336:
313:
1448:
has been localized in a variety of tissues, but is found in greatest abundance in osseous tissue, tissues characterized by high turnover (such as intestinal epithelium), basement membranes, and certain neoplasms. Osteonectin is expressed by a wide variety of cells, including chondrocytes, fibroblasts, platelets, endothelial cells, epithelial cells, Leydig cells, Sertoli cells, luteal cells, adrenal cortical cells, and numerous neoplastic cell lines (such as SaOS-2 cells from human osteosarcoma).
210:
235:
2932:
587:
594:
342:
241:
2917:
51:
2902:
1443:
Fibroblasts, including periodontal fibroblasts, synthesize osteonectin. This protein is synthesized by macrophages at sites of wound repair and platelet degranulation, so it may play an important role in wound healing. SPARC does not support cell attachment, and like tenascin, is anti-adhesive and an
1447:
High levels of immunodetectable osteonectin are found in active osteoblasts and marrow progenitor cells, odontoblasts, periodontal ligament and gingival cells, and some chondrocytes and hypertrophic chondrocytes. Osteonectin is also detectable in osteoid, bone matrix proper, and dentin. Osteonectin
1444:
inhibitor of cell spreading. It disrupts focal adhesions in fibroblasts. It also regulates the proliferation of some cells, especially endothelial cells, mediated by its ability to bind to cytokines and growth factors. Osteonectin has also been found to decrease DNA synthesis in cultured bone.
1426:
This molecule has been implicated in several biological functions, including mineralization of bone and cartilage, inhibiting mineralization, modulation of cell proliferation, facilitation of acquisition of differentiated phenotype and promotion of cell attachment and spreading.
77:
1430:
A number of phosphoproteins and glycoproteins are found in bone. The phosphate is bound to the protein backbone through phosphorylated serine or threonine amino acid residues. The best characterized of these bone proteins is osteonectin. It binds collagen and
2431:
Maurer P, Hohenadl C, Hohenester E, Göhring W, Timpl R, Engel J (Oct 1995). "The C-terminal portion of BM-40 (SPARC/osteonectin) is an autonomously folding and crystallisable domain that binds calcium and collagen IV".
3390:
1626:
Wasi S, Otsuka K, Yao KL, Tung PS, Aubin JE, Sodek J, Termine JD (Jun 1984). "An osteonectinlike protein in porcine periodontal ligament and its synthesis by periodontal ligament fibroblasts".
2057:
Swaroop A, Hogan BL, Francke U (Jan 1988). "Molecular analysis of the cDNA for human SPARC/osteonectin/BM-40: sequence, expression, and localization of the gene to chromosome 5q31-q33".
2931:
2291:"Purification and partial characterization of small proteoglycans I and II, bone sialoproteins I and II, and osteonectin from the mineral compartment of developing human bone"
2398:"Role of N-linked glycosylation in human osteonectin. Effect of carbohydrate removal by N-glycanase and site-directed mutagenesis on structure and binding of type V collagen"
1784:
Altura BM (Jun 1975). "Pharmacological effects of alpha-methyldopa, alpha-methylnorepinephrine, and octopamine on rat arteriolar, arterial, and terminal vascular smooth".
349:
248:
2732:
1977:
Metsäranta M, Young MF, Sandberg M, Termine J, Vuorio E (Sep 1989). "Localization of osteonectin expression in human fetal skeletal tissues by in situ hybridization".
2016:"SPARC, a secreted protein associated with cellular proliferation, inhibits cell spreading in vitro and exhibits Ca+2-dependent binding to the extracellular matrix"
3375:
1661:
Young MF, Kerr JM, Ibaraki K, Heegaard AM, Robey PG (Aug 1992). "Structure, expression, and regulation of the major noncollagenous matrix proteins of bone".
2972:
1823:"The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors"
1007:
171:
988:
2500:
2359:
Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, Martin GR (Oct 1981). "Osteonectin, a bone-specific protein linking mineral to collagen".
2671:
4092:
4647:
3470:
2646:
2881:
1524:
1506:
4637:
3190:
2916:
335:
74:
4469:
1231:
2767:
1238:
312:
4509:
1411:, a function important to invading cancer cells within bone. Additional functions of osteonectin beneficial to tumor cells include
4359:
2848:
1542:
Villarreal XC, Mann KG, Long GL (Jul 1989). "Structure of human osteonectin based upon analysis of cDNA and genomic sequences".
4652:
3408:
3398:
2965:
1493:
1472:
1375:-rich glycoprotein consisting of a single polypeptide chain that can be broken into 4 domains: 1) a Ca binding domain near the
1327:
during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for
4657:
1489:
234:
209:
3158:
3129:
2493:
2088:"Osteonectin/SPARC/BM-40 in human decidua and carcinoma, tissues characterized by de novo formation of basement membrane"
1468:
151:
4606:
4085:
3740:
3549:
1435:
in separate domains, is found in relatively large amounts in immature bone, and promotes mineralization of collagen.
348:
247:
2158:"Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)"
4596:
3986:
2958:
1423:. Overexpression of osteonectin is reported in many human cancers such as breast, prostate, colon and pancreatic.
341:
240:
4559:
4519:
2901:
2874:
2615:
2252:
Jundt G, Berghäuser KH, Termine JD, Schulz A (May 1987). "Osteonectin--a differentiation marker of bone cells".
4499:
4474:
3448:
3255:
3225:
3119:
2486:
2472:
1408:
1052:
159:
3534:
1033:
4070:
2950:
4642:
4534:
4078:
3183:
3178:
3173:
3168:
3163:
2509:
2707:
2326:"Characterization of a novel serum albumin-binding glycoprotein secreted by endothelial cells in culture"
3370:
1577:
Guweidhi A, Kleeff J, Adwan H, Giese NA, Wente MN, Giese T, Büchler MW, Berger MR, Friess H (Aug 2005).
3915:
2867:
2727:
2212:
1834:
1400:
1336:
223:
138:
4539:
4464:
4351:
4328:
4292:
4264:
3881:
3698:
3353:
1210:
1185:
1181:
1155:
1130:
1126:
4489:
3961:
3403:
3333:
3323:
3195:
3151:
3006:
2989:
2802:
2689:
2384:
2277:
2187:
2002:
1809:
1727:
183:
3308:
1214:
1189:
1151:
1122:
2940:: STRUCTURE OF A NOVEL EXTRACELLULAR CA2+-BINDING MODULE IN BM-40(SLASH)SPARC(SLASH)OSTEONECTIN
2797:
2535:
4564:
4393:
3976:
3380:
3362:
2985:
2772:
2605:
2449:
2419:
2376:
2347:
2312:
2269:
2240:
2179:
2144:
2109:
2074:
2045:
1994:
1965:
1932:
1897:
1862:
1801:
1772:
1719:
1678:
1643:
1608:
1559:
1407:
interactions, and collagen binding. Osteonectin also increases the production and activity of
586:
131:
67:
4479:
4296:
4249:
3971:
3789:
3139:
2747:
2641:
2630:
2560:
2550:
2441:
2409:
2368:
2337:
2302:
2261:
2230:
2220:
2169:
2134:
2099:
2066:
2035:
2027:
1986:
1957:
1922:
1887:
1852:
1842:
1793:
1762:
1709:
1670:
1635:
1598:
1590:
1551:
1388:
1383:(domain I), 2) a cysteine-rich domain (II), 3) a hydrophilic region (domain III), and 4) an
1332:
1331:
in addition to bone mineral calcium. A correlation between osteonectin over-expression and
428:
359:
303:
258:
3843:
3084:
2737:
1876:"Distribution of osteonectin mRNA and protein during human embryonic and fetal development"
593:
179:
4436:
4408:
4324:
4054:
3217:
3111:
3049:
2555:
2121:
Clezardin P, Malaval L, Ehrensperger AS, Delmas PD, Dechavanne M, McGregor JL (Aug 1988).
403:
2216:
1838:
4586:
4105:
4026:
3124:
2981:
2817:
2812:
2752:
2694:
2624:
2580:
2575:
2468:
2139:
2122:
2104:
2087:
2040:
2015:
1911:"Human platelet osteonectin: release, surface expression, and partial characterization"
1603:
1594:
1578:
1432:
1420:
1380:
50:
2342:
2325:
2307:
2290:
2235:
2201:"Human platelets contain and secrete osteonectin, a major protein of mineralized bone"
2200:
922:
917:
912:
907:
902:
897:
892:
887:
882:
877:
872:
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
660:
655:
650:
645:
640:
635:
4631:
4591:
4579:
4259:
4044:
3603:
3593:
3519:
3144:
3134:
2997:
2570:
2372:
2174:
2157:
2070:
1857:
1822:
1674:
1404:
1376:
622:
2281:
2191:
2006:
1813:
1731:
4504:
4416:
4283:
4113:
4109:
3956:
3706:
3665:
3598:
2843:
2757:
2540:
2388:
1412:
1316:
421:
200:
1927:
1910:
163:
187:
4616:
4611:
4601:
4574:
4529:
4398:
4254:
4244:
4121:
4011:
3991:
3588:
3571:
3566:
3338:
3328:
3029:
3019:
2807:
2792:
2722:
2717:
2620:
2600:
2530:
1529:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1511:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1416:
35:
31:
2205:
Proceedings of the
National Academy of Sciences of the United States of America
1827:
Proceedings of the
National Academy of Sciences of the United States of America
1767:
1750:
1714:
1697:
504:
4444:
4059:
3876:
3675:
3539:
3524:
3487:
3318:
3303:
3298:
3293:
3288:
3283:
3278:
3273:
2742:
2651:
2545:
1961:
1324:
320:
217:
167:
2414:
2397:
4554:
4549:
4524:
4514:
4426:
4034:
3906:
3891:
3886:
3576:
3544:
3482:
2777:
2610:
2225:
1797:
952:
564:
442:
387:
374:
286:
273:
175:
17:
2445:
1944:
Young MF, Day AA, Dominquez P, McQuillan CI, Fisher LW, Termine JD (1990).
1847:
1776:
1612:
2453:
2423:
2380:
2351:
2316:
2273:
2244:
2183:
2148:
2113:
2078:
2049:
2031:
1998:
1969:
1936:
1901:
1866:
1805:
1723:
1682:
1647:
1563:
1278:
1273:
4373:
4368:
4363:
4341:
4336:
4314:
4309:
4269:
4039:
3800:
3711:
3529:
3474:
3014:
2762:
2517:
1892:
1875:
1751:"SPARC, a matricellular glycoprotein with important biological functions"
1698:"The biology of SPARC, a protein that modulates cell-matrix interactions"
1372:
1348:
1328:
1262:
1097:
1078:
1555:
4421:
4304:
4101:
4049:
4003:
3924:
3808:
3721:
3458:
3313:
3265:
2822:
2787:
2712:
2681:
2661:
2265:
2156:
Lankat-Buttgereit B, Mann K, Deutzmann R, Timpl R, Krieg T (Aug 1988).
1990:
1579:"Osteonectin influences growth and invasion of pancreatic cancer cells"
1384:
1302:
1064:
1019:
108:
104:
100:
96:
4494:
4213:
4173:
3858:
3828:
3770:
3765:
3760:
3755:
3750:
3732:
3559:
3554:
3512:
3507:
3453:
3441:
3436:
3431:
3235:
3230:
2782:
2595:
2590:
2585:
2565:
2525:
2086:
Wewer UM, Albrechtsen R, Fisher LW, Young MF, Termine JD (Aug 1988).
1356:
1246:
974:
1945:
1639:
4388:
4383:
4228:
4223:
4218:
4208:
4203:
4198:
4178:
4163:
4158:
4143:
4130:
3949:
3944:
3939:
3934:
3929:
3853:
3848:
3838:
3833:
3823:
3818:
3813:
3782:
3777:
3745:
3716:
3685:
3680:
3670:
3658:
3653:
3648:
3581:
3502:
3497:
3492:
3426:
3099:
3094:
3089:
3079:
3074:
3069:
3064:
2827:
2666:
2478:
1821:
Raines EW, Lane TF, Iruela-Arispe ML, Ross R, Sage EH (Feb 1992).
937:
933:
142:, BM-40, ON, OI17, secreted protein acidic and cysteine rich, ONT
4569:
4484:
4378:
4193:
4188:
4183:
4168:
4153:
4148:
4138:
3981:
3643:
3638:
3633:
3628:
3623:
3618:
3613:
3608:
3247:
3205:
3200:
3059:
3054:
3044:
3039:
3034:
3024:
2656:
1352:
1320:
1309:
155:
4074:
2954:
2863:
2482:
602:
2859:
2014:
Sage H, Vernon RB, Funk SE, Everitt EA, Angello J (Jul 1989).
1946:"Structure and expression of osteonectin mRNA in human tissue"
1368:
1403:
glycoprotein that plays a vital role in bone mineralization,
2123:"Complex formation of human thrombospondin with osteonectin"
2289:
Fisher LW, Hawkins GR, Tuross N, Termine JD (Jul 1987).
411:
1874:
Mundlos S, Schwahn B, Reichert T, Zabel B (Feb 1992).
843:
negative regulation of endothelial cell proliferation
576:
2925:: HELIX C DELETION MUTANT OF BM-40 FS-EC DOMAIN PAIR
2199:
Stenner DD, Tracy RP, Riggs BL, Mann KG (Sep 1986).
4457:
4435:
4407:
4350:
4323:
4291:
4282:
4237:
4129:
4120:
4024:
4002:
3914:
3904:
3869:
3798:
3730:
3696:
3469:
3419:
3389:
3361:
3351:
3264:
3246:
3216:
3110:
3005:
2996:
2836:
2680:
2516:
1203:
1174:
1144:
1115:
1485:
1483:
1481:
1464:
1462:
1460:
1628:Canadian Journal of Biochemistry and Cell Biology
848:positive regulation of endothelial cell migration
358:
257:
2733:Cartilage-Derived Angiogenesis Inhibitory Factor
1880:The Journal of Histochemistry and Cytochemistry
1755:The Journal of Histochemistry and Cytochemistry
1490:GRCm38: Ensembl release 89: ENSMUSG00000018593
4086:
2966:
2875:
2494:
8:
1295:secreted protein acidic and rich in cysteine
2324:Sage H, Johnson C, Bornstein P (Mar 1984).
1469:GRCh38: Ensembl release 89: ENSG00000113140
878:regulation of cell population proliferation
803:cellular response to growth factor stimulus
661:extracellular matrix structural constituent
4288:
4126:
4093:
4079:
4071:
3911:
3358:
3002:
2973:
2959:
2951:
2882:
2868:
2860:
2501:
2487:
2479:
1663:Clinical Orthopaedics and Related Research
948:
618:
399:
298:
195:
85:
2471:at the U.S. National Library of Medicine
2413:
2341:
2306:
2234:
2224:
2173:
2138:
2103:
2039:
1926:
1891:
1856:
1846:
1766:
1713:
1602:
762:collagen-containing extracellular matrix
4399:Structural maintenance of chromosomes 3
2897:
1456:
1359:and is located on chromosome 5q31-q33.
27:Mammalian protein found in Homo sapiens
1323:that binds calcium. It is secreted by
40:
363:
324:
319:
262:
221:
216:
7:
2768:matrix metalloproteinase inhibitors
2402:The Journal of Biological Chemistry
2330:The Journal of Biological Chemistry
2295:The Journal of Biological Chemistry
883:negative regulation of angiogenesis
2140:10.1111/j.1432-1033.1988.tb14194.x
1595:10.1097/01.sla.0000171866.45848.68
1200:
1171:
1141:
1112:
1088:
1069:
1043:
1024:
998:
979:
923:regulation of synapse organization
702:intracellular anatomical structure
581:
499:
437:
416:
25:
4510:Cholesterylester transfer protein
4360:Chondroitin sulfate proteoglycans
2092:The American Journal of Pathology
1305:that in humans is encoded by the
818:extracellular matrix organization
2930:
2915:
2900:
2127:European Journal of Biochemistry
1675:10.1097/00003086-199208000-00042
893:regulation of cell morphogenesis
592:
585:
347:
340:
334:
311:
246:
239:
233:
208:
49:
3409:Calcium-induced calcium release
717:platelet alpha granule membrane
3130:Ionotropic glutamate receptors
1979:Calcified Tissue International
868:response to lipopolysaccharide
603:More reference expression data
565:More reference expression data
1:
4648:Extracellular matrix proteins
2343:10.1016/S0021-9258(17)43194-2
2308:10.1016/S0021-9258(18)47991-4
1928:10.1182/blood.V75.5.1105.1105
1909:Kelm RJ, Mann KG (Mar 1990).
1696:Lane TF, Sage EH (Feb 1994).
1347:The human SPARC gene is 26.5
838:receptor-mediated endocytosis
332:
231:
3982:Dentin matrix phosphoprotein
2434:Journal of Molecular Biology
2396:Xie RL, Long GL (Sep 1995).
2373:10.1016/0092-8674(81)90037-4
2175:10.1016/0014-5793(88)80054-1
2071:10.1016/0888-7543(88)90107-3
1299:basement-membrane protein 40
727:platelet alpha granule lumen
651:extracellular matrix binding
4638:Genes on human chromosome 5
4607:Tumor necrosis factor alpha
2020:The Journal of Cell Biology
1749:Yan Q, Sage EH (Dec 1999).
823:response to L-ascorbic acid
808:response to peptide hormone
457:stromal cell of endometrium
4674:
4597:Thyroxine-binding proteins
3987:Dentin sialophosphoprotein
2910:: BM-40, FS/EC DOMAIN PAIR
2616:proliferin-related protein
1950:Connective Tissue Research
1768:10.1177/002215549904701201
1715:10.1096/fasebj.8.2.8119487
828:response to glucocorticoid
29:
4560:Serum amyloid P component
4520:Colony-stimulating factor
3449:Sodium-calcium exchangers
3226:Sodium-calcium exchangers
2895:
1962:10.3109/03008209009152419
1525:"Mouse PubMed Reference:"
1507:"Human PubMed Reference:"
1409:matrix metalloproteinases
1399:Osteonectin is an acidic
1277:
1272:
1268:
1261:
1245:
1232:Chr 5: 151.66 – 151.69 Mb
1226:
1207:
1178:
1167:
1148:
1119:
1108:
1095:
1091:
1076:
1072:
1063:
1050:
1046:
1031:
1027:
1018:
1005:
1001:
986:
982:
973:
958:
951:
947:
931:
621:
617:
600:
584:
575:
562:
511:
502:
485:Descending thoracic aorta
449:
440:
410:
402:
398:
381:
368:
331:
310:
301:
297:
280:
267:
230:
207:
198:
194:
149:
146:
136:
129:
124:
93:
88:
71:
66:
61:
57:
48:
43:
4500:B-cell activating factor
4475:Alpha 1-antichymotrypsin
3535:Neuronal calcium sensors
3256:Calcium-sensing receptor
2473:Medical Subject Headings
2415:10.1074/jbc.270.39.23212
2254:Cell and Tissue Research
1239:Chr 11: 55.29 – 55.31 Mb
365:11 B1.3|11 33.04 cM
30:Not to be confused with
2849:Angiogenesis inhibitors
2226:10.1073/pnas.83.18.6892
1798:10.1161/01.res.36.6.233
853:response to calcium ion
788:response to cadmium ion
687:endocytic vesicle lumen
4653:Matricellular proteins
4535:Membrane glycoproteins
3391:Intracellular channels
2446:10.1006/jmbi.1995.0557
1848:10.1073/pnas.89.4.1281
1351:long, and contains 10
813:platelet degranulation
682:platelet alpha granule
4658:Genes mutated in mice
2032:10.1083/jcb.109.1.341
1792:(6 Suppl 1): 233–40.
888:inner ear development
767:glutamatergic synapse
539:stroma of bone marrow
326:Chromosome 11 (mouse)
3916:Extracellular matrix
2728:carboxyamidotriazole
2708:angiostatic steroids
1893:10.1177/40.2.1552170
1786:Circulation Research
1401:extracellular matrix
1391:region (domain IV).
1379:-rich region at the
1367:Osteonectin is a 40
1337:chronic pancreatitis
873:response to lead ion
783:response to cytokine
752:extracellular matrix
747:extracellular region
489:smooth muscle tissue
224:Chromosome 5 (human)
89:List of PDB id codes
62:Available structures
4540:Myelin protein zero
4465:Activin and inhibin
4265:Phytohaemagglutinin
3882:Parathyroid hormone
3870:Indirect regulators
3420:Intracellular pumps
2217:1986PNAS...83.6892S
1839:1992PNAS...89.1281R
1556:10.1021/bi00441a049
1439:Tissue distribution
1293:(ON) also known as
913:signal transduction
903:response to ethanol
858:response to gravity
737:extracellular space
636:calcium ion binding
469:trigeminal ganglion
4490:Asialoglycoprotein
3962:Matrix gla protein
3799:Calcium-dependent
3731:Calcium-dependent
3697:Calcium-dependent
3404:Ryanodine receptor
3007:Adhesion molecules
2990:calcium metabolism
2803:tetrathiomolybdate
2690:2-Methoxyestradiol
2367:(1 Pt 1): 99–105.
2266:10.1007/bf00218209
1991:10.1007/BF02556057
1053:ENSMUSG00000018593
776:Biological process
670:Cellular component
629:Molecular function
531:tibiofemoral joint
4625:
4624:
4565:Sialoglycoprotein
4453:
4452:
4394:Platelet factor 4
4278:
4277:
4068:
4067:
4020:
4019:
4004:Secreted hormones
3977:Bone sialoprotein
3900:
3899:
3363:Second messengers
3347:
3346:
3140:Kainate receptors
2986:calcium signaling
2948:
2947:
2857:
2856:
2828:VEGFR antagonists
2773:platelet factor-4
2606:platelet factor-4
1583:Annals of Surgery
1333:ampullary cancers
1315:Osteonectin is a
1288:
1287:
1284:
1283:
1257:
1256:
1222:
1221:
1197:
1196:
1163:
1162:
1138:
1137:
1104:
1103:
1085:
1084:
1059:
1058:
1040:
1039:
1014:
1013:
995:
994:
943:
942:
863:heart development
707:basement membrane
641:metal ion binding
613:
612:
609:
608:
571:
570:
558:
557:
496:
495:
461:periodontal fiber
394:
393:
293:
292:
188:SPARC - orthologs
120:
119:
116:
115:
72:Ortholog search:
16:(Redirected from
4665:
4480:Apolipoprotein H
4289:
4250:Intrinsic factor
4127:
4095:
4088:
4081:
4072:
4025:Calcium-binding
3912:
3790:Protein kinase C
3359:
3112:Calcium channels
3003:
2975:
2968:
2961:
2952:
2934:
2919:
2904:
2884:
2877:
2870:
2861:
2642:Thrombospondin 1
2631:antithrombin III
2503:
2496:
2489:
2480:
2457:
2427:
2417:
2392:
2355:
2345:
2336:(6): 3993–4007.
2320:
2310:
2285:
2248:
2238:
2228:
2195:
2177:
2152:
2142:
2117:
2107:
2082:
2053:
2043:
2010:
1973:
1940:
1930:
1905:
1895:
1870:
1860:
1850:
1817:
1780:
1770:
1761:(12): 1495–506.
1736:
1735:
1717:
1693:
1687:
1686:
1658:
1652:
1651:
1623:
1617:
1616:
1606:
1574:
1568:
1567:
1539:
1533:
1532:
1521:
1515:
1514:
1503:
1497:
1487:
1476:
1466:
1389:carboxy terminus
1339:has been found.
1270:
1269:
1241:
1234:
1217:
1201:
1192:
1172:
1168:RefSeq (protein)
1158:
1142:
1133:
1113:
1089:
1070:
1044:
1025:
999:
980:
949:
908:bone development
898:response to cAMP
798:lung development
656:collagen binding
619:
605:
596:
589:
582:
567:
543:efferent ductule
507:
505:Top expressed in
500:
445:
443:Top expressed in
438:
417:
400:
390:
377:
366:
351:
344:
338:
327:
315:
299:
289:
276:
265:
250:
243:
237:
226:
212:
196:
190:
141:
134:
111:
86:
80:
59:
58:
53:
41:
21:
4673:
4672:
4668:
4667:
4666:
4664:
4663:
4662:
4628:
4627:
4626:
4621:
4449:
4431:
4403:
4346:
4319:
4274:
4233:
4116:
4099:
4069:
4064:
4055:EGF-like domain
4016:
3998:
3896:
3865:
3794:
3726:
3692:
3465:
3415:
3385:
3343:
3260:
3242:
3212:
3106:
2992:
2979:
2949:
2944:
2941:
2935:
2926:
2920:
2911:
2905:
2891:
2888:
2858:
2853:
2832:
2702:
2698:
2676:
2662:soluble VEGFR-1
2512:
2510:Antiangiogenics
2507:
2465:
2460:
2430:
2408:(39): 23212–7.
2395:
2358:
2323:
2288:
2251:
2198:
2155:
2120:
2085:
2056:
2013:
1976:
1943:
1908:
1873:
1820:
1783:
1748:
1744:
1742:Further reading
1739:
1695:
1694:
1690:
1669:(281): 275–94.
1660:
1659:
1655:
1640:10.1139/o84-064
1625:
1624:
1620:
1576:
1575:
1571:
1550:(15): 6483–91.
1541:
1540:
1536:
1523:
1522:
1518:
1505:
1504:
1500:
1488:
1479:
1467:
1458:
1454:
1441:
1397:
1365:
1345:
1279:View/Edit Mouse
1274:View/Edit Human
1237:
1230:
1227:Location (UCSC)
1213:
1209:
1188:
1184:
1180:
1154:
1150:
1129:
1125:
1121:
1034:ENSG00000113140
927:
771:
697:plasma membrane
665:
646:protein binding
601:
591:
590:
563:
554:
549:
545:
541:
537:
533:
529:
525:
523:ascending aorta
521:
517:
503:
492:
487:
483:
481:visceral pleura
479:
475:
471:
467:
463:
459:
455:
441:
385:
372:
364:
354:
353:
352:
345:
325:
302:Gene location (
284:
271:
263:
253:
252:
251:
244:
222:
199:Gene location (
150:
137:
130:
95:
73:
39:
28:
23:
22:
15:
12:
11:
5:
4671:
4669:
4661:
4660:
4655:
4650:
4645:
4640:
4630:
4629:
4623:
4622:
4620:
4619:
4614:
4609:
4604:
4599:
4594:
4589:
4587:Thrombopoietin
4584:
4583:
4582:
4577:
4572:
4562:
4557:
4552:
4547:
4542:
4537:
4532:
4527:
4522:
4517:
4512:
4507:
4502:
4497:
4492:
4487:
4482:
4477:
4472:
4467:
4461:
4459:
4455:
4454:
4451:
4450:
4448:
4447:
4441:
4439:
4433:
4432:
4430:
4429:
4424:
4419:
4413:
4411:
4405:
4404:
4402:
4401:
4396:
4391:
4386:
4381:
4376:
4371:
4366:
4356:
4354:
4348:
4347:
4345:
4344:
4339:
4333:
4331:
4321:
4320:
4318:
4317:
4312:
4307:
4301:
4299:
4286:
4280:
4279:
4276:
4275:
4273:
4272:
4267:
4262:
4257:
4252:
4247:
4241:
4239:
4235:
4234:
4232:
4231:
4226:
4221:
4216:
4211:
4206:
4201:
4196:
4191:
4186:
4181:
4176:
4171:
4166:
4161:
4156:
4151:
4146:
4141:
4135:
4133:
4124:
4118:
4117:
4106:glycoconjugate
4100:
4098:
4097:
4090:
4083:
4075:
4066:
4065:
4063:
4062:
4057:
4052:
4047:
4042:
4037:
4031:
4029:
4022:
4021:
4018:
4017:
4015:
4014:
4008:
4006:
4000:
3999:
3997:
3996:
3995:
3994:
3989:
3984:
3979:
3969:
3964:
3959:
3954:
3953:
3952:
3947:
3942:
3937:
3932:
3921:
3919:
3909:
3905:Extracellular
3902:
3901:
3898:
3897:
3895:
3894:
3889:
3884:
3879:
3873:
3871:
3867:
3866:
3864:
3863:
3862:
3861:
3856:
3851:
3846:
3841:
3836:
3831:
3826:
3821:
3816:
3805:
3803:
3796:
3795:
3793:
3792:
3787:
3786:
3785:
3780:
3775:
3774:
3773:
3768:
3763:
3758:
3748:
3737:
3735:
3728:
3727:
3725:
3724:
3719:
3714:
3709:
3703:
3701:
3694:
3693:
3691:
3690:
3689:
3688:
3683:
3673:
3668:
3663:
3662:
3661:
3656:
3651:
3646:
3641:
3636:
3631:
3626:
3621:
3616:
3611:
3604:Synaptotagmins
3601:
3596:
3591:
3586:
3585:
3584:
3579:
3574:
3569:
3564:
3563:
3562:
3557:
3547:
3542:
3532:
3527:
3522:
3517:
3516:
3515:
3510:
3505:
3500:
3495:
3485:
3479:
3477:
3467:
3466:
3464:
3463:
3462:
3461:
3456:
3446:
3445:
3444:
3439:
3434:
3423:
3421:
3417:
3416:
3414:
3413:
3412:
3411:
3401:
3395:
3393:
3387:
3386:
3384:
3383:
3378:
3373:
3367:
3365:
3356:
3352:Intracellular
3349:
3348:
3345:
3344:
3342:
3341:
3336:
3331:
3326:
3321:
3316:
3311:
3306:
3301:
3296:
3291:
3286:
3281:
3276:
3270:
3268:
3262:
3261:
3259:
3258:
3252:
3250:
3244:
3243:
3241:
3240:
3239:
3238:
3233:
3222:
3220:
3214:
3213:
3211:
3210:
3209:
3208:
3203:
3198:
3188:
3187:
3186:
3181:
3176:
3171:
3166:
3156:
3155:
3154:
3149:
3148:
3147:
3145:NMDA receptors
3142:
3137:
3135:AMPA receptors
3127:
3125:5-HT3 receptor
3116:
3114:
3108:
3107:
3105:
3104:
3103:
3102:
3097:
3092:
3087:
3082:
3077:
3072:
3067:
3062:
3057:
3052:
3047:
3042:
3037:
3032:
3027:
3022:
3011:
3009:
3000:
2994:
2993:
2982:Cell signaling
2980:
2978:
2977:
2970:
2963:
2955:
2946:
2945:
2943:
2942:
2936:
2929:
2927:
2921:
2914:
2912:
2906:
2899:
2896:
2893:
2892:
2889:
2887:
2886:
2879:
2872:
2864:
2855:
2854:
2852:
2851:
2846:
2840:
2838:
2834:
2833:
2831:
2830:
2825:
2820:
2818:thrombospondin
2815:
2813:thrombospondin
2810:
2805:
2800:
2795:
2790:
2785:
2780:
2775:
2770:
2765:
2760:
2755:
2750:
2745:
2740:
2735:
2730:
2725:
2720:
2715:
2710:
2705:
2700:
2696:
2692:
2686:
2684:
2678:
2677:
2675:
2674:
2669:
2664:
2659:
2654:
2649:
2644:
2639:
2634:
2628:
2625:kringle domain
2618:
2613:
2608:
2603:
2598:
2593:
2588:
2583:
2578:
2573:
2568:
2563:
2558:
2553:
2548:
2543:
2538:
2533:
2528:
2526:Angiopoietin 2
2522:
2520:
2514:
2513:
2508:
2506:
2505:
2498:
2491:
2483:
2477:
2476:
2464:
2463:External links
2461:
2459:
2458:
2428:
2393:
2356:
2321:
2301:(20): 9702–8.
2286:
2249:
2211:(18): 6892–6.
2196:
2153:
2118:
2083:
2054:
2011:
1974:
1941:
1921:(5): 1105–13.
1906:
1871:
1818:
1781:
1745:
1743:
1740:
1738:
1737:
1688:
1653:
1618:
1569:
1534:
1516:
1498:
1477:
1455:
1453:
1450:
1440:
1437:
1433:hydroxyapatite
1396:
1393:
1381:amino terminus
1364:
1361:
1344:
1341:
1286:
1285:
1282:
1281:
1276:
1266:
1265:
1259:
1258:
1255:
1254:
1252:
1250:
1243:
1242:
1235:
1228:
1224:
1223:
1220:
1219:
1205:
1204:
1198:
1195:
1194:
1176:
1175:
1169:
1165:
1164:
1161:
1160:
1146:
1145:
1139:
1136:
1135:
1117:
1116:
1110:
1106:
1105:
1102:
1101:
1093:
1092:
1086:
1083:
1082:
1074:
1073:
1067:
1061:
1060:
1057:
1056:
1048:
1047:
1041:
1038:
1037:
1029:
1028:
1022:
1016:
1015:
1012:
1011:
1003:
1002:
996:
993:
992:
984:
983:
977:
971:
970:
965:
960:
956:
955:
945:
944:
941:
940:
929:
928:
926:
925:
920:
915:
910:
905:
900:
895:
890:
885:
880:
875:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
779:
777:
773:
772:
770:
769:
764:
759:
754:
749:
744:
739:
734:
729:
724:
719:
714:
709:
704:
699:
694:
692:nuclear matrix
689:
684:
679:
673:
671:
667:
666:
664:
663:
658:
653:
648:
643:
638:
632:
630:
626:
625:
615:
614:
611:
610:
607:
606:
598:
597:
579:
573:
572:
569:
568:
560:
559:
556:
555:
553:
552:
548:
544:
540:
536:
532:
528:
524:
520:
516:
512:
509:
508:
497:
494:
493:
491:
490:
486:
482:
478:
477:spinal ganglia
474:
473:olfactory bulb
470:
466:
462:
458:
454:
450:
447:
446:
434:
433:
425:
414:
408:
407:
404:RNA expression
396:
395:
392:
391:
383:
379:
378:
370:
367:
362:
356:
355:
346:
339:
333:
329:
328:
323:
317:
316:
308:
307:
295:
294:
291:
290:
282:
278:
277:
269:
266:
261:
255:
254:
245:
238:
232:
228:
227:
220:
214:
213:
205:
204:
192:
191:
148:
144:
143:
135:
127:
126:
122:
121:
118:
117:
114:
113:
91:
90:
82:
81:
70:
64:
63:
55:
54:
46:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4670:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4643:Glycoproteins
4641:
4639:
4636:
4635:
4633:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4592:Thyroglobulin
4590:
4588:
4585:
4581:
4580:Glycophorin C
4578:
4576:
4573:
4571:
4568:
4567:
4566:
4563:
4561:
4558:
4556:
4553:
4551:
4548:
4546:
4543:
4541:
4538:
4536:
4533:
4531:
4528:
4526:
4523:
4521:
4518:
4516:
4513:
4511:
4508:
4506:
4503:
4501:
4498:
4496:
4493:
4491:
4488:
4486:
4483:
4481:
4478:
4476:
4473:
4471:
4468:
4466:
4463:
4462:
4460:
4456:
4446:
4443:
4442:
4440:
4438:
4434:
4428:
4425:
4423:
4420:
4418:
4415:
4414:
4412:
4410:
4406:
4400:
4397:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4361:
4358:
4357:
4355:
4353:
4349:
4343:
4340:
4338:
4335:
4334:
4332:
4330:
4326:
4322:
4316:
4313:
4311:
4308:
4306:
4303:
4302:
4300:
4298:
4294:
4290:
4287:
4285:
4284:Proteoglycans
4281:
4271:
4268:
4266:
4263:
4261:
4260:Peptidoglycan
4258:
4256:
4253:
4251:
4248:
4246:
4243:
4242:
4240:
4236:
4230:
4227:
4225:
4222:
4220:
4217:
4215:
4212:
4210:
4207:
4205:
4202:
4200:
4197:
4195:
4192:
4190:
4187:
4185:
4182:
4180:
4177:
4175:
4172:
4170:
4167:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4142:
4140:
4137:
4136:
4134:
4132:
4128:
4125:
4123:
4119:
4115:
4114:glycopeptides
4111:
4110:glycoproteins
4107:
4103:
4096:
4091:
4089:
4084:
4082:
4077:
4076:
4073:
4061:
4058:
4056:
4053:
4051:
4048:
4046:
4045:C-type lectin
4043:
4041:
4038:
4036:
4033:
4032:
4030:
4028:
4023:
4013:
4010:
4009:
4007:
4005:
4001:
3993:
3990:
3988:
3985:
3983:
3980:
3978:
3975:
3974:
3973:
3970:
3968:
3965:
3963:
3960:
3958:
3955:
3951:
3948:
3946:
3943:
3941:
3938:
3936:
3933:
3931:
3928:
3927:
3926:
3923:
3922:
3920:
3917:
3913:
3910:
3908:
3903:
3893:
3890:
3888:
3885:
3883:
3880:
3878:
3875:
3874:
3872:
3868:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3830:
3827:
3825:
3822:
3820:
3817:
3815:
3812:
3811:
3810:
3807:
3806:
3804:
3802:
3797:
3791:
3788:
3784:
3781:
3779:
3776:
3772:
3769:
3767:
3764:
3762:
3759:
3757:
3754:
3753:
3752:
3749:
3747:
3744:
3743:
3742:
3739:
3738:
3736:
3734:
3729:
3723:
3720:
3718:
3715:
3713:
3710:
3708:
3705:
3704:
3702:
3700:
3695:
3687:
3684:
3682:
3679:
3678:
3677:
3674:
3672:
3669:
3667:
3664:
3660:
3657:
3655:
3652:
3650:
3647:
3645:
3642:
3640:
3637:
3635:
3632:
3630:
3627:
3625:
3622:
3620:
3617:
3615:
3612:
3610:
3607:
3606:
3605:
3602:
3600:
3597:
3595:
3594:Phospholamban
3592:
3590:
3587:
3583:
3580:
3578:
3575:
3573:
3570:
3568:
3565:
3561:
3558:
3556:
3553:
3552:
3551:
3548:
3546:
3543:
3541:
3538:
3537:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3520:Calsequestrin
3518:
3514:
3511:
3509:
3506:
3504:
3501:
3499:
3496:
3494:
3491:
3490:
3489:
3486:
3484:
3481:
3480:
3478:
3476:
3472:
3468:
3460:
3457:
3455:
3452:
3451:
3450:
3447:
3443:
3440:
3438:
3435:
3433:
3430:
3429:
3428:
3425:
3424:
3422:
3418:
3410:
3407:
3406:
3405:
3402:
3400:
3397:
3396:
3394:
3392:
3388:
3382:
3379:
3377:
3374:
3372:
3369:
3368:
3366:
3364:
3360:
3357:
3355:
3350:
3340:
3337:
3335:
3332:
3330:
3327:
3325:
3322:
3320:
3317:
3315:
3312:
3310:
3307:
3305:
3302:
3300:
3297:
3295:
3292:
3290:
3287:
3285:
3282:
3280:
3277:
3275:
3272:
3271:
3269:
3267:
3263:
3257:
3254:
3253:
3251:
3249:
3245:
3237:
3234:
3232:
3229:
3228:
3227:
3224:
3223:
3221:
3219:
3218:Calcium pumps
3215:
3207:
3204:
3202:
3199:
3197:
3194:
3193:
3192:
3189:
3185:
3182:
3180:
3177:
3175:
3172:
3170:
3167:
3165:
3162:
3161:
3160:
3159:Voltage-gated
3157:
3153:
3152:P2X receptors
3150:
3146:
3143:
3141:
3138:
3136:
3133:
3132:
3131:
3128:
3126:
3123:
3122:
3121:
3118:
3117:
3115:
3113:
3109:
3101:
3098:
3096:
3093:
3091:
3088:
3086:
3083:
3081:
3078:
3076:
3073:
3071:
3068:
3066:
3063:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3041:
3038:
3036:
3033:
3031:
3028:
3026:
3023:
3021:
3018:
3017:
3016:
3013:
3012:
3010:
3008:
3004:
3001:
2999:
2998:Cell membrane
2995:
2991:
2987:
2983:
2976:
2971:
2969:
2964:
2962:
2957:
2956:
2953:
2939:
2933:
2928:
2924:
2918:
2913:
2909:
2903:
2898:
2894:
2885:
2880:
2878:
2873:
2871:
2866:
2865:
2862:
2850:
2847:
2845:
2842:
2841:
2839:
2835:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2794:
2791:
2789:
2786:
2784:
2781:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2749:
2746:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2714:
2711:
2709:
2706:
2704:
2693:
2691:
2688:
2687:
2685:
2683:
2679:
2673:
2670:
2668:
2665:
2663:
2660:
2658:
2655:
2653:
2650:
2648:
2645:
2643:
2640:
2638:
2635:
2632:
2629:
2626:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2602:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2582:
2579:
2577:
2574:
2572:
2569:
2567:
2564:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2537:
2534:
2532:
2529:
2527:
2524:
2523:
2521:
2519:
2515:
2511:
2504:
2499:
2497:
2492:
2490:
2485:
2484:
2481:
2474:
2470:
2467:
2466:
2462:
2455:
2451:
2447:
2443:
2440:(2): 347–57.
2439:
2435:
2429:
2425:
2421:
2416:
2411:
2407:
2403:
2399:
2394:
2390:
2386:
2382:
2378:
2374:
2370:
2366:
2362:
2357:
2353:
2349:
2344:
2339:
2335:
2331:
2327:
2322:
2318:
2314:
2309:
2304:
2300:
2296:
2292:
2287:
2283:
2279:
2275:
2271:
2267:
2263:
2260:(2): 409–15.
2259:
2255:
2250:
2246:
2242:
2237:
2232:
2227:
2222:
2218:
2214:
2210:
2206:
2202:
2197:
2193:
2189:
2185:
2181:
2176:
2171:
2167:
2163:
2159:
2154:
2150:
2146:
2141:
2136:
2133:(2): 275–84.
2132:
2128:
2124:
2119:
2115:
2111:
2106:
2101:
2098:(2): 345–55.
2097:
2093:
2089:
2084:
2080:
2076:
2072:
2068:
2064:
2060:
2055:
2051:
2047:
2042:
2037:
2033:
2029:
2026:(1): 341–56.
2025:
2021:
2017:
2012:
2008:
2004:
2000:
1996:
1992:
1988:
1985:(3): 146–52.
1984:
1980:
1975:
1971:
1967:
1963:
1959:
1955:
1951:
1947:
1942:
1938:
1934:
1929:
1924:
1920:
1916:
1912:
1907:
1903:
1899:
1894:
1889:
1886:(2): 283–91.
1885:
1881:
1877:
1872:
1868:
1864:
1859:
1854:
1849:
1844:
1840:
1836:
1833:(4): 1281–5.
1832:
1828:
1824:
1819:
1815:
1811:
1807:
1803:
1799:
1795:
1791:
1787:
1782:
1778:
1774:
1769:
1764:
1760:
1756:
1752:
1747:
1746:
1741:
1733:
1729:
1725:
1721:
1716:
1711:
1708:(2): 163–73.
1707:
1703:
1702:FASEB Journal
1699:
1692:
1689:
1684:
1680:
1676:
1672:
1668:
1664:
1657:
1654:
1649:
1645:
1641:
1637:
1633:
1629:
1622:
1619:
1614:
1610:
1605:
1600:
1596:
1592:
1589:(2): 224–34.
1588:
1584:
1580:
1573:
1570:
1565:
1561:
1557:
1553:
1549:
1545:
1538:
1535:
1530:
1526:
1520:
1517:
1512:
1508:
1502:
1499:
1495:
1491:
1486:
1484:
1482:
1478:
1474:
1470:
1465:
1463:
1461:
1457:
1451:
1449:
1445:
1438:
1436:
1434:
1428:
1424:
1422:
1418:
1417:proliferation
1414:
1410:
1406:
1402:
1394:
1392:
1390:
1387:motif at the
1386:
1382:
1378:
1377:glutamic acid
1374:
1370:
1362:
1360:
1358:
1354:
1350:
1342:
1340:
1338:
1334:
1330:
1326:
1322:
1318:
1313:
1311:
1308:
1304:
1301:(BM-40) is a
1300:
1296:
1292:
1280:
1275:
1271:
1267:
1264:
1260:
1253:
1251:
1248:
1244:
1240:
1236:
1233:
1229:
1225:
1218:
1216:
1212:
1206:
1202:
1199:
1193:
1191:
1187:
1183:
1177:
1173:
1170:
1166:
1159:
1157:
1153:
1147:
1143:
1140:
1134:
1132:
1128:
1124:
1118:
1114:
1111:
1109:RefSeq (mRNA)
1107:
1100:
1099:
1094:
1090:
1087:
1081:
1080:
1075:
1071:
1068:
1066:
1062:
1055:
1054:
1049:
1045:
1042:
1036:
1035:
1030:
1026:
1023:
1021:
1017:
1010:
1009:
1004:
1000:
997:
991:
990:
985:
981:
978:
976:
972:
969:
966:
964:
961:
957:
954:
950:
946:
939:
935:
930:
924:
921:
919:
916:
914:
911:
909:
906:
904:
901:
899:
896:
894:
891:
889:
886:
884:
881:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
833:wound healing
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
780:
778:
775:
774:
768:
765:
763:
760:
758:
755:
753:
750:
748:
745:
743:
740:
738:
735:
733:
730:
728:
725:
723:
722:mitochondrion
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
674:
672:
669:
668:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
633:
631:
628:
627:
624:
623:Gene ontology
620:
616:
604:
599:
595:
588:
583:
580:
578:
574:
566:
561:
550:
546:
542:
538:
534:
530:
526:
522:
519:body of femur
518:
514:
513:
510:
506:
501:
498:
488:
484:
480:
476:
472:
468:
464:
460:
456:
452:
451:
448:
444:
439:
436:
435:
432:
430:
426:
424:
423:
419:
418:
415:
413:
409:
405:
401:
397:
389:
384:
380:
376:
371:
361:
357:
350:
343:
337:
330:
322:
318:
314:
309:
305:
300:
296:
288:
283:
279:
275:
270:
260:
256:
249:
242:
236:
229:
225:
219:
215:
211:
206:
202:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
153:
145:
140:
133:
128:
123:
112:
110:
106:
102:
98:
92:
87:
84:
83:
79:
76:
69:
65:
60:
56:
52:
47:
42:
37:
33:
19:
4544:
4505:4-1BB ligand
4417:Fibromodulin
4122:Mucoproteins
3966:
3957:Hemicentin 1
3707:Calreticulin
3599:Sarcalumenin
3399:IP3 receptor
3191:TRP channels
3120:Ligand-gated
2937:
2922:
2907:
2844:Angiogenesis
2758:itraconazole
2636:
2541:calreticulin
2437:
2433:
2405:
2401:
2364:
2360:
2333:
2329:
2298:
2294:
2257:
2253:
2208:
2204:
2168:(2): 352–6.
2165:
2162:FEBS Letters
2161:
2130:
2126:
2095:
2091:
2065:(1): 37–47.
2062:
2058:
2023:
2019:
1982:
1978:
1956:(1): 17–28.
1953:
1949:
1918:
1914:
1883:
1879:
1830:
1826:
1789:
1785:
1758:
1754:
1705:
1701:
1691:
1666:
1662:
1656:
1634:(6): 470–8.
1631:
1627:
1621:
1586:
1582:
1572:
1547:
1544:Biochemistry
1543:
1537:
1528:
1519:
1510:
1501:
1446:
1442:
1429:
1425:
1413:angiogenesis
1398:
1366:
1346:
1317:glycoprotein
1314:
1306:
1298:
1294:
1290:
1289:
1211:NP_001277746
1208:
1186:NP_001296373
1182:NP_001296372
1179:
1156:NM_001290817
1149:
1131:NM_001309444
1127:NM_001309443
1120:
1096:
1077:
1051:
1032:
1006:
987:
967:
962:
918:pigmentation
793:ossification
712:cell surface
547:carotid body
527:aortic valve
427:
420:
285:151,686,975
272:151,661,096
147:External IDs
94:
18:SPARC (gene)
4617:Vitronectin
4612:Uteroglobin
4602:Transcortin
4575:Glycophorin
4545:Osteonectin
4530:Lactoferrin
4255:Orosomucoid
4245:Haptoglobin
4012:Osteocalcin
3992:Osteopontin
3967:Osteonectin
3741:CaM kinases
3589:Parvalbumin
3572:Neurocalcin
3567:Hippocalcin
2890:PDB gallery
2808:thalidomide
2793:tasquinimod
2723:bevacizumab
2718:angiostatin
2621:prothrombin
2601:osteopontin
2531:angiostatin
2469:Osteonectin
1405:cell-matrix
1371:acidic and
1325:osteoblasts
1297:(SPARC) or
1291:Osteonectin
465:gallbladder
386:55,314,009
373:55,285,326
125:Identifiers
36:Osteopontin
32:Osteocalcin
4632:Categories
4445:Syndecan 1
4060:Gla domain
3877:Calcitonin
3699:chaperones
3676:Troponin C
3540:Calsenilin
3525:Calretinin
3488:Calmodulin
2743:endostatin
2703:inhibitors
2652:vasostatin
2546:endostatin
2518:Endogenous
1496:, May 2017
1475:, May 2017
1452:References
535:belly cord
431:(ortholog)
168:HomoloGene
4555:Protein S
4550:Protein C
4525:Hemopexin
4515:Clusterin
4427:Keratocan
4035:C2 domain
3907:chelators
3892:Vitamin K
3887:Vitamin D
3801:proteases
3577:Recoverin
3545:Frequenin
3483:Calbindin
3475:chelators
3354:signaling
3015:Cadherins
2798:tecogalan
2778:prolactin
2682:Exogenous
2611:prolactin
2536:canstatin
1421:migration
1363:Structure
1215:NP_033268
1190:NP_003109
1152:NM_009242
1123:NM_003118
953:Orthologs
677:cytoplasm
176:GeneCards
4374:Brevican
4369:Neurocan
4364:Aggrecan
4342:Perlecan
4337:Testican
4315:Versican
4310:Biglycan
4270:Ovomucin
4040:Cadherin
3972:SIBLINGs
3925:Fibulins
3918:proteins
3809:Calpains
3712:Calnexin
3530:Gelsolin
3266:Annexins
2837:See also
2763:linomide
2633:fragment
2282:38472373
2192:22117205
2059:Genomics
2007:32528538
1814:35426082
1777:10567433
1732:32958146
1613:16041213
1492:–
1471:–
1395:Function
1373:cysteine
1329:collagen
1263:Wikidata
932:Sources:
551:gastrula
515:calvaria
4422:Lumican
4305:Decorin
4102:Protein
4050:EF hand
4027:domains
3733:kinases
3722:HSP90B1
3582:Visinin
3471:Sensors
3459:SLC24A5
2823:TNP-470
2788:suramin
2713:heparin
2454:7563094
2424:7559469
2389:1625045
2381:7034958
2352:6368555
2317:3597437
2274:3581152
2245:3489235
2213:Bibcode
2184:3410046
2149:3402455
2114:3400777
2105:1880722
2079:2838412
2050:2745554
2041:2115491
1999:2505905
1970:2338025
1937:2306517
1902:1552170
1867:1311092
1835:Bibcode
1806:1093755
1724:8119487
1683:1499220
1648:6380686
1604:1357728
1564:2790009
1494:Ensembl
1473:Ensembl
1385:EF hand
1357:introns
1319:in the
1303:protein
1065:UniProt
1020:Ensembl
959:Species
938:QuickGO
757:synapse
742:vesicle
732:nucleus
406:pattern
132:Aliases
4495:Avidin
4174:MUC5AC
3859:CAPN10
3513:CALML5
3508:CALML3
3454:SLC8B1
3442:ATP2A3
3437:ATP2A2
3432:ATP2A1
3236:SLC8A1
3231:SLC3A2
2783:SU5416
2596:Meth-2
2591:Meth-1
2586:maspin
2566:CXCL10
2475:(MeSH)
2452:
2422:
2387:
2379:
2350:
2315:
2280:
2272:
2243:
2236:386616
2233:
2190:
2182:
2147:
2112:
2102:
2077:
2048:
2038:
2005:
1997:
1968:
1935:
1900:
1865:
1855:
1812:
1804:
1775:
1730:
1722:
1681:
1646:
1611:
1601:
1562:
1355:and 9
1249:search
1247:PubMed
1098:P07214
1079:P09486
975:Entrez
577:BioGPS
264:5q33.1
156:182120
4458:Other
4389:CSPG5
4384:CSPG4
4238:Other
4229:MUC20
4224:MUC19
4219:MUC17
4214:MUC16
4209:MUC15
4204:MUC13
4199:MUC12
4179:MUC5B
4164:MUC3B
4159:MUC3A
4144:CD164
4131:Mucin
3950:FBLN5
3945:FBLN4
3940:FBLN3
3935:FBLN2
3930:FBLN1
3854:CAPN9
3849:CAPN8
3844:CAPN7
3839:CAPN6
3834:CAPN5
3829:CAPN4
3824:CAPN3
3819:CAPN2
3814:CAPN1
3783:CAMK4
3778:CAMK3
3751:CAMK2
3746:CAMK1
3717:HSPA5
3686:TNNC2
3681:TNNC1
3671:S100P
3659:SYT14
3654:SYT13
3649:SYT11
3503:CALM3
3498:CALM2
3493:CALM1
3427:SERCA
3381:cADPR
3376:NAADP
3314:A8-L2
3248:GPCRs
3100:CDH17
3095:CDH16
3090:CDH15
3085:CDH14
3080:CDH13
3075:CDH12
3070:CDH11
3065:CDH10
2753:IL-12
2748:IFN-α
2738:CM101
2667:NRP-1
2637:SPARC
2581:IL-18
2576:IL-12
2561:IFN-γ
2556:IFN-β
2551:IFN-α
2385:S2CID
2278:S2CID
2188:S2CID
2003:S2CID
1915:Blood
1858:48433
1810:S2CID
1728:S2CID
1353:exons
1307:SPARC
1008:20692
968:Mouse
963:Human
934:Amigo
453:tibia
429:Mouse
422:Human
369:Start
304:Mouse
268:Start
201:Human
180:SPARC
172:31132
164:98373
139:SPARC
44:SPARC
4570:CD43
4485:CD70
4470:ADAM
4379:CD44
4194:MUC8
4189:MUC7
4184:MUC6
4169:MUC4
4154:MUC2
4149:MUC1
4139:CD43
4112:and
3666:S100
3644:SYT9
3639:SYT7
3634:SYT6
3629:SYT5
3624:SYT4
3619:SYT3
3614:SYT2
3609:SYT1
3550:GUCA
3473:and
3206:TRPV
3201:TRPC
3196:TRPA
3060:CDH9
3055:CDH8
3050:CDH7
3045:CDH6
3040:CDH5
3035:CDH4
3030:CDH3
3025:CDH2
3020:CDH1
2988:and
2938:1sra
2923:1nub
2908:1bmo
2672:CDAI
2657:VEGI
2647:TIMP
2571:IL-4
2450:PMID
2420:PMID
2377:PMID
2361:Cell
2348:PMID
2313:PMID
2270:PMID
2241:PMID
2180:PMID
2145:PMID
2110:PMID
2075:PMID
2046:PMID
1995:PMID
1966:PMID
1933:PMID
1898:PMID
1863:PMID
1802:PMID
1773:PMID
1720:PMID
1679:PMID
1644:PMID
1609:PMID
1560:PMID
1419:and
1343:Gene
1335:and
1321:bone
1310:gene
989:6678
412:Bgee
360:Band
321:Chr.
259:Band
218:Chr.
152:OMIM
109:2V53
105:1SRA
101:1NUB
97:1BMO
78:RCSB
75:PDBe
3371:IP3
3339:A13
3334:A12
3329:A11
3324:A10
2627:-2)
2442:doi
2438:253
2410:doi
2406:270
2369:doi
2338:doi
2334:259
2303:doi
2299:262
2262:doi
2258:248
2231:PMC
2221:doi
2170:doi
2166:236
2135:doi
2131:175
2100:PMC
2096:132
2067:doi
2036:PMC
2028:doi
2024:109
1987:doi
1958:doi
1923:doi
1888:doi
1853:PMC
1843:doi
1794:doi
1763:doi
1710:doi
1671:doi
1667:281
1636:doi
1599:PMC
1591:doi
1587:242
1552:doi
1369:kDa
382:End
281:End
184:OMA
160:MGI
68:PDB
34:or
4634::
4437:HS
4409:KS
4362::
4352:CS
4329:CS
4325:HS
4297:DS
4293:CS
4108::
4104:,
3560:1B
3555:1A
3319:A9
3309:A8
3304:A7
3299:A6
3294:A5
3289:A4
3284:A3
3279:A2
3274:A1
2984::
2448:.
2436:.
2418:.
2404:.
2400:.
2383:.
2375:.
2365:26
2363:.
2346:.
2332:.
2328:.
2311:.
2297:.
2293:.
2276:.
2268:.
2256:.
2239:.
2229:.
2219:.
2209:83
2207:.
2203:.
2186:.
2178:.
2164:.
2160:.
2143:.
2129:.
2125:.
2108:.
2094:.
2090:.
2073:.
2061:.
2044:.
2034:.
2022:.
2018:.
2001:.
1993:.
1983:45
1981:.
1964:.
1954:24
1952:.
1948:.
1931:.
1919:75
1917:.
1913:.
1896:.
1884:40
1882:.
1878:.
1861:.
1851:.
1841:.
1831:89
1829:.
1825:.
1808:.
1800:.
1790:36
1788:.
1771:.
1759:47
1757:.
1753:.
1726:.
1718:.
1704:.
1700:.
1677:.
1665:.
1642:.
1632:62
1630:.
1607:.
1597:.
1585:.
1581:.
1558:.
1548:28
1546:.
1527:.
1509:.
1480:^
1459:^
1415:,
1349:kb
1312:.
936:/
388:bp
375:bp
287:bp
274:bp
182:;
178::
174:;
170::
166:;
162::
158:;
154::
107:,
103:,
99:,
4327:/
4295:/
4094:e
4087:t
4080:v
3771:G
3766:D
3761:B
3756:A
3184:T
3179:R
3174:P
3169:N
3164:L
2974:e
2967:t
2960:v
2883:e
2876:t
2869:v
2701:3
2699:β
2697:V
2695:α
2623:(
2502:e
2495:t
2488:v
2456:.
2444::
2426:.
2412::
2391:.
2371::
2354:.
2340::
2319:.
2305::
2284:.
2264::
2247:.
2223::
2215::
2194:.
2172::
2151:.
2137::
2116:.
2081:.
2069::
2063:2
2052:.
2030::
2009:.
1989::
1972:.
1960::
1939:.
1925::
1904:.
1890::
1869:.
1845::
1837::
1816:.
1796::
1779:.
1765::
1734:.
1712::
1706:8
1685:.
1673::
1650:.
1638::
1615:.
1593::
1566:.
1554::
1531:.
1513:.
306:)
203:)
186::
38:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
