326:
29:
303:
200:
225:
584:
577:
332:
231:
1290:
1262:
mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was first identified as a kinase that resembles budding yeast Ste20 (Creasy and
Chernoff, 1996) and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996; Lee et al., 2001).
1315:
with itself or heterodimerizing with its homolog, MST1 (STK4). Heterodimerization has been shown to exhibit a roughly six-fold weaker binding affinity than homodimerization with MST2, as well as lower kinase activity compared to both MST2/MST2 and MST1/MST1 homodimers. In addition to activation by
1361:
In the mammalian Hippo signaling pathway, MST2, along with its homolog MST1, serves as an upstream kinase whose catalytic activity is responsible for downstream events leading to downregulation of proliferation-associated genes and increased transcription of proapoptotic genes. When MST2 binds to
1261:
activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the
55:
1278:, an inhibitory domain, and a catalytic kinase domain at the N-terminus. The SARAH (Salvador/RASSF/Hpo) domain has been found to mediate dimeric interactions between MST2 and RASSF enzymes, a class of tumor suppressors that serve an important role in activating
1286:, a non-catalytic polypeptide responsible for bringing MST2 to an apoptotic pathway. When the MST2 kinase domain is in its active state, a threonine residue residing on an alpha helix at the 180th position (T180) is autophosphorylated.
1328:
3 is activated during apoptosis, MST2 is cleaved, resulting in removal of the regulatory SARAH and inhibitory domains and thus regulation of MST2's kinase activity. Because cleavage by caspase 3 also cleaves off MST2's
2523:
Callus BA, Verhagen AM, Vaux DL (September 2006). "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation".
1591:
Liu G, Shi Z, Jiao S, Zhang Z, Wang W, Chen C, Hao Q, Hao Q, Zhang M, Feng M, Xu L, Zhang Z, Zhou Z, Zhang M (March 2014). "Structure of MST2 SARAH domain provides insights into its interaction with RAPL".
1386:, preventing its movement into the nucleus and activation of transcription of pro-proliferative, anti-apoptotic and migration-associated genes. In the cytoplasm, YAP1 is marked for degradation by the
2305:
De Souza PM, Kankaanranta H, Michael A, Barnes PJ, Giembycz MA, Lindsay MA (May 2002). "Caspase-catalyzed cleavage and activation of Mst1 correlates with eosinophil but not neutrophil apoptosis".
2132:
Schultz SJ, Nigg EA (October 1993). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of
Aspergillus nidulans".
2604:
Seidel C, Schagdarsurengin U, Blümke K, Würl P, Pfeifer GP, Hauptmann S, Taubert H, Dammann R (October 2007). "Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma".
1402:
binds to the SARAH domain of MST2 and prevents RASSF1A-mediated MST2 dimerization and subsequent downstream pro-apoptotic signaling. Research has shown that in cells with loss of
1390:. Additionally, MST2 phosphorylates transcription factors in the FOXO (Forkhead box O) family, which diffuse into the nucleus and activate transcription of pro-apoptotic genes.
2457:
Chan EH, Nousiainen M, Chalamalasetty RB, Schäfer A, Nigg EA, Silljé HH (March 2005). "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1".
2734:
339:
238:
1406:, a tumor suppressor that is frequently mutated in cancers, Akt activity is upregulated, resulting in increased MST2 inactivation and undesirable cell proliferation.
2494:
Oh HJ, Lee KK, Song SJ, Jin MS, Song MS, Lee JH, Im CR, Lee JO, Yonehara S, Lim DS (March 2006). "Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis".
2412:
O'Neill E, Rushworth L, Baccarini M, Kolch W (December 2004). "Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1".
952:
161:
933:
2727:
1483:
1465:
2894:
2377:
Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (July 2004).
325:
52:
2773:
1270:
Human serine/threonine-protein kinase 3 (STK3, or MST2) is a 56,301 Da monomer with three domains: a SARAH domain, composed of a long
1183:
1176:
302:
1345:
Inactivation of MST2 can be accomplished in several ways, including inhibition of MST2 homodimerization and autophosphorylation by
2720:
1563:
1798:
Lessard-Beaudoin M, Laroche M, Loudghi A, Demers MJ, Denault JB, Grenier G, Riechers SP, Wanker EE, Graham RK (November 2016).
1452:
1431:
2153:
Creasy CL, Chernoff J (December 1995). "Cloning and characterization of a member of the MST subfamily of Ste20-like kinases".
2641:
Matallanas D, Romano D, Yee K, Meissl K, Kucerova L, Piazzolla D, Baccarini M, Vass JK, Kolch W, O'neill E (September 2007).
2643:"RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein"
1448:
1627:
Sánchez-Sanz G, Tywoniuk B, Matallanas D, Romano D, Nguyen LK, Kholodenko BN, Rosta E, Kolch W, Buchete NV (October 2016).
224:
199:
1427:
2272:"MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation"
141:
338:
237:
2184:"Signal termination in bacterial chemotaxis: CheZ mediates dephosphorylation of free rather than switch-bound CheY"
2344:"Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis"
331:
230:
28:
2379:"The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death"
997:
149:
1353:), blocking autophosphorylation of Thr180, MST2 cleavage, kinase activity, and translocation to the nucleus.
2755:
2747:
978:
1330:
2844:
2421:
2195:
1861:
1640:
1514:
213:
128:
2743:
1349:, which binds to the MST2 SARAH domain, and phosphorylation of the highly conserved Thr117 by Akt (
1308:
1159:
1130:
1126:
1100:
1071:
1067:
2629:
2592:
2549:
2482:
2445:
2330:
1927:
1919:
1830:
173:
1155:
1134:
1096:
1075:
1800:"Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process"
2692:
2672:
2621:
2584:
2541:
2511:
2474:
2437:
2400:
2365:
2322:
2293:
2258:
2223:
2170:
2141:
2120:
2074:
2025:
1976:
1908:
1889:
1822:
1773:
1724:
1668:
1609:
1542:
121:
45:
2712:
2781:
2662:
2654:
2613:
2574:
2533:
2503:
2466:
2429:
2390:
2355:
2314:
2283:
2248:
2213:
2203:
2162:
2110:
2064:
2056:
2015:
2007:
1966:
1958:
1900:
1879:
1869:
1814:
1763:
1755:
1714:
1706:
1658:
1648:
1601:
1532:
1522:
1379:
1350:
583:
418:
349:
293:
248:
1316:
straurosporine and FAS ligand, STK3 has been found to be activated through dissociation of
2045:"Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt"
1577:
576:
393:
169:
1818:
2425:
2199:
1865:
1644:
1518:
2667:
2642:
2069:
2044:
2020:
1995:
1971:
1946:
1884:
1849:
1768:
1744:"Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5"
1743:
1719:
1694:
1663:
1628:
733:
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
867:
862:
857:
852:
847:
842:
837:
832:
827:
822:
817:
812:
807:
802:
797:
792:
787:
782:
777:
772:
767:
762:
757:
752:
747:
742:
737:
732:
727:
711:
706:
701:
696:
680:
675:
670:
665:
660:
655:
650:
645:
640:
635:
630:
625:
2888:
2701:
2537:
2218:
2183:
2166:
1850:"Regulation of Proapoptotic Mammalian ste20–Like Kinase MST2 by the IGF1-Akt Pathway"
1537:
1502:
1312:
612:
2633:
2561:
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006).
2486:
2449:
153:
2596:
2563:"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"
2553:
2334:
1834:
1333:, the MST2 kinase fragment can diffuse into the nucleus and phosphorylate Ser14 of
411:
190:
2507:
2060:
2658:
2011:
1904:
1874:
1653:
177:
1799:
1710:
1488:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1470:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1403:
1387:
1334:
1321:
1289:
1275:
2579:
2562:
2188:
Proceedings of the
National Academy of Sciences of the United States of America
2099:"Cloning and characterization of a human protein kinase with homology to Ste20"
1507:
Proceedings of the
National Academy of Sciences of the United States of America
494:
1996:"Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device"
1759:
1605:
1271:
310:
207:
157:
2318:
2208:
2115:
2098:
1527:
1324:(Trx1) from STK3 under oxidative stress. Recent studies have shown that when
728:
regulation of cell differentiation involved in embryonic placenta development
2433:
2043:
Romano D, Matallanas D, Weitsman G, Preisinger C, Ng T, Kolch W (Feb 2010).
1279:
897:
554:
432:
377:
364:
276:
263:
165:
2676:
2625:
2588:
2545:
2515:
2478:
2470:
2441:
2404:
2395:
2378:
2369:
2360:
2343:
2326:
2297:
2288:
2271:
2262:
2253:
2236:
2078:
2029:
1980:
1962:
1912:
1893:
1826:
1777:
1728:
1672:
1613:
2227:
2174:
2145:
2124:
1916:. If this is an intentional citation to a retracted paper, please replace
1578:"PhosphoSitePlus: Serine/threonine-protein kinase 3 - Protein Information"
1546:
1223:
1218:
2857:
1207:
1042:
1023:
2801:
2796:
2706:
2696:
1994:
Nguyen LK, Matallanas DG, Romano D, Kholodenko BN, Kolch W (Jan 2015).
1325:
1009:
964:
98:
94:
90:
86:
82:
78:
74:
2873:
2811:
2617:
1503:"Newly identified stress-responsive protein kinases, Krs-1 and Krs-2"
1274:
at the C-terminus that when dimerized, forms an antiparallel dimeric
1258:
1239:
1191:
919:
1564:"Entrez Gene: STK3 serine/threonine kinase 3 (STE20 homolog, yeast)"
2829:
2824:
2786:
1399:
1375:
1371:
1367:
1363:
1346:
1288:
1848:
Kim D, Shu S, Coppola MD, Kaneko S, Yuan Z, Cheng JQ (Mar 2010).
882:
878:
2852:
2819:
2791:
2763:
1793:
1791:
1789:
1787:
1383:
1317:
1283:
1246:
758:
positive regulation of DNA-binding transcription factor activity
145:
2716:
2270:
Lee KK, Ohyama T, Yajima N, Tsubuki S, Yonehara S (June 2001).
848:
positive regulation of protein serine/threonine kinase activity
803:
cell differentiation involved in embryonic placenta development
592:
1293:
Dimerized MST2 SARAH domains with labeled hydrophobic residues
1695:"MST1/MST2 Protein Kinases: Regulation and Physiologic Roles"
2691:
Overview of all the structural information available in the
2237:"Detection of a novel quiescence-dependent protein kinase"
401:
2182:
Bren A, Welch M, Blat Y, Eisenbach M (September 1996).
1629:"SARAH Domain-Mediated MST2-RASSF Dimeric Interactions"
823:
negative regulation of canonical Wnt signaling pathway
566:
833:
negative regulation of cell population proliferation
2866:
2843:
2810:
2772:
2754:
1382:. In turn, LATS1/LATS2 phosphorylates and inhibits
1362:SAV1 through its SARAH domain, MST2 phosphorylates
1148:
1119:
1089:
1060:
1444:
1442:
1440:
1423:
1421:
1419:
641:protein serine/threonine kinase activator activity
1501:Taylor LK, Wang HC, Erikson RL (September 1996).
858:stress-activated protein kinase signaling cascade
738:positive regulation of protein kinase B signaling
348:
247:
1688:
1686:
1684:
1682:
808:positive regulation of fat cell differentiation
16:Protein-coding gene in the species Homo sapiens
1449:GRCm38: Ensembl release 89: ENSMUSG00000022329
2728:
1398:In many types of cancers, the proto-oncogene
8:
2705:(Serine/threonine-protein kinase 3) at the
1428:GRCh38: Ensembl release 89: ENSG00000104375
2735:
2721:
2713:
1930:|...|intentional=yes}}
893:
608:
389:
288:
185:
63:
2666:
2578:
2394:
2359:
2287:
2252:
2217:
2207:
2114:
2068:
2019:
1970:
1883:
1873:
1767:
1718:
1662:
1652:
1536:
1526:
2097:Creasy CL, Chernoff J (September 1995).
1947:"Mechanisms of Hippo pathway regulation"
1558:
1556:
793:positive regulation of apoptotic process
656:protein serine/threonine kinase activity
1945:Meng Z, Moroishi T, Guan K (Jan 2016).
1415:
132:, KRS1, MST2, serine/threonine kinase 3
2342:Deng Y, Pang A, Wang JH (April 2003).
798:positive regulation of protein binding
18:
868:activation of protein kinase activity
353:
314:
309:
252:
211:
206:
7:
1819:10.1016/j.neurobiolaging.2016.07.003
2383:The Journal of Biological Chemistry
2348:The Journal of Biological Chemistry
2276:The Journal of Biological Chemistry
2241:The Journal of Biological Chemistry
2235:Wang HC, Fecteau KA (August 2000).
2103:The Journal of Biological Chemistry
813:negative regulation of organ growth
1145:
1116:
1086:
1057:
1033:
1014:
988:
969:
943:
924:
788:central nervous system development
763:positive regulation of JNK cascade
571:
489:
427:
406:
14:
2134:Cell Growth & Differentiation
1242:that in humans is encoded by the
1236:Serine/threonine-protein kinase 3
743:intracellular signal transduction
2538:10.1111/j.1742-4658.2006.05427.x
853:regulation of mitotic cell cycle
582:
575:
337:
330:
324:
301:
236:
229:
223:
198:
27:
1693:Galan JA, Avruch J (Sep 2016).
863:regulation of apoptotic process
1742:Ni L, et al. (Oct 2013).
1282:, as well as between MST2 and
593:More reference expression data
555:More reference expression data
1:
2508:10.1158/0008-5472.CAN-05-2951
2061:10.1158/0008-5472.CAN-09-3147
1594:Journal of Structural Biology
636:protein dimerization activity
322:
221:
2659:10.1016/j.molcel.2007.08.008
2167:10.1016/0378-1119(95)00653-2
2012:10.4161/15384101.2014.973743
1905:10.1371/journal.pone.0289329
1875:10.1371/journal.pone.0009616
1654:10.1371/journal.pcbi.1005051
838:hepatocyte apoptotic process
2895:Genes on human chromosome 8
1711:10.1021/acs.biochem.6b00763
2911:
2580:10.1016/j.cell.2006.09.026
1633:PLOS Computational Biology
1307:STK3 is activated through
712:protein-containing complex
1760:10.1016/j.str.2013.07.008
1606:10.1016/j.jsb.2014.01.008
1484:"Mouse PubMed Reference:"
1466:"Human PubMed Reference:"
1222:
1217:
1213:
1206:
1190:
1171:
1152:
1123:
1112:
1093:
1064:
1053:
1040:
1036:
1021:
1017:
1008:
995:
991:
976:
972:
963:
950:
946:
931:
927:
918:
903:
896:
892:
876:
681:identical protein binding
611:
607:
590:
574:
565:
552:
501:
492:
439:
430:
400:
392:
388:
371:
358:
321:
300:
291:
287:
270:
257:
220:
197:
188:
184:
139:
136:
126:
119:
114:
71:
66:
49:
44:
39:
35:
26:
21:
2606:Molecular Carcinogenesis
2319:10.1182/blood.V99.9.3432
2209:10.1073/pnas.93.19.10090
2116:10.1074/jbc.270.37.21695
1528:10.1073/pnas.93.19.10099
1184:Chr 15: 34.88 – 35.18 Mb
2748:Hippo signaling pathway
2434:10.1126/science.1103233
1370:with the help of SAV1,
1337:, promoting apoptosis.
1177:Chr 8: 98.37 – 98.94 Mb
778:protein phosphorylation
773:endocardium development
676:protein kinase activity
2471:10.1038/sj.onc.1208445
2396:10.1074/jbc.M401699200
2361:10.1074/jbc.M211085200
2289:10.1074/jbc.M005109200
2254:10.1074/jbc.M000818200
1963:10.1101/gad.274027.115
1294:
541:atrioventricular valve
1922:|...}}
1899:(Retracted, see
1807:Neurobiology of Aging
1331:nuclear export signal
1292:
818:neural tube formation
783:primitive hemopoiesis
753:protein stabilization
671:magnesium ion binding
316:Chromosome 15 (mouse)
2845:Transcription factor
626:transferase activity
214:Chromosome 8 (human)
67:List of PDB id codes
40:Available structures
2426:2004Sci...306.2267O
2200:1996PNAS...9310090B
1866:2010PLoSO...5.9616K
1645:2016PLSCB..12E5051S
1519:1996PNAS...9310099T
1309:autophosphorylation
828:signal transduction
455:germinal epithelium
1295:
998:ENSMUSG00000022329
721:Biological process
690:Cellular component
631:nucleotide binding
619:Molecular function
447:tail of epididymis
2882:
2881:
2744:Signaling pathway
2420:(5705): 2267–70.
2109:(37): 21695–700.
1754:(10): 1757–1768.
1705:(39): 5507–5519.
1513:(19): 10099–104.
1394:Disease Relevance
1233:
1232:
1229:
1228:
1202:
1201:
1167:
1166:
1142:
1141:
1108:
1107:
1083:
1082:
1049:
1048:
1030:
1029:
1004:
1003:
985:
984:
959:
958:
940:
939:
888:
887:
843:apoptotic process
646:metal ion binding
603:
602:
599:
598:
561:
560:
548:
547:
486:
485:
471:corpus epididymis
384:
383:
283:
282:
110:
109:
106:
105:
50:Ortholog search:
2902:
2737:
2730:
2723:
2714:
2680:
2670:
2637:
2618:10.1002/mc.20317
2600:
2582:
2557:
2526:The FEBS Journal
2519:
2490:
2453:
2408:
2398:
2389:(28): 29247–54.
2373:
2363:
2338:
2301:
2291:
2282:(22): 19276–85.
2266:
2256:
2231:
2221:
2211:
2178:
2149:
2128:
2118:
2083:
2082:
2072:
2055:(3): 1195–1203.
2040:
2034:
2033:
2023:
1991:
1985:
1984:
1974:
1942:
1936:
1935:
1933:
1931:
1923:
1897:
1887:
1877:
1845:
1839:
1838:
1804:
1795:
1782:
1781:
1771:
1739:
1733:
1732:
1722:
1690:
1677:
1676:
1666:
1656:
1639:(10): e1005051.
1624:
1618:
1617:
1588:
1582:
1581:
1574:
1568:
1567:
1560:
1551:
1550:
1540:
1530:
1498:
1492:
1491:
1480:
1474:
1473:
1462:
1456:
1446:
1435:
1425:
1380:Merlin (protein)
1351:protein kinase B
1215:
1214:
1186:
1179:
1162:
1146:
1137:
1117:
1113:RefSeq (protein)
1103:
1087:
1078:
1058:
1034:
1015:
989:
970:
944:
925:
894:
609:
595:
586:
579:
572:
557:
497:
495:Top expressed in
490:
479:cartilage tissue
475:seminal vesicula
451:caput epididymis
435:
433:Top expressed in
428:
407:
390:
380:
367:
356:
341:
334:
328:
317:
305:
289:
279:
266:
255:
240:
233:
227:
216:
202:
186:
180:
178:STK3 - orthologs
131:
124:
101:
64:
58:
37:
36:
31:
19:
2910:
2909:
2905:
2904:
2903:
2901:
2900:
2899:
2885:
2884:
2883:
2878:
2862:
2839:
2806:
2774:Adaptor protein
2768:
2750:
2741:
2688:
2683:
2640:
2603:
2560:
2532:(18): 4264–76.
2522:
2496:Cancer Research
2493:
2465:(12): 2076–86.
2456:
2411:
2376:
2354:(14): 11760–7.
2341:
2304:
2269:
2247:(33): 25850–7.
2234:
2194:(19): 10090–3.
2181:
2152:
2131:
2096:
2092:
2090:Further reading
2087:
2086:
2042:
2041:
2037:
1993:
1992:
1988:
1944:
1943:
1939:
1925:
1917:
1915:
1898:
1847:
1846:
1842:
1802:
1797:
1796:
1785:
1741:
1740:
1736:
1692:
1691:
1680:
1626:
1625:
1621:
1590:
1589:
1585:
1576:
1575:
1571:
1562:
1561:
1554:
1500:
1499:
1495:
1482:
1481:
1477:
1464:
1463:
1459:
1447:
1438:
1426:
1417:
1412:
1396:
1359:
1357:MST2 substrates
1343:
1305:
1300:
1268:
1255:
1224:View/Edit Mouse
1219:View/Edit Human
1182:
1175:
1172:Location (UCSC)
1158:
1154:
1133:
1129:
1125:
1099:
1095:
1074:
1070:
1066:
979:ENSG00000104375
872:
768:hippo signaling
748:phosphorylation
716:
685:
661:protein binding
651:kinase activity
591:
581:
580:
553:
544:
539:
535:
531:
527:
523:
519:
515:
511:
507:
493:
482:
477:
473:
469:
465:
461:
457:
453:
449:
445:
443:Achilles tendon
431:
375:
362:
355:15|15 B3.1
354:
344:
343:
342:
335:
315:
292:Gene location (
274:
261:
253:
243:
242:
241:
234:
212:
189:Gene location (
140:
127:
120:
73:
51:
17:
12:
11:
5:
2908:
2906:
2898:
2897:
2887:
2886:
2880:
2879:
2877:
2876:
2870:
2868:
2864:
2863:
2861:
2860:
2855:
2849:
2847:
2841:
2840:
2838:
2837:
2832:
2827:
2822:
2816:
2814:
2808:
2807:
2805:
2804:
2799:
2794:
2789:
2784:
2778:
2776:
2770:
2769:
2767:
2766:
2760:
2758:
2752:
2751:
2742:
2740:
2739:
2732:
2725:
2717:
2711:
2710:
2687:
2686:External links
2684:
2682:
2681:
2647:Molecular Cell
2638:
2612:(10): 865–71.
2601:
2558:
2520:
2491:
2454:
2409:
2374:
2339:
2302:
2267:
2232:
2179:
2161:(1–2): 303–6.
2150:
2140:(10): 821–30.
2129:
2093:
2091:
2088:
2085:
2084:
2035:
2006:(2): 189–199.
1986:
1937:
1840:
1783:
1734:
1678:
1619:
1583:
1569:
1552:
1493:
1475:
1457:
1436:
1414:
1413:
1411:
1408:
1395:
1392:
1358:
1355:
1342:
1339:
1304:
1301:
1299:
1296:
1267:
1264:
1254:
1251:
1231:
1230:
1227:
1226:
1221:
1211:
1210:
1204:
1203:
1200:
1199:
1197:
1195:
1188:
1187:
1180:
1173:
1169:
1168:
1165:
1164:
1150:
1149:
1143:
1140:
1139:
1121:
1120:
1114:
1110:
1109:
1106:
1105:
1091:
1090:
1084:
1081:
1080:
1062:
1061:
1055:
1051:
1050:
1047:
1046:
1038:
1037:
1031:
1028:
1027:
1019:
1018:
1012:
1006:
1005:
1002:
1001:
993:
992:
986:
983:
982:
974:
973:
967:
961:
960:
957:
956:
948:
947:
941:
938:
937:
929:
928:
922:
916:
915:
910:
905:
901:
900:
890:
889:
886:
885:
874:
873:
871:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
815:
810:
805:
800:
795:
790:
785:
780:
775:
770:
765:
760:
755:
750:
745:
740:
735:
730:
724:
722:
718:
717:
715:
714:
709:
704:
699:
693:
691:
687:
686:
684:
683:
678:
673:
668:
663:
658:
653:
648:
643:
638:
633:
628:
622:
620:
616:
615:
605:
604:
601:
600:
597:
596:
588:
587:
569:
563:
562:
559:
558:
550:
549:
546:
545:
543:
542:
538:
537:abdominal wall
534:
530:
529:left lung lobe
526:
522:
518:
514:
510:
506:
505:tail of embryo
502:
499:
498:
487:
484:
483:
481:
480:
476:
472:
468:
464:
460:
456:
452:
448:
444:
440:
437:
436:
424:
423:
415:
404:
398:
397:
394:RNA expression
386:
385:
382:
381:
373:
369:
368:
360:
357:
352:
346:
345:
336:
329:
323:
319:
318:
313:
307:
306:
298:
297:
285:
284:
281:
280:
272:
268:
267:
259:
256:
251:
245:
244:
235:
228:
222:
218:
217:
210:
204:
203:
195:
194:
182:
181:
138:
134:
133:
125:
117:
116:
112:
111:
108:
107:
104:
103:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
2907:
2896:
2893:
2892:
2890:
2875:
2872:
2871:
2869:
2867:Other/unknown
2865:
2859:
2856:
2854:
2851:
2850:
2848:
2846:
2842:
2836:
2833:
2831:
2828:
2826:
2823:
2821:
2818:
2817:
2815:
2813:
2809:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2783:
2780:
2779:
2777:
2775:
2771:
2765:
2762:
2761:
2759:
2757:
2753:
2749:
2745:
2738:
2733:
2731:
2726:
2724:
2719:
2718:
2715:
2708:
2704:
2703:
2698:
2694:
2690:
2689:
2685:
2678:
2674:
2669:
2664:
2660:
2656:
2653:(6): 962–75.
2652:
2648:
2644:
2639:
2635:
2631:
2627:
2623:
2619:
2615:
2611:
2607:
2602:
2598:
2594:
2590:
2586:
2581:
2576:
2573:(3): 635–48.
2572:
2568:
2564:
2559:
2555:
2551:
2547:
2543:
2539:
2535:
2531:
2527:
2521:
2517:
2513:
2509:
2505:
2502:(5): 2562–9.
2501:
2497:
2492:
2488:
2484:
2480:
2476:
2472:
2468:
2464:
2460:
2455:
2451:
2447:
2443:
2439:
2435:
2431:
2427:
2423:
2419:
2415:
2410:
2406:
2402:
2397:
2392:
2388:
2384:
2380:
2375:
2371:
2367:
2362:
2357:
2353:
2349:
2345:
2340:
2336:
2332:
2328:
2324:
2320:
2316:
2313:(9): 3432–8.
2312:
2308:
2303:
2299:
2295:
2290:
2285:
2281:
2277:
2273:
2268:
2264:
2260:
2255:
2250:
2246:
2242:
2238:
2233:
2229:
2225:
2220:
2215:
2210:
2205:
2201:
2197:
2193:
2189:
2185:
2180:
2176:
2172:
2168:
2164:
2160:
2156:
2151:
2147:
2143:
2139:
2135:
2130:
2126:
2122:
2117:
2112:
2108:
2104:
2100:
2095:
2094:
2089:
2080:
2076:
2071:
2066:
2062:
2058:
2054:
2050:
2046:
2039:
2036:
2031:
2027:
2022:
2017:
2013:
2009:
2005:
2001:
1997:
1990:
1987:
1982:
1978:
1973:
1968:
1964:
1960:
1956:
1952:
1948:
1941:
1938:
1929:
1921:
1914:
1910:
1906:
1902:
1895:
1891:
1886:
1881:
1876:
1871:
1867:
1863:
1859:
1855:
1851:
1844:
1841:
1836:
1832:
1828:
1824:
1820:
1816:
1812:
1808:
1801:
1794:
1792:
1790:
1788:
1784:
1779:
1775:
1770:
1765:
1761:
1757:
1753:
1749:
1745:
1738:
1735:
1730:
1726:
1721:
1716:
1712:
1708:
1704:
1700:
1696:
1689:
1687:
1685:
1683:
1679:
1674:
1670:
1665:
1660:
1655:
1650:
1646:
1642:
1638:
1634:
1630:
1623:
1620:
1615:
1611:
1607:
1603:
1600:(3): 366–74.
1599:
1595:
1587:
1584:
1579:
1573:
1570:
1565:
1559:
1557:
1553:
1548:
1544:
1539:
1534:
1529:
1524:
1520:
1516:
1512:
1508:
1504:
1497:
1494:
1489:
1485:
1479:
1476:
1471:
1467:
1461:
1458:
1454:
1450:
1445:
1443:
1441:
1437:
1433:
1429:
1424:
1422:
1420:
1416:
1409:
1407:
1405:
1401:
1393:
1391:
1389:
1385:
1381:
1377:
1373:
1369:
1365:
1356:
1354:
1352:
1348:
1340:
1338:
1336:
1332:
1327:
1323:
1319:
1314:
1310:
1302:
1297:
1291:
1287:
1285:
1281:
1277:
1273:
1265:
1263:
1260:
1252:
1250:
1248:
1245:
1241:
1237:
1225:
1220:
1216:
1212:
1209:
1205:
1198:
1196:
1193:
1189:
1185:
1181:
1178:
1174:
1170:
1163:
1161:
1157:
1151:
1147:
1144:
1138:
1136:
1132:
1128:
1122:
1118:
1115:
1111:
1104:
1102:
1098:
1092:
1088:
1085:
1079:
1077:
1073:
1069:
1063:
1059:
1056:
1054:RefSeq (mRNA)
1052:
1045:
1044:
1039:
1035:
1032:
1026:
1025:
1020:
1016:
1013:
1011:
1007:
1000:
999:
994:
990:
987:
981:
980:
975:
971:
968:
966:
962:
955:
954:
949:
945:
942:
936:
935:
930:
926:
923:
921:
917:
914:
911:
909:
906:
902:
899:
895:
891:
884:
880:
875:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
819:
816:
814:
811:
809:
806:
804:
801:
799:
796:
794:
791:
789:
786:
784:
781:
779:
776:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
725:
723:
720:
719:
713:
710:
708:
705:
703:
700:
698:
695:
694:
692:
689:
688:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
623:
621:
618:
617:
614:
613:Gene ontology
610:
606:
594:
589:
585:
578:
573:
570:
568:
564:
556:
551:
540:
536:
532:
528:
524:
520:
517:Gonadal ridge
516:
512:
508:
504:
503:
500:
496:
491:
488:
478:
474:
470:
466:
462:
458:
454:
450:
446:
442:
441:
438:
434:
429:
426:
425:
422:
420:
416:
414:
413:
409:
408:
405:
403:
399:
395:
391:
387:
379:
374:
370:
366:
361:
351:
347:
340:
333:
327:
320:
312:
308:
304:
299:
295:
290:
286:
278:
273:
269:
265:
260:
250:
246:
239:
232:
226:
219:
215:
209:
205:
201:
196:
192:
187:
183:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
135:
130:
123:
118:
113:
102:
100:
96:
92:
88:
84:
80:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
2834:
2700:
2650:
2646:
2609:
2605:
2570:
2566:
2529:
2525:
2499:
2495:
2462:
2458:
2417:
2413:
2386:
2382:
2351:
2347:
2310:
2306:
2279:
2275:
2244:
2240:
2191:
2187:
2158:
2154:
2137:
2133:
2106:
2102:
2052:
2048:
2038:
2003:
1999:
1989:
1954:
1950:
1940:
1926:{{
1918:{{
1860:(3): e9616.
1857:
1853:
1843:
1810:
1806:
1751:
1747:
1737:
1702:
1699:Biochemistry
1698:
1636:
1632:
1622:
1597:
1593:
1586:
1572:
1510:
1506:
1496:
1487:
1478:
1469:
1460:
1397:
1360:
1344:
1341:Inactivation
1306:
1269:
1256:
1243:
1235:
1234:
1160:NP_001344750
1153:
1131:NP_001243242
1127:NP_001243241
1124:
1101:NM_001357821
1094:
1072:NM_001256313
1068:NM_001256312
1065:
1041:
1022:
996:
977:
951:
932:
912:
907:
521:cumulus cell
513:pineal gland
417:
410:
137:External IDs
72:
1957:(1): 1–17.
1404:PTEN (gene)
1388:SCF complex
1335:histone H2B
1322:Thioredoxin
1276:coiled-coil
666:ATP binding
467:optic nerve
463:sural nerve
376:35,179,067
363:34,875,642
275:98,942,827
262:98,371,228
115:Identifiers
2049:Cancer Res
2000:Cell Cycle
1455:, May 2017
1434:, May 2017
1410:References
1313:dimerizing
1303:Activation
1253:Background
421:(ortholog)
158:HomoloGene
1951:Genes Dev
1928:retracted
1920:retracted
1813:: 50–62.
1748:Structure
1298:Mechanism
1280:apoptosis
1266:Structure
1156:NP_062609
1135:NP_006272
1097:NM_019635
1076:NM_006281
898:Orthologs
697:cytoplasm
166:GeneCards
2889:Category
2756:Receptor
2677:17889669
2634:36848574
2626:17538946
2589:17081983
2546:16930133
2516:16510573
2487:27285160
2479:15688006
2459:Oncogene
2450:30879956
2442:15618521
2405:15075335
2370:12554736
2327:11964314
2298:11278283
2263:10840030
2079:20086174
2030:25607644
1981:26728553
1913:37490513
1894:20231902
1854:PLOS ONE
1827:27552481
1778:23972470
1729:27618557
1673:27716844
1614:24468289
1451:–
1430:–
1257:Protein
1208:Wikidata
877:Sources:
459:placenta
2802:MOBKL1B
2797:MOBKL1A
2707:PDBe-KB
2697:UniProt
2668:2821687
2597:7827573
2554:8261982
2422:Bibcode
2414:Science
2335:8728566
2228:8816756
2196:Bibcode
2175:8566796
2146:8274451
2125:7665586
2070:2880716
2021:4353221
1972:4701972
1885:2834758
1862:Bibcode
1835:3930860
1769:3797246
1720:5479320
1664:5055338
1641:Bibcode
1547:8816758
1515:Bibcode
1453:Ensembl
1432:Ensembl
1326:caspase
1272:α-helix
1010:UniProt
965:Ensembl
904:Species
883:QuickGO
707:nucleus
702:cytosol
396:pattern
154:1928487
122:Aliases
2874:RASSF1
2812:Kinase
2702:Q13188
2675:
2665:
2632:
2624:
2595:
2587:
2552:
2544:
2514:
2485:
2477:
2448:
2440:
2403:
2368:
2333:
2325:
2296:
2261:
2226:
2216:
2173:
2144:
2123:
2077:
2067:
2028:
2018:
1979:
1969:
1911:
1907:,
1892:
1882:
1833:
1825:
1776:
1766:
1727:
1717:
1671:
1661:
1612:
1545:
1535:
1378:, and
1259:kinase
1240:enzyme
1238:is an
1194:search
1192:PubMed
1043:Q9JI10
1024:Q13188
920:Entrez
567:BioGPS
533:zygote
509:dermis
254:8q22.2
146:605030
2830:LATS2
2825:LATS1
2787:FRMD6
2630:S2CID
2593:S2CID
2550:S2CID
2483:S2CID
2446:S2CID
2331:S2CID
2307:Blood
2219:38341
1924:with
1831:S2CID
1803:(PDF)
1538:38343
1400:c-Raf
1376:MOB1B
1372:MOB1A
1368:LATS2
1364:LATS1
1347:c-Raf
953:56274
913:Mouse
908:Human
879:Amigo
525:blood
419:Mouse
412:Human
359:Start
294:Mouse
258:Start
191:Human
162:48420
2853:YAP1
2835:STK3
2820:MST1
2792:SAV1
2764:FAT4
2695:for
2673:PMID
2622:PMID
2585:PMID
2567:Cell
2542:PMID
2512:PMID
2475:PMID
2438:PMID
2401:PMID
2366:PMID
2323:PMID
2294:PMID
2259:PMID
2224:PMID
2171:PMID
2155:Gene
2142:PMID
2121:PMID
2075:PMID
2026:PMID
1977:PMID
1909:PMID
1890:PMID
1823:PMID
1774:PMID
1725:PMID
1669:PMID
1610:PMID
1543:PMID
1384:YAP1
1320:and
1318:GLRX
1284:SAV1
1247:gene
1244:STK3
934:6788
402:Bgee
350:Band
311:Chr.
249:Band
208:Chr.
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