297:
274:
171:
196:
555:
548:
303:
202:
1989:
50:
1222:
Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, Wakioka T, Tanimura S, Sasaki A, Misawa H, Yokouchi M, Ohtsubo M, Yoshimura A (Nov 1997). "Cloning and characterization of novel CIS family genes".
1692:
1258:
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000).
310:
209:
1641:
Hwang MN, Min CH, Kim HS, et al. (2007). "The nuclear localization of SOCS6 requires the N-terminal region and negatively regulates Stat3 protein levels".
1612:
Hwang MN, Ha TH, Park J, et al. (2007). "Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via
Pkcdelta activation".
1260:"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells"
1360:"Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance"
803:
784:
132:
1685:
2058:
2034:
2053:
1204:
1186:
1524:
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells".
296:
1835:
1678:
1783:
1007:
1014:
273:
1868:
1310:
1173:
1152:
195:
170:
1169:
47:
1921:
1148:
1116:
112:
309:
208:
2027:
1701:
302:
201:
1740:
1395:"SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation"
1735:
1329:
Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation".
848:
120:
1571:"The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins"
829:
2020:
1709:
184:
103:, CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4, suppressor of cytokine signaling 6
1533:
1449:
99:
1100:
1600:
1557:
1112:
144:
1438:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
990:
969:
943:
922:
918:
1773:
1727:
1658:
1629:
1592:
1549:
1512:
1477:
1424:
1381:
1346:
1289:
1240:
92:
40:
2004:
1491:"Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling"
1650:
1621:
1582:
1541:
1502:
1467:
1457:
1414:
1406:
1371:
1338:
1279:
1271:
1232:
389:
320:
264:
219:
554:
547:
140:
1120:
364:
1537:
1453:
1768:
1763:
1758:
1108:
1096:
1472:
1437:
1419:
1394:
1342:
1284:
1259:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
658:
653:
637:
632:
627:
622:
606:
601:
596:
2047:
2000:
1410:
583:
1604:
1561:
124:
1792:
1750:
382:
161:
1587:
1570:
148:
1911:
1209:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1191:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1654:
1625:
465:
1084:
281:
178:
128:
1670:
1545:
1124:
748:
525:
403:
348:
335:
247:
234:
136:
1662:
1633:
1596:
1553:
1516:
1507:
1490:
1481:
1462:
1428:
1385:
1376:
1359:
1350:
1293:
1236:
1244:
1054:
1049:
1717:
1088:
1038:
893:
874:
1115:. A high expression level of this gene was found in factor-independent
1070:
860:
815:
1275:
69:
1104:
1103:
of cytokine signaling. The expression of this gene can be induced by
1022:
770:
1988:
1906:
1896:
1891:
1886:
1881:
1876:
1858:
1853:
1848:
1843:
1825:
1820:
1815:
1810:
1805:
1800:
733:
729:
1996:
1964:
1959:
1954:
1949:
1944:
1939:
1934:
1929:
1092:
1077:
116:
1674:
563:
704:
negative regulation of receptor signaling pathway via JAK-STAT
1436:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1087:
and a CIS homolog domain. The protein thus belongs to the
1099:. CIS family members are known to be cytokine-inducible
372:
2008:
1311:"Entrez Gene: SOCS6 suppressor of cytokine signaling 6"
537:
714:
regulation of phosphatidylinositol 3-kinase activity
1920:
1867:
1834:
1791:
1782:
1749:
1726:
1708:
983:
962:
936:
911:
719:
phosphatidylinositol phosphate biosynthetic process
1393:Krebs DL, Uren RT, Metcalf D, et al. (2002).
1358:Mooney RA, Senn J, Cameron S, et al. (2001).
1165:
1163:
1161:
1144:
1142:
1140:
607:1-phosphatidylinositol-3-kinase regulator activity
319:
218:
1489:Bayle J, Letard S, Frank R, et al. (2004).
16:Protein-coding gene in the species Homo sapiens
1569:Bayle J, Lopez S, Iwaï K, et al. (2006).
1170:GRCm38: Ensembl release 89: ENSMUSG00000056153
694:negative regulation of protein kinase activity
2028:
1686:
1091:-induced STAT inhibitor (CIS), also known as
8:
1095:(SOCS) or STAT-induced STAT inhibitor (SSI)
1083:The protein encoded by this gene contains a
1149:GRCh38: Ensembl release 89: ENSG00000170677
2035:
2021:
1788:
1693:
1679:
1671:
744:
674:negative regulation of signal transduction
579:
422:Skeletal muscle tissue of rectus abdominis
360:
259:
156:
58:
1586:
1506:
1471:
1461:
1418:
1375:
1283:
1305:
1303:
684:negative regulation of T cell activation
442:Skeletal muscle tissue of biceps brachii
1136:
709:post-translational protein modification
669:receptor signaling pathway via JAK-STAT
18:
664:proteasomal protein catabolic process
638:phosphatidylinositol 3-kinase complex
324:
285:
280:
223:
182:
177:
7:
1985:
1983:
699:cytokine-mediated signaling pathway
2007:. You can help Knowledge (XXG) by
1067:Suppressor of cytokine signaling 6
980:
959:
933:
908:
884:
865:
839:
820:
794:
775:
542:
460:
398:
377:
14:
1073:that in humans is encoded by the
679:intracellular signal transduction
597:protein kinase inhibitor activity
1987:
1411:10.1128/MCB.22.13.4567-4578.2002
1093:suppressor of cytokine signaling
553:
546:
308:
301:
295:
272:
207:
200:
194:
169:
2059:Human chromosome 18 gene stubs
564:More reference expression data
526:More reference expression data
1:
1643:Biochem. Biophys. Res. Commun
1614:Biochem. Biophys. Res. Commun
1588:10.1016/j.febslet.2006.03.093
1343:10.1016/S0968-0004(02)02085-6
293:
192:
2054:Genes on human chromosome 18
1442:Proc. Natl. Acad. Sci. U.S.A
1117:chronic myelogenous leukemia
2075:
1982:
1702:JAK-STAT signaling pathway
1655:10.1016/j.bbrc.2007.06.062
1626:10.1016/j.bbrc.2006.12.175
1225:Biochem Biophys Res Commun
1741:Type II cytokine receptor
1205:"Mouse PubMed Reference:"
1187:"Human PubMed Reference:"
1053:
1048:
1044:
1037:
1021:
1002:
987:
966:
955:
940:
915:
904:
891:
887:
872:
868:
859:
846:
842:
827:
823:
814:
801:
797:
782:
778:
769:
754:
747:
743:
727:
582:
578:
561:
545:
536:
523:
512:medial geniculate nucleus
472:
463:
414:mucosa of paranasal sinus
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1736:Type I cytokine receptor
1015:Chr 18: 88.68 – 88.95 Mb
1008:Chr 18: 70.29 – 70.33 Mb
1546:10.1126/science.1105776
438:mucosa of sigmoid colon
1508:10.1074/jbc.M313381200
1463:10.1073/pnas.242603899
1377:10.1074/jbc.M010579200
1237:10.1006/bbrc.1997.7484
689:protein ubiquitination
628:immunological synapse
287:Chromosome 18 (mouse)
185:Chromosome 18 (human)
654:regulation of growth
62:List of PDB id codes
35:Available structures
1538:2005Sci...307.1621B
1454:2002PNAS...9916899M
1331:Trends Biochem. Sci
1113:hematopoietic cells
1101:negative regulators
1995:This article on a
849:ENSMUSG00000056153
647:Biological process
616:Cellular component
590:Molecular function
504:intercostal muscle
2016:
2015:
1977:
1976:
1973:
1972:
1728:Cytokine receptor
1448:(26): 16899–903.
1276:10.1101/gr.140200
1064:
1063:
1060:
1059:
1033:
1032:
998:
997:
977:
976:
951:
950:
930:
929:
900:
899:
881:
880:
855:
854:
836:
835:
810:
809:
791:
790:
739:
738:
574:
573:
570:
569:
532:
531:
519:
518:
457:
456:
355:
354:
254:
253:
149:SOCS6 - orthologs
81:
80:
77:
76:
45:Ortholog search:
2066:
2037:
2030:
2023:
1991:
1984:
1789:
1784:Adaptor proteins
1695:
1688:
1681:
1672:
1666:
1637:
1608:
1590:
1565:
1532:(5715): 1621–5.
1520:
1510:
1501:(13): 12249–59.
1485:
1475:
1465:
1432:
1422:
1389:
1379:
1370:(28): 25889–93.
1354:
1315:
1314:
1307:
1298:
1297:
1287:
1255:
1249:
1248:
1219:
1213:
1212:
1201:
1195:
1194:
1183:
1177:
1167:
1156:
1146:
1046:
1045:
1017:
1010:
993:
981:
972:
960:
956:RefSeq (protein)
946:
934:
925:
909:
885:
866:
840:
821:
795:
776:
745:
659:defense response
580:
566:
557:
550:
543:
528:
492:secondary oocyte
468:
466:Top expressed in
461:
450:caput epididymis
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
2074:
2073:
2069:
2068:
2067:
2065:
2064:
2063:
2044:
2043:
2042:
2041:
1980:
1978:
1969:
1916:
1863:
1830:
1778:
1745:
1722:
1704:
1699:
1669:
1640:
1611:
1581:(11): 2609–14.
1568:
1523:
1488:
1435:
1405:(13): 4567–78.
1399:Mol. Cell. Biol
1392:
1357:
1328:
1324:
1322:Further reading
1319:
1318:
1309:
1308:
1301:
1270:(10): 1546–60.
1257:
1256:
1252:
1221:
1220:
1216:
1203:
1202:
1198:
1185:
1184:
1180:
1168:
1159:
1147:
1138:
1133:
1121:erythroleukemia
1055:View/Edit Mouse
1050:View/Edit Human
1013:
1006:
1003:Location (UCSC)
989:
968:
942:
921:
917:
830:ENSG00000170677
723:
642:
611:
602:protein binding
562:
552:
551:
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
446:right ventricle
444:
440:
436:
434:mucosa of colon
432:
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
2072:
2070:
2062:
2061:
2056:
2046:
2045:
2040:
2039:
2032:
2025:
2017:
2014:
2013:
1992:
1975:
1974:
1971:
1970:
1968:
1967:
1962:
1957:
1952:
1947:
1942:
1937:
1932:
1926:
1924:
1918:
1917:
1915:
1914:
1909:
1904:
1899:
1894:
1889:
1884:
1879:
1873:
1871:
1865:
1864:
1862:
1861:
1856:
1851:
1846:
1840:
1838:
1832:
1831:
1829:
1828:
1823:
1818:
1813:
1808:
1803:
1797:
1795:
1786:
1780:
1779:
1777:
1776:
1771:
1766:
1761:
1755:
1753:
1747:
1746:
1744:
1743:
1738:
1732:
1730:
1724:
1723:
1721:
1720:
1714:
1712:
1706:
1705:
1700:
1698:
1697:
1690:
1683:
1675:
1668:
1667:
1638:
1609:
1566:
1521:
1486:
1433:
1390:
1355:
1325:
1323:
1320:
1317:
1316:
1299:
1250:
1214:
1196:
1178:
1157:
1135:
1134:
1132:
1129:
1097:protein family
1062:
1061:
1058:
1057:
1052:
1042:
1041:
1035:
1034:
1031:
1030:
1028:
1026:
1019:
1018:
1011:
1004:
1000:
999:
996:
995:
985:
984:
978:
975:
974:
964:
963:
957:
953:
952:
949:
948:
938:
937:
931:
928:
927:
913:
912:
906:
902:
901:
898:
897:
889:
888:
882:
879:
878:
870:
869:
863:
857:
856:
853:
852:
844:
843:
837:
834:
833:
825:
824:
818:
812:
811:
808:
807:
799:
798:
792:
789:
788:
780:
779:
773:
767:
766:
761:
756:
752:
751:
741:
740:
737:
736:
725:
724:
722:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
650:
648:
644:
643:
641:
640:
635:
630:
625:
619:
617:
613:
612:
610:
609:
604:
599:
593:
591:
587:
586:
576:
575:
572:
571:
568:
567:
559:
558:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
426:jejunal mucosa
423:
419:
418:biceps brachii
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2071:
2060:
2057:
2055:
2052:
2051:
2049:
2038:
2033:
2031:
2026:
2024:
2019:
2018:
2012:
2010:
2006:
2002:
2001:chromosome 18
1998:
1993:
1990:
1986:
1981:
1966:
1963:
1961:
1958:
1956:
1953:
1951:
1948:
1946:
1943:
1941:
1938:
1936:
1933:
1931:
1928:
1927:
1925:
1923:
1919:
1913:
1910:
1908:
1905:
1903:
1900:
1898:
1895:
1893:
1890:
1888:
1885:
1883:
1880:
1878:
1875:
1874:
1872:
1870:
1866:
1860:
1857:
1855:
1852:
1850:
1847:
1845:
1842:
1841:
1839:
1837:
1833:
1827:
1824:
1822:
1819:
1817:
1814:
1812:
1809:
1807:
1804:
1802:
1799:
1798:
1796:
1794:
1790:
1787:
1785:
1781:
1775:
1772:
1770:
1767:
1765:
1762:
1760:
1757:
1756:
1754:
1752:
1748:
1742:
1739:
1737:
1734:
1733:
1731:
1729:
1725:
1719:
1716:
1715:
1713:
1711:
1707:
1703:
1696:
1691:
1689:
1684:
1682:
1677:
1676:
1673:
1664:
1660:
1656:
1652:
1648:
1644:
1639:
1635:
1631:
1627:
1623:
1619:
1615:
1610:
1606:
1602:
1598:
1594:
1589:
1584:
1580:
1576:
1572:
1567:
1563:
1559:
1555:
1551:
1547:
1543:
1539:
1535:
1531:
1527:
1522:
1518:
1514:
1509:
1504:
1500:
1496:
1495:J. Biol. Chem
1492:
1487:
1483:
1479:
1474:
1469:
1464:
1459:
1455:
1451:
1447:
1443:
1439:
1434:
1430:
1426:
1421:
1416:
1412:
1408:
1404:
1400:
1396:
1391:
1387:
1383:
1378:
1373:
1369:
1365:
1364:J. Biol. Chem
1361:
1356:
1352:
1348:
1344:
1340:
1337:(5): 235–41.
1336:
1332:
1327:
1326:
1321:
1312:
1306:
1304:
1300:
1295:
1291:
1286:
1281:
1277:
1273:
1269:
1265:
1261:
1254:
1251:
1246:
1242:
1238:
1234:
1231:(2): 439–46.
1230:
1226:
1218:
1215:
1210:
1206:
1200:
1197:
1192:
1188:
1182:
1179:
1175:
1171:
1166:
1164:
1162:
1158:
1154:
1150:
1145:
1143:
1141:
1137:
1130:
1128:
1126:
1122:
1118:
1114:
1110:
1106:
1102:
1098:
1094:
1090:
1086:
1081:
1079:
1076:
1072:
1068:
1056:
1051:
1047:
1043:
1040:
1036:
1029:
1027:
1024:
1020:
1016:
1012:
1009:
1005:
1001:
994:
992:
986:
982:
979:
973:
971:
965:
961:
958:
954:
947:
945:
939:
935:
932:
926:
924:
920:
914:
910:
907:
905:RefSeq (mRNA)
903:
896:
895:
890:
886:
883:
877:
876:
871:
867:
864:
862:
858:
851:
850:
845:
841:
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832:
831:
826:
822:
819:
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800:
796:
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746:
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731:
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631:
629:
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621:
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618:
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608:
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603:
600:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
549:
544:
541:
539:
535:
527:
522:
511:
508:soleus muscle
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
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326:18|18 E4
322:
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279:
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94:
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73:
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52:
49:
42:
38:
33:
29:
25:
20:
2009:expanding it
1994:
1979:
1901:
1751:Janus kinase
1649:(2): 333–8.
1646:
1642:
1620:(1): 184–9.
1617:
1613:
1578:
1574:
1529:
1525:
1498:
1494:
1445:
1441:
1402:
1398:
1367:
1363:
1334:
1330:
1267:
1263:
1253:
1228:
1224:
1217:
1208:
1199:
1190:
1181:
1082:
1074:
1066:
1065:
988:
967:
941:
916:
892:
873:
847:
828:
802:
783:
763:
758:
496:pineal gland
480:otic placode
476:otic vesicle
388:
381:
108:External IDs
67:
430:oral cavity
347:88,945,605
334:88,683,348
246:70,330,199
233:70,289,045
86:Identifiers
2048:Categories
1264:Genome Res
1176:, May 2017
1155:, May 2017
1131:References
1125:cell lines
1119:(CML) and
1085:SH2 domain
392:(ortholog)
129:HomoloGene
1999:on human
1575:FEBS Lett
991:NP_061291
970:NP_004223
944:NM_018821
923:NM_016387
919:NM_004232
749:Orthologs
623:cytoplasm
137:GeneCards
1718:Cytokine
1663:17603019
1634:17210122
1605:44648698
1597:16643902
1562:39457788
1554:15761153
1517:14707129
1482:12477932
1429:12052866
1386:11342531
1351:12076535
1294:11042152
1172:–
1151:–
1089:cytokine
1039:Wikidata
728:Sources:
500:yolk sac
1534:Bibcode
1526:Science
1450:Bibcode
1245:9344848
1174:Ensembl
1153:Ensembl
1071:protein
861:UniProt
816:Ensembl
755:Species
734:QuickGO
633:cytosol
488:saccule
367:pattern
225:18q22.2
125:1924885
93:Aliases
1710:Ligand
1661:
1632:
1603:
1595:
1560:
1552:
1515:
1480:
1473:139241
1470:
1427:
1420:133908
1417:
1384:
1349:
1292:
1285:310934
1282:
1243:
1123:(HEL)
1105:GM-CSF
1025:search
1023:PubMed
894:Q9JLY0
875:O14544
771:Entrez
538:BioGPS
484:zygote
117:605118
2003:is a
1859:PIAS4
1854:PIAS3
1849:PIAS2
1844:PIAS1
1826:STAT6
1821:STAT5
1816:STAT4
1811:STAT3
1806:STAT2
1801:STAT1
1601:S2CID
1558:S2CID
1075:SOCS6
1069:is a
804:54607
764:Mouse
759:Human
730:Amigo
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
141:SOCS6
100:SOCS6
22:SOCS6
2005:stub
1997:gene
1965:IRF8
1960:IRF7
1955:IRF6
1950:IRF5
1945:IRF4
1940:IRF3
1935:IRF2
1930:IRF1
1912:CISH
1869:SOCS
1836:PIAS
1793:STAT
1774:TYK2
1769:JAK3
1764:JAK2
1759:JAK1
1659:PMID
1630:PMID
1593:PMID
1550:PMID
1513:PMID
1478:PMID
1425:PMID
1382:PMID
1347:PMID
1290:PMID
1241:PMID
1107:and
1078:gene
785:9306
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
133:3120
113:OMIM
70:2VIF
51:RCSB
48:PDBe
1922:IRF
1651:doi
1647:360
1622:doi
1618:354
1583:doi
1579:580
1542:doi
1530:307
1503:doi
1499:279
1468:PMC
1458:doi
1415:PMC
1407:doi
1372:doi
1368:276
1339:doi
1280:PMC
1272:doi
1233:doi
1229:239
1111:in
1109:EPO
343:End
242:End
145:OMA
121:MGI
41:PDB
2050::
1657:.
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1591:.
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1573:.
1556:.
1548:.
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1456:.
1446:99
1444:.
1440:.
1423:.
1413:.
1403:22
1401:.
1397:.
1380:.
1366:.
1362:.
1345:.
1335:27
1333:.
1302:^
1288:.
1278:.
1268:10
1266:.
1262:.
1239:.
1227:.
1207:.
1189:.
1160:^
1139:^
1127:.
1080:.
732:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
2036:e
2029:t
2022:v
2011:.
1907:7
1902:6
1897:5
1892:4
1887:3
1882:2
1877:1
1694:e
1687:t
1680:v
1665:.
1653::
1636:.
1624::
1607:.
1585::
1564:.
1544::
1536::
1519:.
1505::
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1460::
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1313:.
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1274::
1247:.
1235::
1211:.
1193:.
267:)
164:)
147::
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