44:
295:(containing table salt and baking soda) to replace the lost salts (the "Peru Project"). His research group demonstrated that this therapy was an effective alternative to the traditional treatment using intravenous injections of whole blood or plasma. The simplified burn therapy remains widely used.
290:
In the early 1940s, Rosenthal worked on improving the ability of victims of severe burns to survive. Death commonly resulted from shock due to fluid (plasma) loss from the burned skin. He discovered that the replacement of the salts that are in the secreted plasma is the key to a successful and
237:
Rosenthal's first published paper provided a method for testing the health of the liver. He showed that the rate at which the liver metabolizes an ingested dye can be used to quantify how well this organ functions. His continued work on
213:
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biochemistry and physiology. They developed a widely used method for quantifying histamine, worked on the pharmacology of histamines, and determined the biosynthetic pathway for
270:
Based on his observation that sodium formaldehyde sulfoxylate also has antibacterial activity, Rosenthal began work on another group of sulfur-containing compounds -– the
351:
347:
340:
670:
668:
Bocanegra, M.; Hinostroza, F.; Kefalides, N.A.; Markley, K.; Rosenthal, S.M. (1966). "A long-term study of early fluid therapy in severely burned adults".
540:
496:
384:
923:
938:
523:
Plaa, G.L. (2010). "Evaluation of hepatotoxicity: physiological and biochemical measures of hepatic function in animals". In McQueen, C.A. (ed.).
192:(1921–1922). However, his interests shifted to medical research when he became a Fellow of the National Research Council in a pharmacology lab at
908:
324:
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336:
205:
291:
simplified treatment. During the 1950s and early 1960s, Rosenthal and colleagues undertook a long-term study to test the efficacy of
933:
606:
802:
567:
Rosenthal, S.M. (1934). "Studies in chemotherapy. I. The action of sodium formaldehyde sulphoxylate in bacterial infections".
628:
Rosenthal, S.M. (1943). "Experimental chemotherapy of burns and shock. III. Effects of systemic therapy on early mortality".
436:
259:
328:
167:
355:
292:
258:. This antidote was widely used, and Rosenthal's discovery is considered one of the major achievements in the
193:
128:
767:
Rosenthal, S.M.; Tabor, H. (1956). "The pharmacology of spermine and spermidine. Distribution and excretion".
699:"Oral and enteral resuscitation of burn shock. The historical record and implications for mass casualty care"
494:
Rosenthal, S.M.; White, E.C. (1925). "Clinical application of the bromsulphalein test for hepatic function".
473:
Rosenthal, S.M. (1922). "An improved method for using phenoltetrachlorphthlalein as a liver function test".
604:
Rosenthal, S.M. (1937). "The chemotherapy of certain infections with sulfanilamide and related compounds".
271:
839:
Ames, B.N.; Dubin, D.T.; Rosenthal, S.M. (1958). "Presence of polyamines in certain bacterial viruses".
630:
569:
185:
106:
697:
Kramer, G.C.; Michell, M.W.; Oliveira, H.; Brown, T.L.H.; Herndon, D.; Baker, R.D.; Muller, M. (2010).
738:
Rosenthal, S.M.; Tabor, H. (1948). "An improved colorimetric method for the estimation of histamine".
903:
898:
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239:
189:
116:
389:
275:
124:
43:
874:
647:
586:
413:
866:
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821:
778:
749:
720:
455:
255:
197:
120:
86:
858:
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243:
209:
201:
67:
20:
854:
715:
698:
816:
797:
216:
for 13 years before retiring in 1961. He attained the rank of medical director in the
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683:
553:
509:
450:
431:
279:
354:. In 1973, he received the Harvey Stuart Allen Distinguished Service Award from the
878:
862:
157:
224:
for almost 20 years. He was an author on over 110 papers between 1922 and 1975.
212:
Dr. Rosenthal was Chief of the
Laboratory of Pharmacology and Toxicology at the
362:
in recognition of his pioneering work on the treatment of shock due to burns.
308:
798:"The biosynthesis of spermidine and spermine from putrescine and methionine"
312:
304:
132:
870:
825:
782:
753:
724:
459:
358:. In 1980, he received the Award for Experimental Therapeutics from the
651:
590:
643:
582:
538:
Rosenthal, S.M. (1934). "An antidote for acute mercury poisoning".
221:
274:. His decade-long work on sulfa drugs led to his discovery of a
220:. After retiring, Dr. Rosenthal continued to do research at the
360:
American
Society for Pharmacology and Experimental Therapeutics
333:
American
Society for Pharmacology and Experimental Therapeutics
254:
Rosenthal discovered that sodium formaldehyde sulfoxylate was
214:
National
Institute of Arthritis and Metabolic Diseases (NIAMD)
303:
Rosenthal and his collaborators were pioneers in the area of
196:(1922–1925). He worked in the Department of Pharmacology at
311:. Rosenthal also collaborated in research on the role of
770:
741:
476:
188:
in 1920, and completed a residency and internship at
929:
Fellows of the
American Academy of Arts and Sciences
527:. Vol. 9. Elsevier, New York. pp. 129–140.
204:from 1925 to 1927. Finally, in 1928, he joined the
163:
153:
138:
112:
102:
94:
75:
53:
28:
142:Lillian Lieberfeld Rosenthal (m. 1930; 3 children)
414:"Rosenthal Retires After 33 Years Service at NIH"
352:U.S. Department of Health, Education, and Welfare
796:Tabor, H.; Rosenthal, S.M.; Tabor, C.W. (1958).
914:Vanderbilt University School of Medicine alumni
432:"Effect of age on transvascular fluid movement"
348:Public Health Service Meritorious Service Medal
341:Society for Experimental Biology and Medicine
8:
671:Journal of the American Medical Association
541:Journal of the American Medical Association
497:Journal of the American Medical Association
206:United States Public Health Service (USPHS)
607:Medical Annals of the District of Columbia
25:
815:
714:
663:
661:
449:
623:
621:
19:(May 5, 1897 – May 1, 1989) was born in
371:
430:Rosenthal, S.M.; LaJohn, L.A. (1975).
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377:
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260:history of medical research at the NIH
408:
406:
404:
402:
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325:American Academy of Arts and Sciences
7:
276:treatment for pneumococcal pneumonia
337:Society of American Bacteriologists
14:
327:in 1979. He was also a member of
256:an antidote for mercury poisoning
924:20th-century American scientists
684:10.1001/jama.1966.03100040074020
554:10.1001/jama.1934.02750160007002
510:10.1001/jama.1925.02660410020008
451:10.1152/ajplegacy.1975.228.1.134
218:USPHS Commissioned Officer Corps
184:He received a medical degree at
42:
803:Journal of Biological Chemistry
385:"DR. SANFORD M. ROSENTHAL DIES"
228:Major contributions to medicine
939:20th-century American chemists
863:10.1126/science.127.3302.814-a
437:American Journal of Physiology
315:in the function of viral DNA.
1:
817:10.1016/S0021-9258(18)64676-9
323:Rosenthal was elected to the
266:Antibiotic cure for pneumonia
125:Antibiotic cure for pneumonia
909:Vanderbilt University alumni
329:American Medical Association
168:National Institute of Health
919:People from Albany, Georgia
955:
293:drinking a saline solution
250:Mercury poisoning antidote
121:Mercury poisoning antidote
356:American Burn Association
346:In 1962, he received the
173:
146:
41:
934:American pharmacologists
525:Comprehensive Toxicology
246:, which remains in use.
194:Johns Hopkins University
17:Sanford Morris Rosenthal
242:resulted in the use of
631:Public Health Reports
570:Public Health Reports
186:Vanderbilt University
180:Early life and career
107:Vanderbilt University
240:liver function tests
233:Liver function tests
190:Boston City Hospital
117:Liver function tests
855:1958Sci...127..814A
390:The Washington Post
849:(3302): 814–816.
548:(16): 1273–1276.
504:(15): 1112–1114.
319:Awards and honors
198:McGill University
177:
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148:Scientific career
87:Potomac, Maryland
48:Sanford Rosenthal
33:Sanford Rosenthal
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244:bromsulphthalein
210:Washington, D.C.
202:Montreal, Canada
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638:(13): 513–522.
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583:10.2307/4581259
577:(31): 908–911.
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103:Alma mater
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68:Albany, Georgia
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21:Albany, Georgia
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810:(4): 907–914.
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113:Known for
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83:(aged 91)
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419:. p. 3.
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286:Burn therapy
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183:
164:Institutions
158:Pharmacology
147:
129:Burn therapy
81:(1989-05-01)
16:
15:
904:1989 deaths
899:1897 births
272:sulfa drugs
95:Nationality
79:May 1, 1989
64:May 5, 1897
893:Categories
614:: 337–343.
483:: 385–391.
366:References
313:polyamines
309:spermidine
299:Histamines
133:Histamines
60:1897-05-05
350:from the
305:histamine
871:13543336
826:13587513
783:13296028
754:18911841
725:20827301
98:American
879:9934860
851:Bibcode
842:Science
716:2933130
709:: e56.
703:ePlasty
652:4584415
591:4581259
460:1147003
877:
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824:
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752:
723:
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589:
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339:, and
154:Fields
139:Spouse
89:, U.S.
70:, U.S.
875:S2CID
648:JSTOR
587:JSTOR
417:(PDF)
278:with
222:NIAMD
867:PMID
822:PMID
779:PMID
750:PMID
721:PMID
456:PMID
76:Died
54:Born
859:doi
847:127
812:doi
808:233
775:116
711:PMC
680:doi
676:195
640:doi
579:doi
550:doi
546:102
506:doi
446:doi
442:228
208:in
200:in
895::
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399:^
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374:^
343:.
335:,
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36:MD
30:Dr
23:.
881:.
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612:6
593:.
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62:)
58:(
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