139:
116:
1031:
causing the fragmentation of newly synthesized DNA. Also, 5-FU is directly incorporated into DNA. UNG and SMUG1 are most likely to tackle the genomic incorporation of uracil and 5-FU during replication. Current research suggests that of SMUG1 but not UNG corresponds to increase in sensitivity to 5-FU. It was suggested that SMUG1 can be potentially used as a predictive biomarkers of drug response and a mechanism for acquired resistance in certain types of tumors.
1006:. Uracil-DNA repair is essential to protect against mutations. Current evidence suggests that UNG and SMUG1 are the major enzymes responsible for the repair of the U:G mispairs. Uracil is also introduced into DNA as part of antibody gene diversification and its removal is critical to antibody diversification. UNG is known to be the major player in uracil removal but when depleted SMUG1 can provide a backup for UNG in the antibody diversification process.
342:
145:
1035:
one possible explanation is that cancer cells are under considerable oxidative stress compared to normal cells and unregulation of SMUG1 is essential for the repair of oxidative base damage and survival in cancer cells. In this case elevation of SMUG1 as opposed to depletion can be potentially used as a biomarker for survival.
1018:
to be potentially correlated with poor survival and linked to aggressive phenotype in breast cancer. Low SMUG1 expression is also associated with BRCA1, ATM, XRCC1, implying genomic instability in SMUG1 low tumors. Preclinical study where SMUG1 depletion has been shown to results in sensitivity to 5-FU chemotherapy.
1030:
5-Fluorouracil (5-FU) is a widely used in the treatment of a range of common cancers that causes DNA damage via two mechanisms. FU is thought to kill cells via the inhibition of thymidylate synthase and also deprive cells of TTP during DNA replication, which leads to the introduction of uracil in DNA
1017:
Low SMUG1 transcripts can impair DNA repair and thus increase mutation rate, enhance chromosomal instability and promote selection of more malignant clones with aggressive behavior. Loss of SMUG1 was shown to increase cancer predisposition in mice study. In addition low SMUG1 transcripts were shown
1034:
SMUG1 glycosylase is a key enzyme for repairing lesions generated during oxidative base damage. Investigation of SMUG1 expression in gastric cancers showed that overexpressed SMUG1 was correlated with patients’ poor survival. In gastric cancer inflammation is the driver for carcinogenesis. And thus
1021:
Low SMUG1 in gastric cancer, however, were showing the opposite result, promoting cancer survival and resistance to therapy. One possible explanation is that in gastric cancer inflammation is the driver for carcinogenesis and low concentrations of SMUG1 can be beneficial in repairing oxidative base
2595:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
2254:
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P,
2444:
Masaoka A, Matsubara M, Hasegawa R, Tanaka T, Kurisu S, Terato H, Ohyama Y, Karino N, Matsuda A, Ide H (May 2003). "Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions".
1947:
Masaoka A, Matsubara M, Hasegawa R, Tanaka T, Kurisu S, Terato H, Ohyama Y, Karino N, Matsuda A, Ide H (May 2003). "Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions".
1764:
Nilsen H, Rosewell I, Robins P, Skjelbred CF, Andersen S, Slupphaug G, Daly G, Krokan HE, Lindahl T, Barnes DE, Nilsen H, Rosewell I, Robins P, Skjelbred CF, Andersen S, Slupphaug G, Daly G, Krokan HE, Lindahl T, Barnes DE (June 2000).
1395:
1378:
1097:
1080:
2596:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
2255:
Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".
993:
that process uracil in DNA. SMUG1 function is to remove U or its derivatives from DNA. SMUG1 is able to excise uracil from both single- and doubledstranded DNA. Other DNA glycosylases linked to U removal are
2026:"Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice"
2380:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1009:
In addition to uracil, SMUG1 removes several pyrimidine oxidation products. and has a specific function to remove the thymine oxidation product 5-hydroxymethyl uracil from DNA.
1022:
damage (commonly seen in inflammatory environment). Thus SMUG1 might have complex roles in carcinogenesis and act differently based on the type of cancer and its properties.
152:
2411:"hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup"
2129:
An Q, Robins P, Lindahl T, Barnes DE (February 2007). "5-Fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity".
2078:"Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1) deficiency is linked to aggressive breast cancer and predicts response to adjuvant therapy"
1690:"hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup"
555:
536:
77:
1449:
2351:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1415:
1414:
1385:
1117:
1116:
1087:
2167:
Abdel-Fatah T, Arora A, Gorguc I, Abbotts R, Beebeejaun S, Storr S, Mohan V, Hawkes C, Soomro I, Lobo DN, Parsons SL, Madhusudan S (June 2013).
1413:
1115:
1384:
1086:
1556:
1538:
1429:
1131:
1403:
1105:
1908:"Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation"
138:
1404:
1106:
1855:
Di Noia J, Neuberger MS (September 2002). "Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase".
904:
1416:
1118:
1428:
1130:
115:
1418:
1120:
2211:"SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress"
1808:"B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil"
1671:
1427:
1424:
1129:
1126:
2076:
Abdel-Fatah TM, Albarakati N, Bowell L, Agarwal D, Moseley P, Hawkes C, Ball G, Chan S, Ellis IO, Madhusudan S (December 2013).
1525:
1401:
1393:
1103:
1095:
1421:
1409:
1123:
1111:
1521:
1391:
1390:
1093:
1092:
1419:
1417:
1389:
1121:
1119:
1091:
1405:
1107:
2168:
2409:
Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G (October 2002).
1688:
Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G (October 2002).
1488:
1399:
1101:
57:
1388:
1090:
1044:
151:
2760:"Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms"
1430:
1132:
1420:
1122:
144:
2308:"The human base excision repair enzyme SMUG1 directly interacts with DKC1 and contributes to RNA quality control"
1386:
1088:
2686:"Evaluation of NTHL1, NEIL1, NEIL2, MPG, TDG, UNG and SMUG1 genes in familial colorectal cancer predisposition"
1806:
Kavli B, Andersen S, Otterlei M, Liabakk NB, Imai K, Fischer A, Durandy A, Krokan HE, Slupphaug G (June 2005).
1426:
1425:
1423:
1412:
1411:
1410:
1394:
1387:
1381:
1128:
1127:
1125:
1114:
1113:
1112:
1096:
1089:
1083:
600:
65:
1408:
1407:
1406:
1402:
1400:
1398:
1397:
1396:
1392:
1382:
1110:
1109:
1108:
1104:
1102:
1100:
1099:
1098:
1094:
1084:
2554:"Human immunodeficiency virus type 1 Vpr induces the degradation of the UNG and SMUG uracil-DNA glycosylases"
1422:
1383:
1124:
1085:
1498:
999:
581:
1493:
995:
987:
2729:
Matsubara M, Tanaka T, Terato H, Ide H (2005). "Action mechanism of human SMUG1 uracil-DNA glycosylase".
1983:
Boorstein RJ, Cummings A, Marenstein DR, Chan MK, Ma Y, Neubert TA, Brown SM, Teebor GW (November 2001).
1729:
Krokan HE, Drabløs F, Slupphaug G (December 2002). "Uracil in DNA--occurrence, consequences and repair".
1627:
Boorstein RJ, Cummings A, Marenstein DR, Chan MK, Ma Y, Neubert TA, Brown SM, Teebor GW (November 2001).
1767:"Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication"
1580:"Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors"
2511:"Mutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase"
2811:
2605:
2264:
1864:
975:
44:
861:
857:
853:
849:
845:
841:
837:
833:
829:
825:
821:
817:
813:
809:
805:
801:
797:
793:
789:
785:
781:
777:
773:
769:
765:
761:
747:
743:
739:
735:
731:
680:
676:
672:
668:
664:
1985:"Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1"
1629:"Definitive identification of mammalian 5-hydroxymethyluracil DNA N-glycosylase activity as SMUG1"
2629:
2288:
2108:
1888:
1609:
1575:
89:
882:
757:
711:
690:
2643:"SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair"
2306:
Jobert L, Skjeldam HK, Dalhus B, Galashevskaya A, Vågbø CB, Bjørås M, Nilsen H (January 2013).
2789:
2746:
2717:
2672:
2621:
2583:
2540:
2497:
2462:
2432:
2397:
2368:
2329:
2280:
2236:
2191:
2146:
2100:
2055:
2006:
1965:
1929:
1880:
1837:
1788:
1746:
1711:
1650:
1601:
341:
37:
2077:
2779:
2771:
2738:
2707:
2697:
2662:
2654:
2613:
2573:
2565:
2530:
2522:
2487:
2454:
2422:
2389:
2360:
2319:
2272:
2226:
2218:
2183:
2138:
2092:
2045:
2037:
1996:
1957:
1919:
1872:
1827:
1819:
1778:
1738:
1701:
1640:
1591:
1377:
1079:
231:
162:
106:
85:
206:
2169:"Are DNA repair factors promising biomarkers for personalized therapy in gastric cancer?"
2609:
2268:
1868:
2784:
2759:
2712:
2685:
2667:
2642:
2578:
2569:
2553:
2476:"Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1"
2231:
2210:
2050:
2025:
1832:
1807:
1470:
1453:
1440:
2535:
2510:
2492:
2475:
2393:
1783:
1766:
1596:
1579:
470:
465:
460:
455:
439:
434:
429:
413:
408:
403:
398:
393:
388:
383:
2805:
2684:
Broderick P, Bagratuni T, Vijayakrishnan J, Lubbe S, Chandler I, Houlston RS (2006).
2364:
370:
2112:
1672:"Entrez Gene: SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1"
1613:
69:
2633:
2292:
1906:
Rada C, Di Noia JM, Neuberger MS, Rada C, Di Noia JM, Neuberger MS (October 2004).
1892:
224:
48:, FDG, HMUDG, UNG3, single-strand-selective monofunctional uracil-DNA glycosylase 1
2142:
2324:
2307:
2222:
1924:
1907:
93:
1561:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1543:
National Center for
Biotechnology Information, U.S. National Library of Medicine
990:
974:
from single- and double-stranded DNA in nuclear chromatin, thus contributing to
2509:
Matsubara M, Tanaka T, Terato H, Ohmae E, Izumi S, Katayanagi K, Ide H (2004).
264:
2758:
Pettersen HS, Sundheim O, Gilljam KM, Slupphaug G, Krokan HE, Kavli B (2007).
2096:
1064:
Click on genes, proteins and metabolites below to link to respective articles.
123:
73:
2658:
2742:
2702:
500:
190:
177:
81:
2793:
2750:
2721:
2676:
2625:
2587:
2544:
2501:
2466:
2436:
2427:
2410:
2333:
2284:
2240:
2195:
2150:
2104:
2059:
2010:
2001:
1984:
1969:
1933:
1884:
1841:
1792:
1750:
1742:
1715:
1706:
1689:
1654:
1645:
1628:
1605:
2401:
2372:
2187:
944:
939:
2775:
2526:
2209:
Nagaria P, Svilar D, Brown AR, Wang XH, Sobol RW, Wyatt MD (2013-03-01).
2041:
1823:
928:
645:
626:
2617:
2276:
1876:
612:
567:
2474:
Wibley JE, Waters TR, Haushalter K, Verdine GL, Pearl LH (June 2003).
2458:
1961:
971:
960:
912:
522:
1048:
485:
481:
1052:
1003:
967:
404:
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
350:
61:
2552:
Schröfelbauer B, Yu Q, Zeitlin SG, Landau NR (September 2005).
957:
Single-strand selective monofunctional uracil DNA glycosylase
1376:
1078:
2024:
Kemmerich K, Dingler FA, Rada C, Neuberger MS (July 2012).
1468:
The interactive pathway map can be edited at WikiPathways:
2217:. SI: DNA Repair and Genetic Instability. 743–744: 26–32.
414:
single-strand selective uracil DNA N-glycosylase activity
214:
331:
2162:
2160:
2071:
2069:
875:
730:
704:
663:
2641:Di Noia JM, Rada C, Neuberger MS (February 2006).
1517:
1515:
1513:
1574:Haushalter KA, Todd Stukenberg MW, Kirschner MW,
161:
1380:
1082:
16:Protein-coding gene in the species Homo sapiens
1522:GRCm38: Ensembl release 89: ENSMUSG00000036061
8:
1683:
1681:
2124:
2122:
727:
660:
496:
366:
202:
101:
2783:
2711:
2701:
2666:
2577:
2534:
2491:
2426:
2323:
2230:
2049:
2000:
1923:
1831:
1782:
1705:
1644:
1595:
1666:
1664:
461:cellular response to DNA damage stimulus
1509:
1461:
970:. SMUG1 is a glycosylase that removes
18:
166:
127:
122:
7:
2085:Breast Cancer Research and Treatment
1812:The Journal of Experimental Medicine
2415:The Journal of Biological Chemistry
1989:The Journal of Biological Chemistry
1694:The Journal of Biological Chemistry
1633:The Journal of Biological Chemistry
1439:|alt=Fluorouracil (5-FU) Activity
2570:10.1128/JVI.79.17.10978-10987.2005
2176:Antioxidants & Redox Signaling
872:
701:
636:
617:
591:
572:
546:
527:
336:
259:
240:
219:
14:
1471:"FluoropyrimidineActivity_WP1601"
963:that in humans is encoded by the
389:uracil DNA N-glycosylase activity
340:
150:
143:
137:
114:
2731:Nucleic Acids Symposium Series
1452:Fluorouracil (5-FU) Activity
351:More reference expression data
1:
2493:10.1016/S1097-2765(03)00235-1
2394:10.1016/S0378-1119(97)00411-3
2143:10.1158/0008-5472.CAN-06-2960
1784:10.1016/S1097-2765(00)80271-3
1597:10.1016/S0960-9822(99)80087-6
135:
2365:10.1016/0378-1119(94)90802-8
2325:10.1016/j.molcel.2012.11.010
2223:10.1016/j.mrfmmm.2012.12.001
1925:10.1016/j.molcel.2004.10.011
1489:DNA-deoxyinosine glycosylase
2828:
905:Chr 15: 103.06 – 103.08 Mb
394:DNA N-glycosylase activity
303:retinal pigment epithelium
2097:10.1007/s10549-013-2769-6
1557:"Mouse PubMed Reference:"
1539:"Human PubMed Reference:"
943:
938:
934:
927:
911:
894:
879:
754:
723:
708:
687:
656:
643:
639:
624:
620:
611:
598:
594:
579:
575:
566:
553:
549:
534:
530:
521:
506:
499:
495:
479:
369:
365:
348:
339:
330:
322:
271:
262:
247:
243:
213:
205:
201:
184:
171:
134:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
2659:10.1038/sj.emboj.7600939
1043:SMUG1 has been shown to
2703:10.1186/1471-2407-6-243
1499:Thymine-DNA glycosylase
1059:Interactive pathway map
2764:Nucleic Acids Research
2515:Nucleic Acids Research
2428:10.1074/jbc.M207107200
2030:Nucleic Acids Research
2002:10.1074/jbc.M106953200
1743:10.1038/sj.onc.1205996
1707:10.1074/jbc.M207107200
1646:10.1074/jbc.M106953200
1494:Uracil-DNA glycosylase
1433:
1135:
986:SMUG1 is an important
283:neural layer of retina
2743:10.1093/nass/49.1.295
2188:10.1089/ars.2012.4873
1432:
1134:
1026:Role in drug response
307:epithelium of urethra
129:Chromosome 15 (mouse)
1824:10.1084/jem.20050042
976:base excision repair
466:base-excision repair
2618:10.1038/nature04209
2610:2005Natur.437.1173R
2558:Journal of Virology
2277:10.1038/nature04209
2269:2005Natur.437.1173R
1877:10.1038/nature00981
1869:2002Natur.419...43D
2776:10.1093/nar/gkm372
2527:10.1093/nar/gkh859
2042:10.1093/nar/gks259
1434:
1136:
601:ENSMUSG00000036061
449:Biological process
423:Cellular component
409:hydrolase activity
377:Molecular function
2459:10.1021/bi0273213
2215:Mutation Research
1962:10.1021/bi0273213
1578:(February 1999).
954:
953:
950:
949:
923:
922:
890:
889:
869:
868:
719:
718:
698:
697:
652:
651:
633:
632:
607:
606:
588:
587:
562:
561:
543:
542:
491:
490:
361:
360:
357:
356:
326:
325:
318:
317:
256:
255:
197:
196:
94:SMUG1 - orthologs
2819:
2797:
2787:
2754:
2725:
2715:
2705:
2680:
2670:
2647:The EMBO Journal
2637:
2604:(7062): 1173–8.
2591:
2581:
2564:(17): 10978–87.
2548:
2538:
2521:(17): 5291–302.
2505:
2495:
2470:
2440:
2430:
2421:(42): 39926–36.
2405:
2376:
2338:
2337:
2327:
2303:
2297:
2296:
2263:(7062): 1173–8.
2251:
2245:
2244:
2234:
2206:
2200:
2199:
2173:
2164:
2155:
2154:
2126:
2117:
2116:
2082:
2073:
2064:
2063:
2053:
2021:
2015:
2014:
2004:
1980:
1974:
1973:
1944:
1938:
1937:
1927:
1903:
1897:
1896:
1852:
1846:
1845:
1835:
1803:
1797:
1796:
1786:
1761:
1755:
1754:
1726:
1720:
1719:
1709:
1700:(42): 39926–36.
1685:
1676:
1675:
1668:
1659:
1658:
1648:
1624:
1618:
1617:
1599:
1571:
1565:
1564:
1553:
1547:
1546:
1535:
1529:
1519:
1475:
1474:
1466:
1372:
1367:
1362:
1357:
1352:
1347:
1342:
1337:
1332:
1327:
1322:
1317:
1312:
1307:
1302:
1297:
1292:
1287:
1282:
1277:
1272:
1267:
1262:
1257:
1252:
1247:
1242:
1237:
1232:
1227:
1222:
1217:
1212:
1207:
1202:
1197:
1192:
1187:
1182:
1177:
1172:
1167:
1162:
1157:
1152:
1147:
1142:
936:
935:
907:
900:
885:
873:
864:
728:
724:RefSeq (protein)
714:
702:
693:
661:
637:
618:
592:
573:
547:
528:
497:
456:depyrimidination
367:
353:
344:
337:
275:secondary oocyte
267:
265:Top expressed in
260:
241:
220:
203:
193:
180:
169:
154:
147:
141:
130:
118:
102:
96:
47:
40:
19:
2827:
2826:
2822:
2821:
2820:
2818:
2817:
2816:
2802:
2801:
2800:
2770:(12): 3879–92.
2757:
2728:
2683:
2640:
2594:
2551:
2508:
2473:
2453:(17): 5003–12.
2443:
2408:
2388:(1–2): 149–56.
2379:
2350:
2346:
2344:Further reading
2341:
2305:
2304:
2300:
2253:
2252:
2248:
2208:
2207:
2203:
2171:
2166:
2165:
2158:
2131:Cancer Research
2128:
2127:
2120:
2080:
2075:
2074:
2067:
2036:(13): 6016–25.
2023:
2022:
2018:
1995:(45): 41991–7.
1982:
1981:
1977:
1956:(17): 5003–12.
1946:
1945:
1941:
1905:
1904:
1900:
1854:
1853:
1849:
1818:(12): 2011–21.
1805:
1804:
1800:
1763:
1762:
1758:
1737:(58): 8935–48.
1728:
1727:
1723:
1687:
1686:
1679:
1670:
1669:
1662:
1639:(45): 41991–7.
1626:
1625:
1621:
1584:Current Biology
1573:
1572:
1568:
1555:
1554:
1550:
1537:
1536:
1532:
1520:
1511:
1507:
1485:
1480:
1479:
1478:
1469:
1467:
1463:
1458:
1457:
1456:
1451:
1446:
1445:
1444:
1438:
1437:
1436:
1435:
1431:
1374:
1373:
1370:
1368:
1365:
1363:
1360:
1358:
1355:
1353:
1350:
1348:
1345:
1343:
1340:
1338:
1335:
1333:
1330:
1328:
1325:
1323:
1320:
1318:
1315:
1313:
1310:
1308:
1305:
1303:
1300:
1298:
1295:
1293:
1290:
1288:
1285:
1283:
1280:
1278:
1275:
1273:
1270:
1268:
1265:
1263:
1260:
1258:
1255:
1253:
1250:
1248:
1245:
1243:
1240:
1238:
1235:
1233:
1230:
1228:
1225:
1223:
1220:
1218:
1215:
1213:
1210:
1208:
1205:
1203:
1200:
1198:
1195:
1193:
1190:
1188:
1185:
1183:
1180:
1178:
1175:
1173:
1170:
1168:
1165:
1163:
1160:
1158:
1155:
1153:
1150:
1148:
1145:
1143:
1140:
1137:
1133:
1061:
1041:
1028:
1015:
984:
945:View/Edit Mouse
940:View/Edit Human
903:
898:
895:Location (UCSC)
881:
860:
856:
852:
848:
844:
840:
836:
832:
828:
824:
820:
816:
812:
808:
804:
800:
796:
792:
788:
784:
780:
776:
772:
768:
764:
760:
756:
750:
746:
742:
738:
734:
710:
689:
683:
679:
675:
671:
667:
582:ENSG00000123415
475:
444:
418:
399:protein binding
349:
314:
309:
305:
301:
297:
293:
289:
285:
281:
277:
263:
252:
188:
175:
167:
157:
156:
155:
148:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
2825:
2823:
2815:
2814:
2804:
2803:
2799:
2798:
2755:
2726:
2681:
2638:
2592:
2549:
2506:
2486:(6): 1647–59.
2480:Molecular Cell
2471:
2441:
2406:
2377:
2359:(1–2): 171–4.
2347:
2345:
2342:
2340:
2339:
2312:Molecular Cell
2298:
2246:
2201:
2182:(18): 2392–8.
2156:
2118:
2065:
2016:
1975:
1939:
1912:Molecular Cell
1898:
1863:(6902): 43–8.
1847:
1798:
1777:(6): 1059–65.
1771:Molecular Cell
1756:
1721:
1677:
1660:
1619:
1566:
1548:
1530:
1508:
1506:
1503:
1502:
1501:
1496:
1491:
1484:
1481:
1477:
1476:
1460:
1459:
1448:
1447:
1375:
1369:
1364:
1359:
1354:
1349:
1344:
1339:
1334:
1329:
1324:
1319:
1314:
1309:
1304:
1299:
1294:
1289:
1284:
1279:
1274:
1269:
1264:
1259:
1254:
1249:
1244:
1239:
1234:
1229:
1224:
1219:
1214:
1209:
1204:
1199:
1194:
1189:
1184:
1179:
1174:
1169:
1164:
1159:
1154:
1149:
1144:
1139:
1138:
1077:
1076:
1075:
1074:
1072:
1071:
1070:
1069:
1068:
1067:
1060:
1057:
1040:
1037:
1027:
1024:
1014:
1013:Role in cancer
1011:
983:
980:
952:
951:
948:
947:
942:
932:
931:
925:
924:
921:
920:
918:
916:
909:
908:
901:
896:
892:
891:
888:
887:
877:
876:
870:
867:
866:
752:
751:
725:
721:
720:
717:
716:
706:
705:
699:
696:
695:
685:
684:
658:
654:
653:
650:
649:
641:
640:
634:
631:
630:
622:
621:
615:
609:
608:
605:
604:
596:
595:
589:
586:
585:
577:
576:
570:
564:
563:
560:
559:
551:
550:
544:
541:
540:
532:
531:
525:
519:
518:
513:
508:
504:
503:
493:
492:
489:
488:
477:
476:
474:
473:
468:
463:
458:
452:
450:
446:
445:
443:
442:
437:
432:
426:
424:
420:
419:
417:
416:
411:
406:
401:
396:
391:
386:
380:
378:
374:
373:
363:
362:
359:
358:
355:
354:
346:
345:
334:
328:
327:
324:
323:
320:
319:
316:
315:
313:
312:
308:
304:
300:
296:
292:
288:
287:tail of embryo
284:
280:
279:primary oocyte
276:
272:
269:
268:
257:
254:
253:
251:
248:
245:
244:
237:
236:
228:
217:
211:
210:
207:RNA expression
199:
198:
195:
194:
186:
182:
181:
173:
170:
165:
159:
158:
149:
142:
136:
132:
131:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2824:
2813:
2810:
2809:
2807:
2795:
2791:
2786:
2781:
2777:
2773:
2769:
2765:
2761:
2756:
2752:
2748:
2744:
2740:
2737:(49): 295–6.
2736:
2732:
2727:
2723:
2719:
2714:
2709:
2704:
2699:
2695:
2691:
2687:
2682:
2678:
2674:
2669:
2664:
2660:
2656:
2653:(3): 585–95.
2652:
2648:
2644:
2639:
2635:
2631:
2627:
2623:
2619:
2615:
2611:
2607:
2603:
2599:
2593:
2589:
2585:
2580:
2575:
2571:
2567:
2563:
2559:
2555:
2550:
2546:
2542:
2537:
2532:
2528:
2524:
2520:
2516:
2512:
2507:
2503:
2499:
2494:
2489:
2485:
2481:
2477:
2472:
2468:
2464:
2460:
2456:
2452:
2448:
2442:
2438:
2434:
2429:
2424:
2420:
2416:
2412:
2407:
2403:
2399:
2395:
2391:
2387:
2383:
2378:
2374:
2370:
2366:
2362:
2358:
2354:
2349:
2348:
2343:
2335:
2331:
2326:
2321:
2318:(2): 339–45.
2317:
2313:
2309:
2302:
2299:
2294:
2290:
2286:
2282:
2278:
2274:
2270:
2266:
2262:
2258:
2250:
2247:
2242:
2238:
2233:
2228:
2224:
2220:
2216:
2212:
2205:
2202:
2197:
2193:
2189:
2185:
2181:
2177:
2170:
2163:
2161:
2157:
2152:
2148:
2144:
2140:
2136:
2132:
2125:
2123:
2119:
2114:
2110:
2106:
2102:
2098:
2094:
2091:(3): 515–27.
2090:
2086:
2079:
2072:
2070:
2066:
2061:
2057:
2052:
2047:
2043:
2039:
2035:
2031:
2027:
2020:
2017:
2012:
2008:
2003:
1998:
1994:
1990:
1986:
1979:
1976:
1971:
1967:
1963:
1959:
1955:
1951:
1943:
1940:
1935:
1931:
1926:
1921:
1918:(2): 163–71.
1917:
1913:
1909:
1902:
1899:
1894:
1890:
1886:
1882:
1878:
1874:
1870:
1866:
1862:
1858:
1851:
1848:
1843:
1839:
1834:
1829:
1825:
1821:
1817:
1813:
1809:
1802:
1799:
1794:
1790:
1785:
1780:
1776:
1772:
1768:
1760:
1757:
1752:
1748:
1744:
1740:
1736:
1732:
1725:
1722:
1717:
1713:
1708:
1703:
1699:
1695:
1691:
1684:
1682:
1678:
1673:
1667:
1665:
1661:
1656:
1652:
1647:
1642:
1638:
1634:
1630:
1623:
1620:
1615:
1611:
1607:
1603:
1598:
1593:
1590:(4): 174–85.
1589:
1585:
1581:
1577:
1570:
1567:
1562:
1558:
1552:
1549:
1544:
1540:
1534:
1531:
1527:
1523:
1518:
1516:
1514:
1510:
1504:
1500:
1497:
1495:
1492:
1490:
1487:
1486:
1482:
1472:
1465:
1462:
1455:
1450:
1442:
1379:
1081:
1066:
1065:
1058:
1056:
1054:
1050:
1046:
1038:
1036:
1032:
1025:
1023:
1019:
1012:
1010:
1007:
1005:
1001:
997:
992:
989:
981:
979:
977:
973:
969:
966:
962:
958:
946:
941:
937:
933:
930:
926:
919:
917:
914:
910:
906:
902:
897:
893:
886:
884:
878:
874:
871:
865:
863:
859:
855:
851:
847:
843:
839:
835:
831:
827:
823:
819:
815:
811:
807:
803:
799:
795:
791:
787:
783:
779:
775:
771:
767:
763:
759:
753:
749:
745:
741:
737:
733:
729:
726:
722:
715:
713:
707:
703:
700:
694:
692:
686:
682:
678:
674:
670:
666:
662:
659:
657:RefSeq (mRNA)
655:
648:
647:
642:
638:
635:
629:
628:
623:
619:
616:
614:
610:
603:
602:
597:
593:
590:
584:
583:
578:
574:
571:
569:
565:
558:
557:
552:
548:
545:
539:
538:
533:
529:
526:
524:
520:
517:
514:
512:
509:
505:
502:
498:
494:
487:
483:
478:
472:
469:
467:
464:
462:
459:
457:
454:
453:
451:
448:
447:
441:
438:
436:
433:
431:
428:
427:
425:
422:
421:
415:
412:
410:
407:
405:
402:
400:
397:
395:
392:
390:
387:
385:
382:
381:
379:
376:
375:
372:
371:Gene ontology
368:
364:
352:
347:
343:
338:
335:
333:
329:
321:
311:otolith organ
310:
306:
302:
299:hair follicle
298:
294:
290:
286:
282:
278:
274:
273:
270:
266:
261:
258:
249:
246:
242:
239:
238:
235:
233:
229:
227:
226:
222:
221:
218:
216:
212:
208:
204:
200:
192:
187:
183:
179:
174:
168:15|15 F3
164:
160:
153:
146:
140:
133:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2767:
2763:
2734:
2730:
2693:
2689:
2650:
2646:
2601:
2597:
2561:
2557:
2518:
2514:
2483:
2479:
2450:
2447:Biochemistry
2446:
2418:
2414:
2385:
2381:
2356:
2352:
2315:
2311:
2301:
2260:
2256:
2249:
2214:
2204:
2179:
2175:
2137:(3): 940–5.
2134:
2130:
2088:
2084:
2033:
2029:
2019:
1992:
1988:
1978:
1953:
1950:Biochemistry
1949:
1942:
1915:
1911:
1901:
1860:
1856:
1850:
1815:
1811:
1801:
1774:
1770:
1759:
1734:
1730:
1724:
1697:
1693:
1636:
1632:
1622:
1587:
1583:
1569:
1560:
1551:
1542:
1533:
1464:
1063:
1062:
1042:
1039:Interactions
1033:
1029:
1020:
1016:
1008:
991:glycosylases
985:
964:
956:
955:
880:
862:NP_001338191
858:NP_001338190
854:NP_001338189
850:NP_001338188
846:NP_001338187
842:NP_001338186
838:NP_001338185
834:NP_001338184
830:NP_001338183
826:NP_001338182
822:NP_001338181
818:NP_001338180
814:NP_001338179
810:NP_001338178
806:NP_001338177
802:NP_001338176
798:NP_001338175
794:NP_001338174
790:NP_001338173
786:NP_001338172
782:NP_001338171
778:NP_001338170
774:NP_001338169
770:NP_001338168
766:NP_001338167
762:NP_001338166
755:
748:NP_001230720
744:NP_001230719
740:NP_001230718
736:NP_001230717
732:NP_001230716
709:
688:
681:NM_001243791
677:NM_001243790
673:NM_001243789
669:NM_001243788
665:NM_001243787
644:
625:
599:
580:
554:
535:
515:
510:
295:otic vesicle
230:
223:
189:103,075,519
176:103,061,717
53:External IDs
2812:Human genes
440:nucleoplasm
384:DNA binding
31:Identifiers
2690:BMC Cancer
1576:Verdine GL
1528:, May 2017
1505:References
988:uracil-DNA
471:DNA repair
234:(ortholog)
74:HomoloGene
1051:and with
883:NP_082161
758:NP_055126
712:NM_027885
691:NM_014311
501:Orthologs
430:nucleolus
82:GeneCards
2806:Category
2794:17537817
2751:17150750
2722:17029639
2677:16407970
2626:16189514
2588:16103149
2545:15466595
2502:12820976
2467:12718543
2437:12161446
2334:23246433
2285:16189514
2241:23253900
2196:22894650
2151:17283124
2113:36397609
2105:24253812
2060:22447450
2011:11526119
1970:12718543
1934:15494304
1885:12214226
1842:15967827
1793:10912000
1751:12483510
1731:Oncogene
1716:12161446
1655:11526119
1614:13930983
1606:10074426
1524:–
1483:See also
1045:interact
982:Function
929:Wikidata
480:Sources:
2785:1919486
2713:1624846
2696:: 243.
2668:1383525
2634:4427026
2606:Bibcode
2579:1193627
2402:9373149
2373:8125298
2293:4427026
2265:Bibcode
2232:3616158
2051:3401444
1893:4390343
1865:Bibcode
1833:2212036
1526:Ensembl
1073:[[File:
613:UniProt
568:Ensembl
507:Species
486:QuickGO
435:nucleus
209:pattern
70:1918976
38:Aliases
2792:
2782:
2749:
2720:
2710:
2675:
2665:
2632:
2624:
2598:Nature
2586:
2576:
2543:
2536:521670
2533:
2500:
2465:
2435:
2400:
2371:
2332:
2291:
2283:
2257:Nature
2239:
2229:
2194:
2149:
2111:
2103:
2058:
2048:
2009:
1968:
1932:
1891:
1883:
1857:Nature
1840:
1830:
1791:
1749:
1714:
1653:
1612:
1604:
972:uracil
961:enzyme
959:is an
915:search
913:PubMed
646:Q6P5C5
627:Q53HV7
523:Entrez
332:BioGPS
291:zygote
62:607753
2630:S2CID
2289:S2CID
2172:(PDF)
2109:S2CID
2081:(PDF)
1889:S2CID
1610:S2CID
1049:RBPMS
1047:with
965:SMUG1
556:71726
537:23583
516:Mouse
511:Human
482:Amigo
232:Mouse
225:Human
172:Start
107:Mouse
86:SMUG1
45:SMUG1
22:SMUG1
2790:PMID
2747:PMID
2718:PMID
2673:PMID
2622:PMID
2584:PMID
2541:PMID
2498:PMID
2463:PMID
2433:PMID
2398:PMID
2382:Gene
2369:PMID
2353:Gene
2330:PMID
2281:PMID
2237:PMID
2192:PMID
2147:PMID
2101:PMID
2056:PMID
2007:PMID
1966:PMID
1930:PMID
1881:PMID
1838:PMID
1789:PMID
1747:PMID
1712:PMID
1651:PMID
1602:PMID
1454:edit
1441:edit
1053:DKC1
1004:MBD4
1002:and
968:gene
215:Bgee
163:Band
124:Chr.
78:8629
58:OMIM
2780:PMC
2772:doi
2739:doi
2708:PMC
2698:doi
2663:PMC
2655:doi
2614:doi
2602:437
2574:PMC
2566:doi
2531:PMC
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