29:
310:
287:
184:
209:
575:
561:
1236:. Cohesion folds by DNA loop extrusion and this cohesion consists of SMC1, SMC3, RAD21, and either STAG1 or STAG2. SA2 interacts with a ring-like structure composed of SMC1A, SMC3, and RAD21, to form the core of the cohesin complex. The ring-like structure binds chromosomes together until degradation of the cohesin complex is finished during cell division. This allows for the replicated chromosomes to separate into two new cells. Another role of
568:
316:
215:
1287:
can result in one third of non-muscle-invasive bladder cancer to have complete loss of SA2 protein. The loss of this protein has been shown to indicate the prognosis of disease and survival. it has been shown there was a delay in maturation of oligodendrocytes and transcription of myelination-related
55:
1288:
genes was reduced. Cohesion is needed in proper gene expression in specific cells and an implication the myelination is affected in a negative way. Mutations of STAG2 occur frequently in many cancers, which indicates this protein has a role in cancer. Mutations of the
1391:
Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, et al. (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs".
1911:
Gokce-Samar Z, de
Bellescize J, Arzimanoglou A, Putoux A, Chatron N, Lesca G, Portes VD (December 2022). "STAG2 microduplication in a patient with eyelid myoclonia and absences and a review of EMA-related reported genes".
1264:, is an X-linked neurodevelopmental disorder that results in delayed development and intellectual disability associated with abnormal behavior and dysmorphic facial features, and the whole STAG2 gene can develop
1868:
Turchi G, Bernardo P, Consales A, Bilo L, Coppola A (April 2020). "Xq25 microduplication syndrome: a further contribution to its definition. A case report and review of the literature".
323:
222:
1159:
813:
794:
145:
1957:"STAG2 Protein Expression in Non-muscle-invasive Bladder Cancer: Associations with Sex, Genomic and Transcriptomic Changes, and Clinical Outcomes"
1373:
1355:
2010:
52:
1077:
309:
1084:
286:
1427:
1167:
1342:
1321:
1256:
is the subunit where the most variants have been reported in cancer. This is thought to be because this gene is located in the
28:
1737:"STAG2 expression is associated with adverse survival outcomes and regulates cell phenotype in muscle-invasive bladder cancer"
1338:
208:
183:
1317:
125:
1686:"Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells"
1229:
322:
221:
315:
214:
1819:"Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2"
1492:
Mehta GD, Kumar R, Srivastava S, Ghosh SK (August 2013). "Cohesin: functions beyond sister chromatid cohesion".
1163:
858:
133:
1272:
839:
1296:
has been found to be the only gene of 12 that is mutated significantly in at least four types of cancers.
1735:
Athans S, Krishnan N, Ramakrishnan S, Cortes Gomez E, Lage-Vickers S, Rak M, et al. (October 2022).
197:
112:
1060:
1052:
1048:
1027:
1013:
1009:
1005:
1001:
981:
973:
969:
948:
934:
930:
926:
922:
1955:
Gordon NS, Humayun-Zakaria N, Goel A, Abbotts B, Zeegers MP, Cheng KK, et al. (April 2022).
1937:
1893:
1774:
1663:
1517:
157:
1056:
1017:
977:
938:
1986:
1929:
1885:
1850:
1766:
1717:
1655:
1620:
1566:
1509:
1474:
1409:
574:
560:
105:
45:
1976:
1968:
1921:
1877:
1840:
1830:
1756:
1748:
1707:
1697:
1647:
1610:
1600:
1556:
1548:
1501:
1464:
1454:
1401:
402:
333:
277:
232:
1793:
567:
153:
1225:
377:
1261:
1981:
1956:
1845:
1818:
1761:
1736:
1712:
1685:
1615:
1588:
1561:
1536:
1469:
1442:
1268:
1240:
is to encode the stromal antigen 2 protein, which is involved in chromatin organization
1405:
728:
723:
718:
713:
708:
703:
698:
682:
677:
672:
667:
662:
657:
652:
647:
642:
637:
621:
616:
2004:
1941:
1897:
1778:
603:
1684:
Arruda NL, Carico ZM, Justice M, Liu YF, Zhou J, Stefan HC, Dowen JM (August 2020).
1667:
1521:
137:
1537:"Characterization of vertebrate cohesin complexes and their regulation in prophase"
1257:
395:
174:
1752:
1505:
1881:
1835:
161:
1972:
1459:
1378:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1360:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1925:
1702:
478:
1638:
Losada A (June 2014). "Cohesin in cancer: chromosome segregation and beyond".
294:
191:
141:
1817:
Kim JS, He X, Orr B, Wutz G, Hill V, Peters JM, et al. (February 2016).
1589:"STAG2 promotes the myelination transcriptional program in oligodendrocytes"
1221:
758:
538:
416:
361:
348:
260:
247:
149:
1990:
1933:
1889:
1854:
1770:
1721:
1659:
1624:
1570:
1513:
1478:
1552:
1413:
1208:
is frequently mutated in a range of cancers and several other disorders.
1124:
1119:
1535:
Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000).
1108:
903:
884:
1605:
1217:
1187:
1155:
1144:
870:
825:
82:
78:
74:
1244:
transcription, DNA repair and control of downstream gene expression.
1092:
780:
116:, SA-2, SA2, SCC3B, bA517O1.1, stromal antigen 2, NEDXCF, MKMS, HPE13
1651:
1587:
Cheng N, Li G, Kanchwala M, Evers BM, Xing C, Yu H (August 2022).
1292:
gene are frequently seen in multiple adult and pediatric cancers.
1233:
1199:
1191:
1183:
1179:
1175:
743:
739:
1195:
1171:
1151:
583:
129:
1260:, therefore only one mutation is needed to inactivate it.
385:
1275:(EMA), and was formally named Jeavons syndrome (JS).
550:
1041:
1000:
962:
921:
1334:
1332:
1330:
1313:
1311:
1309:
332:
231:
1339:GRCm38: Ensembl release 89: ENSMUSG00000025862
1271:. This has all the symptoms of epilepsy with
1220:, which is a structure that holds the sister
8:
709:negative regulation of DNA endoreduplication
1447:Cold Spring Harbor Perspectives in Medicine
1318:GRCh38: Ensembl release 89: ENSG00000101972
997:
918:
754:
599:
373:
272:
169:
63:
1980:
1844:
1834:
1760:
1711:
1701:
1614:
1604:
1560:
1468:
1458:
1441:De Koninck M, Losada A (December 2016).
1170:. In somatic cells cohesin is formed of
1305:
1428:"Entrez Gene: STAG2 stromal antigen 2"
729:regulation of mitotic spindle assembly
18:
1679:
1677:
1582:
1580:
337:
298:
293:
236:
195:
190:
7:
1914:European Journal of Medical Genetics
489:vestibular membrane of cochlear duct
1038:
959:
894:
875:
849:
830:
804:
785:
555:
473:
411:
390:
14:
1147:that in humans is encoded by the
573:
566:
559:
321:
314:
308:
285:
220:
213:
207:
182:
27:
1741:Cancer Research Communications
663:chromosome, centromeric region
584:More reference expression data
539:More reference expression data
1:
1961:European Urology Open Science
1753:10.1158/2767-9764.CRC-22-0155
1506:10.1016/j.febslet.2013.06.035
1443:"Cohesin Mutations in Cancer"
1406:10.1016/S0378-1119(97)00121-2
1273:eyelid myoclonia and absences
1190:, cohesin is formed of SMC3,
525:vestibular sensory epithelium
306:
205:
16:Protein-coding gene in humans
1882:10.1097/mcd.0000000000000303
1836:10.1371/journal.pgen.1005865
521:Epithelium of choroid plexus
439:Epithelium of choroid plexus
2011:Genes on human chromosome X
1973:10.1016/j.euros.2022.02.004
1690:Epigenetics & Chromatin
1541:The Journal of Cell Biology
1460:10.1101/cshperspect.a026476
1283:One result of mutations in
1228:. STAG2 has been shown to
2027:
1926:10.1016/j.ejmg.2022.104636
1703:10.1186/s13072-020-00353-9
1154:. SA2 is a subunit of the
509:medial ganglionic eminence
1374:"Mouse PubMed Reference:"
1356:"Human PubMed Reference:"
1262:Xq25 duplication syndrome
1160:sister chromatid cohesion
1123:
1118:
1114:
1107:
1091:
1078:Chr X: 123.96 – 124.42 Mb
1072:
1045:
1024:
993:
966:
945:
914:
901:
897:
882:
878:
869:
856:
852:
837:
833:
824:
811:
807:
792:
788:
779:
764:
757:
753:
737:
724:sister chromatid cohesion
602:
598:
581:
558:
549:
536:
485:
476:
427:mucosa of paranasal sinus
423:
414:
384:
376:
372:
355:
342:
305:
284:
275:
271:
254:
241:
204:
181:
172:
168:
123:
120:
110:
103:
98:
71:
66:
49:
44:
39:
35:
26:
21:
1252:Of the cohesin complex,
1164:homologous recombination
1158:complex which mediates
1085:Chr X: 41.24 – 41.37 Mb
1870:Clinical Dysmorphology
1640:Nature Reviews. Cancer
699:chromosome segregation
501:atrioventricular valve
1794:"STAG2 Gene - COSMIC"
1553:10.1083/jcb.151.4.749
1137:Cohesin subunit SA-2
683:mitotic spindle pole
300:X chromosome (mouse)
198:X chromosome (human)
67:List of PDB id codes
40:Available structures
1798:cancer.sanger.ac.uk
1606:10.7554/eLife.77848
1216:SA2 is part of the
455:epithelium of colon
1186:or SA2 whereas in
859:ENSMUSG00000025862
692:Biological process
631:Cellular component
610:Molecular function
447:lower lobe of lung
1747:(10): 1129–1143.
1500:(15): 2299–2312.
1134:
1133:
1130:
1129:
1103:
1102:
1068:
1067:
1035:
1034:
989:
988:
956:
955:
910:
909:
891:
890:
865:
864:
846:
845:
820:
819:
801:
800:
749:
748:
622:chromatin binding
594:
593:
590:
589:
545:
544:
532:
531:
470:
469:
368:
367:
267:
266:
162:STAG2 - orthologs
94:
93:
90:
89:
50:Ortholog search:
2018:
1995:
1994:
1984:
1952:
1946:
1945:
1908:
1902:
1901:
1865:
1859:
1858:
1848:
1838:
1814:
1808:
1807:
1805:
1804:
1789:
1783:
1782:
1764:
1732:
1726:
1725:
1715:
1705:
1681:
1672:
1671:
1635:
1629:
1628:
1618:
1608:
1584:
1575:
1574:
1564:
1532:
1526:
1525:
1489:
1483:
1482:
1472:
1462:
1438:
1432:
1431:
1424:
1418:
1417:
1388:
1382:
1381:
1370:
1364:
1363:
1352:
1346:
1336:
1325:
1315:
1116:
1115:
1087:
1080:
1063:
1039:
1030:
998:
994:RefSeq (protein)
984:
960:
951:
919:
895:
876:
850:
831:
805:
786:
755:
600:
586:
577:
570:
563:
556:
541:
481:
479:Top expressed in
474:
463:ventricular zone
459:cartilage tissue
451:lactiferous duct
419:
417:Top expressed in
412:
391:
374:
364:
351:
340:
325:
318:
312:
301:
289:
273:
263:
250:
239:
224:
217:
211:
200:
186:
170:
164:
115:
108:
85:
64:
58:
37:
36:
31:
19:
2026:
2025:
2021:
2020:
2019:
2017:
2016:
2015:
2001:
2000:
1999:
1998:
1954:
1953:
1949:
1910:
1909:
1905:
1867:
1866:
1862:
1829:(2): e1005865.
1816:
1815:
1811:
1802:
1800:
1791:
1790:
1786:
1734:
1733:
1729:
1683:
1682:
1675:
1652:10.1038/nrc3743
1637:
1636:
1632:
1586:
1585:
1578:
1534:
1533:
1529:
1491:
1490:
1486:
1453:(12): a026476.
1440:
1439:
1435:
1426:
1425:
1421:
1390:
1389:
1385:
1372:
1371:
1367:
1354:
1353:
1349:
1337:
1328:
1316:
1307:
1302:
1281:
1250:
1226:DNA replication
1224:together after
1218:cohesin complex
1214:
1125:View/Edit Mouse
1120:View/Edit Human
1083:
1076:
1073:Location (UCSC)
1059:
1055:
1051:
1047:
1026:
1020:
1016:
1012:
1008:
1004:
980:
976:
972:
968:
947:
941:
937:
933:
929:
925:
840:ENSG00000101972
733:
687:
673:cohesin complex
626:
617:protein binding
582:
572:
571:
565:
564:
537:
528:
523:
519:
515:
511:
507:
503:
499:
495:
491:
477:
466:
461:
457:
453:
449:
445:
443:trabecular bone
441:
437:
433:
431:Achilles tendon
429:
415:
359:
346:
338:
328:
327:
326:
319:
299:
276:Gene location (
258:
245:
237:
227:
226:
225:
218:
196:
173:Gene location (
124:
111:
104:
73:
51:
17:
12:
11:
5:
2024:
2022:
2014:
2013:
2003:
2002:
1997:
1996:
1947:
1920:(12): 104636.
1903:
1860:
1809:
1784:
1727:
1673:
1646:(6): 389–393.
1630:
1576:
1547:(4): 749–762.
1527:
1484:
1433:
1419:
1400:(2): 151–159.
1383:
1365:
1347:
1326:
1304:
1303:
1301:
1298:
1280:
1277:
1269:encephalopathy
1249:
1246:
1213:
1210:
1132:
1131:
1128:
1127:
1122:
1112:
1111:
1105:
1104:
1101:
1100:
1098:
1096:
1089:
1088:
1081:
1074:
1070:
1069:
1066:
1065:
1043:
1042:
1036:
1033:
1032:
1022:
1021:
995:
991:
990:
987:
986:
964:
963:
957:
954:
953:
943:
942:
916:
912:
911:
908:
907:
899:
898:
892:
889:
888:
880:
879:
873:
867:
866:
863:
862:
854:
853:
847:
844:
843:
835:
834:
828:
822:
821:
818:
817:
809:
808:
802:
799:
798:
790:
789:
783:
777:
776:
771:
766:
762:
761:
751:
750:
747:
746:
735:
734:
732:
731:
726:
721:
716:
711:
706:
701:
695:
693:
689:
688:
686:
685:
680:
678:nuclear matrix
675:
670:
665:
660:
655:
650:
645:
640:
634:
632:
628:
627:
625:
624:
619:
613:
611:
607:
606:
596:
595:
592:
591:
588:
587:
579:
578:
553:
547:
546:
543:
542:
534:
533:
530:
529:
527:
526:
522:
518:
514:
513:lacrimal gland
510:
506:
502:
498:
494:
493:left lung lobe
490:
486:
483:
482:
471:
468:
467:
465:
464:
460:
456:
452:
448:
444:
440:
436:
432:
428:
424:
421:
420:
408:
407:
399:
388:
382:
381:
378:RNA expression
370:
369:
366:
365:
357:
353:
352:
344:
341:
336:
330:
329:
320:
313:
307:
303:
302:
297:
291:
290:
282:
281:
269:
268:
265:
264:
256:
252:
251:
243:
240:
235:
229:
228:
219:
212:
206:
202:
201:
194:
188:
187:
179:
178:
166:
165:
122:
118:
117:
109:
101:
100:
96:
95:
92:
91:
88:
87:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2023:
2012:
2009:
2008:
2006:
1992:
1988:
1983:
1978:
1974:
1970:
1966:
1962:
1958:
1951:
1948:
1943:
1939:
1935:
1931:
1927:
1923:
1919:
1915:
1907:
1904:
1899:
1895:
1891:
1887:
1883:
1879:
1875:
1871:
1864:
1861:
1856:
1852:
1847:
1842:
1837:
1832:
1828:
1824:
1823:PLOS Genetics
1820:
1813:
1810:
1799:
1795:
1788:
1785:
1780:
1776:
1772:
1768:
1763:
1758:
1754:
1750:
1746:
1742:
1738:
1731:
1728:
1723:
1719:
1714:
1709:
1704:
1699:
1695:
1691:
1687:
1680:
1678:
1674:
1669:
1665:
1661:
1657:
1653:
1649:
1645:
1641:
1634:
1631:
1626:
1622:
1617:
1612:
1607:
1602:
1598:
1594:
1590:
1583:
1581:
1577:
1572:
1568:
1563:
1558:
1554:
1550:
1546:
1542:
1538:
1531:
1528:
1523:
1519:
1515:
1511:
1507:
1503:
1499:
1495:
1488:
1485:
1480:
1476:
1471:
1466:
1461:
1456:
1452:
1448:
1444:
1437:
1434:
1429:
1423:
1420:
1415:
1411:
1407:
1403:
1399:
1395:
1387:
1384:
1379:
1375:
1369:
1366:
1361:
1357:
1351:
1348:
1344:
1340:
1335:
1333:
1331:
1327:
1323:
1319:
1314:
1312:
1310:
1306:
1299:
1297:
1295:
1291:
1286:
1278:
1276:
1274:
1270:
1267:
1263:
1259:
1255:
1247:
1245:
1243:
1239:
1235:
1231:
1227:
1223:
1219:
1211:
1209:
1207:
1203:
1201:
1197:
1193:
1189:
1185:
1181:
1177:
1173:
1169:
1165:
1161:
1157:
1153:
1150:
1146:
1142:
1138:
1126:
1121:
1117:
1113:
1110:
1106:
1099:
1097:
1094:
1090:
1086:
1082:
1079:
1075:
1071:
1064:
1062:
1058:
1054:
1050:
1044:
1040:
1037:
1031:
1029:
1023:
1019:
1015:
1011:
1007:
1003:
999:
996:
992:
985:
983:
979:
975:
971:
965:
961:
958:
952:
950:
944:
940:
936:
932:
928:
924:
920:
917:
915:RefSeq (mRNA)
913:
906:
905:
900:
896:
893:
887:
886:
881:
877:
874:
872:
868:
861:
860:
855:
851:
848:
842:
841:
836:
832:
829:
827:
823:
816:
815:
810:
806:
803:
797:
796:
791:
787:
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745:
741:
736:
730:
727:
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712:
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704:cell division
702:
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684:
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629:
623:
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604:Gene ontology
601:
597:
585:
580:
576:
569:
562:
557:
554:
552:
548:
540:
535:
524:
520:
517:hair follicle
516:
512:
508:
504:
500:
497:parotid gland
496:
492:
488:
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480:
475:
472:
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458:
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119:
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107:
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97:
86:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1964:
1960:
1950:
1917:
1913:
1906:
1876:(2): 90–96.
1873:
1869:
1863:
1826:
1822:
1812:
1801:. Retrieved
1797:
1787:
1744:
1740:
1730:
1693:
1689:
1643:
1639:
1633:
1596:
1592:
1544:
1540:
1530:
1497:
1494:FEBS Letters
1493:
1487:
1450:
1446:
1436:
1422:
1397:
1393:
1386:
1377:
1368:
1359:
1350:
1293:
1289:
1284:
1282:
1265:
1258:X chromosome
1253:
1251:
1241:
1237:
1215:
1205:
1204:
1148:
1140:
1136:
1135:
1061:NP_001345154
1053:NP_001277642
1049:NP_001071180
1046:
1028:NP_001362304
1025:
1014:NP_001269347
1010:NP_001036216
1006:NP_001036215
1002:NP_001036214
982:NM_001358225
974:NM_001290713
970:NM_001077712
967:
949:NM_001375375
946:
935:NM_001282418
931:NM_001042751
927:NM_001042750
923:NM_001042749
902:
883:
857:
838:
812:
793:
773:
768:
505:carotid body
401:
394:
259:124,422,664
246:123,960,212
121:External IDs
72:
1182:and either
1168:DNA looping
653:nucleoplasm
435:sural nerve
360:41,366,062
347:41,238,194
339:X|X A4
99:Identifiers
1803:2018-02-13
1599:: e77848.
1345:, May 2017
1324:, May 2017
1300:References
1222:chromatids
719:cell cycle
648:chromosome
405:(ortholog)
142:HomoloGene
1967:: 88–95.
1942:252792610
1898:204703545
1779:252025964
1696:(1): 32.
1279:Mutations
1248:Structure
1057:NP_067440
1018:NP_006594
978:NM_021465
939:NM_006603
759:Orthologs
658:chromatin
150:GeneCards
2005:Category
1991:35495284
1934:36216271
1890:31609727
1855:26871722
1792:Cosmic.
1771:36275363
1722:32778134
1668:22909640
1660:24854081
1625:35959892
1571:11076961
1522:39397443
1514:23831059
1479:27742736
1341:–
1320:–
1230:interact
1212:Function
1109:Wikidata
738:Sources:
643:membrane
1982:9051973
1846:4752446
1762:9583756
1713:7418333
1616:9439679
1562:2169443
1470:5131750
1414:9305759
1343:Ensembl
1322:Ensembl
1188:meiosis
1156:Cohesin
1145:protein
1143:) is a
871:UniProt
826:Ensembl
765:Species
744:QuickGO
714:meiosis
668:nucleus
638:cytosol
380:pattern
138:1098583
106:Aliases
1989:
1979:
1940:
1932:
1896:
1888:
1853:
1843:
1777:
1769:
1759:
1720:
1710:
1666:
1658:
1623:
1613:
1569:
1559:
1520:
1512:
1477:
1467:
1412:
1095:search
1093:PubMed
904:O35638
885:Q8N3U4
781:Entrez
551:BioGPS
130:300826
1938:S2CID
1894:S2CID
1775:S2CID
1664:S2CID
1593:eLife
1518:S2CID
1290:STAG2
1285:STAG2
1266:STAG2
1254:STAG2
1238:STAG2
1234:STAG1
1232:with
1206:STAG2
1192:SMC1B
1180:RAD21
1149:STAG2
814:20843
795:10735
774:Mouse
769:Human
740:Amigo
403:Mouse
396:Human
343:Start
278:Mouse
242:Start
175:Human
154:STAG2
146:38206
113:STAG2
22:STAG2
1987:PMID
1930:PMID
1886:PMID
1851:PMID
1767:PMID
1718:PMID
1656:PMID
1621:PMID
1567:PMID
1510:PMID
1475:PMID
1410:PMID
1394:Gene
1294:STAG
1198:and
1196:REC8
1176:SMC1
1172:SMC3
1166:and
1152:gene
386:Bgee
334:Band
295:Chr.
238:Xq25
233:Band
192:Chr.
126:OMIM
83:4PK7
79:4PJW
75:4PJU
56:RCSB
53:PDBe
1977:PMC
1969:doi
1922:doi
1878:doi
1841:PMC
1831:doi
1757:PMC
1749:doi
1708:PMC
1698:doi
1648:doi
1611:PMC
1601:doi
1557:PMC
1549:doi
1545:151
1502:doi
1498:587
1465:PMC
1455:doi
1402:doi
1398:195
1200:SA3
1184:SA1
1141:SA2
356:End
255:End
158:OMA
134:MGI
46:PDB
2007::
1985:.
1975:.
1965:38
1963:.
1959:.
1936:.
1928:.
1918:65
1916:.
1892:.
1884:.
1874:29
1872:.
1849:.
1839:.
1827:12
1825:.
1821:.
1796:.
1773:.
1765:.
1755:.
1743:.
1739:.
1716:.
1706:.
1694:13
1692:.
1688:.
1676:^
1662:.
1654:.
1644:14
1642:.
1619:.
1609:.
1597:11
1595:.
1591:.
1579:^
1565:.
1555:.
1543:.
1539:.
1516:.
1508:.
1496:.
1473:.
1463:.
1449:.
1445:.
1408:.
1396:.
1376:.
1358:.
1329:^
1308:^
1202:.
1194:,
1178:,
1174:,
1162:,
742:/
362:bp
349:bp
261:bp
248:bp
156:;
152::
148:;
144::
140:;
136::
132:;
128::
81:,
77:,
1993:.
1971::
1944:.
1924::
1900:.
1880::
1857:.
1833::
1806:.
1781:.
1751::
1745:2
1724:.
1700::
1670:.
1650::
1627:.
1603::
1573:.
1551::
1524:.
1504::
1481:.
1457::
1451:6
1430:.
1416:.
1404::
1380:.
1362:.
1242:,
1139:(
280:)
177:)
160::
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