297:
274:
171:
196:
303:
202:
1739:
1582:
Jiao S, Hsu L, Berndt S, Bézieau S, Brenner H, Buchanan D, Caan BJ, Campbell PT, Carlson CS, Casey G, Chan AT, Chang-Claude J, Chanock S, Conti DV, Curtis KR, Duggan D, Gallinger S, Gruber SB, Harrison TA, Hayes RB, Henderson BE, Hoffmeister M, Hopper JL, Hudson TJ, Hutter CM, Jackson RD, Jenkins MA,
1329:
Luciano M, Lopez LM, de Moor MH, Harris SE, Davies G, Nutile T, Krueger RF, Esko T, Schlessinger D, Toshiko T, Derringer JL, Realo A, Hansell NK, Pergadia ML, Pesonen AK, Sanna S, Terracciano A, Madden PA, Penninx B, Spinhoven P, Hartman CA, Oostra BA, Janssens AC, Eriksson JG, Starr JM, Cannas A,
50:
1583:
Kantor ED, Kolonel LN, Küry S, Le
Marchand L, Lemire M, Newcomb PA, Potter JD, Qu C, Rosse SA, Schoen RE, Schumacher FR, Seminara D, Slattery ML, Ulrich CM, Zanke BW, Peters U (2012).
1373:
Verweij KJ, Vinkhuyzen AA, Benyamin B, Lynskey MT, Quaye L, Agrawal A, Gordon SD, Montgomery GW, Madden PA, Heath AC, Spector TD, Martin NG, Medland SE (September 2013).
310:
209:
1418:"Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1"
1719:
1196:
132:
857:
838:
1330:
Ferrucci L, Metspalu A, Wright MJ, Heath AC, van Duijn CM, Bierut LJ, Raikkonen K, Martin NG, Ciullo M, Rujescu D, Boomsma DI, Deary IJ (March 2012).
1818:
1636:
Warnatz HJ, Schmidt D, Manke T, Piccini I, Sultan M, Borodina T, Balzereit D, Wruck W, Soldatov A, Vingron M, Lehrach H, Yaspo ML (July 2011).
1375:"The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation"
1784:
1292:
1274:
1803:
1451:
Spaenij-Dekking EH, Van Delft J, Van Der
Meijden E, Hiemstra HS, Falkenburg JH, Koning F, Drijfhout JW, Kluin-Nelemans JC (December 2003).
1192:
296:
47:
1113:
273:
1120:
1638:"The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle"
1261:
1240:
1257:
195:
170:
1236:
112:
309:
208:
302:
201:
1777:
902:
120:
1813:
1529:
Wong KA, Wilson J, Russo A, Wang L, Okur MN, Wang X, Martin NP, Scappini E, Carnegie GK, O'Bryan JP (2012).
883:
1770:
1596:
1542:
184:
99:
1531:"Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks"
1212:
1096:
1092:
1078:
1074:
1070:
1066:
1047:
1021:
1017:
1003:
999:
995:
991:
972:
144:
1082:
1051:
1007:
976:
1704:
1669:
1624:
1570:
1517:
1474:
1453:"Synaptojanin 2 is recognized by HLA class II-restricted hairy cell leukemia-specific T cells"
1439:
1404:
1361:
92:
40:
1754:
1486:
Chuang Y, Xu X, Kwiatkowska A, Tsapraillis G, Hwang H, Petritis K, Flynn D, Symons M (2012).
1694:
1659:
1649:
1614:
1604:
1560:
1550:
1507:
1499:
1464:
1429:
1394:
1386:
1351:
1343:
389:
320:
264:
219:
140:
1200:
364:
1600:
1546:
1332:"Longevity candidate genes and their association with personality traits in the elderly"
1808:
1664:
1637:
1619:
1584:
1565:
1530:
1512:
1487:
1399:
1374:
1356:
1331:
772:
767:
762:
757:
752:
747:
731:
726:
721:
716:
711:
706:
701:
696:
691:
686:
681:
676:
671:
666:
650:
645:
640:
635:
630:
625:
620:
615:
610:
605:
600:
595:
590:
585:
580:
1797:
1723:
1390:
567:
124:
1750:
382:
161:
1699:
1682:
1609:
1555:
148:
1297:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1279:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1208:
465:
281:
178:
128:
1654:
802:
525:
403:
348:
335:
247:
234:
136:
1708:
1681:
Chuang YY, Tran NL, Rusk N, Nakada M, Berens ME, Symons M (November 2004).
1673:
1628:
1574:
1521:
1478:
1469:
1452:
1443:
1434:
1417:
1408:
1365:
1416:
Modregger J, Schmidt AA, Ritter B, Huttner WB, Plomann M (February 2003).
1160:
1155:
1347:
1310:
1204:
1144:
947:
928:
1336:
American
Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
1176:
914:
869:
1503:
69:
1128:
824:
1738:
1585:"Genome-wide search for gene-gene interactions in colorectal cancer"
787:
783:
1746:
1180:
116:
1683:"Role of synaptojanin 2 in glioma cell migration and invasion"
1488:"Regulation of synaptojanin 2 5'-phosphatase activity by Src"
626:
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
616:
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
606:
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
1199:, which causes translocation of the encoded protein to the
372:
1758:
758:
phosphatidylinositol-3-phosphate biosynthetic process
651:
phosphatidylinositol-4-phosphate phosphatase activity
631:
phosphatidylinositol phosphate 5-phosphatase activity
611:
phosphatidylinositol phosphate 4-phosphatase activity
537:
1065:
1040:
990:
965:
712:
extrinsic component of mitochondrial outer membrane
488:
dentate gyrus of hippocampal formation granule cell
1253:
1251:
1249:
1232:
1230:
1228:
319:
218:
1195:family. The encoded protein interacts with the
16:Protein-coding gene in the species Homo sapiens
1258:GRCm38: Ensembl release 89: ENSMUSG00000023805
1778:
636:inositol-polyphosphate 5-phosphatase activity
8:
1237:GRCh38: Ensembl release 89: ENSG00000078269
1211:. Alternative splicing results in multiple
621:phosphatidylinositol-3-phosphatase activity
1785:
1771:
1720:United States National Library of Medicine
1197:ras-related C3 botulinum toxin substrate 1
1062:
987:
798:
563:
360:
259:
156:
58:
1698:
1663:
1653:
1618:
1608:
1564:
1554:
1511:
1468:
1433:
1398:
1355:
748:phosphatidylinositol biosynthetic process
1718:This article incorporates text from the
1224:
1179:that in humans is encoded by the SYNJ2
753:phosphatidylinositol dephosphorylation
18:
324:
285:
280:
223:
182:
177:
7:
1735:
1733:
1193:inositol-polyphosphate 5-phosphatase
773:inositol phosphate dephosphorylation
1642:The Journal of Biological Chemistry
1422:The Journal of Biological Chemistry
581:phosphoric ester hydrolase activity
1757:. You can help Knowledge (XXG) by
1037:
962:
938:
919:
893:
874:
848:
829:
542:
460:
398:
377:
14:
1737:
1391:10.1111/j.1369-1600.2012.00478.x
504:lumbar subsegment of spinal cord
414:inferior ganglion of vagus nerve
308:
301:
295:
272:
207:
200:
194:
169:
727:perinuclear region of cytoplasm
526:More reference expression data
1:
1819:Human chromosome 6 gene stubs
1700:10.1158/0008-5472.CAN-04-2097
1492:Cell Adhesion & Migration
1311:"Entrez Gene: Synaptojanin 2"
293:
192:
1610:10.1371/journal.pone.0052535
1556:10.1371/journal.pone.0036023
1191:The gene is a member of the
1804:Genes on human chromosome 6
438:superior vestibular nucleus
1835:
1732:
1293:"Mouse PubMed Reference:"
1275:"Human PubMed Reference:"
1159:
1154:
1150:
1143:
1127:
1108:
1089:
1044:
1033:
1014:
969:
958:
945:
941:
926:
922:
913:
900:
896:
881:
877:
868:
855:
851:
836:
832:
823:
808:
801:
797:
781:
566:
562:
550:
545:
536:
523:
472:
463:
410:
401:
371:
363:
359:
342:
329:
292:
271:
262:
258:
241:
228:
191:
168:
159:
155:
110:
107:
97:
90:
85:
66:
61:
44:
39:
34:
30:
26:
21:
1114:Chr 6: 157.98 – 158.1 Mb
446:inferior olivary nucleus
418:internal globus pallidus
103:, INPP5H, synaptojanin 2
1655:10.1074/jbc.M111.220178
707:cytoplasmic microtubule
1470:10.1038/sj.leu.2403174
1435:10.1074/jbc.M208568200
1121:Chr 17: 5.99 – 6.09 Mb
508:superior frontal gyrus
450:ventral tegmental area
763:membrane organization
484:primary visual cortex
326:17 A1|17 3.59 cM
287:Chromosome 17 (mouse)
1348:10.1002/ajmg.b.32013
601:nucleic acid binding
185:Chromosome 6 (human)
62:List of PDB id codes
35:Available structures
1601:2012PLoSO...752535J
1547:2012PLoSO...736023W
1213:transcript variants
426:subthalamic nucleus
1745:This article on a
1722:, which is in the
1203:where it inhibits
903:ENSMUSG00000023805
741:Biological process
660:Cellular component
646:PDZ domain binding
641:SH3 domain binding
591:hydrolase activity
574:Molecular function
1766:
1765:
1504:10.4161/cam.22139
1379:Addiction Biology
1170:
1169:
1166:
1165:
1139:
1138:
1104:
1103:
1059:
1058:
1029:
1028:
984:
983:
954:
953:
935:
934:
909:
908:
890:
889:
864:
863:
845:
844:
793:
792:
768:brain development
558:
557:
554:
553:
532:
531:
519:
518:
457:
456:
430:medulla oblongata
355:
354:
254:
253:
149:SYNJ2 - orthologs
81:
80:
77:
76:
45:Ortholog search:
1826:
1787:
1780:
1773:
1741:
1734:
1712:
1702:
1677:
1667:
1657:
1648:(26): 23521–32.
1632:
1622:
1612:
1578:
1568:
1558:
1525:
1515:
1482:
1472:
1447:
1437:
1412:
1402:
1369:
1359:
1315:
1314:
1307:
1301:
1300:
1289:
1283:
1282:
1271:
1265:
1255:
1244:
1234:
1152:
1151:
1123:
1116:
1099:
1063:
1054:
1038:
1034:RefSeq (protein)
1024:
988:
979:
963:
939:
920:
894:
875:
849:
830:
799:
564:
543:
528:
468:
466:Top expressed in
461:
406:
404:Top expressed in
399:
378:
361:
351:
338:
327:
312:
305:
299:
288:
276:
260:
250:
237:
226:
211:
204:
198:
187:
173:
157:
151:
102:
95:
72:
59:
53:
32:
31:
19:
1834:
1833:
1829:
1828:
1827:
1825:
1824:
1823:
1794:
1793:
1792:
1791:
1730:
1715:
1687:Cancer Research
1680:
1635:
1581:
1528:
1485:
1463:(12): 2467–73.
1450:
1415:
1372:
1328:
1324:
1322:Further reading
1319:
1318:
1309:
1308:
1304:
1291:
1290:
1286:
1273:
1272:
1268:
1256:
1247:
1235:
1226:
1221:
1201:plasma membrane
1189:
1161:View/Edit Mouse
1156:View/Edit Human
1119:
1112:
1109:Location (UCSC)
1095:
1091:
1085:
1081:
1077:
1073:
1069:
1050:
1046:
1020:
1016:
1010:
1006:
1002:
998:
994:
975:
971:
884:ENSG00000078269
777:
736:
717:ruffle membrane
692:cell projection
687:plasma membrane
655:
586:protein binding
524:
515:
512:temporal muscle
510:
506:
502:
500:right ventricle
498:
494:
492:ascending aorta
490:
486:
482:
478:
476:muscle of thigh
464:
453:
448:
444:
442:corpus callosum
440:
436:
432:
428:
424:
420:
416:
402:
346:
333:
325:
315:
314:
313:
306:
286:
263:Gene location (
245:
232:
224:
214:
213:
212:
205:
183:
160:Gene location (
111:
98:
91:
68:
46:
17:
12:
11:
5:
1832:
1830:
1822:
1821:
1816:
1814:Human proteins
1811:
1806:
1796:
1795:
1790:
1789:
1782:
1775:
1767:
1764:
1763:
1742:
1714:
1713:
1693:(22): 8271–5.
1678:
1633:
1595:(12): e52535.
1579:
1526:
1483:
1448:
1413:
1370:
1342:(2): 192–200.
1325:
1323:
1320:
1317:
1316:
1302:
1284:
1266:
1245:
1223:
1222:
1220:
1217:
1188:
1185:
1173:Synaptojanin 2
1168:
1167:
1164:
1163:
1158:
1148:
1147:
1141:
1140:
1137:
1136:
1134:
1132:
1125:
1124:
1117:
1110:
1106:
1105:
1102:
1101:
1087:
1086:
1060:
1057:
1056:
1042:
1041:
1035:
1031:
1030:
1027:
1026:
1012:
1011:
985:
982:
981:
967:
966:
960:
956:
955:
952:
951:
943:
942:
936:
933:
932:
924:
923:
917:
911:
910:
907:
906:
898:
897:
891:
888:
887:
879:
878:
872:
866:
865:
862:
861:
853:
852:
846:
843:
842:
834:
833:
827:
821:
820:
815:
810:
806:
805:
795:
794:
791:
790:
779:
778:
776:
775:
770:
765:
760:
755:
750:
744:
742:
738:
737:
735:
734:
729:
724:
719:
714:
709:
704:
699:
694:
689:
684:
679:
674:
669:
663:
661:
657:
656:
654:
653:
648:
643:
638:
633:
628:
623:
618:
613:
608:
603:
598:
593:
588:
583:
577:
575:
571:
570:
560:
559:
556:
555:
552:
551:
548:
547:
540:
534:
533:
530:
529:
521:
520:
517:
516:
514:
513:
509:
505:
501:
497:
493:
489:
485:
481:
477:
473:
470:
469:
458:
455:
454:
452:
451:
447:
443:
439:
435:
431:
427:
423:
419:
415:
411:
408:
407:
395:
394:
386:
375:
369:
368:
365:RNA expression
357:
356:
353:
352:
344:
340:
339:
331:
328:
323:
317:
316:
307:
300:
294:
290:
289:
284:
278:
277:
269:
268:
256:
255:
252:
251:
243:
239:
238:
230:
227:
222:
216:
215:
206:
199:
193:
189:
188:
181:
175:
174:
166:
165:
153:
152:
109:
105:
104:
96:
88:
87:
83:
82:
79:
78:
75:
74:
64:
63:
55:
54:
43:
37:
36:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
1831:
1820:
1817:
1815:
1812:
1810:
1807:
1805:
1802:
1801:
1799:
1788:
1783:
1781:
1776:
1774:
1769:
1768:
1762:
1760:
1756:
1752:
1748:
1743:
1740:
1736:
1731:
1728:
1727:
1725:
1724:public domain
1721:
1710:
1706:
1701:
1696:
1692:
1688:
1684:
1679:
1675:
1671:
1666:
1661:
1656:
1651:
1647:
1643:
1639:
1634:
1630:
1626:
1621:
1616:
1611:
1606:
1602:
1598:
1594:
1590:
1586:
1580:
1576:
1572:
1567:
1562:
1557:
1552:
1548:
1544:
1541:(4): e36023.
1540:
1536:
1532:
1527:
1523:
1519:
1514:
1509:
1505:
1501:
1498:(6): 518–25.
1497:
1493:
1489:
1484:
1480:
1476:
1471:
1466:
1462:
1458:
1454:
1449:
1445:
1441:
1436:
1431:
1428:(6): 4160–7.
1427:
1423:
1419:
1414:
1410:
1406:
1401:
1396:
1392:
1388:
1385:(5): 846–50.
1384:
1380:
1376:
1371:
1367:
1363:
1358:
1353:
1349:
1345:
1341:
1337:
1333:
1327:
1326:
1321:
1312:
1306:
1303:
1298:
1294:
1288:
1285:
1280:
1276:
1270:
1267:
1263:
1259:
1254:
1252:
1250:
1246:
1242:
1238:
1233:
1231:
1229:
1225:
1218:
1216:
1214:
1210:
1206:
1202:
1198:
1194:
1186:
1184:
1182:
1178:
1174:
1162:
1157:
1153:
1149:
1146:
1142:
1135:
1133:
1130:
1126:
1122:
1118:
1115:
1111:
1107:
1100:
1098:
1094:
1088:
1084:
1080:
1076:
1072:
1068:
1064:
1061:
1055:
1053:
1049:
1043:
1039:
1036:
1032:
1025:
1023:
1019:
1013:
1009:
1005:
1001:
997:
993:
989:
986:
980:
978:
974:
968:
964:
961:
959:RefSeq (mRNA)
957:
950:
949:
944:
940:
937:
931:
930:
925:
921:
918:
916:
912:
905:
904:
899:
895:
892:
886:
885:
880:
876:
873:
871:
867:
860:
859:
854:
850:
847:
841:
840:
835:
831:
828:
826:
822:
819:
816:
814:
811:
807:
804:
800:
796:
789:
785:
780:
774:
771:
769:
766:
764:
761:
759:
756:
754:
751:
749:
746:
745:
743:
740:
739:
733:
730:
728:
725:
723:
722:axon terminus
720:
718:
715:
713:
710:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
672:membrane raft
670:
668:
665:
664:
662:
659:
658:
652:
649:
647:
644:
642:
639:
637:
634:
632:
629:
627:
624:
622:
619:
617:
614:
612:
609:
607:
604:
602:
599:
597:
594:
592:
589:
587:
584:
582:
579:
578:
576:
573:
572:
569:
568:Gene ontology
565:
561:
549:
544:
541:
539:
535:
527:
522:
511:
507:
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496:soleus muscle
495:
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25:
20:
1759:expanding it
1751:chromosome 6
1744:
1729:
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1287:
1278:
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1190:
1172:
1171:
1097:NP_001344596
1093:NP_001344594
1090:
1079:NP_001277627
1075:NP_001106824
1071:NP_001106823
1067:NP_001106822
1048:NP_001171559
1045:
1022:NM_001357667
1018:NM_001357665
1015:
1004:NM_001290698
1000:NM_001113353
996:NM_001113352
992:NM_001113351
973:NM_001178088
970:
946:
927:
901:
882:
856:
837:
817:
812:
697:cytoskeleton
388:
381:
246:158,099,176
233:157,981,863
108:External IDs
67:
1209:endocytosis
596:RNA binding
86:Identifiers
1798:Categories
1264:, May 2017
1243:, May 2017
1219:References
1207:-mediated
732:presynapse
422:C1 segment
392:(ortholog)
347:6,094,565
334:5,991,555
129:HomoloGene
1749:on human
1083:NP_035653
1052:NP_003889
1008:NM_011523
977:NM_003898
803:Orthologs
667:cytoplasm
480:spermatid
137:GeneCards
1709:15548694
1674:21555518
1629:23300701
1589:PLOS ONE
1575:22558309
1535:PLOS ONE
1522:23076136
1479:14562116
1457:Leukemia
1444:12456676
1409:22823124
1366:22213687
1260:–
1239:–
1205:clathrin
1187:Function
1145:Wikidata
782:Sources:
702:membrane
1665:3123115
1620:3530500
1597:Bibcode
1566:3338775
1543:Bibcode
1513:3547897
1400:3548058
1357:3583011
1262:Ensembl
1241:Ensembl
1177:protein
915:UniProt
870:Ensembl
809:Species
788:QuickGO
682:cytosol
367:pattern
125:1201671
93:Aliases
1707:
1672:
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1627:
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1573:
1563:
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1397:
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1354:
1131:search
1129:PubMed
948:Q9D2G5
929:O15056
825:Entrez
538:BioGPS
225:6q25.3
133:117703
117:609410
1809:Genes
1753:is a
1175:is a
858:20975
818:Mouse
813:Human
784:Amigo
390:Mouse
383:Human
330:Start
265:Mouse
229:Start
162:Human
141:SYNJ2
100:SYNJ2
22:SYNJ2
1755:stub
1747:gene
1705:PMID
1670:PMID
1625:PMID
1571:PMID
1518:PMID
1475:PMID
1440:PMID
1405:PMID
1362:PMID
1340:159B
1215:. .
1181:gene
839:8871
677:axon
434:pons
373:Bgee
321:Band
282:Chr.
220:Band
179:Chr.
113:OMIM
70:1UFW
51:RCSB
48:PDBe
1695:doi
1660:PMC
1650:doi
1646:286
1615:PMC
1605:doi
1561:PMC
1551:doi
1508:PMC
1500:doi
1465:doi
1430:doi
1426:278
1395:PMC
1387:doi
1352:PMC
1344:doi
546:n/a
343:End
242:End
145:OMA
121:MGI
41:PDB
1800::
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1691:64
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1248:^
1227:^
1183:.
786:/
349:bp
336:bp
248:bp
235:bp
143:;
139::
135:;
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1786:e
1779:t
1772:v
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267:)
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147::
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