260:(IRES) located in 5' untranslated region (5' UTR) to translate their proteins, Shih's group discovered a novel machinery regulating IRES-dependent translation by using IRES RNA to pull down host cell proteins and RNAs. Their findings include the discovery of a novel IRES trans-acting factor (ITAF), far upstream element binding protein 1 (FBP1), which positively regulate EV-A71 IRES activity. Furthermore, Shih's team found that EV-A71 viral proteinase 2A is capable of cleaving FBP1. The cleavage occurs at the Gly-371 residue of FBP1 during the EV-A71 infection process, and this generates a functional cleavage product, FBP11-371, which acts to promote viral IRES activity. Moreover, FBP1 and FBP11-371 could act additively to promote IRES-mediated translation and virus yield. They also identified another protein in the same family, far upstream element binding protein 2 (FBP2), to be a negative regulator for EV71 IRES. However, upon virus infection, FBP2 was cleaved and the truncated FBP2 without C-terminal domain becomes a positive regulator. They further proved that the ubiquitination of FBP2 in its C-terminal domain causes a negative regulation of IRES.
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Shih established a
Molecular Virology Laboratory at Chang Gung University in 1996 and was appointed Medical Director in Clinical Virology Laboratory, Chang Gung Memorial Hospital in 1998. She also established the Research Center for Emerging Viral Infections at Chang Gung University in 2009, and took
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in 2004 and
Outstanding Research Award from Ministry of Science and Technology in 2012 for her contribution to EV-A71 outbreak control and research in Taiwan. More recently, she received a Research Grant Award from the
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Shih's group considers various aspects of emerging RNA viruses, including identification of viral pathogens during outbreaks, mechanistic studies of pathogenesis, and development of vaccines and antiviral agents.
458:"Additive promotion of viral internal ribosomal entry site-mediated translation by far upstream element-binding protein 1 and an enterovirus 71-induced cleavage product"
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poses a threat to global health, Shih's group also conducted research regarding SARS-CoV-2, identifying therapeutic targets and developing diagnostic tools.
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509:"Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral protein synthesis"
775:"Exclusive interview–Research Center for Emerging Viral Infections, Chang Gung University(CGU) Establishing the most complete database for COVID-19"
409:"Far upstream element binding protein 1 binds the internal ribosomal entry site of enterovirus 71 and enhances viral translation and viral growth"
727:"Taiwan and Australia Cooperate Together on Scientific Research to Fight Against Pandemics, and Jointly Develop New Anti-novel Coronavirus Drugs"
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and holds a professorship in the
Department of Medical Biotechnology and Laboratory Science and Graduate Program of Biomedical Sciences at
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Shin-Ru Shih received her bachelor's degree in medical technology and master's degree in biochemistry from
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Department of
Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University
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Huang PN, Lin JY, Locker N, Kung YA, Hung CT, Lin JY, Huang HI, Li ML, Shih SR (2011).
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607:"Control of the downregulating IRES trans-acting factor KSRP by ubiquitination"
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Shih was awarded the
National Medal for Outstanding Young Scientist from the
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Research Center for
Emerging Viral Infections, College of Medicine,
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Hung CT, Kung YA, Lai ML, Brewer G, Liu ST, Shih SR (25 Oct 2016).
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703:"International team-based efforts on stopping new coronavirus"
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Chen LL, Kung YA, Weng KF, Lin JY, Horng JT, Shih SR (2013).
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and her Ph.D. in biochemistry and molecular biology from
384:"Eyes on the next generation, fighting global epidemics"
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Medical biotechnology professor and virologist in Taiwan
655:"Dr. Shin-Ru Shih won RESEARCH GRANTS HFSP AWARDS 2015"
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Rutgers
University, the State University of New Jersey
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may be too technical for most readers to understand
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237:the lead as center director since then.
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252:and regulate viral translation. Since
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121:Linkou Chang Gung Memorial Hospital
119:Department of Laboratory Medicine,
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507:Lin JY, Li ML, Shih SR (2009).
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475:10.1371/journal.ppat.1005959
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815:Taiwanese women scientists
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825:Rutgers University alumni
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244:She identified several
38:, as no other articles
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513:Nucleic Acids Research
413:Nucleic Acids Research
275:More recently, as the
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151:Chang Gung University
116:Chang Gung University
779:gase.most.ntu.edu.tw
574:10.1128/JVI.02278-12
360:"Shih, Shin-Ru, PhD"
623:10.1093/nar/gkw1042
562:Journal of Virology
177:Research and career
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525:10.1093/nar/gkn901
425:10.1093/nar/gkr682
302:"Dr. Shin-Ru Shih"
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111:Institutions
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683:ntnu.edu.tw
364:cgmh.org.tw
799:Categories
784:2021-08-10
760:2021-08-10
736:2021-08-10
731:RCEVI, CGU
712:2021-08-10
707:RCEVI, CGU
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659:RCEVI, CGU
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342:2021-08-10
311:2021-08-10
283:References
256:use their
62:March 2024
53:; try the
40:link to it
250:cytoplasm
161:Education
43:. Please
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