453:
42:
4063:
694:
Biotech, Inc.) which also markets the product in the United States. Janssen markets golimumab in Canada, Central and South
America, the Middle East, Africa and Asia Pacific. In the European Union, Russia, and Turkey, golimumab distribution rights are held by MSD (Ireland), a subsidiary of Merck &
672:
Golimumab binds to both soluble and transmembrane forms of TNFα. The antibody was isolated from a hybridoma clone produced by transgenic mice immunized with human TNFα. The golimumab-secreting clone was selected after being assayed for human light and heavy chains and TNFα-binding. The commercial
1418:
Tosh J, Archer R, Davis S, Stevenson M, Stevens JW (August 2013). "Golimumab for the treatment of rheumatoid arthritis after the failure of previous disease-modifying antirheumatic drugs: a NICE single technology appraisal".
1345:
272:
1462:
Williams VL, Cohen PR (May 2011). "TNF alpha antagonist-induced lupus-like syndrome: report and review of the literature with implications for treatment with alternative TNF alpha antagonists".
3008:
1179:
4113:
227:
1196:
1077:
523:
717:
4083:
1353:
621:. Golimumab was approved for the treatment by the US Food and Drug Administration (FDA) as well as the European Medicines Agency (EMA) in 2013 for the treatment of
1078:"Simponi (golimumab) Receives FDA Approval as First Once-Monthly Anti-TNF for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis"
125:
1566:
4093:
3001:
4098:
720:(NICE) stated that treatment with golimumab is recommended for RA patients who have failed prior TNFi treatment. Unlike other TNFi treatments such as
68:
2482:
1002:"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update"
953:"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update"
2994:
1153:
4017:
1054:
The selection and use of essential medicines 2023: web annex A: World Health
Organization model list of essential medicines: 23rd list (2023)
716:
was more effective than methotrexate alone. When clinically indicated, golimumab is estimated as a moderate cost-effective treatment option.
628:
Golimumab is approved in Canada and the United States as a once monthly subcutaneous treatment for adults with moderately to severely active
594:
1183:
930:
1375:
Oldfield V, Plosker GL (2009). "Golimumab: in the treatment of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis".
583:
2425:
1795:
653:
1180:"Health Canada Approves Simponi (Golimumab) For Treatment Of Rheumatoid Arthritis, Psoriatic Arthritis And Ankylosing Spondylitis"
1559:
866:
840:
2834:
257:
157:
4108:
3989:
1505:
Rifkin LM, Birnbaum AD, Goldstein DA (August 2013). "TNF inhibition for ophthalmic indications: current status and outlook".
586:(VEGF) demonstrates golimumab as an effective modulator of inflammatory markers and bone metabolism. Golimumab is given via
637:
3999:
1631:
381:
4034:
1740:
1552:
709:
559:
176:
1208:
4053:
1610:
3583:
2288:
1049:
904:
695:
Co., Inc. In Japan, Indonesia, and Taiwan, distribution rights are held by
Mitsubishi Tanabe Pharma Corporation.
606:
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4103:
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213:
448:
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641:
618:
587:
555:
430:
220:
1346:"Simponi Receives European Commission Approval For Treatment Of Non-Radiographic Axial Spondyloarthritis"
807:"FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)"
3095:
3017:
2655:
3299:
1544:
806:
629:
610:
1876:
1244:
Maxwell LJ, Zochling J, Boonen A, Singh JA, Veras MM, Tanjong
Ghogomu E, et al. (April 2015).
1157:
633:
614:
551:
325:
78:
61:
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1400:
1213:
725:
622:
567:
187:
50:. The heavy and light chain fragments are coloured blue and yellow, respectively. From PDB entry
2865:
2723:
2875:
2561:
2002:
1000:
Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, et al. (March 2014).
951:
Smolen JS, Landewé R, Breedveld FC, Buch M, Burmester G, Dougados M, et al. (March 2014).
927:
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47:
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563:
441:
298:
149:
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in patients with rheumatoid arthritis have shown that golimumab in combination with
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2017:
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240:
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673:
product is produced in a recombinant cell line cultured by continuous perfusion.
135:
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2110:
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1982:
1972:
1967:
1962:
1951:
1941:
1846:
1758:
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1695:
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1638:
728:, there have been no reported cases of drug-induced lupus-like syndrome (DILS).
143:
3954:
3933:
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3903:
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2104:
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2012:
2007:
1997:
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1936:
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1916:
1900:
1841:
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1770:
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721:
504:
365:
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3398:
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129:
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17:
1526:
1483:
1440:
1396:
1331:
1269:
1139:
1035:
986:
792:
1313:
928:
Statement On A Nonproprietary Name
Adopted By The USAN Council – Golimumab
774:
33:
3267:
3190:
3100:
3070:
2885:
2760:
2449:
1957:
1867:
1803:
1725:
1283:
345:
171:
1062:
354:
3744:
3629:
2378:
1120:
737:
95:
90:
736:
There is preliminary evidence for golimumab as a treatment option for
3969:
2693:
2524:
575:
421:
410:
2392:
2245:
1245:
548:
83:
2364:
2312:
2273:
2259:
1813:
1687:
579:
401:
307:
279:
2990:
1548:
292:
166:
2221:
814:
609:(EMA) has approved the use of golimumab as a treatment for
266:
198:
1154:"Johnson & Johnson Reports 2008 First-Quarter Results"
652:
The most common adverse reactions (incidence >5%) are
562:(TNF-alpha), a pro-inflammatory molecule and hence is a
595:
530:
4051:
1102:
Löwenberg M, de Boer NK, Hoentjen F (12 March 2014).
3977:
3967:
3947:
3876:
3810:
3801:
3770:
3442:
3374:
3308:
3037:
3028:
2753:
2681:
2654:
2539:
2182:
1884:
1875:
1866:
1859:
1812:
1794:
1785:
1739:
1670:
1600:
1591:
1104:"Golimumab for the treatment of ulcerative colitis"
835:
833:
831:
503:
464:
459:
440:
420:
400:
380:
364:
344:
324:
319:
256:
251:
226:
212:
186:
156:
142:
124:
116:
106:
101:
89:
77:
67:
60:
46:Cartoon representation of the antibody golimumab's
718:National Institutes for Health and Care Excellence
1246:"TNF-alpha inhibitors for ankylosing spondylitis"
1209:"FDA clears potential blockbuster arthritis drug"
333:
894:
892:
890:
888:
4114:World Health Organization essential medicines
3002:
1560:
8:
175:
32:
1250:The Cochrane Database of Systematic Reviews
3974:
3807:
3034:
3009:
2995:
2987:
1881:
1872:
1863:
1791:
1597:
1567:
1553:
1545:
1108:Clinical and Experimental Gastroenterology
451:
40:
1321:
1129:
1119:
1061:
1025:
976:
782:
389:
4084:Drugs developed by Johnson & Johnson
841:"Simponi- golimumab injection, solution"
4058:
749:
353:
148:
442:
31:
1282:
1056:. Geneva: World Health Organization.
574:, intercellaular adhesion molecules (
429:
134:
7:
1464:International Journal of Dermatology
239:
409:
4099:Drugs developed by Merck & Co.
4094:Drugs developed by Schering-Plough
867:"Simponi Aria- golimumab solution"
584:vascular endothelial growth factor
25:
1284:FDA Professional Drug Information
654:upper respiratory tract infection
4061:
1476:10.1111/j.1365-4632.2011.04871.x
1389:10.2165/00063030-200923020-00005
1296:Mazumdar S, Greenwald D (2009).
1006:Annals of the Rheumatic Diseases
957:Annals of the Rheumatic Diseases
757:Mazumdar S, Greenwald D (2009).
482:
476:
1352:(Press release). Archived from
1018:10.1136/annrheumdis-2013-204573
969:10.1136/annrheumdis-2013-204573
1262:10.1002/14651858.CD005468.pub2
494:
488:
470:
1:
638:juvenile idiopathic arthritis
1632:dihydroorotate dehydrogenase
939:American Medical Association
710:randomized controlled trials
578:1, matrix metalloproteinase
556:immunosuppressive medication
543:, sold under the brand name
1611:purine synthesis inhibitors
686:Golimumab was developed by
560:tumor necrosis factor alpha
4130:
1066:. WHO/MHP/HPS/EML/2023.02.
570:(CRP) levels, interleukin
460:Chemical and physical data
4012:
1796:IL-1 receptor antagonists
1519:10.1007/s40259-013-0022-9
1433:10.1007/s40273-013-0052-7
1050:World Health Organization
905:European Medicines Agency
607:European Medicines Agency
520:
39:
2669:Anti-lymphocyte globulin
933:20 February 2012 at the
662:injection site reactions
566:. Profound reduction in
2664:Anti-thymocyte globulin
1576:Immunosuppressive drugs
2469:Interleukin-6 receptor
1895:Complement component 5
642:ankylosing spondylitis
619:ankylosing spondylitis
588:subcutaneous injection
221:Subcutaneous injection
4109:Monoclonal antibodies
3096:Camidanlumab tesirine
3018:Monoclonal antibodies
1350:Johnson & Johnson
1314:10.4161/mabs.1.5.9286
775:10.4161/mabs.1.5.9286
112:Simponi, Simponi Aria
3771:Chimeric + humanized
3300:Nivolumab/relatlimab
1197:FDA Approves Simponi
708:Large, double-blind
704:Rheumatoid arthritis
630:rheumatoid arthritis
611:rheumatoid arthritis
558:. Golimumab targets
554:which is used as an
1186:on 2 February 2010.
909:. 17 September 2018
847:. 30 September 2019
738:ocular inflammation
677:Society and culture
634:psoriatic arthritis
615:psoriatic arthritis
552:monoclonal antibody
288:(Prescription only)
275:(Prescription only)
62:Monoclonal antibody
36:
27:Pharmaceutical drug
4039:Never to phase III
3485:Certolizumab pegol
3452:Immunosuppressive:
2826:Diroximel fumarate
2499:IL-2 receptor/CD25
1927:Certolizumab pegol
1580:Immunosuppressants
1214:North County Times
1121:10.2147/CEG.S48741
726:certolizumab pegol
623:ulcerative colitis
568:C-reactive protein
4049:
4048:
4008:
4007:
3963:
3962:
3797:
3796:
3752:Immune activation
3244:Immune activation
3046:Immunosuppression
2984:
2983:
2831:Efgartigimod alfa
2821:Dimethyl fumarate
2749:
2748:
2677:
2676:
2650:
2649:
1855:
1854:
1781:
1780:
1622:Mycophenolic acid
1421:PharmacoEconomics
1160:on 7 October 2008
690:, Inc. (formerly
538:
537:
311:
296:
283:
270:
202:
169:
48:variable fragment
16:(Redirected from
4121:
4066:
4065:
4064:
4057:
3975:
3808:
3366:Zolimomab aritox
3356:Telimomab aritox
3035:
3011:
3004:
2997:
2988:
2627:Telimomab aritox
2530:Zolimomab aritox
2351:CD62L/L-selectin
2089:Immunoglobulin E
1882:
1873:
1864:
1792:
1598:
1569:
1562:
1555:
1546:
1539:
1538:
1502:
1496:
1495:
1459:
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1452:
1415:
1409:
1408:
1372:
1366:
1365:
1363:
1361:
1342:
1336:
1335:
1325:
1293:
1287:
1286:
1280:
1274:
1273:
1241:
1235:
1234:
1232:
1230:
1223:Associated Press
1205:
1199:
1194:
1188:
1187:
1182:. Archived from
1176:
1170:
1169:
1167:
1165:
1156:. Archived from
1150:
1144:
1143:
1133:
1123:
1099:
1093:
1092:
1090:
1088:
1074:
1068:
1067:
1065:
1046:
1040:
1039:
1029:
997:
991:
990:
980:
948:
942:
925:
919:
918:
916:
914:
896:
883:
882:
880:
878:
873:. 2 October 2020
863:
857:
856:
854:
852:
837:
826:
825:
823:
821:
811:nctr-crs.fda.gov
803:
797:
796:
786:
754:
534:
533:
526:
515:
513:
496:
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55:
44:
37:
35:
21:
4129:
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4124:
4123:
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4120:
4119:
4118:
4089:Janssen Biotech
4074:
4073:
4072:
4062:
4060:
4052:
4050:
4045:
4044:
4029:Clinical trials
4004:
3959:
3943:
3872:
3793:
3784:Rozanolixizumab
3772:
3766:
3758:
3747:
3560:Lulizumab pegol
3438:
3370:
3304:
3024:
3015:
2985:
2980:
2926:Rozanolixizumab
2811:Deucravacitinib
2745:
2673:
2646:
2535:
2184:
2178:
1886:
1851:
1808:
1787:
1777:
1735:
1675:
1666:
1602:Antimetabolites
1593:
1587:
1573:
1543:
1542:
1504:
1503:
1499:
1461:
1460:
1456:
1417:
1416:
1412:
1374:
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1369:
1359:
1357:
1344:
1343:
1339:
1295:
1294:
1290:
1281:
1277:
1256:(4): CD005468.
1243:
1242:
1238:
1228:
1226:
1225:. 24 April 2009
1219:Lee Enterprises
1207:
1206:
1202:
1195:
1191:
1178:
1177:
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1048:
1047:
1043:
999:
998:
994:
950:
949:
945:
935:Wayback Machine
926:
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829:
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756:
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746:
734:
706:
701:
688:Janssen Biotech
684:
679:
670:
658:nasopharyngitis
650:
648:Adverse effects
603:
529:
527:
524:(what is this?)
521:
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28:
23:
22:
15:
12:
11:
5:
4127:
4125:
4117:
4116:
4111:
4106:
4104:TNF inhibitors
4101:
4096:
4091:
4086:
4076:
4075:
4071:
4070:
4047:
4046:
4043:
4042:
4041:
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4026:
4020:
4014:
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4010:
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4002:
3997:
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3773:
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3749:
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3727:
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3712:
3707:
3702:
3697:
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3687:
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3632:
3627:
3622:
3617:
3612:
3607:
3602:
3597:
3592:
3587:
3584:+hyaluronidase
3577:
3572:
3567:
3562:
3557:
3552:
3547:
3542:
3537:
3532:
3527:
3522:
3517:
3512:
3507:
3502:
3497:
3492:
3487:
3482:
3477:
3472:
3467:
3462:
3457:
3448:
3446:
3440:
3439:
3437:
3436:
3431:
3426:
3421:
3416:
3411:
3406:
3401:
3396:
3391:
3386:
3380:
3378:
3372:
3371:
3369:
3368:
3363:
3358:
3353:
3348:
3343:
3338:
3333:
3328:
3323:
3318:
3312:
3310:
3306:
3305:
3303:
3302:
3292:
3291:
3286:
3281:
3271:
3270:
3265:
3260:
3255:
3250:
3240:
3239:
3234:
3229:
3224:
3219:
3214:
3209:
3204:
3199:
3194:
3188:
3183:
3178:
3173:
3168:
3163:
3158:
3153:
3148:
3143:
3138:
3133:
3128:
3123:
3118:
3113:
3108:
3103:
3098:
3093:
3088:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3041:
3039:
3032:
3026:
3025:
3016:
3014:
3013:
3006:
2999:
2991:
2982:
2981:
2979:
2978:
2973:
2968:
2963:
2958:
2953:
2948:
2943:
2938:
2933:
2928:
2923:
2918:
2913:
2908:
2903:
2898:
2893:
2888:
2883:
2878:
2873:
2868:
2863:
2858:
2853:
2848:
2843:
2838:
2835:+hyaluronidase
2828:
2823:
2818:
2816:Deuruxolitinib
2813:
2808:
2803:
2798:
2793:
2788:
2783:
2778:
2773:
2768:
2763:
2757:
2755:
2751:
2750:
2747:
2746:
2744:
2743:
2738:
2733:
2728:
2727:
2726:
2721:
2709:
2708:
2707:
2702:
2689:
2687:
2679:
2678:
2675:
2674:
2672:
2671:
2666:
2660:
2658:
2652:
2651:
2648:
2647:
2645:
2644:
2639:
2634:
2629:
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
2584:
2579:
2574:
2569:
2564:
2559:
2554:
2549:
2543:
2541:
2537:
2536:
2534:
2533:
2520:
2519:
2518:
2517:
2512:
2507:
2494:
2493:
2492:
2491:
2479:
2478:
2477:
2465:
2464:
2463:
2458:
2446:
2445:
2444:
2439:
2434:
2422:
2421:
2420:
2409:
2408:
2407:
2406:
2401:
2389:
2388:
2387:
2375:
2374:
2373:
2361:
2360:
2359:
2347:
2346:
2345:
2340:
2328:
2327:
2326:
2321:
2309:
2308:
2307:
2302:
2297:
2292:
2289:+hyaluronidase
2282:
2270:
2269:
2268:
2256:
2255:
2254:
2242:
2241:
2240:
2235:
2230:
2218:
2217:
2216:
2211:
2206:
2201:
2188:
2186:
2180:
2179:
2177:
2176:
2175:
2174:
2161:
2160:
2159:
2158:
2153:
2132:
2131:
2130:
2129:
2116:
2115:
2114:
2113:
2100:
2099:
2098:
2097:
2084:
2083:
2082:
2081:
2068:
2067:
2066:
2065:
2060:
2055:
2050:
2045:
2040:
2035:
2030:
2025:
2020:
2015:
2010:
2005:
2000:
1995:
1990:
1985:
1980:
1975:
1970:
1965:
1960:
1947:
1946:
1945:
1944:
1939:
1934:
1929:
1924:
1919:
1906:
1905:
1904:
1903:
1890:
1888:
1879:
1870:
1861:
1857:
1856:
1853:
1852:
1850:
1849:
1844:
1839:
1834:
1829:
1824:
1818:
1816:
1810:
1809:
1807:
1806:
1800:
1798:
1789:
1783:
1782:
1779:
1778:
1776:
1775:
1774:
1773:
1765:PDE4 inhibitor
1761:
1756:
1751:
1745:
1743:
1737:
1736:
1734:
1733:
1728:
1722:
1721:
1720:
1719:
1714:
1709:
1704:
1683:
1681:
1668:
1667:
1665:
1664:
1663:
1662:
1649:
1648:
1647:
1646:
1641:
1627:
1626:
1625:
1624:
1619:
1606:
1604:
1595:
1589:
1588:
1574:
1572:
1571:
1564:
1557:
1549:
1541:
1540:
1497:
1454:
1410:
1367:
1356:on 19 May 2016
1337:
1288:
1275:
1236:
1200:
1189:
1171:
1145:
1094:
1069:
1041:
1012:(3): 492–509.
992:
963:(3): 492–509.
943:
920:
900:"Simponi EPAR"
884:
858:
827:
798:
748:
747:
745:
742:
733:
730:
705:
702:
700:
697:
683:
680:
678:
675:
669:
666:
649:
646:
602:
599:
536:
535:
518:
517:
507:
501:
500:
497:
491:
485:
479:
473:
468:
462:
461:
457:
456:
446:
438:
437:
435:
434:
426:
424:
418:
417:
415:
414:
406:
404:
398:
397:
395:
394:
386:
384:
378:
377:
375:
374:
370:
368:
362:
361:
359:
358:
350:
348:
342:
341:
339:
338:
330:
328:
322:
321:
317:
316:
314:
313:
304:
289:
276:
262:
260:
254:
253:
249:
248:
246:
245:
232:
230:
224:
223:
218:
216:administration
210:
209:
207:
206:
204:
194:
192:
184:
183:
181:
180:
162:
160:
154:
153:
146:
140:
139:
132:
122:
121:
118:
114:
113:
110:
104:
103:
99:
98:
93:
87:
86:
81:
75:
74:
73:Whole antibody
71:
65:
64:
58:
57:
45:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4126:
4115:
4112:
4110:
4107:
4105:
4102:
4100:
4097:
4095:
4092:
4090:
4087:
4085:
4082:
4081:
4079:
4069:
4059:
4055:
4038:
4036:
4033:
4032:
4030:
4027:
4024:
4021:
4019:
4016:
4015:
4011:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3982:
3980:
3976:
3973:
3971:
3968:Inflammatory
3966:
3956:
3953:
3952:
3950:
3946:
3940:
3939:Tildrakizumab
3937:
3935:
3932:
3930:
3927:
3925:
3922:
3920:
3917:
3915:
3912:
3910:
3907:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3881:
3879:
3875:
3869:
3866:
3864:
3861:
3859:
3856:
3854:
3851:
3849:
3846:
3844:
3841:
3839:
3836:
3834:
3831:
3829:
3826:
3824:
3821:
3819:
3816:
3815:
3813:
3809:
3806:
3804:
3800:
3790:
3787:
3785:
3782:
3780:
3777:
3776:
3774:
3769:
3765:
3764:
3761:
3757:
3753:
3746:
3743:
3741:
3740:Vobarilizumab
3738:
3736:
3733:
3731:
3728:
3726:
3723:
3721:
3718:
3716:
3713:
3711:
3708:
3706:
3703:
3701:
3698:
3696:
3693:
3691:
3688:
3686:
3685:Spartalizumab
3683:
3681:
3678:
3676:
3673:
3671:
3668:
3666:
3663:
3661:
3658:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3616:
3613:
3611:
3610:Pembrolizumab
3608:
3606:
3603:
3601:
3598:
3596:
3593:
3591:
3588:
3585:
3581:
3578:
3576:
3573:
3571:
3570:Mogamulizumab
3568:
3566:
3563:
3561:
3558:
3556:
3553:
3551:
3548:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3516:
3513:
3511:
3508:
3506:
3503:
3501:
3498:
3496:
3493:
3491:
3490:Crizanlizumab
3488:
3486:
3483:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3450:
3449:
3447:
3445:
3441:
3435:
3432:
3430:
3427:
3425:
3422:
3420:
3417:
3415:
3412:
3410:
3407:
3405:
3402:
3400:
3397:
3395:
3392:
3390:
3387:
3385:
3384:Andecaliximab
3382:
3381:
3379:
3377:
3373:
3367:
3364:
3362:
3359:
3357:
3354:
3352:
3349:
3347:
3344:
3342:
3339:
3337:
3334:
3332:
3329:
3327:
3324:
3322:
3319:
3317:
3314:
3313:
3311:
3307:
3301:
3297:
3294:
3293:
3290:
3287:
3285:
3282:
3280:
3276:
3273:
3272:
3269:
3266:
3264:
3261:
3259:
3256:
3254:
3251:
3249:
3245:
3242:
3241:
3238:
3235:
3233:
3230:
3228:
3225:
3223:
3220:
3218:
3215:
3213:
3210:
3208:
3205:
3203:
3200:
3198:
3195:
3192:
3189:
3187:
3184:
3182:
3179:
3177:
3174:
3172:
3169:
3167:
3164:
3162:
3159:
3157:
3154:
3152:
3149:
3147:
3144:
3142:
3139:
3137:
3134:
3132:
3129:
3127:
3124:
3122:
3119:
3117:
3114:
3112:
3109:
3107:
3104:
3102:
3099:
3097:
3094:
3092:
3089:
3087:
3084:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3048:
3047:
3043:
3042:
3040:
3036:
3033:
3031:
3030:Immune system
3027:
3023:
3022:immune system
3019:
3012:
3007:
3005:
3000:
2998:
2993:
2992:
2989:
2977:
2974:
2972:
2969:
2967:
2966:Tildrakizumab
2964:
2962:
2959:
2957:
2954:
2952:
2949:
2947:
2944:
2942:
2939:
2937:
2934:
2932:
2929:
2927:
2924:
2922:
2919:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2896:Pegcetacoplan
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2857:
2854:
2852:
2849:
2847:
2844:
2842:
2839:
2836:
2832:
2829:
2827:
2824:
2822:
2819:
2817:
2814:
2812:
2809:
2807:
2806:Darvadstrocel
2804:
2802:
2799:
2797:
2794:
2792:
2789:
2787:
2784:
2782:
2779:
2777:
2774:
2772:
2769:
2767:
2764:
2762:
2759:
2758:
2756:
2752:
2742:
2739:
2737:
2734:
2732:
2729:
2725:
2722:
2720:
2717:
2716:
2715:
2714:
2713:TNF inhibitor
2710:
2706:
2703:
2701:
2698:
2697:
2696:
2695:
2691:
2690:
2688:
2685:
2680:
2670:
2667:
2665:
2662:
2661:
2659:
2657:
2653:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
2583:
2580:
2578:
2575:
2573:
2570:
2568:
2565:
2563:
2560:
2558:
2555:
2553:
2550:
2548:
2545:
2544:
2542:
2538:
2531:
2527:
2526:
2522:
2521:
2516:
2513:
2511:
2508:
2506:
2503:
2502:
2501:
2500:
2496:
2495:
2490:
2487:
2486:
2485:
2484:
2480:
2476:
2473:
2472:
2471:
2470:
2466:
2462:
2459:
2457:
2454:
2453:
2452:
2451:
2447:
2443:
2440:
2438:
2435:
2433:
2430:
2429:
2428:
2427:
2423:
2419:
2416:
2415:
2414:
2411:
2410:
2405:
2402:
2400:
2397:
2396:
2395:
2394:
2390:
2386:
2383:
2382:
2381:
2380:
2379:CD147/Basigin
2376:
2372:
2369:
2368:
2367:
2366:
2362:
2358:
2355:
2354:
2353:
2352:
2348:
2344:
2341:
2339:
2336:
2335:
2334:
2333:
2329:
2325:
2322:
2320:
2317:
2316:
2315:
2314:
2310:
2306:
2303:
2301:
2298:
2296:
2293:
2290:
2286:
2283:
2281:
2278:
2277:
2276:
2275:
2271:
2267:
2264:
2263:
2262:
2261:
2257:
2253:
2250:
2249:
2248:
2247:
2243:
2239:
2236:
2234:
2231:
2229:
2226:
2225:
2224:
2223:
2219:
2215:
2212:
2210:
2207:
2205:
2202:
2200:
2199:Muromonab-CD3
2197:
2196:
2195:
2194:
2190:
2189:
2187:
2181:
2173:
2170:
2169:
2168:
2167:
2163:
2162:
2157:
2154:
2152:
2149:
2148:
2147:
2146:
2142:
2138:
2134:
2133:
2128:
2125:
2124:
2123:
2122:
2118:
2117:
2112:
2109:
2108:
2107:
2106:
2102:
2101:
2096:
2093:
2092:
2091:
2090:
2086:
2085:
2080:
2077:
2076:
2075:
2074:
2073:Interleukin 5
2070:
2069:
2064:
2061:
2059:
2056:
2054:
2053:Tildrakizumab
2051:
2049:
2046:
2044:
2041:
2039:
2036:
2034:
2031:
2029:
2026:
2024:
2021:
2019:
2016:
2014:
2011:
2009:
2006:
2004:
2001:
1999:
1996:
1994:
1991:
1989:
1986:
1984:
1981:
1979:
1976:
1974:
1971:
1969:
1966:
1964:
1961:
1959:
1956:
1955:
1954:
1953:
1949:
1948:
1943:
1940:
1938:
1935:
1933:
1930:
1928:
1925:
1923:
1920:
1918:
1915:
1914:
1913:
1912:
1908:
1907:
1902:
1899:
1898:
1897:
1896:
1892:
1891:
1889:
1887:(noncellular)
1883:
1880:
1878:
1874:
1871:
1869:
1865:
1862:
1860:Extracellular
1858:
1848:
1845:
1843:
1840:
1838:
1835:
1833:
1830:
1828:
1827:Ridaforolimus
1825:
1823:
1820:
1819:
1817:
1815:
1811:
1805:
1802:
1801:
1799:
1797:
1793:
1790:
1786:Intracellular
1784:
1772:
1769:
1768:
1767:
1766:
1762:
1760:
1757:
1755:
1752:
1750:
1747:
1746:
1744:
1742:
1738:
1732:
1729:
1727:
1724:
1723:
1718:
1715:
1713:
1710:
1708:
1705:
1703:
1700:
1699:
1698:
1697:
1693:
1689:
1685:
1684:
1682:
1679:
1673:
1669:
1661:
1658:
1657:
1656:
1655:
1651:
1650:
1645:
1644:Teriflunomide
1642:
1640:
1637:
1636:
1634:
1633:
1629:
1628:
1623:
1620:
1618:
1615:
1614:
1613:
1612:
1608:
1607:
1605:
1603:
1599:
1596:
1592:Intracellular
1590:
1585:
1581:
1577:
1570:
1565:
1563:
1558:
1556:
1551:
1550:
1547:
1536:
1532:
1528:
1524:
1520:
1516:
1513:(4): 347–57.
1512:
1508:
1501:
1498:
1493:
1489:
1485:
1481:
1477:
1473:
1470:(5): 619–25.
1469:
1465:
1458:
1455:
1450:
1446:
1442:
1438:
1434:
1430:
1427:(8): 653–61.
1426:
1422:
1414:
1411:
1406:
1402:
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1394:
1390:
1386:
1383:(2): 125–35.
1382:
1378:
1371:
1368:
1355:
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1347:
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1338:
1333:
1329:
1324:
1319:
1315:
1311:
1308:(5): 422–31.
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1279:
1276:
1271:
1267:
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1259:
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1220:
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1201:
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1175:
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1117:
1113:
1109:
1105:
1098:
1095:
1083:
1082:www.drugs.com
1079:
1073:
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1045:
1042:
1037:
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1023:
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1015:
1011:
1007:
1003:
996:
993:
988:
984:
979:
974:
970:
966:
962:
958:
954:
947:
944:
940:
936:
932:
929:
924:
921:
908:
906:
901:
895:
893:
891:
889:
885:
872:
868:
862:
859:
846:
842:
836:
834:
832:
828:
816:
812:
808:
802:
799:
794:
790:
785:
780:
776:
772:
769:(5): 422–31.
768:
764:
760:
753:
750:
743:
741:
739:
731:
729:
727:
723:
719:
715:
711:
703:
698:
696:
693:
689:
681:
676:
674:
667:
665:
663:
659:
655:
647:
645:
643:
639:
635:
631:
626:
624:
620:
616:
612:
608:
600:
598:
596:
593:It is on the
591:
589:
585:
581:
577:
573:
569:
565:
564:TNF inhibitor
561:
557:
553:
550:
546:
542:
532:
525:
519:
508:
506:
502:
469:
467:
463:
458:
454:
450:
447:
445:
443:ECHA InfoCard
439:
432:
431:ChEMBL1201833
428:
427:
425:
423:
419:
412:
408:
407:
405:
403:
399:
392:
388:
387:
385:
383:
379:
372:
371:
369:
367:
363:
356:
352:
351:
349:
347:
343:
336:
332:
331:
329:
327:
323:
318:
312: Rx-only
305:
302:
290:
287:
277:
274:
264:
263:
261:
259:
255:
250:
242:
237:
234:
233:
231:
229:
225:
222:
219:
217:
211:
205:
196:
195:
193:
191:
185:
178:
173:
164:
163:
161:
159:
155:
151:
147:
145:
141:
137:
133:
131:
127:
123:
119:
115:
111:
109:
105:
102:Clinical data
100:
97:
94:
92:
88:
85:
82:
80:
76:
72:
70:
66:
63:
59:
54:
49:
43:
38:
30:
19:
3929:Risankizumab
3914:Lebrikizumab
3894:Clazakizumab
3884:Anrukinzumab
3863:Tralokinumab
3779:Otelixizumab
3759:
3751:
3750:
3720:Tregalizumab
3705:Tislelizumab
3675:Satralizumab
3655:Rontalizumab
3650:Retifanlimab
3625:Plozalizumab
3605:Pateclizumab
3600:Pascolizumab
3595:Ozoralizumab
3545:Lampalizumab
3535:Inebilizumab
3525:Fontolizumab
3475:Camrelizumab
3470:Benralizumab
3465:Atezolizumab
3451:
3394:Clenoliximab
3295:
3279:Bertilimumab
3274:
3263:Tremelimumab
3243:
3166:Mavrilimumab
3156:Lirentelimab
3151:Lerdelimumab
3130:
3126:Fresolimumab
3066:Atorolimumab
3044:
2976:Upadacitinib
2936:Satralizumab
2921:Ritlecitinib
2916:Risankizumab
2711:
2692:
2632:Teprotumumab
2582:Inebilizumab
2577:Fontolizumab
2557:Atorolimumab
2525:T-lymphocyte
2523:
2497:
2481:
2467:
2448:
2437:Lerdelimumab
2432:Bertilimumab
2424:
2412:
2391:
2377:
2363:
2349:
2330:
2311:
2295:Pascolizumab
2280:Obinutuzumab
2272:
2258:
2244:
2228:Clenoliximab
2220:
2204:Otelixizumab
2191:
2164:
2151:Lebrikizumab
2135:
2119:
2103:
2087:
2071:
2028:Satralizumab
2018:Risankizumab
1950:
1931:
1909:
1893:
1885:Serum target
1837:Temsirolimus
1763:
1754:Pomalidomide
1749:Lenalidomide
1707:Pimecrolimus
1686:
1660:Methotrexate
1652:
1630:
1617:Azathioprine
1609:
1594:(initiation)
1510:
1506:
1500:
1467:
1463:
1457:
1424:
1420:
1413:
1380:
1376:
1370:
1358:. Retrieved
1354:the original
1349:
1340:
1305:
1301:
1291:
1278:
1253:
1249:
1239:
1227:. Retrieved
1212:
1203:
1192:
1184:the original
1174:
1162:. Retrieved
1158:the original
1148:
1111:
1107:
1097:
1085:. Retrieved
1081:
1072:
1063:10665/371090
1053:
1044:
1009:
1005:
995:
960:
956:
946:
938:
923:
911:. Retrieved
903:
875:. Retrieved
870:
861:
849:. Retrieved
844:
818:. Retrieved
810:
801:
766:
762:
752:
735:
714:methotrexate
707:
685:
682:Availability
671:
651:
627:
604:
601:Medical uses
592:
544:
540:
539:
528:
522:
258:Legal status
252:Legal status
158:License data
29:
18:Simponi Aria
4025:from market
3995:Lemalesomab
3990:Fanolesomab
3985:Besilesomab
3924:Perakizumab
3909:Mirikizumab
3899:Gevokizumab
3889:Bimekizumab
3868:Ustekinumab
3853:Secukinumab
3838:Fezakinumab
3833:Canakinumab
3828:Briakinumab
3803:Interleukin
3756:Dostarlimab
3735:Visilizumab
3730:Vedolizumab
3725:Vatelizumab
3715:Toralizumab
3710:Tocilizumab
3695:Teclistamab
3670:Samalizumab
3660:Rovelizumab
3640:Ravulizumab
3620:Pidilizumab
3615:Pexelizumab
3580:Ocrelizumab
3575:Natalizumab
3565:Mepolizumab
3555:Ligelizumab
3550:Letolizumab
3520:Etrolizumab
3510:Epratuzumab
3480:Cedelizumab
3434:Vapaliximab
3429:Teneliximab
3419:Lumiliximab
3404:Gomiliximab
3389:Basiliximab
3361:Vepalimomab
3346:Nerelimomab
3331:Gavilimomab
3326:Faralimomab
3321:Elsilimomab
3296:Combination
3289:Zanolimumab
3284:Ontamalimab
3232:Ulocuplumab
3227:Tezepelumab
3217:Sifalimumab
3197:Pamrevlumab
3176:Morolimumab
3171:Metelimumab
3141:Lanadelumab
3076:Avdoralimab
3061:Anifrolumab
2971:Tofacitinib
2911:Ravulizumab
2901:Pirfenidone
2891:Peficitinib
2791:Canakinumab
2781:Briakinumab
2771:Bimekizumab
2766:Baricitinib
2731:Aflibercept
2642:Vepalimomab
2637:Vapaliximab
2612:Rovelizumab
2602:Pexelizumab
2592:Morolimumab
2567:Cedelizumab
2552:Anifrolumab
2547:Alemtuzumab
2505:Basiliximab
2475:Tocilizumab
2461:Vedolizumab
2456:Natalizumab
2442:Metelimumab
2385:Gavilimomab
2343:Toralizumab
2338:Teneliximab
2324:Lumiliximab
2319:Gomiliximab
2305:Ublituximab
2285:Ocrelizumab
2238:Zanolimumab
2214:Visilizumab
2172:Secukinumab
2156:Ustekinumab
2127:Elsilimomab
2111:Faralimomab
2079:Mepolizumab
2063:Ustekinumab
2058:Tocilizumab
2033:Secukinumab
1983:Canakinumab
1973:Briakinumab
1968:Bimekizumab
1963:Basiliximab
1952:Interleukin
1942:Nerelimomab
1847:Zotarolimus
1788:(reception)
1759:Thalidomide
1717:Voclosporin
1702:Ciclosporin
1696:Calcineurin
1692:Cyclophilin
1639:Leflunomide
1635:inhibitors
1298:"Golimumab"
913:11 November
877:11 November
851:11 November
759:"Golimumab"
668:Development
516: g·mol
449:100.226.360
335:476181-74-5
320:Identifiers
144:MedlinePlus
117:Other names
108:Trade names
4078:Categories
3955:Lokivetmab
3948:Veterinary
3934:Spesolimab
3919:Olokizumab
3904:Ixekizumab
3848:Guselkumab
3843:Fletikumab
3823:Brazikumab
3818:Bermekimab
3789:Sutimlimab
3763:Ibalizumab
3700:Teplizumab
3680:Siplizumab
3665:Ruplizumab
3645:Reslizumab
3635:Quilizumab
3590:Omalizumab
3540:Itolizumab
3530:Frexalimab
3505:Efalizumab
3500:Eculizumab
3495:Daclizumab
3460:Aselizumab
3455:Apolizumab
3424:Priliximab
3409:Infliximab
3351:Odulimomab
3341:Maslimomab
3336:Inolimomab
3316:Afelimomab
3253:Durvalumab
3248:Ipilimumab
3237:Varlilumab
3207:Relatlimab
3202:Placulumab
3146:Lenzilumab
3121:Emapalumab
3106:Cemiplimab
3091:Brodalumab
3086:Bleselumab
3056:Adalimumab
2961:Sutimlimab
2956:Spesolimab
2941:Siltuximab
2881:Olokizumab
2871:Ixekizumab
2866:Itacitinib
2856:Guselkumab
2851:Fingolimod
2846:Filgotinib
2796:Crovalimab
2786:Brodalumab
2776:Blisibimod
2741:Rilonacept
2724:Opinercept
2719:Etanercept
2705:Belatacept
2656:Polyclonal
2617:Siplizumab
2607:Reslizumab
2597:Ofatumumab
2587:Maslimomab
2572:Emapalumab
2515:Inolimomab
2510:Daclizumab
2489:Odulimomab
2404:Ruplizumab
2399:Frexalimab
2357:Aselizumab
2252:Efalizumab
2209:Teplizumab
2105:Interferon
2095:Omalizumab
2048:Spesolimab
2038:Siltuximab
2013:Rilonacept
2008:Olokizumab
1998:Ixekizumab
1993:Guselkumab
1988:Daclizumab
1978:Brodalumab
1937:Infliximab
1922:Afelimomab
1917:Adalimumab
1901:Eculizumab
1877:Monoclonal
1868:Antibodies
1842:Umirolimus
1822:Everolimus
1771:Apremilast
1731:Gusperimus
1712:Tacrolimus
1680:inhibitors
1672:Macrolides
1654:antifolate
1229:23 October
820:22 October
744:References
722:adalimumab
505:Molar mass
391:91X1KLU43E
366:ChemSpider
326:CAS Number
4035:Phase III
4023:Withdrawn
4000:Sulesomab
3877:Humanized
3858:Sirukumab
3690:Talizumab
3515:Erlizumab
3444:Humanized
3414:Keliximab
3399:Galiximab
3258:Nivolumab
3222:Tabalumab
3212:Sarilumab
3186:Oleclumab
3181:Namilumab
3161:Lirilumab
3136:Ianalumab
3131:Golimumab
3116:Eldelumab
3111:Dupilumab
3081:Belimumab
3051:Abrilumab
2951:Sirukumab
2946:Siponimod
2931:Sarilumab
2906:Ponesimod
2876:Netakimab
2861:Iptacopan
2841:Etrasimod
2801:Danicopan
2736:Alefacept
2700:Abatacept
2622:Talizumab
2562:Begelomab
2418:Belimumab
2371:Galiximab
2300:Rituximab
2266:Erlizumab
2233:Keliximab
2043:Sirukumab
2023:Sarilumab
2003:Netakimab
1932:Golimumab
1832:Sirolimus
1405:195685167
541:Golimumab
214:Routes of
188:Pregnancy
177:Golimumab
136:Monograph
130:Drugs.com
34:Golimumab
4068:Medicine
3376:Chimeric
3268:Urelumab
3191:Oxelumab
3101:Carlumab
3071:Avelumab
3020:for the
2886:Ozanimod
2761:Avacopan
2754:Unsorted
2540:Unsorted
2450:Integrin
2183:Cellular
1958:Anakinra
1804:Anakinra
1726:Abetimus
1578: /
1527:23568177
1507:BioDrugs
1492:21538173
1484:21506984
1449:23085023
1441:23576019
1397:19489653
1377:BioDrugs
1332:20065639
1270:25887212
1164:28 April
1140:24648749
1114:: 53–9.
1052:(2023).
1036:24161836
987:24161836
931:Archived
871:DailyMed
845:DailyMed
793:20065639
699:Research
692:Centocor
531:(verify)
346:DrugBank
228:ATC code
190:category
172:DailyMed
120:CNTO-148
3970:lesions
3745:TGN1412
3630:PRO 140
2682:-cept (
1323:2759491
1131:3958527
1027:4079096
978:4079096
784:2759491
732:Uveitis
580:(MMP)-3
547:, is a
545:Simponi
466:Formula
355:DB06674
303:Rx-only
300:WARNING
244:)
238: (
236:L04AB06
203: C
174::
150:a610010
4054:Portal
4018:WHO-EM
3760:Other:
2694:CTLA-4
2684:Fusion
2185:target
2166:IL-17A
2143:, and
1676:other
1535:391892
1533:
1525:
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781:
660:, and
582:, and
576:ICAM)-
572:(IL)-6
422:ChEMBL
411:D04358
297:
284:
271:
170:
91:Target
79:Source
3978:Mouse
3811:Human
3309:Mouse
3275:Other
3038:Human
2483:LFA-1
2393:CD154
2246:CD11a
2145:IL-23
2141:IL-13
2137:IL-12
1741:IMiDs
1531:S2CID
1488:S2CID
1445:S2CID
1401:S2CID
1360:9 May
1087:9 May
907:(EMA)
549:human
480:10068
84:Human
2413:BLyS
2365:CD80
2332:CD40
2313:CD23
2274:CD20
2260:CD18
2121:IL-6
1814:mTOR
1688:FKBP
1678:IL-2
1523:PMID
1480:PMID
1437:PMID
1393:PMID
1362:2016
1328:PMID
1302:mAbs
1266:PMID
1231:2010
1166:2008
1136:PMID
1089:2016
1032:PMID
983:PMID
915:2020
879:2020
853:2020
822:2023
789:PMID
763:mAbs
724:and
640:and
617:and
605:The
492:2026
486:1752
474:6530
402:KEGG
382:UNII
373:none
126:AHFS
96:TNFα
69:Type
53:5yoy
2426:CAT
2222:CD4
2193:CD3
1911:TNF
1584:L04
1515:doi
1472:doi
1429:doi
1385:doi
1318:PMC
1310:doi
1258:doi
1126:PMC
1116:doi
1058:hdl
1022:PMC
1014:doi
973:PMC
965:doi
815:FDA
779:PMC
771:doi
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