1018:
1030:
337:
534:
104:
53:
871:
163:(ES). The stage is generally determined by the presence or absence of metastases, whether or not the tumor appears limited to the thorax, and whether or not the entire tumor burden within the chest can feasibly be encompassed within a single radiotherapy portal. In general, if the tumor is confined to one lung and the lymph nodes close to that lung, the cancer is said to be LS. If cancer has spread beyond that, it is said to be ES.
458:
gastrointestinal tract, or bladder. It is estimated to account for 1,000 new cases a year in the U.S. Histologically similar to small-cell lung cancer, therapies for small-cell lung cancer are usually used to treat EPSCC. First-line treatment is usually with cisplatin and etoposide. In Japan, first-line treatment is shifting to irinotecan and cisplatin. When the primary site is in the skin, it is referred to as a
290:
2970:
2858:
2818:
3776:
3758:
1282:
146:
Extensive stage small cell lung cancer (SCLC) is classified as a rare disorder. Ten-year relative survival rate (combined limited and extensive SCLC) is 3.5% (4.3% for women, 2.8% for men). Survival can be higher or lower based on a combination of factors including stage, age, sex and race. While all
470:
This is an extremely rare type of small cell, and there has been little information in the scientific community. It appears to occur in only one or more lymph nodes, and nowhere else in the body. Treatment is similar to small cell lung cancer, but survival rates are much higher than other small-cell
301:
Small-cell carcinoma of the lung usually presents in the central airways and infiltrates the submucosa leading to narrowing of bronchial airways. Common symptoms include cough, dyspnea, weight loss, and debility. Over 70% of patients with small-cell carcinoma present with metastatic disease; common
665:
Chest radiation helps SCLC patients live longer by killing cancer cells and helping prevention of cancer recurrence. Another type of radiation, prophylactic cranial radiation, prevents central nervous system recurrence and can improve survival in patients with good performance status who have had a
611:
may be useful in the treatment of cisplatin-resistant cancer. About 68.1% of cisplatin-resistant cells appear to be sensitive to paclitaxel and 66.7% of paclitaxel-resistant cells to cisplatin. The mechanism for this activity is unknown. Paclitaxel-based chemotherapy showed modest activity in SCLC
272:
to treat patients with metastatic small cell lung cancer (SCLC) who failed to respond to platinum-based chemotherapy and at least one other line of treatment. Nivolumab is approved in more than 60 countries. According to LUNGevity
Foundation, “This approval marks a major milestone for the patients
882:
Long-term survival of more than 5 years can be achieved with proper treatment. According to the 17th World
Conference on Lung Cancer (WCLC), "patients who received chest radiation and prophylactic cranial irradiation along with a mean of five chemotherapy cycles could achieve a median survival of
202:
Because SCLC usually metastasizes widely very early on in the natural history of the tumor, and because nearly all cases respond dramatically to chemotherapy and/or radiotherapy, there has been little role for surgery in this disease since the 1970s. However, recent work suggests that in cases of
3794:
3740:
1264:
457:
Very rarely, the primary site for small-cell carcinoma is outside of the lungs and pleural space; in these cases, it is referred to as extrapulmonary small-cell carcinoma (EPSCC). Outside of the respiratory tract, small-cell carcinoma can appear in the cervix, prostate, liver, pancreas,
265:. Although this treatment is often effective, it can cause hair loss and fatigue. Prospective randomized trials with almost two years of follow-up have not shown neurocognitive ill-effects. Meta-analyses of randomized trials confirm that PCI provides significant survival benefits.
276:
In
September 2018, the results from the global, randomized phase I/III IMpower 133 trial were announced at the World Congress on Lung Cancer in Toronto, ON. In this study, patients with ES-SCLC were treated with standard carboplatin plus etoposide and were randomized to receive
914:
The SEER database tracks 5-year relative survival rates based on age, sex, and race and is considered the most accurate source of survival information. This database uses terms "Localized," "Regional," and "Distant" to describe various stages of small cell lung cancer.
250:, and the vast majority having at least some objective response. Responses in ES-SCLC are often of short duration, and the evidence surrounding the risk of treatment compared to the potential benefit of chemotherapy for people who have extensive SCLC is not clear.
563:
composed of primitive-appearing cells. As the name implies, the cells in small-cell carcinomas are smaller than normal cells, and barely have room for any cytoplasm. Some researchers identify this as a failure in the mechanism that controls the size of the cells.
1017:
867:, and in particular, regimens based on platinum-containing agents. However, most people with the disease relapse and median survival remains low. The overall incidence and mortality rates of SCLC in the United States have decreased during the past few decades.
890:"Despite recent advances adding immunotherapy to chemotherapy in the frontline setting, the median remains at about 1 year, the worst of any lung cancer subtype. There is a clear need for further trials and drug development to combat these poor outcomes.”
348:
Lung cancer is the leading cause of cancer-related deaths worldwide, accounting for the highest mortality rates among both men and women. When associated with the lung, SCLC is sometimes called "oat cell carcinoma" due to the flat cell shape and scanty
656:
are alive at 24 months compared to those who received chemotherapy alone, Canadian regulator had rejected funding
Tecentriq for extensive stage small-cell lung cancer "as too costly" followed by United Kingdom also citing "drug’s cost-effectiveness."
2128:
Pelosi G, Sonzogni A, Galetta D, Perrone F, Braidotti P, Manzotti M, et al. (April 2011). "Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type".
855:
5-year survival rates for small cell lung cancer (extensive and limited) range between 3.6% and 32.2% for women, and between 2.2% and 24.5% for men. Relative 5-year survival rate for both sexes has increased from 3.6% in 1975 to 6.7% in 2014.
548:
Regional: the cancer has spread to lymph nodes (or glands) within the chest (between limited and extensive stage SCLC). Lymph nodes act as a filtering system outside the lung, collecting cancer cells that are beginning to migrate out of the
751:
is the most promising new agent that substantially increased overall survival rate in relapsed small cell lung cancer among sensitive disease patients. As a single agent, lurbinectedin demonstrated following clinical results in refractory
2987:
2773:
436:
Although combined small-cell lung carcinoma is currently staged and treated similarly to "pure" small-cell carcinoma of the lung, recent research suggests surgery might improve outcomes in very early stages of this tumor type.
709:
Current guidelines recommend that patients who relapse > 6 months from initial therapy should be retreated with the original chemotherapy regimen. For patients who relapse in < 6 months, single-agent chemotherapy either
1029:
440:
Smoking is a significant risk factor. Symptoms and signs are as for other lung cancers. In addition, because of their neuroendocrine cell origin, small-cell carcinomas will often secrete substances that result in
3343:
3362:"ATLANTIS: a Phase III study of lurbinectedin/doxorubicin versus topotecan or cyclophosphamide/doxorubicin/vincristine in patients with small-cell lung cancer who have failed one prior platinum-containing line"
905:
small-cell lung carcinoma where 5-year relative survival rate (both sexes, all races, all ages) is 2.8%; however, women have higher 5-year survival rates, 3.4%, and men have lower 5-year survival rates, 2.2%.
987:, which mandated increased attention to certain recalcitrant cancers, including small cell lung cancer. That led to the National Cancer Institute supporting small cell–specific research through a consortium.
3253:
Paz-Ares LG, Trigo Perez JM, Besse B, Moreno V, Lopez R, Sala MA, et al. (2019). "Efficacy and safety profile of lurbinectedin in second-line SCLC patients: Results from a phase II single-agent trial".
522:
1095:
321:
2947:
517:
amplifications and amplification of MYC family members are found in 30% of SCLCs. Loss of heterozygocity on chromosome arm 3p is found in more than 80% of SCLCs, including the loss of
1441:
898:
disease, relative 5-year survival rate (both sexes, all races, all ages) is 21.3%; however, women have higher 5-year survival rates, 26.9%, and men have lower survival rates, 21.3%.
403:(and hence staged differently). There is usually early involvement of the hilar and mediastinal lymph nodes. The mechanisms of its metastatic progression are not well understood.
3741:"Small cell carcinoma of the Lung and Bronchus SEER Relative Survival Rates by Time Since Diagnosis, 2004-2017 By Stage at Diagnosis, Male, All Races (includes Hispanic), All Ages"
4077:
1419:
3117:
Mouri A, Yamaguchi O, Miyauchi S, Shiono A, Utsugi H, Nishihara F, et al. (January 2019). "Combination therapy with carboplatin and paclitaxel for small cell lung cancer".
762:
Overall survival rate of 15.2 months for sensitive disease (chemotherapy-free interval of ≥ 90 days) with a disease control rate of 79.3% and overall response rate of 46.6%, and
199:" (CR), which is defined as the disappearance of all radiological and clinical signs of tumor. However, relapse rate remains high, and median survival is only 18 to 24 months.
956:
5-year relative survival statistics are more accurate and, in some cases, higher when specific race and age range are combined with sex and stage at diagnosis. For example,
4951:
3411:"Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial"
2795:
3067:
975:
15% of lung cancers in the US are of this type. Small cell lung cancer occurs almost exclusively in smokers – most commonly in heavy smokers and rarely in non-smokers.
5159:
2551:
4809:
765:
Overall survival rate of 5.1 months for resistant (chemotherapy-free interval of < 90 days) with a disease control rate of 46.8% and overall response rate 21.3%.
353:. Caution is required when diagnosing SCLC because small cell mesothelioma – an extremely rare subtype of lung cancer – can be mistaken for small cell lung cancer.
203:
small, asymptomatic, node-negative SCLC's ("very limited stage"), surgical excision may improve survival when used prior to chemotherapy ("adjuvant chemotherapy").
5333:
5328:
4173:
3570:"Table 15.13: Small Cell Cancer of the Lung and Bronchus (Invasive), 5-Year Relative and Period Survival by Race, Sex, Diagnosis Year, Age and Stage at Diagnosis"
4966:
2929:
745:
in relapsed small-cell lung cancer yielded an overall response rate of 41.7%, median progression-free survival 4.2 months, and overall survival was 8.5 months.
2469:
652:
Tecentriq treatment costs on average $ 13,200 per month, depending on the dosage schedule. Despite updated data showing 30% more people with extensive stage
3534:
3701:
3099:
2103:
3509:
1647:
1115:"Advanced small cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin followed by radical surgery"
4940:
3081:
172:
2988:"FDA approves Imdelltra (tarlatamab-dlle), the first and only T-cell engager therapy for the treatment of extensive-stage small cell lung cancer"
2774:"Jazz Pharmaceuticals Announces U.S. FDA Accelerated Approval of Zepzelca (lurbinectedin) for the Treatment of Metastatic Small Cell Lung Cancer"
775:
as second-line therapy in a randomized phase 3 trial. While overall survival in this trial is not yet known, response rates at second line were
3719:
446:
389:
325:
273:
touched by this unrelenting disease and may motivate them to pursue further treatment where there previously were no other approved options.”
4986:
2097:
2008:
1983:
1283:"Small cell carcinoma of the Lung and Bronchus SEER 5-Year Relative Survival Rates, 2011-2017 By Sex and Race/Ethnicity, Ages 50-64, Distant"
1461:
5426:
5152:
3460:
1974:
Mitchell, Richard
Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). "Ch. 13, box on morphology of small-cell lung carcinoma".
5193:
1100:
5340:
4931:
4802:
4648:
143:, small cell carcinoma is more aggressive, with a shorter doubling time, higher growth fraction, and earlier development of metastases.
4041:
3605:
3045:
211:
In ES-SCLC, platinum-based combination chemotherapy is the standard of care, with radiotherapy added only to palliate symptoms such as
5004:
4961:
4217:
4166:
3820:
426:
412:
2718:
246:. Response rates are high even in extensive disease, with between 15% and 30% of subjects having a complete response to combination
3913:
2893:
3569:
4981:
4698:
258:
3294:"Antitumor activity of lurbinectedin (PM01183) and doxorubicin in relapsed small-cell lung cancer: results from a phase I study"
2747:
5373:
5145:
4702:
4535:
2495:
2174:"A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma"
5203:
2671:"Paclitaxel as third-line chemotherapy for small cell lung cancer failing both etoposide- and camptothecin-based chemotherapy"
572:
Small-cell lung cancer is most commonly treated with a combination of two drugs, which is more effective than one drug alone.
336:
4795:
4323:
3344:"PharmaMar and Bionical Emas Launch Expanded Access Program for Lurbinectedin in Relapsed Small Cell Lung Cancer in the U.S."
1376:
674:
If small cell lung cancer comes back after treatment, the following combination of drugs may be used as a salvage therapy:
533:
4923:
4640:
4159:
2875:
400:
140:
734:, have activity in relapsed SCLC. Of note, temozolomide yielded a response rate of 38% for brain metastases due to SCLC.
4429:
2953:
2841:
2835:
2801:
2724:
825:
817:
5350:
5252:
4860:
4687:
4604:
4237:
3998:
984:
883:
more than 5 years." In some cases, long-term survival of 10+ years is achieved with chemotherapy and radiation alone.
313:
2517:
433:, including extremely complex malignant tissue admixtures. C-SCLC is the only currently recognized subtype of SCLC.
4936:
4744:
4726:
4636:
4587:
4016:
429:(c-SCLC). Small-cell lung carcinoma can occur in combination with a wide variety of other histological variants of
5395:
5059:
4946:
4721:
4644:
4481:
4307:
4270:
1928:
Champaneria MC, Modlin IM, Kidd M, Eick GN (2006). "Friedrich
Feyrter: a precise intellect in a diffuse system".
1415:
1065:
484:
281:
or placebo. Atezolizumab was associated with a significant improvement in overall survival (HR for death = 0.70)
3027:
5390:
4976:
4877:
4855:
4749:
4682:
4617:
4491:
4471:
4438:
4416:
4378:
4088:
3360:
Farago AF, Drapkin BJ, Lopez-Vilarino de Ramos JA, Galmarini CM, Núñez R, Kahatt C, Paz-Ares L (January 2019).
2461:
442:
224:
178:
2084:
4971:
4887:
4830:
4227:
3587:
1531:
Mountain CF (September 1978). "Clinical biology of small cell carcinoma: relationship to surgical therapy".
791:
418:
385:
2911:
5436:
5421:
5277:
5108:
4610:
4434:
4374:
1999:
Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005).
845:
753:
653:
191:
Exceptionally high objective initial response rates (RR) of between 60% and 90% are seen in LS-SCLC using
136:
147:
lung cancers are associated with tobacco smoking, SCLC is very strongly associated with tobacco smoking.
4956:
4843:
4772:
4496:
3702:"Focus on immunotherapy and patient perspective highlight the IASLC 2019 Small Cell Lung Cancer Meeting"
552:
Distant: the cancer has spread (or metastasized) to other parts of the body (aka: extensive stage SCLC).
459:
317:
3877:
Muscat JE, Wynder EL (January 1995). "Lung cancer pathology in smokers, ex-smokers and never smokers".
2213:
1858:
Titulaer MJ, Verschuuren JJ (2008). "Lambert-Eaton myasthenic syndrome: tumor versus nontumor forms".
52:
5431:
4600:
4459:
4396:
4232:
2621:"A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship"
1867:
1407:
990:
As a result, new experimental drugs for small cell lung cancer are currently being tested, including
967:
National Cancer
Institute's SEER maintains publicly accessible database for specific survival rates.
821:
521:. One hundred translocations have so far been reported in SCLCs (see the "Mitelman Database" and the
377:
874:
Pie chart showing incidence of small-cell lung cancer (shown in red at right), as compared to other
5272:
5247:
5208:
5074:
4736:
4388:
4222:
3409:
Weiss JM, Csoszi T, Maglakelidze M, Hoyer RJ, Beck JT, Domine Gomez M, et al. (October 2019).
2620:
1665:
Horn L, Mansfield AS, Szczęsna A, Havel L, Krzakowski M, Hochmair MJ, et al. (December 2018).
1349:
Argiris A, Murren JR (2001). "Staging and clinical prognostic factors for small-cell lung cancer".
824:(NDA). An approval decision on the NDA is expected by February 15, 2021. On February 12, 2021, the
357:
103:
3745:
Surveillance, Epidemiology, and End
Results (SEER) Relative Survival Rates by Time Since Diagnosis
2566:
2533:
2332:"Extrapulmonary small cell carcinoma localized in lymph nodes: is it a different clinical entity?"
1287:
Surveillance, Epidemiology, and End
Results (SEER) Relative Survival Rates by Time Since Diagnosis
1269:
Surveillance, Epidemiology, and End
Results (SEER) Relative Survival Rates by Time Since Diagnosis
1162:
Capizzello A, Peponi E, Simou N, Ntaskagiannis D, Tasiou I, Kamina S, Tsekeris P (February 2011).
5416:
5385:
5213:
5126:
4896:
4569:
4401:
4364:
4242:
3613:
3271:
3142:
2669:
Kim SH, Kim MJ, Kim YJ, Chang H, Kim JW, Lee JO, Lee KW, Kim JH, Bang SM, Lee JS (October 2017).
2154:
1953:
1891:
1837:
1696:
1246:
991:
666:
complete response or a very good partial response to chemoradiation in LD or chemotherapy in ED.
373:
306:
181:(usually cisplatin or carboplatin plus etoposide) is administered together with concurrent chest
76:
5380:
4260:
3068:"NICE Cites Cost in Deciding Against Atezolizumab for Frontline Advanced Small Cell Lung Cancer"
3009:
1052:
804:, reduces chemotheraphy-induced toxicity in patients being treated for small-cell lung cancer.
3292:
Calvo E, Moreno V, Flynn M, Holgado E, Olmedo ME, Lopez Criado MP, et al. (October 2017).
2948:"FDA grants accelerated approval to tarlatamab-dlle for extensive stage small cell lung cancer"
616:
is active in relapsed SCLC and was approved for medical use in the United States in June 2020.
5184:
5174:
5033:
4822:
4713:
4128:
3962:
3894:
3859:
3816:
3643:
3442:
3391:
3325:
3235:
3186:
3134:
2700:
2651:
2601:
2545:
2443:
2402:
2353:
2271:
2195:
2146:
2093:
2060:
2004:
1979:
1945:
1883:
1829:
1794:
1745:
1714:
Nakazawa K, Kurishima K, Tamura T, Kagohashi K, Ishikawa H, Satoh H, Hizawa N (October 2012).
1688:
1629:
1581:
1540:
1513:
1453:
1358:
1331:
1223:
1193:
1144:
1113:
Nasu K, Hirakawa T, Okamoto M, Nishida M, Kiyoshima C, Matsumoto H, et al. (March 2011).
995:
369:
196:
92:
2930:"Concurrent Tecentriq Adds First Survival Benefit Seen in Small Cell Lung Cancer in 20 Years"
2426:
The Canadian Journal of Neurological Sciences. Le Journal Canadien des Sciences Neurologiques
4872:
4674:
4592:
4406:
4318:
3952:
3944:
3886:
3849:
3633:
3625:
3432:
3422:
3381:
3373:
3315:
3305:
3263:
3225:
3217:
3204:
Farago AF, Yeap BY, Stanzione M, Hung YP, Heist RS, Marcoux JP, et al. (October 2019).
3176:
3126:
3053:
2690:
2682:
2643:
2635:
2593:
2433:
2392:
2384:
2343:
2261:
2251:
2185:
2138:
2050:
2045:
2040:
1937:
1875:
1821:
1784:
1776:
1735:
1727:
1678:
1619:
1611:
1571:
1503:
1495:
1321:
1313:
1183:
1175:
1134:
1126:
837:
678:
612:
patients refractory to both etoposide- and camptothecin-based chemotherapy. The newer agent
262:
235:
216:
155:
Small-cell lung carcinoma has long been divided into two clinicopathological stages, termed
68:
3931:
Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, et al. (February 2019).
870:
5315:
5292:
5264:
5234:
5225:
4692:
4355:
2306:
1070:
1049:, perhaps best known as an actor on Saved by the Bell, died one month after the diagnosis.
813:
809:
480:
5137:
4787:
4443:
2289:
340:
Histopathologic image of small-cell carcinoma of the lung. CT-guided core needle biopsy.
3980:
1871:
1624:
1603:
1499:
1317:
1035:
Histopathologic image of small-cell carcinoma of the lung. CT-guided core needle biopsy.
5323:
5282:
5054:
4904:
4369:
4298:
4082:
3957:
3932:
3638:
3485:
3437:
3410:
3386:
3361:
3320:
3293:
3230:
3205:
2695:
2670:
2397:
2372:
2266:
2239:
2055:
2028:
1789:
1764:
1740:
1715:
1508:
1483:
1326:
1301:
1188:
1163:
1139:
1114:
1046:
422:
220:
3267:
5410:
5368:
5360:
5064:
3890:
3576:. Surveillance, Epidemiology, and End Results (SEER), U.S. National Cancer Institute.
3275:
2974:
2862:
2822:
1700:
1667:"First-Line Atezolizumab plus Chemotherapy in Extensive-Stage Small-Cell Lung Cancer"
1003:
937:
Women affected by small-cell lung cancer have higher 5-year survival rates than men.
801:
748:
613:
3165:"Treatment Options for Relapsed Small-Cell Lung Cancer: What Progress Have We Made?"
3146:
2158:
1957:
1910:
1895:
1841:
781:
91.7% in sensitive disease with median progression-free survival of 5.8 months , and
17:
5100:
4838:
4627:
4579:
4523:
4424:
4139:
3614:"Comparison of aspects of smoking among the four histological types of lung cancer"
2584:
Leslie M (November 2011). "Mysteries of the cell. How does a cell know its size?".
1615:
864:
860:
841:
742:
731:
727:
634:
494:
Symptomatic metastasis of SCCP to the brain is rare, and carries a poor prognosis.
278:
254:
247:
192:
182:
80:
4151:
2597:
341:
4093:
3604:
Smokers defined as current or former smoker of more than 1 year of duration. See
3221:
3130:
1576:
1559:
417:
When SCLC is found with one or more differentiated forms of lung cancer, such as
5118:
4914:
4850:
4565:
4340:
4252:
4123:
2686:
2190:
2173:
1164:"Pure small cell carcinoma of the prostate: a case report and literature review"
875:
829:
805:
797:
772:
690:
684:
591:
510:
430:
328:(LEMS) is a well-known paraneoplastic condition linked to small-cell carcinoma.
294:
289:
243:
239:
84:
3510:"FDA Grants Priority Review of Trilaciclib for Treating Small Cell Lung Cancer"
2639:
2491:
2388:
1648:"FDA Approves Opdivo for Certain Patients with Advanced Small Cell Lung Cancer"
1604:"Chemotherapy versus best supportive care for extensive small cell lung cancer"
1215:
305:
Due to its high grade neuroendocrine nature, small-cell carcinomas can produce
5069:
4476:
4345:
4335:
4191:
3948:
3933:"Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition"
3664:
2438:
2421:
2348:
2331:
2142:
1075:
715:
702:
696:
640:
608:
488:
396:
60:
3854:
3837:
1825:
1602:
Pelayo Alvarez M, Westeel V, Cortés-Jofré M, Bonfill Cosp X (November 2013).
1023:
Anaplastic (microcellular, oat cell) carcinoma from the lung (histopathology)
388:
and Cushing's syndrome. Approximately half of all individuals diagnosed with
5105:
5015:
4528:
4464:
4204:
4200:
4134:
4099:
3720:"SCLC Prognosis Remains 'Unsatisfactory' Despite Numerous Treatment Options"
3535:"FDA Approves Drug to Reduce Bone Marrow Suppression Caused by Chemotherapy"
3427:
3310:
2294:
1879:
1780:
1560:"Surgery for limited stage small cell lung cancer: time to fish or cut bait"
1484:"Consolidative radiation therapy for extensive-stage small cell lung cancer"
711:
628:
595:
585:
581:
392:(LEMS) will eventually be found to have a small-cell carcinoma of the lung.
372:). Hence, they express a variety of neuroendocrine markers, and may lead to
361:
350:
269:
231:
117:
72:
3966:
3863:
3647:
3629:
3446:
3395:
3329:
3239:
3190:
3138:
2704:
2655:
2605:
2447:
2357:
2275:
2256:
2199:
2150:
2064:
1949:
1887:
1833:
1798:
1749:
1692:
1633:
1585:
1517:
1457:
1362:
1335:
1227:
1197:
1148:
918:
5-year relative survival rate for "both sexes" and "all races" affected by
4104:
3898:
3377:
3206:"Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer"
3082:"Study: Chest Radiation Helps Small Cell Lung Cancer Patients Live Longer"
2422:"Brain metastasis from prostate small cell carcinoma: not to be neglected"
2406:
1683:
1666:
960:
Black / Female | Ages < 50 (at diagnosis) | Distant (ES SCLC) | = 7.0%.
5297:
5287:
5242:
5170:
5038:
5028:
3683:
3181:
3164:
2092:. World Health Organization Classification of Tumours. Lyon: IARC Press.
1544:
1384:
999:
963:
White / Female | Ages < 50 (at diagnosis) | Distant (ES SCLC) | = 6.1%
738:
560:
365:
309:
230:
Combination chemotherapy consists of a wide variety of agents, including
132:
97:
2492:"Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer"
1731:
878:
types, with fractions of smokers versus non-smokers shown for each type.
545:
Localized: the cancer is confined to the lung (aka: limited stage SCLC).
5023:
4486:
4293:
4265:
3461:"FDA Grants Priority Review to Trilaciclib to Treat Patients with SCLC"
2796:"FDA grants accelerated approval to lurbinectedin for metastatic small"
2086:
Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart
1130:
624:
The FDA has approved three immunotherapies for small cell lung cancer:
212:
4069:
2912:"FDA approves atezolizumab for extensive-stage small cell lung cancer"
2748:"Zepzelca- lurbinectedin injection, powder, lyophilized, for solution"
1941:
1179:
784:
33.3% in resistant disease with median progression-free of 3.5 months.
483:(approx. 1% of PC). Due to the fact that there is little variation in
127:, although it can occasionally arise in other body sites, such as the
5092:
4867:
4818:
4763:
4556:
4350:
4183:
3612:
Kenfield SA, Wei EK, Stampfer MJ, Rosner BA, Colditz GA (June 2008).
2647:
2420:
Erasmus CE, Verhagen WI, Wauters CA, van Lindert EJ (November 2002).
2371:
Nutting C, Horwich A, Fisher C, Parsons C, Dearnaley DP (June 1997).
2083:
Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC, eds. (2004).
833:
297:
showing a probable S2–S3 small cell carcinoma in the right side lung.
128:
120:
556:
At the time of diagnosis, 60–70% of people already have metastases.
3486:"Trilaciclib | intravenous CDK4/6 inhibitor | G1 Therapeutics, Inc"
2509:
4284:
3706:
The International Association for the Study of Lung Cancer (IASLC)
1716:"Specific organ metastases and survival in small cell lung cancer"
335:
288:
2973:
This article incorporates text from this source, which is in the
2861:
This article incorporates text from this source, which is in the
2821:
This article incorporates text from this source, which is in the
836:) as a treatment to reduce the frequency of chemotherapy-induced
2510:"Atlas of Genetics and Cytogenetics in Oncology and Haematology"
2240:"A rare bladder cancer--small cell carcinoma: review and update"
1812:
Babar SM (October 2013). "SIADH associated with ciprofloxacin".
1055:, Danish football player, died three months after the diagnosis.
518:
502:
466:
Extrapulmonary small-cell carcinoma localized in the lymph nodes
381:
124:
64:
5141:
4791:
4155:
3046:"Canadian regulator considers changes to new drug pricing plan"
1442:"Limited small-cell lung cancer: a potentially curable disease"
487:
levels, SCCP is normally diagnosed at an advanced stage, after
537:
Histopathology of small-cell carcinoma, with typical findings.
523:
Atlas of Genetics and Cytogenetics in Oncology and Haematology
514:
509:
and the retinoblastoma pathway are inactivated in most SCLCs.
506:
479:
Small-cell carcinoma of the prostate (SCCP) is a rare form of
261:(PCI) is often used in an attempt to prevent the emergence of
771:
Lurbinectedin is also being investigated in combination with
322:
syndrome of inappropriate antidiuretic hormone hypersecretion
3838:"Changing face of small-cell lung cancer: real and artifact"
2894:"FDA Approves Opdivo (Nivolumab) for Small Cell Lung Cancer"
425:, the malignant tumor is then diagnosed and classified as a
2172:
Gotoh M, Yamamoto Y, Huang CL, Yokomise H (November 2004).
395:
Small-cell carcinoma is most often more rapidly and widely
320:(ADH). Ectopic production of large amounts of ADH leads to
2876:"FDA Approves Opdivo for Small Cell Lung Cancer Treatment"
2532:
Caroline I.M. Underwood, M.D., Carolyn Glass, M.D., Ph.D.
1377:"Limited-stage small cell lung cancer: Initial management"
790:
Lurbinectedin is currently available in the U.S. under an
215:, pain from liver or bone metastases, or for treatment of
195:
alone, with between 45% and 75% of individuals showing a "
3815:. World Health Organization. 2014. pp. Chapter 5.1.
2330:
Cicin I, Usta U, Karagol H, Uzunoglu S, Kocak Z (2009).
188:
Chest RT has been shown to improve survival in LS-SCLC.
4017:"Dustin Diamond, 'Saved by the Bell' Star, Dead at 44"
1853:
1851:
1440:
Sherman CA, Rocha Lima CM, Turrisi AT (October 2000).
1420:
United States Department of Health and Human Services
886:
According to a European study published in BMJ Open,
4059:
3665:"Exceptional SCLC Survivors: 5-Year Median Survival"
2530:
Image by Mikael Häggström, MD. Source for findings:
223:, typically have a rapid, if temporary, response to
5359:
5314:
5263:
5233:
5224:
5192:
5183:
5117:
5091:
5047:
5013:
4995:
4922:
4913:
4895:
4886:
4829:
4762:
4735:
4712:
4673:
4662:
4626:
4578:
4555:
4544:
4509:
4452:
4415:
4387:
4306:
4292:
4283:
4251:
4199:
4190:
4114:
4063:
3684:"Lung cancer report: "They said it was bronchitis""
2776:(Press release). Jazz Pharmaceuticals. 15 June 2020
2029:"Investigating Tumor Heterogeneity in Mouse Models"
737:In a clinical trial of 50 patients, combination of
91:
40:
35:
3999:"Keytruda Shows Benefit in Small Cell Lung Cancer"
2003:. St. Louis, Mo: Elsevier Saunders. p. 759.
1765:"Mechanisms of small cell lung cancer metastasis"
1302:"Chemotherapy advances in small-cell lung cancer"
3735:
3733:
3564:
3562:
3560:
3558:
3556:
3554:
2619:Stordal B, Pavlakis N, Davey R (December 2007).
1402:
1400:
925:"Regional" small cell lung cancer 14.9%; and for
302:sites include liver, adrenals, bone, and brain.
3349:(Press release) – via www.prnewswire.com.
3287:
3285:
1597:
1595:
1265:"Small cell carcinoma of the Lung and Bronchus"
1222:, Treasure Island (FL): StatPearls Publishing,
5329:High-grade prostatic intraepithelial neoplasia
2462:"Lung: Translocations in Small Cell Carcinoma"
2001:Robbins and Cotran pathologic basis of disease
5153:
4803:
4167:
812:, makes the drug available in the U.S. under
8:
2550:: CS1 maint: multiple names: authors list (
1969:
1967:
922:"Localized" small cell lung cancer is 28.5%;
559:Small-cell carcinoma is an undifferentiated
3574:The SEER Cancer Statistics Review 1975-2015
2178:European Journal of Cardio-Thoracic Surgery
1608:The Cochrane Database of Systematic Reviews
859:Small-cell carcinoma is very responsive to
407:Combined small-cell lung carcinoma (c-SCLC)
5230:
5189:
5160:
5146:
5138:
4919:
4892:
4810:
4796:
4788:
4670:
4552:
4303:
4289:
4196:
4174:
4160:
4152:
4060:
3158:
3156:
2078:
2076:
2074:
2022:
2020:
1860:Annals of the New York Academy of Sciences
102:
51:
32:
3956:
3853:
3637:
3533:Office of the Commissioner (2021-02-12).
3436:
3426:
3385:
3319:
3309:
3229:
3180:
2694:
2437:
2396:
2347:
2265:
2255:
2189:
2054:
2044:
1788:
1763:Ko J, Winslow MM, Sage J (January 2021).
1739:
1682:
1623:
1575:
1507:
1452:(10): 1395–403, discussion 1403–4, 1409.
1325:
1214:Basumallik, Neil; Agarwal, Manuj (2023),
1187:
1138:
2377:Journal of the Royal Society of Medicine
1978:(8th ed.). Philadelphia: Saunders.
1251:National Organization for Rare Disorders
869:
840:for patients receiving certain types of
532:
3914:"A new focus on small cell lung cancer"
3795:"Small Cell Lung Cancer Survival Rates"
3777:"Cancer Survival Rates: White / Female"
3759:"Cancer Survival Rates: Black / Female"
3747:. U.S. National Cancer Institute. 2016.
3608:for percentages in numbers. Reference:
2046:10.1146/annurev-cancerbio-030419-033413
1289:. U.S. National Cancer Institute. 2016.
1271:. U.S. National Cancer Institute. 2016.
1088:
1013:
173:Limited-stage small cell lung carcinoma
3836:Ettinger DS, Aisner J (October 2006).
3100:"Treatment for Small Cell Lung Cancer"
2543:
2373:"Small-cell carcinoma of the prostate"
941:Localized: Women – 32.2% | Men – 24.5%
928:"Distant" small cell lung cancer 2.9%.
4987:Basaloid squamous cell lung carcinoma
2556:Last author update: 20 September 2022
944:Regional: Women – 17.0% | Men – 12.3%
123:that most commonly arises within the
7:
2472:from the original on 30 January 2015
2218:The Lecturio Medical Concept Library
1209:
1207:
983:In 2013, the US Congress passed the
475:Small-cell carcinoma of the prostate
257:occurs in a subject with SCLC, then
5341:List of people with prostate cancer
4649:Papillary serous cystadenocarcinoma
3163:Qin A, Kalemkerian GP (June 2018).
2990:(Press release). Amgen. 16 May 2024
2290:Extrapulmonary Small Cell Carcinoma
2214:"Lambert-Eaton Myasthenic Syndrome"
2109:from the original on 23 August 2009
1671:The New England Journal of Medicine
1500:10.3978/j.issn.2218-6751.2015.04.02
1318:10.3978/j.issn.2072-1439.2013.07.43
1300:Chan BA, Coward JI (October 2013).
453:Extrapulmonary small-cell carcinoma
4218:Combined small-cell lung carcinoma
3588:"Small Cell Lung Cancer Treatment"
3052:. 20 February 2020. Archived from
1488:Translational Lung Cancer Research
1408:"Small Cell Lung Cancer Treatment"
947:Distant: Women – 3.6% | Men – 2.2%
505:is mutated in 70 to 90% of SCLCs.
427:combined small cell lung carcinoma
413:Combined small-cell lung carcinoma
25:
3268:10.1200/JCO.2019.37.15_suppl.8506
3028:"Updated exploratory OS analysis"
2916:U.S. Food and Drug Administration
2836:"Drug Trials Snapshots: Zepzelca"
2244:Orphanet Journal of Rare Diseases
447:Lambert–Eaton myasthenic syndrome
390:Lambert–Eaton myasthenic syndrome
326:Lambert–Eaton myasthenic syndrome
268:In August 2018, the FDA approved
63:of a small-cell carcinoma of the
3663:Davenport L (20 December 2016).
3010:"What is the cost of Tecentriq?"
2968:
2856:
2816:
2520:from the original on 2011-02-23.
2498:from the original on 2016-05-29.
2027:Tammela T, Sage J (March 2020).
1028:
1016:
985:Recalcitrant Cancer Research Act
979:Recalcitrant Cancer Research Act
952:Survival rates by race, sex, age
901:The prognosis is far grimmer in
726:Several newer agents, including
368:called Feyrter cells (named for
356:It is thought to originate from
259:prophylactic cranial irradiation
4536:Syringocystadenoma papilliferum
4052:] (in Danish). 9 July 2023.
3682:Ketteler J (October 16, 2009).
2033:Annual Review of Cancer Biology
4324:Familial adenomatous polyposis
3912:Richards S (7 February 2019).
2719:"Zepzelca: FDA-Approved Drugs"
1616:10.1002/14651858.CD001990.pub3
1482:Singer L, Yom SS (June 2015).
1:
5345:
5005:Combined small-cell carcinoma
4967:Salivary gland–like carcinoma
4924:Non-small-cell lung carcinoma
4699:Paget's disease of the breast
4641:Pancreatic serous cystadenoma
2598:10.1126/science.334.6059.1047
2534:"Lung - Small cell carcinoma"
1814:The Annals of Pharmacotherapy
1558:Shepherd FA (February 2010).
401:non-small-cell lung carcinoma
5374:Extramammary Paget's disease
4703:Extramammary Paget's disease
4430:Multiple endocrine neoplasia
3891:10.1016/0304-3835(94)03608-l
3842:Journal of Clinical Oncology
3256:Journal of Clinical Oncology
3222:10.1158/2159-8290.CD-19-0582
3169:Journal of Oncology Practice
3131:10.1016/j.resinv.2018.09.004
2954:Food and Drug Administration
2842:Food and Drug Administration
2802:Food and Drug Administration
2725:Food and Drug Administration
1577:10.1097/JTO.0b013e3181c8cbf5
1564:Journal of Thoracic Oncology
1101:Dorland's Medical Dictionary
376:production of hormones like
5427:Infectious causes of cancer
5351:Transitional-cell carcinoma
5253:Germ cell neoplasia in situ
4941:Mucinous cystadenocarcinoma
4861:Nasopharyngeal angiofibroma
4688:Pancreatic ductal carcinoma
4605:Mucinous cystadenocarcinoma
4238:Transitional cell carcinoma
2687:10.1097/MD.0000000000008176
2238:Ismaili N (November 2011).
2191:10.1016/j.ejcts.2004.08.002
1306:Journal of Thoracic Disease
314:adrenocorticotropic hormone
5453:
5204:Sertoli–Leydig cell tumour
4745:Medullary breast carcinoma
4727:Invasive lobular carcinoma
4637:Ovarian serous cystadenoma
4588:Signet ring cell carcinoma
3262:(supl, abstr 8506): 8506.
3070:. Reuters. 6 January 2020.
2640:10.1016/j.ctrv.2007.07.013
2389:10.1177/014107689709000615
1078:, investigational new drug
410:
170:
5396:Hirsuties coronae glandis
5060:Solitary pulmonary nodule
4947:Large-cell lung carcinoma
4722:Lobular carcinoma in situ
4645:Serous cystadenocarcinoma
4482:Clear-cell adenocarcinoma
4271:Bartholin gland carcinoma
4182:Glandular and epithelial
3981:"ORY-1001 – Patient Info"
3949:10.1126/scisignal.aau2922
3592:National Cancer Institute
3119:Respiratory Investigation
2514:atlasgeneticsoncology.org
2466:atlasgeneticsoncology.org
2439:10.1017/S0317167100002250
2349:10.1080/02841860802495370
2143:10.1007/s00428-010-1011-8
1911:"Small Cell Mesothelioma"
1416:National Cancer Institute
1412:National Cancer Institute
485:prostate specific antigen
59:
50:
5391:Erythroplasia of Queyrat
4977:Papillary adenocarcinoma
4878:Laryngeal papillomatosis
4856:Nasopharyngeal carcinoma
4750:Medullary thyroid cancer
4683:Mammary ductal carcinoma
4618:Mucoepidermoid carcinoma
4472:Adenoid cystic carcinoma
4439:Adrenocortical carcinoma
4379:Hepatocellular carcinoma
3855:10.1200/jco.2006.07.3841
3813:World Cancer Report 2014
2998:– via PR Newswire.
2784:– via PR Newswire.
2628:Cancer Treatment Reviews
1826:10.1177/1060028013502457
1247:"Small Cell Lung Cancer"
1216:"Small Cell Lung Cancer"
1168:Case Reports in Oncology
714:second-line therapy, or
513:is mutated in 2 to 10%.
443:paraneoplastic syndromes
386:paraneoplastic syndromes
253:If complete response to
225:whole brain radiotherapy
179:combination chemotherapy
141:non-small cell carcinoma
44:Small-cell lung cancer,
27:Type of malignant cancer
4972:Adenosquamous carcinoma
4932:Squamous-cell carcinoma
4228:Squamous-cell carcinoma
3104:Canadian Cancer Society
2307:"Merkel-cell carcinima"
1976:Robbins Basic Pathology
1915:The Mesothelioma Center
1880:10.1196/annals.1405.030
1781:10.15252/emmm.202013122
1769:EMBO Molecular Medicine
846:small-cell lung cancer.
792:expanded access program
419:squamous cell carcinoma
219:, which, in small-cell
5278:Endodermal sinus tumor
5109:solitary fibrous tumor
4611:Pseudomyxoma peritonei
4435:Adrenocortical adenoma
4375:Hepatocellular adenoma
3630:10.1136/tc.2007.022582
3490:www.g1therapeutics.com
2257:10.1186/1750-1172-6-75
1312:(Suppl 5): S565–S578.
1096:"small-cell carcinoma"
1066:Brown-SĂ©quard syndrome
879:
754:small cell lung cancer
654:small cell lung cancer
538:
345:
332:Small-cell lung cancer
298:
137:gastrointestinal tract
4957:Sarcomatoid carcinoma
4844:Esthesioneuroblastoma
4773:Acinic cell carcinoma
4497:Papillary hidradenoma
4021:Entertainment Tonight
3606:image page in Commons
3428:10.1093/annonc/mdz278
3378:10.2217/fon-2018-0597
3311:10.1093/annonc/mdx357
3056:on February 22, 2020.
1684:10.1056/NEJMoa1809064
933:Survival rates by sex
910:5-year survival rates
873:
536:
460:Merkel-cell carcinoma
339:
318:anti-diuretic hormone
292:
177:In cases of LS-SCLC,
5346:Small-cell carcinoma
4997:Small-cell carcinoma
4982:Giant-cell carcinoma
4601:Mucinous cystadenoma
4460:Neuroendocrine tumor
4397:Renal cell carcinoma
4233:Basal-cell carcinoma
4213:Small-cell carcinoma
3514:www.uspharmacist.com
3182:10.1200/JOP.18.00278
2936:. 25 September 2018.
1652:Immuno-Oncology News
1533:Seminars in Oncology
844:for extensive-stage
822:New Drug Application
681:(Cytoxan, Procytox),
603:Cisplatin-resistance
358:neuroendocrine cells
116:is a type of highly
114:Small-cell carcinoma
71:, minimal amount of
36:Small-cell carcinoma
18:Small cell carcinoma
5273:Embryonal carcinoma
5248:Spermatocytic tumor
5209:Sertoli cell tumour
5075:Bronchial leiomyoma
4737:Medullary carcinoma
4223:Verrucous carcinoma
4005:. 6 September 2017.
2592:(6059): 1047–1048.
1872:2008NYASA1132..129T
1732:10.3892/ol.2012.792
648:Funding controversy
637:(Tecentriq) (2018)
384:that may result in
67:showing cells with
5386:Bowenoid papulosis
5214:Leydig cell tumour
5127:Mediastinal tumors
4952:Rhabdoid carcinoma
4570:Cystadenocarcinoma
4402:Endometrioid tumor
4365:Cholangiocarcinoma
4253:Complex epithelial
4243:Inverted papilloma
4115:External resources
3415:Annals of Oncology
3298:Annals of Oncology
2538:Pathology Outlines
1930:Neuroendocrinology
1131:10.4081/rt.2011.e6
880:
670:In case of relapse
539:
346:
299:
285:Signs and symptoms
77:stippled chromatin
46:Oat-cell carcinoma
5404:
5403:
5310:
5309:
5306:
5305:
5175:urogenital system
5135:
5134:
5087:
5086:
5083:
5082:
5034:Immature teratoma
4823:respiratory tract
4785:
4784:
4781:
4780:
4758:
4757:
4714:Lobular carcinoma
4658:
4657:
4505:
4504:
4279:
4278:
4149:
4148:
4105:11010461000119101
4042:"Asbjørn Sennels"
3943:(567): eaau2922.
3937:Science Signaling
3848:(28): 4526–4527.
3421:(10): 1613–1621.
3304:(10): 2559–2566.
3216:(10): 1372–1387.
3032:Tecentriq-HCP.com
2882:. 17 August 2018.
2099:978-92-832-2418-1
2010:978-0-7216-0187-8
1985:978-1-4160-2973-1
1942:10.1159/000096050
1820:(10): 1359–1363.
1677:(23): 2220–2229.
1654:. 21 August 2018.
1180:10.1159/000324717
1010:Additional images
661:Radiation therapy
370:Friedrich Feyrter
197:complete response
111:
110:
30:Medical condition
16:(Redirected from
5444:
5231:
5190:
5162:
5155:
5148:
5139:
4920:
4893:
4873:Laryngeal cancer
4812:
4805:
4798:
4789:
4705:
4675:Ductal carcinoma
4671:
4651:
4607:
4593:Krukenberg tumor
4553:
4407:Renal oncocytoma
4319:Linitis plastica
4308:Gastrointestinal
4304:
4290:
4197:
4176:
4169:
4162:
4153:
4061:
4054:
4053:
4038:
4032:
4031:
4029:
4028:
4013:
4007:
4006:
3995:
3989:
3988:
3977:
3971:
3970:
3960:
3928:
3922:
3921:
3909:
3903:
3902:
3874:
3868:
3867:
3857:
3833:
3827:
3826:
3809:
3803:
3802:
3791:
3785:
3784:
3773:
3767:
3766:
3755:
3749:
3748:
3737:
3728:
3727:
3726:. 12 April 2023.
3716:
3710:
3709:
3698:
3692:
3691:
3679:
3673:
3672:
3660:
3654:
3651:
3641:
3602:
3596:
3595:
3584:
3578:
3577:
3566:
3549:
3548:
3546:
3545:
3530:
3524:
3523:
3521:
3520:
3506:
3500:
3499:
3497:
3496:
3482:
3476:
3475:
3473:
3472:
3467:. 17 August 2020
3457:
3451:
3450:
3440:
3430:
3406:
3400:
3399:
3389:
3357:
3351:
3350:
3340:
3334:
3333:
3323:
3313:
3289:
3280:
3279:
3250:
3244:
3243:
3233:
3210:Cancer Discovery
3201:
3195:
3194:
3184:
3160:
3151:
3150:
3114:
3108:
3107:
3096:
3090:
3089:
3078:
3072:
3071:
3064:
3058:
3057:
3042:
3036:
3035:
3024:
3018:
3017:
3006:
3000:
2999:
2997:
2995:
2984:
2978:
2972:
2971:
2967:
2965:
2963:
2944:
2938:
2937:
2926:
2920:
2919:
2908:
2902:
2901:
2890:
2884:
2883:
2872:
2866:
2860:
2859:
2855:
2853:
2851:
2832:
2826:
2820:
2819:
2815:
2813:
2811:
2792:
2786:
2785:
2783:
2781:
2770:
2764:
2763:
2761:
2759:
2744:
2738:
2737:
2735:
2733:
2715:
2709:
2708:
2698:
2666:
2660:
2659:
2625:
2616:
2610:
2609:
2581:
2575:
2574:
2571:Cleveland Clinic
2563:
2557:
2555:
2549:
2541:
2528:
2522:
2521:
2506:
2500:
2499:
2488:
2482:
2481:
2479:
2477:
2458:
2452:
2451:
2441:
2417:
2411:
2410:
2400:
2368:
2362:
2361:
2351:
2327:
2321:
2320:
2318:
2317:
2303:
2297:
2286:
2280:
2279:
2269:
2259:
2235:
2229:
2228:
2226:
2224:
2210:
2204:
2203:
2193:
2184:(5): 1047–1049.
2169:
2163:
2162:
2125:
2119:
2118:
2116:
2114:
2108:
2091:
2080:
2069:
2068:
2058:
2048:
2024:
2015:
2014:
1996:
1990:
1989:
1971:
1962:
1961:
1936:(5–6): 394–404.
1925:
1919:
1918:
1906:
1900:
1899:
1855:
1846:
1845:
1809:
1803:
1802:
1792:
1760:
1754:
1753:
1743:
1720:Oncology Letters
1711:
1705:
1704:
1686:
1662:
1656:
1655:
1644:
1638:
1637:
1627:
1610:(11): CD001990.
1599:
1590:
1589:
1579:
1555:
1549:
1548:
1528:
1522:
1521:
1511:
1479:
1473:
1472:
1470:
1469:
1460:. Archived from
1437:
1431:
1430:
1428:
1427:
1404:
1395:
1394:
1392:
1391:
1381:www.uptodate.com
1373:
1367:
1366:
1346:
1340:
1339:
1329:
1297:
1291:
1290:
1279:
1273:
1272:
1261:
1255:
1254:
1243:
1237:
1236:
1235:
1234:
1211:
1202:
1201:
1191:
1159:
1153:
1152:
1142:
1110:
1104:
1093:
1032:
1020:
838:myelosuppression
802:CKD4/6 inhibitor
687:(Adriamycin) and
679:Cyclophosphamide
631:(Opdivo), (2018)
263:brain metastases
236:cyclophosphamide
217:brain metastases
107:
106:
69:nuclear moulding
55:
33:
21:
5452:
5451:
5447:
5446:
5445:
5443:
5442:
5441:
5407:
5406:
5405:
5400:
5381:Bowen's disease
5355:
5302:
5293:Choriocarcinoma
5259:
5220:
5196:gonadal stromal
5195:
5179:
5166:
5136:
5131:
5113:
5079:
5070:Peripheral lung
5043:
5009:
4991:
4909:
4882:
4825:
4816:
4786:
4777:
4754:
4731:
4708:
4697:
4693:Comedocarcinoma
4666:
4664:
4654:
4635:
4622:
4599:
4574:
4548:
4546:
4540:
4511:
4501:
4448:
4411:
4383:
4356:Somatostatinoma
4299:adenocarcinomas
4297:
4275:
4261:Warthin's tumor
4247:
4186:
4180:
4150:
4145:
4144:
4110:
4109:
4072:
4058:
4057:
4040:
4039:
4035:
4026:
4024:
4023:. February 2021
4015:
4014:
4010:
3997:
3996:
3992:
3985:Oryzon Genomics
3979:
3978:
3974:
3930:
3929:
3925:
3911:
3910:
3906:
3876:
3875:
3871:
3835:
3834:
3830:
3823:
3811:
3810:
3806:
3793:
3792:
3788:
3775:
3774:
3770:
3757:
3756:
3752:
3739:
3738:
3731:
3718:
3717:
3713:
3700:
3699:
3695:
3681:
3680:
3676:
3662:
3661:
3657:
3618:Tobacco Control
3611:
3603:
3599:
3586:
3585:
3581:
3568:
3567:
3552:
3543:
3541:
3532:
3531:
3527:
3518:
3516:
3508:
3507:
3503:
3494:
3492:
3484:
3483:
3479:
3470:
3468:
3459:
3458:
3454:
3408:
3407:
3403:
3366:Future Oncology
3359:
3358:
3354:
3342:
3341:
3337:
3291:
3290:
3283:
3252:
3251:
3247:
3203:
3202:
3198:
3162:
3161:
3154:
3116:
3115:
3111:
3098:
3097:
3093:
3080:
3079:
3075:
3066:
3065:
3061:
3044:
3043:
3039:
3026:
3025:
3021:
3008:
3007:
3003:
2993:
2991:
2986:
2985:
2981:
2969:
2961:
2959:
2946:
2945:
2941:
2928:
2927:
2923:
2910:
2909:
2905:
2892:
2891:
2887:
2874:
2873:
2869:
2857:
2849:
2847:
2834:
2833:
2829:
2817:
2809:
2807:
2794:
2793:
2789:
2779:
2777:
2772:
2771:
2767:
2757:
2755:
2746:
2745:
2741:
2731:
2729:
2717:
2716:
2712:
2668:
2667:
2663:
2623:
2618:
2617:
2613:
2583:
2582:
2578:
2565:
2564:
2560:
2542:
2531:
2529:
2525:
2508:
2507:
2503:
2490:
2489:
2485:
2475:
2473:
2460:
2459:
2455:
2419:
2418:
2414:
2370:
2369:
2365:
2336:Acta Oncologica
2329:
2328:
2324:
2315:
2313:
2305:
2304:
2300:
2287:
2283:
2237:
2236:
2232:
2222:
2220:
2212:
2211:
2207:
2171:
2170:
2166:
2131:Virchows Archiv
2127:
2126:
2122:
2112:
2110:
2106:
2100:
2089:
2082:
2081:
2072:
2026:
2025:
2018:
2011:
1998:
1997:
1993:
1986:
1973:
1972:
1965:
1927:
1926:
1922:
1908:
1907:
1903:
1857:
1856:
1849:
1811:
1810:
1806:
1762:
1761:
1757:
1713:
1712:
1708:
1664:
1663:
1659:
1646:
1645:
1641:
1601:
1600:
1593:
1557:
1556:
1552:
1530:
1529:
1525:
1481:
1480:
1476:
1467:
1465:
1439:
1438:
1434:
1425:
1423:
1406:
1405:
1398:
1389:
1387:
1375:
1374:
1370:
1348:
1347:
1343:
1299:
1298:
1294:
1281:
1280:
1276:
1263:
1262:
1258:
1245:
1244:
1240:
1232:
1230:
1213:
1212:
1205:
1161:
1160:
1156:
1112:
1111:
1107:
1094:
1090:
1085:
1071:Cervical cancer
1062:
1053:Asbjørn Sennels
1043:
1036:
1033:
1024:
1021:
1012:
981:
973:
954:
935:
912:
903:extensive-stage
853:
814:expanded access
810:G1 Therapeutics
724:
672:
663:
650:
622:
605:
578:
570:
531:
500:
481:prostate cancer
477:
468:
455:
415:
409:
334:
287:
209:
175:
169:
161:extensive stage
153:
101:
45:
31:
28:
23:
22:
15:
12:
11:
5:
5450:
5448:
5440:
5439:
5434:
5429:
5424:
5419:
5409:
5408:
5402:
5401:
5399:
5398:
5393:
5388:
5383:
5378:
5377:
5376:
5365:
5363:
5357:
5356:
5354:
5353:
5348:
5343:
5338:
5337:
5336:
5326:
5324:Adenocarcinoma
5320:
5318:
5312:
5311:
5308:
5307:
5304:
5303:
5301:
5300:
5295:
5290:
5285:
5283:Gonadoblastoma
5280:
5275:
5269:
5267:
5261:
5260:
5258:
5257:
5256:
5255:
5250:
5239:
5237:
5228:
5222:
5221:
5219:
5218:
5217:
5216:
5211:
5200:
5198:
5187:
5181:
5180:
5178:
5177:
5167:
5165:
5164:
5157:
5150:
5142:
5133:
5132:
5130:
5129:
5123:
5121:
5115:
5114:
5112:
5111:
5103:
5097:
5095:
5089:
5088:
5085:
5084:
5081:
5080:
5078:
5077:
5072:
5067:
5062:
5057:
5055:Pancoast tumor
5051:
5049:
5045:
5044:
5042:
5041:
5036:
5031:
5026:
5020:
5018:
5011:
5010:
5008:
5007:
5001:
4999:
4993:
4992:
4990:
4989:
4984:
4979:
4974:
4969:
4964:
4959:
4954:
4949:
4944:
4937:Adenocarcinoma
4934:
4928:
4926:
4917:
4911:
4910:
4908:
4907:
4905:Tracheal tumor
4901:
4899:
4890:
4884:
4883:
4881:
4880:
4875:
4870:
4864:
4863:
4858:
4853:
4847:
4846:
4841:
4835:
4833:
4827:
4826:
4821:involving the
4817:
4815:
4814:
4807:
4800:
4792:
4783:
4782:
4779:
4778:
4776:
4775:
4769:
4767:
4760:
4759:
4756:
4755:
4753:
4752:
4747:
4741:
4739:
4733:
4732:
4730:
4729:
4724:
4718:
4716:
4710:
4709:
4707:
4706:
4695:
4690:
4685:
4679:
4677:
4668:
4660:
4659:
4656:
4655:
4653:
4652:
4632:
4630:
4624:
4623:
4621:
4620:
4615:
4614:
4613:
4597:
4596:
4595:
4584:
4582:
4576:
4575:
4573:
4572:
4562:
4560:
4550:
4542:
4541:
4539:
4538:
4533:
4532:
4531:
4526:
4515:
4513:
4512:skin appendage
4507:
4506:
4503:
4502:
4500:
4499:
4494:
4489:
4484:
4479:
4474:
4469:
4468:
4467:
4456:
4454:
4453:Other/multiple
4450:
4449:
4447:
4446:
4441:
4432:
4427:
4421:
4419:
4413:
4412:
4410:
4409:
4404:
4399:
4393:
4391:
4385:
4384:
4382:
4381:
4372:
4370:Klatskin tumor
4367:
4361:
4360:
4359:
4358:
4353:
4348:
4343:
4338:
4327:
4326:
4321:
4312:
4310:
4301:
4287:
4281:
4280:
4277:
4276:
4274:
4273:
4268:
4263:
4257:
4255:
4249:
4248:
4246:
4245:
4240:
4235:
4230:
4225:
4220:
4215:
4209:
4207:
4194:
4188:
4187:
4181:
4179:
4178:
4171:
4164:
4156:
4147:
4146:
4143:
4142:
4131:
4119:
4118:
4116:
4112:
4111:
4108:
4107:
4096:
4085:
4073:
4068:
4067:
4065:
4064:Classification
4056:
4055:
4050:Extra Magazine
4033:
4008:
3990:
3972:
3923:
3904:
3879:Cancer Letters
3869:
3828:
3822:978-9283204299
3821:
3804:
3786:
3768:
3750:
3729:
3724:Cancer Network
3711:
3693:
3674:
3655:
3653:
3652:
3624:(3): 198–204.
3597:
3579:
3550:
3525:
3501:
3477:
3465:Cancer Network
3452:
3401:
3372:(3): 231–239.
3352:
3335:
3281:
3245:
3196:
3175:(6): 369–370.
3152:
3109:
3091:
3073:
3059:
3037:
3019:
3001:
2979:
2939:
2921:
2903:
2885:
2867:
2846:. 15 June 2020
2827:
2806:. 15 June 2020
2787:
2765:
2754:. 15 June 2020
2739:
2710:
2661:
2634:(8): 688–703.
2611:
2576:
2558:
2523:
2501:
2483:
2453:
2432:(4): 375–377.
2412:
2383:(6): 340–341.
2363:
2342:(3): 354–360.
2322:
2298:
2281:
2230:
2205:
2164:
2137:(4): 497–503.
2120:
2098:
2070:
2016:
2009:
1991:
1984:
1963:
1920:
1901:
1866:(1): 129–134.
1847:
1804:
1755:
1726:(4): 617–620.
1706:
1657:
1639:
1591:
1570:(2): 147–149.
1550:
1539:(3): 272–279.
1523:
1494:(3): 211–214.
1474:
1432:
1396:
1368:
1357:(5): 437–447.
1351:Cancer Journal
1341:
1292:
1274:
1256:
1238:
1203:
1154:
1105:
1087:
1086:
1084:
1081:
1080:
1079:
1073:
1068:
1061:
1058:
1057:
1056:
1050:
1047:Dustin Diamond
1042:
1039:
1038:
1037:
1034:
1027:
1025:
1022:
1015:
1011:
1008:
980:
977:
972:
969:
965:
964:
961:
953:
950:
949:
948:
945:
942:
934:
931:
930:
929:
926:
923:
911:
908:
852:
849:
820:considers its
808:’s developer,
788:
787:
786:
785:
782:
769:
768:
767:
766:
763:
723:
720:
707:
706:
700:
694:
688:
682:
671:
668:
662:
659:
649:
646:
645:
644:
638:
632:
621:
618:
604:
601:
600:
599:
589:
577:
574:
569:
566:
554:
553:
550:
546:
530:
527:
499:
496:
476:
473:
467:
464:
454:
451:
423:adenocarcinoma
411:Main article:
408:
405:
333:
330:
293:Frontal chest
286:
283:
221:lung carcinoma
208:
205:
171:Main article:
168:
165:
152:
149:
139:. Compared to
109:
108:
95:
89:
88:
57:
56:
48:
47:
42:
38:
37:
29:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
5449:
5438:
5437:Rare diseases
5435:
5433:
5430:
5428:
5425:
5423:
5422:Cytopathology
5420:
5418:
5415:
5414:
5412:
5397:
5394:
5392:
5389:
5387:
5384:
5382:
5379:
5375:
5372:
5371:
5370:
5367:
5366:
5364:
5362:
5358:
5352:
5349:
5347:
5344:
5342:
5339:
5335:
5332:
5331:
5330:
5327:
5325:
5322:
5321:
5319:
5317:
5313:
5299:
5296:
5294:
5291:
5289:
5286:
5284:
5281:
5279:
5276:
5274:
5271:
5270:
5268:
5266:
5262:
5254:
5251:
5249:
5246:
5245:
5244:
5241:
5240:
5238:
5236:
5232:
5229:
5227:
5223:
5215:
5212:
5210:
5207:
5206:
5205:
5202:
5201:
5199:
5197:
5191:
5188:
5186:
5182:
5176:
5172:
5169:
5168:
5163:
5158:
5156:
5151:
5149:
5144:
5143:
5140:
5128:
5125:
5124:
5122:
5120:
5116:
5110:
5107:
5104:
5102:
5099:
5098:
5096:
5094:
5090:
5076:
5073:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5052:
5050:
5046:
5040:
5037:
5035:
5032:
5030:
5027:
5025:
5022:
5021:
5019:
5017:
5012:
5006:
5003:
5002:
5000:
4998:
4994:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4953:
4950:
4948:
4945:
4942:
4938:
4935:
4933:
4930:
4929:
4927:
4925:
4921:
4918:
4916:
4912:
4906:
4903:
4902:
4900:
4898:
4894:
4891:
4889:
4885:
4879:
4876:
4874:
4871:
4869:
4866:
4865:
4862:
4859:
4857:
4854:
4852:
4849:
4848:
4845:
4842:
4840:
4837:
4836:
4834:
4832:
4828:
4824:
4820:
4813:
4808:
4806:
4801:
4799:
4794:
4793:
4790:
4774:
4771:
4770:
4768:
4765:
4761:
4751:
4748:
4746:
4743:
4742:
4740:
4738:
4734:
4728:
4725:
4723:
4720:
4719:
4717:
4715:
4711:
4704:
4700:
4696:
4694:
4691:
4689:
4686:
4684:
4681:
4680:
4678:
4676:
4672:
4669:
4667:and medullary
4661:
4650:
4646:
4642:
4638:
4634:
4633:
4631:
4629:
4625:
4619:
4616:
4612:
4609:
4608:
4606:
4602:
4598:
4594:
4591:
4590:
4589:
4586:
4585:
4583:
4581:
4577:
4571:
4567:
4564:
4563:
4561:
4558:
4554:
4551:
4543:
4537:
4534:
4530:
4527:
4525:
4522:
4521:
4520:
4517:
4516:
4514:
4508:
4498:
4495:
4493:
4490:
4488:
4485:
4483:
4480:
4478:
4475:
4473:
4470:
4466:
4463:
4462:
4461:
4458:
4457:
4455:
4451:
4445:
4442:
4440:
4436:
4433:
4431:
4428:
4426:
4423:
4422:
4420:
4418:
4414:
4408:
4405:
4403:
4400:
4398:
4395:
4394:
4392:
4390:
4386:
4380:
4376:
4373:
4371:
4368:
4366:
4363:
4362:
4357:
4354:
4352:
4349:
4347:
4344:
4342:
4339:
4337:
4334:
4333:
4332:
4329:
4328:
4325:
4322:
4320:
4317:
4314:
4313:
4311:
4309:
4305:
4302:
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3799:SEER Database
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3347:Bionical Emas
3345:
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3015:
3011:
3005:
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2989:
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2980:
2976:
2975:public domain
2958:. 16 May 2024
2957:
2955:
2949:
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2934:curetoday.com
2931:
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2863:public domain
2845:
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2823:public domain
2805:
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2788:
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2728:
2726:
2720:
2714:
2711:
2706:
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2697:
2692:
2688:
2684:
2681:(42): e8176.
2680:
2676:
2672:
2665:
2662:
2657:
2653:
2649:
2645:
2641:
2637:
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2612:
2607:
2603:
2599:
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2587:
2580:
2577:
2572:
2568:
2567:"Lung Cancer"
2562:
2559:
2553:
2547:
2539:
2535:
2527:
2524:
2519:
2515:
2511:
2505:
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2132:
2124:
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2105:
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2095:
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2087:
2079:
2077:
2075:
2071:
2066:
2062:
2057:
2052:
2047:
2042:
2039:(1): 99–119.
2038:
2034:
2030:
2023:
2021:
2017:
2012:
2006:
2002:
1995:
1992:
1987:
1981:
1977:
1970:
1968:
1964:
1959:
1955:
1951:
1947:
1943:
1939:
1935:
1931:
1924:
1921:
1916:
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1905:
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1897:
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1827:
1823:
1819:
1815:
1808:
1805:
1800:
1796:
1791:
1786:
1782:
1778:
1775:(1): e13122.
1774:
1770:
1766:
1759:
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1747:
1742:
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1725:
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1519:
1515:
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1505:
1501:
1497:
1493:
1489:
1485:
1478:
1475:
1464:on 2019-02-05
1463:
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1455:
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1447:
1443:
1436:
1433:
1421:
1417:
1413:
1409:
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1116:
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1103:
1102:
1097:
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1074:
1072:
1069:
1067:
1064:
1063:
1059:
1054:
1051:
1048:
1045:
1044:
1041:Notable cases
1040:
1031:
1026:
1019:
1014:
1009:
1007:
1005:
1004:pembrolizumab
1001:
997:
993:
988:
986:
978:
976:
970:
968:
962:
959:
958:
957:
951:
946:
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940:
939:
938:
932:
927:
924:
921:
920:
919:
916:
909:
907:
904:
899:
897:
896:limited-stage
892:
891:
887:
884:
877:
872:
868:
866:
862:
857:
850:
848:
847:
843:
839:
835:
831:
827:
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819:
815:
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807:
803:
799:
795:
793:
783:
780:
779:
778:
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776:
774:
764:
761:
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759:
758:
757:
755:
750:
749:Lurbinectedin
746:
744:
740:
735:
733:
729:
721:
719:
718:can be used.
717:
713:
704:
701:
698:
695:
692:
689:
686:
683:
680:
677:
676:
675:
669:
667:
660:
658:
655:
647:
642:
639:
636:
633:
630:
627:
626:
625:
620:Immunotherapy
619:
617:
615:
614:lurbinectedin
610:
602:
597:
593:
590:
587:
583:
580:
579:
575:
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567:
565:
562:
557:
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508:
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497:
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486:
482:
474:
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465:
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461:
452:
450:
448:
444:
438:
434:
432:
428:
424:
420:
414:
406:
404:
402:
398:
393:
391:
387:
383:
379:
375:
371:
367:
363:
359:
354:
352:
343:
342:H&E stain
338:
331:
329:
327:
323:
319:
315:
311:
308:
303:
296:
291:
284:
282:
280:
274:
271:
266:
264:
260:
256:
251:
249:
245:
241:
237:
233:
228:
226:
222:
218:
214:
206:
204:
200:
198:
194:
189:
186:
184:
180:
174:
166:
164:
162:
158:
157:limited stage
151:Types of SCLC
150:
148:
144:
142:
138:
134:
130:
126:
122:
119:
115:
105:
99:
96:
94:
90:
86:
82:
78:
74:
70:
66:
62:
58:
54:
49:
43:
39:
34:
19:
5173:of the male
5101:Mesothelioma
5065:Central lung
4996:
4839:Nasal cavity
4524:Hidrocystoma
4518:
4444:HĂĽrthle cell
4425:Prolactinoma
4330:
4315:
4212:
4133:
4122:
4098:
4087:
4076:
4049:
4045:
4036:
4025:. Retrieved
4020:
4011:
4002:
3993:
3984:
3975:
3940:
3936:
3926:
3917:
3907:
3882:
3878:
3872:
3845:
3841:
3831:
3812:
3807:
3798:
3789:
3780:
3771:
3762:
3753:
3744:
3723:
3714:
3705:
3696:
3687:
3677:
3668:
3658:
3621:
3617:
3600:
3591:
3582:
3573:
3542:. Retrieved
3538:
3528:
3517:. Retrieved
3513:
3504:
3493:. Retrieved
3489:
3480:
3469:. Retrieved
3464:
3455:
3418:
3414:
3404:
3369:
3365:
3355:
3346:
3338:
3301:
3297:
3259:
3255:
3248:
3213:
3209:
3199:
3172:
3168:
3125:(1): 34–39.
3122:
3118:
3112:
3103:
3094:
3085:
3076:
3062:
3054:the original
3049:
3040:
3031:
3022:
3013:
3004:
2992:. Retrieved
2982:
2960:. Retrieved
2951:
2942:
2933:
2924:
2915:
2906:
2897:
2888:
2879:
2870:
2848:. Retrieved
2839:
2830:
2808:. Retrieved
2799:
2790:
2778:. Retrieved
2768:
2758:24 September
2756:. Retrieved
2751:
2742:
2730:. Retrieved
2722:
2713:
2678:
2674:
2664:
2631:
2627:
2614:
2589:
2585:
2579:
2570:
2561:
2537:
2526:
2513:
2504:
2486:
2474:. Retrieved
2465:
2456:
2429:
2425:
2415:
2380:
2376:
2366:
2339:
2335:
2325:
2314:. Retrieved
2310:
2301:
2288:
2284:
2247:
2243:
2233:
2221:. Retrieved
2217:
2208:
2181:
2177:
2167:
2134:
2130:
2123:
2111:. Retrieved
2085:
2036:
2032:
2000:
1994:
1975:
1933:
1929:
1923:
1914:
1904:
1863:
1859:
1817:
1813:
1807:
1772:
1768:
1758:
1723:
1719:
1709:
1674:
1670:
1660:
1651:
1642:
1607:
1567:
1563:
1553:
1536:
1532:
1526:
1491:
1487:
1477:
1466:. Retrieved
1462:the original
1449:
1445:
1435:
1424:. Retrieved
1422:. 1980-01-01
1411:
1388:. Retrieved
1380:
1371:
1354:
1350:
1344:
1309:
1305:
1295:
1286:
1277:
1268:
1259:
1250:
1241:
1231:, retrieved
1219:
1174:(1): 88–95.
1171:
1167:
1157:
1125:(1): 18–20.
1122:
1118:
1108:
1099:
1091:
989:
982:
974:
971:Epidemiology
966:
955:
936:
917:
913:
902:
900:
895:
893:
889:
888:
885:
881:
865:radiotherapy
861:chemotherapy
858:
854:
842:chemotherapy
832:(brand name
796:
789:
770:
747:
743:temozolomide
736:
732:bendamustine
728:temozolomide
725:
722:Novel agents
708:
705:(Camptosar)
673:
664:
651:
635:Atezolizumab
623:
606:
576:Chemotherapy
571:
558:
555:
540:
501:
493:
478:
471:carcinomas.
469:
456:
439:
435:
416:
394:
355:
347:
312:, including
304:
300:
279:atezolizumab
275:
267:
255:chemotherapy
252:
248:chemotherapy
229:
210:
201:
193:chemotherapy
190:
187:
183:radiotherapy
176:
160:
156:
154:
145:
113:
112:
81:FNA specimen
5432:Lung cancer
5119:Mediastinum
5048:By location
4851:Nasopharynx
4566:Cystadenoma
4519:sweat gland
4510:Adnexal and
4341:Glucagonoma
4124:MedlinePlus
3106:. May 2020.
1119:Rare Tumors
992:Iadademstat
876:lung cancer
830:trilaciclib
806:Trilaciclib
798:Trilaciclib
773:doxorubicin
691:Vincristine
685:Doxorubicin
592:Carboplatin
431:lung cancer
316:(ACTH) and
244:carboplatin
240:vincristine
85:Field stain
41:Other names
5411:Categories
4549:and serous
4492:Cylindroma
4477:Oncocytoma
4389:Urogenital
4346:Gastrinoma
4336:Insulinoma
4192:Epithelium
4027:2021-02-06
3918:Fred Hutch
3885:(1): 1–5.
3544:2021-02-16
3519:2020-12-28
3495:2020-12-28
3471:2020-12-04
3086:cancer.org
2898:cancer.org
2880:Cure Today
2316:2021-08-01
2250:(75): 75.
1468:2021-08-01
1426:2019-06-02
1390:2019-06-02
1233:2023-10-02
1220:StatPearls
1083:References
1076:Ibcasertib
816:while the
716:paclitaxel
703:Irinotecan
697:Paclitaxel
641:Tarlatamab
609:paclitaxel
489:metastasis
397:metastatic
362:APUD cells
61:Micrograph
5417:Carcinoma
5369:Carcinoma
5226:Germ cell
5194:Sex cord–
5185:Testicles
5106:Malignant
5016:carcinoma
4962:Carcinoid
4547:mucinous,
4529:Syringoma
4465:Carcinoid
4417:Endocrine
4205:carcinoma
4201:Papilloma
4135:eMedicine
4100:SNOMED CT
3276:190884224
3014:Drugs.com
2648:2123/4068
2295:eMedicine
1909:Selby K.
1701:205103452
851:Prognosis
828:approved
712:topotecan
693:(Oncovin)
629:Nivolumab
607:The drug
596:etoposide
586:etoposide
582:Cisplatin
568:Treatment
529:Diagnosis
364:) in the
351:cytoplasm
324:(SIADH).
270:nivolumab
232:cisplatin
159:(LS) and
118:malignant
93:Specialty
73:cytoplasm
5316:Prostate
5298:Embryoma
5288:Teratoma
5243:Seminoma
5039:Melanoma
5029:Lymphoma
4888:Lower RT
4831:Upper RT
4665:lobular,
4580:Mucinous
4331:pancreas
4294:Adenomas
4140:med/1336
3967:30723171
3864:17008688
3669:Medscape
3648:18390646
3447:31504118
3396:30362375
3330:28961837
3240:31416802
3191:29894661
3147:54471245
3139:30528688
2752:DailyMed
2705:29049199
2675:Medicine
2656:17881133
2606:22116854
2546:cite web
2518:Archived
2496:Archived
2476:30 April
2470:Archived
2448:12463494
2358:18979286
2276:22078012
2223:1 August
2200:15519208
2159:19159554
2151:21210145
2113:27 March
2104:Archived
2065:34164589
1958:25627846
1950:17028417
1896:22482871
1888:18567862
1842:36759747
1834:24259701
1799:33296145
1750:23205072
1693:30280641
1634:24282143
1625:11364206
1586:20101141
1518:26207205
1458:11098505
1446:Oncology
1414:. U.S.:
1385:UpToDate
1363:11693903
1336:24163749
1228:29494065
1198:21475596
1149:21464879
1060:See also
1000:Keytruda
996:ORY-1001
739:olaparib
561:neoplasm
498:Genetics
445:such as
366:bronchus
310:hormones
133:prostate
98:Oncology
5024:Sarcoma
4897:Trachea
4663:Ductal,
4559:general
4545:Cystic,
4487:Apudoma
4266:Thymoma
4094:D018288
4083:M8041/3
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