194:
171:
200:
1910:
50:
1055:
Chiang PW, Wang SQ, Smithivas P, Song WJ, Crombez E, Akhtar A, Im R, Greenfield J, Ramamoorthy S, Van Keuren M, Blackburn CC, Tsai CH, Kurnit DM (Sep 1996). "Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene".
1444:"DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation"
207:
704:
132:
1653:"Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex"
685:
1951:
1037:
1019:
1155:"DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs"
1809:"Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II"
193:
1409:"FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH"
915:
170:
1610:"Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex"
1091:
1006:
1002:
47:
112:
206:
199:
1944:
1198:"Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro"
1696:"Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties"
747:
120:
1975:
1276:"NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation"
1937:
1112:"Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae"
1514:"Subnuclear Localization of Ku Protein: Functional Association with RNA Polymerase II Elongation Sites"
1970:
1820:
1568:
99:
893:
842:
1891:
1862:"Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila"
1682:
1305:
144:
1557:"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences"
889:
868:
838:
817:
1883:
1848:
1795:
1752:
1717:
1674:
1639:
1596:
1543:
1500:
1465:
1430:
1395:
1348:
1297:
1262:
1227:
1184:
1141:
1073:
92:
40:
1921:
140:
1873:
1838:
1828:
1785:
1777:
1742:
1707:
1664:
1629:
1621:
1586:
1576:
1533:
1525:
1490:
1455:
1420:
1385:
1377:
1338:
1330:
1287:
1252:
1217:
1209:
1174:
1166:
1131:
1123:
1065:
286:
217:
161:
261:
1824:
1572:
1361:
1222:
1197:
1843:
1808:
1790:
1765:
1712:
1695:
1634:
1609:
1591:
1556:
1538:
1513:
1425:
1408:
1292:
1275:
1179:
1154:
1136:
1111:
619:
614:
609:
604:
599:
594:
589:
584:
579:
574:
569:
564:
559:
554:
549:
533:
528:
523:
507:
502:
497:
492:
487:
482:
477:
1964:
1669:
1652:
1529:
1390:
1366:"Domains in the SPT5 Protein That Modulate Its Transcriptional Regulatory Properties"
1365:
1343:
1318:
464:
1895:
1781:
1686:
1625:
1381:
1309:
279:
124:
1042:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1024:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1213:
580:
negative regulation of transcription elongation from RNA polymerase II promoter
362:
1878:
1861:
1766:"Human Spt6 Stimulates Transcription Elongation by RNA Polymerase II In Vitro"
178:
128:
1833:
1731:"Complete sequencing and characterization of 21,243 full-length human cDNAs"
1257:
1240:
649:
245:
232:
136:
1887:
1852:
1799:
1756:
1721:
1678:
1643:
1600:
1581:
1547:
1504:
1495:
1478:
1469:
1460:
1443:
1434:
1399:
1352:
1301:
1266:
1069:
103:, SPT4, SPT4H, SUPT4H, Supt4a, SPT4 homolog, DSIF elongation factor subunit
1334:
1241:"Structure and function of the human transcription elongation factor DSIF"
1231:
1188:
1145:
1127:
1077:
955:
950:
1170:
939:
792:
773:
1917:
971:
759:
716:
1909:
610:
regulation of transcription elongation from RNA polymerase II promoter
69:
923:
671:
148:
1747:
1730:
1092:"Entrez Gene: SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)"
634:
630:
1110:
Hartzog GA, Basrai MA, Ricupero-Hovasse SL, et al. (1996).
978:
116:
1479:"A highly purified RNA polymerase II elongation control system"
1319:"Tat-SF1 Protein Associates with RAP30 and Human SPT5 Proteins"
595:
positive regulation of DNA-templated transcription, elongation
590:
negative regulation of DNA-templated transcription, elongation
422:
300:
1555:
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
600:
positive regulation of transcription by RNA polymerase II
570:
negative regulation of transcription by RNA polymerase II
565:
transcription elongation from RNA polymerase II promoter
269:
1925:
1860:
Jennings BH, Shah S, Yamaguchi Y, et al. (2005).
1407:
Wada T, Orphanides G, Hasegawa J, et al. (2000).
1239:
Yamaguchi Y, Wada T, Watanabe D, et al. (1999).
434:
1477:
Renner DB, Yamaguchi Y, Wada T, et al. (2001).
1608:Narita T, Yamaguchi Y, Yano K, et al. (2003).
1274:Yamaguchi Y, Takagi T, Wada T, et al. (1999).
1196:Wada T, Takagi T, Yamaguchi Y, et al. (1999).
1153:Wada T, Takagi T, Yamaguchi Y, et al. (1998).
882:
861:
831:
810:
409:
dentate gyrus of hippocampal formation granule cell
1729:Ota T, Suzuki Y, Nishikawa T, et al. (2004).
998:
996:
994:
1694:Kwak YT, Guo J, Prajapati S, et al. (2003).
1317:Kim JB, Yamaguchi Y, Wada T, et al. (1999).
216:
1764:Endoh M, Zhu W, Hasegawa J, et al. (2004).
1651:Kim DK, Inukai N, Yamada T, et al. (2004).
560:regulation of transcription by RNA polymerase II
16:Protein-coding gene in the species Homo sapiens
1807:Mandal SS, Chu C, Wada T, et al. (2004).
1003:GRCm38: Ensembl release 89: ENSMUSG00000020485
1945:
8:
1952:
1938:
645:
620:positive regulation of viral transcription
555:regulation of transcription, DNA-templated
460:
257:
156:
58:
1877:
1842:
1832:
1789:
1746:
1711:
1668:
1633:
1590:
1580:
1537:
1494:
1459:
1424:
1389:
1342:
1291:
1256:
1221:
1178:
1135:
478:DNA-binding transcription factor activity
990:
18:
221:
182:
177:
7:
1906:
1904:
968:Transcription elongation factor SPT4
498:protein heterodimerization activity
1924:. You can help Knowledge (XXG) by
879:
858:
828:
807:
783:
764:
738:
721:
695:
676:
575:transcription by RNA polymerase II
439:
357:
295:
274:
14:
974:that in humans is encoded by the
503:RNA polymerase II complex binding
1908:
1670:10.1046/j.1365-2443.2003.00638.x
1530:10.1128/MCB.22.22.8088-8099.2002
205:
198:
192:
169:
1782:10.1128/MCB.24.8.3324-3336.2004
1626:10.1128/MCB.23.6.1863-1873.2003
1382:10.1128/MCB.20.9.2970-2983.2000
423:More reference expression data
1:
1713:10.1016/S1097-2765(03)00101-1
1426:10.1016/S1097-2765(00)80272-5
1293:10.1016/S0092-8674(00)80713-8
190:
1813:Proc. Natl. Acad. Sci. U.S.A
1561:Proc. Natl. Acad. Sci. U.S.A
585:transcription, DNA-templated
508:single-stranded RNA binding
327:stromal cell of endometrium
1992:
1903:
1360:Ivanov D, Kwak YT, Guo J,
1879:10.1016/j.cub.2004.08.066
1442:Ping YH, Rana TM (2001).
1038:"Mouse PubMed Reference:"
1020:"Human PubMed Reference:"
954:
949:
945:
938:
922:
905:
886:
865:
854:
835:
814:
803:
790:
786:
771:
767:
758:
745:
741:
728:
724:
715:
702:
698:
683:
679:
670:
655:
648:
644:
628:
463:
459:
447:
442:
433:
420:
369:
360:
307:
298:
268:
260:
256:
239:
226:
189:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1214:10.1093/emboj/17.24.7395
916:Chr 11: 87.63 – 87.63 Mb
1834:10.1073/pnas.0401493101
1512:Mo X, Dynan WS (2002).
1258:10.1074/jbc.274.12.8085
1920:-related article is a
1582:10.1073/pnas.242603899
1496:10.1074/jbc.M104967200
1461:10.1074/jbc.M006130200
1070:10.1006/geno.1996.0299
615:chromatin organization
401:neural layer of retina
1335:10.1128/mcb.19.9.5960
1128:10.1128/MCB.16.6.2848
184:Chromosome 11 (mouse)
1171:10.1101/gad.12.3.343
550:chromatin remodeling
223:11 C|11 52.2 cM
62:List of PDB id codes
35:Available structures
1825:2004PNAS..101.7572M
1573:2002PNAS...9916899M
347:right adrenal gland
339:ganglionic eminence
335:islet of Langerhans
149:SUPT4H1 - orthologs
748:ENSMUSG00000020485
543:Biological process
517:Cellular component
471:Molecular function
1933:
1932:
1567:(26): 16899–903.
965:
964:
961:
960:
934:
933:
901:
900:
876:
875:
850:
849:
825:
824:
799:
798:
780:
779:
754:
753:
735:
734:
711:
710:
692:
691:
640:
639:
488:metal ion binding
455:
454:
451:
450:
429:
428:
416:
415:
354:
353:
343:bone marrow cells
252:
251:
81:
80:
77:
76:
45:Ortholog search:
1983:
1954:
1947:
1940:
1912:
1905:
1899:
1881:
1856:
1846:
1836:
1803:
1793:
1760:
1750:
1725:
1715:
1690:
1672:
1647:
1637:
1604:
1594:
1584:
1551:
1541:
1508:
1498:
1473:
1463:
1438:
1428:
1403:
1393:
1356:
1346:
1313:
1295:
1270:
1260:
1235:
1225:
1208:(24): 7395–403.
1192:
1182:
1149:
1139:
1096:
1095:
1088:
1082:
1081:
1052:
1046:
1045:
1034:
1028:
1027:
1016:
1010:
1000:
947:
946:
918:
911:
896:
880:
871:
859:
855:RefSeq (protein)
845:
829:
820:
808:
784:
765:
739:
722:
696:
677:
646:
483:zinc ion binding
461:
440:
425:
393:ventricular zone
365:
363:Top expressed in
358:
303:
301:Top expressed in
296:
275:
258:
248:
235:
224:
209:
202:
196:
185:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
1991:
1990:
1986:
1985:
1984:
1982:
1981:
1980:
1961:
1960:
1959:
1958:
1902:
1859:
1806:
1770:Mol. Cell. Biol
1763:
1728:
1693:
1650:
1614:Mol. Cell. Biol
1607:
1554:
1524:(22): 8088–99.
1518:Mol. Cell. Biol
1511:
1489:(45): 42601–9.
1476:
1454:(16): 12951–8.
1441:
1406:
1370:Mol. Cell. Biol
1359:
1323:Mol. Cell. Biol
1316:
1273:
1251:(12): 8085–92.
1238:
1195:
1152:
1116:Mol. Cell. Biol
1109:
1105:
1103:Further reading
1100:
1099:
1090:
1089:
1085:
1054:
1053:
1049:
1036:
1035:
1031:
1018:
1017:
1013:
1001:
992:
987:
956:View/Edit Mouse
951:View/Edit Human
914:
909:
906:Location (UCSC)
892:
888:
867:
841:
837:
816:
624:
605:mRNA processing
538:
512:
493:protein binding
421:
412:
407:
403:
399:
395:
391:
387:
383:
379:
375:
361:
350:
345:
341:
337:
333:
329:
325:
321:
319:Achilles tendon
317:
313:
299:
243:
230:
222:
212:
211:
210:
203:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
1989:
1987:
1979:
1978:
1973:
1963:
1962:
1957:
1956:
1949:
1942:
1934:
1931:
1930:
1913:
1901:
1900:
1872:(18): 1680–4.
1857:
1819:(20): 7572–7.
1804:
1776:(8): 3324–36.
1761:
1748:10.1038/ng1285
1726:
1706:(4): 1055–66.
1691:
1648:
1620:(6): 1863–73.
1605:
1552:
1509:
1474:
1439:
1419:(6): 1067–72.
1404:
1376:(9): 2970–83.
1357:
1314:
1271:
1236:
1193:
1150:
1122:(6): 2848–56.
1106:
1104:
1101:
1098:
1097:
1083:
1047:
1029:
1011:
989:
988:
986:
983:
963:
962:
959:
958:
953:
943:
942:
936:
935:
932:
931:
929:
927:
920:
919:
912:
907:
903:
902:
899:
898:
884:
883:
877:
874:
873:
863:
862:
856:
852:
851:
848:
847:
833:
832:
826:
823:
822:
812:
811:
805:
801:
800:
797:
796:
788:
787:
781:
778:
777:
769:
768:
762:
756:
755:
752:
751:
743:
742:
736:
733:
732:
726:
725:
719:
713:
712:
709:
708:
700:
699:
693:
690:
689:
681:
680:
674:
668:
667:
662:
657:
653:
652:
642:
641:
638:
637:
626:
625:
623:
622:
617:
612:
607:
602:
597:
592:
587:
582:
577:
572:
567:
562:
557:
552:
546:
544:
540:
539:
537:
536:
531:
526:
520:
518:
514:
513:
511:
510:
505:
500:
495:
490:
485:
480:
474:
472:
468:
467:
457:
456:
453:
452:
449:
448:
445:
444:
437:
431:
430:
427:
426:
418:
417:
414:
413:
411:
410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
370:
367:
366:
355:
352:
351:
349:
348:
344:
340:
336:
332:
328:
324:
320:
316:
312:
308:
305:
304:
292:
291:
283:
272:
266:
265:
262:RNA expression
254:
253:
250:
249:
241:
237:
236:
228:
225:
220:
214:
213:
204:
197:
191:
187:
186:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1988:
1977:
1976:Protein stubs
1974:
1972:
1969:
1968:
1966:
1955:
1950:
1948:
1943:
1941:
1936:
1935:
1929:
1927:
1923:
1919:
1914:
1911:
1907:
1897:
1893:
1889:
1885:
1880:
1875:
1871:
1867:
1863:
1858:
1854:
1850:
1845:
1840:
1835:
1830:
1826:
1822:
1818:
1814:
1810:
1805:
1801:
1797:
1792:
1787:
1783:
1779:
1775:
1771:
1767:
1762:
1758:
1754:
1749:
1744:
1740:
1736:
1732:
1727:
1723:
1719:
1714:
1709:
1705:
1701:
1697:
1692:
1688:
1684:
1680:
1676:
1671:
1666:
1662:
1658:
1654:
1649:
1645:
1641:
1636:
1631:
1627:
1623:
1619:
1615:
1611:
1606:
1602:
1598:
1593:
1588:
1583:
1578:
1574:
1570:
1566:
1562:
1558:
1553:
1549:
1545:
1540:
1535:
1531:
1527:
1523:
1519:
1515:
1510:
1506:
1502:
1497:
1492:
1488:
1484:
1483:J. Biol. Chem
1480:
1475:
1471:
1467:
1462:
1457:
1453:
1449:
1448:J. Biol. Chem
1445:
1440:
1436:
1432:
1427:
1422:
1418:
1414:
1410:
1405:
1401:
1397:
1392:
1387:
1383:
1379:
1375:
1371:
1367:
1363:
1358:
1354:
1350:
1345:
1340:
1336:
1332:
1329:(9): 5960–8.
1328:
1324:
1320:
1315:
1311:
1307:
1303:
1299:
1294:
1289:
1285:
1281:
1277:
1272:
1268:
1264:
1259:
1254:
1250:
1246:
1245:J. Biol. Chem
1242:
1237:
1233:
1229:
1224:
1219:
1215:
1211:
1207:
1203:
1199:
1194:
1190:
1186:
1181:
1176:
1172:
1168:
1165:(3): 343–56.
1164:
1160:
1156:
1151:
1147:
1143:
1138:
1133:
1129:
1125:
1121:
1117:
1113:
1108:
1107:
1102:
1093:
1087:
1084:
1079:
1075:
1071:
1067:
1064:(3): 368–75.
1063:
1059:
1051:
1048:
1043:
1039:
1033:
1030:
1025:
1021:
1015:
1012:
1008:
1004:
999:
997:
995:
991:
984:
982:
980:
977:
973:
969:
957:
952:
948:
944:
941:
937:
930:
928:
925:
921:
917:
913:
908:
904:
897:
895:
891:
885:
881:
878:
872:
870:
864:
860:
857:
853:
846:
844:
840:
834:
830:
827:
821:
819:
813:
809:
806:
804:RefSeq (mRNA)
802:
795:
794:
789:
785:
782:
776:
775:
770:
766:
763:
761:
757:
750:
749:
744:
740:
737:
731:
727:
723:
720:
718:
714:
707:
706:
701:
697:
694:
688:
687:
682:
678:
675:
673:
669:
666:
663:
661:
658:
654:
651:
647:
643:
636:
632:
627:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
591:
588:
586:
583:
581:
578:
576:
573:
571:
568:
566:
563:
561:
558:
556:
553:
551:
548:
547:
545:
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541:
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465:Gene ontology
462:
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106:
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94:
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84:
73:
71:
65:
60:
57:
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52:
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42:
38:
33:
29:
25:
20:
1926:expanding it
1915:
1869:
1865:
1816:
1812:
1773:
1769:
1738:
1734:
1703:
1699:
1663:(4): 371–8.
1660:
1656:
1617:
1613:
1564:
1560:
1521:
1517:
1486:
1482:
1451:
1447:
1416:
1412:
1373:
1369:
1326:
1322:
1286:(1): 41–51.
1283:
1279:
1248:
1244:
1205:
1201:
1162:
1158:
1119:
1115:
1086:
1061:
1057:
1050:
1041:
1032:
1023:
1014:
975:
967:
966:
894:NP_001342682
887:
866:
843:NM_001355753
836:
815:
791:
772:
746:
729:
703:
684:
664:
659:
529:DSIF complex
397:right kidney
285:
278:
108:External IDs
67:
1971:Human genes
1741:(1): 40–5.
1657:Genes Cells
524:nucleoplasm
373:granulocyte
323:bone marrow
244:87,634,449
231:87,628,378
86:Identifiers
1965:Categories
1866:Curr. Biol
1735:Nat. Genet
1009:, May 2017
985:References
331:lymph node
289:(ortholog)
129:HomoloGene
1700:Mol. Cell
1413:Mol. Cell
1362:Gaynor RB
1159:Genes Dev
890:NP_033322
869:NP_003159
839:NM_009296
818:NM_003168
650:Orthologs
137:GeneCards
1896:18780732
1888:15380072
1853:15136722
1800:15060154
1757:14702039
1722:12718890
1687:42100130
1679:12653964
1644:12612062
1601:12477932
1548:12391174
1505:11553615
1470:11112772
1435:10912001
1400:10757782
1364:(2000).
1353:10454543
1310:16855257
1302:10199401
1267:10075709
1058:Genomics
1005:–
940:Wikidata
629:Sources:
389:yolk sac
311:monocyte
1918:protein
1821:Bibcode
1569:Bibcode
1232:9857195
1223:1171084
1189:9450929
1146:8649394
1078:8786137
1007:Ensembl
976:SUPT4H1
972:protein
760:UniProt
717:Ensembl
656:Species
635:QuickGO
534:nucleus
264:pattern
141:SUPT4H1
100:SUPT4H1
93:Aliases
22:SUPT4H1
1894:
1886:
1851:
1844:419647
1841:
1798:
1791:381665
1788:
1755:
1720:
1685:
1677:
1642:
1635:149481
1632:
1599:
1592:139241
1589:
1546:
1539:134733
1536:
1503:
1468:
1433:
1398:
1388:
1351:
1341:
1308:
1300:
1265:
1230:
1220:
1202:EMBO J
1187:
1180:316480
1177:
1144:
1137:231277
1134:
1076:
926:search
924:PubMed
793:P63271
774:P63272
672:Entrez
435:BioGPS
385:embryo
381:embryo
377:morula
125:107416
117:603555
1916:This
1892:S2CID
1683:S2CID
1391:85557
1344:84462
1306:S2CID
970:is a
705:20922
665:Mouse
660:Human
631:Amigo
315:blood
287:Mouse
280:Human
227:Start
162:Mouse
133:68303
1922:stub
1884:PMID
1849:PMID
1796:PMID
1753:PMID
1718:PMID
1675:PMID
1640:PMID
1597:PMID
1544:PMID
1501:PMID
1466:PMID
1431:PMID
1396:PMID
1349:PMID
1298:PMID
1280:Cell
1263:PMID
1228:PMID
1185:PMID
1142:PMID
1074:PMID
979:gene
686:6827
270:Bgee
218:Band
179:Chr.
113:OMIM
70:3H7H
51:RCSB
48:PDBe
1874:doi
1839:PMC
1829:doi
1817:101
1786:PMC
1778:doi
1743:doi
1708:doi
1665:doi
1630:PMC
1622:doi
1587:PMC
1577:doi
1534:PMC
1526:doi
1491:doi
1487:276
1456:doi
1452:276
1421:doi
1386:PMC
1378:doi
1339:PMC
1331:doi
1288:doi
1253:doi
1249:274
1218:PMC
1210:doi
1175:PMC
1167:doi
1132:PMC
1124:doi
1066:doi
910:n/a
730:n/a
443:n/a
405:lip
240:End
145:OMA
121:MGI
41:PDB
1967::
1890:.
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1870:14
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1200:.
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1163:12
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1140:.
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1120:16
1118:.
1114:.
1072:.
1062:34
1060:.
1040:.
1022:.
993:^
981:.
633:/
246:bp
233:bp
143:;
139::
135:;
131::
127:;
123::
119:;
115::
1953:e
1946:t
1939:v
1928:.
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1802:.
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164:)
147::
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