436:
BrMT can be seen working in the K channel to prevent the early activation of the channel – before the cooperation has begun. Though its exact mechanism remains unknown, it is expected to work by forcing a conformational change in the pore domain of the channel. This part of the channel is expected to
367:
and has four subunits, which form a pore through which ions flow, carrying type-A potassium current (IA). A mutation in the Sh gene reduces the conductance of charge across the neuron since the channels do not work, causing the severe phenotypical aberrations mentioned above. These types of
437:
be altered instead of the voltage-sensing domain because of its connections to other subunits. When the conformational change is enacted, the BrMT sites on adjacent subunits are also affected, resulting in a widespread delayed activation of the K channel.
387:
protein complex. When confronted with a stimulus, the tetramers undergo conformational changes; some of these changes are cooperative. The final step involved in the opening of the channel is highly synchronized.
316:, the fly’s legs will shake (hence the name); even when the fly is unanaesthetized, it will exhibit aberrant movements. Sh-mutant flies have a shorter lifespan than regular flies; in their
1829:
2739:
559:
Schwarz TL, Tempel BL, Papazian DM, Jan YN, Jan LY (January 1988). "Multiple potassium-channel components are produced by alternative splicing at the Shaker locus in
Drosophila".
391:
The shaker gene has also been identified as a gene that helps determine an organism's amount of sleep. The phenotype of the flies that need less sleep is called minisleep (mns).
2474:
1726:
1659:
981:"Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins"
176:
74:
516:
Tempel BL, Papazian DM, Schwarz TL, Jan YN, Jan LY (August 1987). "Sequence of a probable potassium channel component encoded at Shaker locus of
Drosophila".
109:
3286:
2670:
2653:
2648:
2643:
2638:
3281:
2675:
1773:
1045:
446:
3276:
2727:
1908:
2625:
1646:
1062:
200:
2411:
874:
Cirelli C, Bushey D, Hill S, Huber R, Kreber R, Ganetzky B, Tononi G (April 2005). "Reduced sleep in
Drosophila Shaker mutants".
188:
3004:
2003:
1781:
1097:
663:
403:
channel is affected by various toxins, which effectively slow the opening of the channel, or reversibly block its functioning.
67:
181:
3026:
3235:
1146:
932:"Binding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathway"
2601:
1513:
2876:
1054:
1038:
360:
3230:
1440:
676:
MacKinnon R (March 1991). "Determination of the subunit stoichiometry of a voltage-activated potassium channel".
364:
3220:
1481:
1357:
827:"Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels"
3225:
329:
305:
44:
3256:
1248:
1235:
1222:
1202:
1189:
1154:
979:
Pimentel C, M'Barek S, Visan V, Grissmer S, Sampieri F, Sabatier JM, Darbon H, Fajloun Z (January 2008).
193:
3291:
1031:
356:
465:
Salkoff L, Wyman R (1981). "Genetic modification of potassium channels in
Drosophila Shaker mutants".
1129:
883:
685:
568:
525:
474:
246:
1023:
2596:
1472:
1119:
907:
709:
592:
498:
729:"Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions"
1634:
1010:
961:
899:
856:
807:
758:
701:
641:
610:
Lichtinghagen R, Stocker M, Wittka R, Boheim G, Stühmer W, Ferrus A, Pongs O (December 1990).
584:
541:
490:
325:
321:
2403:
1384:
1000:
992:
951:
943:
891:
846:
838:
797:
789:
748:
740:
693:
631:
623:
576:
533:
482:
241:
250:
2939:
1079:
270:
129:
887:
689:
572:
529:
478:
2735:
1422:
1005:
980:
956:
931:
851:
826:
802:
777:
753:
728:
627:
373:
363:
and are essential to the correct functioning of the cell. A working shaker channel is
636:
612:"Molecular basis of altered excitability in Shaker mutants of Drosophila melanogaster"
611:
3270:
2689:
415:
310:
3042:
2433:
911:
713:
596:
502:
425:
369:
217:
79:
2972:
2967:
2962:
2957:
2844:
2683:
1058:
778:"Activation of Shaker potassium channels. II. Kinetics of the V2 mutant channel"
420:
280:
139:
339:, the shaker gene is located on the X chromosome. The closest human homolog is
2952:
2318:
1686:
1654:
659:
313:
224:
103:
86:
3037:
2947:
537:
1014:
965:
903:
17:
947:
860:
842:
811:
793:
762:
744:
705:
645:
588:
545:
494:
3050:
2398:
1377:
1372:
1367:
1362:
1294:
1289:
996:
410:
384:
229:
91:
895:
3177:
2934:
2770:
1271:
1266:
1261:
300:
2854:
2849:
2583:
2578:
2524:
2519:
2335:
2323:
2313:
2308:
2296:
2291:
2286:
2173:
2168:
2163:
2055:
1991:
1986:
1981:
1976:
1971:
1966:
1961:
1896:
1891:
1881:
1876:
1871:
1822:
1817:
1807:
1802:
1679:
1674:
1669:
1664:
1570:
1565:
1560:
1550:
1545:
1535:
1530:
1460:
1455:
1450:
1445:
1348:
1343:
1338:
1333:
1321:
1316:
1311:
1306:
1215:
1182:
1177:
1172:
1167:
697:
580:
486:
212:
62:
155:
potassium voltage-gated channel, shaker-related subfamily, member 3
3088:
3019:
3014:
3009:
2926:
2913:
2908:
2903:
2898:
2893:
2888:
2839:
2832:
2827:
2822:
2817:
2812:
2807:
2802:
2797:
2785:
2780:
2775:
2765:
2760:
2755:
2750:
2665:
2609:
2566:
2561:
2556:
2551:
2546:
2541:
2536:
2514:
2509:
2504:
2499:
2494:
2489:
2484:
2465:
2460:
2455:
2450:
2438:
2355:
2350:
2345:
2330:
2268:
2263:
2258:
2249:
2244:
2230:
2225:
2216:
2211:
2206:
2197:
2192:
2183:
2178:
2145:
2140:
2135:
2130:
2121:
2112:
2107:
2102:
2093:
2088:
2083:
2078:
2069:
2064:
2050:
2045:
2040:
2035:
2030:
2025:
2020:
1956:
1951:
1946:
1941:
1936:
1931:
1926:
1921:
1886:
1856:
1851:
1846:
1841:
1812:
1761:
1756:
1751:
1746:
1736:
1731:
1711:
1696:
1691:
1606:
1601:
1596:
1591:
1575:
1555:
1540:
1501:
1496:
1491:
1486:
1394:
1389:
1112:
1107:
1102:
340:
317:
169:
154:
3168:
3163:
3158:
3148:
3143:
3138:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3083:
3078:
3073:
3068:
3063:
3058:
2997:
2992:
2987:
2982:
2977:
2883:
2871:
2866:
2861:
2792:
2745:
2709:
2704:
2699:
2694:
2421:
2239:
1797:
1134:
1124:
430:
205:
3198:
2383:
1629:
1417:
1074:
1027:
2722:
2620:
1741:
1701:
303:, causes a variety of atypical behaviors in the fruit fly,
3211:
3035:
2924:
2720:
2618:
2594:
2396:
2002:
1907:
1772:
1645:
1512:
1471:
1433:
1145:
1090:
276:
266:
261:
240:
235:
223:
211:
199:
187:
175:
165:
160:
153:
135:
125:
120:
102:
97:
85:
73:
61:
53:
39:
34:
29:
406:Toxins that affect the shaker K channel include:
925:
923:
921:
1039:
8:
3208:
3195:
2393:
2380:
1642:
1626:
1430:
1414:
1087:
1071:
1046:
1032:
1024:
258:
117:
1004:
955:
850:
825:Schoppa NE, Sigworth FJ (February 1998).
801:
776:Schoppa NE, Sigworth FJ (February 1998).
752:
727:Schoppa NE, Sigworth FJ (February 1998).
635:
457:
355:gene plays a part in the operation of
150:
26:
447:Genetically encoded voltage indicator
7:
2412:Calcium-activated chloride channels
431:6-bromo-2-mercaptotryptamine (BrMT)
1482:Amiloride-sensitive cation channel
628:10.1002/j.1460-2075.1990.tb07890.x
25:
936:The Journal of General Physiology
930:Sack JT, Aldrich RW (July 2006).
831:The Journal of General Physiology
782:The Journal of General Physiology
733:The Journal of General Physiology
324:as well as prolonged exposure to
3005:Voltage-dependent anion channel
1098:Inositol trisphosphate receptor
3287:Genetic diseases and disorders
3027:General bacterial porin family
1:
3282:Drosophila melanogaster genes
3277:Genes on human chromosome 1
320:, the repetitive firing of
3308:
2446:Chloride Channel Accessory
1055:Membrane transport protein
361:integral membrane proteins
3252:
3207:
3194:
2392:
2379:
1641:
1625:
1441:Epithelial sodium channel
1429:
1413:
1086:
1070:
257:
116:
1358:Cation channels of sperm
372:are responsible for the
538:10.1126/science.2441471
330:neuromuscular junctions
306:Drosophila melanogaster
46:Drosophila melanogaster
357:potassium ion channels
1434:Constitutively active
948:10.1085/jgp.200609492
843:10.1085/jgp.111.2.313
794:10.1085/jgp.111.2.295
745:10.1085/jgp.111.2.271
997:10.1110/ps.073122908
3201:By gating mechanism
896:10.1038/nature03486
888:2005Natur.434.1087C
690:1991Natur.350..232M
573:1988Natur.331..137S
530:1987Sci...237..770T
479:1981Natur.293..228S
2728:TRP cation channel
2626:CNG cation channel
1909:Tandem pore domain
1120:Ryanodine receptor
383:channel is a homo
110:X: 17.8 - 17.98 Mb
3264:
3263:
3248:
3247:
3244:
3243:
3236:Stretch-activated
3213:Ion channel class
3190:
3189:
3186:
3185:
2375:
2374:
2371:
2370:
1647:Calcium-activated
1635:Potassium channel
1621:
1620:
1617:
1616:
1409:
1408:
1405:
1404:
882:(7037): 1087–92.
365:voltage-dependent
326:neurotransmitters
322:action potentials
290:
289:
286:
285:
149:
148:
145:
144:
16:(Redirected from
3299:
3209:
3196:
2404:Chloride channel
2394:
2381:
1774:Inward-rectifier
1643:
1627:
1431:
1415:
1385:Two-pore channel
1088:
1072:
1048:
1041:
1034:
1025:
1019:
1018:
1008:
976:
970:
969:
959:
927:
916:
915:
871:
865:
864:
854:
822:
816:
815:
805:
773:
767:
766:
756:
724:
718:
717:
698:10.1038/350232a0
673:
667:
666:
656:
650:
649:
639:
622:(13): 4399–407.
616:The EMBO Journal
607:
601:
600:
581:10.1038/331137a0
567:(6152): 137–42.
556:
550:
549:
513:
507:
506:
487:10.1038/293228a0
473:(5829): 228–30.
462:
259:
151:
118:
49:
27:
21:
3307:
3306:
3302:
3301:
3300:
3298:
3297:
3296:
3267:
3266:
3265:
3260:
3240:
3203:
3182:
3031:
2930:
2920:
2716:
2614:
2590:
2388:
2367:
2281:
2158:
2015:
1998:
1903:
1867:
1837:
1793:
1785:
1768:
1722:
1637:
1613:
1586:
1525:
1508:
1467:
1425:
1401:
1284:
1256:
1243:
1230:
1210:
1197:
1162:
1141:
1082:
1080:Calcium channel
1066:
1052:
1022:
985:Protein Science
978:
977:
973:
929:
928:
919:
873:
872:
868:
824:
823:
819:
775:
774:
770:
726:
725:
721:
684:(6315): 232–5.
675:
674:
670:
658:
657:
653:
609:
608:
604:
558:
557:
553:
524:(4816): 770–5.
515:
514:
510:
464:
463:
459:
455:
443:
397:
349:
43:
23:
22:
15:
12:
11:
5:
3305:
3303:
3295:
3294:
3289:
3284:
3279:
3269:
3268:
3262:
3261:
3253:
3250:
3249:
3246:
3245:
3242:
3241:
3239:
3238:
3233:
3228:
3223:
3217:
3215:
3205:
3204:
3199:
3192:
3191:
3188:
3187:
3184:
3183:
3181:
3180:
3175:
3174:
3173:
3172:
3171:
3166:
3161:
3153:
3152:
3151:
3146:
3141:
3133:
3132:
3131:
3126:
3121:
3116:
3111:
3106:
3101:
3093:
3092:
3091:
3086:
3081:
3076:
3071:
3066:
3061:
3047:
3045:
3033:
3032:
3030:
3029:
3024:
3023:
3022:
3017:
3012:
3002:
3001:
3000:
2995:
2990:
2985:
2980:
2975:
2970:
2965:
2960:
2955:
2944:
2942:
2928:
2922:
2921:
2919:
2918:
2917:
2916:
2911:
2906:
2901:
2896:
2891:
2881:
2880:
2879:
2874:
2864:
2859:
2858:
2857:
2852:
2847:
2837:
2836:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2800:
2790:
2789:
2788:
2783:
2778:
2773:
2768:
2763:
2758:
2753:
2743:
2732:
2730:
2718:
2717:
2715:
2714:
2713:
2712:
2707:
2702:
2697:
2692:
2680:
2679:
2678:
2673:
2668:
2658:
2657:
2656:
2651:
2646:
2641:
2630:
2628:
2616:
2615:
2613:
2612:
2606:
2604:
2602:Proton channel
2592:
2591:
2589:
2588:
2587:
2586:
2581:
2571:
2570:
2569:
2564:
2559:
2554:
2549:
2544:
2539:
2529:
2528:
2527:
2522:
2517:
2512:
2507:
2502:
2497:
2492:
2487:
2477:
2472:
2471:
2470:
2469:
2468:
2463:
2458:
2453:
2443:
2442:
2441:
2436:
2426:
2425:
2424:
2408:
2406:
2390:
2389:
2384:
2377:
2376:
2373:
2372:
2369:
2368:
2366:
2365:
2360:
2359:
2358:
2353:
2348:
2338:
2333:
2328:
2327:
2326:
2321:
2316:
2311:
2301:
2300:
2299:
2294:
2289:
2279:
2274:
2273:
2272:
2271:
2266:
2261:
2254:
2253:
2252:
2247:
2242:
2235:
2234:
2233:
2228:
2221:
2220:
2219:
2214:
2209:
2202:
2201:
2200:
2195:
2188:
2187:
2186:
2181:
2176:
2171:
2166:
2156:
2151:
2150:
2149:
2148:
2143:
2138:
2133:
2126:
2125:
2124:
2117:
2116:
2115:
2110:
2105:
2098:
2097:
2096:
2091:
2086:
2081:
2074:
2073:
2072:
2067:
2060:
2059:
2058:
2053:
2048:
2043:
2038:
2033:
2028:
2023:
2013:
2008:
2006:
2000:
1999:
1997:
1996:
1995:
1994:
1989:
1984:
1979:
1974:
1969:
1964:
1959:
1954:
1949:
1944:
1939:
1934:
1929:
1924:
1913:
1911:
1905:
1904:
1902:
1901:
1900:
1899:
1894:
1889:
1884:
1879:
1874:
1865:
1861:
1860:
1859:
1854:
1849:
1844:
1835:
1827:
1826:
1825:
1820:
1815:
1810:
1805:
1800:
1791:
1787:
1783:
1778:
1776:
1770:
1769:
1767:
1766:
1765:
1764:
1759:
1754:
1749:
1744:
1739:
1734:
1729:
1720:
1716:
1715:
1714:
1706:
1705:
1704:
1699:
1694:
1684:
1683:
1682:
1677:
1672:
1667:
1662:
1651:
1649:
1639:
1638:
1630:
1623:
1622:
1619:
1618:
1615:
1614:
1612:
1611:
1610:
1609:
1604:
1599:
1594:
1584:
1580:
1579:
1578:
1573:
1568:
1563:
1558:
1553:
1548:
1543:
1538:
1533:
1523:
1518:
1516:
1510:
1509:
1507:
1506:
1505:
1504:
1499:
1494:
1489:
1478:
1476:
1469:
1468:
1466:
1465:
1464:
1463:
1458:
1453:
1448:
1437:
1435:
1427:
1426:
1423:Sodium channel
1418:
1411:
1410:
1407:
1406:
1403:
1402:
1400:
1399:
1398:
1397:
1392:
1382:
1381:
1380:
1375:
1370:
1365:
1354:
1353:
1352:
1351:
1346:
1341:
1336:
1326:
1325:
1324:
1319:
1314:
1309:
1299:
1298:
1297:
1292:
1282:
1277:
1276:
1275:
1274:
1269:
1264:
1254:
1246:
1241:
1233:
1228:
1220:
1219:
1218:
1208:
1200:
1195:
1187:
1186:
1185:
1180:
1175:
1170:
1160:
1151:
1149:
1143:
1142:
1140:
1139:
1138:
1137:
1132:
1127:
1117:
1116:
1115:
1110:
1105:
1094:
1092:
1084:
1083:
1075:
1068:
1067:
1053:
1051:
1050:
1043:
1036:
1028:
1021:
1020:
971:
917:
866:
817:
788:(2): 295–311.
768:
719:
668:
651:
602:
551:
508:
456:
454:
451:
450:
449:
442:
439:
434:
433:
428:
423:
418:
413:
396:
393:
374:repolarization
348:
345:
288:
287:
284:
283:
278:
274:
273:
268:
264:
263:
255:
254:
244:
238:
237:
233:
232:
227:
221:
220:
215:
209:
208:
203:
197:
196:
191:
185:
184:
179:
173:
172:
167:
163:
162:
158:
157:
147:
146:
143:
142:
137:
133:
132:
127:
123:
122:
114:
113:
106:
100:
99:
95:
94:
89:
83:
82:
77:
71:
70:
65:
59:
58:
55:
51:
50:
41:
37:
36:
32:
31:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3304:
3293:
3290:
3288:
3285:
3283:
3280:
3278:
3275:
3274:
3272:
3259:
3258:
3251:
3237:
3234:
3232:
3231:Voltage-gated
3229:
3227:
3224:
3222:
3219:
3218:
3216:
3214:
3210:
3206:
3202:
3197:
3193:
3179:
3176:
3170:
3167:
3165:
3162:
3160:
3157:
3156:
3154:
3150:
3147:
3145:
3142:
3140:
3137:
3136:
3134:
3130:
3127:
3125:
3122:
3120:
3117:
3115:
3112:
3110:
3107:
3105:
3102:
3100:
3097:
3096:
3094:
3090:
3087:
3085:
3082:
3080:
3077:
3075:
3072:
3070:
3067:
3065:
3062:
3060:
3057:
3056:
3054:
3053:
3052:
3049:
3048:
3046:
3044:
3041:
3039:
3034:
3028:
3025:
3021:
3018:
3016:
3013:
3011:
3008:
3007:
3006:
3003:
2999:
2996:
2994:
2991:
2989:
2986:
2984:
2981:
2979:
2976:
2974:
2971:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2950:
2949:
2946:
2945:
2943:
2941:
2938:
2936:
2932:
2923:
2915:
2912:
2910:
2907:
2905:
2902:
2900:
2897:
2895:
2892:
2890:
2887:
2886:
2885:
2882:
2878:
2875:
2873:
2870:
2869:
2868:
2865:
2863:
2860:
2856:
2853:
2851:
2848:
2846:
2843:
2842:
2841:
2838:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2799:
2796:
2795:
2794:
2791:
2787:
2784:
2782:
2779:
2777:
2774:
2772:
2769:
2767:
2764:
2762:
2759:
2757:
2754:
2752:
2749:
2748:
2747:
2744:
2741:
2737:
2734:
2733:
2731:
2729:
2726:
2724:
2719:
2711:
2708:
2706:
2703:
2701:
2698:
2696:
2693:
2691:
2688:
2687:
2686:
2685:
2681:
2677:
2674:
2672:
2669:
2667:
2664:
2663:
2662:
2659:
2655:
2652:
2650:
2647:
2645:
2642:
2640:
2637:
2636:
2635:
2632:
2631:
2629:
2627:
2624:
2622:
2617:
2611:
2608:
2607:
2605:
2603:
2600:
2598:
2593:
2585:
2582:
2580:
2577:
2576:
2575:
2572:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2543:
2540:
2538:
2535:
2534:
2533:
2530:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2501:
2498:
2496:
2493:
2491:
2488:
2486:
2483:
2482:
2481:
2478:
2476:
2473:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2448:
2447:
2444:
2440:
2437:
2435:
2432:
2431:
2430:
2427:
2423:
2420:
2419:
2418:
2415:
2414:
2413:
2410:
2409:
2407:
2405:
2402:
2400:
2395:
2391:
2387:
2386:Miscellaneous
2382:
2378:
2364:
2363:Shaker (gene)
2361:
2357:
2354:
2352:
2349:
2347:
2344:
2343:
2342:
2339:
2337:
2336:minK/ISK-like
2334:
2332:
2329:
2325:
2322:
2320:
2317:
2315:
2312:
2310:
2307:
2306:
2305:
2302:
2298:
2295:
2293:
2290:
2288:
2285:
2284:
2283:
2276:
2275:
2270:
2267:
2265:
2262:
2260:
2257:
2256:
2255:
2251:
2248:
2246:
2243:
2241:
2238:
2237:
2236:
2232:
2229:
2227:
2224:
2223:
2222:
2218:
2215:
2213:
2210:
2208:
2205:
2204:
2203:
2199:
2196:
2194:
2191:
2190:
2189:
2185:
2182:
2180:
2177:
2175:
2172:
2170:
2167:
2165:
2162:
2161:
2160:
2153:
2152:
2147:
2144:
2142:
2139:
2137:
2134:
2132:
2129:
2128:
2127:
2123:
2120:
2119:
2118:
2114:
2111:
2109:
2106:
2104:
2101:
2100:
2099:
2095:
2092:
2090:
2087:
2085:
2082:
2080:
2077:
2076:
2075:
2071:
2068:
2066:
2063:
2062:
2061:
2057:
2054:
2052:
2049:
2047:
2044:
2042:
2039:
2037:
2034:
2032:
2029:
2027:
2024:
2022:
2019:
2018:
2017:
2010:
2009:
2007:
2005:
2004:Voltage-gated
2001:
1993:
1990:
1988:
1985:
1983:
1980:
1978:
1975:
1973:
1970:
1968:
1965:
1963:
1960:
1958:
1955:
1953:
1950:
1948:
1945:
1943:
1940:
1938:
1935:
1933:
1930:
1928:
1925:
1923:
1920:
1919:
1918:
1915:
1914:
1912:
1910:
1906:
1898:
1895:
1893:
1890:
1888:
1885:
1883:
1880:
1878:
1875:
1873:
1870:
1869:
1868:
1862:
1858:
1855:
1853:
1850:
1848:
1845:
1843:
1840:
1839:
1838:
1831:
1828:
1824:
1821:
1819:
1816:
1814:
1811:
1809:
1806:
1804:
1801:
1799:
1796:
1795:
1794:
1788:
1786:
1780:
1779:
1777:
1775:
1771:
1763:
1760:
1758:
1755:
1753:
1750:
1748:
1745:
1743:
1740:
1738:
1735:
1733:
1730:
1728:
1725:
1724:
1723:
1717:
1713:
1710:
1709:
1707:
1703:
1700:
1698:
1695:
1693:
1690:
1689:
1688:
1685:
1681:
1678:
1676:
1673:
1671:
1668:
1666:
1663:
1661:
1658:
1657:
1656:
1653:
1652:
1650:
1648:
1644:
1640:
1636:
1633:
1628:
1624:
1608:
1605:
1603:
1600:
1598:
1595:
1593:
1590:
1589:
1588:
1581:
1577:
1574:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1544:
1542:
1539:
1537:
1534:
1532:
1529:
1528:
1527:
1520:
1519:
1517:
1515:
1514:Voltage-gated
1511:
1503:
1500:
1498:
1495:
1493:
1490:
1488:
1485:
1484:
1483:
1480:
1479:
1477:
1474:
1470:
1462:
1459:
1457:
1454:
1452:
1449:
1447:
1444:
1443:
1442:
1439:
1438:
1436:
1432:
1428:
1424:
1421:
1416:
1412:
1396:
1393:
1391:
1388:
1387:
1386:
1383:
1379:
1376:
1374:
1371:
1369:
1366:
1364:
1361:
1360:
1359:
1356:
1355:
1350:
1347:
1345:
1342:
1340:
1337:
1335:
1332:
1331:
1330:
1327:
1323:
1320:
1318:
1315:
1313:
1310:
1308:
1305:
1304:
1303:
1300:
1296:
1293:
1291:
1288:
1287:
1286:
1279:
1278:
1273:
1270:
1268:
1265:
1263:
1260:
1259:
1258:
1250:
1247:
1245:
1237:
1234:
1232:
1224:
1221:
1217:
1214:
1213:
1212:
1204:
1201:
1199:
1191:
1188:
1184:
1181:
1179:
1176:
1174:
1171:
1169:
1166:
1165:
1164:
1156:
1153:
1152:
1150:
1148:
1147:Voltage-gated
1144:
1136:
1133:
1131:
1128:
1126:
1123:
1122:
1121:
1118:
1114:
1111:
1109:
1106:
1104:
1101:
1100:
1099:
1096:
1095:
1093:
1089:
1085:
1081:
1078:
1073:
1069:
1064:
1060:
1056:
1049:
1044:
1042:
1037:
1035:
1030:
1029:
1026:
1016:
1012:
1007:
1002:
998:
994:
991:(1): 107–18.
990:
986:
982:
975:
972:
967:
963:
958:
953:
949:
945:
942:(1): 119–32.
941:
937:
933:
926:
924:
922:
918:
913:
909:
905:
901:
897:
893:
889:
885:
881:
877:
870:
867:
862:
858:
853:
848:
844:
840:
837:(2): 313–42.
836:
832:
828:
821:
818:
813:
809:
804:
799:
795:
791:
787:
783:
779:
772:
769:
764:
760:
755:
750:
746:
742:
739:(2): 271–94.
738:
734:
730:
723:
720:
715:
711:
707:
703:
699:
695:
691:
687:
683:
679:
672:
669:
665:
661:
655:
652:
647:
643:
638:
633:
629:
625:
621:
617:
613:
606:
603:
598:
594:
590:
586:
582:
578:
574:
570:
566:
562:
555:
552:
547:
543:
539:
535:
531:
527:
523:
519:
512:
509:
504:
500:
496:
492:
488:
484:
480:
476:
472:
468:
461:
458:
452:
448:
445:
444:
440:
438:
432:
429:
427:
424:
422:
419:
417:
416:Charybdotoxin
414:
412:
409:
408:
407:
404:
402:
394:
392:
389:
386:
382:
377:
376:of the cell.
375:
371:
366:
362:
358:
354:
346:
344:
342:
338:
333:
331:
327:
323:
319:
315:
312:
308:
307:
302:
298:
296:
282:
279:
275:
272:
269:
265:
260:
256:
253:
252:
248:
245:
243:
239:
234:
231:
228:
226:
222:
219:
216:
214:
210:
207:
204:
202:
198:
195:
192:
190:
186:
183:
180:
178:
174:
171:
168:
164:
159:
156:
152:
141:
138:
134:
131:
128:
124:
119:
115:
112:
111:
107:
105:
101:
96:
93:
90:
88:
84:
81:
78:
76:
75:RefSeq (mRNA)
72:
69:
66:
64:
60:
56:
52:
48:
47:
42:
38:
33:
28:
19:
3292:Ion channels
3254:
3221:Ligand-gated
3212:
3200:
3043:Gap junction
3036:
2925:
2721:
2682:
2660:
2633:
2619:
2595:
2573:
2531:
2479:
2445:
2428:
2416:
2397:
2385:
2362:
2340:
2303:
2277:
2154:
2011:
1916:
1863:
1833:
1789:
1718:
1631:
1582:
1521:
1419:
1328:
1301:
1280:
1252:
1239:
1226:
1206:
1193:
1158:
1091:Ligand-gated
1076:
1059:ion channels
988:
984:
974:
939:
935:
879:
875:
869:
834:
830:
820:
785:
781:
771:
736:
732:
722:
681:
677:
671:
654:
619:
615:
605:
564:
560:
554:
521:
517:
511:
470:
466:
460:
435:
426:Pandinotoxin
405:
400:
398:
390:
380:
378:
370:ion channels
359:, which are
352:
350:
336:
334:
304:
294:
293:
291:
249:
108:
45:
3226:Light-gated
1708:IK channel
421:Iberiotoxin
295:shaker (Sh)
271:Swiss-model
161:Identifiers
130:Swiss-model
35:Identifiers
18:Shaker gene
3271:Categories
2429:Bestrophin
1687:SK channel
1655:BK channel
1329:γ-subunits
1302:β-subunits
1285:δ-subunits
660:HomoloGene
453:References
385:tetrameric
337:Drosophila
314:anesthesia
267:Structures
262:Search for
236:Other data
126:Structures
121:Search for
104:Chromosome
98:Other data
3257:disorders
3255:see also
3038:Cytoplasm
2948:Aquaporin
2417:Anoctamin
2240:11.1/hERG
309:. Under
218:NM_002232
177:NCBI gene
80:NM_167596
3051:Connexin
2331:minK/ISK
1015:18042681
966:16801385
904:15858564
441:See also
411:Agitoxin
401:shaker K
395:Blockers
381:shaker K
347:Function
332:occurs.
281:InterPro
140:InterPro
40:Organism
3178:Innexin
2935:solutes
1006:2144586
957:2151558
912:4370944
884:Bibcode
861:9450946
852:2222769
812:9450945
803:2222768
763:9450944
754:2222764
714:4246808
706:1706481
686:Bibcode
662::
646:1702382
597:4245558
589:2448635
569:Bibcode
546:2441471
526:Bibcode
518:Science
503:4342210
495:6268986
475:Bibcode
301:mutated
277:Domains
225:UniProt
136:Domains
87:UniProt
1475:-gated
1473:Proton
1249:T-type
1236:R-type
1223:Q-type
1203:P-type
1190:N-type
1155:L-type
1013:
1003:
964:
954:
910:
902:
876:Nature
859:
849:
810:
800:
761:
751:
712:
704:
678:Nature
644:
637:552231
634:
595:
587:
561:Nature
544:
501:
493:
467:Nature
318:larvae
247:Chr. 1
230:P22001
213:RefSeq
206:176263
166:Symbol
92:P08510
63:Entrez
54:Symbol
30:Shaker
3089:GJA10
2940:Porin
2840:TRPML
2610:HVCN1
2304:KCNIP
2159:α7-12
1063:TC 1A
908:S2CID
710:S2CID
664:20513
593:S2CID
499:S2CID
341:KCNA3
311:ether
299:when
297:gene,
251:p13.3
242:Locus
170:KCNA3
68:32780
3169:GJD4
3164:GJD3
3159:GJD2
3149:GJC3
3144:GJC2
3139:GJC1
3129:GJB7
3124:GJB6
3119:GJB5
3114:GJB4
3109:GJB3
3104:GJB2
3099:GJB1
3084:GJA9
3079:GJA8
3074:GJA5
3069:GJA4
3064:GJA3
3059:GJA1
2884:TRPV
2867:TRPP
2862:TRPN
2793:TRPM
2746:TRPC
2736:TRPA
2574:CLNS
2532:CLIC
2480:CLCN
2475:CFTR
2422:ANO1
2341:MiRP
2269:12.3
2264:12.2
2259:12.1
2250:11.3
2245:11.2
2231:10.2
2226:10.1
2016:α1-6
1830:GIRK
1244:α2.3
1231:α2.1
1198:α2.2
1011:PMID
962:PMID
900:PMID
857:PMID
808:PMID
759:PMID
702:PMID
642:PMID
585:PMID
542:PMID
491:PMID
399:The
379:The
351:The
292:The
201:OMIM
194:6221
189:HGNC
182:3738
2933:(+
2771:4AP
2684:HCN
2217:9.3
2212:9.2
2207:9.1
2198:8.2
2193:8.1
2184:7.5
2179:7.4
2174:7.3
2169:7.2
2164:7.1
2146:6.4
2141:6.3
2136:6.2
2131:6.1
2122:5.1
2113:4.3
2108:4.2
2103:4.1
2094:3.4
2089:3.3
2084:3.2
2079:3.1
2070:2.2
2065:2.1
2056:1.8
2051:1.7
2046:1.6
2041:1.5
2036:1.4
2031:1.3
2026:1.2
2021:1.1
1917:K2P
1897:7.1
1892:6.2
1887:6.1
1882:5.1
1877:4.2
1872:4.1
1857:3.4
1852:3.3
1847:3.2
1842:3.1
1823:2.6
1818:2.4
1813:2.3
1808:2.2
1803:2.1
1798:1.1
1784:ATP
1762:5.1
1757:4.2
1752:4.1
1747:3.1
1742:2.3
1737:2.2
1732:2.1
1727:1.1
1712:IK1
1702:SK3
1697:SK2
1692:SK1
1571:1.9
1566:1.8
1561:1.7
1556:1.6
1551:1.5
1546:1.4
1541:1.3
1536:1.2
1531:1.1
1420:Na:
1272:3.3
1267:3.2
1262:3.1
1216:2.1
1183:1.4
1178:1.3
1173:1.2
1168:1.1
1077:Ca:
1001:PMC
993:doi
952:PMC
944:doi
940:128
892:doi
880:434
847:PMC
839:doi
835:111
798:PMC
790:doi
786:111
749:PMC
741:doi
737:111
694:doi
682:350
632:PMC
624:doi
577:doi
565:331
534:doi
522:237
483:doi
471:293
335:In
328:at
3273::
3155:D
3135:C
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