699:
the leukocyte and endothelial cells. When sialyl-Lewis is part of an O-glycan and attached to CD34, it can then bind to L-selectin. For the binding to L-selectin to occur, sialyl-Lewis must undergo sulfation. For sialyl-Lewis to bind to P-selectin, an O-linked glycan near the N-terminus of P-selectin glycoprotein ligand-1 (PSGL-1) is modified with sialyl-Lewis and, in combination with nearby tyrosine residues modified with sulfate, forms the binding contact for P-selectin. For sialyl-Lewis to bind to E-selectin, it can be part of either an N-linked or O-linked glycan attached to cell surface glycoproteins such as PSGL-1, CD43 or CD44. This sialyl-Lewis-mediated binding to selectins allows circulating leukocytes to stick to and roll along endothelial cells lining blood vessels, thereby enabling the leukocytes to accumulate at a site of vascular inflammation.
396:
263:
711:(ZP), the translucent matrix covering the human egg composed of four glycoproteins—ZP1, 2, 3, and 4—and transit through the matrix in order to fuse with the oocyte. The human ZP is coated with dense N- and O-glycans that are terminated with the sialyl-Lewis sequence. The hemizona assay, which assesses sperm–ZP binding by counting the number of sperm bound to hemispheres of bisected nonliving human eggs
33:
137:
796:
in studies to fight tumors and cancer cell growth. There is frequent overexpression of sialyl-Lewis on cancer cells, and it is found on both N-glycan and O-glycans. Sialyl-Lewis is being researched with CD markers to find new ways to create biosensors for cancer cells. It is also being used in new ways to target cancer cells specifically for cancer treatment.
715:, reveals that 0.5 mM sialyl-Lewis inhibits sperm–ZP binding by 63%. Furthermore, adding purified and solubilized ZP3 or ZP4 from the human oocyte dose-dependently inhibits sperm–ZP binding in the hemizona assay. Such evidence suggest that the early steps of human sperm–egg binding may be mediated by lectins for sialyl-Lewis present on human sperm.
516:
419:
InChI=1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1
429:
InChI=1/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1
795:
Sialyl-Lewis plays a critical role in cancer metastasis, facilitating the extravasation of cancer cells out of the bloodstream when they are moving through the body. Its expression is related to tumor stage, recurrence, and overall patient survival. Therefore, sialyl Lewis x is being used as a target
843:
The term "Lewis" in the name comes from a family of people with a red blood cell incompatibility. The studies done on these individuals' red blood cells led to the discovery of sialyl-Lewis. Sialyl-Lewis is an important red blood cell antigen present on the glycolipids on the plasma membrane of the
698:
Sialyl-Lewis is important in leukocyte tethering and rolling. Leukocytes move through the blood stream and then tether themselves to the endothelial wall and roll along the endothelium before potentially exiting into the tissue. Sialyl-Lewis is a necessary partner for the three selectins that bind
1323:
Li, Wentao; Hulswit, Ruben J. G.; Widjaja, Ivy; Raj, V. Stalin; McBride, Ryan; Peng, Wenjie; Widagdo, W.; Tortorici, M. Alejandra; Dieren, Brenda van; Lang, Yifei; Lent, Jan W. M. van; Paulson, James C.; Haan, Cornelis A. M. de; Groot, Raoul J. de; Kuppeveld, Frank J. M. van; Haagmans, Bart L.;
818:
Sialyl-Lewis plays a key role in the inflammatory response and may be used to increase the leukocyte response to infections. Sialyl-Lewis is also an inflammation-associated antigen on liver cells. It is overexpressed on diseased liver cells and can be used as a way to detect liver disease in a
1528:
Pan, Li-Hua; Yamauchi, Kohei; Sawai, Takashi; Nakadate, Toshihide; Kojima, Yuki; Takahashi, Naofumi; Adachi, Keisuke; Kameyama, Akihiko; Inoue, Hiroshi (May 2000). "Inhibition of
Binding of E- and P-selectin to Sialyl-Lewis X Molecule Suppresses the Inflammatory Response in Hypersensitivity
738:
type 2). Defective synthesis can be caused by the loss of fucosyltransferase, impairing the glycosylation of the glycosphingolipid. Sialyl-Lewis is being researched for detection and treatment of immune disorders because of its presence on leukocytes.
831:, the receptor for sulfated sialyl-Lewis oligosaccharide (particularly with α2,3 linkages) was found to be the preferred binding site, both in humans and in dromedary camels, for the coronavirus causing Middle East respiratory syndrome (
755:, found in neutrophils; it is expressed by cells present in Hodgkin disease, some B-cell chronic lymphocytic leukemias, acute lymphoblastic leukemias, and most acute nonlymphocytic leukemias. CD15 is present on almost all
575:
on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which an egg attracts sperm; first, to stick to it, then bond with it and eventually form a zygote.
1273:
Tortorici, M. Alejandra; Walls, Alexandra C.; Lang, Yifei; Wang, Chunyan; Li, Zeshi; Koerhuis, Danielle; Boons, Geert-Jan; Bosch, Berend-Jan; Rey, FĂ©lix A.; de Groot, Raoul J.; Veesler, David (June 2019).
3626:
2450:
1589:
3619:
529:
3612:
2440:
1044:
Pang, Poh-Choo; Chiu, Philip C. N.; et al. (18 August 2011). "Human Sperm
Binding Is Mediated by the Sialyl-Lewisx Oligosaccharide on the Zona Pellucida".
729:
445:
606:
lack its expression and are induced to strongly express sialyl-Lewis upon activation. The sialyl-Lewis determinant is expressed preferentially on activated
1483:
Sarangapani, Krishna K.; Qian, Jin; Chen, Wei; Zarnitsyna, Veronika I.; Mehta, Padmaja; Yago, Tadayuki; McEver, Rodger P.; Zhu, Cheng (16 September 2011).
2420:
3282:
1606:
1582:
1558:
Essentials of
Glycobiology 3rd Edition, Chapter 14: "Structures Common to Different Glycans" https://www.ncbi.nlm.nih.gov/books/NBK453042/#_Ch14_s2_
1448:
Etzioni, Amos; Frydman, Moshe; Pollack, Shimon; Avidor, Israeli; Phillips, M. Laurie; Paulson, James C.; Gershoni-Baruch, Ruth (17 December 1992).
3930:
3013:
1105:
Chiu, P. C. N.; Wong, B. S. T.; Chung, M. -K.; Lam, K. K. W.; Pang, R. T. K.; Lee, K. -F.; Sumitro, S. B.; Gupta, S. K.; Yeung, W. S. B. (2008).
3001:
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779:; the latter does not stain Reed–Sternberg cells, but does stain almost all other lymphoid cells. Sialyl-Lewis is also present in about 50% of
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3060:
3006:
2786:
1567:
4071:
2519:
2445:
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767:. Reed–Sternberg cells display a characteristic pattern of sialyl-Lewis positivity, with membranous staining combined with staining of the
3548:
3543:
3538:
3533:
2460:
3513:
1198:
410:
116:
1107:"Effects of Native Human Zona Pellucida Glycoproteins 3 and 4 on Acrosome Reaction and Zona Pellucida Binding of Human Spermatozoa"
1397:"Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes"
707:
Sialyl-Lewis allows a sperm cell to recognize and fertilize an egg cell. For fertilization to occur, human sperm must bind to the
2749:
3317:
2811:
2497:
50:
2956:
2492:
810:
Sialyl-Lewis is being used to achieve greater rates of fertilization of eggs in women by coating the eggs with sialyl-Lewis.
97:
54:
1216:"Clinicopathological and prognostic significance of sialyl Lewis X overexpression in patients with cancer: a meta-analysis"
69:
3818:
3453:
2925:
2920:
2865:
2599:
2048:
735:
3147:
2870:
1326:"Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein"
353:
4076:
2465:
583:
and is displayed on the terminus of glycolipids that are present on the cell surface. The sialyl-Lewis determinant, E-
374:
208:)-5-Acetamido-2-{oxy}hexan-3-yl]oxy}-2,4-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-6-oxane-2-carboxylic acid
76:
3635:
3177:
1602:
848:
536:
4061:
2043:
83:
3227:
2122:
314:
756:
1146:
Kerr MA, Stocks SC (November 1992). "The role of CD15-(Le(X))-related carbohydrates in neutrophil adhesion".
320:
4027:
3191:
43:
65:
4081:
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3785:
3775:
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2534:
2529:
2524:
2514:
1821:
1749:
805:
283:
4056:
3688:
1878:
1796:
856:
187:
149:
851:. Clusters of differentiation are a naming system devised in 1982 to classify cell-surface antigens on
764:
3115:
2828:
1408:
1337:
1053:
771:. Immunohistochemical panels for the diagnosis of Hodgkin's disease typically employ CD15 along with
760:
654:
580:
391:
4066:
3142:
2961:
639:
229:
2549:
2283:
1373:
1171:
1087:
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to identify the presence of such cells in biopsies. The presence of these cells is diagnostic of
650:
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1516:
1471:
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1365:
1305:
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1194:
1163:
1128:
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972:
954:
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468:
303:
90:
362:
239:
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1918:
1913:
1836:
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768:
645:. Its systematic name is 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-
395:
3604:
1412:
1341:
1057:
3915:
3744:
3703:
3167:
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2100:
1903:
1511:
1484:
1431:
1396:
1360:
1325:
1300:
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1250:
1215:
977:
942:
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Its localization to the cell surface of cells led to its alternative nomenclature as a
780:
708:
507:
4050:
3887:
3859:
3137:
2594:
1685:
1377:
1091:
649:-acetylglucosamine (Neu5Acα2-3Galβ1-4GlcNAcβ). In humans, it is synthesized by four
3493:
2801:
2791:
2322:
2288:
1175:
784:
748:
568:
342:
1123:
1106:
453:
O=C(N1(O)C(O1(O)(O)CO)(O2(O)(O(CO)2O)O((O3O((O)(O)3O)C)(C=O)NC(=O)C)(O)CO)C(=O)O)C
1562:
1542:
3710:
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3152:
2930:
2905:
2604:
2226:
2152:
1626:
1466:
1449:
943:"Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers"
907:
890:
631:
588:
32:
1395:
Chen, G.-Y.; Osada, H.; Santamaria-Babi, L. F.; Kannagi, R. (7 November 2006).
3719:
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3157:
2838:
2579:
2455:
2088:
2083:
2078:
1933:
1717:
1291:
852:
752:
603:
495:
294:
1450:"Recurrent Severe Infections Caused by a Novel Leukocyte Adhesion Deficiency"
1241:
968:
916:
734:
Defective synthesis of the sialyl-Lewis antigen results in immunodeficiency (
17:
3272:
3267:
3262:
3252:
3247:
3242:
3237:
1501:
1421:
1350:
1276:"Structural basis for human coronavirus attachment to sialic acid receptors"
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1001:
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1083:
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959:
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de Vries, T.; Knegtel, R. M.; Holmes, E. H.; Macher, B. A. (October 2001).
1475:
1167:
759:, including their rare mononuclear variants, and, as such, can be used in
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2475:
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615:
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592:
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2110:
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1002:"The role of carbohydrate recognition during human sperm-egg binding"
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274:
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Except where otherwise noted, data are given for materials in their
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262:
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1189:
Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003).
941:
Trinchera, Marco; Aronica, Adele; Dall’Olio, Fabio (2017-02-23).
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2159:
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and mediates inflammatory extravasation of these cells. Resting
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1700:
1695:
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1621:
1193:(2nd ed.). Greenwich Medical Media, Ltd. pp. 83–84.
685:, participate in the synthesis of the sialyl-Lewis precursor.
587:
ligand carbohydrate structure, is constitutively expressed on
26:
379:
1531:
American
Journal of Respiratory and Critical Care Medicine
783:
cells and can be used to distinguish such conditions from
1485:"Regulation of Catch Bonds by Rate of Force Application"
524:
1563:
Stephen J Isles, Molecule of the Month: Sialyl Lewis X
1214:
Liang, Jin-xiao; Liang, Yong; Gao, Wei (2016-05-24).
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3200:
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2356:
2016:
1614:
57:. Unsourced material may be challenged and removed.
891:"Fucosyltransferases: structure/function studies"
630:Sialyl-Lewis is a tetrasaccharide composed of a
341:
1401:Proceedings of the National Academy of Sciences
1330:Proceedings of the National Academy of Sciences
579:Sialyl-Lewis is also one of the most important
238:
3620:
1583:
730:Congenital disorder of glycosylation type IIc
8:
859:. Sialyl-Lewis was assigned the name CD15.
3935:
3878:
3732:
3649:
3627:
3613:
3605:
1590:
1576:
1568:
835:), the sixth coronavirus to be described.
394:
302:
128:
1607:list of human clusters of differentiation
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1500:
1465:
1430:
1420:
1359:
1349:
1299:
1280:Nature Structural & Molecular Biology
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1231:
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976:
958:
906:
361:
117:Learn how and when to remove this message
881:
450:
415:
390:
319:
1039:
1037:
827:In June 2019, before the onset of the
169:-non-2-ulopyranosylonic acid)-(2→3)-β-
422:Key: LAQPKDLYOBZWBT-NYLDSJSYSA-N
282:
7:
1324:Bosch, Berend-Jan (3 October 2017).
936:
934:
55:adding citations to reliable sources
432:Key: LAQPKDLYOBZWBT-NYLDSJSYBC
332:
561:stage-specific embryonic antigen 1
25:
669:. The other three enzymes of the
514:
135:
31:
1489:Journal of Biological Chemistry
1454:New England Journal of Medicine
787:, which is typically negative.
571:which is usually attached to O-
510:(at 25 °C , 100 kPa).
42:needs additional citations for
553:cluster of differentiation 15s
1:
1191:Manual of Diagnostic Cytology
1124:10.1095/biolreprod.108.069344
736:leukocyte adhesion deficiency
724:Leukocyte adhesion deficiency
217:sialyl Le, SLe, CD15s, SSEA-1
1543:10.1164/ajrccm.161.5.9812016
4072:Clusters of differentiation
1603:clusters of differentiation
1467:10.1056/NEJM199212173272505
500:820.744 g/mol
4098:
3636:Cluster of differentiation
849:cluster of differentiation
803:
727:
1292:10.1038/s41594-019-0233-y
908:10.1093/glycob/11.10.119r
814:Immunity and inflammation
504:
461:
441:
406:
222:
214:
186:
173:-galactopyranosyl-(1→4)--
153:(5-Acetamido-3,5-dideoxy-
148:
143:
134:
823:MERS coronavirus binding
567:), is a tetrasaccharide
1502:10.1074/jbc.M111.240044
1422:10.1073/pnas.0607926103
1351:10.1073/pnas.1712592114
1220:OncoTargets and Therapy
1111:Biology of Reproduction
1066:10.1126/science.1207438
1529:Pneumonitis in Mice".
960:10.3390/biology6010016
806:In vitro fertilization
800:In vitro fertilization
747:Sialyl-Lewis mediates
1019:10.1093/humrep/des447
1000:Clark, G. F. (2013).
857:monoclonal antibodies
804:Further information:
719:Clinical significance
188:Systematic IUPAC name
761:immunohistochemistry
757:Reed–Sternberg cells
581:blood group antigens
51:improve this article
1495:(37): 32749–32761.
1413:2006PNAS..10316894C
1407:(45): 16894–16899.
1342:2017PNAS..114E8508L
1336:(40): E8508–E8517.
1233:10.2147/OTT.S102389
1058:2011Sci...333.1761P
1052:(6050): 1761–1764.
651:fucosyltransferases
549:Sialyl Lewis (sLeX)
131:
4077:Human reproduction
1160:10.1007/BF01046353
1006:Human Reproduction
765:Hodgkin's lymphoma
643:-acetyllactosamine
537:Infobox references
129:
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4002:All (pan-myeloid)
3997:
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3602:
3601:
1460:(25): 1789–1792.
901:(10): 119R–128R.
829:COVID-19 pandemic
791:Cancer metastasis
671:sialyltransferase
545:Chemical compound
543:
542:
375:CompTox Dashboard
264:Interactive image
180:
172:
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127:
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119:
101:
16:(Redirected from
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4062:Tetrasaccharides
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3622:
3615:
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1537:(5): 1689–1697.
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1095:
1077:
1041:
1032:
1031:
1021:
997:
991:
990:
980:
962:
938:
929:
928:
910:
886:
694:Leukocyte homing
551:, also known as
527:
521:
518:
517:
469:Chemical formula
399:
398:
383:
381:
365:
345:
334:
323:
306:
286:
266:
242:
178:
170:
162:
154:
139:
132:
122:
115:
111:
108:
102:
100:
66:"Sialyl-Lewis X"
59:
35:
27:
21:
4097:
4096:
4092:
4091:
4090:
4088:
4087:
4086:
4047:
4046:
4045:
4040:
4018:
3993:
3970:
3925:
3886:
3864:
3844:
3828:
3800:
3724:
3639:
3633:
3603:
3598:
3402:
3196:
2945:
2629:
2352:
2012:
1610:
1596:
1527:
1482:
1447:
1394:
1391:
1389:Further reading
1386:
1385:
1322:
1321:
1317:
1272:
1271:
1267:
1213:
1212:
1208:
1201:
1188:
1187:
1183:
1145:
1144:
1140:
1104:
1103:
1099:
1043:
1042:
1035:
999:
998:
994:
940:
939:
932:
888:
887:
883:
878:
865:
855:identified via
841:
825:
816:
808:
802:
793:
769:Golgi apparatus
745:
732:
726:
721:
705:
696:
691:
628:
619:
611:
546:
539:
534:
533:
532: ?)
523:
519:
515:
511:
489:
485:
481:
477:
471:
457:
454:
449:
448:
437:
434:
433:
430:
424:
423:
420:
414:
413:
402:
384:
377:
368:
348:
335:
309:
289:
269:
256:
245:
232:
218:
210:
209:
182:
130:Sialyl-Lewis X
123:
112:
106:
103:
60:
58:
48:
36:
23:
22:
15:
12:
11:
5:
4095:
4093:
4085:
4084:
4079:
4074:
4069:
4064:
4059:
4049:
4048:
4042:
4041:
4039:
4038:
4032:
4030:
4024:
4023:
4020:
4019:
4017:
4016:
4011:
4005:
4003:
3999:
3998:
3995:
3994:
3992:
3991:
3986:
3980:
3978:
3972:
3971:
3969:
3968:
3959:
3954:
3944:
3942:
3933:
3927:
3926:
3924:
3923:
3918:
3913:
3908:
3903:
3898:
3892:
3890:
3876:
3870:
3869:
3866:
3865:
3863:
3862:
3856:
3854:
3850:
3849:
3846:
3845:
3843:
3842:
3836:
3834:
3830:
3829:
3827:
3826:
3821:
3816:
3810:
3808:
3802:
3801:
3799:
3798:
3793:
3788:
3783:
3778:
3773:
3768:
3763:
3757:
3756:
3751:
3745:Pan-T antigens
3741:
3739:
3730:
3726:
3725:
3723:
3722:
3717:
3707:
3706:
3701:
3696:
3691:
3686:
3681:
3674:
3673:
3668:
3658:
3656:
3647:
3641:
3640:
3634:
3632:
3631:
3624:
3617:
3609:
3600:
3599:
3597:
3596:
3591:
3586:
3581:
3576:
3571:
3566:
3561:
3556:
3551:
3546:
3541:
3536:
3531:
3526:
3521:
3516:
3511:
3506:
3501:
3496:
3491:
3486:
3481:
3476:
3471:
3466:
3461:
3456:
3451:
3446:
3441:
3436:
3431:
3426:
3421:
3416:
3410:
3408:
3404:
3403:
3401:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3360:
3355:
3350:
3345:
3340:
3335:
3330:
3325:
3320:
3315:
3310:
3305:
3300:
3295:
3290:
3285:
3280:
3275:
3270:
3265:
3260:
3255:
3250:
3245:
3240:
3235:
3230:
3225:
3220:
3215:
3210:
3204:
3202:
3198:
3197:
3195:
3194:
3189:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3140:
3135:
3134:
3133:
3128:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3047:
3038:
3033:
3032:
3031:
3026:
3016:
3011:
3010:
3009:
3004:
2994:
2989:
2984:
2979:
2974:
2969:
2964:
2959:
2953:
2951:
2947:
2946:
2944:
2943:
2938:
2933:
2928:
2923:
2918:
2913:
2908:
2903:
2898:
2893:
2888:
2883:
2878:
2873:
2868:
2863:
2858:
2857:
2856:
2851:
2841:
2836:
2831:
2826:
2825:
2824:
2819:
2814:
2804:
2799:
2794:
2789:
2784:
2783:
2782:
2777:
2767:
2762:
2757:
2752:
2747:
2742:
2737:
2736:
2735:
2730:
2720:
2714:
2709:
2704:
2699:
2690:
2685:
2684:
2683:
2678:
2673:
2663:
2658:
2653:
2648:
2643:
2637:
2635:
2631:
2630:
2628:
2627:
2622:
2617:
2612:
2607:
2602:
2597:
2592:
2587:
2582:
2577:
2572:
2567:
2562:
2557:
2552:
2547:
2542:
2537:
2532:
2527:
2522:
2517:
2512:
2507:
2502:
2501:
2500:
2495:
2485:
2484:
2483:
2478:
2468:
2463:
2458:
2453:
2448:
2443:
2438:
2433:
2428:
2423:
2418:
2413:
2408:
2407:
2406:
2401:
2391:
2386:
2381:
2376:
2371:
2366:
2360:
2358:
2354:
2353:
2351:
2350:
2345:
2340:
2335:
2330:
2325:
2320:
2315:
2310:
2301:
2296:
2291:
2286:
2281:
2276:
2275:
2274:
2269:
2264:
2259:
2254:
2249:
2239:
2234:
2229:
2224:
2219:
2214:
2213:
2212:
2207:
2197:
2192:
2187:
2182:
2177:
2172:
2167:
2162:
2157:
2156:
2155:
2150:
2145:
2140:
2135:
2130:
2120:
2119:
2118:
2113:
2108:
2098:
2093:
2092:
2091:
2086:
2081:
2071:
2066:
2061:
2056:
2051:
2046:
2041:
2036:
2031:
2026:
2020:
2018:
2014:
2013:
2011:
2010:
2005:
2004:
2003:
1998:
1993:
1988:
1983:
1978:
1968:
1963:
1958:
1953:
1948:
1943:
1938:
1937:
1936:
1931:
1926:
1921:
1911:
1906:
1901:
1896:
1891:
1886:
1881:
1876:
1871:
1866:
1865:
1864:
1859:
1849:
1844:
1839:
1834:
1829:
1824:
1819:
1814:
1809:
1804:
1799:
1794:
1789:
1784:
1779:
1778:
1777:
1772:
1762:
1757:
1752:
1747:
1746:
1745:
1740:
1735:
1730:
1720:
1715:
1710:
1709:
1708:
1698:
1693:
1688:
1683:
1678:
1677:
1676:
1671:
1666:
1656:
1651:
1650:
1649:
1644:
1639:
1634:
1629:
1618:
1616:
1612:
1611:
1597:
1595:
1594:
1587:
1580:
1572:
1566:
1565:
1560:
1555:
1525:
1480:
1445:
1390:
1387:
1384:
1383:
1315:
1286:(6): 481–489.
1265:
1206:
1199:
1181:
1154:(11): 811–26.
1138:
1117:(5): 869–877.
1097:
1033:
1012:(3): 566–577.
992:
930:
880:
879:
877:
874:
873:
872:
871:(sialyl-Lewis)
864:
861:
840:
837:
824:
821:
815:
812:
801:
798:
792:
789:
781:adenocarcinoma
744:
741:
728:Main article:
725:
722:
720:
717:
709:zona pellucida
704:
701:
695:
692:
690:
687:
627:
624:
617:
609:
544:
541:
540:
535:
513:
512:
508:standard state
505:
502:
501:
498:
492:
491:
487:
483:
479:
475:
472:
467:
464:
463:
459:
458:
456:
455:
452:
444:
443:
442:
439:
438:
436:
435:
431:
428:
427:
425:
421:
418:
417:
409:
408:
407:
404:
403:
401:
400:
392:DTXSID60913167
387:
385:
373:
370:
369:
367:
366:
358:
356:
350:
349:
347:
346:
338:
336:
328:
325:
324:
321:sialyl+Lewis+X
317:
311:
310:
308:
307:
299:
297:
291:
290:
288:
287:
279:
277:
271:
270:
268:
267:
259:
257:
250:
247:
246:
244:
243:
235:
233:
228:
225:
224:
220:
219:
216:
212:
211:
191:
190:
184:
183:
152:
146:
145:
141:
140:
125:
124:
39:
37:
30:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4094:
4083:
4082:Tumor markers
4080:
4078:
4075:
4073:
4070:
4068:
4065:
4063:
4060:
4058:
4055:
4054:
4052:
4037:
4034:
4033:
4031:
4029:
4025:
4015:
4012:
4010:
4007:
4006:
4004:
4000:
3990:
3987:
3985:
3982:
3981:
3979:
3977:
3973:
3967:
3963:
3960:
3958:
3955:
3953:
3949:
3946:
3945:
3943:
3941:
3937:
3934:
3932:
3928:
3922:
3919:
3917:
3914:
3912:
3909:
3907:
3904:
3902:
3899:
3897:
3894:
3893:
3891:
3889:
3888:Myelomonocyte
3884:
3880:
3877:
3875:
3871:
3861:
3858:
3857:
3855:
3851:
3841:
3838:
3837:
3835:
3831:
3825:
3822:
3820:
3817:
3815:
3812:
3811:
3809:
3807:
3803:
3797:
3794:
3792:
3789:
3787:
3784:
3782:
3779:
3777:
3774:
3772:
3769:
3767:
3764:
3762:
3759:
3758:
3755:
3752:
3750:
3746:
3743:
3742:
3740:
3738:
3734:
3731:
3727:
3721:
3718:
3716:
3712:
3709:
3708:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3676:
3675:
3672:
3669:
3667:
3663:
3660:
3659:
3657:
3655:
3651:
3648:
3646:
3642:
3637:
3630:
3625:
3623:
3618:
3616:
3611:
3610:
3607:
3595:
3592:
3590:
3587:
3585:
3582:
3580:
3577:
3575:
3572:
3570:
3567:
3565:
3562:
3560:
3557:
3555:
3552:
3550:
3547:
3545:
3542:
3540:
3537:
3535:
3532:
3530:
3527:
3525:
3522:
3520:
3517:
3515:
3512:
3510:
3507:
3505:
3502:
3500:
3497:
3495:
3492:
3490:
3487:
3485:
3482:
3480:
3477:
3475:
3472:
3470:
3467:
3465:
3462:
3460:
3457:
3455:
3452:
3450:
3447:
3445:
3442:
3440:
3437:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3411:
3409:
3405:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3361:
3359:
3356:
3354:
3351:
3349:
3346:
3344:
3341:
3339:
3336:
3334:
3331:
3329:
3326:
3324:
3321:
3319:
3316:
3314:
3311:
3309:
3306:
3304:
3301:
3299:
3296:
3294:
3291:
3289:
3286:
3284:
3281:
3279:
3276:
3274:
3271:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3246:
3244:
3241:
3239:
3236:
3234:
3231:
3229:
3226:
3224:
3221:
3219:
3216:
3214:
3211:
3209:
3206:
3205:
3203:
3199:
3193:
3190:
3188:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3139:
3136:
3132:
3129:
3127:
3124:
3123:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3051:
3048:
3046:
3042:
3039:
3037:
3034:
3030:
3027:
3025:
3022:
3021:
3020:
3017:
3015:
3012:
3008:
3005:
3003:
3000:
2999:
2998:
2995:
2993:
2990:
2988:
2985:
2983:
2980:
2978:
2975:
2973:
2970:
2968:
2965:
2963:
2960:
2958:
2955:
2954:
2952:
2948:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2855:
2852:
2850:
2847:
2846:
2845:
2842:
2840:
2837:
2835:
2832:
2830:
2827:
2823:
2820:
2818:
2815:
2813:
2810:
2809:
2808:
2805:
2803:
2800:
2798:
2795:
2793:
2790:
2788:
2785:
2781:
2778:
2776:
2773:
2772:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2734:
2731:
2729:
2726:
2725:
2724:
2721:
2718:
2715:
2713:
2710:
2708:
2705:
2703:
2700:
2698:
2694:
2691:
2689:
2686:
2682:
2679:
2677:
2674:
2672:
2669:
2668:
2667:
2664:
2662:
2659:
2657:
2654:
2652:
2649:
2647:
2644:
2642:
2639:
2638:
2636:
2632:
2626:
2623:
2621:
2618:
2616:
2613:
2611:
2608:
2606:
2603:
2601:
2598:
2596:
2593:
2591:
2588:
2586:
2583:
2581:
2578:
2576:
2573:
2571:
2568:
2566:
2563:
2561:
2558:
2556:
2553:
2551:
2548:
2546:
2543:
2541:
2538:
2536:
2533:
2531:
2528:
2526:
2523:
2521:
2518:
2516:
2513:
2511:
2508:
2506:
2503:
2499:
2496:
2494:
2491:
2490:
2489:
2486:
2482:
2479:
2477:
2474:
2473:
2472:
2469:
2467:
2464:
2462:
2459:
2457:
2454:
2452:
2449:
2447:
2444:
2442:
2439:
2437:
2434:
2432:
2429:
2427:
2424:
2422:
2419:
2417:
2414:
2412:
2409:
2405:
2402:
2400:
2397:
2396:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2361:
2359:
2355:
2349:
2346:
2344:
2341:
2339:
2336:
2334:
2331:
2329:
2326:
2324:
2321:
2319:
2316:
2314:
2311:
2309:
2305:
2302:
2300:
2297:
2295:
2292:
2290:
2287:
2285:
2282:
2280:
2277:
2273:
2270:
2268:
2265:
2263:
2260:
2258:
2255:
2253:
2250:
2248:
2245:
2244:
2243:
2240:
2238:
2235:
2233:
2230:
2228:
2225:
2223:
2220:
2218:
2215:
2211:
2208:
2206:
2203:
2202:
2201:
2198:
2196:
2193:
2191:
2188:
2186:
2183:
2181:
2178:
2176:
2173:
2171:
2168:
2166:
2163:
2161:
2158:
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1226:: 3113–3125.
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1200:1-84110-100-1
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743:Blood cancers
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107:November 2023
99:
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68: –
67:
63:
62:Find sources:
56:
52:
46:
45:
40:This article
38:
34:
29:
28:
19:
18:Sialyl-LewisX
4057:Amino sugars
3120:
3040:
3018:
2996:
2843:
2806:
2769:
2722:
2692:
2665:
2487:
2393:
2241:
1970:
1722:
1534:
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1329:
1318:
1283:
1279:
1268:
1223:
1219:
1209:
1190:
1184:
1151:
1148:Histochem. J
1147:
1141:
1114:
1110:
1100:
1049:
1045:
1009:
1005:
995:
950:
946:
898:
895:Glycobiology
894:
884:
846:
842:
826:
817:
809:
794:
785:mesothelioma
749:phagocytosis
746:
733:
712:
706:
697:
646:
640:
629:
589:granulocytes
578:
569:carbohydrate
564:
560:
556:
552:
548:
547:
284:ChEMBL375586
223:Identifiers
215:Other names
205:
201:
197:
193:
181:-glucosamine
174:
166:
158:
113:
104:
94:
87:
80:
73:
61:
49:Please help
44:verification
41:
3711:plasma cell
3694:CD23/FcεRII
632:sialic acid
614:but not on
604:lymphocytes
462:Properties
4067:Acetamides
4051:Categories
3666:CD10/CALLA
3662:Pre-B cell
3638:by lineage
1605:(see also
876:References
853:leukocytes
753:chemotaxis
496:Molar mass
363:0PS35WG8U3
295:ChemSpider
251:3D model (
240:98603-84-0
230:CAS Number
150:IUPAC name
77:newspapers
4028:Stem cell
3819:CD56/NCAM
1242:1178-6930
969:2079-7737
953:(1): 16.
917:0959-6658
819:patient.
626:Structure
593:monocytes
3689:CD21/CR2
3677:mature:
3645:Lymphoid
1599:Proteins
1551:10806176
1521:21775439
1441:17075044
1378:20912646
1370:28923942
1310:31160783
1260:27307752
1133:18667750
1092:23610213
1084:21852454
1028:23315069
987:28241499
925:11588153
863:See also
713:in vitro
689:Function
673:family,
585:selectin
177:-acetyl-
3940:CFU-Meg
3874:Myeloid
3806:NK cell
3407:301–350
3201:251–300
3153:CD240CE
2950:201–250
2634:151–200
2357:101–150
1512:3173187
1476:1279426
1432:1629005
1409:Bibcode
1361:5635925
1338:Bibcode
1301:6554059
1251:4888715
1176:8602651
1168:1362195
1054:Bibcode
1046:Science
978:5372009
947:Biology
839:History
683:ST3GAL6
679:ST3GAL4
675:ST3GAL3
638:and an
620:2 cells
612:1 cells
573:glycans
530:what is
528: (
490:
330:PubChem
167:galacto
159:glycero
91:scholar
3883:CFU-GM
3737:T cell
3654:B cell
3414:CD300A
3373:CDw293
3158:CD240D
3019:CD213a
2997:CDw210
2962:CD202b
2936:CDw199
2931:CDw198
2585:CD140b
2017:51–100
1549:
1519:
1509:
1474:
1439:
1429:
1376:
1368:
1358:
1308:
1298:
1258:
1248:
1240:
1197:
1174:
1166:
1131:
1090:
1082:
1026:
985:
975:
967:
923:
915:
869:CA19-9
844:cell.
681:, and
636:fucose
565:SSEA-1
525:verify
522:
446:SMILES
343:643990
304:559072
275:ChEMBL
144:Names
93:
86:
79:
72:
64:
3976:CFU-E
3896:CD11c
3720:CD138
3699:CD127
3671:CD79A
3594:CD350
3589:CD349
3584:CD344
3579:CD340
3574:CD339
3569:CD338
3564:CD337
3559:CD336
3554:CD335
3549:CD334
3544:CD333
3539:CD332
3534:CD331
3529:CD329
3524:CD328
3519:CD327
3514:CD326
3509:CD325
3504:CD324
3499:CD322
3494:CD321
3489:CD320
3484:CD318
3479:CD317
3474:CD316
3469:CD315
3464:CD314
3459:CD312
3454:CD309
3449:CD307
3444:CD306
3439:CD305
3434:CD304
3429:CD303
3424:CD302
3419:CD301
3398:CD299
3393:CD298
3388:CD297
3383:CD295
3378:CD294
3368:CD292
3363:CD290
3358:CD289
3353:CD288
3348:CD286
3343:CD284
3338:CD283
3333:CD282
3328:CD281
3323:CD280
3318:CD279
3313:CD278
3308:CD276
3303:CD275
3298:CD274
3293:CD273
3288:CD272
3283:CD271
3278:CD269
3273:CD268
3268:CD267
3263:CD266
3258:CD265
3253:CD264
3248:CD263
3243:CD262
3238:CD261
3233:CD258
3228:CD257
3223:CD256
3218:CD254
3213:CD253
3208:CD252
3192:CD249
3187:CD248
3183:CD247
3178:CD246
3173:CD244
3168:CD243
3163:CD241
3148:CD239
3143:CD238
3138:CD236
3121:CD235
3116:CD234
3111:CD233
3106:CD230
3101:CD229
3096:CD228
3091:CD227
3086:CD226
3081:CD225
3076:CD224
3071:CD223
3066:CD222
3061:CD221
3056:CD220
3041:CD218
3036:CD217
3014:CD212
2992:CD209
2987:CD208
2982:CD207
2977:CD206
2972:CD205
2967:CD204
2957:CD201
2941:CD200
2926:CD197
2921:CD196
2916:CD195
2911:CD194
2906:CD193
2901:CD192
2896:CD191
2891:CD186
2886:CD185
2881:CD184
2876:CD183
2871:CD182
2866:CD181
2861:CD180
2844:CD179
2839:CD178
2834:CD177
2829:CD174
2807:CD172
2802:CD171
2797:CD170
2792:CD169
2787:CD168
2770:CD167
2765:CD166
2760:CD164
2755:CD163
2750:CD162
2745:CD161
2740:CD160
2723:CD159
2693:CD158
2688:CD157
2666:CD156
2661:CD155
2656:CD154
2651:CD153
2646:CD152
2641:CD151
2625:CD150
2620:CD148
2615:CD147
2610:CD146
2605:CD144
2600:CD143
2595:CD142
2590:CD141
2580:CD138
2575:CD137
2570:CD136
2565:CD135
2560:CD134
2555:CD133
2550:CD132
2545:CD131
2540:CD130
2535:CD129
2530:CD127
2525:CD126
2520:CD125
2515:CD124
2510:CD123
2505:CD122
2488:CD121
2471:CD120
2466:CD119
2461:CD118
2456:CD117
2451:CD116
2446:CD115
2441:CD114
2436:CD113
2431:CD112
2426:CD111
2421:CD110
2416:CD109
2411:CD108
2394:CD107
2389:CD106
2384:CD105
2379:CD104
2374:CD103
2369:CD102
2364:CD101
2348:CD100
1374:S2CID
1172:S2CID
1088:S2CID
559:) or
557:CD15s
411:InChI
253:JSmol
98:JSTOR
84:books
4036:CD34
4014:CD33
4009:CD13
3989:CD71
3984:CD36
3966:CD61
3962:CD41
3957:CD42
3952:CD36
3948:CD34
3921:CD68
3916:CD64
3911:CD31
3906:CD15
3901:CD14
3824:CD57
3814:CD16
3796:CD28
3791:CD27
3786:CD26
3781:CD18
3776:CD13
3729:T/NK
3715:CD38
3704:CD40
3684:CD20
3679:CD19
2343:CD99
2338:CD98
2333:CD97
2328:CD96
2323:CD95
2318:CD94
2313:CD93
2308:CD92
2304:CD91
2299:CD90
2294:CD89
2289:CD88
2284:CD87
2279:CD86
2242:CD85
2237:CD84
2232:CD83
2227:CD82
2222:CD81
2217:CD80
2200:CD79
2195:CD78
2190:CD74
2185:CD73
2180:CD72
2175:CD71
2170:CD70
2165:CD69
2160:CD68
2123:CD66
2101:CD64
2096:CD63
2074:CD62
2069:CD61
2064:CD59
2059:CD58
2054:CD57
2049:CD56
2044:CD55
2039:CD54
2034:CD53
2029:CD52
2024:CD51
2008:CD50
1971:CD49
1966:CD48
1961:CD47
1956:CD46
1951:CD45
1946:CD44
1941:CD43
1914:CD42
1909:CD41
1904:CD40
1899:CD39
1894:CD38
1889:CD37
1884:CD36
1879:CD35
1874:CD34
1869:CD33
1852:CD32
1847:CD31
1842:CD30
1837:CD29
1832:CD28
1827:CD27
1822:CD26
1817:CD25
1812:CD24
1807:CD23
1802:CD22
1797:CD21
1792:CD20
1787:CD19
1782:CD18
1765:CD16
1760:CD15
1755:CD14
1750:CD13
1723:CD11
1718:CD10
1615:1–50
1547:PMID
1517:PMID
1472:PMID
1437:PMID
1366:PMID
1306:PMID
1256:PMID
1238:ISSN
1195:ISBN
1164:PMID
1129:PMID
1080:PMID
1024:PMID
983:PMID
965:ISSN
921:PMID
913:ISSN
833:MERS
777:CD45
775:and
773:CD30
751:and
667:FUT7
665:and
663:FUT6
659:FUT5
655:FUT3
599:and
591:and
354:UNII
315:MeSH
70:news
3931:MEP
3860:CD5
3853:All
3840:CD2
3833:All
3771:CD8
3766:CD4
3761:CD1
3754:CD7
3749:CD3
1713:CD9
1701:CD8
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1691:CD6
1686:CD5
1681:CD4
1659:CD3
1654:CD2
1627:a-c
1622:CD1
1539:doi
1535:161
1507:PMC
1497:doi
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1417:doi
1405:103
1356:PMC
1346:doi
1334:114
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1288:doi
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1228:doi
1156:doi
1119:doi
1070:hdl
1062:doi
1050:333
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955:doi
903:doi
380:EPA
333:CID
161:-α-
53:by
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482:N
478:H
474:C
382:)
378:(
255:)
206:R
202:R
198:S
194:S
179:D
175:N
171:D
165:-
163:D
157:-
155:D
120:)
114:(
109:)
105:(
95:·
88:·
81:·
74:·
47:.
20:)
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