306:
283:
180:
205:
1154:
which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. Its function may include recruitment of actin and other cytoskeletal proteins into specialized structures at the plasma membrane and in the nuclei of growing cells. Two transcript variants encoding different isoforms of supervillin have been described.
564:
557:
312:
211:
29:
1821:
1153:
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins,
55:
1438:
Pope RK, Pestonjamasp KN, Smith KP, Wulfkuhle JD, Strassel CP, Lawrence JB, Luna EJ (Sep 1998). "Cloning, characterization, and chromosomal localization of human supervillin (SVIL)".
1725:
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004).
319:
218:
812:
141:
793:
1727:"Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization"
1890:
1866:
1247:
1885:
1229:
305:
1072:
282:
1079:
1317:
1331:
Ghoshdastider U, Popp D, Burtnick LD, Robinson RC (Nov 2013). "The expanding superfamily of gelsolin homology domain proteins".
1216:
1195:
204:
179:
1212:
1594:"Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton"
52:
1469:"Domain analysis of supervillin, an F-actin bundling plasma membrane protein with functional nuclear localization signals"
1191:
121:
1163:
318:
217:
1859:
311:
210:
857:
129:
1672:
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004).
1267:"Supervillin (p205): A novel membrane-associated, F-actin-binding protein in the villin/gelsolin superfamily"
838:
1852:
1637:
Chen Y, Takizawa N, Crowley JL, Oh SW, Gatto CL, Kambara T, Sato O, Li XD, Ikebe M, Luna EJ (Nov 2003).
193:
1685:
1552:
1387:
108:
1055:
1051:
1047:
1037:
1033:
1029:
1021:
998:
994:
968:
939:
935:
1799:
1756:
1356:
153:
1025:
1006:
1002:
964:
960:
931:
927:
1467:
Wulfkuhle JD, Donina IE, Stark NH, Pope RK, Pestonjamasp KN, Niswonger ML, Luna EJ (Jul 1999).
1791:
1748:
1713:
1660:
1625:
1580:
1527:
1484:
1455:
1415:
1348:
1296:
1167:
101:
45:
1836:
1781:
1738:
1703:
1693:
1650:
1615:
1605:
1570:
1560:
1517:
1509:
1476:
1447:
1405:
1395:
1340:
1286:
1278:
563:
556:
398:
329:
273:
228:
1541:"Supervillin associates with androgen receptor and modulates its transcriptional activity"
1376:"Supervillin associates with androgen receptor and modulates its transcriptional activity"
373:
149:
1689:
1556:
1391:
1291:
1266:
1708:
1673:
1575:
1540:
1522:
1497:
1410:
1375:
727:
722:
717:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
631:
615:
610:
605:
28:
1879:
1832:
1360:
592:
133:
1803:
1770:"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks"
1760:
391:
170:
157:
1252:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1234:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1786:
1769:
1768:
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006).
1678:
Proceedings of the
National Academy of Sciences of the United States of America
1592:
Oh SW, Pope RK, Smith KP, Crowley JL, Nebl T, Lawrence JB, Luna EJ (Jun 2003).
1545:
Proceedings of the
National Academy of Sciences of the United States of America
1513:
1468:
1380:
Proceedings of the
National Academy of Sciences of the United States of America
474:
1743:
1726:
290:
187:
137:
1698:
1480:
757:
534:
412:
357:
344:
256:
243:
145:
1795:
1752:
1717:
1664:
1655:
1638:
1629:
1584:
1565:
1531:
1488:
1451:
1419:
1400:
1352:
1282:
1498:"Proteomic and functional evidence for a P2X7 receptor signalling complex"
1459:
1300:
1119:
1114:
1103:
902:
883:
1135:
869:
824:
1620:
1610:
1593:
78:
74:
1344:
1087:
779:
1820:
1674:"Large-scale characterization of HeLa cell nuclear phosphoproteins"
742:
738:
1828:
1142:
125:
1496:
Kim M, Jiang LH, Wilson HL, North RA, Surprenant A (Nov 2001).
572:
1265:
Pestonjamasp KN, Pope RK, Wulfkuhle JD, Luna EJ (Dec 1997).
381:
1840:
1639:"F-actin and myosin II binding domains in supervillin"
546:
1020:
987:
953:
920:
1208:
1206:
1204:
1187:
1185:
1183:
1539:Ting HJ, Yeh S, Nishimura K, Chang C (Jan 2002).
1374:Ting HJ, Yeh S, Nishimura K, Chang C (Jan 2002).
328:
227:
16:Protein-coding gene in the species Homo sapiens
1213:GRCm38: Ensembl release 89: ENSMUSG00000024236
1860:
8:
1192:GRCh38: Ensembl release 89: ENSG00000197321
1867:
1853:
1017:
753:
588:
427:Skeletal muscle tissue of rectus abdominis
369:
268:
165:
63:
1785:
1742:
1707:
1697:
1654:
1619:
1609:
1574:
1564:
1521:
1409:
1399:
1290:
1312:
1310:
439:Skeletal muscle tissue of biceps brachii
1179:
18:
333:
294:
289:
232:
191:
186:
7:
1817:
1815:
1643:The Journal of Biological Chemistry
1839:. You can help Knowledge (XXG) by
984:
950:
917:
893:
874:
848:
829:
803:
784:
723:skeletal muscle tissue development
718:positive regulation of cytokinesis
551:
469:
407:
386:
14:
1138:that in humans is encoded by the
1819:
562:
555:
317:
310:
304:
281:
216:
209:
203:
178:
27:
1318:"Entrez Gene: SVIL supervillin"
1891:Human chromosome 10 gene stubs
1475:. 112 ( Pt 13) (13): 2125–36.
573:More reference expression data
535:More reference expression data
1:
302:
201:
1886:Genes on human chromosome 10
1271:The Journal of Cell Biology
1907:
1814:
1787:10.1016/j.cell.2006.09.026
513:sternocleidomastoid muscle
1744:10.1016/j.cub.2004.07.051
1248:"Mouse PubMed Reference:"
1230:"Human PubMed Reference:"
1118:
1113:
1109:
1102:
1086:
1067:
1044:
991:
980:
957:
924:
913:
900:
896:
881:
877:
868:
855:
851:
836:
832:
823:
810:
806:
791:
787:
778:
763:
756:
752:
736:
728:cytoskeleton organization
591:
587:
570:
554:
545:
532:
481:
472:
419:
410:
380:
372:
368:
351:
338:
301:
280:
271:
267:
250:
237:
200:
177:
168:
164:
119:
116:
106:
99:
94:
71:
66:
49:
44:
39:
35:
26:
21:
1514:10.1093/emboj/20.22.6347
1073:Chr 10: 29.46 – 29.74 Mb
451:tibialis anterior muscle
1699:10.1073/pnas.0404720101
1598:Journal of Cell Science
1481:10.1242/jcs.112.13.2125
1473:Journal of Cell Science
1162:SVIL has been shown to
493:vastus lateralis muscle
431:vastus lateralis muscle
1656:10.1074/jbc.M305311200
1566:10.1073/pnas.022469899
1452:10.1006/geno.1998.5466
1401:10.1073/pnas.022469899
1283:10.1083/jcb.139.5.1255
1080:Chr 18: 4.92 – 5.12 Mb
606:actin filament binding
489:triceps brachii muscle
637:microtubule minus-end
296:Chromosome 18 (mouse)
194:Chromosome 10 (human)
447:gastrocnemius muscle
112:, supervillin, MFM10
67:List of PDB id codes
40:Available structures
1690:2004PNAS..10112130B
1557:2002PNAS...99..661T
1392:2002PNAS...99..661T
1827:This article on a
1604:(Pt 11): 2261–75.
858:ENSMUSG00000024236
711:Biological process
697:actin cytoskeleton
625:Cellular component
599:Molecular function
455:thoracic diaphragm
1848:
1847:
1649:(46): 46094–106.
1611:10.1242/jcs.00422
1168:Androgen receptor
1129:
1128:
1125:
1124:
1098:
1097:
1063:
1062:
1014:
1013:
976:
975:
947:
946:
909:
908:
890:
889:
864:
863:
845:
844:
819:
818:
800:
799:
748:
747:
583:
582:
579:
578:
541:
540:
528:
527:
466:
465:
364:
363:
263:
262:
90:
89:
86:
85:
50:Ortholog search:
1898:
1869:
1862:
1855:
1823:
1816:
1807:
1789:
1764:
1746:
1721:
1711:
1701:
1668:
1658:
1633:
1623:
1613:
1588:
1578:
1568:
1535:
1525:
1502:The EMBO Journal
1492:
1463:
1424:
1423:
1413:
1403:
1371:
1365:
1364:
1345:10.1002/cm.21149
1328:
1322:
1321:
1314:
1305:
1304:
1294:
1262:
1256:
1255:
1244:
1238:
1237:
1226:
1220:
1210:
1199:
1189:
1111:
1110:
1082:
1075:
1058:
1018:
1009:
985:
981:RefSeq (protein)
971:
951:
942:
918:
894:
875:
849:
830:
804:
785:
754:
589:
575:
566:
559:
552:
537:
505:digastric muscle
477:
475:Top expressed in
470:
415:
413:Top expressed in
408:
387:
370:
360:
347:
336:
321:
314:
308:
297:
285:
269:
259:
246:
235:
220:
213:
207:
196:
182:
166:
160:
158:SVIL - orthologs
111:
104:
81:
64:
58:
37:
36:
31:
19:
1906:
1905:
1901:
1900:
1899:
1897:
1896:
1895:
1876:
1875:
1874:
1873:
1812:
1810:
1767:
1737:(16): 1436–50.
1731:Current Biology
1724:
1684:(33): 12130–5.
1671:
1636:
1591:
1538:
1508:(22): 6347–58.
1495:
1466:
1437:
1433:
1431:Further reading
1428:
1427:
1373:
1372:
1368:
1330:
1329:
1325:
1316:
1315:
1308:
1264:
1263:
1259:
1246:
1245:
1241:
1228:
1227:
1223:
1211:
1202:
1190:
1181:
1176:
1160:
1151:
1120:View/Edit Mouse
1115:View/Edit Human
1078:
1071:
1068:Location (UCSC)
1054:
1050:
1046:
1040:
1036:
1032:
1028:
1024:
1005:
1001:
997:
993:
967:
963:
959:
938:
934:
930:
926:
839:ENSG00000197321
732:
706:
667:cleavage furrow
657:cell projection
652:plasma membrane
620:
616:protein binding
571:
561:
560:
533:
524:
519:
515:
511:
509:temporal muscle
507:
503:
499:
497:right ventricle
495:
491:
487:
473:
462:
457:
453:
449:
445:
441:
437:
433:
429:
425:
411:
355:
342:
334:
324:
323:
322:
315:
295:
272:Gene location (
254:
241:
233:
223:
222:
221:
214:
192:
169:Gene location (
120:
107:
100:
73:
51:
17:
12:
11:
5:
1904:
1902:
1894:
1893:
1888:
1878:
1877:
1872:
1871:
1864:
1857:
1849:
1846:
1845:
1824:
1809:
1808:
1765:
1722:
1669:
1634:
1589:
1536:
1493:
1464:
1434:
1432:
1429:
1426:
1425:
1366:
1339:(11): 775–95.
1323:
1306:
1277:(5): 1255–69.
1257:
1239:
1221:
1200:
1178:
1177:
1175:
1172:
1159:
1156:
1150:
1147:
1127:
1126:
1123:
1122:
1117:
1107:
1106:
1100:
1099:
1096:
1095:
1093:
1091:
1084:
1083:
1076:
1069:
1065:
1064:
1061:
1060:
1042:
1041:
1015:
1012:
1011:
989:
988:
982:
978:
977:
974:
973:
955:
954:
948:
945:
944:
922:
921:
915:
911:
910:
907:
906:
898:
897:
891:
888:
887:
879:
878:
872:
866:
865:
862:
861:
853:
852:
846:
843:
842:
834:
833:
827:
821:
820:
817:
816:
808:
807:
801:
798:
797:
789:
788:
782:
776:
775:
770:
765:
761:
760:
750:
749:
746:
745:
734:
733:
731:
730:
725:
720:
714:
712:
708:
707:
705:
704:
699:
694:
692:focal adhesion
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
634:
628:
626:
622:
621:
619:
618:
613:
608:
602:
600:
596:
595:
585:
584:
581:
580:
577:
576:
568:
567:
549:
543:
542:
539:
538:
530:
529:
526:
525:
523:
522:
518:
514:
510:
506:
502:
498:
494:
490:
486:
482:
479:
478:
467:
464:
463:
461:
460:
459:body of tongue
456:
452:
448:
444:
443:deltoid muscle
440:
436:
435:biceps brachii
432:
428:
424:
420:
417:
416:
404:
403:
395:
384:
378:
377:
374:RNA expression
366:
365:
362:
361:
353:
349:
348:
340:
337:
332:
326:
325:
316:
309:
303:
299:
298:
293:
287:
286:
278:
277:
265:
264:
261:
260:
252:
248:
247:
239:
236:
231:
225:
224:
215:
208:
202:
198:
197:
190:
184:
183:
175:
174:
162:
161:
118:
114:
113:
105:
97:
96:
92:
91:
88:
87:
84:
83:
69:
68:
60:
59:
48:
42:
41:
33:
32:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1903:
1892:
1889:
1887:
1884:
1883:
1881:
1870:
1865:
1863:
1858:
1856:
1851:
1850:
1844:
1842:
1838:
1834:
1833:chromosome 10
1830:
1825:
1822:
1818:
1813:
1805:
1801:
1797:
1793:
1788:
1783:
1780:(3): 635–48.
1779:
1775:
1771:
1766:
1762:
1758:
1754:
1750:
1745:
1740:
1736:
1732:
1728:
1723:
1719:
1715:
1710:
1705:
1700:
1695:
1691:
1687:
1683:
1679:
1675:
1670:
1666:
1662:
1657:
1652:
1648:
1644:
1640:
1635:
1631:
1627:
1622:
1617:
1612:
1607:
1603:
1599:
1595:
1590:
1586:
1582:
1577:
1572:
1567:
1562:
1558:
1554:
1550:
1546:
1542:
1537:
1533:
1529:
1524:
1519:
1515:
1511:
1507:
1503:
1499:
1494:
1490:
1486:
1482:
1478:
1474:
1470:
1465:
1461:
1457:
1453:
1449:
1446:(3): 342–51.
1445:
1441:
1436:
1435:
1430:
1421:
1417:
1412:
1407:
1402:
1397:
1393:
1389:
1385:
1381:
1377:
1370:
1367:
1362:
1358:
1354:
1350:
1346:
1342:
1338:
1334:
1327:
1324:
1319:
1313:
1311:
1307:
1302:
1298:
1293:
1288:
1284:
1280:
1276:
1272:
1268:
1261:
1258:
1253:
1249:
1243:
1240:
1235:
1231:
1225:
1222:
1218:
1214:
1209:
1207:
1205:
1201:
1197:
1193:
1188:
1186:
1184:
1180:
1173:
1171:
1169:
1165:
1157:
1155:
1148:
1146:
1144:
1141:
1137:
1133:
1121:
1116:
1112:
1108:
1105:
1101:
1094:
1092:
1089:
1085:
1081:
1077:
1074:
1070:
1066:
1059:
1057:
1053:
1049:
1043:
1039:
1035:
1031:
1027:
1023:
1019:
1016:
1010:
1008:
1004:
1000:
996:
990:
986:
983:
979:
972:
970:
966:
962:
956:
952:
949:
943:
941:
937:
933:
929:
923:
919:
916:
914:RefSeq (mRNA)
912:
905:
904:
899:
895:
892:
886:
885:
880:
876:
873:
871:
867:
860:
859:
854:
850:
847:
841:
840:
835:
831:
828:
826:
822:
815:
814:
809:
805:
802:
796:
795:
790:
786:
783:
781:
777:
774:
771:
769:
766:
762:
759:
755:
751:
744:
740:
735:
729:
726:
724:
721:
719:
716:
715:
713:
710:
709:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
647:cell junction
645:
643:
640:
638:
635:
633:
630:
629:
627:
624:
623:
617:
614:
612:
611:actin binding
609:
607:
604:
603:
601:
598:
597:
594:
593:Gene ontology
590:
586:
574:
569:
565:
558:
553:
550:
548:
544:
536:
531:
520:
516:
512:
508:
504:
500:
496:
492:
488:
485:soleus muscle
484:
483:
480:
476:
471:
468:
458:
454:
450:
446:
442:
438:
434:
430:
426:
422:
421:
418:
414:
409:
406:
405:
402:
400:
396:
394:
393:
389:
388:
385:
383:
379:
375:
371:
367:
359:
354:
350:
346:
341:
335:18|18 A1
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1841:expanding it
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1734:
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1597:
1551:(2): 661–6.
1548:
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1443:
1439:
1386:(2): 661–6.
1383:
1379:
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1336:
1333:Cytoskeleton
1332:
1326:
1274:
1270:
1260:
1251:
1242:
1233:
1224:
1161:
1158:Interactions
1152:
1139:
1131:
1130:
1056:NP_001392219
1052:NP_001392211
1048:NP_001392210
1045:
1038:NP_001392209
1034:NP_001392207
1030:NP_001392206
1022:NP_001334378
999:NP_001310529
995:NP_001310528
992:
969:NM_001347449
958:
940:NM_001323600
936:NM_001323599
925:
901:
882:
856:
837:
811:
792:
772:
767:
677:cytoskeleton
397:
390:
117:External IDs
72:
1132:Supervillin
521:granulocyte
255:29,736,959
242:29,457,338
95:Identifiers
1880:Categories
1621:2022/26449
1219:, May 2017
1198:, May 2017
1174:References
401:(ortholog)
356:5,119,299
343:4,920,540
138:HomoloGene
1831:on human
1361:205643538
1026:NP_694793
1007:NP_068506
1003:NP_003165
965:NM_178046
961:NM_153153
932:NM_021738
928:NM_003174
758:Orthologs
672:costamere
632:cytoplasm
146:GeneCards
1796:17081983
1753:15324660
1718:15302935
1665:12917436
1630:12711699
1585:11792840
1532:11707406
1489:10362542
1440:Genomics
1420:11792840
1353:24155256
1215:–
1194:–
1164:interact
1149:Function
1104:Wikidata
737:Sources:
682:membrane
642:podosome
234:10p11.23
1804:7827573
1761:2371325
1686:Bibcode
1553:Bibcode
1460:9867483
1388:Bibcode
1301:9382871
1292:2140202
1217:Ensembl
1196:Ensembl
1136:protein
870:UniProt
825:Ensembl
764:Species
743:QuickGO
702:cytosol
687:nucleus
662:midbody
376:pattern
134:2147319
102:Aliases
1802:
1794:
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1716:
1709:514446
1706:
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1576:117362
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1523:125721
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1418:
1411:117362
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1299:
1289:
1090:search
1088:PubMed
903:Q8K4L3
884:O95425
813:225115
780:Entrez
547:BioGPS
517:atrium
423:glutes
126:604126
1835:is a
1800:S2CID
1757:S2CID
1357:S2CID
1166:with
1134:is a
773:Mouse
768:Human
739:Amigo
501:ankle
399:Mouse
392:Human
339:Start
274:Mouse
238:Start
171:Human
142:25090
1837:stub
1829:gene
1792:PMID
1774:Cell
1749:PMID
1714:PMID
1661:PMID
1626:PMID
1581:PMID
1528:PMID
1485:PMID
1456:PMID
1416:PMID
1349:PMID
1297:PMID
1143:gene
1140:SVIL
794:6840
382:Bgee
330:Band
291:Chr.
229:Band
188:Chr.
150:SVIL
122:OMIM
109:SVIL
79:2K6N
75:2K6M
56:RCSB
53:PDBe
22:SVIL
1782:doi
1778:127
1739:doi
1704:PMC
1694:doi
1682:101
1651:doi
1647:278
1616:hdl
1606:doi
1602:116
1571:PMC
1561:doi
1518:PMC
1510:doi
1477:doi
1448:doi
1406:PMC
1396:doi
1341:doi
1287:PMC
1279:doi
1275:139
352:End
251:End
154:OMA
130:MGI
46:PDB
1882::
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358:bp
345:bp
257:bp
244:bp
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