1709:
2102:
28:
2114:
752:
Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, Kametani F, Garringer HJ, Vidal R, Hallinan GI, Lashley T, Saito Y, Murayama S, Yoshida M, Tanaka H, Kakita A, Ikeuchi T, Robinson AC, Mann DM, Kovacs GG, Revesz T, Ghetti B, Hasegawa M, Goedert M, Scheres SH (2021).
925:
Schweighauser M, Arseni D, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van
Swieten J, Takao M, Hasegawa M, Ghetti B, Falcon B, Murzin AG,
580:
Nakane T, Kotecha A, Sente A, McMullan G, Masiulis S, Brown PM, Grigoras IT, Malinauskaite L, Malinauskas T, Miehling J, Uchanski T, Yu L, Karia D, Pechnikova EV, de Jong E, Keizer J, Bischoff M, McCormack J, Tiemeijer P, Hardwick SW, Chirgadze DY, Murshudov G, Aricescu AR, Scheres SH (2020).
810:
Yang Y, Arseni D, Zhang W, Huang M, Lovestam S, Schweighauser M, Kotecha A, Murzin AG, Peak-Chew SY, Macdonald J, Lavenir I, Garringer HJ, Gelpi E, Newell KL, Kovacs GG, Vidal R, Ghetti B, Falcon B, Scheres SH, Goedert M (2022).
2160:
1979:
1974:
2155:
242:
Besides developing algorithms for cryo-EM image processing, Scheres has also collaborated with experimental groups to solve important protein structures. For example, Xiaochen Bai, currently at
235:
determination by cryo-EM, which he implemented in the computer program RELION. In 2020, Scheres and collaborators used RELION to reach atomic resolution for a cryo-EM reconstruction of apo-
2030:
439:
Scheres SH, Gao H, Valle M, Herman GT, Eggermont PP, Frank J, Carazo JM (2007). "Disentangling
Conformational States of Macromolecules in 3D-EM through Likelihood Optimization".
868:
Schweighauser M, Shi Y, Tarutani A, Kametani F, Murzin AG, Ghetti B, Matsubara T, Tomita T, Ando T, Hasegawa K, Murayama S, Yoshida M, Hasegawa M, Scheres SH, Goedert M (2020).
2170:
212:
77:
314:
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423:
98:
2035:
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337:
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2025:
2017:
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1308:
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1941:
1911:
1840:
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1989:
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1462:
1823:
398:
2150:
1901:
1127:
695:
Fitzpatrick AW, Falcon B, He S, Murzin AG, Murshudov G, Garringer HJ, Crowther RA, Ghetti B, Goedert M, Scheres SH (2017).
1916:
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1211:
220:
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1688:
2040:
1313:
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1592:
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1241:
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1708:
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1351:
1341:
983:
1477:
2106:
1830:
1726:
1599:
1562:
1356:
1336:
1204:
274:. Since then, Scheres and Goedert have also solved the cryo-EM structures of tau filaments from multiple other
1514:
1077:
1954:
1798:
1743:
1492:
1457:
291:
208:
192:
1650:
2145:
1467:
283:
271:
228:
1572:
2007:
1803:
1765:
1524:
1258:
1102:
262:. Using cryo-EM image processing methods that were developed by Scheres, they solved the structure of
2140:
1731:
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1440:
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1164:
939:
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82:
49:
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1007:
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232:
1969:
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110:
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1168:
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828:
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598:
215:
with José Maria Carazo from 2003-2010, where he developed classification algorithms for
1668:
1633:
1621:
1616:
1582:
1552:
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1501:
1445:
1369:
1323:
1031:
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2134:
1813:
1626:
1425:
330:
468:
1519:
1509:
1403:
1286:
279:
1078:"Sjors Scheres is awarded the Bijvoet Medal - MRC Laboratory of Molecular Biology"
533:"RELION: implementation of a Bayesian approach to cryo-EM structure determination"
425:
Conditional
Optimization: An N-particle formalism for protein structure refinement
2002:
1673:
1547:
1374:
1103:"Sjors Scheres elected to EMBO membership - MRC Laboratory of Molecular Biology"
344:
305:
since 2014. He has been joint Head of the
Division of Structural Studies of the
267:
99:
Conditional
Optimization: an N-particle approach to protein structure refinement
951:
778:
1567:
1253:
893:
606:
548:
499:
251:
1276:
836:
638:
Bai XC, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SH, Shi Y (2015).
275:
227:, Cambridge. There, he extended his maximum-likelihood methods to a general
196:
115:
1186:
969:
911:
854:
796:
738:
681:
624:
566:
517:
460:
27:
1873:
1643:
1391:
295:
236:
720:
663:
1883:
1055:
928:"Age-dependent formation of TMEM106B amyloid filaments in human brain"
870:"Structures of alpha-synuclein filaments from multiple system atrophy"
183:
in France for his undergraduate research thesis. He then came back to
452:
92:
1177:
1152:
1878:
1196:
813:"Cryo-EM Structures of Amyloid-beta 42 Filaments from Human Brain"
302:
301:
Scheres has been a member of the Board of
Reviewing Editors for
243:
1200:
697:"Cryo-EM structures of tau filaments from Alzheimer's disease"
2161:
Members of the Royal
Netherlands Academy of Arts and Sciences
1058:(in Dutch). Royal Netherlands Academy of Arts and Sciences
1980:
1008:"Structural Studies - MRC Laboratory of Molecular Biolog"
984:"Editors for Structural Biology and Molecular Biophysics"
223:. In 2010 Scheres was appointed as a group leader at the
1975:
254:. Since 2016, Scheres has worked closely together with
2156:
Members of the
European Molecular Biology Organization
1868:
399:"Sjors Scheres - MRC Laboratory of Molecular Biology"
484:"A Bayesian view on cryo-EM structure determination"
2049:
2016:
1988:
1940:
1892:
1839:
1786:
1717:
1500:
1491:
1414:
1322:
1267:
1234:
125:
109:
91:
65:
42:
34:
18:
313:. In 2022, he was elected a foreign member of the
179:in The Netherlands, and spent nine months at the
755:"Structure-based classification of tauopathies"
213:Spanish National Center for Biotechnology (CNB)
78:Spanish National Center for Biotechnology (CNB)
640:"An atomic structure of human gamma-secretase"
583:"Single-particle cryo-EM at atomic resolution"
315:Royal Netherlands Academy of Arts and Sciences
1212:
1128:"Winners KNCV Gouden Medaille - KNCV English"
246:, in his group solved the structure of human
8:
2046:
1497:
1319:
1264:
1219:
1205:
1197:
375:"Sjors Scheres - Google Scholar Citations"
26:
15:
1176:
959:
901:
844:
786:
728:
671:
614:
556:
507:
338:Bijvoet Center for Biomolecular Research
163:(born 1975) is a Dutch scientist at the
2171:Dutch expatriates in the United Kingdom
366:
181:European Synchrotron Radiation Facility
309:since 2018. In 2021, he was elected a
270:from the brain of an individual with
7:
2113:
1453:Phase transformation crystallography
1960:Journal of Chemical Crystallography
1107:MRC Laboratory of Molecular Biology
1082:MRC Laboratory of Molecular Biology
403:MRC Laboratory of Molecular Biology
307:MRC Laboratory of Molecular Biology
260:MRC Laboratory of Molecular Biology
225:MRC Laboratory of Molecular Biology
165:MRC Laboratory of Molecular Biology
73:MRC Laboratory of Molecular Biology
14:
2112:
2101:
2100:
1707:
1032:"Sjors Scheres | Royal Society"
1902:Bilbao Crystallographic Server
926:Goedert M, Scheres SH (2022).
1:
221:Maximum likelihood estimation
217:Cryogenic electron microscopy
175:Scheres studied Chemistry at
2181:Fellows of the Royal Society
156:Sjors Hendrik Willem Scheres
1950:Crystal Growth & Design
1242:Timeline of crystallography
311:Fellow of the Royal Society
2197:
1761:Nuclear magnetic resonance
952:10.1038/s41586-022-04650-z
779:10.1038/s41586-021-03911-7
278:, as well as filaments of
219:(cryo-EM) images based on
195:, which was supervised by
2166:Utrecht University alumni
2096:
1965:Journal of Crystal Growth
1705:
894:10.1038/s41586-020-2317-6
607:10.1038/s41586-020-2829-0
549:10.1016/j.jsb.2012.09.006
500:10.1016/j.jmb.2011.11.010
121:
58:
25:
2176:Bijvoet Medal recipients
1831:Single particle analysis
1689:Hermann–Mauguin notation
250:in a collaboration with
1955:Crystallography Reviews
1799:Isomorphous replacement
1593:Lomer–Cottrell junction
1153:"365 days: Nature's 10"
837:10.1126/science.abm7285
292:Multiple system atrophy
209:Postdoctoral researcher
193:Protein Crystallography
1468:Spinodal decomposition
350:Gold medal KNCV (2015)
229:Empirical Bayes method
2151:Structural biologists
2008:Gregori Aminoff Prize
1804:Molecular replacement
336:Bijvoet medal of the
258:, who is also at the
1314:Structure prediction
356:who mattered in 2014
207:Scheres worked as a
1578:Cottrell atmosphere
1558:Partial dislocation
1302:Restriction theorem
1169:2014Natur.516..311.
1151:Callaway E (2014).
944:2022Natur.605..310S
886:2020Natur.585..464S
829:2022Sci...375..167Y
771:2021Natur.598..359S
721:10.1038/nature23002
713:2017Natur.547..185F
664:10.1038/nature14892
656:2015Natur.525..212B
599:2020Natur.587..152N
531:Scheres SH (2012).
482:Scheres SH (2012).
422:Scheres SH (2003).
327:Leeuwenhoek Lecture
284:Alzheimer's disease
272:Alzheimer's disease
1998:Carl Hermann Medal
1809:Molecular dynamics
1656:Defects in diamond
1651:Stone–Wales defect
1297:Reciprocal lattice
1259:Biocrystallography
379:scholar.google.com
185:Utrecht University
177:Utrecht University
83:Utrecht University
50:Utrecht University
2128:
2127:
2092:
2091:
1699:Thermal ellipsoid
1664:
1663:
1573:Frank–Read source
1533:
1532:
1399:Aperiodic crystal
1365:
1364:
1247:Crystallographers
1012:mrc-lmb.cam.ac.uk
938:(7909): 310–314.
880:(7825): 464–469.
823:(6577): 167–172.
765:(7880): 359–363.
593:(7832): 152–156.
233:Protein structure
161:
153:
152:
60:Scientific career
2188:
2116:
2115:
2104:
2103:
2047:
1970:Kristallografija
1824:Gerchberg–Saxton
1719:Characterisation
1711:
1694:Structure factor
1498:
1483:Ostwald ripening
1320:
1265:
1221:
1214:
1207:
1198:
1191:
1190:
1180:
1163:(7531): 311–19.
1148:
1142:
1141:
1139:
1138:
1124:
1118:
1117:
1115:
1114:
1099:
1093:
1092:
1090:
1089:
1074:
1068:
1067:
1065:
1063:
1052:
1046:
1045:
1043:
1042:
1036:royalsociety.org
1028:
1022:
1021:
1019:
1018:
1004:
998:
997:
995:
994:
980:
974:
973:
963:
922:
916:
915:
905:
865:
859:
858:
848:
807:
801:
800:
790:
749:
743:
742:
732:
707:(7662): 185–90.
692:
686:
685:
675:
650:(7568): 212–17.
635:
629:
628:
618:
577:
571:
570:
560:
528:
522:
521:
511:
479:
473:
472:
453:10.1038/nmeth992
436:
430:
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389:
388:
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371:
159:
149:
146:
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142:
140:
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136:
134:
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111:Doctoral advisor
105:
30:
16:
2196:
2195:
2191:
2190:
2189:
2187:
2186:
2185:
2131:
2130:
2129:
2124:
2088:
2045:
2012:
1984:
1936:
1888:
1859:CrystalExplorer
1835:
1819:Phase retrieval
1782:
1713:
1712:
1703:
1660:
1639:Schottky defect
1538:Perfect crystal
1529:
1525:Abnormal growth
1487:
1473:Supersaturation
1436:Miscibility gap
1417:
1410:
1361:
1318:
1282:Bravais lattice
1263:
1230:
1228:Crystallography
1225:
1195:
1194:
1178:10.1038/516311a
1150:
1149:
1145:
1136:
1134:
1126:
1125:
1121:
1112:
1110:
1101:
1100:
1096:
1087:
1085:
1076:
1075:
1071:
1061:
1059:
1056:"Sjors Scheres"
1054:
1053:
1049:
1040:
1038:
1030:
1029:
1025:
1016:
1014:
1006:
1005:
1001:
992:
990:
982:
981:
977:
924:
923:
919:
867:
866:
862:
809:
808:
804:
751:
750:
746:
694:
693:
689:
637:
636:
632:
579:
578:
574:
537:J. Struct. Biol
530:
529:
525:
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416:
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397:
396:
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383:
381:
373:
372:
368:
363:
323:
288:Alpha-synuclein
264:Amyloid fibrils
248:Gamma secretase
205:
173:
167:Cambridge, UK.
129:
103:
87:
54:
43:Alma mater
21:
12:
11:
5:
2194:
2192:
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2028:
2022:
2020:
2014:
2013:
2011:
2010:
2005:
2000:
1994:
1992:
1986:
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1806:
1801:
1796:
1794:Direct methods
1790:
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1763:
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1715:
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1679:Ewald's sphere
1676:
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1661:
1659:
1658:
1653:
1648:
1647:
1646:
1641:
1631:
1630:
1629:
1624:
1622:Frenkel defect
1619:
1617:Bjerrum defect
1609:
1608:
1607:
1597:
1596:
1595:
1590:
1585:
1583:Peierls stress
1580:
1575:
1570:
1565:
1560:
1555:
1553:Burgers vector
1545:
1543:Stacking fault
1540:
1534:
1531:
1530:
1528:
1527:
1522:
1517:
1512:
1506:
1504:
1502:Grain boundary
1495:
1489:
1488:
1486:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1450:
1449:
1448:
1446:Liquid crystal
1443:
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1317:
1316:
1311:
1309:Periodic table
1306:
1305:
1304:
1299:
1294:
1289:
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1273:
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1262:
1261:
1256:
1251:
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1238:
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1232:
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1226:
1224:
1223:
1216:
1209:
1201:
1193:
1192:
1143:
1119:
1094:
1069:
1047:
1023:
999:
975:
917:
860:
802:
744:
687:
630:
572:
523:
474:
441:Nature Methods
431:
414:
390:
365:
364:
362:
359:
358:
357:
351:
348:
341:
334:
322:
319:
256:Michel Goedert
204:
201:
172:
169:
151:
150:
145:/sjors-scheres
141:/group-leaders
127:
123:
122:
119:
118:
113:
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23:
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13:
10:
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6:
4:
3:
2:
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2179:
2177:
2174:
2172:
2169:
2167:
2164:
2162:
2159:
2157:
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2152:
2149:
2147:
2146:Living people
2144:
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2120:
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2109:
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2019:
2015:
2009:
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2001:
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1991:
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1844:
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1820:
1817:
1815:
1814:Patterson map
1812:
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1805:
1802:
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1724:
1722:
1720:
1716:
1710:
1700:
1697:
1695:
1692:
1690:
1687:
1685:
1684:Friedel's law
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2050:Associations
2018:Organisation
1510:Disclination
1441:Polymorphism
1404:Quasicrystal
1347:Orthorhombic
1287:Miller index
1235:Key concepts
1160:
1156:
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1135:. Retrieved
1131:
1122:
1111:. Retrieved
1109:. 2017-06-16
1106:
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1086:. Retrieved
1084:. 2018-04-27
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447:(1): 27–29.
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402:
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382:. Retrieved
378:
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300:
280:Amyloid beta
241:
206:
174:
155:
154:
97:
66:Institutions
59:
2141:1975 births
2003:Ewald Prize
1771:Diffraction
1749:Diffraction
1732:Diffraction
1674:Bragg plane
1669:Bragg's law
1548:Dislocation
1463:Segregation
1375:Crystallite
1292:Point group
1062:10 December
354:Nature's 10
345:EMBO Member
276:Tauopathies
268:Tau protein
35:Nationality
2135:Categories
1787:Algorithms
1776:Scattering
1754:Scattering
1737:Scattering
1605:Slip bands
1568:Cross slip
1418:transition
1352:Tetragonal
1342:Monoclinic
1254:Metallurgy
1137:2018-07-31
1132:en.kncv.nl
1113:2018-07-31
1088:2018-07-31
1041:2021-05-16
1017:2022-04-15
993:2018-07-31
408:2018-07-31
384:2018-07-31
361:References
252:Shi Yigong
1894:Databases
1357:Triclinic
1337:Hexagonal
1277:Unit cell
1269:Structure
428:(Thesis).
197:Piet Gros
171:Education
116:Piet Gros
2107:Category
1942:Journals
1874:OctaDist
1869:JANA2020
1841:Software
1727:Electron
1644:F-center
1431:Eutectic
1392:Fiveling
1387:Twinning
1380:Equiaxed
1187:25519114
970:35344985
912:32461689
855:35025654
797:34588692
739:28678775
682:26280335
625:33087931
567:23000701
518:22100448
469:20967953
461:17179934
343:Elected
296:TMEM106B
237:Ferritin
187:for his
133:.mrc-lmb
2119:Commons
2067:Germany
1744:Neutron
1634:Vacancy
1493:Defects
1478:GP-zone
1324:Systems
1165:Bibcode
961:9095482
940:Bibcode
903:7116528
882:Bibcode
846:7612234
825:Bibcode
817:Science
788:7611841
767:Bibcode
730:5552202
709:Bibcode
673:4568306
652:Bibcode
616:7611073
595:Bibcode
558:3690530
509:3314964
329:of the
211:at the
143:/n-to-s
126:Website
2062:France
2057:Europe
1990:Awards
1520:Growth
1370:Growth
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1157:Nature
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932:Nature
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874:Nature
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347:(2017)
340:(2018)
333:(2022)
321:Awards
203:Career
104:(2003)
102:
93:Thesis
2084:Japan
2031:IOBCr
1884:SHELX
1879:Olex2
1766:X-ray
1416:Phase
1332:Cubic
988:eLife
465:S2CID
303:eLife
290:from
282:from
189:DPhil
38:Dutch
2026:IUCr
1927:ICDD
1922:ICSD
1907:CCDC
1854:Coot
1849:CCP4
1600:Slip
1563:Kink
1183:PMID
1064:2023
966:PMID
908:PMID
851:PMID
793:PMID
735:PMID
678:PMID
621:PMID
563:PMID
514:PMID
457:PMID
294:and
244:UTSW
231:for
135:.cam
131:www2
2041:DMG
2036:RAS
1932:PDB
1917:COD
1912:CIF
1864:DSR
1588:GND
1515:CSL
1173:doi
1161:516
956:PMC
948:doi
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898:PMC
890:doi
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833:doi
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611:PMC
603:doi
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266:of
191:in
160:FRS
139:.uk
137:.ac
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