318:
295:
192:
217:
324:
223:
2096:
63:
1186:
resolvase. As such, the complex cleaves the links between two homologous chromosomes that form during homologous recombination. This allows the two linked chromosomes to resolve into two unconnected double-strand DNA molecules. The
331:
230:
853:
834:
153:
2029:
2003:
2120:
1279:
1261:
1664:
317:
1719:
1972:
1903:
294:
1174:
The version of SLX4 present in humans and other mammals acts as a sort of scaffold upon which other proteins form several different
1085:
1092:
1987:
1248:
1227:
2130:
216:
191:
1244:
60:
1223:
1962:
1869:
133:
1191:
interacts with SLX4 in the DNA repair process, specifically in interstrand crosslink repair. SLX4 also associates with
330:
229:
1891:
1715:
1708:
1203:
of homologous recombination. The DNA repair function of SLX4 is involved in sensitivity to proton beam radiation.
323:
222:
1886:
1808:
1657:
1200:
1164:
898:
141:
879:
1998:
1908:
1703:
1175:
1764:
205:
1595:"Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation"
1689:
120:
2125:
2099:
1786:
1650:
1068:
1064:
1060:
1056:
1046:
1042:
1038:
1034:
1328:
165:
1446:
Svendsen JM, Smogorzewska A, Sowa ME, O'Connell BC, Gygi SP, Elledge SJ, Harper JW (July 2009).
1030:
1015:
989:
968:
1982:
1624:
1575:
1526:
1477:
1448:"Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair"
1428:
1377:
1320:
1183:
113:
53:
1614:
1606:
1565:
1557:
1516:
1508:
1467:
1459:
1418:
1408:
1367:
1359:
1310:
410:
341:
285:
240:
1196:
1698:
1179:
385:
161:
1619:
1594:
1570:
1545:
1521:
1496:
1472:
1447:
1423:
1396:
1372:
1347:
1168:
768:
763:
758:
753:
748:
743:
738:
733:
728:
723:
718:
713:
708:
703:
698:
693:
677:
672:
667:
662:
657:
652:
647:
642:
626:
621:
616:
611:
606:
601:
2114:
2010:
1831:
1346:
Kim Y, Lach FP, Desetty R, Hanenberg H, Auerbach AD, Smogorzewska A (February 2011).
588:
1332:
1977:
1946:
1896:
1879:
1826:
1779:
1192:
403:
182:
145:
1610:
1593:
Liu Q, Underwood TS, Kung J, Wang M, Lu HM, Paganetti H, et al. (May 2016).
1561:
714:
DNA double-strand break processing involved in repair via single-strand annealing
169:
1284:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1266:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1463:
1315:
1298:
486:
1913:
1734:
1681:
1673:
1160:
302:
199:
149:
1497:"SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair"
1413:
798:
546:
424:
369:
356:
268:
255:
157:
1628:
1579:
1530:
1481:
1432:
1381:
1324:
1495:
Zhang H, Chen Z, Ye Y, Ye Z, Cao D, Xiong Y, et al. (November 2019).
1132:
1127:
1994:
1512:
1116:
943:
924:
1941:
1693:
1156:
910:
865:
90:
86:
82:
2066:
1821:
1774:
1769:
1188:
1100:
820:
124:, BTBD12, FANCP, MUS312, SLX4 structure-specific endonuclease subunit
769:
negative regulation of telomere maintenance via telomere lengthening
17:
1363:
2081:
2076:
2071:
2061:
2054:
2049:
2044:
2039:
2034:
2024:
2019:
1874:
1838:
1759:
1754:
1749:
1739:
783:
779:
1967:
1923:
1918:
1853:
1848:
1843:
1816:
1796:
1791:
1744:
137:
1646:
1729:
1724:
1397:"The mouse genetics toolkit: revealing function and mechanism"
1642:
1599:
International
Journal of Radiation Oncology, Biology, Physics
1395:
van der Weyden L, White JK, Adams DJ, Logan DW (June 2011).
1167:. Mutations in the gene are associated with the disease
393:
749:
double-strand break repair via homologous recombination
1163:, where it has important roles in the final steps of
558:
1955:
1934:
1862:
1807:
1680:
1546:"DNA end resection: many nucleases make light work"
1029:
1008:
982:
961:
724:
response to intra-S DNA damage checkpoint signaling
1240:
1238:
1236:
1219:
1217:
1215:
744:resolution of meiotic recombination intermediates
617:crossover junction endodeoxyribonuclease activity
340:
239:
1348:"Mutations of the SLX4 gene in Fanconi anemia"
1245:GRCm38: Ensembl release 89: ENSMUSG00000039738
1658:
8:
1544:Mimitou EP, Symington LS (September 2009).
1224:GRCh38: Ensembl release 89: ENSG00000188827
1665:
1651:
1643:
1026:
794:
754:meiotic DNA double-strand break processing
584:
381:
280:
177:
71:
1618:
1569:
1520:
1471:
1422:
1412:
1371:
1314:
729:positive regulation of catalytic activity
704:positive regulation of t-circle formation
709:cellular response to DNA damage stimulus
1211:
31:
345:
306:
301:
244:
203:
198:
7:
1297:Klein HL, Symington LS (July 2009).
1299:"Breaking up just got easier to do"
658:Holliday junction resolvase complex
1973:Proliferating Cell Nuclear Antigen
1904:Microhomology-mediated end joining
1005:
979:
958:
934:
915:
889:
870:
844:
825:
563:
481:
419:
398:
25:
2095:
2094:
1988:Meiotic recombination checkpoint
329:
322:
316:
293:
228:
221:
215:
190:
1201:single-strand annealing pathway
612:endodeoxyribonuclease activity
547:More reference expression data
435:right hemisphere of cerebellum
27:Protein involved in DNA repair
1:
739:interstrand cross-link repair
627:3'-flap endonuclease activity
622:5'-flap endonuclease activity
314:
213:
2121:Genes on human chromosome 16
1870:Transcription-coupled repair
1611:10.1016/j.ijrobp.2016.01.046
1562:10.1016/j.dnarep.2009.04.017
759:telomeric D-loop disassembly
463:stromal cell of endometrium
2147:
1892:Non-homologous end joining
1716:Nucleotide excision repair
1709:Poly ADP ribose polymerase
1464:10.1016/j.cell.2009.06.030
1316:10.1016/j.cell.2009.06.039
694:nucleotide-excision repair
2090:
1280:"Mouse PubMed Reference:"
1262:"Human PubMed Reference:"
1131:
1126:
1122:
1115:
1099:
1080:
1053:
1012:
1001:
986:
965:
954:
941:
937:
922:
918:
909:
896:
892:
877:
873:
864:
851:
847:
832:
828:
819:
804:
797:
793:
777:
607:enzyme activator activity
587:
583:
571:
566:
557:
544:
493:
484:
431:
422:
392:
384:
380:
363:
350:
313:
292:
283:
279:
262:
249:
212:
189:
180:
176:
131:
128:
118:
111:
106:
79:
74:
57:
52:
47:
43:
39:
34:
1887:Homology directed repair
1809:Homologous recombination
1414:10.1186/gb-2011-12-6-224
1189:SLX4 interacting protein
1182:-SLX4 complex acts as a
1165:homologous recombination
471:tibialis anterior muscle
1909:Postreplication repair
1704:Uracil-DNA glycosylase
1501:Nucleic Acids Research
1176:multiprotein complexes
1086:Chr 16: 3.58 – 3.61 Mb
521:neural layer of retina
439:pancreatic ductal cell
2131:Genes mutated in mice
347:16 A1|16 2.34 cM
308:Chromosome 16 (mouse)
206:Chromosome 16 (human)
2015:core protein complex
1690:Base excision repair
75:List of PDB id codes
48:Available structures
1787:DNA mismatch repair
1507:(19): 10181–10201.
1093:Chr 16: 3.98 – 4 Mb
643:ERCC4-ERCC1 complex
529:seminiferous tubule
1513:10.1093/nar/gkz769
899:ENSMUSG00000039738
764:t-circle formation
687:Biological process
636:Cellular component
595:Molecular function
2108:
2107:
1983:Adaptive response
1184:Holliday junction
1142:
1141:
1138:
1137:
1111:
1110:
1076:
1075:
1023:
1022:
997:
996:
976:
975:
950:
949:
931:
930:
905:
904:
886:
885:
860:
859:
841:
840:
789:
788:
699:DNA recombination
678:Slx1-Slx4 complex
579:
578:
575:
574:
553:
552:
540:
539:
478:
477:
376:
375:
275:
274:
102:
101:
98:
97:
58:Ortholog search:
16:(Redirected from
2138:
2098:
2097:
1667:
1660:
1653:
1644:
1633:
1632:
1622:
1590:
1584:
1583:
1573:
1541:
1535:
1534:
1524:
1492:
1486:
1485:
1475:
1443:
1437:
1436:
1426:
1416:
1392:
1386:
1385:
1375:
1343:
1337:
1336:
1318:
1294:
1288:
1287:
1276:
1270:
1269:
1258:
1252:
1242:
1231:
1221:
1199:and SAW1 in the
1124:
1123:
1095:
1088:
1071:
1027:
1018:
1006:
1002:RefSeq (protein)
992:
980:
971:
959:
935:
916:
890:
871:
845:
826:
795:
585:
564:
549:
533:ventricular zone
525:secondary oocyte
505:genital tubercle
489:
487:Top expressed in
482:
467:ventricular zone
427:
425:Top expressed in
420:
399:
382:
372:
359:
348:
333:
326:
320:
309:
297:
281:
271:
258:
247:
232:
225:
219:
208:
194:
178:
172:
170:SLX4 - orthologs
123:
116:
93:
72:
66:
45:
44:
32:
21:
2146:
2145:
2141:
2140:
2139:
2137:
2136:
2135:
2111:
2110:
2109:
2104:
2086:
1956:Other/ungrouped
1951:
1930:
1858:
1803:
1699:DNA glycosylase
1682:Excision repair
1676:
1671:
1641:
1636:
1592:
1591:
1587:
1543:
1542:
1538:
1494:
1493:
1489:
1445:
1444:
1440:
1394:
1393:
1389:
1352:Nature Genetics
1345:
1344:
1340:
1296:
1295:
1291:
1278:
1277:
1273:
1260:
1259:
1255:
1243:
1234:
1222:
1213:
1209:
1147:(also known as
1133:View/Edit Mouse
1128:View/Edit Human
1091:
1084:
1081:Location (UCSC)
1067:
1063:
1059:
1055:
1049:
1045:
1041:
1037:
1033:
1014:
988:
967:
880:ENSG00000188827
773:
719:DNA replication
682:
631:
602:protein binding
545:
536:
531:
527:
523:
519:
515:
511:
507:
503:
499:
485:
474:
469:
465:
461:
457:
453:
449:
445:
441:
437:
423:
367:
354:
346:
336:
335:
334:
327:
307:
284:Gene location (
266:
253:
245:
235:
234:
233:
226:
204:
181:Gene location (
132:
119:
112:
81:
59:
28:
23:
22:
15:
12:
11:
5:
2144:
2142:
2134:
2133:
2128:
2123:
2113:
2112:
2106:
2105:
2103:
2102:
2091:
2088:
2087:
2085:
2084:
2079:
2074:
2069:
2064:
2059:
2058:
2057:
2052:
2047:
2042:
2037:
2032:
2027:
2022:
2007:
2006:
2001:
1991:
1990:
1985:
1980:
1975:
1970:
1965:
1959:
1957:
1953:
1952:
1950:
1949:
1944:
1938:
1936:
1932:
1931:
1929:
1928:
1927:
1926:
1921:
1911:
1906:
1901:
1900:
1899:
1889:
1884:
1883:
1882:
1877:
1866:
1864:
1863:Other pathways
1860:
1859:
1857:
1856:
1851:
1846:
1841:
1836:
1835:
1834:
1824:
1819:
1813:
1811:
1805:
1804:
1802:
1801:
1800:
1799:
1794:
1784:
1783:
1782:
1777:
1772:
1767:
1762:
1757:
1752:
1747:
1742:
1737:
1732:
1727:
1713:
1712:
1711:
1706:
1701:
1686:
1684:
1678:
1677:
1672:
1670:
1669:
1662:
1655:
1647:
1640:
1639:External links
1637:
1635:
1634:
1585:
1556:(9): 983–995.
1536:
1487:
1438:
1401:Genome Biology
1387:
1364:10.1038/ng.750
1358:(2): 142–146.
1338:
1289:
1271:
1253:
1232:
1210:
1208:
1205:
1169:Fanconi anemia
1140:
1139:
1136:
1135:
1130:
1120:
1119:
1113:
1112:
1109:
1108:
1106:
1104:
1097:
1096:
1089:
1082:
1078:
1077:
1074:
1073:
1051:
1050:
1024:
1021:
1020:
1010:
1009:
1003:
999:
998:
995:
994:
984:
983:
977:
974:
973:
963:
962:
956:
952:
951:
948:
947:
939:
938:
932:
929:
928:
920:
919:
913:
907:
906:
903:
902:
894:
893:
887:
884:
883:
875:
874:
868:
862:
861:
858:
857:
849:
848:
842:
839:
838:
830:
829:
823:
817:
816:
811:
806:
802:
801:
791:
790:
787:
786:
775:
774:
772:
771:
766:
761:
756:
751:
746:
741:
736:
731:
726:
721:
716:
711:
706:
701:
696:
690:
688:
684:
683:
681:
680:
675:
670:
665:
660:
655:
650:
645:
639:
637:
633:
632:
630:
629:
624:
619:
614:
609:
604:
598:
596:
592:
591:
581:
580:
577:
576:
573:
572:
569:
568:
561:
555:
554:
551:
550:
542:
541:
538:
537:
535:
534:
530:
526:
522:
518:
514:
510:
509:tail of embryo
506:
502:
498:
494:
491:
490:
479:
476:
475:
473:
472:
468:
464:
460:
456:
452:
448:
444:
440:
436:
432:
429:
428:
416:
415:
407:
396:
390:
389:
386:RNA expression
378:
377:
374:
373:
365:
361:
360:
352:
349:
344:
338:
337:
328:
321:
315:
311:
310:
305:
299:
298:
290:
289:
277:
276:
273:
272:
264:
260:
259:
251:
248:
243:
237:
236:
227:
220:
214:
210:
209:
202:
196:
195:
187:
186:
174:
173:
130:
126:
125:
117:
109:
108:
104:
103:
100:
99:
96:
95:
77:
76:
68:
67:
56:
50:
49:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
2143:
2132:
2129:
2127:
2124:
2122:
2119:
2118:
2116:
2101:
2093:
2092:
2089:
2083:
2080:
2078:
2075:
2073:
2070:
2068:
2065:
2063:
2060:
2056:
2053:
2051:
2048:
2046:
2043:
2041:
2038:
2036:
2033:
2031:
2028:
2026:
2023:
2021:
2018:
2017:
2016:
2012:
2011:FANC proteins
2009:
2008:
2005:
2002:
2000:
1996:
1993:
1992:
1989:
1986:
1984:
1981:
1979:
1976:
1974:
1971:
1969:
1966:
1964:
1961:
1960:
1958:
1954:
1948:
1945:
1943:
1940:
1939:
1937:
1933:
1925:
1922:
1920:
1917:
1916:
1915:
1912:
1910:
1907:
1905:
1902:
1898:
1895:
1894:
1893:
1890:
1888:
1885:
1881:
1878:
1876:
1873:
1872:
1871:
1868:
1867:
1865:
1861:
1855:
1852:
1850:
1847:
1845:
1842:
1840:
1837:
1833:
1832:RecQ helicase
1830:
1829:
1828:
1825:
1823:
1820:
1818:
1815:
1814:
1812:
1810:
1806:
1798:
1795:
1793:
1790:
1789:
1788:
1785:
1781:
1778:
1776:
1773:
1771:
1768:
1766:
1763:
1761:
1758:
1756:
1753:
1751:
1748:
1746:
1743:
1741:
1738:
1736:
1733:
1731:
1728:
1726:
1723:
1722:
1721:
1717:
1714:
1710:
1707:
1705:
1702:
1700:
1697:
1696:
1695:
1691:
1688:
1687:
1685:
1683:
1679:
1675:
1668:
1663:
1661:
1656:
1654:
1649:
1648:
1645:
1638:
1630:
1626:
1621:
1616:
1612:
1608:
1604:
1600:
1596:
1589:
1586:
1581:
1577:
1572:
1567:
1563:
1559:
1555:
1551:
1547:
1540:
1537:
1532:
1528:
1523:
1518:
1514:
1510:
1506:
1502:
1498:
1491:
1488:
1483:
1479:
1474:
1469:
1465:
1461:
1457:
1453:
1449:
1442:
1439:
1434:
1430:
1425:
1420:
1415:
1410:
1406:
1402:
1398:
1391:
1388:
1383:
1379:
1374:
1369:
1365:
1361:
1357:
1353:
1349:
1342:
1339:
1334:
1330:
1326:
1322:
1317:
1312:
1308:
1304:
1300:
1293:
1290:
1285:
1281:
1275:
1272:
1267:
1263:
1257:
1254:
1250:
1246:
1241:
1239:
1237:
1233:
1229:
1225:
1220:
1218:
1216:
1212:
1206:
1204:
1202:
1198:
1194:
1190:
1185:
1181:
1177:
1172:
1170:
1166:
1162:
1158:
1154:
1150:
1146:
1134:
1129:
1125:
1121:
1118:
1114:
1107:
1105:
1102:
1098:
1094:
1090:
1087:
1083:
1079:
1072:
1070:
1066:
1062:
1058:
1052:
1048:
1044:
1040:
1036:
1032:
1028:
1025:
1019:
1017:
1011:
1007:
1004:
1000:
993:
991:
985:
981:
978:
972:
970:
964:
960:
957:
955:RefSeq (mRNA)
953:
946:
945:
940:
936:
933:
927:
926:
921:
917:
914:
912:
908:
901:
900:
895:
891:
888:
882:
881:
876:
872:
869:
867:
863:
856:
855:
850:
846:
843:
837:
836:
831:
827:
824:
822:
818:
815:
812:
810:
807:
803:
800:
796:
792:
785:
781:
776:
770:
767:
765:
762:
760:
757:
755:
752:
750:
747:
745:
742:
740:
737:
735:
732:
730:
727:
725:
722:
720:
717:
715:
712:
710:
707:
705:
702:
700:
697:
695:
692:
691:
689:
686:
685:
679:
676:
674:
671:
669:
666:
664:
661:
659:
656:
654:
653:cell junction
651:
649:
646:
644:
641:
640:
638:
635:
634:
628:
625:
623:
620:
618:
615:
613:
610:
608:
605:
603:
600:
599:
597:
594:
593:
590:
589:Gene ontology
586:
582:
570:
565:
562:
560:
556:
548:
543:
532:
528:
524:
520:
516:
512:
508:
504:
500:
496:
495:
492:
488:
483:
480:
470:
466:
462:
458:
454:
450:
446:
442:
438:
434:
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430:
426:
421:
418:
417:
414:
412:
408:
406:
405:
401:
400:
397:
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391:
387:
383:
379:
371:
366:
362:
358:
353:
343:
339:
332:
325:
319:
312:
304:
300:
296:
291:
287:
282:
278:
270:
265:
261:
257:
252:
242:
238:
231:
224:
218:
211:
207:
201:
197:
193:
188:
184:
179:
175:
171:
167:
163:
159:
155:
151:
147:
143:
139:
135:
127:
122:
115:
110:
105:
94:
92:
88:
84:
78:
73:
70:
69:
65:
62:
55:
51:
46:
42:
38:
33:
30:
19:
2014:
1995:DNA helicase
1978:8-Oxoguanine
1947:SOS response
1827:RecF pathway
1780:Excinuclease
1605:(1): 78–85.
1602:
1598:
1588:
1553:
1549:
1539:
1504:
1500:
1490:
1458:(1): 63–77.
1455:
1451:
1441:
1404:
1400:
1390:
1355:
1351:
1341:
1309:(1): 20–22.
1306:
1302:
1292:
1283:
1274:
1265:
1256:
1173:
1159:involved in
1152:
1148:
1144:
1143:
1069:NP_001389860
1065:NP_001389859
1061:NP_001389857
1057:NP_001389856
1054:
1047:NP_001389855
1043:NP_001389854
1039:NP_001389853
1035:NP_001389852
1013:
987:
966:
942:
923:
897:
878:
852:
833:
813:
808:
501:spermatocyte
455:right testis
409:
402:
129:External IDs
80:
29:
648:nucleoplasm
459:left testis
447:granulocyte
107:Identifiers
2126:DNA repair
2115:Categories
1935:Regulation
1914:Photolyase
1674:DNA repair
1550:DNA Repair
1407:(6): 224.
1251:, May 2017
1230:, May 2017
1207:References
1161:DNA repair
734:DNA repair
413:(ortholog)
368:4,003,770
355:3,979,105
267:3,611,606
254:3,581,181
150:HomoloGene
1755:XPG/ERCC5
1740:XPD/ERCC2
1031:NP_803423
1016:NP_115820
990:NM_177472
969:NM_032444
799:Orthologs
513:spermatid
158:GeneCards
2100:Category
1750:XPF/DDB1
1745:XPE/DDB1
1629:27084631
1580:19473888
1531:31495888
1482:19596235
1433:21722353
1382:21240275
1333:15429205
1325:19596231
1247:–
1226:–
1117:Wikidata
778:Sources:
668:telomere
517:gastrula
451:testicle
1942:SOS box
1694:AP site
1620:4889010
1571:2760233
1522:6821277
1473:2720686
1424:3218837
1373:3345287
1249:Ensembl
1228:Ensembl
1178:. The
1157:protein
1155:) is a
911:UniProt
866:Ensembl
805:Species
784:QuickGO
673:cytosol
663:nucleus
388:pattern
246:16p13.3
114:Aliases
2067:FANCD2
2062:FANCD1
1822:RecBCD
1775:RAD23B
1770:RAD23A
1627:
1617:
1578:
1568:
1529:
1519:
1480:
1470:
1431:
1421:
1380:
1370:
1331:
1323:
1149:BTBD12
1103:search
1101:PubMed
944:Q6P1D7
925:Q8IY92
821:Entrez
559:BioGPS
497:zygote
146:106299
138:613278
2082:FANCN
2077:FANCJ
2072:FANCI
2055:FANCM
2050:FANCL
2045:FANCG
2040:FANCF
2035:FANCE
2030:FANCC
2025:FANCB
2020:FANCA
1880:ERCC8
1875:ERCC6
1839:RAD51
1760:ERCC1
1329:S2CID
1197:RAD10
1153:FANCP
854:52864
835:84464
814:Mouse
809:Human
780:Amigo
443:gonad
411:Mouse
404:Human
351:Start
286:Mouse
250:Start
183:Human
154:23770
1968:PcrA
1924:CRY2
1919:CRY1
1854:LexA
1849:Slx4
1844:Sgs1
1817:RecA
1797:MSH2
1792:MLH1
1720:ERCC
1625:PMID
1576:PMID
1527:PMID
1478:PMID
1452:Cell
1429:PMID
1378:PMID
1321:PMID
1303:Cell
1193:RAD1
1180:SLX1
1151:and
1145:SLX4
394:Bgee
342:Band
303:Chr.
241:Band
200:Chr.
162:SLX4
134:OMIM
121:SLX4
91:4ZOU
87:4UYI
83:4M7C
64:RCSB
61:PDBe
35:SLX4
18:Slx4
2004:WRN
1999:BLM
1963:Ogt
1765:RPA
1735:XPC
1730:XPB
1725:XPA
1615:PMC
1607:doi
1566:PMC
1558:doi
1517:PMC
1509:doi
1468:PMC
1460:doi
1456:138
1419:PMC
1409:doi
1368:PMC
1360:doi
1311:doi
1307:138
567:n/a
364:End
263:End
166:OMA
142:MGI
54:PDB
2117::
2013::
1997::
1897:Ku
1623:.
1613:.
1603:95
1601:.
1597:.
1574:.
1564:.
1552:.
1548:.
1525:.
1515:.
1505:47
1503:.
1499:.
1476:.
1466:.
1454:.
1450:.
1427:.
1417:.
1405:12
1403:.
1399:.
1376:.
1366:.
1356:43
1354:.
1350:.
1327:.
1319:.
1305:.
1301:.
1282:.
1264:.
1235:^
1214:^
1195:,
1171:.
782:/
370:bp
357:bp
269:bp
256:bp
164:;
160::
156:;
152::
148:;
144::
140:;
136::
89:,
85:,
1718:/
1692:/
1666:e
1659:t
1652:v
1631:.
1609::
1582:.
1560::
1554:8
1533:.
1511::
1484:.
1462::
1435:.
1411::
1384:.
1362::
1335:.
1313::
1286:.
1268:.
288:)
185:)
168::
20:)
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