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Males are twice as likely as females to have this characteristic, and it tends to run in families. In its non-symptomatic form, it is more common among Asians and Native
Americans than among other populations, and in some families there is a tendency to inherit the condition unilaterally; that is, on
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The presence of a single transverse palmar crease has no medical significance. It is found in 1.5% of all people, and though it is found at a higher frequency in people with abnormal medical conditions, in every one of these conditions many people do not have a single transverse palmar crease, thus
428:
Marquardt, Thorsten; Brune, Thomas; Lühn, Kerstin; Zimmer, Klaus-Peter; Körner, Christian; Fabritz, Larissa; Van Der Werft, Natascha; Vormoor, Josef; Freeze, Hudson H.; Louwen, Frank; Biermann, Bettina; Harms, Eric; von Figura, Kurt; Vestweber, Dietmar; Koch, Hans Georg (30 June 1999).
478:
Olivieri, C.; Maraschio, P.; Caselli, D.; Martini, C.; Beluffi, G.; Maserati, E.; Danesino, C. (February 2003). "Interstitial deletion of chromosome 9, int del(9)(9q22.31-q31.2), including the genes causing multiple basal cell nevus syndrome and
Robinow/brachydactyly 1 syndrome".
77:. Although it is found more frequently in persons with several abnormal medical conditions, it is not predictive of any of these conditions since it is also found in persons with no abnormal medical conditions. It is found in 1.5% of the world population in at least one hand.
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The presence of a single transverse palmar has been associated with a number of abnormal medical conditions—that is, it is found at a higher than 1.5% frequency, but in all of these conditions many do not have this crease. Examples of conditions with such an association are
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A 1971 study refutes the hypothesis that the phenomenon is caused by fetal hand movement: the appearance of the crease occurs around the second month of gestation, before the digital movement phase in the womb begins.
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While it is often found in people with Down
Syndrome, many who have this syndrome do not have this crease, and thus is not a diagnostic indicator of the Down Syndrome.
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Bilateral single transverse palmar crease. The single transverse palmar crease is present on both hands of the individual.
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Hammer, Stephen J. McPhee, Gary D. (2010). "Pathophysiology of
Selected Genetic Diseases".
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431:"Leukocyte adhesion deficiency II syndrome, a generalized defect in fucose metabolism"
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97:. These terms have widely fallen out of favor due to their pejorative connotation.
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Bali, R. S.; Chaube, Ramesh (July 1971). "On the
Formulation of Palmar Creases".
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197:. It is also sometimes found on the hand of the affected side of patients with
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Preventive management of children with congenital anomalies and syndromes
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Pathophysiology of disease : an introduction to clinical medicine
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393:(6th ed.). New York: McGraw-Hill Medical. pp. Chapter 2.
185:. A unilateral single palmar crease was also reported in a case of
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181:(X-linked recessive), or autosomal recessive disorder, such as
277:"Palmar Crease Variants and Their Clinical Significance"
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is a single crease that extends across the palm of the
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Because it resembles the usual condition of non-human
316:. Cambridge, UK: Cambridge University Press. p.
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Single transverse palmar crease on an infant's hand
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121:, and with the genetic chromosomal abnormalities
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221:Single transverse palmar crease in an adult
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351:United States National Library of Medicine
288:United States National Library of Medicine
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372:. MedicineNet, Inc. 2005. Archived from
308:Cooley, W. Carl; Wilson, Golder (2000).
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341:McPherson M.D., Katrina (3 May 2004).
183:leukocyte adhesion deficiency-2 (LAD2)
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233:More common palmar creases in adults
191:nevoid basal cell carcinoma syndrome
275:Dar M.D., Hannah (6 August 1976).
89:, it was, in the past, called the
73:, formed by the fusion of the two
16:Crease across the palm of the hand
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67:single transverse palmar crease
25:Single transverse palmar crease
481:European Journal of Pediatrics
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447:10.1016/S0022-3476(99)70281-7
366:"Definition of Simian crease"
106:it has low predictive value.
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33:Simian crease, simian line
493:10.1007/s00431-002-1116-4
435:The Journal of Pediatrics
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143:Wolf–Hirschhorn syndrome
536:10.1127/zma/63/1971/121
179:Aarskog–Scott syndrome
119:fetal alcohol syndrome
347:Medical Encyclopedia
284:Medical Encyclopedia
139:Klinefelter syndrome
131:cri du chat syndrome
101:Medical significance
616:External resources
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327:978-0-521-77673-8
189:mutation causing
171:Edward's syndrome
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19:Medical condition
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147:Noonan syndrome
110:one hand only.
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155:Patau syndrome
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378:. Retrieved
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187:chromosome 9
135:chromosome 5
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625:MedlinePlus
370:MedicineNet
95:simian line
81:Former name
30:Other names
648:Categories
293:20 October
263:References
409:cite book
53:Specialty
607:757.200)
560:36961365
544:25755944
509:10565922
501:12548386
465:10356134
251:See also
605:CDC/BPA
552:5105808
456:7095022
177:), and
87:simians
630:003290
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201:, and
601:757.2
556:S2CID
540:JSTOR
505:S2CID
280:(PDF)
654:Hand
596:9-CM
548:PMID
497:PMID
461:PMID
415:link
395:ISBN
382:2006
358:2006
322:ISBN
295:2016
193:and
71:hand
592:ICD
532:doi
489:doi
485:162
451:PMC
443:doi
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
