310:
287:
184:
209:
561:
568:
316:
215:
29:
1982:
1967:
1997:
2022:
55:
1450:
Alvarez A, Martínez A, Ibarra B, et al. (1993). "Membrane-bound sorbitol dehydrogenase in human red blood cells. Studies in normal subjects and in enzyme-deficient subjects with congenital cataracts".
1855:"Catalytic mechanism of Zn2+-dependent polyol dehydrogenases: kinetic comparison of sheep liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase"
1642:
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides".
1845:
323:
222:
1421:
Lee FK, Cheung MC, Chung S (1994). "The human sorbitol dehydrogenase gene: cDNA cloning, sequence determination, and mapping by fluorescence in situ hybridization".
1523:
Carr IM, Whitehouse A, Coletta PL, Markham AF (1999). "Structural and evolutionary characterization of the human sorbitol dehydrogenase gene duplication".
1326:
Karlsson C, Maret W, Auld DS, et al. (1990). "Variability within mammalian sorbitol dehydrogenases. The primary structure of the human liver enzyme".
1613:
Darmanin C, Iwata T, Carper DA, et al. (2003). "Expression, purification and preliminary crystallographic analysis of human sorbitol dehydrogenase".
871:
145:
852:
1392:
Lee FK, Lee AY, Lin CX, et al. (1995). "Cloning, sequencing, and determination of the sites of expression of mouse sorbitol dehydrogenase cDNA".
2091:
2067:
2086:
1946:
1221:
1203:
309:
1078:
1071:
1757:
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin".
1794:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
286:
1278:
1190:
1169:
208:
183:
1186:
1981:
52:
1966:
1165:
125:
1355:
Samanta BK, Chandra NC, Ghosh S, Mukherjee KL (1985). "Aldose metabolism in developing human fetal brain and liver".
322:
221:
2060:
1939:
315:
214:
1996:
916:
133:
1716:"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)"
1297:
El-Kabbani O, Darmanin C, Chung RP (2004). "Sorbitol dehydrogenase: structure, function and ligand design".
897:
2053:
1839:
197:
1932:
1803:
1573:
112:
1239:
Iwata T, Popescu NC, Zimonjic DB, Karlsson C, Hoog JO, Vaca G, Rodriguez IR, Carper D (Jul 1995).
1827:
1782:
1667:
1548:
1476:
1380:
157:
1562:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
1054:
1033:
1007:
986:
1904:
1884:
1819:
1774:
1745:
1702:
1659:
1630:
1601:
1540:
1511:
1468:
1438:
1409:
1372:
1343:
1314:
1260:
105:
45:
2037:
1874:
1866:
1811:
1766:
1735:
1727:
1692:
1651:
1622:
1591:
1581:
1532:
1501:
1460:
1430:
1401:
1364:
1335:
1306:
1252:
560:
402:
333:
277:
232:
1490:"Identification and characterisation of a sequence related to human sorbitol dehydrogenase"
567:
377:
153:
1807:
1577:
1879:
1854:
1405:
1339:
1740:
1715:
1697:
1680:
1596:
1561:
786:
781:
776:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
710:
705:
700:
695:
690:
685:
680:
675:
670:
654:
649:
644:
639:
634:
629:
624:
619:
614:
609:
28:
2080:
2033:
1913:
1506:
1489:
1256:
596:
1671:
1552:
1831:
1786:
1480:
1384:
395:
174:
137:
161:
1770:
1226:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1208:
National Center for
Biotechnology Information, U.S. National Library of Medicine
478:
1626:
294:
191:
141:
1310:
1681:"X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase"
816:
538:
416:
361:
348:
260:
247:
149:
1888:
1823:
1778:
1749:
1706:
1663:
1634:
1605:
1586:
1434:
1318:
1544:
1536:
1515:
1472:
1442:
1413:
1376:
1347:
1264:
1118:
1113:
1241:"Structural organization of the human sorbitol dehydrogenase gene (SORD)"
1102:
961:
942:
1815:
1918:
1908:
1870:
1731:
1464:
1368:
928:
883:
82:
78:
74:
1134:
1086:
838:
2021:
1240:
1655:
801:
797:
2029:
1141:
129:
116:, HEL-S-95n, SORD1, sorbitol dehydrogenase, XDH, RDH, SDH, SORDD
1928:
576:
1924:
1903:
Overview of all the structural information available in the
1560:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
385:
2041:
1714:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
752:
glucuronate catabolic process to xylulose 5-phosphate
550:
1679:
Pauly TA, Ekstrom JL, Beebe DA, et al. (2004).
1047:
1026:
1000:
979:
1182:
1180:
1178:
1161:
1159:
1157:
332:
231:
16:Protein-coding gene in the species Homo sapiens
1187:GRCm38: Ensembl release 89: ENSMUSG00000027227
2061:
1940:
1844:: CS1 maint: DOI inactive as of April 2024 (
8:
1166:GRCh38: Ensembl release 89: ENSG00000140263
2068:
2054:
1947:
1933:
1925:
1853:Klimacek M, Hellmer H, Nidetzky B (2007).
1279:"Entrez Gene: SORD sorbitol dehydrogenase"
812:
592:
373:
272:
169:
63:
1878:
1739:
1696:
1595:
1585:
1505:
1488:Carr IM, Markham AF, Coletta PL (1997).
1962:
1153:
650:(R,R)-butanediol dehydrogenase activity
1837:
18:
337:
298:
293:
236:
195:
190:
7:
2018:
2016:
1990:: Human Sorbitol Dehydrogenase (apo)
2040:. You can help Knowledge (XXG) by
1975:: Human SDH/NADH/inhibitor complex
1406:10.1111/j.1432-1033.1995.tb20656.x
1340:10.1111/j.1432-1033.1989.tb15240.x
1044:
1023:
997:
976:
952:
933:
907:
888:
862:
843:
555:
473:
411:
390:
14:
1137:that in humans is encoded by the
625:L-iditol 2-dehydrogenase activity
2020:
1995:
1980:
1965:
1917:(Sorbitol dehydrogenase) at the
1507:10.1111/j.1432-1033.1997.00760.x
655:ribitol 2-dehydrogenase activity
566:
559:
321:
314:
308:
285:
220:
213:
207:
182:
27:
2092:Human chromosome 15 gene stubs
577:More reference expression data
539:More reference expression data
439:olfactory zone of nasal mucosa
1:
1759:J. Steroid Biochem. Mol. Biol
1698:10.1016/S0969-2126(03)00167-9
747:fructose biosynthetic process
635:D-xylulose reductase activity
306:
205:
2087:Genes on human chromosome 15
1566:Proc. Natl. Acad. Sci. U.S.A
1257:10.1016/0888-7543(95)80082-W
1771:10.1016/j.jsbmb.2005.01.007
777:L-xylitol catabolic process
767:response to nutrient levels
762:L-xylitol metabolic process
427:right lobe of thyroid gland
2108:
2015:
787:sorbitol metabolic process
757:response to osmotic stress
742:sorbitol catabolic process
727:flagellated sperm motility
431:left lobe of thyroid gland
1960:
1627:10.1107/S0907444903000441
1222:"Mouse PubMed Reference:"
1204:"Human PubMed Reference:"
1117:
1112:
1108:
1101:
1085:
1066:
1051:
1030:
1019:
1004:
983:
972:
959:
955:
940:
936:
927:
914:
910:
895:
891:
882:
869:
865:
850:
846:
837:
822:
815:
811:
795:
772:glucose metabolic process
645:identical protein binding
595:
591:
574:
558:
549:
536:
485:
476:
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
2005:: human SDH/NAD+ complex
1311:10.2174/0929867043455927
1079:Chr 2: 122.07 – 122.1 Mb
1072:Chr 15: 45.02 – 45.08 Mb
1818:(inactive 2024-04-27).
732:response to cadmium ion
686:mitochondrial membranes
630:oxidoreductase activity
525:myocardium of ventricle
1587:10.1073/pnas.242603899
1453:J. Inherit. Metab. Dis
1435:10.1006/geno.1994.1276
1131:Sorbitol dehydrogenase
737:response to copper ion
1537:10.1007/s003359900922
706:extracellular exosome
198:Chromosome 15 (human)
640:carbohydrate binding
447:right adrenal cortex
339:2 E5|2 60.59 cM
300:Chromosome 2 (mouse)
67:List of PDB id codes
40:Available structures
1816:10.1038/nature04209
1808:2005Natur.437.1173R
1615:Acta Crystallogr. D
1578:2002PNAS...9916899M
782:response to hormone
711:extracellular space
489:seminiferous tubule
459:islet of Langerhans
455:left adrenal cortex
435:right lobe of liver
2028:This article on a
1871:10.1042/BJ20061384
1732:10.1101/gr.2596504
1465:10.1007/BF00711317
1369:10.1007/BF01951922
917:ENSMUSG00000027227
720:Biological process
664:Cellular component
603:Molecular function
505:left lobe of liver
451:left adrenal gland
2049:
2048:
2013:
2012:
1572:(26): 16899–903.
1128:
1127:
1124:
1123:
1097:
1096:
1062:
1061:
1041:
1040:
1015:
1014:
994:
993:
968:
967:
949:
948:
923:
922:
904:
903:
878:
877:
859:
858:
807:
806:
620:metal ion binding
587:
586:
583:
582:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
94:
93:
90:
89:
50:Ortholog search:
2099:
2070:
2063:
2056:
2024:
2017:
1999:
1984:
1969:
1949:
1942:
1935:
1926:
1892:
1882:
1849:
1843:
1835:
1802:(7062): 1173–8.
1790:
1753:
1743:
1710:
1700:
1675:
1638:
1621:(Pt 3): 558–60.
1609:
1599:
1589:
1556:
1519:
1509:
1484:
1446:
1417:
1388:
1351:
1322:
1283:
1282:
1275:
1269:
1268:
1236:
1230:
1229:
1218:
1212:
1211:
1200:
1194:
1184:
1173:
1163:
1110:
1109:
1081:
1074:
1057:
1045:
1036:
1024:
1020:RefSeq (protein)
1010:
998:
989:
977:
953:
934:
908:
889:
863:
844:
813:
615:zinc ion binding
593:
579:
570:
563:
556:
541:
513:seminal vesicula
481:
479:Top expressed in
474:
463:ventricular zone
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
162:SORD - orthologs
115:
108:
85:
64:
58:
37:
36:
31:
19:
2107:
2106:
2102:
2101:
2100:
2098:
2097:
2096:
2077:
2076:
2075:
2074:
2014:
2009:
2006:
2000:
1991:
1985:
1976:
1970:
1956:
1953:
1900:
1895:
1852:
1836:
1793:
1756:
1726:(10B): 2121–7.
1713:
1678:
1644:Nat. Biotechnol
1641:
1612:
1559:
1522:
1494:Eur. J. Biochem
1487:
1449:
1420:
1394:Eur. J. Biochem
1391:
1354:
1328:Eur. J. Biochem
1325:
1299:Curr. Med. Chem
1296:
1292:
1290:Further reading
1287:
1286:
1277:
1276:
1272:
1238:
1237:
1233:
1220:
1219:
1215:
1202:
1201:
1197:
1185:
1176:
1164:
1155:
1150:
1119:View/Edit Mouse
1114:View/Edit Human
1077:
1070:
1067:Location (UCSC)
1053:
1032:
1006:
985:
898:ENSG00000140263
791:
715:
676:cell projection
659:
575:
565:
564:
537:
528:
523:
519:
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
457:
453:
449:
445:
441:
437:
433:
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
73:
51:
17:
12:
11:
5:
2105:
2103:
2095:
2094:
2089:
2079:
2078:
2073:
2072:
2065:
2058:
2050:
2047:
2046:
2025:
2011:
2010:
2008:
2007:
2001:
1994:
1992:
1986:
1979:
1977:
1971:
1964:
1961:
1958:
1957:
1954:
1952:
1951:
1944:
1937:
1929:
1923:
1922:
1899:
1898:External links
1896:
1894:
1893:
1850:
1791:
1765:(1–3): 203–8.
1754:
1711:
1691:(9): 1071–85.
1676:
1656:10.1038/nbt810
1639:
1610:
1557:
1531:(12): 1042–8.
1520:
1485:
1447:
1418:
1400:(3): 1059–65.
1389:
1363:(12): 1420–2.
1352:
1323:
1293:
1291:
1288:
1285:
1284:
1270:
1231:
1213:
1195:
1174:
1152:
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1090:
1083:
1082:
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1059:
1049:
1048:
1042:
1039:
1038:
1028:
1027:
1021:
1017:
1016:
1013:
1012:
1002:
1001:
995:
992:
991:
981:
980:
974:
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969:
966:
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957:
956:
950:
947:
946:
938:
937:
931:
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905:
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901:
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886:
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856:
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789:
784:
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769:
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739:
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729:
723:
721:
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708:
703:
698:
693:
688:
683:
678:
673:
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647:
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637:
632:
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617:
612:
606:
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584:
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572:
571:
553:
547:
546:
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533:
530:
529:
527:
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522:
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510:
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502:
498:
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486:
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482:
471:
468:
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456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
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194:
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166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2104:
2093:
2090:
2088:
2085:
2084:
2082:
2071:
2066:
2064:
2059:
2057:
2052:
2051:
2045:
2043:
2039:
2035:
2034:chromosome 15
2031:
2026:
2023:
2019:
2004:
1998:
1993:
1989:
1983:
1978:
1974:
1968:
1963:
1959:
1950:
1945:
1943:
1938:
1936:
1931:
1930:
1927:
1920:
1916:
1915:
1910:
1906:
1902:
1901:
1897:
1890:
1886:
1881:
1876:
1872:
1868:
1864:
1860:
1856:
1851:
1847:
1841:
1833:
1829:
1825:
1821:
1817:
1813:
1809:
1805:
1801:
1797:
1792:
1788:
1784:
1780:
1776:
1772:
1768:
1764:
1760:
1755:
1751:
1747:
1742:
1737:
1733:
1729:
1725:
1721:
1717:
1712:
1708:
1704:
1699:
1694:
1690:
1686:
1682:
1677:
1673:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1640:
1636:
1632:
1628:
1624:
1620:
1616:
1611:
1607:
1603:
1598:
1593:
1588:
1583:
1579:
1575:
1571:
1567:
1563:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1530:
1526:
1521:
1517:
1513:
1508:
1503:
1499:
1495:
1491:
1486:
1482:
1478:
1474:
1470:
1466:
1462:
1458:
1454:
1448:
1444:
1440:
1436:
1432:
1428:
1424:
1419:
1415:
1411:
1407:
1403:
1399:
1395:
1390:
1386:
1382:
1378:
1374:
1370:
1366:
1362:
1358:
1353:
1349:
1345:
1341:
1337:
1334:(3): 543–50.
1333:
1329:
1324:
1320:
1316:
1312:
1308:
1305:(4): 465–76.
1304:
1300:
1295:
1294:
1289:
1280:
1274:
1271:
1266:
1262:
1258:
1254:
1250:
1246:
1242:
1235:
1232:
1227:
1223:
1217:
1214:
1209:
1205:
1199:
1196:
1192:
1188:
1183:
1181:
1179:
1175:
1171:
1167:
1162:
1160:
1158:
1154:
1147:
1145:
1143:
1140:
1136:
1132:
1120:
1115:
1111:
1107:
1104:
1100:
1093:
1091:
1088:
1084:
1080:
1076:
1073:
1069:
1065:
1058:
1056:
1050:
1046:
1043:
1037:
1035:
1029:
1025:
1022:
1018:
1011:
1009:
1003:
999:
996:
990:
988:
982:
978:
975:
973:RefSeq (mRNA)
971:
964:
963:
958:
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945:
944:
939:
935:
932:
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926:
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913:
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906:
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899:
894:
890:
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881:
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873:
868:
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849:
845:
842:
840:
836:
833:
830:
828:
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821:
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810:
803:
799:
794:
788:
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748:
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743:
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733:
730:
728:
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724:
722:
719:
718:
712:
709:
707:
704:
702:
701:motile cilium
699:
697:
696:mitochondrion
694:
692:
689:
687:
684:
682:
679:
677:
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672:
669:
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648:
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628:
626:
623:
621:
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613:
611:
608:
607:
605:
602:
601:
598:
597:Gene ontology
594:
590:
578:
573:
569:
562:
557:
554:
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540:
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524:
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516:
512:
508:
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389:
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371:
363:
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317:
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296:
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107:
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97:
86:
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76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2042:expanding it
2027:
2002:
1987:
1972:
1912:
1865:(3): 421–9.
1862:
1858:
1840:cite journal
1799:
1795:
1762:
1758:
1723:
1719:
1688:
1684:
1650:(5): 566–9.
1647:
1643:
1618:
1614:
1569:
1565:
1528:
1525:Mamm. Genome
1524:
1500:(3): 760–7.
1497:
1493:
1459:(1): 67–72.
1456:
1452:
1429:(2): 354–8.
1426:
1422:
1397:
1393:
1360:
1356:
1331:
1327:
1302:
1298:
1273:
1251:(1): 55–62.
1248:
1244:
1234:
1225:
1216:
1207:
1198:
1138:
1130:
1129:
1052:
1031:
1005:
984:
960:
941:
915:
896:
870:
851:
831:
826:
509:human kidney
501:spermatocyte
497:right kidney
401:
394:
360:122,095,821
347:122,065,230
121:External IDs
72:
1955:PDB gallery
1357:Experientia
610:NAD binding
259:45,077,185
246:45,023,147
99:Identifiers
2081:Categories
1859:Biochem. J
1720:Genome Res
1193:, May 2017
1172:, May 2017
1148:References
521:blastocyst
405:(ortholog)
142:HomoloGene
2032:on human
1685:Structure
1055:NP_666238
1034:NP_003095
1008:NM_146126
987:NM_003104
817:Orthologs
493:spermatid
150:GeneCards
1889:17343568
1824:16189514
1779:15862967
1750:15489334
1707:12962626
1672:23783563
1664:12665801
1635:12595725
1606:12477932
1553:21773145
1423:Genomics
1319:14965227
1245:Genomics
1189:–
1168:–
1103:Wikidata
796:Sources:
681:membrane
443:prostate
1919:PDBe-KB
1909:UniProt
1880:1896283
1832:4427026
1804:Bibcode
1787:9746088
1574:Bibcode
1545:9880675
1516:9183016
1481:6783099
1473:8487505
1443:8088829
1414:7601136
1385:2545958
1377:6439573
1348:2691249
1265:7782086
1191:Ensembl
1170:Ensembl
929:UniProt
884:Ensembl
823:Species
802:QuickGO
671:cytosol
380:pattern
238:15q21.1
106:Aliases
1914:Q00796
1887:
1877:
1830:
1822:
1796:Nature
1785:
1777:
1748:
1741:528928
1738:
1705:
1670:
1662:
1633:
1604:
1597:139241
1594:
1551:
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1514:
1479:
1471:
1441:
1412:
1383:
1375:
1346:
1317:
1263:
1135:enzyme
1133:is an
1089:search
1087:PubMed
962:Q64442
943:Q00796
839:Entrez
691:cilium
551:BioGPS
517:morula
130:182500
2036:is a
1828:S2CID
1783:S2CID
1668:S2CID
1549:S2CID
1477:S2CID
1381:S2CID
872:20322
832:Mouse
827:Human
798:Amigo
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
146:56080
138:98266
2038:stub
2030:gene
2003:1pl8
1988:1pl7
1973:1pl6
1907:for
1885:PMID
1846:link
1820:PMID
1775:PMID
1746:PMID
1703:PMID
1660:PMID
1631:PMID
1602:PMID
1541:PMID
1512:PMID
1469:PMID
1439:PMID
1410:PMID
1373:PMID
1344:PMID
1315:PMID
1261:PMID
1142:gene
1139:SORD
853:6652
386:Bgee
334:Band
295:Chr.
233:Band
192:Chr.
154:SORD
126:OMIM
113:SORD
83:1PL7
79:1PL6
75:1PL8
56:RCSB
53:PDBe
22:SORD
1905:PDB
1875:PMC
1867:doi
1863:404
1812:doi
1800:437
1767:doi
1736:PMC
1728:doi
1693:doi
1652:doi
1623:doi
1592:PMC
1582:doi
1533:doi
1502:doi
1498:245
1461:doi
1431:doi
1402:doi
1398:230
1365:doi
1336:doi
1332:186
1307:doi
1253:doi
356:End
255:End
158:OMA
134:MGI
46:PDB
2083::
1911::
1883:.
1873:.
1861:.
1857:.
1842:}}
1838:{{
1826:.
1810:.
1798:.
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1724:14
1722:.
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1689:11
1687:.
1683:.
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1658:.
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1646:.
1629:.
1619:59
1617:.
1600:.
1590:.
1580:.
1570:99
1568:.
1564:.
1547:.
1539:.
1527:.
1510:.
1496:.
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1475:.
1467:.
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1455:.
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1427:21
1425:.
1408:.
1396:.
1379:.
1371:.
1361:40
1359:.
1342:.
1330:.
1313:.
1303:11
1301:.
1259:.
1249:26
1247:.
1243:.
1224:.
1206:.
1177:^
1156:^
1144:.
800:/
362:bp
349:bp
261:bp
248:bp
156:;
152::
148:;
144::
140:;
136::
132:;
128::
81:,
77:,
2069:e
2062:t
2055:v
2044:.
1948:e
1941:t
1934:v
1921:.
1891:.
1869::
1848:)
1834:.
1814::
1806::
1789:.
1769::
1752:.
1730::
1709:.
1695::
1674:.
1654::
1637:.
1625::
1608:.
1584::
1576::
1555:.
1535::
1529:9
1518:.
1504::
1483:.
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1445:.
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1416:.
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1387:.
1367::
1350:.
1338::
1321:.
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1255::
1228:.
1210:.
280:)
177:)
160::
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