405:10.1016/S1097-2765(03)00443-X
2065:10.1126/science.283.5406.1321
1779:10.1016/S0140-6736(14)61730-X
1678:10.1016/s0960-9822(03)00210-0
1542:10.1016/S0960-9822(03)00210-0
1490:10.1016/S0960-9822(03)00173-8
1355:genome-wide association study
1284:with its other two homologs,
1211:gene also contains one of 27
718:telomerase holoenzyme complex
310:
209:
2724:Genes on human chromosome 17
2440:10.1016/j.molcel.2005.01.010
1205:nonsense-mediated mRNA decay
1185:PilT N-terminus (PIN) domain
1256:SMG6 is one of three human
769:regulation of RNA stability
431:stromal cell of endometrium
2740:
693:exon-exon junction complex
2658:
2517:10.1107/S1744309106020057
2475:10.1016/j.cub.2006.01.018
2203:10.1186/s13148-015-0088-y
1628:10.1107/S1744309106020057
1451:"Mouse PubMed Reference:"
1433:"Human PubMed Reference:"
1191:. SMG6 functions to bind
1152:
1147:
1143:
1136:
1120:
1101:
1086:
1053:
1042:
1027:
990:
979:
966:
962:
947:
943:
934:
921:
917:
902:
898:
889:
876:
872:
857:
853:
844:
829:
822:
818:
802:
652:endoribonuclease activity
592:
588:
571:
562:
553:
540:
489:
480:
427:
418:
388:
380:
376:
359:
346:
309:
288:
279:
275:
258:
245:
208:
185:
176:
172:
127:
124:
114:
107:
102:
71:
66:
49:
44:
39:
35:
26:
21:
2560:10.1038/sj.emboj.7601377
1876:10.1038/sj.emboj.7601377
1262:Saccharomyces cerevisiae
1114:Chr 11: 74.82 – 75.06 Mb
744:mRNA export from nucleus
529:Rostral migratory stream
1240:. This gene produces 3
1217:coronary artery disease
2328:10.1006/geno.2000.6353
2297:10.1093/dnares/5.5.277
2141:Nucleic Acids Research
2005:Nucleic Acids Research
647:telomerase RNA binding
622:DNA polymerase binding
2263:10.1093/dnares/9.3.99
1349:Clinical significance
1189:X-ray crystallography
1107:Chr 17: 2.06 – 2.3 Mb
667:ribonuclease activity
637:endonuclease activity
612:telomeric DNA binding
304:Chromosome 11 (mouse)
202:Chromosome 17 (human)
2190:Clinical Epigenetics
1815:www.ncbi.nlm.nih.gov
1246:alternative splicing
67:List of PDB id codes
40:Available structures
2361:10.1261/rna.2137903
2104:10.1261/rna.1386208
1968:10.1261/rna.1386208
1726:10.1261/rna.1386208
1260:for Est1p found in
1201:single-stranded RNA
1193:single-stranded DNA
463:ganglionic eminence
2599:10.1002/prot.21351
2153:10.1093/nar/gku645
2017:10.1093/nar/gku578
1921:10.1002/prot.21351
924:ENSMUSG00000038290
732:Biological process
676:Cellular component
642:hydrolase activity
600:Molecular function
517:supraoptic nucleus
459:anterior pituitary
2711:
2710:
1773:(9984): 2264–71.
1163:
1162:
1159:
1158:
1132:
1131:
1097:
1096:
1076:
1075:
1038:
1037:
1017:
1016:
975:
974:
956:
955:
930:
929:
911:
910:
885:
884:
866:
865:
814:
813:
632:nuclease activity
617:metal ion binding
584:
583:
580:
579:
549:
548:
536:
535:
474:
473:
372:
371:
271:
270:
98:
97:
94:
93:
50:Ortholog search:
2731:
2697:
2682:
2667:
2647:
2640:
2633:
2624:
2618:
2581:
2571:
2548:The EMBO Journal
2538:
2528:
2495:
2477:
2452:
2442:
2417:
2407:
2382:
2372:
2339:
2309:
2299:
2274:
2256:
2226:
2225:
2215:
2205:
2181:
2175:
2174:
2164:
2132:
2126:
2125:
2115:
2083:
2077:
2076:
2059:(5406): 1321–5.
2045:
2039:
2038:
2028:
1996:
1990:
1989:
1979:
1947:
1941:
1940:
1904:
1898:
1897:
1887:
1864:The EMBO Journal
1855:
1849:
1848:
1846:
1845:
1831:
1825:
1824:
1822:
1821:
1807:
1801:
1800:
1790:
1757:
1748:
1747:
1737:
1705:
1699:
1698:
1680:
1656:
1650:
1649:
1639:
1607:
1601:
1600:
1598:
1597:
1583:
1577:
1576:
1569:
1563:
1562:
1544:
1520:
1511:
1510:
1492:
1468:
1459:
1458:
1447:
1441:
1440:
1429:
1423:
1413:
1402:
1392:
1312:maintenance and
1199:maintenance and
1145:
1144:
1116:
1109:
1092:
1080:
1071:
1047:
1043:RefSeq (protein)
1033:
1021:
1012:
984:
960:
941:
915:
896:
870:
851:
820:
590:
576:
567:
560:
545:
525:ventricular zone
521:secondary oocyte
509:genital tubercle
485:
483:Top expressed in
478:
455:ventricular zone
423:
421:Top expressed in
416:
395:
378:
368:
355:
344:
329:
322:
316:
305:
293:
277:
267:
254:
243:
228:
221:
215:
204:
190:
174:
168:
166:SMG6 - orthologs
119:
112:
89:
64:
58:
37:
36:
31:
19:
2739:
2738:
2734:
2733:
2732:
2730:
2729:
2728:
2714:
2713:
2712:
2707:
2704:
2698:
2689:
2683:
2674:
2668:
2654:
2651:
2621:
2584:
2554:(21): 5117–25.
2541:
2511:(Pt 7): 656–8.
2498:
2462:Current Biology
2455:
2420:
2398:(5): 1187–200.
2385:
2342:
2312:
2277:
2238:
2234:
2232:Further reading
2229:
2183:
2182:
2178:
2147:(14): 9217–35.
2134:
2133:
2129:
2098:(12): 2609–17.
2085:
2084:
2080:
2047:
2046:
2042:
2011:(14): 9447–60.
1998:
1997:
1993:
1962:(12): 2609–17.
1949:
1948:
1944:
1906:
1905:
1901:
1870:(21): 5117–25.
1857:
1856:
1852:
1843:
1841:
1839:www.uniprot.org
1833:
1832:
1828:
1819:
1817:
1809:
1808:
1804:
1759:
1758:
1751:
1720:(12): 2609–17.
1707:
1706:
1702:
1665:Current Biology
1658:
1657:
1653:
1622:(Pt 7): 656–8.
1609:
1608:
1604:
1595:
1593:
1585:
1584:
1580:
1571:
1570:
1566:
1529:Current Biology
1522:
1521:
1514:
1477:Current Biology
1470:
1469:
1462:
1449:
1448:
1444:
1431:
1430:
1426:
1414:
1405:
1393:
1384:
1380:
1371:
1369:Clinical marker
1351:
1306:
1282:14–3–3 proteins
1274:acidic residues
1254:
1230:
1225:
1154:View/Edit Mouse
1149:View/Edit Human
1112:
1105:
1102:Location (UCSC)
1088:
1067:
1063:
1059:
1055:
1029:
1008:
1004:
1000:
996:
992:
905:ENSG00000070366
798:
727:
671:
627:protein binding
572:
541:
532:
527:
523:
519:
515:
511:
507:
503:
499:
497:ascending aorta
495:
481:
470:
465:
461:
457:
453:
449:
445:
441:
437:
433:
419:
363:
350:
342:
332:
331:
330:
323:
303:
280:Gene location (
262:
249:
241:
231:
230:
229:
222:
200:
177:Gene location (
128:
115:
108:
73:
51:
17:
12:
11:
5:
2737:
2735:
2727:
2726:
2716:
2715:
2709:
2708:
2706:
2705:
2699:
2692:
2690:
2684:
2677:
2675:
2669:
2662:
2659:
2656:
2655:
2652:
2650:
2649:
2642:
2635:
2627:
2620:
2619:
2582:
2539:
2496:
2453:
2427:Molecular Cell
2418:
2392:Molecular Cell
2383:
2340:
2310:
2275:
2254:10.1.1.500.923
2235:
2233:
2230:
2228:
2227:
2176:
2127:
2078:
2040:
1991:
1942:
1899:
1850:
1826:
1802:
1749:
1700:
1671:(8): 698–704.
1651:
1602:
1578:
1564:
1535:(8): 698–704.
1512:
1460:
1442:
1424:
1403:
1381:
1379:
1376:
1370:
1367:
1350:
1347:
1305:
1302:
1253:
1250:
1229:
1226:
1224:
1221:
1161:
1160:
1157:
1156:
1151:
1141:
1140:
1134:
1133:
1130:
1129:
1127:
1125:
1118:
1117:
1110:
1103:
1099:
1098:
1095:
1094:
1084:
1083:
1077:
1074:
1073:
1051:
1050:
1044:
1040:
1039:
1036:
1035:
1025:
1024:
1018:
1015:
1014:
988:
987:
981:
977:
976:
973:
972:
964:
963:
957:
954:
953:
945:
944:
938:
932:
931:
928:
927:
919:
918:
912:
909:
908:
900:
899:
893:
887:
886:
883:
882:
874:
873:
867:
864:
863:
855:
854:
848:
842:
841:
836:
831:
827:
826:
816:
815:
812:
811:
800:
799:
797:
796:
791:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
735:
733:
729:
728:
726:
725:
720:
715:
710:
705:
700:
695:
690:
685:
679:
677:
673:
672:
670:
669:
664:
659:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
603:
601:
597:
596:
586:
585:
582:
581:
578:
577:
569:
568:
557:
551:
550:
547:
546:
538:
537:
534:
533:
531:
530:
526:
522:
518:
514:
513:tail of embryo
510:
506:
502:
498:
494:
490:
487:
486:
475:
472:
471:
469:
468:
464:
460:
456:
452:
451:body of uterus
448:
444:
440:
436:
432:
428:
425:
424:
412:
411:
403:
392:
386:
385:
382:RNA expression
374:
373:
370:
369:
361:
357:
356:
348:
345:
340:
334:
333:
324:
317:
311:
307:
306:
301:
295:
294:
286:
285:
273:
272:
269:
268:
260:
256:
255:
247:
244:
239:
233:
232:
223:
216:
210:
206:
205:
198:
192:
191:
183:
182:
170:
169:
126:
122:
121:
113:
105:
104:
100:
99:
96:
95:
92:
91:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2736:
2725:
2722:
2721:
2719:
2702:
2696:
2691:
2687:
2681:
2676:
2672:
2666:
2661:
2657:
2648:
2643:
2641:
2636:
2634:
2629:
2628:
2625:
2616:
2612:
2608:
2604:
2600:
2596:
2592:
2588:
2583:
2579:
2575:
2570:
2565:
2561:
2557:
2553:
2549:
2545:
2540:
2536:
2532:
2527:
2522:
2518:
2514:
2510:
2506:
2502:
2497:
2493:
2489:
2485:
2481:
2476:
2471:
2467:
2463:
2459:
2454:
2450:
2446:
2441:
2436:
2433:(4): 537–47.
2432:
2428:
2424:
2419:
2415:
2411:
2406:
2401:
2397:
2393:
2389:
2384:
2380:
2376:
2371:
2366:
2362:
2358:
2354:
2350:
2346:
2341:
2337:
2333:
2329:
2325:
2321:
2317:
2311:
2307:
2303:
2298:
2293:
2290:(5): 277–86.
2289:
2285:
2281:
2276:
2272:
2268:
2264:
2260:
2255:
2250:
2247:(3): 99–106.
2246:
2242:
2237:
2236:
2231:
2223:
2219:
2214:
2209:
2204:
2199:
2195:
2191:
2187:
2180:
2177:
2172:
2168:
2163:
2158:
2154:
2150:
2146:
2142:
2138:
2131:
2128:
2123:
2119:
2114:
2109:
2105:
2101:
2097:
2093:
2089:
2082:
2079:
2074:
2070:
2066:
2062:
2058:
2054:
2050:
2044:
2041:
2036:
2032:
2027:
2022:
2018:
2014:
2010:
2006:
2002:
1995:
1992:
1987:
1983:
1978:
1973:
1969:
1965:
1961:
1957:
1953:
1946:
1943:
1938:
1934:
1930:
1926:
1922:
1918:
1914:
1910:
1903:
1900:
1895:
1891:
1886:
1881:
1877:
1873:
1869:
1865:
1861:
1854:
1851:
1840:
1836:
1830:
1827:
1816:
1812:
1806:
1803:
1798:
1794:
1789:
1784:
1780:
1776:
1772:
1768:
1764:
1756:
1754:
1750:
1745:
1741:
1736:
1731:
1727:
1723:
1719:
1715:
1711:
1704:
1701:
1696:
1692:
1688:
1684:
1679:
1674:
1670:
1666:
1662:
1655:
1652:
1647:
1643:
1638:
1633:
1629:
1625:
1621:
1617:
1613:
1606:
1603:
1592:
1588:
1582:
1579:
1574:
1568:
1565:
1560:
1556:
1552:
1548:
1543:
1538:
1534:
1530:
1526:
1519:
1517:
1513:
1508:
1504:
1500:
1496:
1491:
1486:
1483:(7): 568–74.
1482:
1478:
1474:
1467:
1465:
1461:
1456:
1452:
1446:
1443:
1438:
1434:
1428:
1425:
1421:
1417:
1412:
1410:
1408:
1404:
1400:
1396:
1391:
1389:
1387:
1383:
1377:
1375:
1368:
1366:
1364:
1360:
1356:
1348:
1346:
1344:
1340:
1336:
1332:
1328:
1324:
1319:
1315:
1311:
1303:
1301:
1299:
1295:
1291:
1287:
1283:
1279:
1278:phosphoserine
1275:
1271:
1267:
1263:
1259:
1251:
1249:
1247:
1243:
1239:
1235:
1227:
1222:
1220:
1218:
1214:
1210:
1206:
1202:
1198:
1194:
1190:
1186:
1182:
1181:chromosome 17
1178:
1175:
1171:
1167:
1155:
1150:
1146:
1142:
1139:
1135:
1128:
1126:
1123:
1119:
1115:
1111:
1108:
1104:
1100:
1093:
1091:
1085:
1081:
1078:
1072:
1070:
1066:
1062:
1058:
1052:
1048:
1045:
1041:
1034:
1032:
1026:
1022:
1019:
1013:
1011:
1007:
1003:
999:
995:
989:
985:
982:
980:RefSeq (mRNA)
978:
971:
970:
965:
961:
958:
952:
951:
946:
942:
939:
937:
933:
926:
925:
920:
916:
913:
907:
906:
901:
897:
894:
892:
888:
881:
880:
875:
871:
868:
862:
861:
856:
852:
849:
847:
843:
840:
837:
835:
832:
828:
825:
821:
817:
810:
806:
801:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
736:
734:
731:
730:
724:
721:
719:
716:
714:
711:
709:
706:
704:
701:
699:
696:
694:
691:
689:
686:
684:
681:
680:
678:
675:
674:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
633:
630:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
604:
602:
599:
598:
595:
594:Gene ontology
591:
587:
575:
570:
566:
561:
558:
556:
552:
544:
539:
528:
524:
520:
516:
512:
508:
504:
500:
496:
492:
491:
488:
484:
479:
476:
466:
462:
458:
454:
450:
446:
442:
438:
434:
430:
429:
426:
422:
417:
414:
413:
410:
408:
404:
402:
401:
397:
396:
393:
391:
387:
383:
379:
375:
367:
362:
358:
354:
349:
343:11|11 B5
339:
335:
328:
321:
315:
308:
300:
296:
292:
287:
283:
278:
274:
266:
261:
257:
253:
248:
238:
234:
227:
220:
214:
207:
203:
197:
193:
189:
184:
180:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
131:
123:
118:
111:
106:
101:
90:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2700:
2685:
2670:
2593:(4): 980–9.
2590:
2586:
2551:
2547:
2508:
2504:
2468:(4): 433–9.
2465:
2461:
2430:
2426:
2395:
2391:
2355:(1): 77–87.
2352:
2348:
2322:(1): 26–33.
2319:
2315:
2287:
2284:DNA Research
2283:
2244:
2241:DNA Research
2240:
2193:
2189:
2179:
2144:
2140:
2130:
2095:
2091:
2081:
2056:
2052:
2043:
2008:
2004:
1994:
1959:
1955:
1945:
1915:(4): 980–9.
1912:
1908:
1902:
1867:
1863:
1853:
1842:. Retrieved
1838:
1829:
1818:. Retrieved
1814:
1805:
1770:
1766:
1717:
1713:
1703:
1668:
1664:
1654:
1619:
1615:
1605:
1594:. Retrieved
1590:
1581:
1567:
1532:
1528:
1480:
1476:
1454:
1445:
1436:
1427:
1372:
1352:
1323:endonuclease
1307:
1266:ribonuclease
1255:
1233:
1231:
1208:
1173:
1165:
1164:
1090:NP_001002764
1087:
1065:NP_001269255
1061:NP_001243757
1057:NP_001243756
1054:
1031:NM_001002764
1028:
1006:NM_001282326
1002:NM_001256828
998:NM_001256827
994:NM_001170957
991:
967:
948:
922:
903:
877:
858:
838:
833:
505:spermatocyte
501:aortic valve
439:right testis
405:
398:
125:External IDs
72:
2653:PDB gallery
2049:Karlseder J
1363:methylation
1207:(NMD). The
657:RNA binding
607:DNA binding
447:left testis
443:right ovary
364:75,055,274
351:74,816,649
103:Identifiers
1844:2016-10-12
1820:2016-10-12
1596:2016-10-12
1591:biogps.org
1422:, May 2017
1401:, May 2017
1378:References
1331:PIN domain
1318:telomerase
698:chromosome
435:left ovary
409:(ortholog)
263:2,303,785
250:2,059,839
146:HomoloGene
2249:CiteSeerX
2196:(1): 54.
1359:Caucasian
1270:nucleases
1223:Structure
1069:NP_060045
1010:NM_017575
824:Orthologs
713:nucleolus
683:cytoplasm
493:spermatid
154:GeneCards
2718:Category
2615:43477604
2607:17557331
2587:Proteins
2578:17053788
2535:16820686
2492:17197870
2484:16488880
2449:15721257
2414:14636577
2379:12554878
2336:11087658
2316:Genomics
2271:12168954
2222:26015811
2171:25053839
2122:18974281
2073:10037601
2035:25013172
1986:18974281
1937:43477604
1929:17557331
1909:Proteins
1894:17053788
1797:25748612
1744:18974281
1687:12699629
1646:16820686
1551:12699629
1507:14423276
1499:12676087
1418:–
1397:–
1310:telomere
1304:Function
1258:homologs
1244:through
1242:isoforms
1197:telomere
1138:Wikidata
803:Sources:
703:telomere
2569:1630413
2526:2242961
2370:1370372
2306:9872452
2213:4443552
2162:4132754
2113:2590965
2053:Science
2026:4132714
1977:2590965
1885:1630413
1788:4608367
1735:2590965
1695:6685276
1637:2242961
1559:6685276
1420:Ensembl
1399:Ensembl
1325:in the
1294:complex
1252:Protein
936:UniProt
891:Ensembl
830:Species
809:QuickGO
723:nucleus
688:cytosol
384:pattern
242:17p13.3
142:2144117
110:Aliases
2613:
2605:
2576:
2566:
2533:
2523:
2490:
2482:
2447:
2412:
2377:
2367:
2334:
2304:
2269:
2251:
2220:
2210:
2169:
2159:
2120:
2110:
2071:
2033:
2023:
1984:
1974:
1935:
1927:
1892:
1882:
1795:
1785:
1767:Lancet
1742:
1732:
1693:
1685:
1644:
1634:
1557:
1549:
1505:
1497:
1170:enzyme
1168:is an
1124:search
1122:PubMed
969:P61406
950:Q86US8
879:103677
846:Entrez
555:BioGPS
134:610963
2611:S2CID
2488:S2CID
1933:S2CID
1691:S2CID
1555:S2CID
1503:S2CID
1238:exons
860:23293
839:Mouse
834:Human
805:Amigo
407:Mouse
400:Human
347:Start
282:Mouse
246:Start
179:Human
150:23024
2701:2hwx
2686:2hww
2671:2dok
2603:PMID
2574:PMID
2531:PMID
2480:PMID
2445:PMID
2410:PMID
2375:PMID
2332:PMID
2302:PMID
2267:PMID
2218:PMID
2167:PMID
2118:PMID
2069:PMID
2031:PMID
1982:PMID
1925:PMID
1890:PMID
1793:PMID
1740:PMID
1683:PMID
1642:PMID
1547:PMID
1495:PMID
1343:SMG1
1341:and
1339:UPF1
1298:UPF1
1290:SMG7
1288:and
1286:SMG5
1234:SMG6
1232:The
1228:Gene
1213:SNPs
1209:SMG6
1177:gene
1174:SMG6
390:Bgee
338:Band
299:Chr.
237:Band
196:Chr.
158:SMG6
130:OMIM
117:SMG6
87:4UM2
83:2HWX
79:2HWW
75:2DOK
56:RCSB
53:PDBe
22:SMG6
2595:doi
2564:PMC
2556:doi
2521:PMC
2513:doi
2470:doi
2435:doi
2400:doi
2365:PMC
2357:doi
2349:RNA
2324:doi
2292:doi
2259:doi
2208:PMC
2198:doi
2157:PMC
2149:doi
2108:PMC
2100:doi
2092:RNA
2061:doi
2057:283
2021:PMC
2013:doi
1972:PMC
1964:doi
1956:RNA
1917:doi
1880:PMC
1872:doi
1783:PMC
1775:doi
1771:385
1730:PMC
1722:doi
1714:RNA
1673:doi
1632:PMC
1624:doi
1537:doi
1485:doi
1327:NMD
1314:RNA
1203:in
1195:in
1179:on
360:End
259:End
162:OMA
138:MGI
46:PDB
2720::
2609:.
2601:.
2591:68
2589:.
2572:.
2562:.
2552:25
2550:.
2546:.
2529:.
2519:.
2509:62
2507:.
2503:.
2486:.
2478:.
2466:16
2464:.
2460:.
2443:.
2431:17
2429:.
2425:.
2408:.
2396:12
2394:.
2390:.
2373:.
2363:.
2351:.
2347:.
2330:.
2320:70
2318:.
2300:.
2286:.
2282:.
2265:.
2257:.
2243:.
2216:.
2206:.
2192:.
2188:.
2165:.
2155:.
2145:42
2143:.
2139:.
2116:.
2106:.
2096:14
2094:.
2090:.
2067:.
2055:.
2029:.
2019:.
2009:42
2007:.
2003:.
1980:.
1970:.
1960:14
1958:.
1954:.
1931:.
1923:.
1913:68
1911:.
1888:.
1878:.
1868:25
1866:.
1862:.
1837:.
1813:.
1791:.
1781:.
1769:.
1765:.
1752:^
1738:.
1728:.
1718:14
1716:.
1712:.
1689:.
1681:.
1669:13
1667:.
1663:.
1640:.
1630:.
1620:62
1618:.
1614:.
1589:.
1553:.
1545:.
1533:13
1531:.
1527:.
1515:^
1501:.
1493:.
1481:13
1479:.
1475:.
1463:^
1453:.
1435:.
1406:^
1385:^
1300:.
1248:.
1219:.
807:/
366:bp
353:bp
265:bp
252:bp
160:;
156::
152:;
148::
144:;
140::
136:;
132::
85:,
81:,
77:,
2646:e
2639:t
2632:v
2617:.
2597::
2580:.
2558::
2537:.
2515::
2494:.
2472::
2451:.
2437::
2416:.
2402::
2381:.
2359::
2353:9
2338:.
2326::
2308:.
2294::
2288:5
2273:.
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