609:
leptin. From there, she went on to discover the first single gene defect that causes obesity. For most us, how much we eat is within our control. But for children with this rare inherited condition and, it turned out, several other rare genetic disorders, the evidence is clear. A voracious appetite is not a lifestyle choice: it's a biological response to brains signalling starvation. Sadaf tells Jim how she discovered ten rare genetic disorders that cause severe childhood obesity and what this means for the rest of us.
1018:
44:
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Sadaf
Farooqi has fundamentally altered our understanding of human obesity. Her work was key to the discovery of the first mutations that cause human obesity, defining and characterising a range of previously undescribed genetic obesity syndromes, and establishing that the principal driver of obesity
608:
Is it true that some people put on weight more easily than others? And if so why? It's a question that's close to many of our hearts. And it's a question that medical researcher, Professor Sadaf
Farooqi is trying to answer. In 1997, Sadaf noticed that two children she was studying lacked the hormone
729:
OʼRahilly, Stephen; Montague, Carl T.; Farooqi, I. Sadaf; Whitehead, Jonathan P.; Soos, Maria A.; Rau, Harald; Wareham, Nicholas J.; Sewter, Ciaran P.; Digby, Janet E.; Mohammed, Shehla N.; Hurst, Jane A.; Cheetham, Christopher H.; Earley, Alison R.; Barnett, Anthony H.; Prins, Johannes B. (1997).
1031:
Pearce, Laura R.; Atanassova, Neli; Banton, Matthew C.; Bottomley, Bill; van der Klaauw, Agatha A.; Revelli, Jean-Pierre; Hendricks, Audrey; Keogh, Julia M.; Henning, Elana; Doree, Deon; Jeter-Jones, Sabrina; Garg, Sumedha; Bochukova, Elena G.; Bounds, Rebecca; Ashford, Sofie; Gayton, Emma;
1256:
964:
van der Klaauw, Agatha A.; Keogh, Julia M.; Henning, Elana; Stephenson, Cheryl; Kelway, Sarah; Trowse, Victoria M.; Subramanian, Naresh; O'Rahilly, Stephen; Fletcher, Paul C.; Farooqi, I. Sadaf (2016).
390:
1032:
Hindmarsh, Peter C.; Shield, Julian P.H.; Crowne, Elizabeth; Barford, David; Wareham, Nick J.; O'Rahilly, Stephen; Murphy, Michael P.; Powell, David R.; Barroso, Ines; Farooqi, I. Sadaf (2013).
946:
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Farooqi, I. Sadaf; Jebb, Susan A.; Langmack, Gill; Lawrence, Elizabeth; Cheetham, Christopher H.; Prentice, Andrew M.; Hughes, Ieuan A.; McCamish, Mark A.; O'Rahilly, Stephen (1999).
789:
Speliotes, Elizabeth K; Willer, Cristen J; Berndt, Sonja I; Monda, Keri L; Thorleifsson, Gudmar; Jackson, Anne U; Allen, Hana Lango; Lindgren, Cecilia M; Luan, Jian'an; Mägi (2010).
505:
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Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.;
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threats facing the international community and
Farooqi's research has been critical in bringing real biological insights where these were previously lacking.
1192:
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29:
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433:. She has been greatly committed to the translation of her research into patient benefit and has helped to change clinical attitudes and
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Wardle, Jane; Carnell, Susan; Haworth, Claire M. A.; Farooqi, I. Sadaf; O'Rahilly, Stephen; Plomin, Robert (2008).
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76:
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650:; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.;
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1154:
1034:"KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation"
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Professor Sadaf
Farooqi at the American Diabetes Association's 79th Scientific Session, June 2019
791:"Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index"
578:
553:
1108:
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1006:
967:"Divergent effects of central melanocortin signalling on fat and sucrose preference in humans"
908:
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331:
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672:"The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase"
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732:"Congenital leptin deficiency is associated with severe early-onset obesity in humans"
1235:
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438:
1211:"2019 Outstanding Scientific Achievement Award - Sadaf Farooqi, MB, ChB (Hons), PhD"
1120:
842:"Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency"
1085:"Obesity Associated Genetic Variation in FTO is Associated with Diminished Satiety"
343:
947:"Chicken korma, Eton mess and a genetic variant provide clues to our food choices"
860:
841:
456:
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120:
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350:. Research in her laboratory has shown that people who carry variants of the
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have an increased preference for high fat food (such as certain recipes of
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506:"Senior Research Fellowships in Clinical Science: people we've funded"
557:
339:
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161:
808:
1155:"Royal Society elects outstanding new Fellows and Foreign Members"
758:
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282:, she moved into research and was awarded a PhD in 2001 from the
366:
319:
391:
Framework
Programmes for Research and Technological Development
1257:
Fellows of the
Academy of Medical Sciences (United Kingdom)
338:(MC4R). Her group have also demonstrated that the central
1135:
Sadaf
Farooqi discusses how our genes affect our weight
1090:
The
Journal of Clinical Endocrinology and Metabolism
949:. Cambridge: University of Cambridge. Archived from
577:. Cambridge: University of Cambridge. Archived from
358:), but a decreased preference for sugary foods like
416:(FMedSci) in 2013. Her citation on election reads:
365:Her research has also proven that mutations in the
314:, her research group have identified patients with
182:
160:
129:
103:
86:
63:
53:
23:
466:Outstanding Scientific Achievement Award in 2019.
425:syndromes was a failure of the central control of
575:"Professor Sadaf Farooqi: Cambridge Neuroscience"
346:axis plays a critical role in the regulation of
606:
481:
479:
418:
883:Farooqi, I. Sadaf; O'Rahilly, Stephen (2006).
270:where she studied medicine, and was awarded a
375:fat mass and obesity-associated protein (FTO)
8:
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42:
20:
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1059:
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414:Fellow of the Academy of Medical Sciences
272:Bachelor of Medicine, Bachelor of Surgery
1262:Academics of the University of Cambridge
437:world-wide. Obesity is one of the major
928:"Slow metabolism 'obesity excuse' true"
627:(PhD thesis). University of Cambridge.
533:
531:
529:
527:
475:
381:. Her research has been funded by the
1252:Alumni of the University of Cambridge
592:
590:
588:
7:
1272:21st-century British medical doctors
1267:20th-century British medical doctors
624:Genetics of severe childhood obesity
602:"Sadaf Farooqi on what makes us fat"
302:Farooqi's research investigates the
168:Genetics of severe childhood obesity
274:degree in 1993. After working as a
373:and that genetic variation in the
14:
1185:"Professor Sadaf Farooqi FMedSci"
1016:
885:"Genetics of Obesity in Humans"
847:New England Journal of Medicine
464:American Diabetes Association's
387:Addenbrooke's Charitable Trust
334:of leptin action, such as the
310:found in patients with severe
276:pre-registration house officer
1:
1277:British women medical doctors
930:. London: BBC. Archived from
621:Farooqi, Ismaa Sadaf (2001).
1287:Fellows of the Royal Society
554:Sadaf Farooqi's publications
266:Farooqi was educated at the
16:British consultant physician
1193:Academy of Medical Sciences
861:10.1056/NEJM199909163411204
445:Farooqi was interviewed by
407:Fellow of the Royal Society
1303:
1052:10.1016/j.cell.2013.09.058
1215:professional.diabetes.org
369:gene are associated with
178:
96:
41:
1282:British women scientists
945:Brierley, Craig (2016).
926:Gallager, James (2013).
560:bibliographic database.
488:publications indexed by
462:Farooqi was awarded the
268:University of Birmingham
202:/principal-investigators
71:University of Birmingham
698:10.1126/science.1151710
562:(subscription required)
336:Melanocortin 4 receptor
284:University of Cambridge
244:University of Cambridge
147:University of Cambridge
142:John Radcliffe Hospital
77:University of Cambridge
611:
443:
412:Farooqi was elected a
405:Farooqi was elected a
252:Addenbrooke's Hospital
152:Addenbrooke's Hospital
972:Nature Communications
455:, first broadcast on
1104:10.1210/jc.2008-0472
904:10.1210/er.2006-0040
286:for research on the
280:senior house officer
248:consultant physician
242:and Medicine at the
137:University of Oxford
1143:Wellcome Collection
993:10.1038/ncomms13055
985:2016NatCo...713055V
953:on 8 November 2016.
934:on 6 February 2016.
750:1997Natur.387..903M
690:2007Sci...318.1469G
684:(5855): 1469–1472.
543:0000-0001-7609-3504
520:on 25 January 2017.
452:The Life Scientific
435:diagnostic practice
377:is associated with
304:genetics of obesity
215:Ismaa Sadaf Farooqi
91:Genetics of obesity
58:Ismaa Sadaf Farooqi
401:Awards and honours
371:insulin resistance
332:biological targets
1199:on 1 August 2016.
1159:The Royal Society
890:Endocrine Reviews
744:(6636): 903–908.
379:diminished hunger
348:human food intake
292:childhood obesity
212:
211:
98:Scientific career
1294:
1226:
1225:
1223:
1221:
1207:
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1195:. Archived from
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1097:(9): 3640–3643.
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668:Schofield, C. J.
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618:
612:
605:
594:
583:
582:
581:on 18 June 2016.
570:
564:
563:
551:
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537:Sadaf Farooqi's
535:
522:
521:
516:. Archived from
501:
492:
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236:Clinical Science
225:
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204:/i-sadaf-farooqi
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854:(12): 879–884.
839:
838:
834:
803:(11): 937–948.
796:Nature Genetics
788:
787:
783:
728:
727:
723:
660:Ashcroft, F. M.
645:
644:
640:
620:
619:
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598:Al-Khalili, Jim
596:
595:
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572:
571:
567:
561:
556:indexed by the
552:
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495:
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477:
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403:
393:(FP7) from the
328:leptin receptor
308:candidate genes
300:
264:
238:, professor of
232:Research fellow
217:
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125:
82:
64:Alma mater
59:
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12:
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1247:Wellcome Trust
1244:
1234:
1233:
1228:
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1189:acmedsci.ac.uk
1172:
1146:
1126:
1075:
1046:(4): 765–777.
1023:
956:
937:
918:
897:(7): 710–718.
875:
832:
809:10.1038/ng.686
781:
721:
656:Ponting, C. P.
638:
613:
604:. London: BBC.
584:
565:
546:
523:
514:Wellcome Trust
510:wellcome.ac.uk
493:
490:Google Scholar
474:
473:
471:
468:
447:Jim Al-Khalili
402:
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395:European Union
383:Wellcome Trust
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1183:Anon (2013).
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573:Anon (2016).
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500:
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486:Sadaf Farooqi
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25:Sadaf Farooqi
22:
19:
1218:. Retrieved
1214:
1205:
1197:the original
1188:
1163:. Retrieved
1161:. 6 May 2021
1158:
1149:
1129:
1094:
1088:
1078:
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579:the original
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461:
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419:
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364:
344:melanocortin
301:
265:
214:
213:
166:
130:Institutions
97:
18:
1220:14 November
652:Lindahl, T.
648:Rorsman, P.
457:BBC Radio 4
1236:Categories
1191:. London:
512:. London:
470:References
290:of severe
240:Metabolism
121:Metabolism
979:: 13055.
776:205032762
633:894596925
459:in 2017.
423:monogenic
421:in these
409:in 2021.
360:Eton mess
352:MC4R gene
322:encoding
316:mutations
262:Education
256:Cambridge
200:/research
1121:13929741
1113:18583465
1070:24209692
1011:27701398
913:17122358
870:10486419
827:20935630
716:17991826
670:(2007).
600:(2017).
427:appetite
389:and the
306:. Using
298:Research
288:genetics
116:Genetics
1140:YouTube
1061:3898740
1002:5059464
981:Bibcode
818:3014648
768:9202122
746:Bibcode
707:2668859
686:Bibcode
677:Science
431:satiety
312:obesity
230:Senior
219:FMedSci
183:Website
111:Obesity
73:(MBChB)
30:FMedSci
1165:21 May
1119:
1111:
1068:
1058:
1009:
999:
911:
868:
825:
815:
774:
766:
737:Nature
714:
704:
631:
558:Scopus
541:
340:leptin
326:, the
324:leptin
258:, UK.
246:and a
173:(2001)
171:
162:Thesis
104:Fields
1117:S2CID
772:S2CID
539:ORCID
320:genes
226:is a
221:
79:(PhD)
32:
1222:2019
1167:2021
1109:PMID
1066:PMID
1039:Cell
1007:PMID
909:PMID
866:PMID
823:PMID
764:PMID
712:PMID
629:OCLC
429:and
367:KSR2
330:and
278:and
194:.cam
192:.ims
190:.mrl
54:Born
1138:on
1099:doi
1056:PMC
1048:doi
1044:155
997:PMC
989:doi
899:doi
856:doi
852:341
813:PMC
805:doi
754:doi
742:387
702:PMC
694:doi
682:318
449:on
318:in
254:in
250:at
234:in
223:FRS
198:.uk
196:.ac
188:www
34:FRS
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
