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Michael Berridge

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Surprisingly, he found that serotonin and cyclic AMP produced opposite effect to ion movement. While the former reduced the transepithelial potential difference closer to zero, the latter caused an even more negative difference. This suggested cyclic AMP caused positively-charged ions to move across
2423: 491:. He first joined as a senior scientific officer, and was promoted to principal scientific officer in 1972. He became a senior principal scientific officer at the Unit of Insect Neurophysiology and Pharmacology, also at the University of Cambridge, in 1978. 498:
as the Deputy Chief Scientific Officer of the Laboratory of Molecular Signalling, before serving as the Head of Signalling in 1996 until retiring in 2003. After retirement, Berridge was appointed as Babraham's first emeritus Babraham Fellow.
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activation and the release of intracellular Ca from storage. He was inspired by a review article by Robert H. Michell in 1975, which proposed receptor activation caused the breakdown of
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secretion. The idea of second messenger was new at the time, and his finding supported cyclic AMP as a second messenger of serotonin.
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at Cambridge. He and Rasmussen worked together and found serotonin triggered the release of Ca from a storage inside the
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Honorary foreign member of the Royal Academy of Medicine of Belgium (Académie royale de médecine de Belgique) (1991)
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and join the new Unit of Invertebrate Chemistry and Physiology that he was setting up in the Department of
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The physiology of excretion in the cotton stainer, Dysdercus fasciatus Signoret (Hemiptera, Pyrrhocoridae)
211: 138: 108: 4240: 3973: 1589: 1533: 3629: 3146: 829: 692: 634: 469: 457: 1473:"Role of Calcium and Adenosine-3′:5′-Cyclic Monophosphate in Controlling Fly Salivary Gland Secretion" 4279: 4274: 4050: 3937: 3165: 2722: 2624: 2584: 2578: 2535: 1771: 1706: 1486: 1363: 883: 856: 638: 433: 413: 401: 253: 121: 4139: 3913: 3949: 3818: 3651: 3508: 3446: 3219: 3116: 2904: 2853: 2679: 2397: 2251: 1963: 1646: 1271: 981: 947: 894: 801: 797: 604: 518: 367: 112: 1245: 3996: 3723: 3518: 3245: 3215: 3068: 3010: 2831: 2752: 2673: 2574: 2521: 2226: 1844: 1795: 1755: 1730: 1563: 1387: 1212: 923: 696: 677: 654: 615: 495: 465: 437: 355: 316: 223: 117: 4174: 3486: 3321: 2082:. Royal Academy of Medicine of Belgium (Académie royale de médecine de Belgique). Archived from 1052: 2221: 4246: 4186: 4109: 4103: 3967: 3836: 3641: 3623: 3538: 3384: 3249: 3231: 3122: 3054: 3028: 2894: 2888: 2756: 2728: 2610: 2598: 2588: 2560: 2543: 1993: 1903: 1836: 1787: 1722: 1673: 1611: 1555: 1514: 1437: 1379: 1354: 1323: 1182: 1118: 760: 735: 708: 425: 382: 340: 152: 85: 1113: 1094: 4127: 3824: 3812: 3782: 3502: 3452: 3406: 3309: 3263: 3235: 3195: 3140: 3126: 2847: 2837: 2827: 1828: 1779: 1714: 1697: 1663: 1655: 1603: 1547: 1504: 1494: 1468: 1427: 1371: 1315: 1147: 1108: 1064: 704: 619: 348: 336: 332: 248: 81: 1349: 622:, one of the first researchers to recognise the role of Ca as a second messenger, was on a 575:, and conducted experiments to study how serotonin and cyclic AMP affected the movement of 4228: 4204: 4133: 4080: 4044: 4032: 4026: 3943: 3919: 3907: 3866: 3860: 3741: 3717: 3591: 3532: 3496: 3430: 3426: 3416: 3361: 3259: 3255: 3209: 3106: 3100: 3094: 3062: 3034: 2998: 2992: 2978: 2874: 2809: 2803: 2797: 2793: 2736: 2634: 2475: 2169: 2139: 1877: 1275: 825: 807: 778: 642: 608: 596: 510: 312: 176: 160: 1301: 669:
to blow fly salivary glands to inhibit the conversion of inositol phosphate to inositol.
1775: 1710: 1490: 1367: 1186: 4062: 3925: 3883: 3800: 3788: 3770: 3747: 3729: 3699: 3647: 3617: 3605: 3542: 3474: 3464: 3420: 3365: 3351: 3341: 3325: 3299: 3279: 3269: 3136: 3132: 3112: 3048: 2968: 2841: 2746: 2732: 2657: 2651: 2604: 2539: 1760:"The role of protein kinase C in cell surface signal transduction and tumour promotion" 1668: 1641: 627: 549: 530: 514: 397: 320: 300: 263: 132: 2371: 1509: 1472: 4268: 4210: 4180: 4074: 4068: 4008: 3961: 3889: 3794: 3711: 3693: 3512: 3490: 3480: 3470: 3436: 3396: 3239: 3169: 3074: 3044: 3018: 2986: 2817: 2718: 2663: 2620: 2109: 2057: 1997: 1967: 1873: 1607: 1551: 977:"Sir Michael Berridge, biochemist behind a paradigm shift in cell science – obituary" 725: 646: 553: 480: 441: 31: 1567: 1391: 17: 4222: 4192: 4168: 4156: 3848: 3842: 3830: 3776: 3735: 3663: 3611: 3548: 3522: 3458: 3390: 3335: 3273: 3225: 3177: 3173: 3082: 2972: 2900: 2884: 2823: 2787: 2770: 2766: 2691: 2685: 2614: 2529: 2525: 2199: 2023: 1848: 1799: 1734: 819: 404:, regarded as the father of insect physiology, at the Department of Zoology of the 292: 201: 1375: 4252: 4198: 3931: 3901: 3806: 3705: 3657: 3355: 3329: 3315: 3303: 3293: 3289: 3088: 2962: 2880: 2813: 2701: 2630: 791: 658: 172: 1478:
Proceedings of the National Academy of Sciences of the United States of America
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near Cambridge, Berridge found that phosphatidylinositol was hydrolysed into
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to allowing Ca influx into cells. He hypothesised phosphatidylinositol was
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Berridge, Michael J.; Bootman, Martin D.; Roderick, H. Llewelyn (2003).
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released Ca from the intracellular storage, which he identified as the
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Recipients of the Albert Lasker Award for Basic Medical Research
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Streb, H.; Irvine, R. F.; Berridge, M. J.; Schulz, I. (1983).
1640:; Downes, C. Peter; Heslop, John P.; Irvine, Robin F. (1983). 576: 548:, who had also worked at Case Western Reserve. Working on the 1595:
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes
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was named in his honour and established with his endowment.
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teacher convinced him and his parents that he should pursue
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Fellows of the Academy of Medical Sciences (United Kingdom)
1815:"Calcium signalling: dynamics, homeostasis and remodelling" 1590:"Inositol phospholipids and cell surface receptor function" 595:
in electric potential across the epithelium since ions are
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of the University of Cambridge from 1972 until his death.
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Berridge then wanted to identify the connection between
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He continued studying cyclic AMP after returning to the
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Dr H. P. Heineken Prize for Biochemistry and Biophysics
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Dr H. P. Heineken Prize for Biochemistry and Biophysics
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Members of the European Molecular Biology Organization
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Foreign associates of the National Academy of Sciences
661:(DAG), and the former was eventually broken down into 556:
species, Berridge showed cyclic AMP produced the same
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Fellows of the American Academy of Arts and Sciences
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Biographical Memoirs of Fellows of the Royal Society
412:, where Wigglesworth was a fellow, and obtained his 4149: 4090: 3983: 3876: 3763: 3598: 3375: 3156: 2955: 2863: 2780: 2711: 2644: 2553: 2514: 291:(22 October 1938 - 13 February 2020) was a British 259: 247: 229: 207: 193: 148: 128: 104: 92: 63: 41: 607:to the inside of the salivary gland (known as the 2020:"1989 Albert Lasker Basic Medical Research Award" 1412:Berridge, Michael J.; Prince, William T. (1972). 4285:Alumni of Gonville and Caius College, Cambridge 1242:"The Prize in Life Science & Medicine 2005" 2230:(1st supplement). 30 December 1997. p. 1. 773:Albert Lasker Award for Basic Medical Research 169:Albert Lasker Award for Basic Medical Research 4395:Members of the American Philosophical Society 3576: 2932: 2491: 687:and DAG. Later the same year, he confirmed IP 8: 1295: 1293: 109:University College of Rhodesia and Nyasaland 971: 969: 3583: 3569: 3561: 2939: 2925: 2917: 2498: 2484: 2476: 1467:Prince, William T.; Berridge, Michael J.; 1010: 1008: 1006: 1004: 736:King Faisal International Prize in Science 509:Berridge maintained an online textbook on 153:King Faisal International Prize in Science 38: 4350:Rhodesian emigrants to the United Kingdom 2196:"Massry Prize Winners ( 1996 – Present )" 1667: 1508: 1498: 1431: 1134: 1132: 1112: 1095:"Unlocking the secrets of cell signaling" 1088: 1086: 1084: 1082: 1080: 1068: 1114:10.1146/annurev.physiol.67.040103.152647 30:For the New Zealand cell biologist, see 4330:Fellows of the Royal Society of Biology 2054:European Molecular Biology Organization 935: 901:Shaw Prize in Life Science and Medicine 798:Ciba-Drew Award for Biomedical Research 783:European Molecular Biology Organization 181:Shaw Prize in Life Science and Medicine 1348:Berridge, M. J.; Patel, N. G. (1968). 1236: 1234: 1209:"In tribute: Sir Michael Berridge FRS" 1173: 1171: 1169: 1167: 1165: 922:The Sir Michael Berridge Prize at the 436:, Berridge's plan was thwarted by the 4315:Fellows of Trinity College, Cambridge 2368:American Academy of Arts and Sciences 1820:Nature Reviews Molecular Cell Biology 874:American Academy of Arts and Sciences 872:International Honorary Member of the 7: 2456:. Babraham Institute. Archived from 1539:Molecular and Cellular Endocrinology 703:in its own right and could activate 360:University of Rhodesia and Nyasaland 4355:Rhodesian people of British descent 1140:"Autobiography of Michael Berridge" 754:Canada Gairdner International Award 707:, marked the start of the field of 676:, who was studying inositol at the 444:instead, joining the Department of 358:, and he entered the newly founded 303:, in particular the discovery that 165:Canada Gairdner International Award 27:British physiologist and biochemist 2274:"Sir Michael Berridge FRS FMedSci" 2172:. 10 December 2018. Archived from 2106:"Award winners : Royal Medal" 1215:. 13 February 2020. Archived from 1025:. 21 November 2017. Archived from 985:. 23 February 2020. Archived from 483:invited Berridge to return to the 408:. Berridge became a member at the 25: 424:Initially intending to return to 4380:Wolf Prize in Medicine laureates 2454:"The Sir Michael Berridge Prize" 1532:Berridge, Michael John. (1981). 742:Louis-Jeantet Prize for Medicine 476:of the same university in 1967. 456:. A year later, he moved to the 157:Louis-Jeantet Prize for Medicine 1900:"Professor Michael J. Berridge" 1419:Journal of Experimental Biology 1016:"Prof. Dr. Michael J. Berridge" 915:British Pharmacological Society 535:Case Western Reserve University 462:Case Western Reserve University 299:. He was known for his work on 216:Case Western Reserve University 2428:American Philosophical Society 1936:. October 2017. Archived from 1302:"Interview with Mike Berridge" 908:American Philosophical Society 587:across the epithelium through 1: 4375:Winners of the Heineken Prize 4365:University of Zimbabwe alumni 2370:. 31 May 2023. Archived from 2247:Cambridge University Reporter 1093:Berridge, Michael J. (2005). 695:. This report, together with 502:Berridge was a fellow of the 494:In 1990, Berridge joined the 4385:Members of Academia Europaea 4340:People from Kadoma, Zimbabwe 4310:Fellows of the Royal Society 2338:National Academy of Sciences 2242:"Gonville and Caius College" 1930:"Professor Michael BERRIDGE" 1608:10.1016/0304-4157(75)90017-9 1552:10.1016/0303-7207(81)90119-2 1376:10.1126/science.162.3852.462 1244:. Shaw Prize. Archived from 867:National Academy of Sciences 699:'s discovery that DAG was a 3599:Biochemistry and Biophysics 2278:Academy of Medical Sciences 1588:Robert H., Michell (1975). 1179:"Sir Michael John Berridge" 1100:Annual Review of Physiology 851:Academy of Medical Sciences 583:controlled the movement of 529:Berridge had been studying 4411: 837:Gonville and Caius College 674:Rex Malcolm Chaplin Dawson 564:, dramatically increasing 546:Earl Wilbur Sutherland Jr. 410:Gonville and Caius College 29: 2424:"Sir Michael J. Berridge" 2308:Ernst Schering Foundation 2136:"Sir Michael J. Berridge" 1268:"Cell Signalling Biology" 1051:Petersen, Ole H. (2024). 1023:Ernst Schering Foundation 276:Sir Michael John Berridge 269: 186: 1934:Louis-Jeantet Foundation 888:Royal Society of Biology 748:William Bate Hardy Prize 603:the epithelium from the 591:. Berridge measured the 381:He became interested in 327:Early life and education 311:, linking events at the 4335:Massry Prize recipients 3443:Demetrios Christodoulou 3284:Everett Peter Greenberg 2364:"Michael John Berridge" 1300:Berridge, Mike (2005). 913:Honorary Fellow of the 893:Honorary Member of the 841:University of Cambridge 835:Honorary Fellow of the 641:, which in turn opened 573:University of Cambridge 485:University of Cambridge 406:University of Cambridge 385:after helping with his 220:University of Cambridge 4370:White Rhodesian people 3896:BirdLife International 3877:Environmental Sciences 2885:Lynne Elizabeth Maquat 2871:Emmanuelle Charpentier 2508:Wolf Prize in Medicine 1990:"Sir Michael Berridge" 1636:Berridge, Michael J.; 1070:10.1098/rsbm.2023.0047 814:Wolf Prize in Medicine 450:University of Virginia 364:University of Zimbabwe 305:inositol trisphosphate 212:University of Virginia 139:inositol trisphosphate 4295:British physiologists 3147:Shrinivas R. Kulkarni 2334:"Michael J. Berridge" 2304:"Michael J. Berridge" 2166:"Michael J. Berridge" 2050:"Michael J. Berridge" 1960:"Michael J. Berridge" 1500:10.1073/pnas.69.3.553 693:endoplasmic reticulum 635:cell surface receptor 472:at the Department of 470:Bodil Schmidt-Nielsen 458:Developmental Biology 440:. He migrated to the 331:Berridge was born in 68:Michael John Berridge 3206:Keith H. S. Campbell 3166:Stanley Norman Cohen 2723:Alexander Varshavsky 2625:Elizabeth F. Neufeld 2585:Jean-Pierre Changeux 2579:Stanley Norman Cohen 1433:10.1242/jeb.56.1.139 884:Institute of Biology 863:International Member 857:Ernst Schering Prize 639:phosphatidylinositol 402:Vincent Wigglesworth 315:with the release of 254:Vincent Wigglesworth 43:Sir Michael Berridge 18:Sir Michael Berridge 4360:Royal Medal winners 4290:British biochemists 3509:Alexander Beilinson 3447:Richard S. Hamilton 3117:Chryssa Kouveliotou 2854:Jeffrey M. Friedman 2680:Stanley B. Prusiner 2460:on 11 November 2023 2404:on 20 November 2023 2398:Biochemical Society 2374:on 20 November 2023 2344:on 20 November 2023 2314:on 14 November 2023 2284:on 20 November 2023 2254:on 14 November 2023 2202:on 14 November 2023 2176:on 14 November 2023 2146:on 14 November 2023 2116:on 20 November 2023 2060:on 17 November 2023 2000:on 17 November 2023 1970:on 14 November 2023 1964:Gairdner Foundation 1940:on 14 November 2023 1910:on 14 November 2023 1880:on 17 November 2023 1776:1984Natur.308..693N 1756:Nishizuka, Yasutomi 1711:1983Natur.306...67S 1647:Biochemical Journal 1491:1972PNAS...69..553P 1448:on 28 November 2023 1368:1968Sci...162..462B 1278:on 19 December 2023 1272:Biochemical Society 1248:on 11 November 2023 1219:on 11 November 2023 989:on 27 February 2020 948:New College, Oxford 895:Biochemical Society 802:Novartis-Drew Award 614:Berridge suspected 605:extracellular fluid 519:Biochemical Society 454:postdoctoral fellow 3519:Jean-Michel Bismut 3246:Franz-Ulrich Hartl 3069:William J. Borucki 2832:Jeffrey V. Ravetch 2753:Alexander Levitzki 2674:Yasutomi Nishizuka 2575:Barbara McClintock 2434:on 2 November 2023 2394:"Honorary Members" 2227:The London Gazette 2086:on 29 January 2023 2080:"BERRIDGE Michael" 2030:on 2 November 2023 1870:"Michael Berridge" 1320:10.1002/bies.20186 1213:Babraham Institute 1189:on 8 November 2023 1150:on 7 November 2023 1032:on 3 November 2023 954:on 6 November 2023 924:Babraham Institute 715:Awards and honours 697:Yasutomi Nishizuka 678:Babraham Institute 655:inositol phosphate 496:Babraham Institute 466:research associate 438:Rhodesian Bush War 396:, and went to the 356:tertiary education 224:Babraham Institute 118:University College 4262: 4261: 4091:Cognitive Science 3558: 3557: 3539:Vladimir Drinfeld 3385:Shiing-Shen Chern 3342:Paul A. Negulescu 3250:Arthur L. Horwich 3123:Lennart Lindegren 3055:Daniel Eisenstein 2914: 2913: 2895:Daniel J. Drucker 2757:Anthony R. Hunter 2729:Ralph L. Brinster 2611:Pedro Cuatrecasas 2599:Donald F. Steiner 2589:Solomon H. Snyder 2544:Oleh Hornykiewicz 2506:Laureates of the 1994:Academia Europaea 1904:King Faisal Prize 1770:(5961): 693–698. 1660:10.1042/bj2120473 1638:Dawson, Rex M. C. 1469:Rasmussen, Howard 1362:(3852): 462–463. 1183:Academia Europaea 761:Academia Europaea 709:calcium signaling 426:Southern Rhodesia 383:insect physiology 341:Southern Rhodesia 273: 272: 188:Scientific career 86:Southern Rhodesia 16:(Redirected from 4402: 4325:Knights Bachelor 3956:Sinninghe DamstĂ© 3585: 3578: 3571: 3562: 3503:Michel Talagrand 3453:Maxim Kontsevich 3407:Robert Langlands 3346:Michael J. Welsh 3310:Mary-Claire King 3264:Michael W. Young 3236:Ruslan Medzhitov 3220:Jeffrey Friedman 3196:Robert Lefkowitz 3184:Michael Berridge 3141:Maura McLaughlin 3127:Michael Perryman 2941: 2934: 2927: 2918: 2905:JosĂ©-Alain Sahel 2848:James P. Allison 2838:Lewis C. Cantley 2828:Philippa Marrack 2670:Michael Berridge 2500: 2493: 2486: 2477: 2470: 2469: 2467: 2465: 2450: 2444: 2443: 2441: 2439: 2430:. 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Archived from 944:"Antony Galione" 940: 705:protein kinase C 701:second messenger 620:Howard Rasmussen 539:second messenger 513:, now hosted by 337:Kadoma, Zimbabwe 319:(Ca) within the 309:second messenger 290: 260:Notable students 249:Doctoral advisor 243: 143:second messenger 99: 96:13 February 2020 77: 75: 58: 39: 21: 4410: 4409: 4405: 4404: 4403: 4401: 4400: 4399: 4265: 4264: 4263: 4258: 4145: 4086: 3979: 3872: 3759: 3594: 3592:Heineken Prizes 3589: 3559: 3554: 3533:Ehud Hrushovski 3497:Luis Caffarelli 3431:Clifford Taubes 3427:Simon Donaldson 3417:Vladimir Arnold 3377: 3371: 3362:Stuart H. Orkin 3322:Gero Miesenböck 3260:Michael Rosbash 3256:Jeffrey C. Hall 3216:Douglas Coleman 3210:Shinya Yamanaka 3158: 3152: 3107:Roger Blandford 3101:Edward C. Stone 3095:Jean-Loup Puget 3063:John A. Peacock 3035:David C. Jewitt 3011:Charles Bennett 2999:Reinhard Genzel 2993:Peter Goldreich 2979:Saul Perlmutter 2951: 2945: 2915: 2910: 2875:Jennifer Doudna 2859: 2810:Nahum Sonenberg 2804:Ronald M. Evans 2798:Rudolf Jaenisch 2794:Shinya Yamanaka 2776: 2743:Robert Weinberg 2737:Oliver Smithies 2707: 2640: 2635:Edward B. Lewis 2569:James L. Gowans 2549: 2530:Jon J. van Rood 2510: 2504: 2474: 2473: 2463: 2461: 2452: 2451: 2447: 2437: 2435: 2422: 2421: 2417: 2407: 2405: 2392: 2391: 2387: 2377: 2375: 2362: 2361: 2357: 2347: 2345: 2332: 2331: 2327: 2317: 2315: 2302: 2301: 2297: 2287: 2285: 2272: 2271: 2267: 2257: 2255: 2240: 2239: 2235: 2220: 2219: 2215: 2205: 2203: 2194: 2193: 2189: 2179: 2177: 2170:Wolf Foundation 2164: 2163: 2159: 2149: 2147: 2140:Heineken Prizes 2134: 2133: 2129: 2119: 2117: 2104: 2103: 2099: 2089: 2087: 2078: 2077: 2073: 2063: 2061: 2048: 2047: 2043: 2033: 2031: 2018: 2017: 2013: 2003: 2001: 1988: 1987: 1983: 1973: 1971: 1958: 1957: 1953: 1943: 1941: 1928: 1927: 1923: 1913: 1911: 1898: 1897: 1893: 1883: 1881: 1868: 1867: 1863: 1853: 1851: 1833:10.1038/nrm1155 1812: 1811: 1807: 1754: 1753: 1749: 1739: 1737: 1705:(5938): 67–69. 1690: 1689: 1685: 1635: 1634: 1630: 1620: 1618: 1587: 1586: 1582: 1572: 1570: 1531: 1530: 1526: 1466: 1465: 1461: 1451: 1449: 1411: 1410: 1406: 1396: 1394: 1347: 1346: 1342: 1332: 1330: 1299: 1298: 1291: 1281: 1279: 1266: 1265: 1261: 1251: 1249: 1240: 1239: 1232: 1222: 1220: 1207: 1206: 1202: 1192: 1190: 1177: 1176: 1163: 1153: 1151: 1138: 1137: 1130: 1092: 1091: 1078: 1050: 1049: 1045: 1035: 1033: 1029: 1018: 1014: 1013: 1002: 992: 990: 975: 974: 967: 957: 955: 942: 941: 937: 932: 920: 880:Honorary Fellow 826:Knight Bachelor 717: 690: 685: 672:With help from 653:into a form of 550:salivary glands 533:when he was at 527: 511:cell signalling 504:Trinity College 422: 392:'s research on 366:), earning his 329: 313:plasma membrane 278: 241: 222: 218: 214: 200: 179: 175: 171: 167: 163: 161:Knight Bachelor 159: 155: 136: 116: 97: 88: 84: 79: 78:22 October 1938 73: 71: 70: 69: 59: 46: 44: 35: 28: 23: 22: 15: 12: 11: 5: 4408: 4406: 4398: 4397: 4392: 4387: 4382: 4377: 4372: 4367: 4362: 4357: 4352: 4347: 4342: 4337: 4332: 4327: 4322: 4317: 4312: 4307: 4302: 4297: 4292: 4287: 4282: 4277: 4267: 4266: 4260: 4259: 4257: 4256: 4250: 4244: 4238: 4235:Van Oldenborgh 4232: 4226: 4220: 4214: 4208: 4202: 4196: 4190: 4184: 4178: 4172: 4166: 4160: 4153: 4151: 4147: 4146: 4144: 4143: 4137: 4131: 4125: 4119: 4113: 4107: 4101: 4094: 4092: 4088: 4087: 4085: 4084: 4078: 4072: 4066: 4060: 4054: 4048: 4042: 4036: 4030: 4024: 4018: 4012: 4006: 4000: 3994: 3987: 3985: 3981: 3980: 3978: 3977: 3971: 3965: 3959: 3953: 3947: 3941: 3935: 3929: 3923: 3917: 3911: 3905: 3899: 3893: 3887: 3880: 3878: 3874: 3873: 3871: 3870: 3864: 3858: 3852: 3846: 3840: 3834: 3828: 3822: 3816: 3810: 3804: 3798: 3792: 3786: 3780: 3774: 3767: 3765: 3761: 3760: 3758: 3757: 3751: 3745: 3739: 3733: 3727: 3721: 3715: 3709: 3703: 3697: 3691: 3685: 3679: 3673: 3667: 3661: 3655: 3645: 3639: 3633: 3627: 3621: 3615: 3609: 3602: 3600: 3596: 3595: 3590: 3588: 3587: 3580: 3573: 3565: 3556: 3555: 3553: 3552: 3546: 3543:Shing-Tung Yau 3536: 3526: 3516: 3506: 3500: 3494: 3484: 3478: 3475:Henryk Iwaniec 3468: 3465:George Lusztig 3462: 3456: 3450: 3440: 3434: 3424: 3421:Ludwig Faddeev 3414: 3411:Richard Taylor 3404: 3394: 3388: 3381: 3379: 3373: 3372: 3370: 3369: 3366:Swee Lay Thein 3359: 3352:Patrick Cramer 3349: 3339: 3333: 3326:Peter Hegemann 3319: 3313: 3307: 3300:Ian R. Gibbons 3297: 3287: 3280:Bonnie Bassler 3277: 3270:Kazutoshi Mori 3267: 3253: 3243: 3232:Jules Hoffmann 3229: 3223: 3213: 3199: 3193: 3187: 3181: 3162: 3160: 3154: 3153: 3151: 3150: 3144: 3137:Duncan Lorimer 3133:Matthew Bailes 3130: 3120: 3113:Victoria Kaspi 3110: 3104: 3098: 3092: 3086: 3072: 3066: 3052: 3049:John F. Hawley 3042: 3032: 3029:Gerald Fishman 3022: 3008: 3002: 2996: 2990: 2976: 2969:Geoffrey Marcy 2966: 2959: 2957: 2953: 2952: 2946: 2944: 2943: 2936: 2929: 2921: 2912: 2911: 2909: 2908: 2898: 2892: 2889:Adrian Krainer 2878: 2867: 2865: 2861: 2860: 2858: 2857: 2851: 2845: 2842:C. Ronald Kahn 2835: 2821: 2807: 2801: 2791: 2784: 2782: 2778: 2777: 2775: 2774: 2764: 2750: 2747:Roger Y. Tsien 2740: 2733:Mario Capecchi 2726: 2715: 2713: 2709: 2708: 2706: 2705: 2699: 2689: 2683: 2677: 2667: 2661: 2658:Seymour Benzer 2655: 2652:Maclyn McCarty 2648: 2646: 2642: 2641: 2639: 2638: 2628: 2618: 2608: 2605:Osamu Hayaishi 2602: 2596: 2593:James W. Black 2582: 2572: 2561:CĂ©sar Milstein 2557: 2555: 2551: 2550: 2548: 2547: 2540:Arvid Carlsson 2533: 2518: 2516: 2512: 2511: 2505: 2503: 2502: 2495: 2488: 2480: 2472: 2471: 2445: 2415: 2385: 2355: 2325: 2295: 2265: 2233: 2213: 2187: 2157: 2127: 2097: 2071: 2041: 2011: 1981: 1951: 1921: 1891: 1861: 1827:(7): 517–529. 1805: 1747: 1683: 1654:(2): 473–482. 1628: 1580: 1524: 1485:(3): 553–557. 1459: 1426:(1): 139–153. 1404: 1340: 1314:(2): 201–210. 1289: 1259: 1230: 1200: 1161: 1128: 1076: 1043: 1000: 965: 934: 933: 931: 928: 919: 918: 911: 906:Member of the 904: 898: 891: 877: 870: 860: 854: 844: 833: 823: 817: 811: 805: 795: 789: 786: 776: 770: 764: 759:Member of the 757: 751: 745: 739: 733: 718: 716: 713: 688: 683: 531:cell signaling 526: 523: 515:Portland Press 464:. He became a 421: 418: 400:to study with 398:United Kingdom 328: 325: 301:cell signaling 271: 270: 267: 266: 264:Antony Galione 261: 257: 256: 251: 245: 244: 233: 227: 226: 209: 205: 204: 195: 191: 190: 184: 183: 150: 146: 145: 133:Cell signaling 130: 129:Known for 126: 125: 106: 102: 101: 100:(aged 81) 94: 90: 89: 80: 67: 65: 61: 60: 45: 42: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 4407: 4396: 4393: 4391: 4388: 4386: 4383: 4381: 4378: 4376: 4373: 4371: 4368: 4366: 4363: 4361: 4358: 4356: 4353: 4351: 4348: 4346: 4343: 4341: 4338: 4336: 4333: 4331: 4328: 4326: 4323: 4321: 4318: 4316: 4313: 4311: 4308: 4306: 4303: 4301: 4298: 4296: 4293: 4291: 4288: 4286: 4283: 4281: 4278: 4276: 4273: 4272: 4270: 4254: 4251: 4248: 4245: 4242: 4239: 4236: 4233: 4230: 4227: 4224: 4221: 4218: 4215: 4212: 4209: 4206: 4203: 4200: 4197: 4194: 4191: 4188: 4187:Van de Pavert 4185: 4182: 4179: 4176: 4173: 4170: 4167: 4164: 4161: 4158: 4155: 4154: 4152: 4148: 4141: 4138: 4135: 4132: 4129: 4126: 4123: 4120: 4117: 4114: 4111: 4108: 4105: 4102: 4099: 4096: 4095: 4093: 4089: 4082: 4079: 4076: 4073: 4070: 4067: 4064: 4061: 4058: 4055: 4052: 4049: 4046: 4043: 4040: 4037: 4034: 4031: 4028: 4025: 4022: 4019: 4016: 4013: 4010: 4007: 4004: 4001: 3998: 3995: 3992: 3989: 3988: 3986: 3982: 3975: 3972: 3969: 3966: 3963: 3960: 3957: 3954: 3951: 3948: 3945: 3942: 3939: 3936: 3933: 3930: 3927: 3924: 3921: 3918: 3915: 3912: 3909: 3906: 3903: 3900: 3897: 3894: 3891: 3888: 3885: 3882: 3881: 3879: 3875: 3868: 3865: 3862: 3859: 3856: 3853: 3850: 3847: 3844: 3841: 3838: 3835: 3832: 3829: 3826: 3823: 3820: 3817: 3814: 3811: 3808: 3805: 3802: 3799: 3796: 3793: 3790: 3787: 3784: 3781: 3778: 3775: 3772: 3769: 3768: 3766: 3762: 3755: 3752: 3749: 3746: 3743: 3740: 3737: 3734: 3731: 3728: 3725: 3722: 3719: 3716: 3713: 3710: 3707: 3704: 3701: 3698: 3695: 3692: 3689: 3686: 3683: 3680: 3677: 3674: 3671: 3668: 3665: 3662: 3659: 3656: 3653: 3649: 3646: 3643: 3640: 3637: 3634: 3631: 3628: 3625: 3622: 3619: 3616: 3613: 3610: 3607: 3604: 3603: 3601: 3597: 3593: 3586: 3581: 3579: 3574: 3572: 3567: 3566: 3563: 3550: 3547: 3544: 3540: 3537: 3534: 3530: 3527: 3524: 3520: 3517: 3514: 3513:David Kazhdan 3510: 3507: 3504: 3501: 3498: 3495: 3492: 3491:Claire Voisin 3488: 3485: 3482: 3481:Nigel Hitchin 3479: 3476: 3472: 3471:Gerd Faltings 3469: 3466: 3463: 3460: 3457: 3454: 3451: 3448: 3444: 3441: 3438: 3437:Jean Bourgain 3435: 3432: 3428: 3425: 3422: 3418: 3415: 3412: 3408: 3405: 3402: 3398: 3397:David Mumford 3395: 3392: 3389: 3386: 3383: 3382: 3380: 3374: 3367: 3363: 3360: 3357: 3353: 3350: 3347: 3343: 3340: 3337: 3334: 3331: 3327: 3323: 3320: 3317: 3314: 3311: 3308: 3305: 3301: 3298: 3295: 3291: 3288: 3285: 3281: 3278: 3275: 3271: 3268: 3265: 3261: 3257: 3254: 3251: 3247: 3244: 3241: 3240:Bruce Beutler 3237: 3233: 3230: 3227: 3224: 3221: 3217: 3214: 3211: 3207: 3203: 3200: 3197: 3194: 3191: 3190:Xiaodong Wang 3188: 3185: 3182: 3179: 3175: 3171: 3170:Herbert Boyer 3167: 3164: 3163: 3161: 3155: 3148: 3145: 3142: 3138: 3134: 3131: 3128: 3124: 3121: 3118: 3114: 3111: 3108: 3105: 3102: 3099: 3096: 3093: 3090: 3087: 3084: 3080: 3076: 3075:Ronald Drever 3073: 3070: 3067: 3064: 3060: 3056: 3053: 3050: 3046: 3045:Steven Balbus 3043: 3040: 3036: 3033: 3030: 3026: 3023: 3020: 3019:David Spergel 3016: 3012: 3009: 3006: 3003: 3000: 2997: 2994: 2991: 2988: 2987:Brian Schmidt 2984: 2980: 2977: 2974: 2970: 2967: 2964: 2961: 2960: 2958: 2954: 2949: 2942: 2937: 2935: 2930: 2928: 2923: 2922: 2919: 2906: 2902: 2899: 2896: 2893: 2890: 2886: 2882: 2879: 2876: 2872: 2869: 2868: 2866: 2862: 2855: 2852: 2849: 2846: 2843: 2839: 2836: 2833: 2829: 2825: 2822: 2819: 2818:Victor Ambros 2815: 2811: 2808: 2805: 2802: 2799: 2795: 2792: 2789: 2786: 2785: 2783: 2779: 2772: 2768: 2765: 2762: 2758: 2754: 2751: 2748: 2744: 2741: 2738: 2734: 2730: 2727: 2724: 2720: 2719:Avram Hershko 2717: 2716: 2714: 2710: 2703: 2700: 2697: 2693: 2690: 2687: 2684: 2681: 2678: 2675: 2671: 2668: 2665: 2664:Judah Folkman 2662: 2659: 2656: 2653: 2650: 2649: 2647: 2643: 2636: 2632: 2629: 2626: 2622: 2621:Henri G. Hers 2619: 2616: 2612: 2609: 2606: 2603: 2600: 2597: 2594: 2590: 2586: 2583: 2580: 2576: 2573: 2570: 2566: 2562: 2559: 2558: 2556: 2552: 2545: 2541: 2537: 2534: 2531: 2527: 2523: 2520: 2519: 2517: 2513: 2509: 2501: 2496: 2494: 2489: 2487: 2482: 2481: 2478: 2459: 2455: 2449: 2446: 2433: 2429: 2425: 2419: 2416: 2403: 2399: 2395: 2389: 2386: 2373: 2369: 2365: 2359: 2356: 2343: 2339: 2335: 2329: 2326: 2313: 2309: 2305: 2299: 2296: 2283: 2279: 2275: 2269: 2266: 2253: 2249: 2248: 2243: 2237: 2234: 2229: 2228: 2223: 2217: 2214: 2201: 2197: 2191: 2188: 2175: 2171: 2167: 2161: 2158: 2145: 2141: 2137: 2131: 2128: 2115: 2111: 2110:Royal Society 2107: 2101: 2098: 2085: 2081: 2075: 2072: 2059: 2055: 2051: 2045: 2042: 2029: 2025: 2021: 2015: 2012: 1999: 1995: 1991: 1985: 1982: 1969: 1965: 1961: 1955: 1952: 1939: 1935: 1931: 1925: 1922: 1909: 1905: 1901: 1895: 1892: 1879: 1875: 1874:Royal Society 1871: 1865: 1862: 1850: 1846: 1842: 1838: 1834: 1830: 1826: 1822: 1821: 1816: 1809: 1806: 1801: 1797: 1793: 1789: 1785: 1781: 1777: 1773: 1769: 1765: 1761: 1757: 1751: 1748: 1736: 1732: 1728: 1724: 1720: 1716: 1712: 1708: 1704: 1700: 1699: 1694: 1687: 1684: 1679: 1675: 1670: 1665: 1661: 1657: 1653: 1649: 1648: 1643: 1639: 1632: 1629: 1617: 1613: 1609: 1605: 1602:(1): 81–147. 1601: 1597: 1596: 1591: 1584: 1581: 1569: 1565: 1561: 1557: 1553: 1549: 1546:(1): 91–104. 1545: 1541: 1540: 1535: 1528: 1525: 1520: 1516: 1511: 1506: 1501: 1496: 1492: 1488: 1484: 1480: 1479: 1474: 1470: 1463: 1460: 1447: 1443: 1439: 1434: 1429: 1425: 1421: 1420: 1415: 1408: 1405: 1393: 1389: 1385: 1381: 1377: 1373: 1369: 1365: 1361: 1357: 1356: 1351: 1344: 1341: 1329: 1325: 1321: 1317: 1313: 1309: 1308: 1303: 1296: 1294: 1290: 1277: 1273: 1269: 1263: 1260: 1247: 1243: 1237: 1235: 1231: 1218: 1214: 1210: 1204: 1201: 1188: 1184: 1180: 1174: 1172: 1170: 1168: 1166: 1162: 1149: 1145: 1141: 1135: 1133: 1129: 1124: 1120: 1115: 1110: 1106: 1102: 1101: 1096: 1089: 1087: 1085: 1083: 1081: 1077: 1071: 1066: 1062: 1058: 1054: 1047: 1044: 1028: 1024: 1017: 1011: 1009: 1007: 1005: 1001: 988: 984: 983: 982:The Telegraph 978: 972: 970: 966: 953: 949: 945: 939: 936: 929: 927: 925: 916: 912: 909: 905: 902: 899: 896: 892: 889: 885: 881: 878: 875: 871: 868: 864: 861: 858: 855: 852: 848: 845: 842: 838: 834: 831: 827: 824: 821: 818: 815: 812: 809: 806: 803: 799: 796: 793: 790: 787: 784: 780: 777: 774: 771: 768: 765: 762: 758: 755: 752: 749: 746: 743: 740: 737: 734: 731: 727: 726:Royal Society 723: 720: 719: 714: 712: 710: 706: 702: 698: 694: 686: 679: 675: 670: 668: 665:. He applied 664: 660: 656: 652: 648: 647:cell membrane 644: 640: 636: 631: 629: 625: 621: 617: 612: 610: 606: 600: 598: 594: 590: 586: 582: 578: 574: 569: 567: 563: 559: 558:physiological 555: 551: 547: 543: 540: 536: 532: 524: 522: 520: 516: 512: 507: 505: 500: 497: 492: 490: 486: 482: 481:John Treherne 477: 475: 471: 467: 463: 459: 455: 451: 447: 443: 442:United States 439: 435: 431: 427: 419: 417: 415: 411: 407: 403: 399: 395: 391: 388: 384: 379: 377: 373: 369: 365: 361: 357: 353: 350: 346: 342: 338: 334: 326: 324: 322: 318: 314: 310: 306: 302: 298: 294: 289: 285: 281: 277: 268: 265: 262: 258: 255: 252: 250: 246: 239: 238: 234: 232: 228: 225: 221: 217: 213: 210: 206: 203: 199: 196: 192: 189: 185: 182: 178: 174: 170: 166: 162: 158: 154: 151: 147: 144: 140: 137:Discovery of 134: 131: 127: 123: 119: 114: 110: 107: 103: 95: 91: 87: 83: 66: 62: 57: 53: 49: 40: 37: 33: 32:Mike Berridge 19: 4247:Van Lieshout 4241:Dröge Wendel 3675: 3549:Peter Sarnak 3523:Jeff Cheeger 3487:János Kollár 3459:David Donoho 3391:Andrew Wiles 3376:Mathematical 3336:Scott D. Emr 3274:Peter Walter 3226:David Julius 3183: 3178:Richard Doll 3174:Yuet-Wai Kan 3159:and medicine 3157:Life science 3083:Rainer Weiss 3025:Enrico Costa 2973:Michel Mayor 2901:Botond Roska 2824:John Kappler 2788:Axel Ullrich 2771:Aharon Razin 2767:Howard Cedar 2692:Michael Sela 2686:Mary F. Lyon 2669: 2615:Meir Wilchek 2536:Roger Sperry 2526:Jean Dausset 2522:George Snell 2462:. Retrieved 2458:the original 2448: 2436:. Retrieved 2432:the original 2418: 2406:. Retrieved 2402:the original 2388: 2376:. Retrieved 2372:the original 2358: 2346:. Retrieved 2342:the original 2328: 2316:. Retrieved 2312:the original 2298: 2286:. Retrieved 2282:the original 2268: 2256:. Retrieved 2252:the original 2245: 2236: 2225: 2216: 2204:. Retrieved 2200:the original 2190: 2178:. Retrieved 2174:the original 2160: 2148:. Retrieved 2144:the original 2130: 2118:. Retrieved 2114:the original 2100: 2088:. Retrieved 2084:the original 2074: 2062:. Retrieved 2058:the original 2044: 2032:. Retrieved 2028:the original 2024:Lasker Award 2014: 2002:. Retrieved 1998:the original 1984: 1972:. Retrieved 1968:the original 1954: 1942:. Retrieved 1938:the original 1924: 1912:. Retrieved 1908:the original 1894: 1882:. Retrieved 1878:the original 1864: 1852:. Retrieved 1824: 1818: 1808: 1767: 1763: 1750: 1738:. Retrieved 1702: 1696: 1686: 1651: 1645: 1631: 1619:. Retrieved 1599: 1593: 1583: 1571:. Retrieved 1543: 1537: 1527: 1482: 1476: 1462: 1450:. Retrieved 1446:the original 1423: 1417: 1407: 1395:. Retrieved 1359: 1353: 1343: 1331:. Retrieved 1311: 1305: 1280:. Retrieved 1276:the original 1262: 1250:. Retrieved 1246:the original 1221:. Retrieved 1217:the original 1203: 1191:. Retrieved 1187:the original 1152:. Retrieved 1148:the original 1104: 1098: 1060: 1056: 1046: 1034:. Retrieved 1027:the original 991:. Retrieved 987:the original 980: 956:. Retrieved 952:the original 938: 921: 820:Massry Prize 671: 667:lithium ions 632: 616:calcium ions 613: 601: 570: 528: 508: 501: 493: 478: 432:) after his 423: 394:tsetse flies 380: 330: 317:calcium ions 293:physiologist 275: 274: 235: 208:Institutions 202:Biochemistry 187: 98:(2020-02-13) 36: 4280:2020 deaths 4275:1938 births 4051:McKitterick 3997:Van der Wee 3356:Eva Nogales 3330:Georg Nagel 3316:Maria Jasin 3304:Ronald Vale 3294:Huda Zoghbi 3290:Adrian Bird 3089:Simon White 2963:Jim Peebles 2881:Joan Steitz 2814:Gary Ruvkun 2761:Tony Pawson 2702:Eric Kandel 2631:John Gurdon 2464:11 November 2408:20 November 2378:20 November 2348:20 November 2318:14 November 2288:20 November 2258:14 November 2222:"No. 54993" 2206:14 November 2180:14 November 2150:14 November 2120:20 November 2064:17 November 2004:17 November 1974:14 November 1944:14 November 1914:14 November 1884:17 November 1854:19 December 1740:19 December 1621:29 November 1573:29 November 1452:28 November 1397:23 November 1333:23 November 1282:19 December 1252:11 November 1223:11 November 1107:(1): 1–21. 993:27 February 792:Royal Medal 659:diglyceride 643:Ca channels 349:high school 173:Royal Medal 4269:Categories 4205:Van Golden 4122:McClelland 3938:Brunekreef 3867:Deisseroth 3789:Montagnier 3630:Van Deenen 3401:Wentsun Wu 3202:Ian Wilmut 3079:Kip Thorne 3059:Shaun Cole 3015:Lyman Page 2983:Adam Riess 2948:Shaw Prize 2696:Ruth Arnon 2438:2 November 2090:29 January 2034:2 November 1193:8 November 1154:7 November 1144:Shaw Prize 1036:3 November 958:6 November 930:References 767:Baly Medal 651:hydrolysed 624:sabbatical 593:difference 581:epithelium 560:effect as 542:cyclic AMP 517:under the 460:Center of 387:physiology 307:acts as a 297:biochemist 198:Physiology 74:1938-10-22 4229:Struycken 4217:B. Visser 4211:Koelewijn 4169:C. Visser 4134:Kanwisher 4110:Tomasello 4027:Schilling 3914:HarremoĂ«s 3861:Carmeliet 3819:Blackburn 3771:Lauterbur 3652:Reichardt 3642:Weissmann 3529:Noga Alon 3005:Frank Shu 2956:Astronomy 2950:laureates 2565:Leo Sachs 1307:BioEssays 1063:: 69–93. 562:serotonin 479:In 1969, 416:in 1965. 390:professor 378:in 1960. 376:chemistry 135:research 105:Education 4098:Anderson 4021:De Vries 3974:Le QuĂ©rĂ© 3950:Laurance 3920:Thompson 3884:Lovelock 3837:Steinman 3801:Marshall 3777:Van Rood 3764:Medicine 3754:Stillman 3730:De Lange 3712:Jeffreys 3676:Berridge 3606:Chargaff 3039:Jane Luu 2739:(2002/3) 2688:(1996/7) 2682:(1995/6) 2676:(1994/5) 2601:(1984/5) 1841:12838335 1758:(1984). 1568:38874406 1471:(1972). 1392:45803569 1328:15666351 1123:15709950 890:) (2000) 804:) (1991) 663:inositol 554:blow fly 525:Research 430:Zimbabwe 345:Zimbabwe 4223:Manders 4181:Martens 4157:Verhoef 4140:Zatorre 4104:Dehaene 4075:McNeill 4063:Assmann 4033:Le Goff 4009:Oberman 3984:History 3908:Ehrlich 3890:Branica 3855:Jackson 3849:Alitalo 3843:Clevers 3795:De Wied 3783:Moncada 3718:Szostak 3694:Rothman 3624:De Duve 3612:Brachet 3378:science 1849:1152297 1800:4240505 1792:6232463 1772:Bibcode 1735:4359904 1727:6605482 1707:Bibcode 1678:6309146 1669:1152070 1560:6266901 1519:4335064 1487:Bibcode 1442:4339528 1384:4300804 1364:Bibcode 1355:Science 882:of the 865:of the 849:of the 781:of the 724:of the 645:on the 597:charged 589:osmosis 489:Zoology 474:Biology 448:of the 446:Biology 372:zoology 352:biology 347:). 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Index

Sir Michael Berridge
Mike Berridge
FRS
FMedSci
FBPhS
Gatooma
Southern Rhodesia
University College of Rhodesia and Nyasaland
Bsc
University College
PhD
Cell signaling
inositol trisphosphate
second messenger
King Faisal International Prize in Science
Louis-Jeantet Prize for Medicine
Knight Bachelor
Canada Gairdner International Award
Albert Lasker Award for Basic Medical Research
Royal Medal
Dr H. P. Heineken Prize for Biochemistry and Biophysics
Shaw Prize in Life Science and Medicine
Physiology
Biochemistry
University of Virginia
Case Western Reserve University
University of Cambridge
Babraham Institute
Thesis
The physiology of excretion in the cotton stainer, Dysdercus fasciatus Signoret (Hemiptera, Pyrrhocoridae)

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