249:
583:"has a right of first negotiation". They currently have essentially all marketing rights globally for the compounds in association with their drug development programs. Numerous patents from Cyclacel are found related to sapacitibine and sapacitibine dosing regimes along with other drugs such as decitibine. There are patents and applications that no longer apply to current use of sapacitibine, some involving administration of sapacitibine and seliciclib.
534:) patients with good renal and liver function and who are not viable candidates for or have refused intensive induction chemotherapy. SEAMLESS is a global study with 118 different sites in the United States, Austria, Belgium, France, Germany, Hungary, Italy, Poland, Spain, Sweden, Switzerland, and the United Kingdom. In the trial an arm of oral sapacitibine is given in alternating cycles with IV
576:
2016 with 15.9 million dollars in cash and equivalents. An earnings report from H.C. Wainwright & Co. acknowledged how
Cyclacel may at first seem like an unattractive investment but the ultimate risk/reward opportunity may be positive; sapacitibine has indeed shown very positive anti-tumor activity and has progressed to Phase III clinical trials for elderly patients with AML.
29:
538:, which is compared to the control arm of IV decitabine alone. The SEAMLESS study was constructed based on the promising results of a Phase II one-year survival study for patients with AML. The efficacy goal of the treatment is overall survival; the average survival of an elderly person diagnosed with AML is approximately three to six months. The
543:
results from a Phase I/II clinical trial studying the safety and efficacy of the oral sapacitibine along with IV decitabine were presented, selected data highlights are as follows: median overall survival was approximately 8 months, patients still alive at 3 months was 83%, 35% of patients survived a year or longer, 2 dose-limiting
558:
For the Phase II trial for MDS patients so far, median survival overall was about 9.7 months, with the average median survival overall for patients receiving classic azacitidine or decitabine is approximately 4.3-5.9 months. More data will be arriving from the second half of this trial meant to allow
575:
As of August 2016, Cyclacel had a 19.5 million dollar market capitalization and shares of the company have declined in value recently due to research and development costs of 2.6 million dollars and general and administrative expense costs of 1.3 million dollars. Cyclacel ended the last quarter in
542:
has communicated the unlikelihood that this Phase III study will reach a statistically significant survival improvement due to the planned futility boundary of 247 patient deaths already being crossed, but the trial is ongoing. During a poster session at the 2012 American
Society of Hematology,
586:
Cyclacel currently has no sales or marketing capability and so will rely on alliances to distribute and commercialize the various drugs they hope to bring through the development pipeline. These compounds particularly target control of the cell cycle for treating cancer and other diseases.
602:
to sapacitibine for the treatment of AML and MDS; this designation assists in funding and provides various benefits for the drug's development such as market exclusivity for a period of several years, grant funding, tax credits, and potential fee waivers.
322:
562:
The Phase II study for sapacitibine with seliciclib in advanced cancer patients is ongoing; so far, "durable partial responses" and "prolonged stable disease" have been seen particularly for patients with the
364:
InChI=1S/C26H42N4O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-23(32)28-22-16-17-30(26(34)29-22)25-20(18-27)24(33)21(19-31)35-25/h16-17,20-21,24-25,31,33H,2-15,19H2,1H3,(H,28,29,32,34)/t20-,21+,24-,25+/m0/s1
54:
380:
858:
523:
for cancer treatment including hereditary ovarian and breast cancers. Thus far approximately 1,000 patients have received sapacitibine treatment in all phases of trials.
997:
430:) that acts through a dual mechanism. CNDAC lasts longer in the bloodstream by being metabolized from sapacitibine than it would do so by being directly administered.
1697:
336:
590:
Cyclacel says current funds and generated money from items such as R&D tax credits and "recent financing activities" will carry them through 2017. The
2717:
567:
mutations. In a group of 45 patients including those with breast, ovarian, and pancreatic cancers, a "35.6% disease control rate was observed."
2673:
990:
921:
Fein, Andrew S., Emile Yu, and Rachel F. Lane. H.C.Wainwright & Co. Cyclacel
Pharmaceuticals, Inc. 12 August 2016. Web. 5 November 2016.
620:
Faderl S, Gandhi V, Kantarjian HM (March 2008). "Potential role of novel nucleoside analogs in the treatment of acute myeloid leukemia".
2280:
437:
by causing single-strand DNA breaks due to CNDAC being incorporated into DNA during replication or repair, then inducing arrest of the
2722:
1432:
1388:
1266:
1191:
356:
983:
1913:
1707:
78:
956:"Cyclin Dependent Kinase (CDK) and Aurora Kinase (AK) inhibitors | Cyclacel R&D for anticancer drugs acting on cell cycle"
2326:
1328:
1218:
2248:
2231:
2106:
1870:
1248:
769:"Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks"
511:
Sapacitabine is being evaluated as of March 2016 in three different studies; a Phase III trial for elderly patients with
1980:
1576:
595:
168:
743:
2690:
2182:
975:
548:
527:
228:
1362:
2548:
2428:
2418:
591:
552:
539:
665:"Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells"
2600:
2533:
2503:
2121:
1371:
516:
493:
2678:
2585:
2403:
2118:
1604:
1452:
1379:
461:
2483:
2473:
2206:
2048:
531:
512:
501:
2742:
1755:
1572:
1542:
1402:
845:
for "A Study of Oral
Sapacitabine in Elderly Patients With Newly Diagnosed Acute Myeloid Leukemia" at
2737:
2732:
2153:
2030:
1551:
1467:
859:"Cyclacel: Innovative Medicines for Cancer and other proliferative diseases using cell cycle biology"
244:
2438:
2338:
2317:
2038:
1860:
1692:
1423:
1319:
477:
416:
103:
1496:
846:
645:
599:
2645:
1526:
1506:
1491:
217:
2727:
2620:
2194:
1028:
798:
694:
663:
Serova M, Galmarini CM, Ghoul A, Benhadji K, Green SR, Chiao J, et al. (September 2007).
637:
889:
2625:
2382:
2097:
1731:
1716:
1437:
788:
780:
684:
676:
629:
505:
265:
157:
112:
427:
177:
2064:
2026:
1817:
1239:
1154:
931:
248:
579:
Cyclacel holds worldwide right to commercialize sapacitibine, except in Japan for which
2684:
2218:
1809:
1303:
1167:
1054:
1024:
1011:
793:
768:
689:
664:
580:
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2558:
2518:
1888:
1761:
1642:
1585:
1343:
1292:
564:
497:
438:
434:
649:
530:, SEAMLESS, has 485 enrolled members and is open to elderly (70+ years of age) AML (
2605:
2569:
2453:
2443:
2397:
2393:
2355:
2263:
2053:
1992:
1988:
1969:
1964:
1943:
1932:
1746:
1740:
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1652:
1647:
1600:
1486:
1353:
1333:
1262:
1211:
1201:
1015:
1007:
401:
137:
841:
508:
of a variety of dosing schedules in approximately 120 patients with solid tumors.
633:
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2523:
2463:
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457:
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2007:
2002:
1948:
1893:
1845:
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1376:
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1074:
535:
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298:
148:
20:
2655:
2635:
2590:
2580:
2574:
2478:
2423:
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2241:
2228:
2169:
2131:
2059:
1997:
1938:
1927:
1883:
1840:
1799:
1793:
1789:
1751:
1678:
1673:
1663:
1635:
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1531:
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1127:
1117:
1112:
1107:
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802:
698:
680:
641:
784:
28:
2564:
2528:
2468:
2236:
2174:
1954:
1850:
1822:
1501:
1338:
955:
544:
442:
409:
405:
1457:
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1033:
419:
123:
1097:
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321:
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208:
816:
473:
188:
979:
500:
and combination studies with other anti-cancer agents. Three
233:
480:, in delaying the onset and growth of liver metastasis.
387:
468:
mouse model, sapacitabine was shown to be superior to
767:
Liu XJ, Nowak B, Wang YQ, Plunkett W (August 2012).
344:
CCCCCCCCCCCCCCCC(=O)NC1=NC(=O)N(C=C1)2(((O2)CO)O)C#N
2365:
2316:
2096:
2089:
2025:
1979:
1912:
1869:
1706:
1691:
1571:
1541:
1466:
1451:
1422:
1318:
1238:
1181:
1164:
1153:
1089:
1042:
1023:
310:
297:
264:
259:
227:
207:
187:
167:
147:
122:
102:
69:
53:
40:
35:
90:-arabinofuranosyl)-4-(palmitoylamino)pyrimidin-2(1
744:"Cyclacel Pharmaceuticals, Inc. - Annual Report"
504:have been completed, which evaluated safety and
136:
111:
991:
408:currently undergoing clinical trials against
8:
571:Commercial Aspects and Intellectual Property
19:
519:), and a Phase I trial in combination with
492:to evaluate sapacitabine in both solid and
2093:
1703:
1463:
1178:
1161:
1039:
998:
984:
976:
247:
156:
27:
792:
688:
176:
496:tumors laying the foundation for future
612:
361:
341:
243:
83:
18:
738:
736:
734:
732:
730:
728:
216:
7:
917:
915:
913:
884:
882:
880:
878:
726:
724:
722:
720:
718:
716:
714:
712:
710:
708:
415:Sapacitabine is an orally available
48:--2-oxopyrimidin-4-yl]hexadecanamide
1267:ribonucleotide reductase inhibitors
488:Cyclacel has initiated a number of
404:developed by US biotechnology firm
196:
127:
1433:Ribonucleotide reductase inhibitor
1389:Ribonucleotide reductase inhibitor
452:, CNDAC, have demonstrated potent
426:-arabino-pentofuranosyl-cytosine (
14:
1192:Dihydrofolate reductase inhibitor
448:Both sapacitabine and its major
282:
276:
592:European Medicines Agency (EMA)
369:Key:LBGFKUUHOPIEMA-PEARBKPGSA-N
2718:Drugs not assigned an ATC code
1329:Thymidylate synthase inhibitor
1219:Thymidylate synthase inhibitor
932:"sapacitabine - Google Search"
502:Phase I clinical trial studies
288:
270:
1:
1249:Adenosine deaminase inhibitor
1090:Block microtubule disassembly
622:Current Opinion in Hematology
433:The compound interferes with
634:10.1097/MOH.0b013e3282f46e94
596:Food and Drug Administration
540:Data Safety Monitoring Board
515:, a Phase II trial for MDS (
513:AML (acute myeloid leukemia)
456:activity in both blood and
422:of 2′-C-cyano-2′-deoxy-1-β-
2759:
260:Chemical and physical data
2723:Experimental cancer drugs
2668:
2549:Omacetaxine mepesuccinate
2429:Ciltacabtagene autoleucel
2419:Brexucabtagene autoleucel
773:Chinese Journal of Cancer
669:British Journal of Cancer
517:myelodysplastic syndromes
377:
352:
332:
74:
26:
2601:Talimogene laherparepvec
2534:Nadofaragene firadenovec
2504:Lisocabtagene maraleucel
1453:Topoisomerase inhibitors
1372:DNA polymerase inhibitor
559:better dosing regimens.
528:Phase III clinical trial
2404:Axicabtagene ciloleucel
1008:chemotherapeutic agents
2586:Sitimagene ceradenovec
2484:Idecabtagene vicleucel
2049:Methyl aminolevulinate
839:Clinical trial number
681:10.1038/sj.bjc.6603896
532:acute myeloid leukemia
2060:Porphyrin derivatives
1756:Melphalan flufenamide
1403:Hypomethylating agent
1012:antineoplastic agents
821:www.seamlessstudy.com
785:10.5732/cjc.012.10077
748:investor.cyclacel.com
402:chemotherapeutic drug
86:1-(2-cyano-2-deoxy-β-
2389:Asparagine depleters
2318:Receptor antagonists
2232:+abiraterone acetate
817:"The SEAMLESS Study"
2439:Denileukin diftitox
2339:Retinoid X receptor
2039:Aminolevulinic acid
1861:Triethylenemelamine
1693:Crosslinking of DNA
1424:Deoxyribonucleotide
1363:+gimeracil/oteracil
598:(FDA) have granted
462:preclinical studies
23:
2695:Never to phase III
1497:Etirinotecan pegol
847:ClinicalTrials.gov
600:orphan drug status
478:nucleoside analogs
476:, two widely used
2705:
2704:
2664:
2663:
2621:Tigilanol tiglate
2098:Enzyme inhibitors
2021:
2020:
2017:
2016:
1717:Nitrogen mustards
1687:
1686:
1447:
1446:
1149:
1148:
417:nucleoside analog
395:
394:
323:Interactive image
229:CompTox Dashboard
89:
49:
16:Chemical compound
2750:
2626:Tisagenlecleucel
2383:Arsenic trioxide
2094:
2027:Photosensitizers
1818:Alkyl sulfonates
1732:Cyclophosphamide
1704:
1643:Anthracenediones
1464:
1438:Hydroxycarbamide
1179:
1162:
1040:
1000:
993:
986:
977:
970:
969:
967:
966:
960:www.cyclacel.com
952:
946:
945:
943:
942:
928:
922:
919:
908:
907:
905:
904:
894:
886:
873:
872:
870:
869:
863:
855:
849:
837:
831:
830:
828:
827:
813:
807:
806:
796:
764:
758:
757:
755:
754:
740:
703:
702:
692:
660:
654:
653:
617:
506:pharmacokinetics
498:Phase II studies
391:
390:
383:
325:
305:
290:
284:
278:
272:
252:
251:
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220:
200:
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130:
129:
115:
87:
44:
31:
24:
22:
2758:
2757:
2753:
2752:
2751:
2749:
2748:
2747:
2708:
2707:
2706:
2701:
2700:
2685:Clinical trials
2660:
2366:Other/ungrouped
2361:
2312:
2085:
2065:Porfimer sodium
2013:
1975:
1908:
1865:
1695:
1683:
1567:
1537:
1455:
1443:
1418:
1314:
1234:
1170:
1168:antimetabolites
1166:
1165:DNA precursors/
1157:
1155:DNA replication
1145:
1085:
1055:Vinca alkaloids
1031:
1019:
1004:
974:
973:
964:
962:
954:
953:
949:
940:
938:
930:
929:
925:
920:
911:
902:
900:
892:
888:
887:
876:
867:
865:
861:
857:
856:
852:
838:
834:
825:
823:
815:
814:
810:
766:
765:
761:
752:
750:
742:
741:
706:
662:
661:
657:
619:
618:
614:
609:
573:
555:were observed.
547:in the form of
490:clinical trials
486:
484:Clinical trials
386:
384:
381:(what is this?)
378:
373:
370:
365:
360:
359:
348:
345:
340:
339:
328:
303:
293:
287:
281:
275:
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231:
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183:
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143:
126:
118:
98:
95:
82:
81:
65:
17:
12:
11:
5:
2756:
2754:
2746:
2745:
2740:
2735:
2730:
2725:
2720:
2710:
2709:
2703:
2702:
2699:
2698:
2697:
2696:
2693:
2682:
2676:
2670:
2669:
2666:
2665:
2662:
2661:
2659:
2658:
2653:
2648:
2643:
2638:
2633:
2628:
2623:
2618:
2613:
2608:
2603:
2598:
2593:
2588:
2583:
2578:
2572:
2561:
2556:
2551:
2546:
2541:
2536:
2531:
2526:
2521:
2516:
2511:
2506:
2501:
2496:
2491:
2486:
2481:
2476:
2471:
2466:
2461:
2456:
2451:
2446:
2441:
2436:
2431:
2426:
2421:
2416:
2411:
2406:
2401:
2385:
2380:
2375:
2369:
2367:
2363:
2362:
2360:
2359:
2347:
2335:
2322:
2320:
2314:
2313:
2311:
2310:
2304:
2299:
2294:
2289:
2277:
2271:
2266:
2261:
2256:
2245:
2239:
2234:
2226:
2219:PARP inhibitor
2215:
2203:
2191:
2179:
2178:
2177:
2172:
2167:
2162:
2150:
2144:
2139:
2134:
2129:
2115:
2102:
2100:
2091:
2087:
2086:
2084:
2083:
2077:
2072:
2067:
2056:
2051:
2046:
2041:
2035:
2033:
2023:
2022:
2019:
2018:
2015:
2014:
2012:
2011:
2005:
2000:
1995:
1985:
1983:
1977:
1976:
1974:
1973:
1967:
1962:
1951:
1946:
1941:
1936:
1924:
1918:
1916:
1910:
1909:
1907:
1906:
1901:
1896:
1891:
1886:
1881:
1875:
1873:
1871:Platinum-based
1867:
1866:
1864:
1863:
1858:
1853:
1848:
1836:
1835:
1829:
1813:
1812:
1807:
1802:
1797:
1787:
1782:
1770:
1769:
1764:
1759:
1749:
1744:
1738:
1729:
1724:
1712:
1710:
1701:
1689:
1688:
1685:
1684:
1682:
1681:
1676:
1671:
1666:
1661:
1655:
1650:
1639:
1633:
1628:
1623:
1618:
1613:
1608:
1598:
1593:
1586:Anthracyclines
1581:
1579:
1569:
1568:
1566:
1565:
1559:
1547:
1545:
1539:
1538:
1536:
1535:
1529:
1524:
1519:
1514:
1509:
1504:
1499:
1494:
1489:
1484:
1472:
1470:
1461:
1449:
1448:
1445:
1444:
1442:
1441:
1428:
1426:
1420:
1419:
1417:
1416:
1410:
1398:
1397:
1384:
1383:
1367:
1366:
1356:
1351:
1346:
1341:
1336:
1324:
1322:
1316:
1315:
1313:
1312:
1306:
1304:Mercaptopurine
1295:
1290:
1285:
1279:
1274:
1258:
1257:
1244:
1242:
1236:
1235:
1233:
1232:
1226:
1215:
1209:
1204:
1199:
1187:
1185:
1176:
1159:
1151:
1150:
1147:
1146:
1144:
1143:
1131:
1125:
1120:
1115:
1110:
1105:
1093:
1091:
1087:
1086:
1084:
1083:
1077:
1072:
1067:
1062:
1050:
1048:
1037:
1021:
1020:
1006:Intracellular
1005:
1003:
1002:
995:
988:
980:
972:
971:
947:
936:www.google.com
923:
909:
890:"Sapacitibine"
874:
850:
832:
808:
779:(8): 373–380.
759:
704:
675:(5): 628–636.
655:
628:(2): 101–107.
611:
610:
608:
605:
581:Daiichi Sankyo
572:
569:
549:lung infection
485:
482:
393:
392:
375:
374:
372:
371:
368:
366:
363:
355:
354:
353:
350:
349:
347:
346:
343:
335:
334:
333:
330:
329:
327:
326:
318:
316:
308:
307:
301:
295:
294:
291:
285:
279:
273:
268:
262:
261:
257:
256:
254:
253:
245:DTXSID90164887
240:
238:
225:
224:
222:
221:
213:
211:
205:
204:
202:
201:
193:
191:
185:
184:
182:
181:
173:
171:
165:
164:
162:
161:
153:
151:
145:
144:
142:
141:
133:
131:
120:
119:
117:
116:
108:
106:
100:
99:
97:
96:
85:
77:
76:
75:
72:
71:
67:
66:
64:
63:
59:
57:
51:
50:
42:
38:
37:
33:
32:
15:
13:
10:
9:
6:
4:
3:
2:
2755:
2744:
2741:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2719:
2716:
2715:
2713:
2694:
2692:
2689:
2688:
2686:
2683:
2680:
2677:
2675:
2672:
2671:
2667:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2637:
2634:
2632:
2629:
2627:
2624:
2622:
2619:
2617:
2614:
2612:
2609:
2607:
2604:
2602:
2599:
2597:
2594:
2592:
2589:
2587:
2584:
2582:
2579:
2576:
2573:
2571:
2567:
2566:
2562:
2560:
2559:Tabelecleucel
2557:
2555:
2552:
2550:
2547:
2545:
2542:
2540:
2537:
2535:
2532:
2530:
2527:
2525:
2522:
2520:
2519:Lurbinectedin
2517:
2515:
2512:
2510:
2507:
2505:
2502:
2500:
2497:
2495:
2492:
2490:
2487:
2485:
2482:
2480:
2477:
2475:
2472:
2470:
2467:
2465:
2462:
2460:
2457:
2455:
2452:
2450:
2447:
2445:
2442:
2440:
2437:
2435:
2432:
2430:
2427:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2399:
2395:
2391:
2390:
2386:
2384:
2381:
2379:
2376:
2374:
2371:
2370:
2368:
2364:
2357:
2353:
2352:
2348:
2345:
2341:
2340:
2336:
2333:
2329:
2328:
2324:
2323:
2321:
2319:
2315:
2308:
2305:
2303:
2300:
2298:
2295:
2293:
2290:
2288:
2284:
2282:
2278:
2275:
2272:
2270:
2267:
2265:
2262:
2260:
2257:
2255:
2251:
2250:
2246:
2243:
2240:
2238:
2235:
2233:
2230:
2227:
2225:
2221:
2220:
2216:
2213:
2209:
2208:
2204:
2201:
2197:
2196:
2192:
2189:
2185:
2184:
2180:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
2157:
2156:
2155:
2151:
2148:
2145:
2143:
2140:
2138:
2135:
2133:
2130:
2128:
2124:
2123:
2120:
2116:
2113:
2109:
2108:
2104:
2103:
2101:
2099:
2095:
2092:
2088:
2081:
2078:
2076:
2073:
2071:
2068:
2066:
2062:
2061:
2057:
2055:
2052:
2050:
2047:
2045:
2042:
2040:
2037:
2036:
2034:
2032:
2028:
2024:
2009:
2006:
2004:
2001:
1999:
1996:
1994:
1990:
1987:
1986:
1984:
1982:
1981:Intercalation
1978:
1971:
1968:
1966:
1963:
1961:
1957:
1956:
1952:
1950:
1947:
1945:
1942:
1940:
1937:
1934:
1930:
1929:
1925:
1923:
1920:
1919:
1917:
1915:
1911:
1905:
1902:
1900:
1897:
1895:
1892:
1890:
1889:Dicycloplatin
1887:
1885:
1882:
1880:
1877:
1876:
1874:
1872:
1868:
1862:
1859:
1857:
1854:
1852:
1849:
1847:
1844:
1842:
1838:
1837:
1833:
1830:
1828:
1824:
1821:
1819:
1815:
1814:
1811:
1808:
1806:
1803:
1801:
1798:
1795:
1791:
1788:
1786:
1783:
1781:
1778:
1776:
1772:
1771:
1768:
1765:
1763:
1762:Prednimustine
1760:
1757:
1753:
1750:
1748:
1745:
1742:
1739:
1737:
1733:
1730:
1728:
1725:
1723:
1720:
1718:
1714:
1713:
1711:
1709:
1705:
1702:
1699:
1694:
1690:
1680:
1677:
1675:
1672:
1670:
1667:
1665:
1662:
1659:
1656:
1654:
1651:
1649:
1645:
1644:
1640:
1637:
1634:
1632:
1629:
1627:
1624:
1622:
1619:
1617:
1614:
1612:
1609:
1606:
1602:
1599:
1597:
1594:
1592:
1588:
1587:
1583:
1582:
1580:
1578:
1577:Intercalation
1574:
1570:
1563:
1560:
1558:
1554:
1553:
1549:
1548:
1546:
1544:
1540:
1533:
1530:
1528:
1525:
1523:
1520:
1518:
1515:
1513:
1510:
1508:
1505:
1503:
1500:
1498:
1495:
1493:
1490:
1488:
1485:
1483:
1479:
1478:
1474:
1473:
1471:
1469:
1465:
1462:
1459:
1454:
1450:
1439:
1435:
1434:
1430:
1429:
1427:
1425:
1421:
1414:
1411:
1409:
1405:
1404:
1400:
1399:
1395:
1391:
1390:
1386:
1385:
1381:
1380:+daunorubicin
1378:
1374:
1373:
1369:
1368:
1364:
1360:
1357:
1355:
1352:
1350:
1347:
1345:
1344:Doxifluridine
1342:
1340:
1337:
1335:
1331:
1330:
1326:
1325:
1323:
1321:
1317:
1310:
1307:
1305:
1301:
1300:
1296:
1294:
1293:Rabacfosadine
1291:
1289:
1286:
1283:
1280:
1278:
1275:
1273:
1269:
1268:
1264:
1260:
1259:
1255:
1251:
1250:
1246:
1245:
1243:
1241:
1237:
1230:
1227:
1225:
1221:
1220:
1216:
1213:
1210:
1208:
1205:
1203:
1200:
1198:
1194:
1193:
1189:
1188:
1186:
1184:
1180:
1177:
1174:
1169:
1163:
1160:
1156:
1152:
1141:
1137:
1136:
1132:
1129:
1126:
1124:
1121:
1119:
1116:
1114:
1111:
1109:
1106:
1104:
1100:
1099:
1095:
1094:
1092:
1088:
1081:
1078:
1076:
1073:
1071:
1068:
1066:
1063:
1061:
1057:
1056:
1052:
1051:
1049:
1046:
1041:
1038:
1035:
1030:
1026:
1022:
1017:
1013:
1009:
1001:
996:
994:
989:
987:
982:
981:
978:
961:
957:
951:
948:
937:
933:
927:
924:
918:
916:
914:
910:
899:. Summer 2016
898:
891:
885:
883:
881:
879:
875:
860:
854:
851:
848:
844:
843:
836:
833:
822:
818:
812:
809:
804:
800:
795:
790:
786:
782:
778:
774:
770:
763:
760:
749:
745:
739:
737:
735:
733:
731:
729:
727:
725:
723:
721:
719:
717:
715:
713:
711:
709:
705:
700:
696:
691:
686:
682:
678:
674:
670:
666:
659:
656:
651:
647:
643:
639:
635:
631:
627:
623:
616:
613:
606:
604:
601:
597:
594:and the U.S.
593:
588:
584:
582:
577:
570:
568:
566:
560:
556:
554:
550:
546:
541:
537:
533:
529:
524:
522:
518:
514:
509:
507:
503:
499:
495:
494:hematological
491:
483:
481:
479:
475:
471:
467:
464:. In a liver
463:
459:
455:
451:
446:
444:
440:
439:cell division
436:
435:DNA synthesis
431:
429:
425:
421:
418:
413:
411:
407:
403:
399:
389:
382:
376:
367:
362:
358:
351:
342:
338:
331:
324:
320:
319:
317:
314:
309:
302:
300:
296:
269:
267:
263:
258:
250:
246:
242:
241:
239:
230:
226:
219:
215:
214:
212:
210:
206:
199:
195:
194:
192:
190:
186:
179:
175:
174:
172:
170:
166:
159:
155:
154:
152:
150:
146:
139:
135:
134:
132:
125:
121:
114:
110:
109:
107:
105:
101:
93:
84:
80:
73:
68:
61:
60:
58:
56:
52:
47:
43:
39:
36:Clinical data
34:
30:
25:
2743:Orphan drugs
2606:Tazemetostat
2570:Alitretinoin
2563:
2474:Estramustine
2454:Elsamitrucin
2444:Eflornithine
2398:Pegaspargase
2394:Asparaginase
2387:
2356:Testolactone
2349:
2337:
2325:
2279:
2264:Panobinostat
2247:
2217:
2205:
2193:
2181:
2152:
2117:
2105:
2058:
2054:Padeliporfin
1993:Dactinomycin
1989:Streptomyces
1970:Temozolomide
1965:Mitozolomide
1953:
1944:Mitobronitol
1933:Procarbazine
1926:
1914:Nonclassical
1839:
1816:
1810:Streptozocin
1775:Nitrosoureas
1773:
1747:Chlorambucil
1741:Trofosfamide
1727:Chlormethine
1722:Bendamustine
1715:
1653:Mitoxantrone
1648:Losoxantrone
1641:
1601:Daunorubicin
1584:
1550:
1487:Camptothecin
1475:
1431:
1401:
1387:
1370:
1354:Fluorouracil
1334:Capecitabine
1327:
1297:
1261:
1247:
1217:
1212:Pralatrexate
1202:Methotrexate
1190:
1133:
1096:
1053:
963:. Retrieved
959:
950:
939:. Retrieved
935:
926:
901:. Retrieved
896:
866:. Retrieved
864:. 2015-06-24
853:
840:
835:
824:. Retrieved
820:
811:
776:
772:
762:
751:. Retrieved
747:
672:
668:
658:
625:
621:
615:
589:
585:
578:
574:
561:
557:
525:
510:
487:
458:solid tumors
447:
432:
423:
414:
398:Sapacitabine
397:
396:
385:
379:
218:CHEBI:145429
91:
45:
21:Sapacitabine
2738:Pyrimidones
2733:Nucleosides
2681:from market
2651:Vorasidenib
2631:Trabectedin
2616:Tiazofurine
2611:Tebentafusp
2596:Tagraxofusp
2554:Plitidepsin
2524:Mitoguazone
2464:Epacadostat
2434:Demecolcine
2378:Aflibercept
2351:Sex steroid
2224:Fuzuloparib
2165:Carfilzomib
2137:Palbociclib
2127:Abemaciclib
2080:Verteporfin
2044:Efaproxiral
1960:Dacarbazine
1922:Altretamine
1904:Satraplatin
1899:Oxaliplatin
1879:Carboplatin
1856:Triaziquone
1827:Mannosulfan
1805:Ranimustine
1785:Fotemustine
1626:Pirarubicin
1611:Doxorubicin
1605:+cytarabine
1591:Aclarubicin
1552:Podophyllum
1477:Camptotheca
1408:Azacitidine
1394:Gemcitabine
1349:Floxuridine
1282:Fludarabine
1277:Clofarabine
1263:Halogenated
1254:Pentostatin
1229:Raltitrexed
1197:Aminopterin
1140:Ixabepilone
1135:Epothilones
1103:Cabazitaxel
1080:Vinorelbine
1065:Vincristine
1060:Vinblastine
1045:microtubule
842:NCT01303796
526:An ongoing
470:gemcitabine
306: g·mol
113:151823-14-2
70:Identifiers
41:Other names
2712:Categories
2646:Verdinexor
2641:Venetoclax
2544:Oblimersen
2539:Navitoclax
2514:Lucanthone
2509:Lonidamine
2499:Lifileucel
2494:Ivosidenib
2489:Imetelstat
2459:Enasidenib
2449:Elesclomol
2414:Bexarotene
2409:Belzutifan
2344:Bexarotene
2332:Atrasentan
2307:Umbralisib
2302:Idelalisib
2292:Copanlisib
2274:Vorinostat
2269:Romidepsin
2259:Entinostat
2254:Belinostat
2212:Masoprocol
2200:Tiazofurin
2188:Anagrelide
2160:Bortezomib
2147:Seliciclib
2142:Ribociclib
2122:inhibitors
2112:Tipifarnib
2075:Temoporfin
2070:Talaporfin
2008:Plicamycin
2003:Mitomycins
1949:Pipobroman
1928:Hydrazines
1894:Nedaplatin
1846:Carboquone
1841:Aziridines
1832:Treosulfan
1780:Carmustine
1767:Uramustine
1736:Ifosfamide
1708:Alkylating
1669:Bisantrene
1658:Pixantrone
1631:Valrubicin
1621:Idarubicin
1616:Epirubicin
1562:Teniposide
1517:Lurtotecan
1512:Irinotecan
1413:Decitabine
1377:Cytarabine
1320:Pyrimidine
1309:Tioguanine
1299:Thiopurine
1288:Nelarabine
1272:Cladribine
1224:Pemetrexed
1207:Pemetrexed
1183:Folic acid
1123:Paclitaxel
1075:Vinflunine
965:2016-11-17
941:2016-11-20
903:2016-11-20
868:2016-11-17
826:2016-11-09
753:2016-11-17
607:References
545:toxicities
536:decitabine
521:seliciclib
466:metastatic
454:anti-tumor
450:metabolite
311:3D model (
299:Molar mass
178:W335P73C3L
149:ChemSpider
104:CAS Number
79:IUPAC name
2691:Phase III
2679:Withdrawn
2656:Vosaroxin
2636:Veliparib
2591:Sotorasib
2581:Selinexor
2575:Tretinoin
2565:Retinoids
2479:Glasdegib
2424:Celecoxib
2373:Adagrasib
2297:Duvelisib
2287:Alpelisib
2242:Rucaparib
2229:Niraparib
2170:Oprozomib
2132:Alvocidib
1998:Bleomycin
1955:Triazenes
1939:Etoglucid
1884:Cisplatin
1800:Nimustine
1794:Semustine
1790:Lomustine
1752:Melphalan
1679:Menogaril
1674:Crisnatol
1664:Amsacrine
1636:Zorubicin
1596:Amrubicin
1557:Etoposide
1532:Topotecan
1527:Silatecan
1522:Rubitecan
1507:Gimatecan
1492:Cositecan
1482:Belotecan
1158:inhibitor
1128:Tesetaxel
1118:Ortataxel
1113:Larotaxel
1108:Docetaxel
1070:Vindesine
553:typhlitis
441:cycle at
2728:Nitriles
2529:Mitotane
2469:Eribulin
2237:Olaparib
2175:Ixazomib
1851:Thiotepa
1823:Busulfan
1502:Exatecan
1339:Carmofur
1047:assembly
1010: /
897:Cyclacel
803:22739266
699:17637678
650:10744649
642:18300755
443:G2 phase
410:leukemia
406:Cyclacel
388:(verify)
55:ATC code
1458:S phase
1359:Tegafur
1173:S phase
1098:Taxanes
1034:M phase
794:3777512
690:2360357
420:prodrug
304:490.645
266:Formula
124:PubChem
2674:WHO-EM
2283:(Pi3K)
1240:Purine
1043:Block
801:
791:
697:
687:
648:
640:
337:SMILES
198:D09722
158:135703
138:153970
2195:IMPDI
2090:Other
893:(PDF)
862:(PDF)
646:S2CID
428:CNDAC
400:is a
357:InChI
313:JSmol
209:ChEBI
94:)-one
2281:PIKI
2249:HDAC
1698:CCNS
799:PMID
695:PMID
638:PMID
565:BRCA
551:and
474:5-FU
189:KEGG
169:UNII
62:none
2327:ERA
2183:PhI
2154:PrI
2119:CDK
2031:PDT
1029:MIs
1025:SPs
1016:L01
789:PMC
781:doi
685:PMC
677:doi
630:doi
472:or
460:in
234:EPA
128:CID
2714::
2687::
2207:LI
2107:FI
1573:II
1543:II
1365:))
958:.
934:.
912:^
895:.
877:^
819:.
797:.
787:.
777:31
775:.
771:.
746:.
707:^
693:.
683:.
673:97
671:.
667:.
644:.
636:.
626:15
624:.
445:.
412:.
280:42
274:26
2577:)
2568:(
2400:)
2396:/
2392:(
2358:)
2354:(
2346:)
2342:(
2334:)
2330:(
2309:)
2285:(
2276:)
2252:(
2244:)
2222:(
2214:)
2210:(
2202:)
2198:(
2190:)
2186:(
2149:)
2125:(
2114:)
2110:(
2082:)
2063:(
2029:/
2010:)
1991:(
1972:)
1958:(
1935:)
1931:(
1843::
1834:)
1825:(
1820::
1796:)
1792:(
1777::
1758:)
1754:(
1743:)
1734:(
1719::
1700:)
1696:(
1660:)
1646:(
1638:)
1607:)
1603:(
1589:(
1575:+
1564:)
1555:(
1534:)
1480:(
1468:I
1460:)
1456:(
1440:)
1436:(
1415:)
1406:(
1396:)
1392:(
1382:)
1375:(
1361:(
1332:(
1311:)
1302:(
1284:)
1270:(
1265:/
1256:)
1252:(
1231:)
1222:(
1214:)
1195:(
1175:)
1171:(
1142:)
1138:(
1130:)
1101:(
1082:)
1058:(
1036:)
1032:(
1027:/
1018:)
1014:(
999:e
992:t
985:v
968:.
944:.
906:.
871:.
829:.
805:.
783::
756:.
701:.
679::
652:.
632::
424:D
315:)
292:5
289:O
286:4
283:N
277:H
271:C
236:)
232:(
92:H
88:D
46:N
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
