302:
279:
1764:
176:
201:
1779:
567:
560:
553:
308:
207:
29:
1804:
55:
1560:
Fowler M, Borazanci E, McGhee L, Pylant SW, Williams BJ, Glass J, et al. (January 2006). "RUNX1 (AML-1) and RUNX2 (AML-3) cooperate with prostate-derived Ets factor to activate transcription from the PSA upstream regulatory region".
1763:
1530:
Wang Y, Feng L, Said M, Balderman S, Fayazi Z, Liu Y, et al. (May 2005). "Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site".
1463:
Ghadersohi A, Odunsi K, Lele S, Collins Y, Greco WR, Winston J, et al. (February 2004). "Prostate derived Ets transcription factor shows better tumor-association than other cancer-associated molecules".
1442:
Feldman RJ, Sementchenko VI, Gayed M, Fraig MM, Watson DK (August 2003). "Pdef expression in human breast cancer is correlated with invasive potential and altered gene expression".
1778:
315:
214:
1205:"PDEF, a novel prostate epithelium-specific ets transcription factor, interacts with the androgen receptor and activates prostate-specific antigen gene expression"
1641:
Rodabaugh KJ, Mhawech-Fauceglia P, Groth J, Lele S, Sood AK (January 2007). "Prostate-derived Ets factor is overexpressed in serous epithelial ovarian tumors".
1092:
PDEF is an ETS transcription factor expressed in prostate epithelial cells. It acts as an androgen-independent transactivator of PSA (MIM 176820) expression.
1386:
Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter".
1296:
Chen H, Nandi AK, Li X, Bieberich CJ (January 2002). "NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter".
800:
781:
137:
1772:: Analysis of the 2.0A crystal structure of the protein-DNA complex of human PDEF Ets domain bound to the prostate specific antigen regulatory site
1873:
1849:
1743:
1185:
1167:
1868:
1357:
Yamada N, Tamai Y, Miyamoto H, Nozaki M (January 2000). "Cloning and expression of the mouse Pse gene encoding a novel Ets family member".
301:
1328:
Lance V (1976). "Studies on the annual reproductive cycle of the female cobra, Naja naja. Seasonal variation in plasma inorganic ions".
1493:
Chen H, Bieberich CJ (January 2005). "Structural and functional analysis of domains mediating interaction between NKX-3.1 and PDEF".
1023:
1016:
278:
1282:
1154:
1133:
1150:
200:
175:
52:
1129:
117:
1101:
314:
213:
307:
206:
1842:
1736:
845:
125:
826:
1409:"p62 overexpression in breast tumors and regulation by prostate-derived Ets factor in breast cancer cells"
1835:
1729:
189:
104:
999:
970:
944:
915:
1666:
1586:
1518:
149:
995:
974:
940:
919:
1709:
1658:
1629:
1578:
1548:
1510:
1481:
1451:
1430:
1395:
1374:
1345:
1305:
1261:
1226:
566:
559:
552:
97:
45:
1819:
1203:
Oettgen P, Finger E, Sun Z, Akbarali Y, Thamrongsak U, Boltax J, et al. (January 2000).
1699:
1691:
1650:
1619:
1611:
1570:
1540:
1502:
1473:
1420:
1366:
1337:
1253:
1216:
394:
325:
269:
224:
145:
1787:: Solution structure of the SAM_PNT-domain of ETS transcription factor PDEF (Prostate ets)
1678:
Park KS, Korfhagen TR, Bruno MD, Kitzmiller JA, Wan H, Wert SE, et al. (April 2007).
369:
1704:
1679:
1654:
1624:
1599:
28:
1370:
1341:
715:
710:
705:
700:
695:
690:
685:
680:
675:
670:
665:
660:
644:
628:
623:
618:
613:
608:
1862:
595:
1670:
1590:
1522:
129:
1815:
387:
166:
1615:
1244:
Johannessen JV, Finseth I (January 1983). "Electron micrographs in five minutes".
1598:
Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS (December 2005).
153:
1190:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1172:
National Center for
Biotechnology Information, U.S. National Library of Medicine
470:
1257:
286:
183:
133:
745:
530:
408:
353:
340:
252:
239:
141:
1713:
1662:
1633:
1582:
1552:
1514:
1485:
1455:
1434:
1425:
1408:
1399:
1378:
1309:
1283:"Entrez Gene: SPDEF SAM pointed domain containing ets transcription factor"
1230:
1221:
1204:
1265:
1063:
1058:
1047:
890:
871:
108:, PDEF, bA375E1.3, SAM pointed domain containing ETS transcription factor
1477:
619:
DNA-binding transcription repressor activity, RNA polymerase II-specific
1349:
1079:
857:
812:
1574:
1544:
1506:
74:
1695:
1105:
1031:
767:
629:
DNA-binding transcription factor activity, RNA polymerase II-specific
1803:
1680:"SPDEF regulates goblet cell hyperplasia in the airway epithelium"
1330:
Comparative
Biochemistry and Physiology. A, Comparative Physiology
730:
726:
1811:
1086:
575:
121:
1725:
1600:"Novel role for PDEF in epithelial cell migration and invasion"
1407:
Thompson HG, Harris JW, Wold BJ, Lin F, Brody JP (April 2003).
1721:
706:
positive regulation of transcription by RNA polymerase II
676:
negative regulation of transcription by RNA polymerase II
377:
1823:
1076:
SAM pointed domain-containing Ets transcription factor
542:
988:
963:
933:
908:
1146:
1144:
1142:
1125:
1123:
1121:
324:
223:
1643:International Journal of Gynecological Pathology
716:regulation of transcription by RNA polymerase II
16:Protein-coding gene in the species Homo sapiens
1151:GRCm38: Ensembl release 89: ENSMUSG00000024215
1843:
1737:
8:
1130:GRCh38: Ensembl release 89: ENSG00000124664
701:positive regulation of cell fate commitment
681:negative regulation of cell fate commitment
1850:
1836:
1744:
1730:
1722:
741:
671:regulation of transcription, DNA-templated
591:
365:
264:
161:
63:
1703:
1623:
1424:
1220:
609:DNA-binding transcription factor activity
1277:
1275:
711:positive regulation of apoptotic process
1759:
1117:
691:intestinal epithelial cell development
481:crypt of lieberkuhn of small intestine
18:
1684:The Journal of Clinical Investigation
329:
290:
285:
228:
187:
182:
7:
1800:
1798:
1209:The Journal of Biological Chemistry
1822:. You can help Knowledge (XXG) by
1655:10.1097/01.pgp.0000225386.41244.bd
985:
960:
930:
905:
881:
862:
836:
817:
791:
772:
661:multicellular organism development
547:
465:
403:
382:
14:
1082:that in humans is encoded by the
1802:
1777:
1762:
1563:Journal of Cellular Biochemistry
1495:Journal of Cellular Biochemistry
686:lung goblet cell differentiation
565:
558:
551:
313:
306:
300:
277:
212:
205:
199:
174:
27:
576:More reference expression data
531:More reference expression data
439:olfactory zone of nasal mucosa
1:
1874:Human chromosome 6 gene stubs
1616:10.1158/0008-5472.CAN-05-1196
1371:10.1016/S0378-1119(99)00484-9
1342:10.1016/S0300-9629(76)80037-0
624:sequence-specific DNA binding
298:
197:
696:transcription, DNA-templated
1869:Genes on human chromosome 6
1890:
1797:
427:mucosa of transverse colon
1757:
1258:10.3109/01913128309140576
1246:Ultrastructural Pathology
1186:"Mouse PubMed Reference:"
1168:"Human PubMed Reference:"
1062:
1057:
1053:
1046:
1030:
1011:
992:
967:
956:
937:
912:
901:
888:
884:
869:
865:
856:
843:
839:
824:
820:
811:
798:
794:
779:
775:
766:
751:
744:
740:
724:
594:
590:
573:
550:
541:
528:
477:
468:
415:
406:
376:
368:
364:
347:
334:
297:
276:
267:
263:
246:
233:
196:
173:
164:
160:
115:
112:
102:
95:
90:
71:
66:
49:
44:
39:
35:
26:
21:
1100:SPDEF has been shown to
1024:Chr 17: 27.93 – 27.95 Mb
1017:Chr 6: 34.54 – 34.56 Mb
451:mucosa of sigmoid colon
1426:10.1038/sj.onc.1206325
1222:10.1074/jbc.275.2.1216
493:mucous cell of stomach
489:epithelium of stomach
292:Chromosome 17 (mouse)
666:cell differentiation
190:Chromosome 6 (human)
67:List of PDB id codes
40:Available structures
1610:(24): 11572–11580.
1478:10.3892/or.11.2.453
1810:This article on a
846:ENSMUSG00000024215
654:Biological process
638:Cellular component
602:Molecular function
443:buccal mucosa cell
1831:
1830:
1795:
1794:
1575:10.1002/jcb.20664
1545:10.1021/bi047352t
1539:(19): 7095–7106.
1507:10.1002/jcb.20297
1450:(15): 4626–4631.
1419:(15): 2322–2333.
1073:
1072:
1069:
1068:
1042:
1041:
1007:
1006:
982:
981:
952:
951:
927:
926:
897:
896:
878:
877:
852:
851:
833:
832:
807:
806:
788:
787:
736:
735:
586:
585:
582:
581:
537:
536:
524:
523:
462:
461:
360:
359:
259:
258:
154:SPDEF - orthologs
86:
85:
82:
81:
50:Ortholog search:
1881:
1852:
1845:
1838:
1806:
1799:
1781:
1766:
1746:
1739:
1732:
1723:
1717:
1707:
1696:10.1172/JCI29176
1674:
1637:
1627:
1594:
1556:
1526:
1489:
1466:Oncology Reports
1459:
1438:
1428:
1403:
1382:
1353:
1314:
1313:
1293:
1287:
1286:
1279:
1270:
1269:
1241:
1235:
1234:
1224:
1215:(2): 1216–1225.
1200:
1194:
1193:
1182:
1176:
1175:
1164:
1158:
1148:
1137:
1127:
1055:
1054:
1026:
1019:
1002:
986:
977:
961:
957:RefSeq (protein)
947:
931:
922:
906:
882:
863:
837:
818:
792:
773:
742:
592:
578:
569:
562:
555:
548:
533:
517:seminal vesicula
473:
471:Top expressed in
466:
455:lactiferous duct
423:nasal epithelium
411:
409:Top expressed in
404:
383:
366:
356:
343:
332:
317:
310:
304:
293:
281:
265:
255:
242:
231:
216:
209:
203:
192:
178:
162:
156:
107:
100:
77:
64:
58:
37:
36:
31:
19:
1889:
1888:
1884:
1883:
1882:
1880:
1879:
1878:
1859:
1858:
1857:
1856:
1796:
1791:
1788:
1782:
1773:
1767:
1753:
1750:
1720:
1677:
1640:
1604:Cancer Research
1597:
1559:
1529:
1492:
1462:
1444:Cancer Research
1441:
1406:
1388:Cancer Research
1385:
1356:
1327:
1323:
1321:Further reading
1318:
1317:
1298:Cancer Research
1295:
1294:
1290:
1281:
1280:
1273:
1243:
1242:
1238:
1202:
1201:
1197:
1184:
1183:
1179:
1166:
1165:
1161:
1149:
1140:
1128:
1119:
1114:
1098:
1064:View/Edit Mouse
1059:View/Edit Human
1022:
1015:
1012:Location (UCSC)
998:
994:
973:
969:
943:
939:
918:
914:
827:ENSG00000124664
720:
649:
633:
574:
564:
563:
557:
556:
529:
520:
515:
511:
507:
503:
499:
495:
491:
487:
483:
469:
458:
453:
449:
445:
441:
437:
435:mucosa of ileum
433:
429:
425:
421:
407:
351:
338:
331:17|17 A3.3
330:
320:
319:
318:
311:
291:
268:Gene location (
250:
237:
229:
219:
218:
217:
210:
188:
165:Gene location (
116:
103:
96:
73:
51:
17:
12:
11:
5:
1887:
1885:
1877:
1876:
1871:
1861:
1860:
1855:
1854:
1847:
1840:
1832:
1829:
1828:
1807:
1793:
1792:
1790:
1789:
1783:
1776:
1774:
1768:
1761:
1758:
1755:
1754:
1751:
1749:
1748:
1741:
1734:
1726:
1719:
1718:
1690:(4): 978–988.
1675:
1638:
1595:
1557:
1527:
1501:(1): 168–177.
1490:
1472:(2): 453–458.
1460:
1439:
1404:
1394:(2): 338–340.
1383:
1365:(2): 267–274.
1354:
1336:(3): 285–289.
1324:
1322:
1319:
1316:
1315:
1304:(2): 338–340.
1288:
1271:
1236:
1195:
1177:
1159:
1138:
1116:
1115:
1113:
1110:
1097:
1094:
1071:
1070:
1067:
1066:
1061:
1051:
1050:
1044:
1043:
1040:
1039:
1037:
1035:
1028:
1027:
1020:
1013:
1009:
1008:
1005:
1004:
990:
989:
983:
980:
979:
965:
964:
958:
954:
953:
950:
949:
935:
934:
928:
925:
924:
910:
909:
903:
899:
898:
895:
894:
886:
885:
879:
876:
875:
867:
866:
860:
854:
853:
850:
849:
841:
840:
834:
831:
830:
822:
821:
815:
809:
808:
805:
804:
796:
795:
789:
786:
785:
777:
776:
770:
764:
763:
758:
753:
749:
748:
738:
737:
734:
733:
722:
721:
719:
718:
713:
708:
703:
698:
693:
688:
683:
678:
673:
668:
663:
657:
655:
651:
650:
648:
647:
641:
639:
635:
634:
632:
631:
626:
621:
616:
611:
605:
603:
599:
598:
588:
587:
584:
583:
580:
579:
571:
570:
545:
539:
538:
535:
534:
526:
525:
522:
521:
519:
518:
514:
513:female urethra
510:
506:
502:
498:
497:pyloric antrum
494:
490:
486:
485:gastric mucosa
482:
478:
475:
474:
463:
460:
459:
457:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
416:
413:
412:
400:
399:
391:
380:
374:
373:
370:RNA expression
362:
361:
358:
357:
349:
345:
344:
336:
333:
328:
322:
321:
312:
305:
299:
295:
294:
289:
283:
282:
274:
273:
261:
260:
257:
256:
248:
244:
243:
235:
232:
227:
221:
220:
211:
204:
198:
194:
193:
186:
180:
179:
171:
170:
158:
157:
114:
110:
109:
101:
93:
92:
88:
87:
84:
83:
80:
79:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1886:
1875:
1872:
1870:
1867:
1866:
1864:
1853:
1848:
1846:
1841:
1839:
1834:
1833:
1827:
1825:
1821:
1817:
1813:
1808:
1805:
1801:
1786:
1780:
1775:
1771:
1765:
1760:
1756:
1747:
1742:
1740:
1735:
1733:
1728:
1727:
1724:
1715:
1711:
1706:
1701:
1697:
1693:
1689:
1685:
1681:
1676:
1672:
1668:
1664:
1660:
1656:
1652:
1648:
1644:
1639:
1635:
1631:
1626:
1621:
1617:
1613:
1609:
1605:
1601:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1568:
1564:
1558:
1554:
1550:
1546:
1542:
1538:
1534:
1528:
1524:
1520:
1516:
1512:
1508:
1504:
1500:
1496:
1491:
1487:
1483:
1479:
1475:
1471:
1467:
1461:
1457:
1453:
1449:
1445:
1440:
1436:
1432:
1427:
1422:
1418:
1414:
1410:
1405:
1401:
1397:
1393:
1389:
1384:
1380:
1376:
1372:
1368:
1364:
1360:
1355:
1351:
1347:
1343:
1339:
1335:
1331:
1326:
1325:
1320:
1311:
1307:
1303:
1299:
1292:
1289:
1284:
1278:
1276:
1272:
1267:
1263:
1259:
1255:
1252:(1): 97–100.
1251:
1247:
1240:
1237:
1232:
1228:
1223:
1218:
1214:
1210:
1206:
1199:
1196:
1191:
1187:
1181:
1178:
1173:
1169:
1163:
1160:
1156:
1152:
1147:
1145:
1143:
1139:
1135:
1131:
1126:
1124:
1122:
1118:
1111:
1109:
1107:
1103:
1095:
1093:
1090:
1088:
1085:
1081:
1077:
1065:
1060:
1056:
1052:
1049:
1045:
1038:
1036:
1033:
1029:
1025:
1021:
1018:
1014:
1010:
1003:
1001:
997:
991:
987:
984:
978:
976:
972:
966:
962:
959:
955:
948:
946:
942:
936:
932:
929:
923:
921:
917:
911:
907:
904:
902:RefSeq (mRNA)
900:
893:
892:
887:
883:
880:
874:
873:
868:
864:
861:
859:
855:
848:
847:
842:
838:
835:
829:
828:
823:
819:
816:
814:
810:
803:
802:
797:
793:
790:
784:
783:
778:
774:
771:
769:
765:
762:
759:
757:
754:
750:
747:
743:
739:
732:
728:
723:
717:
714:
712:
709:
707:
704:
702:
699:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
658:
656:
653:
652:
646:
643:
642:
640:
637:
636:
630:
627:
625:
622:
620:
617:
615:
612:
610:
607:
606:
604:
601:
600:
597:
596:Gene ontology
593:
589:
577:
572:
568:
561:
554:
549:
546:
544:
540:
532:
527:
516:
512:
508:
505:parotid gland
504:
500:
496:
492:
488:
484:
480:
479:
476:
472:
467:
464:
454:
450:
446:
442:
438:
434:
430:
426:
422:
419:parotid gland
418:
417:
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38:
34:
30:
25:
20:
1824:expanding it
1816:chromosome 6
1809:
1784:
1769:
1687:
1683:
1649:(1): 10–15.
1646:
1642:
1607:
1603:
1566:
1562:
1536:
1533:Biochemistry
1532:
1498:
1494:
1469:
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1416:
1412:
1391:
1387:
1362:
1358:
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1249:
1245:
1239:
1212:
1208:
1198:
1189:
1180:
1171:
1162:
1099:
1096:Interactions
1091:
1083:
1075:
1074:
1000:NP_001344657
993:
971:NP_001239223
968:
945:NM_001357728
938:
916:NM_001252294
913:
889:
870:
844:
825:
799:
780:
760:
755:
393:
386:
113:External IDs
72:
1752:PDB gallery
1569:(1): 1–17.
614:DNA binding
501:Paneth cell
352:27,947,929
339:27,933,326
251:34,556,333
238:34,537,802
91:Identifiers
1863:Categories
1157:, May 2017
1136:, May 2017
1112:References
397:(ortholog)
134:HomoloGene
1814:on human
996:NP_038919
975:NP_036523
941:NM_013891
920:NM_012391
746:Orthologs
142:GeneCards
1714:17347682
1671:25880565
1663:17197890
1634:16357167
1591:20541109
1583:16237704
1553:15882048
1523:46494570
1515:15523673
1486:14719083
1456:12907642
1435:12700667
1413:Oncogene
1400:11809674
1379:10675039
1310:11809674
1231:10625666
1153:–
1132:–
1102:interact
1048:Wikidata
725:Sources:
509:duodenum
431:prostate
1705:1810569
1625:2919290
1266:6857767
1155:Ensembl
1134:Ensembl
1080:protein
858:UniProt
813:Ensembl
752:Species
731:QuickGO
645:nucleus
447:trachea
372:pattern
230:6p21.31
130:1353422
98:Aliases
1712:
1702:
1669:
1661:
1632:
1622:
1589:
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1551:
1521:
1513:
1484:
1454:
1433:
1398:
1377:
1348:
1308:
1264:
1229:
1106:NKX3-1
1034:search
1032:PubMed
891:Q9WTP3
872:O95238
768:Entrez
543:BioGPS
122:608144
1818:is a
1667:S2CID
1587:S2CID
1519:S2CID
1104:with
1084:SPDEF
1078:is a
801:30051
782:25803
761:Mouse
756:Human
727:Amigo
395:Mouse
388:Human
335:Start
270:Mouse
234:Start
167:Human
146:SPDEF
105:SPDEF
22:SPDEF
1820:stub
1812:gene
1785:2dkx
1770:1yo5
1710:PMID
1659:PMID
1630:PMID
1579:PMID
1549:PMID
1511:PMID
1482:PMID
1452:PMID
1431:PMID
1396:PMID
1375:PMID
1359:Gene
1350:2437
1346:PMID
1306:PMID
1262:PMID
1227:PMID
1087:gene
378:Bgee
326:Band
287:Chr.
225:Band
184:Chr.
138:8231
118:OMIM
75:2DKX
56:RCSB
53:PDBe
1700:PMC
1692:doi
1688:117
1651:doi
1620:PMC
1612:doi
1571:doi
1541:doi
1503:doi
1474:doi
1421:doi
1367:doi
1363:241
1338:doi
1254:doi
1217:doi
1213:275
348:End
247:End
150:OMA
126:MGI
46:PDB
1865::
1708:.
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1392:62
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1300:.
1274:^
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1188:.
1170:.
1141:^
1120:^
1108:.
1089:.
729:/
354:bp
341:bp
253:bp
240:bp
148:;
144::
140:;
136::
132:;
128::
124:;
120::
1851:e
1844:t
1837:v
1826:.
1745:e
1738:t
1731:v
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1233:.
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272:)
169:)
152::
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