297:
274:
171:
196:
548:
555:
303:
202:
1556:
50:
1076:
SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).
1461:
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian
Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1".
1432:
Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human
Sprouty4 gene, a novel regulator of lung morphogenesis".
310:
209:
768:
749:
132:
1498:
Leeksma OC, Van
Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002).
1263:
Leeksma OC, Van
Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002).
1635:
1601:
1187:
1169:
1620:
296:
992:
999:
273:
1249:
1156:
1135:
1152:
195:
170:
47:
1131:
112:
1543:
provides an overview of all the structure information available in the PDB for Human
Protein sprouty homolog 4 (SPRY4)
1086:
309:
208:
302:
201:
1594:
1207:"FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells"
813:
120:
1391:"Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer"
1630:
794:
1102:
1587:
184:
99:
1625:
950:
946:
942:
891:
887:
883:
1500:"Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1"
1486:
1420:
1265:"Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1"
144:
975:
954:
916:
895:
547:
1311:"Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping"
1521:
1478:
1449:
1412:
1377:
1342:
1286:
1228:
554:
92:
40:
1571:
1511:
1470:
1441:
1402:
1367:
1332:
1322:
1276:
1218:
389:
320:
264:
219:
140:
1052:
364:
1309:
Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D (2008).
1337:
1310:
683:
678:
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612:
596:
1614:
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1516:
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1281:
1264:
1107:
583:
1490:
1424:
124:
1567:
382:
161:
148:
1192:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1174:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1445:
465:
281:
178:
128:
713:
525:
403:
348:
335:
247:
234:
136:
1525:
1482:
1453:
1416:
1381:
1372:
1355:
1346:
1327:
1290:
1232:
1223:
1206:
1039:
1034:
674:
negative regulation of fibroblast growth factor receptor signaling pathway
1023:
858:
839:
1407:
1390:
1058:
825:
780:
1434:
American
Journal of Physiology. Lung Cellular and Molecular Physiology
69:
1007:
735:
1555:
1474:
1356:"A functional interaction between sprouty proteins and caveolin-1"
1090:
698:
694:
1563:
1065:
563:
116:
1389:
Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006).
1354:
Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006).
372:
1575:
684:
negative regulation of Ras protein signal transduction
537:
1250:"Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)"
968:
935:
909:
876:
1148:
1146:
1144:
1127:
1125:
1123:
319:
218:
16:Protein-coding gene in the species Homo sapiens
1153:GRCm38: Ensembl release 89: ENSMUSG00000024427
1595:
8:
664:negative regulation of ERK1 and ERK2 cascade
1211:International Journal of Molecular Medicine
1132:GRCh38: Ensembl release 89: ENSG00000187678
1602:
1588:
709:
679:negative regulation of MAP kinase activity
579:
360:
259:
156:
103:, HH17, sprouty RTK signaling antagonist 4
58:
1515:
1406:
1371:
1336:
1326:
1280:
1222:
1244:
1242:
1119:
18:
324:
285:
280:
223:
182:
177:
7:
1552:
1550:
1360:The Journal of Biological Chemistry
1574:. You can help Knowledge (XXG) by
965:
932:
906:
873:
849:
830:
804:
785:
759:
740:
659:multicellular organism development
542:
460:
398:
377:
14:
1061:that in humans is encoded by the
669:regulation of signal transduction
1554:
1517:10.1046/j.1432-1033.2002.02921.x
1504:European Journal of Biochemistry
1282:10.1046/j.1432-1033.2002.02921.x
1269:European Journal of Biochemistry
553:
546:
308:
301:
295:
272:
207:
200:
194:
169:
564:More reference expression data
526:More reference expression data
1:
1636:Human chromosome 5 gene stubs
1205:Katoh Y, Katoh M (Mar 2006).
293:
192:
1621:Genes on human chromosome 5
1652:
1549:
1446:10.1152/ajplung.00430.2003
1188:"Mouse PubMed Reference:"
1170:"Human PubMed Reference:"
1038:
1033:
1029:
1022:
1006:
993:Chr 5: 142.31 – 142.33 Mb
987:
972:
939:
928:
913:
880:
869:
856:
852:
837:
833:
824:
811:
807:
792:
788:
779:
766:
762:
747:
743:
734:
719:
712:
708:
692:
582:
578:
561:
545:
536:
523:
472:
463:
430:Descending thoracic aorta
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1085:SPRY4 has been shown to
1000:Chr 18: 38.72 – 38.73 Mb
426:upper lobe of left lung
1373:10.1074/jbc.M603921200
1328:10.1186/1471-244X-8-11
1103:MAPK signaling pathway
496:lumbar spinal ganglion
1224:10.3892/ijmm.17.3.529
438:right coronary artery
326:18 B3|18 20.5 cM
287:Chromosome 18 (mouse)
414:left coronary artery
185:Chromosome 5 (human)
62:List of PDB id codes
35:Available structures
1463:Nature Cell Biology
1562:This article on a
1408:10.1002/pros.20353
814:ENSMUSG00000024427
652:Biological process
606:Cellular component
590:Molecular function
450:left adrenal gland
442:lower lobe of lung
1583:
1582:
1049:
1048:
1045:
1044:
1018:
1017:
983:
982:
962:
961:
924:
923:
903:
902:
865:
864:
846:
845:
820:
819:
801:
800:
775:
774:
756:
755:
704:
703:
574:
573:
570:
569:
532:
531:
519:
518:
512:nasolacrimal duct
504:perirhinal cortex
500:entorhinal cortex
457:
456:
355:
354:
254:
253:
149:SPRY4 - orthologs
81:
80:
77:
76:
45:Ortholog search:
1643:
1604:
1597:
1590:
1558:
1551:
1529:
1519:
1494:
1457:
1428:
1410:
1385:
1375:
1366:(39): 29201–12.
1350:
1340:
1330:
1295:
1294:
1284:
1260:
1254:
1253:
1246:
1237:
1236:
1226:
1202:
1196:
1195:
1184:
1178:
1177:
1166:
1160:
1150:
1139:
1129:
1031:
1030:
1002:
995:
978:
966:
957:
933:
929:RefSeq (protein)
919:
907:
898:
874:
850:
831:
805:
786:
760:
741:
710:
580:
566:
557:
550:
543:
528:
508:Ileal epithelium
476:secondary oocyte
468:
466:Top expressed in
461:
434:cartilage tissue
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
1651:
1650:
1646:
1645:
1644:
1642:
1641:
1640:
1611:
1610:
1609:
1608:
1547:
1537:
1532:
1510:(10): 2546–56.
1497:
1460:
1431:
1388:
1353:
1308:
1304:
1302:Further reading
1299:
1298:
1275:(10): 2546–56.
1262:
1261:
1257:
1248:
1247:
1240:
1204:
1203:
1199:
1186:
1185:
1181:
1168:
1167:
1163:
1151:
1142:
1130:
1121:
1116:
1099:
1083:
1074:
1053:Protein sprouty
1040:View/Edit Mouse
1035:View/Edit Human
998:
991:
988:Location (UCSC)
974:
953:
949:
945:
941:
915:
894:
890:
886:
882:
795:ENSG00000187678
688:
647:
623:cell projection
618:plasma membrane
613:ruffle membrane
601:
597:protein binding
562:
552:
551:
524:
515:
510:
506:
502:
498:
494:
490:
486:
482:
478:
464:
453:
448:
446:tibial arteries
444:
440:
436:
432:
428:
424:
422:ascending aorta
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
1649:
1647:
1639:
1638:
1633:
1631:Human proteins
1628:
1623:
1613:
1612:
1607:
1606:
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1592:
1584:
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1559:
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1535:External links
1533:
1531:
1530:
1495:
1475:10.1038/ncb978
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1429:
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1351:
1315:BMC Psychiatry
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633:focal adhesion
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492:left lung lobe
489:
485:
484:tail of embryo
481:
480:primary oocyte
477:
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469:
458:
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365:RNA expression
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1513:
1509:
1505:
1501:
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1492:
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1484:
1480:
1476:
1472:
1469:(5): 427–32.
1468:
1464:
1459:
1455:
1451:
1447:
1443:
1439:
1435:
1430:
1426:
1422:
1418:
1414:
1409:
1404:
1401:(6): 613–24.
1400:
1396:
1392:
1387:
1383:
1379:
1374:
1369:
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1361:
1357:
1352:
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1239:
1234:
1230:
1225:
1220:
1217:(3): 529–32.
1216:
1212:
1208:
1201:
1198:
1193:
1189:
1183:
1180:
1175:
1171:
1165:
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1147:
1145:
1141:
1137:
1133:
1128:
1126:
1124:
1120:
1113:
1109:
1108:Ras subfamily
1106:
1104:
1101:
1100:
1096:
1094:
1092:
1088:
1080:
1078:
1071:
1069:
1067:
1064:
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1028:
1025:
1021:
1014:
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1005:
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994:
990:
986:
979:
977:
971:
967:
964:
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956:
952:
948:
944:
938:
934:
931:
927:
920:
918:
912:
908:
905:
899:
897:
893:
889:
885:
879:
875:
872:
870:RefSeq (mRNA)
868:
861:
860:
855:
851:
848:
842:
841:
836:
832:
829:
827:
823:
816:
815:
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784:
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778:
771:
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758:
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751:
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742:
739:
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733:
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621:
619:
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604:
598:
595:
594:
592:
589:
588:
585:
584:Gene ontology
581:
577:
565:
560:
556:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
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491:
487:
483:
479:
475:
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471:
467:
462:
459:
449:
445:
441:
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429:
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421:
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71:
65:
60:
57:
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52:
49:
42:
38:
33:
29:
25:
20:
1576:expanding it
1568:chromosome 5
1561:
1546:
1507:
1503:
1466:
1462:
1440:(1): L52-9.
1437:
1433:
1398:
1395:The Prostate
1394:
1363:
1359:
1318:
1314:
1272:
1268:
1258:
1214:
1210:
1200:
1191:
1182:
1173:
1164:
1084:
1081:Interactions
1075:
1062:
1051:
1050:
973:
951:NP_001280219
947:NP_001280218
943:NP_001120968
940:
914:
892:NM_001293290
888:NM_001293289
884:NM_001127496
881:
857:
838:
812:
793:
767:
748:
728:
723:
388:
381:
246:142,326,455
233:142,310,427
108:External IDs
67:
347:38,734,468
334:38,719,300
86:Identifiers
1626:SPR domain
1615:Categories
1159:, May 2017
1138:, May 2017
1114:References
418:right lung
392:(ortholog)
129:HomoloGene
1566:on human
1055:homolog 4
976:NP_036028
955:NP_112226
917:NM_011898
896:NM_030964
714:Orthologs
638:cytoplasm
137:GeneCards
1526:12027893
1491:33846459
1483:12717443
1454:14977631
1425:43803094
1417:16388505
1382:16877379
1347:18298822
1291:12027893
1233:16465403
1155:–
1134:–
1097:See also
1087:interact
1072:Function
1024:Wikidata
693:Sources:
628:membrane
1541:PDBe-KB
1338:2268687
1157:Ensembl
1136:Ensembl
1059:protein
826:UniProt
781:Ensembl
720:Species
699:QuickGO
643:cytosol
367:pattern
125:1345144
93:Aliases
1524:
1489:
1481:
1452:
1423:
1415:
1380:
1345:
1335:
1321:: 11.
1289:
1231:
1010:search
1008:PubMed
859:Q9WTP2
840:Q9C004
736:Entrez
538:BioGPS
488:zygote
225:5q31.3
117:607984
1570:is a
1487:S2CID
1421:S2CID
1091:TESK1
1089:with
1063:SPRY4
1057:is a
769:24066
750:81848
729:Mouse
724:Human
695:Amigo
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
141:SPRY4
100:SPRY4
22:SPRY4
1572:stub
1564:gene
1522:PMID
1479:PMID
1450:PMID
1413:PMID
1378:PMID
1343:PMID
1287:PMID
1229:PMID
1066:gene
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
133:8042
113:OMIM
70:3BUN
51:RCSB
48:PDBe
1512:doi
1508:269
1471:doi
1442:doi
1438:287
1403:doi
1368:doi
1364:281
1333:PMC
1323:doi
1277:doi
1273:269
1219:doi
343:End
242:End
145:OMA
121:MGI
41:PDB
1617::
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1122:^
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697:/
349:bp
336:bp
248:bp
235:bp
143:;
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1596:t
1589:v
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