516:
1143:
1235:
31:
1108:
SIRT3, a mitochondrial protein deacetylase, plays a role in the regulation of multiple metabolic proteins like isocitrate dehydrogenase of the TCA cycle. It also plays a role in skeletal muscle as a metabolic adaptive response. Since glutamine is a source of a-ketoglutarate used to replenish the TCA
612:
The first sirtuin was identified in yeast (a lower eukaryote) and named sir2. In more complex mammals, there are seven known enzymes that act in cellular regulation, as sir2 does in yeast. These genes are designated as belonging to different classes (I-IV), depending on their amino acid sequence
485:
is the name of one of the sirtuin-type proteins (see table below). Mammals possess seven sirtuins (SIRT1–7) that occupy different subcellular compartments: SIRT1, SIRT6 and SIRT7 are predominantly in the nucleus, SIRT2 in the cytoplasm, and SIRT3, SIRT4 and SIRT5 in the mitochondria.
1305:. SIRT6 deficiency in mice leads to a degenerative aging-like phenotype. In addition, SIRT6 promotes the repair of DNA double-strand breaks. Furthermore, over-expression of SIRT6 can stimulate homologous recombinational repair.
458:. The dependence of sirtuins on NAD+ links their enzymatic activity directly to the energy status of the cell via the cellular NAD+:NADH ratio, the absolute levels of NAD+, NADH or NAM or a combination of these variables.
4694:
5721:
3680:
4120:
4115:
481:
structure throughout all kingdoms of life. Whereas bacteria and archaea encode either one or two sirtuins, eukaryotes encode several sirtuins in their genomes. In yeast, roundworms, and fruitflies,
502:. Interest in the metabolism of NAD heightened after the year 2000 discovery by Shin-ichiro Imai and coworkers in the Guarente laboratory that sirtuins are NAD+-dependent protein deacetylases .
4687:
619:
possess sirtuins that are intermediate in sequence between classes, and these are placed in the "undifferentiated" or "U" class. In addition, several Gram positive bacteria, including
4493:
638:
Yeast protein names may also be suffixed with "p" (e.g. Sir2p) to indicate the fact that it is a protein. This table does not use this convention to minimize cross-species confusion.
4680:
4369:
4160:
3673:
1153:
5595:
179:
4474:
3666:
4542:
3991:
4703:
1975:
Rack JG, Morra R, Barkauskaite E, Kraehenbuehl R, Ariza A, Qu Y, Ortmayer M, Leidecker O, Cameron DR, Matic I, Peleg AY, Leys D, Traven A, Ahel I (July 2015).
4651:
2721:
Zhao K, Chai X, Marmorstein R (March 2004). "Structure and substrate binding properties of cobB, a Sir2 homolog protein deacetylase from
Escherichia coli".
4621:
4746:
2506:
Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000). "Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase".
5191:
4296:
4291:
1856:
Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H (November 2011).
5698:
5334:
5242:
5139:
4853:
4809:
5656:
4736:
4656:
2083:"SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus"
2026:
3909:
828:
Neurodegenerative diseases, Cancer: B cell chronic lymphocytic leukemia, mantle cell lymphoma, chronic lymphocytic leukemia, breast, gastric
499:
127:
5635:
5558:
477:
Sirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a
5678:
3984:
5087:
4537:
745:
Neurodegenerative diseases, Cancer: acute myeloid leukemia, colon, prostate, ovarian, glioma, breast, melanoma, lung adenocarcinoma
599:
439:
5217:
4547:
1302:
5590:
5751:
4568:
3631:
Rôle de la sirtuine 1 dans la modulation des réponses apoptotique et autophagique du coeur au stress du réticulum endoplasmique
2247:
2662:
Carafa V, Rotili D, Forgione M, Cuomo F, Serretiello E, Hailu GS, Jarho E, Lahtela-Kakkonen M, Mai A, Altucci L (2016-05-25).
1913:
Jiang H, Khan S, Wang Y, Charron G, He B, Sebastian C, Du J, Kim R, Ge E, Mostoslavsky R, Hang HC, Hao Q, Lin H (April 2013).
5746:
5646:
4848:
4824:
4804:
4552:
3884:
537:
5453:
199:
5405:
4858:
3977:
2993:
Uhl M, Csernok A, Aydin S, Kreienberg R, Wiesmüller L, Gatz SA (April 2010). "Role of SIRT1 in homologous recombination".
1697:"Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases"
5611:
5586:
5577:
5439:
5092:
4087:
1161:
4719:
4072:
1214:
580:
5470:
1186:
552:
4512:
3846:
3517:"Curcumin elevates sirtuin level but does not postpone in vitro senescence of human cells building the vasculature"
1328:, which binds to a specific receptor site. It is an inhibitor in vitro of SIRT1, but can be a stimulator in cells.
1313:
1172:
1157:
526:
4637:
4529:
4442:
4077:
4017:
3944:
3921:
3856:
3823:
3790:
3702:
340:
structure throughout all kingdoms of life. Chemically, sirtuins are a class of proteins that possess either mono-
5693:
5280:
4783:
4765:
4082:
4055:
4008:
3693:
3652:
3242:"Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme"
1283:
1193:
1018:
559:
533:
394:
187:
5486:
5196:
5166:
5151:
5114:
4572:
4135:
3763:
1126:
466:
410:
2320:"Structural and chemical biology of deacetylases for carbohydrates, proteins, small molecules and histones"
4774:
4050:
1655:
627:
1200:
566:
5567:
5378:
5146:
4616:
4102:
4092:
3131:"Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence"
621:
48:
461:
Sirtuins that deacetylate histones are structurally and mechanistically distinct from other classes of
183:
2559:"Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle"
613:
structure. Several gram positive prokaryotes as well as the gram negative hyperthermophilic bacterium
4970:
4484:
4311:
4045:
3894:
3420:
3142:
2515:
1926:
1869:
1708:
1298:
454:
of sirtuin activity itself. These proteins utilize NAD+ to maintain cellular health and turn NAD+ to
413:
that sirtuins affect human aging, and a 2022 review criticized researchers who propagate this claim.
333:
140:
2460:
2038:
Preyat N, Leo O (May 2013). "Sirtuin deacylases: a molecular link between metabolism and immunity".
1392:
1182:
548:
5549:
5422:
4446:
4361:
4259:
4032:
4004:
3874:
3773:
3658:
1660:
1309:
615:
462:
417:
406:
52:
3566:"Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK"
4955:
4920:
4599:
4283:
4021:
3899:
3062:
2877:
2539:
2441:
2063:
478:
337:
4672:
2081:
Satoh A, Brace CS, Ben-Josef G, West T, Wozniak DF, Holtzman DM, Herzog ED, Imai S (July 2010).
3082:"SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair"
4843:
4799:
4641:
4067:
3969:
3869:
3595:
3546:
3497:
3446:
3374:
3314:
3263:
3222:
3170:
3111:
3054:
3010:
2975:
2926:
2869:
2828:
2779:
2738:
2703:
2685:
2639:
2588:
2531:
2433:
2398:
2349:
2276:
2213:
2172:
2154:
2112:
2055:
2006:
1952:
1895:
1838:
1794:
1736:
1685:
1561:
1256:
206:
174:
2429:
5741:
4814:
4792:
4788:
4479:
4466:
4110:
4060:
3585:
3577:
3536:
3528:
3487:
3477:
3436:
3428:
3364:
3354:
3304:
3294:
3253:
3212:
3204:
3160:
3150:
3101:
3093:
3044:
3002:
2965:
2957:
2916:
2908:
2859:
2818:
2810:
2769:
2730:
2693:
2675:
2629:
2619:
2578:
2570:
2523:
2425:
2388:
2380:
2339:
2331:
2266:
2256:
2221:
2203:
2162:
2146:
2102:
2094:
2047:
1996:
1988:
1942:
1934:
1885:
1877:
1828:
1784:
1776:
1726:
1716:
742:
Hif-1α, Hif-2α, MYC, P53, BRCA1, FOXO3A, MyoD, Ku70, PPARγ, PCAF, Suv39h1, TGFB1, WRN, NBS1
495:
451:
341:
5511:
5052:
4351:
4346:
166:
5534:
5529:
5290:
5285:
5261:
5256:
5222:
5119:
5047:
4871:
4498:
3751:
2243:"Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators"
3424:
3309:
3282:
3146:
2519:
2226:
1930:
1873:
1712:
357:
5233:
3926:
3889:
3861:
3813:
3808:
3795:
3745:
3707:
3590:
3565:
3541:
3516:
3492:
3465:
3441:
3408:
3369:
3342:
3217:
3192:
3165:
3130:
3106:
3081:
2970:
2945:
2921:
2896:
2823:
2798:
2698:
2663:
2634:
2607:
2393:
2368:
2344:
2319:
2271:
2242:
2167:
2134:
2107:
2082:
2001:
1977:"Identification of a Class of Protein ADP-Ribosylating Sirtuins in Microbial Pathogens"
1976:
1947:
1914:
1890:
1857:
1789:
1764:
1665:
389:
studies, sirtuins were thought to be implicated in influencing cellular processes like
326:
2583:
2558:
1731:
1696:
349:
5735:
5312:
5251:
5124:
4503:
4040:
3953:
3879:
3828:
3193:"SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair"
1621:
1453:
1207:
1015:
573:
435:
421:
132:
3648:
3066:
2881:
2574:
2445:
1915:"SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine"
353:
83:
5268:
5106:
3735:
3715:
2543:
2485:
2098:
2067:
1573:
1325:
632:
455:
447:
402:
162:
3283:"Nicotinamide is an inhibitor of SIRT1 in vitro, but can be a stimulator in cells"
2961:
465:(classes I, IIA, IIB and IV), which have a different protein fold and use Zn as a
96:
3258:
3241:
3006:
1992:
108:
5171:
4741:
4000:
3803:
3730:
3720:
3629:
3564:
Sandoval-Rodriguez A, Monroy-Ramirez HC, Meza-Rios A, et al. (March 2020).
3033:"Genomic instability and aging-like phenotype in the absence of mammalian SIRT6"
1525:
1489:
1356:
1245:
1118:
515:
3432:
3135:
Proceedings of the
National Academy of Sciences of the United States of America
3049:
3032:
2774:
2757:
2624:
2208:
1701:
Proceedings of the
National Academy of Sciences of the United States of America
1244:
A 2018 review indicated that SIRT levels are lower in tissues from people with
5361:
5156:
4833:
3958:
3841:
3758:
3359:
3299:
2912:
2814:
2734:
2680:
2335:
2261:
1780:
1404:
1279:
1056:
424:
345:
59:
peptide (magenta) containing an acylated lysine residue (displayed as spheres)
56:
44:
40:
5683:
3532:
2689:
2217:
2158:
5625:
4838:
4756:
3934:
3689:
3208:
3155:
1881:
1721:
1585:
1501:
1416:
1294:
1267:
1125:, led some scientists to speculate that resveratrol may extend lifespan, no
398:
55:, carbon = white, oxygen = red, nitrogen = blue, phosphorus = orange) and a
3599:
3550:
3501:
3464:
Rahnasto-Rilla MK, McLoughlin P, Kulikowicz T, et al. (21 June 2017).
3450:
3378:
3318:
3267:
3226:
3174:
3115:
3058:
3014:
2979:
2930:
2873:
2832:
2783:
2742:
2707:
2643:
2592:
2535:
2437:
2402:
2353:
2294:
2280:
2191:
2176:
2116:
2059:
2010:
1956:
1899:
1842:
1798:
1740:
3466:"The Identification of a SIRT6 Activator from Brown Algae Fucus distichus"
3097:
2150:
136:
3836:
2416:
Blander G, Guarente L (2004). "The Sir2 family of protein deacetylases".
2135:"Emerging anti-aging strategies - scientific basis and efficacy (Review)"
1833:
1816:
1609:
1597:
1537:
1513:
1477:
1465:
1429:
1380:
1368:
1253:
1249:
405:
and stress resistance, as well as energy efficiency and alertness during
385:
103:
2051:
1938:
1858:"Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase"
5703:
5427:
5273:
4661:
4252:
4247:
4242:
4237:
4232:
4200:
4124:
3482:
3129:
Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A (July 2012).
1633:
1441:
1171:
if you can. Unsourced or poorly sourced material may be challenged and
981:
964:
Demyristoylase, depalmitoylase, ADP-ribosyl transferase and deacetylase
819:
782:
778:
737:
540: in this section. Unsourced material may be challenged and removed.
329:
115:
3581:
2864:
2847:
2384:
1689:
308:
302:
296:
290:
284:
278:
272:
266:
260:
254:
248:
242:
236:
230:
224:
218:
212:
5708:
5496:
5491:
5201:
4457:
4227:
4222:
4217:
4212:
4207:
4195:
4190:
4185:
4180:
4175:
4170:
4165:
4153:
4148:
4143:
3725:
2527:
2023:
1549:
977:
733:
443:
432:
428:
194:
120:
2557:
Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA (May 2003).
1312:. SIRT7 protein is required for repair of double-strand breaks by
5506:
5501:
5463:
5448:
5415:
5410:
5371:
5366:
5354:
5349:
5344:
5339:
5327:
5305:
5300:
5295:
5072:
5067:
5062:
5057:
5017:
5012:
4950:
4945:
4940:
4935:
4910:
4905:
4900:
4895:
4890:
4885:
4880:
4609:
4604:
4577:
4428:
4379:
4374:
3904:
3407:
Rahnasto-Rilla M, Tyni J, Huovinen M, et al. (7 March 2018).
1275:
1271:
1122:
1004:
956:
915:
875:
802:
761:
716:
390:
377:
3031:
Mostoslavsky R, Chua KF, Lombard DB, et al. (January 2006).
5688:
5673:
5458:
5398:
5393:
5388:
5383:
5322:
5317:
5161:
5134:
5129:
5042:
5037:
5032:
5027:
5022:
4999:
4994:
4989:
4984:
4979:
4930:
4925:
4915:
4423:
4418:
4413:
4408:
4403:
4398:
4391:
4386:
4341:
4336:
4331:
4326:
4321:
4316:
4306:
4301:
4273:
4268:
4263:
3768:
3740:
3343:"SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases"
2664:"Sirtuin functions and modulation: from chemistry to the clinic"
2488:. Massachusetts Institute of Technology, News Office. 2000-02-16
1042:
482:
156:
90:
78:
36:
4676:
4121:
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
4116:
B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase
3973:
3662:
2486:"MIT researchers uncover new information about anti-aging gene"
336:. They are ancient in animal evolution and appear to possess a
30:
3191:
Vazquez BN, Thackray JK, Simonet NG, et al. (July 2016).
1287:
1136:
968:
509:
431:
residues, the sirtuin-mediated deacetylation reaction couples
5722:
deficiencies of intracellular signaling peptides and proteins
3080:
McCord RA, Michishita E, Hong T, et al. (January 2009).
2369:"Histone deacetylase inhibitors: Potential in cancer therapy"
3515:
Grabowska W, Suszek M, Wnuk M, et al. (28 March 2016).
2295:"NMN vs NR: The Differences Between These 2 NAD+ Precursors"
1286:
in human cells and is involved in recombinational repair of
3402:
3400:
3398:
3396:
3394:
3392:
3390:
3388:
2846:
Aunan JR, Watson MM, Hagland HR, Søreide K (January 2016).
1763:
Ye X, Li M, Hou T, Gao T, Zhu WG, Yang Y (3 January 2017).
1297:-associated protein and in mammalian cells is required for
2608:"SIRT6, a Mammalian Deacylase with Multitasking Abilities"
938:
Cancer: pancreatic, breast, non-small cell lung carcinoma
3634:(phdthesis) (in French). Université Paris Saclay (COmUE).
790:
Neurodegenerative diseases, Cancer: brain tissue, glioma
420:. Unlike other known protein deacetylases, which simply
1168:
4370:
Dolichyl-phosphate-mannose-protein mannosyltransferase
2758:"Conserved metabolic regulatory functions of sirtuins"
1695:
Zhao K, Harshaw R, Chai X, Marmorstein R (June 2004).
2946:"Sirtuins and DNA damage repair: SIRT7 comes to play"
1248:, and such reduced SIRT levels may increase risk of
1129:
for such an effect has been discovered, as of 2018.
5666:
5645:
5624:
5604:
5576:
5557:
5547:
5522:
5479:
5438:
5241:
5231:
5210:
5184:
5105:
4823:
4773:
4764:
4755:
4729:
4710:
4636:
4592:
4561:
4528:
4465:
4456:
4441:
4360:
4282:
4134:
4101:
4031:
4016:
3943:
3920:
3855:
3822:
3789:
3701:
494:Research on sirtuin protein was started in 1991 by
376:', the gene responsible for cellular regulation in
360:
activity. The name Sir2 comes from the yeast gene '
205:
193:
173:
155:
150:
126:
114:
102:
89:
77:
69:
64:
23:
5596:Sh2 domain-containing protein tyrosine phosphatase
2606:Chang AR, Ferrer CM, Mostoslavsky R (2020-01-01).
1815:Yamamoto H, Schoonjans K, Auwerx J (August 2007).
1109:cycle, SIRT4 is involved in glutamine metabolism.
442:+ hydrolysis. This hydrolysis yields O-acetyl-ADP-
3341:Manjula R, Anuja K, Alcain FJ (12 January 2021).
2944:Vazquez BN, Thackray JK, Serrano L (March 2017).
2133:Shetty AK, Kodali M, Upadhya R, Madhu LN (2018).
3240:Avalos JL, Bever KM, Wolberger C (March 2005).
3186:
3184:
3026:
3024:
2897:"Sirtuins and accelerated aging in scleroderma"
1032:Cancer: liver, testis, spleen, thyroid, breast
416:Yeast Sir2 and some, but not all, sirtuins are
4543:Hypoxanthine-guanine phosphoribosyltransferase
3336:
3334:
3332:
3330:
3328:
2848:"Molecular and biological hallmarks of ageing"
1810:
1808:
1167:Please review the contents of the section and
635:-linked sirtuins (termed "class M" sirtuins).
4704:Intracellular signaling peptides and proteins
4688:
3985:
3674:
3409:"Natural polyphenols as sirtuin 6 modulators"
2803:Current Opinion in Genetics & Development
8:
4652:Beta-galactoside alpha-2,6-sialyltransferase
2192:"Sirtuins are not conserved longevity genes"
4622:Indolylacetylinositol arabinosyltransferase
923:Demalonylase, desuccinylase and deacetylase
5591:Receptor-like protein tyrosine phosphatase
5554:
5238:
4770:
4761:
4695:
4681:
4673:
4462:
4453:
4028:
3992:
3978:
3970:
3681:
3667:
3659:
3623:
3621:
3619:
3617:
3615:
3613:
3611:
3609:
1765:"Sirtuins in glucose and lipid metabolism"
1335:
147:
29:
5192:Cyclin-dependent kinase inhibitor protein
3651:at the U.S. National Library of Medicine
3589:
3540:
3491:
3481:
3440:
3368:
3358:
3308:
3298:
3257:
3216:
3164:
3154:
3105:
3048:
2969:
2920:
2863:
2822:
2773:
2697:
2679:
2633:
2623:
2582:
2392:
2343:
2270:
2260:
2225:
2207:
2166:
2128:
2126:
2106:
2000:
1946:
1889:
1832:
1817:"Sirtuin functions in health and disease"
1788:
1730:
1720:
1324:Certain sirtuin activity is inhibited by
600:Learn how and when to remove this message
5699:Phosphatidylethanolamine binding protein
5335:Interleukin-1 receptor associated kinase
4747:Ca2+/calmodulin-dependent protein kinase
2430:10.1146/annurev.biochem.73.011303.073651
1758:
1756:
1754:
1752:
1750:
1308:SIRT7 knockout mice display features of
640:
1677:
1121:, an activator of deacetylases such as
787:Tubulin, Foxo3a, EIF5A, P53, G6PD, MYC
660:
657:
5454:Focal adhesion protein-tyrosine kinase
4737:Intracellular calcium-sensing proteins
4657:Monosialoganglioside sialyltransferase
4494:NAD(P):arginine ADP-ribosyltransferase
4475:NAD:diphthamide ADP-ribosyltransferase
2799:"Sirtuins, metabolism, and DNA repair"
20:
3910:Activation-induced cytidine deaminase
2797:Choi JE, Mostoslavsky R (June 2014).
2657:
2655:
2653:
7:
3281:Hwang ES, Song SB (September 2017).
2756:Schwer B, Verdin E (February 2008).
1970:
1968:
1966:
538:adding citations to reliable sources
35:Crystallographic structure of yeast
5679:Signal transducing adaptor protein
4854:3',5'-cyclic-GMP phosphodiesterase
4810:3',5'-cyclic-AMP phosphodiesterase
2895:Wyman AE, Atamas SP (March 2018).
2461:"The quest for a way around aging"
1117:Although preliminary studies with
14:
5674:Activating transcription factor 6
5088:G protein-coupled receptor kinase
4538:Adenine phosphoribosyltransferase
631:, as well as several fungi carry
446:, the deacetylated substrate and
348:activity, including deacetylase,
5218:Phosphoinositide phospholipase C
4548:Uracil phosphoribosyltransferase
2373:Journal of Cellular Biochemistry
1337:List of known sirtuin activator
1263:DNA repair in laboratory studies
1233:
1141:
675:Non-Histone Deacetylation Target
514:
473:Actions and species distribution
4569:Purine nucleoside phosphorylase
3692:: carbon-nitrogen non-peptide (
2575:10.1128/MCB.23.9.3173-3185.2003
2248:Journal of Biological Chemistry
525:needs additional citations for
5657:GTP-binding protein regulators
5647:GTP-binding protein regulators
4553:Amidophosphoribosyltransferase
3885:Inosine monophosphate synthase
2852:The British Journal of Surgery
2563:Molecular and Cellular Biology
2467:. International Herald Tribune
2099:10.1523/JNEUROSCI.1385-10.2010
1169:add the appropriate references
825:SOD2, PDH, IDH2, GOT2, FoxO3a
1:
5406:Rho-associated protein kinase
2962:10.1080/19491034.2016.1264552
2418:Annual Review of Biochemistry
2367:Marks PA, Xu WS (July 2009).
1661:Histone deacetylases or HDACs
151:Available protein structures:
5612:Dual-specificity phosphatase
5587:protein tyrosine phosphatase
5093:AMP-activated protein kinase
4088:Ceramide glucosyltransferase
3259:10.1016/j.molcel.2005.02.022
3007:10.1016/j.dnarep.2009.12.020
2901:Current Rheumatology Reports
2723:Journal of Molecular Biology
2040:Journal of Leukocyte Biology
1993:10.1016/j.molcel.2015.06.013
670:Histone Deacetylation Target
5636:apoptosis signaling pathway
3628:da Silva JP (31 May 2018).
2087:The Journal of Neuroscience
1154:reliable medical references
898:Cancer: breast, colorectal
409:. As of 2018, there was no
5768:
4513:Poly ADP ribose polymerase
3847:Protein-arginine deiminase
3769:Fatty acid amide hydrolase
3433:10.1038/s41598-018-22388-5
3050:10.1016/j.cell.2005.11.044
2775:10.1016/j.cmet.2007.11.006
2625:10.1152/physrev.00030.2018
2318:Bürger M, Chory J (2018).
2241:Klein MA, Denu JM (2020).
1314:non-homologous end joining
1282:. SIRT1 protein promotes
1252:through modulation of the
772:Cell cycle, tumorigenesis
637:
39:(rainbow colored cartoon,
5717:
5480:Serine/threonine/tyrosine
5083:
4966:
4867:
4530:Phosphoribosyltransferase
3570:Hepatology Communications
3360:10.3389/fphar.2020.585821
3347:Frontiers in Pharmacology
3300:10.1007/s00018-017-2527-8
2913:10.1007/s11926-018-0724-6
2815:10.1016/j.gde.2014.05.005
2735:10.1016/j.jmb.2004.01.060
2681:10.1186/s13148-016-0224-3
2336:10.1038/s42003-018-0214-4
2262:10.1074/jbc.REV120.011438
1781:10.18632/oncotarget.12157
1278:proteins are employed in
1160:or relies too heavily on
942:
749:
699:
678:
673:
668:
663:
652:
649:
646:
643:
146:
28:
5694:Olfactory marker protein
5281:Glycogen synthase kinase
4784:Heterotrimeric G protein
4083:1,3-Beta-glucan synthase
3653:Medical Subject Headings
3533:10.18632/oncotarget.8450
2209:10.1093/lifemeta/loac025
2190:Brenner C (2022-09-22).
1284:homologous recombination
1091:ADP-ribosyl transferase
967:DNA repair, metabolism,
727:Metabolism inflammation
5487:Dual-specificity kinase
5197:Cyclin-dependent kinase
4573:Thymidine phosphorylase
3764:Aspartylglucosaminidase
3209:10.15252/embj.201593499
3156:10.1073/pnas.1200583109
1882:10.1126/science.1207861
1821:Molecular Endocrinology
1722:10.1073/pnas.0401057101
926:Ammonia detoxification
883:ADP-ribosyl transferase
5752:Aging-related proteins
4467:ADP-ribosyltransferase
2324:Communications Biology
1656:Biological immortality
989:Cancer: breast, colon
628:Streptococcus pyogenes
407:low-calorie situations
342:ADP-ribosyltransferase
47:= red) complexed with
5747:Aging-related enzymes
5568:Protein phosphatase 2
5379:p21-activated kinases
4617:Arabinosyltransferase
4093:N-glycosyltransferase
3098:10.18632/aging.100011
2854:(Review (in vitro)).
2612:Physiological Reviews
2459:Wade N (2006-11-08).
2151:10.14336/ad.2018.1026
1419:and rutin derivatives
766:Nucleus and cytoplasm
622:Staphylococcus aureus
356:, demyristoylase and
4971:G beta-gamma complex
4485:Pseudomonas exotoxin
4005:glycosyltransferases
3895:GTP cyclohydrolase I
2668:Clinical Epigenetics
2465:Health & Science
1834:10.1210/me.2007-0079
1299:base excision repair
534:improve this article
463:histone deacetylases
418:protein deacetylases
334:metabolic regulation
5550:protein phosphatase
5423:Ribosomal s6 kinase
4260:Hyaluronan synthase
3875:Adenosine deaminase
3774:Histone deacetylase
3527:(15): 19201–19213.
3425:2018NatSR...8.4163R
3147:2012PNAS..10911800M
2520:2000Natur.403..795I
2255:(32): 11021–11041.
2052:10.1189/jlb.1112557
1939:10.1038/nature12038
1931:2013Natur.496..110J
1874:2011Sci...334..806D
1713:2004PNAS..101.8563Z
1341:
1094:ROS detoxification
816:126-382 (of 399aa)
730:244-498 (of 766aa)
616:Thermotoga maritima
53:space-filling model
4720:MAP kinase pathway
4600:Xylosyltransferase
4073:Debranching enzyme
3900:Cytidine deaminase
3859:: Cyclic amidines/
3826:: Linear amidines/
3483:10.3390/md15060190
3413:Scientific Reports
1348:Target/Specificity
1336:
1023:90-331 (of 400aa)
974:35-274 (of 355aa)
929:41-309 (of 310aa)
889:45-314 (of 314aa)
886:Insulin secretion
775:65-340 (of 388aa)
721:Nucleus, cytoplasm
661:Cellular Function
456:nicotinamide (NAM)
364:ilent mating-type
5729:
5728:
5684:I-kappa B protein
5620:
5619:
5543:
5542:
5180:
5179:
5101:
5100:
4844:Guanylate cyclase
4800:Adenylate cyclase
4670:
4669:
4632:
4631:
4588:
4587:
4437:
4436:
4068:Glycogen synthase
3967:
3966:
3870:Guanine deaminase
3705:: Linear amides /
3582:10.1002/hep4.1474
3293:(18): 3347–3362.
3287:Cell Mol Life Sci
2865:10.1002/bjs.10053
2514:(6771): 795–800.
2385:10.1002/jcb.22185
2139:Aging and Disease
1644:
1643:
1562:Isoliquiritigenin
1257:signaling pathway
1242:
1241:
1218:
1127:clinical evidence
1106:
1105:
665:Catalytic Domains
610:
609:
602:
584:
411:clinical evidence
320:
319:
316:
315:
200:structure summary
5759:
5559:Serine/threonine
5555:
5243:Serine/threonine
5239:
4859:Protein kinase G
4815:Protein kinase A
4771:
4762:
4697:
4690:
4683:
4674:
4480:Diphtheria toxin
4463:
4454:
4111:Lactose synthase
4078:Branching enzyme
4029:
3994:
3987:
3980:
3971:
3793:: Cyclic amides/
3683:
3676:
3669:
3660:
3636:
3635:
3625:
3604:
3603:
3593:
3561:
3555:
3554:
3544:
3512:
3506:
3505:
3495:
3485:
3461:
3455:
3454:
3444:
3404:
3383:
3382:
3372:
3362:
3338:
3323:
3322:
3312:
3302:
3278:
3272:
3271:
3261:
3237:
3231:
3230:
3220:
3203:(14): 1488–503.
3197:The EMBO Journal
3188:
3179:
3178:
3168:
3158:
3126:
3120:
3119:
3109:
3077:
3071:
3070:
3052:
3028:
3019:
3018:
2990:
2984:
2983:
2973:
2941:
2935:
2934:
2924:
2892:
2886:
2885:
2867:
2843:
2837:
2836:
2826:
2794:
2788:
2787:
2777:
2753:
2747:
2746:
2718:
2712:
2711:
2701:
2683:
2659:
2648:
2647:
2637:
2627:
2603:
2597:
2596:
2586:
2554:
2548:
2547:
2528:10.1038/35001622
2503:
2497:
2496:
2494:
2493:
2482:
2476:
2475:
2473:
2472:
2456:
2450:
2449:
2413:
2407:
2406:
2396:
2364:
2358:
2357:
2347:
2315:
2309:
2308:
2306:
2305:
2291:
2285:
2284:
2274:
2264:
2238:
2232:
2231:
2229:
2211:
2187:
2181:
2180:
2170:
2145:(6): 1165–1184.
2130:
2121:
2120:
2110:
2093:(30): 10220–32.
2078:
2072:
2071:
2035:
2029:
2021:
2015:
2014:
2004:
1972:
1961:
1960:
1950:
1910:
1904:
1903:
1893:
1853:
1847:
1846:
1836:
1812:
1803:
1802:
1792:
1775:(1): 1845–1859.
1760:
1745:
1744:
1734:
1724:
1692:
1682:
1342:
1237:
1236:
1228:
1225:
1219:
1217:
1176:
1145:
1144:
1137:
641:
605:
598:
594:
591:
585:
583:
542:
518:
510:
496:Leonard Guarente
479:highly conserved
338:highly conserved
325:are a family of
311:
305:
299:
293:
287:
281:
275:
269:
263:
257:
251:
245:
239:
233:
227:
221:
215:
148:
33:
21:
5767:
5766:
5762:
5761:
5760:
5758:
5757:
5756:
5732:
5731:
5730:
5725:
5713:
5662:
5641:
5616:
5600:
5572:
5539:
5530:Arginine kinase
5518:
5475:
5434:
5227:
5223:Phospholipase C
5206:
5176:
5097:
5079:
5009:
4976:
4962:
4877:
4872:G alpha subunit
4863:
4819:
4751:
4725:
4706:
4701:
4671:
4666:
4643:
4628:
4584:
4557:
4524:
4499:Pertussis toxin
4448:
4433:
4356:
4278:
4130:
4097:
4023:
4012:
3998:
3968:
3963:
3939:
3927:Aminohydrolases
3925:
3916:
3862:Aminohydrolases
3860:
3851:
3827:
3818:
3796:Amidohydrolases
3794:
3785:
3708:Amidohydrolases
3706:
3697:
3687:
3645:
3640:
3639:
3627:
3626:
3607:
3563:
3562:
3558:
3514:
3513:
3509:
3463:
3462:
3458:
3406:
3405:
3386:
3340:
3339:
3326:
3280:
3279:
3275:
3239:
3238:
3234:
3190:
3189:
3182:
3141:(29): 11800–5.
3128:
3127:
3123:
3079:
3078:
3074:
3030:
3029:
3022:
2992:
2991:
2987:
2943:
2942:
2938:
2894:
2893:
2889:
2845:
2844:
2840:
2796:
2795:
2791:
2762:Cell Metabolism
2755:
2754:
2750:
2720:
2719:
2715:
2661:
2660:
2651:
2605:
2604:
2600:
2556:
2555:
2551:
2505:
2504:
2500:
2491:
2489:
2484:
2483:
2479:
2470:
2468:
2458:
2457:
2453:
2415:
2414:
2410:
2366:
2365:
2361:
2317:
2316:
2312:
2303:
2301:
2293:
2292:
2288:
2240:
2239:
2235:
2196:Life Metabolism
2189:
2188:
2184:
2132:
2131:
2124:
2080:
2079:
2075:
2037:
2036:
2032:
2022:
2018:
1974:
1973:
1964:
1925:(7443): 110–3.
1912:
1911:
1907:
1868:(6057): 806–9.
1855:
1854:
1850:
1814:
1813:
1806:
1762:
1761:
1748:
1694:
1684:
1683:
1679:
1674:
1652:
1646:
1334:
1322:
1310:premature aging
1265:
1238:
1234:
1229:
1223:
1220:
1177:
1166:
1162:primary sources
1146:
1142:
1135:
1133:Tissue fibrosis
1115:
1029:Hif-1α, Hif-2α
839:
709:
654:
639:
606:
595:
589:
586:
543:
541:
531:
519:
508:
492:
475:
307:
301:
295:
289:
283:
277:
271:
265:
259:
253:
247:
241:
235:
229:
223:
217:
211:
60:
17:
12:
11:
5:
5765:
5763:
5755:
5754:
5749:
5744:
5734:
5733:
5727:
5726:
5718:
5715:
5714:
5712:
5711:
5706:
5701:
5696:
5691:
5686:
5681:
5676:
5670:
5668:
5664:
5663:
5661:
5660:
5651:
5649:
5643:
5642:
5640:
5639:
5630:
5628:
5622:
5621:
5618:
5617:
5615:
5614:
5608:
5606:
5602:
5601:
5599:
5598:
5593:
5583:
5581:
5574:
5573:
5571:
5570:
5564:
5562:
5552:
5545:
5544:
5541:
5540:
5538:
5537:
5532:
5526:
5524:
5520:
5519:
5517:
5516:
5515:
5514:
5509:
5504:
5499:
5494:
5483:
5481:
5477:
5476:
5474:
5473:
5468:
5467:
5466:
5461:
5451:
5445:
5443:
5436:
5435:
5433:
5432:
5431:
5430:
5420:
5419:
5418:
5413:
5403:
5402:
5401:
5396:
5391:
5386:
5376:
5375:
5374:
5369:
5359:
5358:
5357:
5352:
5347:
5342:
5332:
5331:
5330:
5325:
5320:
5310:
5309:
5308:
5303:
5298:
5293:
5288:
5278:
5277:
5276:
5266:
5265:
5264:
5259:
5248:
5246:
5236:
5234:protein kinase
5229:
5228:
5226:
5225:
5220:
5214:
5212:
5208:
5207:
5205:
5204:
5199:
5194:
5188:
5186:
5182:
5181:
5178:
5177:
5175:
5174:
5169:
5164:
5159:
5154:
5149:
5144:
5143:
5142:
5137:
5132:
5122:
5117:
5111:
5109:
5103:
5102:
5099:
5098:
5096:
5095:
5090:
5084:
5081:
5080:
5078:
5077:
5076:
5075:
5070:
5065:
5060:
5055:
5050:
5045:
5040:
5035:
5030:
5025:
5020:
5015:
5007:
5004:
5003:
5002:
4997:
4992:
4987:
4982:
4974:
4967:
4964:
4963:
4961:
4960:
4959:
4958:
4953:
4948:
4943:
4938:
4933:
4928:
4923:
4918:
4913:
4908:
4903:
4898:
4893:
4888:
4883:
4875:
4868:
4865:
4864:
4862:
4861:
4856:
4851:
4846:
4841:
4836:
4830:
4828:
4821:
4820:
4818:
4817:
4812:
4807:
4802:
4797:
4796:
4795:
4780:
4778:
4768:
4766:Heterotrimeric
4759:
4753:
4752:
4750:
4749:
4744:
4739:
4733:
4731:
4727:
4726:
4724:
4723:
4714:
4712:
4708:
4707:
4702:
4700:
4699:
4692:
4685:
4677:
4668:
4667:
4665:
4664:
4659:
4654:
4648:
4646:
4634:
4633:
4630:
4629:
4627:
4626:
4625:
4624:
4614:
4613:
4612:
4607:
4596:
4594:
4590:
4589:
4586:
4585:
4583:
4582:
4581:
4580:
4565:
4563:
4559:
4558:
4556:
4555:
4550:
4545:
4540:
4534:
4532:
4526:
4525:
4523:
4522:
4516:
4515:
4509:
4508:
4507:
4506:
4501:
4490:
4489:
4488:
4487:
4482:
4471:
4469:
4460:
4451:
4439:
4438:
4435:
4434:
4432:
4431:
4426:
4421:
4416:
4411:
4406:
4401:
4395:
4394:
4389:
4384:
4383:
4382:
4377:
4366:
4364:
4358:
4357:
4355:
4354:
4349:
4344:
4339:
4334:
4329:
4324:
4319:
4314:
4309:
4304:
4299:
4294:
4288:
4286:
4280:
4279:
4277:
4276:
4271:
4266:
4256:
4255:
4250:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4210:
4204:
4203:
4198:
4193:
4188:
4183:
4178:
4173:
4168:
4163:
4157:
4156:
4151:
4146:
4140:
4138:
4132:
4131:
4129:
4128:
4118:
4113:
4107:
4105:
4099:
4098:
4096:
4095:
4090:
4085:
4080:
4075:
4070:
4065:
4064:
4063:
4058:
4053:
4048:
4037:
4035:
4026:
4014:
4013:
3999:
3997:
3996:
3989:
3982:
3974:
3965:
3964:
3962:
3961:
3956:
3950:
3948:
3941:
3940:
3938:
3937:
3931:
3929:
3918:
3917:
3915:
3914:
3913:
3912:
3907:
3897:
3892:
3890:DCMP deaminase
3887:
3882:
3877:
3872:
3866:
3864:
3853:
3852:
3850:
3849:
3844:
3839:
3833:
3831:
3829:Ureohydrolases
3820:
3819:
3817:
3816:
3814:Dihydroorotase
3811:
3809:Beta-lactamase
3806:
3800:
3798:
3787:
3786:
3784:
3783:
3782:
3781:
3771:
3766:
3761:
3756:
3755:
3754:
3749:
3746:Aspartoacylase
3743:
3733:
3728:
3723:
3718:
3712:
3710:
3699:
3698:
3688:
3686:
3685:
3678:
3671:
3663:
3657:
3656:
3644:
3643:External links
3641:
3638:
3637:
3605:
3576:(3): 434–449.
3556:
3507:
3456:
3384:
3324:
3273:
3246:Molecular Cell
3232:
3180:
3121:
3072:
3020:
2985:
2956:(2): 107–115.
2936:
2887:
2838:
2789:
2748:
2713:
2649:
2618:(1): 145–169.
2598:
2569:(9): 3173–85.
2549:
2498:
2477:
2451:
2408:
2359:
2310:
2286:
2233:
2202:(2): 122–133.
2182:
2122:
2073:
2030:
2016:
1981:Molecular Cell
1962:
1905:
1848:
1827:(8): 1745–55.
1804:
1746:
1707:(23): 8563–8.
1676:
1675:
1673:
1670:
1669:
1668:
1666:Trichostatin A
1663:
1658:
1651:
1648:
1642:
1641:
1639:
1636:
1630:
1629:
1627:
1624:
1618:
1617:
1615:
1612:
1606:
1605:
1603:
1600:
1594:
1593:
1591:
1588:
1582:
1581:
1579:
1576:
1570:
1569:
1567:
1564:
1558:
1557:
1555:
1552:
1546:
1545:
1543:
1540:
1534:
1533:
1531:
1528:
1522:
1521:
1519:
1516:
1510:
1509:
1507:
1504:
1498:
1497:
1495:
1492:
1486:
1485:
1483:
1480:
1474:
1473:
1471:
1468:
1462:
1461:
1459:
1456:
1450:
1449:
1447:
1444:
1438:
1437:
1435:
1432:
1426:
1425:
1423:
1420:
1413:
1412:
1410:
1407:
1401:
1400:
1398:
1395:
1393:Beta-Lapachone
1389:
1388:
1386:
1383:
1377:
1376:
1374:
1371:
1365:
1364:
1362:
1359:
1353:
1352:
1349:
1346:
1333:
1330:
1321:
1318:
1264:
1261:
1240:
1239:
1232:
1230:
1149:
1147:
1140:
1134:
1131:
1114:
1111:
1104:
1103:
1101:
1099:
1097:
1095:
1092:
1089:
1087:
1085:
1083:
1081:
1078:
1076:
1072:
1071:
1069:
1067:
1065:
1063:
1060:
1055:Regulation of
1053:
1051:
1049:
1047:
1045:
1040:
1038:
1034:
1033:
1030:
1027:
1024:
1021:
1013:
1010:
1007:
1002:
999:
997:
995:
991:
990:
987:
984:
975:
972:
965:
962:
959:
954:
951:
949:
947:
944:
940:
939:
936:
933:
930:
927:
924:
921:
918:
913:
910:
908:
906:
904:
900:
899:
896:
893:
890:
887:
884:
881:
878:
873:
870:
868:
866:
864:
860:
859:
857:
855:
853:
851:
849:
847:
845:
843:
841:
836:
834:
830:
829:
826:
823:
817:
814:
811:
808:
805:
800:
797:
795:
792:
791:
788:
785:
776:
773:
770:
767:
764:
759:
756:
753:
751:
747:
746:
743:
740:
731:
728:
725:
722:
719:
714:
711:
706:
704:
701:
697:
696:
693:
690:
687:
683:
682:
677:
672:
667:
662:
659:
656:
651:
648:
645:
608:
607:
522:
520:
513:
507:
504:
491:
488:
474:
471:
450:, which is an
358:depalmitoylase
318:
317:
314:
313:
209:
203:
202:
197:
191:
190:
177:
171:
170:
160:
153:
152:
144:
143:
130:
124:
123:
118:
112:
111:
106:
100:
99:
94:
87:
86:
81:
75:
74:
71:
67:
66:
62:
61:
34:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
5764:
5753:
5750:
5748:
5745:
5743:
5740:
5739:
5737:
5724:
5723:
5716:
5710:
5707:
5705:
5702:
5700:
5697:
5695:
5692:
5690:
5687:
5685:
5682:
5680:
5677:
5675:
5672:
5671:
5669:
5665:
5659:
5658:
5653:
5652:
5650:
5648:
5644:
5638:
5637:
5632:
5631:
5629:
5627:
5623:
5613:
5610:
5609:
5607:
5603:
5597:
5594:
5592:
5588:
5585:
5584:
5582:
5579:
5575:
5569:
5566:
5565:
5563:
5560:
5556:
5553:
5551:
5546:
5536:
5533:
5531:
5528:
5527:
5525:
5521:
5513:
5510:
5508:
5505:
5503:
5500:
5498:
5495:
5493:
5490:
5489:
5488:
5485:
5484:
5482:
5478:
5472:
5469:
5465:
5462:
5460:
5457:
5456:
5455:
5452:
5450:
5447:
5446:
5444:
5441:
5437:
5429:
5426:
5425:
5424:
5421:
5417:
5414:
5412:
5409:
5408:
5407:
5404:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5381:
5380:
5377:
5373:
5370:
5368:
5365:
5364:
5363:
5360:
5356:
5353:
5351:
5348:
5346:
5343:
5341:
5338:
5337:
5336:
5333:
5329:
5326:
5324:
5321:
5319:
5316:
5315:
5314:
5311:
5307:
5304:
5302:
5299:
5297:
5294:
5292:
5289:
5287:
5284:
5283:
5282:
5279:
5275:
5272:
5271:
5270:
5267:
5263:
5260:
5258:
5255:
5254:
5253:
5252:Casein kinase
5250:
5249:
5247:
5244:
5240:
5237:
5235:
5230:
5224:
5221:
5219:
5216:
5215:
5213:
5209:
5203:
5200:
5198:
5195:
5193:
5190:
5189:
5187:
5183:
5173:
5170:
5168:
5165:
5163:
5160:
5158:
5155:
5153:
5150:
5148:
5145:
5141:
5138:
5136:
5133:
5131:
5128:
5127:
5126:
5123:
5121:
5118:
5116:
5113:
5112:
5110:
5108:
5104:
5094:
5091:
5089:
5086:
5085:
5082:
5074:
5071:
5069:
5066:
5064:
5061:
5059:
5056:
5054:
5051:
5049:
5046:
5044:
5041:
5039:
5036:
5034:
5031:
5029:
5026:
5024:
5021:
5019:
5016:
5014:
5011:
5010:
5005:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4981:
4978:
4977:
4972:
4969:
4968:
4965:
4957:
4954:
4952:
4949:
4947:
4944:
4942:
4939:
4937:
4934:
4932:
4929:
4927:
4924:
4922:
4919:
4917:
4914:
4912:
4909:
4907:
4904:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4882:
4879:
4878:
4873:
4870:
4869:
4866:
4860:
4857:
4855:
4852:
4850:
4847:
4845:
4842:
4840:
4837:
4835:
4832:
4831:
4829:
4826:
4822:
4816:
4813:
4811:
4808:
4806:
4803:
4801:
4798:
4794:
4790:
4787:
4786:
4785:
4782:
4781:
4779:
4776:
4772:
4769:
4767:
4763:
4760:
4758:
4754:
4748:
4745:
4743:
4740:
4738:
4735:
4734:
4732:
4728:
4722:
4721:
4716:
4715:
4713:
4709:
4705:
4698:
4693:
4691:
4686:
4684:
4679:
4678:
4675:
4663:
4660:
4658:
4655:
4653:
4650:
4649:
4647:
4645:
4639:
4635:
4623:
4620:
4619:
4618:
4615:
4611:
4608:
4606:
4603:
4602:
4601:
4598:
4597:
4595:
4591:
4579:
4576:
4575:
4574:
4570:
4567:
4566:
4564:
4560:
4554:
4551:
4549:
4546:
4544:
4541:
4539:
4536:
4535:
4533:
4531:
4527:
4521:
4518:
4517:
4514:
4511:
4510:
4505:
4504:Cholera toxin
4502:
4500:
4497:
4496:
4495:
4492:
4491:
4486:
4483:
4481:
4478:
4477:
4476:
4473:
4472:
4470:
4468:
4464:
4461:
4459:
4455:
4452:
4450:
4444:
4440:
4430:
4427:
4425:
4422:
4420:
4417:
4415:
4412:
4410:
4407:
4405:
4402:
4400:
4397:
4396:
4393:
4390:
4388:
4385:
4381:
4378:
4376:
4373:
4372:
4371:
4368:
4367:
4365:
4363:
4359:
4353:
4350:
4348:
4345:
4343:
4340:
4338:
4335:
4333:
4330:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4289:
4287:
4285:
4281:
4275:
4272:
4270:
4267:
4265:
4261:
4258:
4257:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4229:
4226:
4224:
4221:
4219:
4216:
4214:
4211:
4209:
4206:
4205:
4202:
4199:
4197:
4194:
4192:
4189:
4187:
4184:
4182:
4179:
4177:
4174:
4172:
4169:
4167:
4164:
4162:
4159:
4158:
4155:
4152:
4150:
4147:
4145:
4142:
4141:
4139:
4137:
4136:Glucuronosyl-
4133:
4126:
4122:
4119:
4117:
4114:
4112:
4109:
4108:
4106:
4104:
4100:
4094:
4091:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4043:
4042:
4041:Phosphorylase
4039:
4038:
4036:
4034:
4030:
4027:
4025:
4019:
4015:
4010:
4006:
4002:
3995:
3990:
3988:
3983:
3981:
3976:
3975:
3972:
3960:
3959:Thiaminase II
3957:
3955:
3954:Riboflavinase
3952:
3951:
3949:
3946:
3942:
3936:
3933:
3932:
3930:
3928:
3923:
3919:
3911:
3908:
3906:
3903:
3902:
3901:
3898:
3896:
3893:
3891:
3888:
3886:
3883:
3881:
3880:AMP deaminase
3878:
3876:
3873:
3871:
3868:
3867:
3865:
3863:
3858:
3854:
3848:
3845:
3843:
3840:
3838:
3835:
3834:
3832:
3830:
3825:
3821:
3815:
3812:
3810:
3807:
3805:
3802:
3801:
3799:
3797:
3792:
3788:
3780:
3777:
3776:
3775:
3772:
3770:
3767:
3765:
3762:
3760:
3757:
3753:
3750:
3747:
3744:
3742:
3739:
3738:
3737:
3734:
3732:
3729:
3727:
3724:
3722:
3719:
3717:
3714:
3713:
3711:
3709:
3704:
3700:
3695:
3691:
3684:
3679:
3677:
3672:
3670:
3665:
3664:
3661:
3654:
3650:
3647:
3646:
3642:
3633:
3632:
3624:
3622:
3620:
3618:
3616:
3614:
3612:
3610:
3606:
3601:
3597:
3592:
3587:
3583:
3579:
3575:
3571:
3567:
3560:
3557:
3552:
3548:
3543:
3538:
3534:
3530:
3526:
3522:
3518:
3511:
3508:
3503:
3499:
3494:
3489:
3484:
3479:
3475:
3471:
3467:
3460:
3457:
3452:
3448:
3443:
3438:
3434:
3430:
3426:
3422:
3418:
3414:
3410:
3403:
3401:
3399:
3397:
3395:
3393:
3391:
3389:
3385:
3380:
3376:
3371:
3366:
3361:
3356:
3352:
3348:
3344:
3337:
3335:
3333:
3331:
3329:
3325:
3320:
3316:
3311:
3306:
3301:
3296:
3292:
3288:
3284:
3277:
3274:
3269:
3265:
3260:
3255:
3252:(6): 855–68.
3251:
3247:
3243:
3236:
3233:
3228:
3224:
3219:
3214:
3210:
3206:
3202:
3198:
3194:
3187:
3185:
3181:
3176:
3172:
3167:
3162:
3157:
3152:
3148:
3144:
3140:
3136:
3132:
3125:
3122:
3117:
3113:
3108:
3103:
3099:
3095:
3092:(1): 109–21.
3091:
3087:
3083:
3076:
3073:
3068:
3064:
3060:
3056:
3051:
3046:
3043:(2): 315–29.
3042:
3038:
3034:
3027:
3025:
3021:
3016:
3012:
3008:
3004:
3001:(4): 383–93.
3000:
2996:
2989:
2986:
2981:
2977:
2972:
2967:
2963:
2959:
2955:
2951:
2947:
2940:
2937:
2932:
2928:
2923:
2918:
2914:
2910:
2906:
2902:
2898:
2891:
2888:
2883:
2879:
2875:
2871:
2866:
2861:
2858:(2): e29-46.
2857:
2853:
2849:
2842:
2839:
2834:
2830:
2825:
2820:
2816:
2812:
2808:
2804:
2800:
2793:
2790:
2785:
2781:
2776:
2771:
2768:(2): 104–12.
2767:
2763:
2759:
2752:
2749:
2744:
2740:
2736:
2732:
2729:(3): 731–41.
2728:
2724:
2717:
2714:
2709:
2705:
2700:
2695:
2691:
2687:
2682:
2677:
2673:
2669:
2665:
2658:
2656:
2654:
2650:
2645:
2641:
2636:
2631:
2626:
2621:
2617:
2613:
2609:
2602:
2599:
2594:
2590:
2585:
2580:
2576:
2572:
2568:
2564:
2560:
2553:
2550:
2545:
2541:
2537:
2533:
2529:
2525:
2521:
2517:
2513:
2509:
2502:
2499:
2487:
2481:
2478:
2466:
2462:
2455:
2452:
2447:
2443:
2439:
2435:
2431:
2427:
2424:(1): 417–35.
2423:
2419:
2412:
2409:
2404:
2400:
2395:
2390:
2386:
2382:
2378:
2374:
2370:
2363:
2360:
2355:
2351:
2346:
2341:
2337:
2333:
2329:
2325:
2321:
2314:
2311:
2300:
2296:
2290:
2287:
2282:
2278:
2273:
2268:
2263:
2258:
2254:
2250:
2249:
2244:
2237:
2234:
2228:
2223:
2219:
2215:
2210:
2205:
2201:
2197:
2193:
2186:
2183:
2178:
2174:
2169:
2164:
2160:
2156:
2152:
2148:
2144:
2140:
2136:
2129:
2127:
2123:
2118:
2114:
2109:
2104:
2100:
2096:
2092:
2088:
2084:
2077:
2074:
2069:
2065:
2061:
2057:
2053:
2049:
2046:(5): 669–80.
2045:
2041:
2034:
2031:
2028:
2025:
2020:
2017:
2012:
2008:
2003:
1998:
1994:
1990:
1987:(2): 309–20.
1986:
1982:
1978:
1971:
1969:
1967:
1963:
1958:
1954:
1949:
1944:
1940:
1936:
1932:
1928:
1924:
1920:
1916:
1909:
1906:
1901:
1897:
1892:
1887:
1883:
1879:
1875:
1871:
1867:
1863:
1859:
1852:
1849:
1844:
1840:
1835:
1830:
1826:
1822:
1818:
1811:
1809:
1805:
1800:
1796:
1791:
1786:
1782:
1778:
1774:
1770:
1766:
1759:
1757:
1755:
1753:
1751:
1747:
1742:
1738:
1733:
1728:
1723:
1718:
1714:
1710:
1706:
1702:
1698:
1691:
1687:
1681:
1678:
1671:
1667:
1664:
1662:
1659:
1657:
1654:
1653:
1649:
1647:
1640:
1637:
1635:
1632:
1631:
1628:
1625:
1623:
1622:Pterostilbene
1620:
1619:
1616:
1613:
1611:
1608:
1607:
1604:
1601:
1599:
1596:
1595:
1592:
1589:
1587:
1584:
1583:
1580:
1577:
1575:
1572:
1571:
1568:
1565:
1563:
1560:
1559:
1556:
1553:
1551:
1548:
1547:
1544:
1541:
1539:
1536:
1535:
1532:
1529:
1527:
1524:
1523:
1520:
1517:
1515:
1512:
1511:
1508:
1505:
1503:
1500:
1499:
1496:
1493:
1491:
1488:
1487:
1484:
1481:
1479:
1476:
1475:
1472:
1469:
1467:
1464:
1463:
1460:
1457:
1455:
1454:Phenolic acid
1452:
1451:
1448:
1445:
1443:
1440:
1439:
1436:
1433:
1431:
1428:
1427:
1424:
1421:
1418:
1415:
1414:
1411:
1408:
1406:
1403:
1402:
1399:
1396:
1394:
1391:
1390:
1387:
1384:
1382:
1379:
1378:
1375:
1372:
1370:
1367:
1366:
1363:
1360:
1358:
1355:
1354:
1350:
1347:
1344:
1343:
1340:
1331:
1329:
1327:
1319:
1317:
1315:
1311:
1306:
1304:
1300:
1296:
1291:
1289:
1285:
1281:
1277:
1273:
1269:
1262:
1260:
1258:
1255:
1251:
1247:
1231:
1227:
1224:November 2019
1216:
1213:
1209:
1206:
1202:
1199:
1195:
1192:
1188:
1185: –
1184:
1180:
1179:Find sources:
1174:
1170:
1164:
1163:
1159:
1155:
1150:This section
1148:
1139:
1138:
1132:
1130:
1128:
1124:
1120:
1112:
1110:
1102:
1100:
1098:
1096:
1093:
1090:
1088:
1086:
1084:
1082:
1079:
1077:
1074:
1073:
1070:
1068:
1066:
1064:
1061:
1058:
1054:
1052:
1050:
1048:
1046:
1044:
1041:
1039:
1036:
1035:
1031:
1028:
1025:
1022:
1020:
1019:transcription
1017:
1014:
1011:
1008:
1006:
1003:
1000:
998:
996:
993:
992:
988:
985:
983:
979:
976:
973:
970:
966:
963:
960:
958:
955:
952:
950:
948:
945:
941:
937:
934:
931:
928:
925:
922:
919:
917:
914:
911:
909:
907:
905:
902:
901:
897:
894:
891:
888:
885:
882:
879:
877:
874:
871:
869:
867:
865:
862:
861:
858:
856:
854:
852:
850:
848:
846:
844:
842:
837:
835:
832:
831:
827:
824:
821:
818:
815:
812:
809:
806:
804:
801:
798:
796:
794:
793:
789:
786:
784:
780:
777:
774:
771:
768:
765:
763:
760:
757:
754:
752:
748:
744:
741:
739:
735:
732:
729:
726:
723:
720:
718:
715:
712:
707:
705:
702:
698:
694:
691:
688:
685:
684:
681:
676:
671:
666:
653:Intracellular
642:
636:
634:
630:
629:
624:
623:
618:
617:
604:
601:
593:
590:November 2019
582:
579:
575:
572:
568:
565:
561:
558:
554:
551: –
550:
546:
545:Find sources:
539:
535:
529:
528:
523:This section
521:
517:
512:
511:
505:
503:
501:
497:
489:
487:
484:
480:
472:
470:
468:
464:
459:
457:
453:
449:
445:
441:
437:
436:deacetylation
434:
430:
426:
423:
419:
414:
412:
408:
404:
400:
396:
395:transcription
392:
388:
387:
381:
379:
375:
371:
367:
363:
359:
355:
351:
350:desuccinylase
347:
343:
339:
335:
331:
328:
324:
310:
304:
298:
292:
286:
280:
274:
268:
262:
256:
250:
244:
238:
232:
226:
220:
214:
210:
208:
204:
201:
198:
196:
192:
189:
185:
181:
178:
176:
172:
168:
164:
161:
158:
154:
149:
145:
142:
138:
134:
131:
129:
125:
122:
119:
117:
113:
110:
107:
105:
101:
98:
95:
92:
88:
85:
82:
80:
76:
72:
68:
63:
58:
54:
50:
46:
42:
38:
32:
27:
22:
19:
5719:
5654:
5633:
5269:eIF-2 kinase
4717:
4644:transferases
4519:
4449:transferases
4024:transferases
4001:Transferases
3778:
3736:Aminoacylase
3716:Asparaginase
3630:
3573:
3569:
3559:
3524:
3520:
3510:
3473:
3470:Marine Drugs
3469:
3459:
3416:
3412:
3350:
3346:
3290:
3286:
3276:
3249:
3245:
3235:
3200:
3196:
3138:
3134:
3124:
3089:
3085:
3075:
3040:
3036:
2998:
2994:
2988:
2953:
2949:
2939:
2904:
2900:
2890:
2855:
2851:
2841:
2806:
2802:
2792:
2765:
2761:
2751:
2726:
2722:
2716:
2671:
2667:
2615:
2611:
2601:
2566:
2562:
2552:
2511:
2507:
2501:
2490:. Retrieved
2480:
2469:. Retrieved
2464:
2454:
2421:
2417:
2411:
2379:(4): 600–8.
2376:
2372:
2362:
2327:
2323:
2313:
2302:. Retrieved
2298:
2289:
2252:
2246:
2236:
2199:
2195:
2185:
2142:
2138:
2090:
2086:
2076:
2043:
2039:
2033:
2019:
1984:
1980:
1922:
1918:
1908:
1865:
1861:
1851:
1824:
1820:
1772:
1768:
1704:
1700:
1680:
1645:
1574:Ferulic acid
1482:SIRT1, SIRT6
1338:
1326:nicotinamide
1323:
1307:
1292:
1266:
1243:
1221:
1211:
1204:
1197:
1190:
1178:
1158:verification
1151:
1116:
1107:
920:Mitochondria
880:Mitochondria
807:Mitochondria
679:
674:
669:
664:
626:
620:
614:
611:
596:
587:
577:
570:
563:
556:
544:
532:Please help
527:verification
524:
493:
476:
460:
448:nicotinamide
415:
403:inflammation
384:
382:
373:
369:
365:
361:
354:demalonylase
332:involved in
322:
321:
18:
4956:GNA15/GNA16
4742:Calcineurin
4103:Galactosyl-
3924:: Nitriles/
3804:Barbiturase
3731:Biotinidase
3721:Glutaminase
3419:(1): 4163.
2299:www.nmn.com
1526:Delphinidin
1490:Pirfenidone
1357:Piceatannol
1351:References
1293:SIRT6 is a
1246:scleroderma
1152:needs more
1119:resveratrol
1062:metabolism
1012:Deacetylase
813:Metabolism
810:Deacetylase
769:Deacetylase
736:, H1K26ac,
724:Deacetylase
633:macrodomain
368:nformation
65:Identifiers
24:Sir2 family
5736:Categories
5362:Lim kinase
5313:IκB kinase
4834:Transducin
4056:Cellobiose
3842:Agmatinase
3759:Ceramidase
3690:Hydrolases
3521:Oncotarget
3476:(6): 190.
3353:: 585821.
2995:DNA Repair
2492:2008-11-30
2471:2008-11-30
2304:2021-01-04
2024:EntrezGene
1771:(Review).
1769:Oncotarget
1672:References
1405:Cilostazol
1332:Activators
1320:Inhibitors
1303:DNA damage
1280:DNA repair
1194:newspapers
1059:synthetase
1057:acetyl-CoA
971:secretion
822:, H4K14ac
560:newspapers
372:egulation
163:structures
57:histone H4
45:C-terminus
41:N-terminus
5720:see also
5626:Apoptosis
5107:Monomeric
4839:Gustducin
4757:G protein
4447:Pentosyl-
4362:Mannosyl-
4033:Glucosyl-
3935:Nitrilase
2907:(4): 16.
2809:: 24–32.
2690:1868-7075
2218:2755-0230
2159:2152-5250
1693:;
1586:Berberine
1502:Myricetin
1417:Quercetin
1295:chromatin
1183:"Sirtuin"
1009:Nucleolus
895:GDH, PDH
680:Pathology
658:Activity
655:location
647:Subclass
549:"Sirtuin"
452:inhibitor
422:hydrolyze
399:apoptosis
346:deacylase
327:signaling
306:,
300:,
294:,
288:,
282:,
276:,
270:,
264:,
258:,
252:,
246:,
240:,
234:,
228:,
222:,
216:,
109:IPR003000
5578:Tyrosine
5523:Arginine
5440:Tyrosine
4284:Fucosyl-
4051:Glycogen
4022:Hexosyl-
3837:Arginase
3649:Sirtuins
3600:32140659
3551:27034011
3502:28635654
3451:29515203
3379:33597872
3319:28417163
3310:11107671
3268:15780941
3227:27225932
3175:22753495
3116:20157594
3067:18517518
3059:16439206
3015:20097625
2980:28406750
2931:29550994
2882:12847291
2874:26771470
2833:25005742
2784:18249170
2743:15019790
2708:27226812
2644:31437090
2593:12697818
2536:10693811
2446:27494475
2438:15189148
2403:19459166
2354:30534609
2281:32518153
2227:10081735
2177:30574426
2117:20668205
2060:23325925
2011:26166706
1957:23552949
1900:22076378
1843:17456799
1799:27659520
1741:15150415
1650:See also
1610:Malvidin
1598:Catechin
1538:Apigenin
1514:Cyanidin
1478:Curcumin
1466:Fucoidan
1430:Luteolin
1381:SRT-2104
1369:SRT-1720
1345:Compound
1339:in vitro
1290:breaks.
1250:fibrosis
1026:H3K18ac
986:Unknown
932:Unknown
892:Unknown
686:Bacteria
650:Species
467:cofactor
386:in vitro
330:proteins
323:Sirtuins
180:RCSB PDB
104:InterPro
43:= blue,
5742:Enzymes
5704:EDARADD
5689:Mucin-4
5428:RPS6KA1
5274:EIF2AK3
4730:Calcium
4662:ST8SIA4
4520:Sirtuin
4253:UGT2B28
4248:UGT2B17
4243:UGT2B15
4238:UGT2B11
4233:UGT2B10
4201:UGT1A10
4125:C1GALT1
3947:: Other
3779:Sirtuin
3591:7049672
3542:4991376
3493:5484140
3442:5841289
3421:Bibcode
3370:7883599
3218:4884211
3166:3406824
3143:Bibcode
3107:2815768
2971:5403131
2950:Nucleus
2922:5942182
2824:4254145
2699:4879741
2635:7002868
2544:2967911
2516:Bibcode
2394:2766855
2345:6281622
2330:: 217.
2272:7415977
2168:6284760
2108:2922851
2068:3070941
2002:4518038
1948:3635073
1927:Bibcode
1891:3217313
1870:Bibcode
1862:Science
1790:5352102
1709:Bibcode
1634:Tyrosol
1442:Fisetin
1208:scholar
1173:removed
982:H3K56ac
961:Nucleus
820:H3K56ac
783:H4K16ac
779:H3K56ac
738:H4K16ac
574:scholar
490:History
312:
121:PS50305
116:PROSITE
84:PF02146
5709:PRKCSH
5548:Other
5497:DYRK1B
5492:DYRK1A
5232:Other
5202:Cyclin
5185:Cyclin
4642:Sialyl
4638:2.4.99
4458:Ribose
4297:POFUT2
4292:POFUT1
4228:UGT2B7
4223:UGT2B4
4218:UGT2A3
4213:UGT2A2
4208:UGT2A1
4196:UGT1A9
4191:UGT1A8
4186:UGT1A7
4181:UGT1A6
4176:UGT1A5
4171:UGT1A4
4166:UGT1A3
4161:UGT1A1
4154:B3GAT3
4149:B3GAT2
4144:B3GAT1
4046:Starch
3945:3.5.99
3748:(ACY2)
3726:Urease
3655:(MeSH)
3598:
3588:
3549:
3539:
3500:
3490:
3449:
3439:
3377:
3367:
3317:
3307:
3266:
3225:
3215:
3173:
3163:
3114:
3104:
3065:
3057:
3013:
2978:
2968:
2929:
2919:
2880:
2872:
2831:
2821:
2782:
2741:
2706:
2696:
2688:
2674:: 61.
2642:
2632:
2591:
2584:153197
2581:
2542:
2534:
2508:Nature
2444:
2436:
2401:
2391:
2352:
2342:
2279:
2269:
2224:
2216:
2175:
2165:
2157:
2115:
2105:
2066:
2058:
2009:
1999:
1955:
1945:
1919:Nature
1898:
1888:
1841:
1797:
1787:
1739:
1732:423234
1729:
1550:Butein
1210:
1203:
1196:
1189:
1181:
1113:Ageing
1080:SirTM
978:H3K9ac
734:H3K9ac
695:Human
644:Class
576:
569:
562:
555:
547:
444:ribose
433:lysine
429:lysine
425:acetyl
195:PDBsum
169:
159:
141:SUPFAM
97:CL0085
70:Symbol
16:Enzyme
5667:Other
5605:both:
5512:DYRK4
5507:DYRK3
5502:DYRK2
5464:PTK2B
5449:ZAP70
5416:ROCK2
5411:ROCK1
5372:LIMK2
5367:LIMK1
5355:IRAK4
5350:IRAK3
5345:IRAK2
5340:IRAK1
5328:IKBKG
5306:GSK3B
5301:GSK3A
5296:GSK-3
5211:Lipid
5162:Rhebs
5073:BSCL2
5068:GNG13
5063:GNG12
5058:GNG11
5053:GNG10
5018:GNGT2
5013:GNGT1
4951:GNA14
4946:GNA13
4941:GNA12
4936:GNA11
4911:GNAT3
4906:GNAT2
4901:GNAT1
4896:GNAI3
4891:GNAI2
4886:GNAI1
4881:GNAO1
4610:XYLT2
4605:XYLT1
4593:Other
4578:ECGF1
4562:Other
4443:2.4.2
4429:ALG12
4380:POMT2
4375:POMT1
4352:FUT11
4347:FUT10
4018:2.4.1
3922:3.5.5
3905:AICDA
3857:3.5.4
3824:3.5.3
3791:3.5.2
3703:3.5.1
3086:Aging
3063:S2CID
2878:S2CID
2540:S2CID
2442:S2CID
2064:S2CID
2027:23410
1638:SIRT1
1626:SIRT1
1614:SIRT1
1602:SIRT1
1590:SIRT1
1578:SIRT1
1566:SIRT6
1554:SIRT6
1542:SIRT6
1530:SIRT6
1518:SIRT6
1506:SIRT6
1494:SIRT1
1470:SIRT6
1458:SIRT6
1446:SIRT6
1434:SIRT6
1422:SIRT6
1409:SIRT1
1397:SIRT1
1385:SIRT1
1373:SIRT1
1361:SIRT1
1276:SIRT7
1272:SIRT6
1268:SIRT1
1254:TGF-β
1215:JSTOR
1201:books
1123:SIRT1
1005:SIRT7
1001:Sirt7
957:SIRT6
953:Sirt6
935:CPS1
916:SIRT5
912:Sirt5
876:SIRT4
872:Sirt4
838:Hst3,
803:SIRT3
799:Sirt3
762:SIRT2
758:Sirt2
717:SIRT1
713:Sirt1
708:Sir2,
692:Mouse
689:Yeast
581:JSTOR
567:books
506:Types
391:aging
383:From
378:yeast
137:SCOPe
128:SCOP2
5655:see
5634:see
5535:McsB
5459:PTK2
5399:PAK4
5394:PAK3
5389:PAK2
5384:PAK1
5323:IKK2
5318:CHUK
5291:GSK2
5286:GSK1
5172:RGKs
5167:Raps
5152:Arfs
5147:Rhos
5140:NRAS
5135:KRAS
5130:HRAS
5120:Rabs
5115:ARFs
5048:GNG8
5043:GNG7
5038:GNG5
5033:GNG4
5028:GNG3
5023:GNG2
5000:GNB5
4995:GNB4
4990:GNB3
4985:GNB2
4980:GNB1
4931:GNAQ
4926:GNAL
4921:GNAS
4916:GNAZ
4849:cGMP
4825:cGMP
4805:cAMP
4775:cAMP
4718:see
4424:ALG9
4419:ALG8
4414:ALG6
4409:ALG3
4404:ALG2
4399:ALG1
4392:DPM3
4387:DPM1
4342:FUT9
4337:FUT8
4332:FUT7
4327:FUT6
4322:FUT5
4317:FUT4
4312:FUT3
4307:FUT2
4302:FUT1
4274:HAS3
4269:HAS2
4264:HAS1
4061:Myo-
4011:2.4)
3752:ACY3
3741:ACY1
3696:3.5)
3596:PMID
3547:PMID
3498:PMID
3447:PMID
3375:PMID
3315:PMID
3264:PMID
3223:PMID
3171:PMID
3112:PMID
3055:PMID
3037:Cell
3011:PMID
2976:PMID
2927:PMID
2870:PMID
2829:PMID
2780:PMID
2739:PMID
2704:PMID
2686:ISSN
2640:PMID
2589:PMID
2532:PMID
2434:PMID
2399:PMID
2350:PMID
2277:PMID
2214:ISSN
2173:PMID
2155:ISSN
2113:PMID
2056:PMID
2007:PMID
1953:PMID
1896:PMID
1839:PMID
1795:PMID
1737:PMID
1690:1szd
1274:and
1187:news
1156:for
1043:cobB
1016:rRNA
840:Hst4
755:Hst2
710:Hst1
625:and
553:news
483:sir2
309:1yc5
303:1yc2
297:1szd
291:1szc
285:1s7g
279:1s5p
273:1q1a
267:1q17
261:1q14
255:1ma3
249:1m2n
243:1m2k
237:1m2j
231:1m2h
225:1m2g
219:1j8f
213:1ici
188:PDBj
184:PDBe
167:ECOD
157:Pfam
133:1j8f
93:clan
91:Pfam
79:Pfam
73:SIR2
37:sir2
5471:BTK
5157:Ran
5125:Ras
4711:MAP
3586:PMC
3578:doi
3537:PMC
3529:doi
3488:PMC
3478:doi
3437:PMC
3429:doi
3365:PMC
3355:doi
3305:PMC
3295:doi
3254:doi
3213:PMC
3205:doi
3161:PMC
3151:doi
3139:109
3102:PMC
3094:doi
3045:doi
3041:124
3003:doi
2966:PMC
2958:doi
2917:PMC
2909:doi
2860:doi
2856:103
2819:PMC
2811:doi
2770:doi
2731:doi
2727:337
2694:PMC
2676:doi
2630:PMC
2620:doi
2616:100
2579:PMC
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