139:
116:
862:
family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delays lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking.
356:
349:
342:
145:
1486:
861:
This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS
152:
985:
Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG (November 2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking".
1097:"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro"
554:
535:
77:
1130:
Kosan C, Kunz J (2003). "Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region".
1234:
1555:
918:
1531:
900:
138:
787:
115:
1039:
887:
883:
1227:
57:
151:
144:
1524:
599:
65:
1220:
1095:
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998).
580:
1550:
1517:
994:
44:
765:
744:
740:
736:
726:
722:
718:
714:
690:
1155:
1083:
1018:
89:
710:
669:
1200:
1147:
1118:
1075:
1010:
967:
355:
348:
37:
1501:
1190:
1180:
1139:
1108:
1067:
1058:
Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins".
1002:
957:
949:
231:
162:
106:
1439:
1419:
1409:
1394:
1373:
1368:
1363:
1353:
1348:
1343:
1338:
1333:
1312:
1307:
1302:
341:
85:
1282:
206:
998:
962:
937:
1195:
1168:
469:
464:
459:
454:
438:
433:
428:
423:
407:
402:
397:
1544:
1243:
384:
1159:
1087:
1022:
69:
1497:
224:
93:
953:
923:
National Center for
Biotechnology Information, U.S. National Library of Medicine
905:
National Center for
Biotechnology Information, U.S. National Library of Medicine
264:
1460:
123:
73:
1113:
1096:
1455:
1006:
499:
190:
177:
81:
1204:
1185:
1151:
1079:
1014:
971:
1122:
938:"A large family of endosome-localized proteins related to sorting nexin 1"
827:
822:
1465:
811:
644:
625:
936:
Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001).
843:
611:
566:
1143:
1414:
795:
521:
1485:
1071:
1434:
1429:
1424:
1404:
1399:
1358:
1297:
1212:
484:
480:
1493:
1328:
1292:
1287:
1277:
1272:
1267:
1262:
1257:
850:
364:
61:
1216:
214:
1505:
331:
1448:
1382:
1321:
1250:
758:
709:
683:
662:
879:
877:
875:
161:
884:GRCm38: Ensembl release 89: ENSMUSG00000020590
1525:
1228:
8:
1169:"An unappreciated role for RNA surveillance"
1532:
1518:
1235:
1221:
1213:
706:
495:
460:negative regulation of signal transduction
380:
202:
101:
1194:
1184:
1167:Hillman RT, Green RE, Brenner SE (2005).
1112:
961:
1034:
1032:
403:phosphatidylinositol-3-phosphate binding
871:
1060:Nature Reviews. Molecular Cell Biology
470:positive regulation of GTPase activity
18:
1040:"Entrez Gene: SNX13 sorting nexin 13"
166:
127:
122:
7:
1482:
1480:
1504:. You can help Knowledge (XXG) by
755:
680:
659:
635:
616:
590:
571:
545:
526:
336:
259:
240:
219:
14:
846:that in humans is encoded by the
1484:
354:
347:
340:
150:
143:
137:
114:
16:Gene of the species Homo sapiens
1132:Cytogenetic and Genome Research
465:intracellular protein transport
365:More reference expression data
1:
1556:Human chromosome 7 gene stubs
135:
398:phosphatidylinositol binding
48:, RGS-PX1, sorting nexin 13
1572:
1479:
307:sternocleidomastoid muscle
954:10.1042/0264-6021:3580007
919:"Mouse PubMed Reference:"
901:"Human PubMed Reference:"
826:
821:
817:
810:
794:
777:
762:
733:
702:
687:
666:
655:
642:
638:
623:
619:
610:
597:
593:
578:
574:
565:
552:
548:
533:
529:
520:
505:
498:
494:
478:
383:
379:
362:
339:
330:
322:
271:
262:
247:
243:
213:
205:
201:
184:
171:
134:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1007:10.1126/science.1064757
942:The Biochemical Journal
434:early endosome membrane
279:vastus lateralis muscle
1186:10.1186/gb-2004-5-2-r8
1114:10.1093/dnares/5.5.277
788:Chr 12: 35.1 – 35.2 Mb
287:triceps brachii muscle
129:Chromosome 12 (mouse)
999:2001Sci...294.1939Z
1492:This article on a
600:ENSMUSG00000020590
448:Biological process
417:Cellular component
391:Molecular function
295:lobe of cerebellum
1513:
1512:
1474:
1473:
1144:10.1159/000066618
993:(5548): 1939–42.
837:
836:
833:
832:
806:
805:
773:
772:
752:
751:
698:
697:
677:
676:
651:
650:
632:
631:
606:
605:
587:
586:
561:
560:
542:
541:
490:
489:
455:protein transport
375:
374:
371:
370:
326:
325:
318:
317:
311:cerebellar vermis
256:
255:
197:
196:
94:SNX13 - orthologs
1563:
1534:
1527:
1520:
1488:
1481:
1449:Related articles
1237:
1230:
1223:
1214:
1208:
1198:
1188:
1163:
1126:
1116:
1091:
1044:
1043:
1036:
1027:
1026:
982:
976:
975:
965:
933:
927:
926:
915:
909:
908:
897:
891:
881:
840:Sorting nexin-13
819:
818:
790:
783:
768:
756:
747:
707:
703:RefSeq (protein)
693:
681:
672:
660:
636:
617:
591:
572:
546:
527:
496:
381:
367:
358:
351:
344:
337:
267:
265:Top expressed in
260:
241:
220:
203:
193:
180:
169:
154:
147:
141:
130:
118:
102:
96:
47:
40:
19:
1571:
1570:
1566:
1565:
1564:
1562:
1561:
1560:
1541:
1540:
1539:
1538:
1477:
1475:
1470:
1444:
1378:
1317:
1246:
1241:
1211:
1166:
1138:(3–4): 167–70.
1129:
1094:
1057:
1053:
1051:Further reading
1048:
1047:
1038:
1037:
1030:
984:
983:
979:
935:
934:
930:
917:
916:
912:
899:
898:
894:
882:
873:
868:
859:
828:View/Edit Mouse
823:View/Edit Human
786:
781:
778:Location (UCSC)
764:
743:
739:
735:
729:
725:
721:
717:
713:
689:
668:
581:ENSG00000071189
474:
443:
412:
363:
353:
352:
346:
345:
314:
309:
305:
301:
299:temporal muscle
297:
293:
289:
285:
281:
277:
263:
252:
188:
175:
167:
157:
156:
155:
148:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
1569:
1567:
1559:
1558:
1553:
1543:
1542:
1537:
1536:
1529:
1522:
1514:
1511:
1510:
1489:
1472:
1471:
1469:
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1463:
1458:
1452:
1450:
1446:
1445:
1443:
1442:
1437:
1432:
1427:
1422:
1417:
1412:
1407:
1402:
1397:
1392:
1386:
1384:
1380:
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1376:
1371:
1366:
1361:
1356:
1351:
1346:
1341:
1336:
1331:
1325:
1323:
1319:
1318:
1316:
1315:
1310:
1305:
1300:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1254:
1252:
1248:
1247:
1244:Sorting nexins
1242:
1240:
1239:
1232:
1225:
1217:
1210:
1209:
1173:Genome Biology
1164:
1127:
1092:
1072:10.1038/nrm974
1066:(12): 919–31.
1054:
1052:
1049:
1046:
1045:
1028:
977:
948:(Pt 1): 7–16.
928:
910:
892:
870:
869:
867:
864:
858:
855:
835:
834:
831:
830:
825:
815:
814:
808:
807:
804:
803:
801:
799:
792:
791:
784:
779:
775:
774:
771:
770:
760:
759:
753:
750:
749:
731:
730:
704:
700:
699:
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695:
685:
684:
678:
675:
674:
664:
663:
657:
653:
652:
649:
648:
640:
639:
633:
630:
629:
621:
620:
614:
608:
607:
604:
603:
595:
594:
588:
585:
584:
576:
575:
569:
563:
562:
559:
558:
550:
549:
543:
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531:
530:
524:
518:
517:
512:
507:
503:
502:
492:
491:
488:
487:
476:
475:
473:
472:
467:
462:
457:
451:
449:
445:
444:
442:
441:
436:
431:
429:early endosome
426:
420:
418:
414:
413:
411:
410:
405:
400:
394:
392:
388:
387:
377:
376:
373:
372:
369:
368:
360:
359:
334:
328:
327:
324:
323:
320:
319:
316:
315:
313:
312:
308:
304:
303:lacrimal gland
300:
296:
292:
288:
284:
280:
276:
272:
269:
268:
257:
254:
253:
251:
248:
245:
244:
237:
236:
228:
217:
211:
210:
207:RNA expression
199:
198:
195:
194:
186:
182:
181:
173:
170:
165:
159:
158:
149:
142:
136:
132:
131:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1568:
1557:
1554:
1552:
1549:
1548:
1546:
1535:
1530:
1528:
1523:
1521:
1516:
1515:
1509:
1507:
1503:
1499:
1495:
1490:
1487:
1483:
1478:
1467:
1464:
1462:
1459:
1457:
1454:
1453:
1451:
1447:
1441:
1438:
1436:
1433:
1431:
1428:
1426:
1423:
1421:
1418:
1416:
1413:
1411:
1408:
1406:
1403:
1401:
1398:
1396:
1393:
1391:
1388:
1387:
1385:
1381:
1375:
1372:
1370:
1367:
1365:
1362:
1360:
1357:
1355:
1352:
1350:
1347:
1345:
1342:
1340:
1337:
1335:
1332:
1330:
1327:
1326:
1324:
1320:
1314:
1311:
1309:
1306:
1304:
1301:
1299:
1296:
1294:
1291:
1289:
1286:
1284:
1281:
1279:
1276:
1274:
1271:
1269:
1266:
1264:
1261:
1259:
1256:
1255:
1253:
1249:
1245:
1238:
1233:
1231:
1226:
1224:
1219:
1218:
1215:
1206:
1202:
1197:
1192:
1187:
1182:
1178:
1174:
1170:
1165:
1161:
1157:
1153:
1149:
1145:
1141:
1137:
1133:
1128:
1124:
1120:
1115:
1110:
1107:(5): 277–86.
1106:
1102:
1098:
1093:
1089:
1085:
1081:
1077:
1073:
1069:
1065:
1061:
1056:
1055:
1050:
1041:
1035:
1033:
1029:
1024:
1020:
1016:
1012:
1008:
1004:
1000:
996:
992:
988:
981:
978:
973:
969:
964:
959:
955:
951:
947:
943:
939:
932:
929:
924:
920:
914:
911:
906:
902:
896:
893:
889:
885:
880:
878:
876:
872:
865:
863:
856:
854:
852:
849:
845:
841:
829:
824:
820:
816:
813:
809:
802:
800:
797:
793:
789:
785:
780:
776:
769:
767:
761:
757:
754:
748:
746:
742:
738:
732:
728:
724:
720:
716:
712:
708:
705:
701:
694:
692:
686:
682:
679:
673:
671:
665:
661:
658:
656:RefSeq (mRNA)
654:
647:
646:
641:
637:
634:
628:
627:
622:
618:
615:
613:
609:
602:
601:
596:
592:
589:
583:
582:
577:
573:
570:
568:
564:
557:
556:
551:
547:
544:
538:
537:
532:
528:
525:
523:
519:
516:
513:
511:
508:
504:
501:
497:
493:
486:
482:
477:
471:
468:
466:
463:
461:
458:
456:
453:
452:
450:
447:
446:
440:
437:
435:
432:
430:
427:
425:
422:
421:
419:
416:
415:
409:
408:lipid binding
406:
404:
401:
399:
396:
395:
393:
390:
389:
386:
385:Gene ontology
382:
378:
366:
361:
357:
350:
343:
338:
335:
333:
329:
321:
310:
306:
302:
298:
294:
290:
286:
283:otolith organ
282:
278:
275:parotid gland
274:
273:
270:
266:
261:
258:
249:
246:
242:
239:
238:
235:
233:
229:
227:
226:
222:
221:
218:
216:
212:
208:
204:
200:
192:
187:
183:
179:
174:
168:12|12 A3
164:
160:
153:
146:
140:
133:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
1506:expanding it
1498:chromosome 7
1491:
1476:
1389:
1176:
1172:
1135:
1131:
1104:
1101:DNA Research
1100:
1063:
1059:
990:
986:
980:
945:
941:
931:
922:
913:
904:
895:
860:
847:
839:
838:
766:NP_001014973
763:
745:NP_001337799
741:NP_001337797
737:NP_001337796
734:
727:NP_001337795
723:NP_001337793
719:NP_001337792
715:NP_001337791
691:NM_001014973
688:
667:
643:
624:
598:
579:
553:
534:
514:
509:
230:
223:
53:External IDs
1551:Human genes
189:35,197,478
176:35,097,185
31:Identifiers
1545:Categories
1461:BAR domain
890:, May 2017
866:References
234:(ortholog)
74:HomoloGene
1496:on human
1456:PX domain
1383:SNX-Other
1179:(2): R8.
711:NP_055947
670:NM_015132
500:Orthologs
82:GeneCards
1466:Retromer
1205:14759258
1160:27223779
1152:12438708
1088:36361630
1080:12461558
1023:85169394
1015:11729322
972:11485546
886:–
857:Function
812:Wikidata
479:Sources:
439:membrane
424:endosome
1251:SNX-BAR
1123:9872452
995:Bibcode
987:Science
963:1222026
888:Ensembl
844:protein
612:UniProt
567:Ensembl
506:Species
485:QuickGO
291:utricle
209:pattern
70:2661416
38:Aliases
1322:SNX-PX
1203:
1196:395752
1193:
1158:
1150:
1121:
1086:
1078:
1021:
1013:
970:
960:
798:search
796:PubMed
645:Q6PHS6
626:Q9Y5W8
555:217463
522:Entrez
332:BioGPS
62:606589
1500:is a
1440:SNX31
1435:SNX28
1430:SNX27
1425:SNX26
1420:SNX25
1415:SNX23
1410:SNX19
1405:SNX17
1400:SNX15
1395:SNX14
1390:SNX13
1374:SNX29
1369:SNX24
1364:SNX22
1359:SNX21
1354:SNX20
1349:SNX16
1344:SNX12
1339:SNX11
1334:SNX10
1313:SNX33
1308:SNX32
1303:SNX30
1298:SNX18
1156:S2CID
1084:S2CID
1019:S2CID
848:SNX13
842:is a
536:23161
515:Mouse
510:Human
481:Amigo
232:Mouse
225:Human
172:Start
107:Mouse
86:SNX13
78:41011
45:SNX13
22:SNX13
1502:stub
1494:gene
1329:SNX3
1293:SNX9
1288:SNX8
1283:SNX7
1278:SNX6
1273:SNX5
1268:SNX4
1263:SNX2
1258:SNX1
1201:PMID
1148:PMID
1119:PMID
1076:PMID
1011:PMID
968:PMID
851:gene
215:Bgee
163:Band
124:Chr.
58:OMIM
1191:PMC
1181:doi
1140:doi
1109:doi
1068:doi
1003:doi
991:294
958:PMC
950:doi
946:358
782:n/a
250:n/a
185:End
90:OMA
66:MGI
1547::
1199:.
1189:.
1175:.
1171:.
1154:.
1146:.
1136:97
1134:.
1117:.
1103:.
1099:.
1082:.
1074:.
1062:.
1031:^
1017:.
1009:.
1001:.
989:.
966:.
956:.
944:.
940:.
921:.
903:.
874:^
853:.
483:/
191:bp
178:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
1533:e
1526:t
1519:v
1508:.
1236:e
1229:t
1222:v
1207:.
1183::
1177:5
1162:.
1142::
1125:.
1111::
1105:5
1090:.
1070::
1064:3
1042:.
1025:.
1005::
997::
974:.
952::
925:.
907:.
109:)
92::
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