297:
274:
171:
196:
548:
303:
202:
1060:). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (
50:
1474:
Wines ME, Lee L, Katari MS, Zhang L, DeRossi C, Shi Y, Perkins S, Feldman M, McCombie WR, Holdener BC (February 2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis".
1506:"Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress"
1445:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1379:
Strauss JF, Kishida T, Christenson LK, Fujimoto T, Hiroi H (April 2003). "START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells".
310:
209:
736:
717:
132:
1416:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
1064:). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5.
1061:
1140:
1619:
1122:
1167:"The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6"
296:
940:
947:
273:
1227:
1109:
1088:
1624:
195:
170:
1105:
47:
1084:
1018:
112:
1021:(START) domain. It is also part of the StarD4 subfamily of START domain proteins, sharing 34% sequence identity with
309:
208:
1328:"Steroidogenic acute regulatory-related lipid transfer domain protein 5 localization and regulation in renal tubules"
1037:. STARD5 binds both cholesterol and 25-hydroxycholesterol and appears to function to redistribute cholesterol to the
1574:
Rodriguez-Agudo D, Ren S, Hylemon PB, Montañez R, Redford K, Natarajan R, Medina MA, Gil G, Pandak WM (June 2006).
1241:
Rodriguez-Agudo D, Ren S, Hylemon PB, Montañez R, Redford K, Natarajan R, Medina MA, Gil G, Pandak WM (June 2006).
1048:
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g.,
302:
201:
781:
120:
1539:
Rodriguez-Agudo D, Ren S, Hylemon PB, Redford K, Natarajan R, Del
Castillo A, Gil G, Pandak WM (August 2005).
1285:
Rodriguez-Agudo D, Ren S, Hylemon PB, Redford K, Natarajan R, Del
Castillo A, Gil G, Pandak WM (August 2005).
762:
1057:
1038:
184:
1178:
99:
1326:
Chen YC, Meier RK, Zheng S, Khundmiri SJ, Tseng MT, Lederer ED, Epstein PN, Clark BJ (August 2009).
1404:
144:
923:
902:
876:
855:
851:
547:
1597:
1562:
1527:
1492:
1462:
1433:
1396:
1357:
1308:
1264:
1206:
92:
40:
1587:
1552:
1517:
1484:
1454:
1425:
1388:
1347:
1339:
1298:
1254:
1196:
1186:
1053:
389:
320:
264:
219:
140:
1042:
364:
1182:
1352:
1327:
1458:
1392:
1201:
1166:
651:
646:
641:
625:
620:
604:
599:
594:
589:
1613:
1429:
1034:
576:
124:
1408:
382:
161:
1165:
Soccio RE, Adams RM, Romanowski MJ, Sehayek E, Burley SK, Breslow JL (May 2002).
148:
1343:
1145:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1127:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1014:
1592:
1575:
1557:
1540:
1303:
1286:
1259:
1242:
1171:
Proceedings of the
National Academy of Sciences of the United States of America
1033:
The protein is most prevalent in the kidney and the liver where it is found in
465:
281:
178:
128:
681:
525:
403:
348:
335:
247:
234:
136:
1601:
1566:
1531:
1522:
1505:
1496:
1488:
1400:
1361:
1312:
1268:
1210:
1191:
1466:
1437:
987:
982:
971:
826:
807:
1003:
793:
748:
69:
1049:
1045:. Increased levels of StarD5 increase free cholesterol in the cell.
1022:
955:
703:
666:
662:
1010:
556:
116:
1541:"Human StarD5, a cytosolic StAR-related lipid binding protein"
1287:"Human StarD5, a cytosolic StAR-related lipid binding protein"
1504:
Soccio RE, Adams RM, Maxwell KN, Breslow JL (May 2005).
372:
537:
1576:"Localization of StarD5 cholesterol binding protein"
1243:"Localization of StarD5 cholesterol binding protein"
916:
895:
869:
844:
1101:
1099:
1097:
1080:
1078:
1076:
319:
218:
103:, StAR related lipid transfer domain containing 5
1332:American Journal of Physiology. Renal Physiology
1228:"Entrez Gene: STARD5 START domain containing 5"
16:Protein-coding gene in the species Homo sapiens
1280:
1278:
1160:
1158:
1156:
1154:
1106:GRCm38: Ensembl release 89: ENSMUSG00000046027
1041:with which the protein associates and/or the
8:
1085:GRCh38: Ensembl release 89: ENSG00000172345
677:
572:
360:
259:
156:
58:
1591:
1556:
1521:
1351:
1302:
1258:
1200:
1190:
1222:
1220:
1072:
1017:long, consisting almost entirely of a
18:
1000:StAR-related lipid transfer protein 5
324:
285:
280:
223:
182:
177:
7:
1381:Molecular and Cellular Endocrinology
1510:The Journal of Biological Chemistry
913:
892:
866:
841:
817:
798:
772:
753:
727:
708:
542:
460:
398:
377:
14:
1006:that in humans is encoded by the
652:bile acid and bile salt transport
546:
308:
301:
295:
272:
207:
200:
194:
169:
557:More reference expression data
526:More reference expression data
1:
1459:10.1016/S0378-1119(97)00411-3
1393:10.1016/S0303-7207(03)00063-7
605:cholesterol transfer activity
492:epithelium of small intestine
293:
192:
1620:Genes on human chromosome 15
1430:10.1016/0378-1119(94)90802-8
1344:10.1152/ajprenal.90433.2008
1641:
1593:10.1194/jlr.M500447-JLR200
1558:10.1194/jlr.M400501-JLR200
1304:10.1194/jlr.M400501-JLR200
1260:10.1194/jlr.M500447-JLR200
430:mucosa of transverse colon
1580:Journal of Lipid Research
1545:Journal of Lipid Research
1291:Journal of Lipid Research
1247:Journal of Lipid Research
1141:"Mouse PubMed Reference:"
1123:"Human PubMed Reference:"
986:
981:
977:
970:
954:
935:
920:
899:
888:
873:
848:
837:
824:
820:
805:
801:
792:
779:
775:
760:
756:
747:
734:
730:
715:
711:
702:
687:
680:
676:
660:
575:
571:
554:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1013:. The protein is a 213
941:Chr 15: 81.31 – 81.32 Mb
1523:10.1074/jbc.M501778200
1489:10.1006/geno.2000.6466
1192:10.1073/pnas.052143799
948:Chr 7: 83.28 – 83.3 Mb
1625:Genes mutated in mice
1039:endoplasmic reticulum
1019:StAR-related transfer
185:Chromosome 15 (human)
508:skin of external ear
326:7 D3|7 47.43 cM
287:Chromosome 7 (mouse)
62:List of PDB id codes
35:Available structures
1183:2002PNAS...99.6943S
600:cholesterol binding
442:canal of the cervix
414:right lobe of liver
782:ENSMUSG00000046027
647:cholesterol import
635:Biological process
614:Cellular component
583:Molecular function
512:left lobe of liver
149:STARD5 - orthologs
1054:liver X receptors
997:
996:
993:
992:
966:
965:
931:
930:
910:
909:
884:
883:
863:
862:
833:
832:
814:
813:
788:
787:
769:
768:
743:
742:
724:
723:
672:
671:
590:bile acid binding
567:
566:
563:
562:
532:
531:
519:
518:
457:
456:
355:
354:
254:
253:
81:
80:
77:
76:
45:Ortholog search:
1632:
1605:
1595:
1570:
1560:
1535:
1525:
1500:
1470:
1441:
1412:
1366:
1365:
1355:
1323:
1317:
1316:
1306:
1282:
1273:
1272:
1262:
1238:
1232:
1231:
1224:
1215:
1214:
1204:
1194:
1162:
1149:
1148:
1137:
1131:
1130:
1119:
1113:
1103:
1092:
1082:
979:
978:
950:
943:
926:
914:
905:
893:
889:RefSeq (protein)
879:
867:
858:
842:
818:
799:
773:
754:
728:
709:
678:
573:
559:
550:
543:
528:
468:
466:Top expressed in
461:
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
1640:
1639:
1635:
1634:
1633:
1631:
1630:
1629:
1610:
1609:
1608:
1573:
1538:
1516:(19): 19410–8.
1503:
1473:
1453:(1–2): 149–56.
1444:
1415:
1378:
1374:
1372:Further reading
1369:
1325:
1324:
1320:
1284:
1283:
1276:
1240:
1239:
1235:
1226:
1225:
1218:
1164:
1163:
1152:
1139:
1138:
1134:
1121:
1120:
1116:
1104:
1095:
1083:
1074:
1070:
1043:plasma membrane
1031:
988:View/Edit Mouse
983:View/Edit Human
946:
939:
936:Location (UCSC)
922:
901:
875:
854:
850:
763:ENSG00000172345
656:
642:lipid transport
630:
609:
555:
524:
515:
510:
506:
502:
498:
494:
490:
488:proximal tubule
486:
482:
478:
464:
453:
448:
444:
440:
436:
432:
428:
424:
420:
418:skin of abdomen
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
1638:
1636:
1628:
1627:
1622:
1612:
1611:
1607:
1606:
1586:(6): 1168–75.
1571:
1551:(8): 1615–23.
1536:
1501:
1471:
1442:
1424:(1–2): 171–4.
1413:
1387:(1–2): 59–65.
1375:
1373:
1370:
1368:
1367:
1318:
1297:(8): 1615–23.
1274:
1253:(6): 1168–75.
1233:
1216:
1177:(10): 6943–8.
1150:
1132:
1114:
1093:
1071:
1069:
1066:
1030:
1027:
995:
994:
991:
990:
985:
975:
974:
968:
967:
964:
963:
961:
959:
952:
951:
944:
937:
933:
932:
929:
928:
918:
917:
911:
908:
907:
897:
896:
890:
886:
885:
882:
881:
871:
870:
864:
861:
860:
846:
845:
839:
835:
834:
831:
830:
822:
821:
815:
812:
811:
803:
802:
796:
790:
789:
786:
785:
777:
776:
770:
767:
766:
758:
757:
751:
745:
744:
741:
740:
732:
731:
725:
722:
721:
713:
712:
706:
700:
699:
694:
689:
685:
684:
674:
673:
670:
669:
658:
657:
655:
654:
649:
644:
638:
636:
632:
631:
629:
628:
623:
617:
615:
611:
610:
608:
607:
602:
597:
592:
586:
584:
580:
579:
569:
568:
565:
564:
561:
560:
552:
551:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
480:lacrimal gland
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
446:body of uterus
443:
439:
435:
431:
427:
423:
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1637:
1626:
1623:
1621:
1618:
1617:
1615:
1603:
1599:
1594:
1589:
1585:
1581:
1577:
1572:
1568:
1564:
1559:
1554:
1550:
1546:
1542:
1537:
1533:
1529:
1524:
1519:
1515:
1511:
1507:
1502:
1498:
1494:
1490:
1486:
1482:
1478:
1472:
1468:
1464:
1460:
1456:
1452:
1448:
1443:
1439:
1435:
1431:
1427:
1423:
1419:
1414:
1410:
1406:
1402:
1398:
1394:
1390:
1386:
1382:
1377:
1376:
1371:
1363:
1359:
1354:
1349:
1345:
1341:
1338:(2): F380-8.
1337:
1333:
1329:
1322:
1319:
1314:
1310:
1305:
1300:
1296:
1292:
1288:
1281:
1279:
1275:
1270:
1266:
1261:
1256:
1252:
1248:
1244:
1237:
1234:
1229:
1223:
1221:
1217:
1212:
1208:
1203:
1198:
1193:
1188:
1184:
1180:
1176:
1172:
1168:
1161:
1159:
1157:
1155:
1151:
1146:
1142:
1136:
1133:
1128:
1124:
1118:
1115:
1111:
1107:
1102:
1100:
1098:
1094:
1090:
1086:
1081:
1079:
1077:
1073:
1067:
1065:
1063:
1059:
1055:
1051:
1046:
1044:
1040:
1036:
1035:Kupffer cells
1028:
1026:
1024:
1020:
1016:
1012:
1009:
1005:
1001:
989:
984:
980:
976:
973:
969:
962:
960:
957:
953:
949:
945:
942:
938:
934:
927:
925:
919:
915:
912:
906:
904:
898:
894:
891:
887:
880:
878:
872:
868:
865:
859:
857:
853:
847:
843:
840:
838:RefSeq (mRNA)
836:
829:
828:
823:
819:
816:
810:
809:
804:
800:
797:
795:
791:
784:
783:
778:
774:
771:
765:
764:
759:
755:
752:
750:
746:
739:
738:
733:
729:
726:
720:
719:
714:
710:
707:
705:
701:
698:
695:
693:
690:
686:
683:
679:
675:
668:
664:
659:
653:
650:
648:
645:
643:
640:
639:
637:
634:
633:
627:
626:mitochondrion
624:
622:
619:
618:
616:
613:
612:
606:
603:
601:
598:
596:
595:lipid binding
593:
591:
588:
587:
585:
582:
581:
578:
577:Gene ontology
574:
570:
558:
553:
549:
544:
541:
539:
535:
527:
522:
511:
507:
503:
499:
495:
491:
487:
483:
479:
475:
474:
471:
467:
462:
459:
450:skin of thigh
449:
445:
441:
437:
433:
429:
425:
421:
417:
413:
412:
409:
405:
400:
397:
396:
393:
391:
387:
385:
384:
380:
379:
376:
374:
370:
366:
362:
358:
350:
345:
341:
337:
332:
322:
318:
311:
304:
298:
291:
283:
279:
275:
270:
266:
261:
257:
249:
244:
240:
236:
231:
221:
217:
210:
203:
197:
190:
186:
180:
176:
172:
167:
163:
158:
154:
150:
146:
142:
138:
134:
130:
126:
122:
118:
114:
106:
101:
94:
89:
84:
73:
71:
65:
60:
57:
56:
52:
49:
42:
38:
33:
29:
25:
20:
1583:
1579:
1548:
1544:
1513:
1509:
1483:(1): 88–98.
1480:
1476:
1450:
1446:
1421:
1417:
1384:
1380:
1335:
1331:
1321:
1294:
1290:
1250:
1246:
1236:
1174:
1170:
1144:
1135:
1126:
1117:
1047:
1032:
1007:
999:
998:
921:
900:
874:
849:
825:
806:
780:
761:
735:
716:
696:
691:
496:human kidney
484:right kidney
388:
381:
108:External IDs
67:
1015:amino acids
504:granulocyte
422:skin of leg
347:83,302,335
334:83,281,167
246:81,324,183
233:81,309,053
86:Identifiers
1614:Categories
1112:, May 2017
1091:, May 2017
1068:References
426:ectocervix
392:(ortholog)
129:HomoloGene
1052:) and by
924:NP_075866
903:NP_871629
877:NM_023377
856:NM_181900
852:NM_030574
682:Orthologs
137:GeneCards
1602:16534142
1567:15897605
1532:15760897
1497:11247670
1477:Genomics
1401:12770731
1362:19474188
1313:15897605
1269:16534142
1211:12011452
1108:–
1087:–
1029:Function
972:Wikidata
661:Sources:
1467:9373149
1438:8125298
1409:7301974
1353:2724253
1179:Bibcode
1110:Ensembl
1089:Ensembl
1056:(e.g.,
1004:protein
794:UniProt
749:Ensembl
688:Species
667:QuickGO
621:cytosol
367:pattern
225:15q25.1
125:2156765
93:Aliases
1600:
1565:
1530:
1495:
1465:
1436:
1407:
1399:
1360:
1350:
1311:
1267:
1209:
1202:124508
1199:
1050:SREBP1
1023:STARD4
1008:STARD5
958:search
956:PubMed
827:Q9EPQ7
808:Q9NSY2
737:170460
704:Entrez
538:BioGPS
438:vagina
434:rectum
141:STARD5
117:607050
100:STARD5
22:STARD5
1405:S2CID
1002:is a
718:80765
697:Mouse
692:Human
663:Amigo
500:liver
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
133:11346
1598:PMID
1563:PMID
1528:PMID
1493:PMID
1463:PMID
1447:Gene
1434:PMID
1418:Gene
1397:PMID
1358:PMID
1309:PMID
1265:PMID
1207:PMID
1062:STAR
1058:LXRA
1011:gene
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
113:OMIM
70:2R55
51:RCSB
48:PDBe
1588:doi
1553:doi
1518:doi
1514:280
1485:doi
1455:doi
1451:200
1426:doi
1422:138
1389:doi
1385:202
1348:PMC
1340:doi
1336:297
1299:doi
1255:doi
1197:PMC
1187:doi
476:lip
343:End
242:End
145:OMA
121:MGI
41:PDB
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349:bp
336:bp
248:bp
235:bp
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