242:
219:
116:
141:
248:
147:
1963:
1983:
1454:
255:
154:
1387:
1421:
722:
703:
77:
1564:
2057:
2028:
1103:
1085:
2047:
1434:
1430:
1017:
1649:
1380:
241:
922:
1682:
1522:
1417:
929:
218:
1121:
1072:
1051:
1482:
1439:
1373:
1838:
1068:
140:
115:
1517:
1953:
1047:
1644:
1477:
57:
1507:
254:
153:
1639:
1527:
1487:
247:
146:
1823:
1400:
2021:
1939:
1926:
1913:
1900:
1887:
1874:
1861:
1595:
1581:
1537:
1464:
1449:
1413:
1833:
1289:"SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder"
1787:
1730:
1404:
767:
65:
1735:
1549:
748:
1600:
1137:"Novel 5 alpha-steroid reductase (SRD5A3, type-3) is overexpressed in hormone-refractory prostate cancer"
1756:
1675:
1502:
1828:
2014:
1512:
1444:
1247:
129:
44:
1792:
1365:
2052:
1725:
1590:
1176:
89:
1236:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
905:
884:
858:
837:
1617:
1492:
1353:
1318:
1275:
1222:
1201:"Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones"
1168:
37:
1998:
1771:
1766:
1740:
1668:
1497:
1343:
1308:
1300:
1265:
1255:
1212:
1158:
1148:
1022:
334:
265:
209:
164:
85:
1818:
1802:
1715:
309:
1000:
1251:
1163:
1136:
1135:
Uemura M, Tamura K, Chung S, Honma S, Okuyama A, Nakamura Y, Nakagawa H (January 2008).
1967:
1856:
1797:
1396:
1313:
1288:
1270:
1235:
637:
632:
627:
622:
617:
612:
607:
602:
586:
581:
576:
571:
566:
550:
545:
540:
535:
530:
525:
2041:
1761:
1720:
1153:
546:
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
512:
1180:
69:
1994:
1710:
327:
106:
93:
1934:
1869:
1705:
1108:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1090:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1962:
1304:
410:
1012:
226:
123:
73:
1908:
1882:
1332:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
667:
470:
348:
293:
280:
192:
179:
81:
1357:
1322:
1279:
1260:
1226:
1172:
969:
964:
1217:
1200:
953:
812:
793:
1541:
779:
734:
1921:
1691:
1627:
1622:
1605:
1468:
989:
937:
689:
48:, CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1, steroid 5 alpha-reductase 3
1982:
1348:
1331:
1895:
1610:
652:
648:
1990:
1569:
1559:
1554:
996:
61:
1664:
1369:
526:
oxidoreductase activity, acting on the CH-CH group of donors
1234:
Strausberg RL, Feingold EA, Grouse LH, et al. (2002).
1660:
317:
2002:
1951:
482:
1455:
Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase
1287:
Cantagrel V, Lefeber DJ, Ng BG, et al. (2010).
633:
dolichol-linked oligosaccharide biosynthetic process
1847:
1811:
1780:
1749:
1698:
1580:
1536:
1463:
1412:
898:
877:
851:
830:
1330:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
1064:
1062:
1060:
1043:
1041:
1039:
264:
163:
16:Protein-coding gene in the species Homo sapiens
1069:GRCm38: Ensembl release 89: ENSMUSG00000029233
1025:, a syndrome caused by a mutation in this gene
541:3-oxo-5-alpha-steroid 4-dehydrogenase activity
2022:
1676:
1381:
8:
1048:GRCh38: Ensembl release 89: ENSG00000128039
2029:
2015:
1683:
1669:
1661:
1388:
1374:
1366:
1122:"Entrez Gene: steroid 5 alpha-reductase 3"
663:
508:
305:
204:
101:
1347:
1312:
1269:
1259:
1216:
1162:
1152:
628:dolichyl diphosphate biosynthetic process
1958:
1035:
986:3-oxo-5-alpha-steroid 4-dehydrogenase 3
531:cholestenone 5-alpha-reductase activity
18:
269:
230:
225:
168:
127:
122:
7:
1979:
1977:
1431:Enoyl-acyl carrier protein reductase
1018:Congenital disorder of glycosylation
1650:3-oxo-5beta-steroid 4-dehydrogenase
1645:Isovaleryl coenzyme A dehydrogenase
2001:. You can help Knowledge (XXG) by
895:
874:
848:
827:
803:
784:
758:
739:
713:
694:
487:
405:
343:
322:
14:
1523:Pyrroloquinoline-quinone synthase
992:that in humans is encoded by the
1981:
1961:
1154:10.1111/j.1349-7006.2007.00656.x
253:
246:
240:
217:
152:
145:
139:
114:
1483:Coproporphyrinogen III oxidase
1440:7-Dehydrocholesterol reductase
999:. It is one of three forms of
577:endoplasmic reticulum membrane
572:integral component of membrane
471:More reference expression data
367:olfactory zone of nasal mucosa
1:
2058:Human chromosome 4 gene stubs
1518:Tryptophan alpha,beta-oxidase
638:dolichol biosynthetic process
613:androgen biosynthetic process
551:polyprenol reductase activity
238:
137:
1478:Dihydroorotate dehydrogenase
1240:Proc. Natl. Acad. Sci. U.S.A
608:polyprenol catabolic process
2048:Genes on human chromosome 4
1508:Tetrahydroberberine oxidase
1199:Payne AH, Hales DB (2004).
982:Steroid 5-alpha-reductase 3
2074:
1976:
1640:Glutaryl-CoA dehydrogenase
1528:L-galactonolactone oxidase
1488:Protoporphyrinogen oxidase
1305:10.1016/j.cell.2010.06.001
623:dolichol metabolic process
1839:Michaelis–Menten kinetics
1596:Butyryl-CoA dehydrogenase
1450:2,4 Dienoyl-CoA reductase
1104:"Mouse PubMed Reference:"
1086:"Human PubMed Reference:"
968:
963:
959:
952:
936:
917:
902:
881:
870:
855:
834:
823:
810:
806:
791:
787:
778:
765:
761:
746:
742:
733:
720:
716:
701:
697:
688:
673:
666:
662:
646:
511:
507:
495:
490:
481:
468:
417:
408:
395:epithelium of nasopharynx
355:
346:
316:
308:
304:
287:
274:
237:
216:
207:
203:
186:
173:
136:
113:
104:
100:
55:
52:
42:
35:
30:
26:
21:
1731:Diffusion-limited enzyme
1550:Succinate dehydrogenase
923:Chr 4: 55.35 – 55.37 Mb
536:oxidoreductase activity
453:external carotid artery
441:internal carotid artery
1601:Acyl CoA dehydrogenase
1261:10.1073/pnas.242603899
930:Chr 5: 76.29 – 76.3 Mb
421:lumbar spinal ganglion
1824:Eadie–Hofstee diagram
1757:Allosteric regulation
1503:Dihydrouracil oxidase
1401:CH–CH oxidoreductases
618:protein glycosylation
587:endoplasmic reticulum
457:stroma of bone marrow
359:palpebral conjunctiva
1834:Lineweaver–Burk plot
1513:Secologanin synthase
1445:Biliverdin reductase
1218:10.1210/er.2003-0030
232:Chromosome 5 (mouse)
130:Chromosome 4 (human)
1435:Enoyl ACP reductase
1252:2002PNAS...9916899M
383:gingival epithelium
371:mucosa of esophagus
1989:This article on a
1793:Enzyme superfamily
1726:Enzyme promiscuity
1591:Fumarate reductase
768:ENSMUSG00000029233
596:Biological process
560:Cellular component
519:Molecular function
94:SRD5A3 - orthologs
2010:
2009:
1949:
1948:
1658:
1657:
1584:: Other acceptors
1493:Bilirubin oxidase
1246:(26): 16899–903.
979:
978:
975:
974:
948:
947:
913:
912:
892:
891:
866:
865:
845:
844:
819:
818:
800:
799:
774:
773:
755:
754:
729:
728:
710:
709:
658:
657:
503:
502:
499:
498:
477:
476:
464:
463:
402:
401:
300:
299:
199:
198:
2065:
2031:
2024:
2017:
1985:
1978:
1966:
1965:
1957:
1829:Hanes–Woolf plot
1772:Enzyme activator
1767:Enzyme inhibitor
1741:Enzyme catalysis
1685:
1678:
1671:
1662:
1498:Acyl-CoA oxidase
1390:
1383:
1376:
1367:
1361:
1351:
1326:
1316:
1283:
1273:
1263:
1230:
1220:
1185:
1184:
1166:
1156:
1132:
1126:
1125:
1118:
1112:
1111:
1100:
1094:
1093:
1082:
1076:
1066:
1055:
1045:
1023:Kahrizi syndrome
984:, also known as
961:
960:
932:
925:
908:
896:
887:
875:
871:RefSeq (protein)
861:
849:
840:
828:
804:
785:
759:
740:
714:
695:
664:
603:lipid metabolism
509:
488:
473:
429:secondary oocyte
413:
411:Top expressed in
406:
375:body of pancreas
351:
349:Top expressed in
344:
323:
306:
296:
283:
272:
257:
250:
244:
233:
221:
205:
195:
182:
171:
156:
149:
143:
132:
118:
102:
96:
47:
40:
19:
2073:
2072:
2068:
2067:
2066:
2064:
2063:
2062:
2038:
2037:
2036:
2035:
1974:
1972:
1960:
1952:
1950:
1945:
1857:Oxidoreductases
1843:
1819:Enzyme kinetics
1807:
1803:List of enzymes
1776:
1745:
1716:Catalytic triad
1694:
1689:
1659:
1654:
1576:
1532:
1459:
1408:
1397:Oxidoreductases
1394:
1364:
1329:
1286:
1233:
1198:
1194:
1192:Further reading
1189:
1188:
1134:
1133:
1129:
1120:
1119:
1115:
1102:
1101:
1097:
1084:
1083:
1079:
1067:
1058:
1046:
1037:
1032:
1009:
970:View/Edit Mouse
965:View/Edit Human
928:
921:
918:Location (UCSC)
904:
883:
857:
836:
749:ENSG00000128039
642:
591:
555:
469:
460:
455:
451:
447:
443:
439:
435:
431:
427:
423:
409:
398:
393:
389:
385:
381:
377:
373:
369:
365:
361:
347:
291:
278:
270:
260:
259:
258:
251:
231:
208:Gene location (
190:
177:
169:
159:
158:
157:
150:
128:
105:Gene location (
56:
43:
36:
17:
12:
11:
5:
2071:
2069:
2061:
2060:
2055:
2050:
2040:
2039:
2034:
2033:
2026:
2019:
2011:
2008:
2007:
1986:
1971:
1970:
1947:
1946:
1944:
1943:
1930:
1917:
1904:
1891:
1878:
1865:
1851:
1849:
1845:
1844:
1842:
1841:
1836:
1831:
1826:
1821:
1815:
1813:
1809:
1808:
1806:
1805:
1800:
1795:
1790:
1784:
1782:
1781:Classification
1778:
1777:
1775:
1774:
1769:
1764:
1759:
1753:
1751:
1747:
1746:
1744:
1743:
1738:
1733:
1728:
1723:
1718:
1713:
1708:
1702:
1700:
1696:
1695:
1690:
1688:
1687:
1680:
1673:
1665:
1656:
1655:
1653:
1652:
1647:
1642:
1637:
1636:
1635:
1630:
1625:
1615:
1614:
1613:
1608:
1598:
1593:
1587:
1585:
1578:
1577:
1575:
1574:
1573:
1572:
1567:
1562:
1557:
1546:
1544:
1534:
1533:
1531:
1530:
1525:
1520:
1515:
1510:
1505:
1500:
1495:
1490:
1485:
1480:
1474:
1472:
1461:
1460:
1458:
1457:
1452:
1447:
1442:
1437:
1427:
1425:
1410:
1409:
1395:
1393:
1392:
1385:
1378:
1370:
1363:
1362:
1349:10.1038/ng1285
1327:
1284:
1231:
1195:
1193:
1190:
1187:
1186:
1127:
1113:
1095:
1077:
1056:
1034:
1033:
1031:
1028:
1027:
1026:
1020:
1015:
1008:
1005:
977:
976:
973:
972:
967:
957:
956:
950:
949:
946:
945:
943:
941:
934:
933:
926:
919:
915:
914:
911:
910:
900:
899:
893:
890:
889:
879:
878:
872:
868:
867:
864:
863:
853:
852:
846:
843:
842:
832:
831:
825:
821:
820:
817:
816:
808:
807:
801:
798:
797:
789:
788:
782:
776:
775:
772:
771:
763:
762:
756:
753:
752:
744:
743:
737:
731:
730:
727:
726:
718:
717:
711:
708:
707:
699:
698:
692:
686:
685:
680:
675:
671:
670:
660:
659:
656:
655:
644:
643:
641:
640:
635:
630:
625:
620:
615:
610:
605:
599:
597:
593:
592:
590:
589:
584:
579:
574:
569:
563:
561:
557:
556:
554:
553:
548:
543:
538:
533:
528:
522:
520:
516:
515:
505:
504:
501:
500:
497:
496:
493:
492:
485:
479:
478:
475:
474:
466:
465:
462:
461:
459:
458:
454:
450:
446:
442:
438:
437:primary oocyte
434:
430:
426:
422:
418:
415:
414:
403:
400:
399:
397:
396:
392:
388:
384:
380:
376:
372:
368:
364:
360:
356:
353:
352:
340:
339:
331:
320:
314:
313:
310:RNA expression
302:
301:
298:
297:
289:
285:
284:
276:
273:
268:
262:
261:
252:
245:
239:
235:
234:
229:
223:
222:
214:
213:
201:
200:
197:
196:
188:
184:
183:
175:
172:
167:
161:
160:
151:
144:
138:
134:
133:
126:
120:
119:
111:
110:
98:
97:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2070:
2059:
2056:
2054:
2051:
2049:
2046:
2045:
2043:
2032:
2027:
2025:
2020:
2018:
2013:
2012:
2006:
2004:
2000:
1996:
1992:
1987:
1984:
1980:
1975:
1969:
1964:
1959:
1955:
1941:
1937:
1936:
1931:
1928:
1924:
1923:
1918:
1915:
1911:
1910:
1905:
1902:
1898:
1897:
1892:
1889:
1885:
1884:
1879:
1876:
1872:
1871:
1866:
1863:
1859:
1858:
1853:
1852:
1850:
1846:
1840:
1837:
1835:
1832:
1830:
1827:
1825:
1822:
1820:
1817:
1816:
1814:
1810:
1804:
1801:
1799:
1798:Enzyme family
1796:
1794:
1791:
1789:
1786:
1785:
1783:
1779:
1773:
1770:
1768:
1765:
1763:
1762:Cooperativity
1760:
1758:
1755:
1754:
1752:
1748:
1742:
1739:
1737:
1734:
1732:
1729:
1727:
1724:
1722:
1721:Oxyanion hole
1719:
1717:
1714:
1712:
1709:
1707:
1704:
1703:
1701:
1697:
1693:
1686:
1681:
1679:
1674:
1672:
1667:
1666:
1663:
1651:
1648:
1646:
1643:
1641:
1638:
1634:
1631:
1629:
1626:
1624:
1621:
1620:
1619:
1616:
1612:
1609:
1607:
1604:
1603:
1602:
1599:
1597:
1594:
1592:
1589:
1588:
1586:
1583:
1579:
1571:
1568:
1566:
1563:
1561:
1558:
1556:
1553:
1552:
1551:
1548:
1547:
1545:
1543:
1539:
1535:
1529:
1526:
1524:
1521:
1519:
1516:
1514:
1511:
1509:
1506:
1504:
1501:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1479:
1476:
1475:
1473:
1470:
1466:
1462:
1456:
1453:
1451:
1448:
1446:
1443:
1441:
1438:
1436:
1432:
1429:
1428:
1426:
1423:
1419:
1415:
1411:
1406:
1402:
1398:
1391:
1386:
1384:
1379:
1377:
1372:
1371:
1368:
1359:
1355:
1350:
1345:
1341:
1337:
1333:
1328:
1324:
1320:
1315:
1310:
1306:
1302:
1299:(2): 203–17.
1298:
1294:
1290:
1285:
1281:
1277:
1272:
1267:
1262:
1257:
1253:
1249:
1245:
1241:
1237:
1232:
1228:
1224:
1219:
1214:
1211:(6): 947–70.
1210:
1206:
1202:
1197:
1196:
1191:
1182:
1178:
1174:
1170:
1165:
1160:
1155:
1150:
1146:
1142:
1138:
1131:
1128:
1123:
1117:
1114:
1109:
1105:
1099:
1096:
1091:
1087:
1081:
1078:
1074:
1070:
1065:
1063:
1061:
1057:
1053:
1049:
1044:
1042:
1040:
1036:
1029:
1024:
1021:
1019:
1016:
1014:
1011:
1010:
1006:
1004:
1002:
998:
995:
991:
987:
983:
971:
966:
962:
958:
955:
951:
944:
942:
939:
935:
931:
927:
924:
920:
916:
909:
907:
901:
897:
894:
888:
886:
880:
876:
873:
869:
862:
860:
854:
850:
847:
841:
839:
833:
829:
826:
824:RefSeq (mRNA)
822:
815:
814:
809:
805:
802:
796:
795:
790:
786:
783:
781:
777:
770:
769:
764:
760:
757:
751:
750:
745:
741:
738:
736:
732:
725:
724:
719:
715:
712:
706:
705:
700:
696:
693:
691:
687:
684:
681:
679:
676:
672:
669:
665:
661:
654:
650:
645:
639:
636:
634:
631:
629:
626:
624:
621:
619:
616:
614:
611:
609:
606:
604:
601:
600:
598:
595:
594:
588:
585:
583:
580:
578:
575:
573:
570:
568:
565:
564:
562:
559:
558:
552:
549:
547:
544:
542:
539:
537:
534:
532:
529:
527:
524:
523:
521:
518:
517:
514:
513:Gene ontology
510:
506:
494:
489:
486:
484:
480:
472:
467:
456:
452:
448:
444:
440:
436:
432:
428:
424:
420:
419:
416:
412:
407:
404:
394:
390:
386:
382:
379:skin of thigh
378:
374:
370:
366:
362:
358:
357:
354:
350:
345:
342:
341:
338:
336:
332:
330:
329:
325:
324:
321:
319:
315:
311:
307:
303:
295:
290:
286:
282:
277:
271:5|5 C3.3
267:
263:
256:
249:
243:
236:
228:
224:
220:
215:
211:
206:
202:
194:
189:
185:
181:
176:
166:
162:
155:
148:
142:
135:
131:
125:
121:
117:
112:
108:
103:
99:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
2003:expanding it
1995:chromosome 4
1988:
1973:
1935:Translocases
1932:
1919:
1906:
1893:
1880:
1870:Transferases
1867:
1854:
1711:Binding site
1632:
1618:5α-reductase
1339:
1335:
1296:
1292:
1243:
1239:
1208:
1204:
1144:
1140:
1130:
1116:
1107:
1098:
1089:
1080:
1001:5α-reductase
993:
985:
981:
980:
903:
882:
856:
835:
811:
792:
766:
747:
721:
702:
682:
677:
333:
326:
53:External IDs
1706:Active site
1342:(1): 40–5.
1205:Endocr. Rev
1147:(1): 81–6.
425:granulocyte
363:gallbladder
292:76,303,351
279:76,288,118
191:55,373,100
178:55,346,213
31:Identifiers
2042:Categories
1909:Isomerases
1883:Hydrolases
1750:Regulation
1336:Nat. Genet
1141:Cancer Sci
1075:, May 2017
1054:, May 2017
1030:References
1013:SRD5A3-CDG
391:C1 segment
337:(ortholog)
74:HomoloGene
2053:EC 1.3.99
1993:on human
1788:EC number
906:NP_065636
885:NP_078868
859:NM_020611
838:NM_024592
668:Orthologs
567:cytoplasm
82:GeneCards
1812:Kinetics
1736:Cofactor
1699:Activity
1471:acceptor
1424:acceptor
1358:14702039
1323:20637498
1280:12477932
1227:15583024
1181:51733620
1173:17986282
1164:11158902
1071:–
1050:–
1007:See also
988:, is an
954:Wikidata
647:Sources:
582:membrane
445:yolk sac
1968:Biology
1922:Ligases
1692:Enzymes
1542:Quinone
1314:2940322
1248:Bibcode
1073:Ensembl
1052:Ensembl
780:UniProt
735:Ensembl
674:Species
653:QuickGO
312:pattern
70:1930252
38:Aliases
1954:Portal
1896:Lyases
1633:SRD5A3
1628:SRD5A2
1623:SRD5A1
1606:ACADSB
1582:1.3.99
1469:Oxygen
1356:
1321:
1311:
1278:
1271:139241
1268:
1225:
1179:
1171:
1161:
994:SRD5A3
990:enzyme
940:search
938:PubMed
813:Q9WUP4
794:Q9H8P0
690:Entrez
483:BioGPS
433:zygote
86:SRD5A3
62:611715
45:SRD5A3
22:SRD5A3
1997:is a
1848:Types
1611:ACADS
1538:1.3.5
1465:1.3.3
1414:1.3.1
1177:S2CID
723:57357
704:79644
683:Mouse
678:Human
649:Amigo
387:gonad
335:Mouse
328:Human
275:Start
210:Mouse
174:Start
107:Human
78:41385
1999:stub
1991:gene
1940:list
1933:EC7
1927:list
1920:EC6
1914:list
1907:EC5
1901:list
1894:EC4
1888:list
1881:EC3
1875:list
1868:EC2
1862:list
1855:EC1
1570:SDHD
1565:SDHC
1560:SDHB
1555:SDHA
1422:NADP
1407:1.3)
1354:PMID
1319:PMID
1293:Cell
1276:PMID
1223:PMID
1169:PMID
997:gene
318:Bgee
266:Band
227:Chr.
170:4q12
165:Band
124:Chr.
58:OMIM
1418:NAD
1344:doi
1309:PMC
1301:doi
1297:142
1266:PMC
1256:doi
1213:doi
1159:PMC
1149:doi
491:n/a
449:lip
288:End
187:End
90:OMA
66:MGI
2044::
1540::
1467::
1416::
1405:EC
1399::
1352:.
1340:36
1338:.
1334:.
1317:.
1307:.
1295:.
1291:.
1274:.
1264:.
1254:.
1244:99
1242:.
1238:.
1221:.
1209:25
1207:.
1203:.
1175:.
1167:.
1157:.
1145:99
1143:.
1139:.
1106:.
1088:.
1059:^
1038:^
1003:.
651:/
294:bp
281:bp
193:bp
180:bp
88:;
84::
80:;
76::
72:;
68::
64:;
60::
2030:e
2023:t
2016:v
2005:.
1956::
1942:)
1938:(
1929:)
1925:(
1916:)
1912:(
1903:)
1899:(
1890:)
1886:(
1877:)
1873:(
1864:)
1860:(
1684:e
1677:t
1670:v
1433:/
1420:/
1403:(
1389:e
1382:t
1375:v
1360:.
1346::
1325:.
1303::
1282:.
1258::
1250::
1229:.
1215::
1183:.
1151::
1124:.
1110:.
1092:.
212:)
109:)
92::
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