215:
704:
29:
595:"Molecular Modeling of µ Opioid Receptor Ligands with Various Functional Properties: PZM21, SR-17018, Morphine, and Fentanyl-Simulated Interaction Patterns Confronted with Experimental Data"
291:
305:
745:
769:
333:
InChI=1S/C19H18Cl3N3O/c20-13-3-1-12(2-4-13)11-24-7-5-14(6-8-24)25-18-10-16(22)15(21)9-17(18)23-19(25)26/h1-4,9-10,14H,5-8,11H2,(H,23,26)
774:
325:
495:"A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal"
44:
646:"Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain"
126:
764:
194:
738:
789:
368:
155:
644:
Pantouli F, Grim TW, Schmid CL, Acevedo-Canabal A, Kennedy NM, Cameron MD, et al. (December 2020).
784:
731:
352:
210:
61:
683:
475:
493:
Grim TW, Schmid CL, Stahl EL, Pantouli F, Ho JH, Acevedo-Canabal A, et al. (January 2020).
176:
675:
626:
575:
524:
467:
166:
115:
70:
665:
657:
616:
606:
565:
555:
514:
506:
457:
231:
214:
135:
360:
779:
715:
670:
645:
621:
594:
570:
543:
542:
Azevedo Neto J, Costanzini A, De
Giorgio R, Lambert DG, Ruzza C, Calò G (August 2020).
519:
494:
372:
95:
758:
687:
661:
479:
711:
399:
384:
462:
446:"Molecular recognition of morphine and fentanyl by the human μ-opioid receptor"
445:
611:
560:
510:
267:
106:
394:
389:
364:
356:
679:
630:
579:
528:
471:
444:
Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, et al. (November 2022).
703:
593:
Podlewska S, Bugno R, Kudla L, Bojarski AJ, Przewlocki R (October 2020).
544:"Biased versus Partial Agonism in the Search for Safer Opioid Analgesics"
414:
409:
20:
419:
81:
424:
146:
28:
404:
290:
281:
182:
199:
719:
313:
C1CN(CCC1N2C3=CC(=C(C=C3NC2=O)Cl)Cl)CC4=CC=C(C=C4)Cl
52:
5,6-dichloro-3-piperidin-4-yl]-1H-benzimidazol-2-one
279:
266:
230:
225:
193:
165:
145:
125:
105:
80:
60:
35:
351:is a drug which acts as a biased agonist at the
94:
69:
739:
8:
19:
363:recruitment. In animal studies it produces
746:
732:
213:
114:
27:
669:
620:
610:
569:
559:
518:
461:
134:
436:
330:
310:
209:
49:
18:
175:
154:
7:
700:
698:
181:
85:
355:, selective for activation of the
14:
702:
662:10.1016/j.neuropharm.2020.108439
254:
248:
242:
338:Key:LAGUDYUGRSQDKS-UHFFFAOYSA-N
260:
236:
1:
718:. You can help Knowledge by
770:Mu-opioid receptor agonists
375:than conventional opioids.
806:
697:
463:10.1016/j.cell.2022.09.041
226:Chemical and physical data
612:10.3390/molecules25204636
561:10.3390/molecules25173870
511:10.1038/s41386-019-0491-8
321:
301:
40:
26:
775:4-Chlorophenyl compounds
359:signalling pathway over
499:Neuropsychopharmacology
714:-related article is a
369:respiratory depression
367:effects but with less
456:(23): 4361–4375.e19.
371:and development of
23:
765:Pharmacology stubs
727:
726:
650:Neuropharmacology
353:μ-opioid receptor
346:
345:
292:Interactive image
195:CompTox Dashboard
16:Chemical compound
797:
748:
741:
734:
706:
699:
692:
691:
673:
641:
635:
634:
624:
614:
590:
584:
583:
573:
563:
539:
533:
532:
522:
490:
484:
483:
465:
441:
294:
274:
262:
256:
250:
244:
238:
218:
217:
203:
201:
185:
179:
158:
138:
118:
98:
88:
87:
73:
31:
24:
22:
805:
804:
800:
799:
798:
796:
795:
794:
755:
754:
753:
752:
696:
695:
643:
642:
638:
592:
591:
587:
541:
540:
536:
492:
491:
487:
443:
442:
438:
433:
381:
342:
339:
334:
329:
328:
317:
314:
309:
308:
297:
272:
259:
253:
247:
241:
221:
211:DTXSID101336689
197:
189:
161:
141:
121:
101:
84:
76:
56:
53:
48:
47:
17:
12:
11:
5:
803:
801:
793:
792:
790:Benzimidazoles
787:
782:
777:
772:
767:
757:
756:
751:
750:
743:
736:
728:
725:
724:
707:
694:
693:
636:
585:
534:
505:(2): 416–425.
485:
435:
434:
432:
429:
428:
427:
422:
417:
412:
407:
402:
397:
392:
387:
380:
377:
344:
343:
341:
340:
337:
335:
332:
324:
323:
322:
319:
318:
316:
315:
312:
304:
303:
302:
299:
298:
296:
295:
287:
285:
277:
276:
270:
264:
263:
257:
251:
245:
239:
234:
228:
227:
223:
222:
220:
219:
206:
204:
191:
190:
188:
187:
171:
169:
163:
162:
160:
159:
151:
149:
143:
142:
140:
139:
131:
129:
123:
122:
120:
119:
111:
109:
103:
102:
100:
99:
91:
89:
78:
77:
75:
74:
66:
64:
58:
57:
55:
54:
51:
43:
42:
41:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
802:
791:
788:
786:
783:
781:
778:
776:
773:
771:
768:
766:
763:
762:
760:
749:
744:
742:
737:
735:
730:
729:
723:
721:
717:
713:
708:
705:
701:
689:
685:
681:
677:
672:
667:
663:
659:
655:
651:
647:
640:
637:
632:
628:
623:
618:
613:
608:
604:
600:
596:
589:
586:
581:
577:
572:
567:
562:
557:
553:
549:
545:
538:
535:
530:
526:
521:
516:
512:
508:
504:
500:
496:
489:
486:
481:
477:
473:
469:
464:
459:
455:
451:
447:
440:
437:
430:
426:
423:
421:
418:
416:
413:
411:
408:
406:
403:
401:
398:
396:
393:
391:
388:
386:
383:
382:
378:
376:
374:
370:
366:
362:
358:
354:
350:
336:
331:
327:
320:
311:
307:
300:
293:
289:
288:
286:
283:
278:
271:
269:
265:
235:
233:
229:
224:
216:
212:
208:
207:
205:
196:
192:
184:
183:RCSB PDB
178:
173:
172:
170:
168:
164:
157:
156:ChEMBL4452384
153:
152:
150:
148:
144:
137:
133:
132:
130:
128:
124:
117:
113:
112:
110:
108:
104:
97:
93:
92:
90:
83:
79:
72:
68:
67:
65:
63:
59:
50:
46:
39:
34:
30:
25:
720:expanding it
712:pharmacology
709:
653:
649:
639:
605:(20): 4636.
602:
598:
588:
554:(17): 3870.
551:
547:
537:
502:
498:
488:
453:
449:
439:
361:β-arrestin 2
348:
347:
71:2134602-45-0
785:Piperidines
400:Oliceridine
385:Bezitramide
275: g·mol
36:Identifiers
759:Categories
656:: 108439.
431:References
280:3D model (
268:Molar mass
167:PDB ligand
136:2M8P7UAW4W
107:ChemSpider
62:CAS Number
45:IUPAC name
688:229306872
599:Molecules
548:Molecules
480:253426623
395:J-113,397
390:Brorphine
373:tolerance
365:analgesic
357:G-protein
96:130431397
680:33345829
631:33053718
580:32854452
529:31443104
472:36368306
415:SR-16435
410:SR-14968
379:See also
349:SR-17018
116:67886365
21:SR-17018
671:7887086
622:7594085
571:7504468
520:6901606
420:SHR9352
232:Formula
82:PubChem
686:
678:
668:
629:
619:
578:
568:
527:
517:
478:
470:
425:TRV734
306:SMILES
273:410.72
147:ChEMBL
780:Ureas
710:This
684:S2CID
476:S2CID
405:PZM21
326:InChI
282:JSmol
174:WH9 (
716:stub
676:PMID
627:PMID
576:PMID
525:PMID
468:PMID
450:Cell
177:PDBe
127:UNII
666:PMC
658:doi
654:185
617:PMC
607:doi
566:PMC
556:doi
515:PMC
507:doi
458:doi
454:185
200:EPA
86:CID
761::
682:.
674:.
664:.
652:.
648:.
625:.
615:.
603:25
601:.
597:.
574:.
564:.
552:25
550:.
546:.
523:.
513:.
503:45
501:.
497:.
474:.
466:.
452:.
448:.
249:Cl
246:18
240:19
180:,
747:e
740:t
733:v
722:.
690:.
660::
633:.
609::
582:.
558::
531:.
509::
482:.
460::
284:)
261:O
258:3
255:N
252:3
243:H
237:C
202:)
198:(
186:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
