302:
279:
176:
201:
1870:
308:
207:
29:
1898:
55:
1475:
Landgrebe J, Dierks T, Schmidt B, von Figura K (2004). "The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new gene family which is conserved from pro- to eukaryotes".
1084:. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional
315:
214:
1869:
1434:"The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment"
1751:"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries"
712:
693:
137:
1786:"Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes"
1967:
1072:
by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a
1943:
1849:
1169:
1151:
1962:
1671:"Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme"
52:
301:
987:
980:
1704:
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".
278:
1239:
1138:
1117:
1348:"Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C(alpha)-formylglycine generating enzyme"
1134:
200:
175:
1113:
117:
314:
213:
307:
206:
1936:
1842:
1189:"The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases"
757:
125:
1593:"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)"
738:
1550:"Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions"
1081:
1929:
1835:
1713:
1402:
1306:
189:
104:
942:
938:
934:
930:
916:
912:
908:
904:
863:
859:
855:
847:
837:
833:
829:
825:
821:
1737:
1377:
1218:
149:
1295:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
963:
920:
884:
851:
1815:
1772:
1729:
1692:
1657:
1622:
1579:
1536:
1493:
1463:
1420:
1369:
1334:
1281:
1210:
97:
45:
1913:
1805:
1797:
1762:
1721:
1682:
1647:
1636:"Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme"
1612:
1604:
1569:
1561:
1526:
1518:
1485:
1453:
1445:
1410:
1359:
1324:
1314:
1271:
1200:
394:
325:
269:
224:
145:
369:
1068:, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a
1717:
1406:
1310:
1187:
Cosma MP, Pepe S, Annunziata I, Newbold RF, Grompe M, Parenti G, Ballabio A (May 2003).
1810:
1785:
1057:
28:
1617:
1592:
1574:
1549:
1531:
1506:
1489:
1458:
1433:
1364:
1347:
1329:
1294:
1205:
1188:
627:
622:
606:
601:
585:
1956:
572:
1381:
1222:
129:
1909:
1741:
387:
166:
1878:: Crystal structure of the paralogue of the human formylglycine generating enzyme
153:
1174:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1156:
National Center for
Biotechnology Information, U.S. National Library of Medicine
470:
1767:
1750:
1065:
286:
183:
133:
1260:"Normalization and subtraction: two approaches to facilitate gene discovery"
1077:
1061:
657:
530:
408:
353:
340:
252:
239:
141:
1819:
1776:
1733:
1696:
1687:
1670:
1661:
1652:
1635:
1626:
1583:
1540:
1497:
1467:
1424:
1373:
1338:
1319:
1214:
1285:
1027:
1022:
1069:
1011:
802:
783:
1725:
1415:
1390:
1801:
1608:
1565:
1522:
1449:
1276:
1259:
1089:
1073:
769:
724:
74:
1085:
1043:
995:
679:
1897:
1669:
Mariappan M, Preusser-Kunze A, Balleininger M, et al. (2005).
642:
638:
1905:
1050:
121:
1831:
1827:
1507:"Functional Proteomics Mapping of a Human Signaling Pathway"
1293:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
1634:
Dickmanns A, Schmidt B, Rudolph MG, et al. (2005).
1346:
Dierks T, Schmidt B, Borissenko LV, et al. (2003).
377:
1917:
1591:
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
1548:
Suzuki Y, Yamashita R, Shirota M, et al. (2004).
1389:
Hillier LW, Fulton RS, Fulton LA, et al. (2003).
1784:
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006).
542:
1505:Colland F, Jacq X, Trouplin V, et al. (2004).
956:
903:
877:
820:
1749:Otsuki T, Ota T, Nishikawa T, et al. (2007).
1432:Clark HF, Gurney AL, Abaya E, et al. (2003).
1130:
1128:
1126:
1109:
1107:
1105:
1240:"Entrez Gene: SUMF2 sulfatase modifying factor 2"
324:
223:
16:Protein-coding gene in the species Homo sapiens
1135:GRCm38: Ensembl release 89: ENSMUSG00000025538
1937:
1843:
8:
1114:GRCh38: Ensembl release 89: ENSG00000129103
1076:with a DUF323 domain that localizes to the
1944:
1930:
1850:
1836:
1828:
900:
817:
653:
568:
365:
264:
161:
63:
1809:
1766:
1686:
1651:
1616:
1573:
1530:
1457:
1414:
1363:
1328:
1318:
1275:
1204:
1064:are only active if they contain a unique
1391:"The DNA sequence of human chromosome 7"
1258:Bonaldo MF, Lennon G, Soares MB (1997).
1234:
1232:
1865:
1101:
623:post-translational protein modification
18:
329:
290:
285:
228:
187:
182:
7:
1894:
1892:
108:, pFGE, sulfatase modifying factor 2
628:glycosphingolipid metabolic process
1916:. You can help Knowledge (XXG) by
953:
874:
793:
774:
748:
729:
703:
684:
547:
465:
403:
382:
14:
1046:that in humans is encoded by the
1896:
1868:
313:
306:
300:
277:
212:
205:
199:
174:
27:
531:More reference expression data
1:
1968:Human chromosome 7 gene stubs
1490:10.1016/S0378-1119(03)00746-7
1365:10.1016/S0092-8674(03)00347-7
1206:10.1016/S0092-8674(03)00348-9
298:
197:
1299:Proc. Natl. Acad. Sci. U.S.A
1040:Sulfatase-modifying factor 2
1963:Genes on human chromosome 7
1092:, have been characterized.
602:endoplasmic reticulum lumen
423:stromal cell of endometrium
1984:
1891:
1863:
1170:"Mouse PubMed Reference:"
1152:"Human PubMed Reference:"
1026:
1021:
1017:
1010:
994:
988:Chr 5: 129.85 – 129.86 Mb
975:
960:
927:
896:
881:
844:
813:
800:
796:
781:
777:
768:
755:
751:
736:
732:
723:
710:
706:
691:
687:
678:
663:
656:
652:
636:
571:
567:
555:
550:
541:
528:
513:medullary collecting duct
477:
468:
415:
406:
376:
368:
364:
347:
334:
297:
276:
267:
263:
246:
233:
196:
173:
164:
160:
115:
112:
102:
95:
90:
71:
66:
49:
44:
39:
35:
26:
21:
1768:10.1093/dnares/12.2.117
981:Chr 7: 56.06 – 56.08 Mb
493:internal carotid artery
489:external carotid artery
1688:10.1074/jbc.M413698200
1653:10.1074/jbc.M414317200
1320:10.1073/pnas.242603899
443:pancreatic ductal cell
1088:, encoding different
1082:endoplasmic reticulum
607:endoplasmic reticulum
447:right adrenal cortex
292:Chromosome 5 (mouse)
190:Chromosome 7 (human)
67:List of PDB id codes
40:Available structures
1726:10.1038/nature04209
1718:2005Natur.437.1173R
1416:10.1038/nature01782
1407:2003Natur.424..157H
1311:2002PNAS...9916899M
439:islet of Langerhans
435:canal of the cervix
1904:This article on a
1802:10.1101/gr.4039406
1609:10.1101/gr.2596504
1566:10.1101/gr.2435604
1523:10.1101/gr.2334104
1450:10.1101/gr.1293003
1277:10.1101/gr.6.9.791
758:ENSMUSG00000025538
616:Biological process
595:Cellular component
579:Molecular function
419:right uterine tube
1925:
1924:
1886:
1885:
1305:(26): 16899–903.
1037:
1036:
1033:
1032:
1006:
1005:
971:
970:
950:
949:
892:
891:
871:
870:
809:
808:
790:
789:
764:
763:
745:
744:
719:
718:
700:
699:
648:
647:
586:metal ion binding
563:
562:
559:
558:
537:
536:
524:
523:
462:
461:
360:
359:
259:
258:
154:SUMF2 - orthologs
86:
85:
82:
81:
50:Ortholog search:
1975:
1946:
1939:
1932:
1900:
1893:
1872:
1852:
1845:
1838:
1829:
1823:
1813:
1780:
1770:
1745:
1712:(7062): 1173–8.
1700:
1690:
1665:
1655:
1630:
1620:
1587:
1577:
1544:
1534:
1501:
1471:
1461:
1428:
1418:
1401:(6945): 157–64.
1385:
1367:
1342:
1332:
1322:
1289:
1279:
1244:
1243:
1236:
1227:
1226:
1208:
1184:
1178:
1177:
1166:
1160:
1159:
1148:
1142:
1132:
1121:
1111:
1019:
1018:
990:
983:
966:
954:
945:
901:
897:RefSeq (protein)
887:
875:
866:
818:
794:
775:
749:
730:
704:
685:
654:
569:
548:
533:
473:
471:Top expressed in
466:
427:body of pancreas
411:
409:Top expressed in
404:
383:
366:
356:
343:
332:
317:
310:
304:
293:
281:
265:
255:
242:
231:
216:
209:
203:
192:
178:
162:
156:
107:
100:
77:
64:
58:
37:
36:
31:
19:
1983:
1982:
1978:
1977:
1976:
1974:
1973:
1972:
1953:
1952:
1951:
1950:
1889:
1887:
1882:
1879:
1873:
1859:
1856:
1826:
1783:
1748:
1703:
1681:(15): 15173–9.
1668:
1646:(15): 15180–7.
1633:
1603:(10B): 2121–7.
1590:
1547:
1504:
1474:
1444:(10): 2265–70.
1431:
1388:
1345:
1292:
1257:
1253:
1251:Further reading
1248:
1247:
1238:
1237:
1230:
1186:
1185:
1181:
1168:
1167:
1163:
1150:
1149:
1145:
1133:
1124:
1112:
1103:
1098:
1086:splice variants
1058:catalytic sites
1028:View/Edit Mouse
1023:View/Edit Human
986:
979:
976:Location (UCSC)
962:
941:
937:
933:
929:
923:
919:
915:
911:
907:
883:
862:
858:
854:
850:
846:
840:
836:
832:
828:
824:
739:ENSG00000129103
632:
611:
590:
529:
520:
515:
511:
507:
505:proximal tubule
503:
499:
497:renal corpuscle
495:
491:
487:
483:
469:
458:
453:
449:
445:
441:
437:
433:
429:
425:
421:
407:
351:
338:
330:
320:
319:
318:
311:
291:
268:Gene location (
250:
237:
229:
219:
218:
217:
210:
188:
165:Gene location (
116:
103:
96:
73:
51:
17:
12:
11:
5:
1981:
1979:
1971:
1970:
1965:
1955:
1954:
1949:
1948:
1941:
1934:
1926:
1923:
1922:
1901:
1884:
1883:
1881:
1880:
1874:
1867:
1864:
1861:
1860:
1857:
1855:
1854:
1847:
1840:
1832:
1825:
1824:
1781:
1746:
1701:
1666:
1631:
1588:
1545:
1517:(7): 1324–32.
1502:
1472:
1429:
1386:
1343:
1290:
1270:(9): 791–806.
1254:
1252:
1249:
1246:
1245:
1228:
1179:
1161:
1143:
1122:
1100:
1099:
1097:
1094:
1035:
1034:
1031:
1030:
1025:
1015:
1014:
1008:
1007:
1004:
1003:
1001:
999:
992:
991:
984:
977:
973:
972:
969:
968:
958:
957:
951:
948:
947:
925:
924:
898:
894:
893:
890:
889:
879:
878:
872:
869:
868:
842:
841:
815:
811:
810:
807:
806:
798:
797:
791:
788:
787:
779:
778:
772:
766:
765:
762:
761:
753:
752:
746:
743:
742:
734:
733:
727:
721:
720:
717:
716:
708:
707:
701:
698:
697:
689:
688:
682:
676:
675:
670:
665:
661:
660:
650:
649:
646:
645:
634:
633:
631:
630:
625:
619:
617:
613:
612:
610:
609:
604:
598:
596:
592:
591:
589:
588:
582:
580:
576:
575:
565:
564:
561:
560:
557:
556:
553:
552:
545:
539:
538:
535:
534:
526:
525:
522:
521:
519:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
478:
475:
474:
463:
460:
459:
457:
456:
452:
451:gastric mucosa
448:
444:
440:
436:
432:
428:
424:
420:
416:
413:
412:
400:
399:
391:
380:
374:
373:
370:RNA expression
362:
361:
358:
357:
349:
345:
344:
336:
333:
328:
322:
321:
312:
305:
299:
295:
294:
289:
283:
282:
274:
273:
261:
260:
257:
256:
248:
244:
243:
235:
232:
227:
221:
220:
211:
204:
198:
194:
193:
186:
180:
179:
171:
170:
158:
157:
114:
110:
109:
101:
93:
92:
88:
87:
84:
83:
80:
79:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1980:
1969:
1966:
1964:
1961:
1960:
1958:
1947:
1942:
1940:
1935:
1933:
1928:
1927:
1921:
1919:
1915:
1911:
1907:
1902:
1899:
1895:
1890:
1877:
1871:
1866:
1862:
1853:
1848:
1846:
1841:
1839:
1834:
1833:
1830:
1821:
1817:
1812:
1807:
1803:
1799:
1795:
1791:
1787:
1782:
1778:
1774:
1769:
1764:
1761:(2): 117–26.
1760:
1756:
1752:
1747:
1743:
1739:
1735:
1731:
1727:
1723:
1719:
1715:
1711:
1707:
1702:
1698:
1694:
1689:
1684:
1680:
1676:
1675:J. Biol. Chem
1672:
1667:
1663:
1659:
1654:
1649:
1645:
1641:
1640:J. Biol. Chem
1637:
1632:
1628:
1624:
1619:
1614:
1610:
1606:
1602:
1598:
1594:
1589:
1585:
1581:
1576:
1571:
1567:
1563:
1560:(9): 1711–8.
1559:
1555:
1551:
1546:
1542:
1538:
1533:
1528:
1524:
1520:
1516:
1512:
1508:
1503:
1499:
1495:
1491:
1487:
1483:
1479:
1473:
1469:
1465:
1460:
1455:
1451:
1447:
1443:
1439:
1435:
1430:
1426:
1422:
1417:
1412:
1408:
1404:
1400:
1396:
1392:
1387:
1383:
1379:
1375:
1371:
1366:
1361:
1358:(4): 435–44.
1357:
1353:
1349:
1344:
1340:
1336:
1331:
1326:
1321:
1316:
1312:
1308:
1304:
1300:
1296:
1291:
1287:
1283:
1278:
1273:
1269:
1265:
1261:
1256:
1255:
1250:
1241:
1235:
1233:
1229:
1224:
1220:
1216:
1212:
1207:
1202:
1199:(4): 445–56.
1198:
1194:
1190:
1183:
1180:
1175:
1171:
1165:
1162:
1157:
1153:
1147:
1144:
1140:
1136:
1131:
1129:
1127:
1123:
1119:
1115:
1110:
1108:
1106:
1102:
1095:
1093:
1091:
1087:
1083:
1079:
1075:
1071:
1067:
1063:
1059:
1054:
1052:
1049:
1045:
1041:
1029:
1024:
1020:
1016:
1013:
1009:
1002:
1000:
997:
993:
989:
985:
982:
978:
974:
967:
965:
959:
955:
952:
946:
944:
940:
936:
932:
926:
922:
918:
914:
910:
906:
902:
899:
895:
888:
886:
880:
876:
873:
867:
865:
861:
857:
853:
849:
843:
839:
835:
831:
827:
823:
819:
816:
814:RefSeq (mRNA)
812:
805:
804:
799:
795:
792:
786:
785:
780:
776:
773:
771:
767:
760:
759:
754:
750:
747:
741:
740:
735:
731:
728:
726:
722:
715:
714:
709:
705:
702:
696:
695:
690:
686:
683:
681:
677:
674:
671:
669:
666:
662:
659:
655:
651:
644:
640:
635:
629:
626:
624:
621:
620:
618:
615:
614:
608:
605:
603:
600:
599:
597:
594:
593:
587:
584:
583:
581:
578:
577:
574:
573:Gene ontology
570:
566:
554:
549:
546:
544:
540:
532:
527:
516:
512:
508:
504:
500:
496:
492:
488:
484:
480:
479:
476:
472:
467:
464:
454:
450:
446:
442:
438:
434:
430:
426:
422:
418:
417:
414:
410:
405:
402:
401:
398:
396:
392:
390:
389:
385:
384:
381:
379:
375:
371:
367:
363:
355:
350:
346:
342:
337:
331:5|5 G1.3
327:
323:
316:
309:
303:
296:
288:
284:
280:
275:
271:
266:
262:
254:
249:
245:
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236:
226:
222:
215:
208:
202:
195:
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185:
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177:
172:
168:
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139:
135:
131:
127:
123:
119:
111:
106:
99:
94:
89:
78:
76:
70:
65:
62:
61:
57:
54:
47:
43:
38:
34:
30:
25:
20:
1918:expanding it
1910:chromosome 7
1903:
1888:
1875:
1796:(1): 55–65.
1793:
1789:
1758:
1754:
1709:
1705:
1678:
1674:
1643:
1639:
1600:
1596:
1557:
1553:
1514:
1510:
1481:
1477:
1441:
1437:
1398:
1394:
1355:
1351:
1302:
1298:
1267:
1263:
1196:
1192:
1182:
1173:
1164:
1155:
1146:
1055:
1047:
1039:
1038:
961:
943:NP_001353578
939:NP_001353577
935:NP_001353576
931:NP_001035933
928:
917:NP_001139805
913:NP_001123541
909:NP_001035935
905:NP_001035934
882:
864:NM_001366649
860:NM_001366648
856:NM_001366647
848:NM_001146333
845:
838:NM_001130070
834:NM_001130069
830:NM_001042470
826:NM_001042469
822:NM_001042468
801:
782:
756:
737:
711:
692:
672:
667:
501:cumulus cell
393:
386:
352:129,864,050
339:129,846,986
113:External IDs
72:
1858:PDB gallery
509:neural tube
431:gallbladder
251:56,080,670
238:56,064,002
91:Identifiers
1957:Categories
1790:Genome Res
1597:Genome Res
1554:Genome Res
1511:Genome Res
1438:Genome Res
1264:Genome Res
1141:, May 2017
1120:, May 2017
1096:References
1066:amino acid
1062:sulfatases
397:(ortholog)
134:HomoloGene
1908:on human
1484:: 47–56.
964:NP_080721
921:NP_056226
885:NM_026445
852:NM_015411
658:Orthologs
142:GeneCards
1820:16344560
1777:16303743
1734:16189514
1697:15708861
1662:15687489
1627:15489334
1584:15342556
1541:15231748
1498:14563551
1468:12975309
1425:12853948
1382:11571659
1374:12757705
1339:12477932
1223:15095377
1215:12757706
1137:–
1116:–
1090:isoforms
1070:cysteine
1012:Wikidata
637:Sources:
485:yolk sac
1811:1356129
1755:DNA Res
1742:4427026
1714:Bibcode
1403:Bibcode
1307:Bibcode
1286:8889548
1139:Ensembl
1118:Ensembl
1080:of the
1074:protein
770:UniProt
725:Ensembl
664:Species
643:QuickGO
517:condyle
372:pattern
130:1915152
98:Aliases
1818:
1808:
1775:
1740:
1732:
1706:Nature
1695:
1660:
1625:
1618:528928
1615:
1582:
1575:515316
1572:
1539:
1532:442148
1529:
1496:
1466:
1459:403697
1456:
1423:
1395:Nature
1380:
1372:
1337:
1330:139241
1327:
1284:
1221:
1213:
1044:enzyme
1042:is an
998:search
996:PubMed
803:Q8BPG6
784:Q8NBJ7
680:Entrez
543:BioGPS
455:rectum
230:7p11.2
122:607940
1912:is a
1738:S2CID
1378:S2CID
1219:S2CID
1078:lumen
1048:SUMF2
713:67902
694:25870
673:Mouse
668:Human
639:Amigo
395:Mouse
388:Human
335:Start
270:Mouse
234:Start
167:Human
146:SUMF2
138:41037
105:SUMF2
22:SUMF2
1914:stub
1906:gene
1876:1y4j
1816:PMID
1773:PMID
1730:PMID
1693:PMID
1658:PMID
1623:PMID
1580:PMID
1537:PMID
1494:PMID
1478:Gene
1464:PMID
1421:PMID
1370:PMID
1352:Cell
1335:PMID
1282:PMID
1211:PMID
1193:Cell
1056:The
1051:gene
481:hand
378:Bgee
326:Band
287:Chr.
225:Band
184:Chr.
118:OMIM
75:1Y4J
56:RCSB
53:PDBe
1806:PMC
1798:doi
1763:doi
1722:doi
1710:437
1683:doi
1679:280
1648:doi
1644:280
1613:PMC
1605:doi
1570:PMC
1562:doi
1527:PMC
1519:doi
1486:doi
1482:316
1454:PMC
1446:doi
1411:doi
1399:424
1360:doi
1356:113
1325:PMC
1315:doi
1272:doi
1201:doi
1197:113
1060:of
551:n/a
348:End
247:End
150:OMA
126:MGI
46:PDB
1959::
1814:.
1804:.
1794:16
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1759:12
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1368:.
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1333:.
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1303:99
1301:.
1297:.
1280:.
1266:.
1262:.
1231:^
1217:.
1209:.
1195:.
1191:.
1172:.
1154:.
1125:^
1104:^
1053:.
641:/
354:bp
341:bp
253:bp
240:bp
148:;
144::
140:;
136::
132:;
128::
124:;
120::
1945:e
1938:t
1931:v
1920:.
1851:e
1844:t
1837:v
1822:.
1800::
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1274::
1268:6
1242:.
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1176:.
1158:.
272:)
169:)
152::
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