779:
791:
367:
359:
104:
53:
725:
246:
gastrointestinal tract, or bladder. It is estimated to account for 1,000 new cases a year in the U.S. Histologically similar to small-cell lung cancer, therapies for small-cell lung cancer are usually used to treat EPSCC. First-line treatment is usually with cisplatin and etoposide. In Japan, first-line treatment is shifting to irinotecan and cisplatin. When the primary site is in the skin, it is referred to as a
280:
2536:
2424:
2384:
1001:
258:
This is an extremely rare type of small cell, and there has been little information in the scientific community. It appears to occur in only one or more lymph nodes, and nowhere else in the body. Treatment is similar to small cell lung cancer, but survival rates are much higher than other small-cell
552:
Chest radiation helps SCLC patients live longer by killing cancer cells and helping prevention of cancer recurrence. Another type of radiation, prophylactic cranial radiation, prevents central nervous system recurrence and can improve survival in patients with good performance status who have had a
291:
Small-cell carcinoma of the lung usually presents in the central airways and infiltrates the submucosa leading to narrowing of bronchial airways. Common symptoms include cough, dyspnea, weight loss, and debility. Over 70% of patients with small-cell carcinoma present with metastatic disease; common
492:
may be useful in the treatment of cisplatin-resistant cancer. About 68.1% of cisplatin-resistant cells appear to be sensitive to paclitaxel and 66.7% of paclitaxel-resistant cells to cisplatin. The mechanism for this activity is unknown. Paclitaxel-based chemotherapy showed modest activity in SCLC
708:
Long-term survival of more than 5 years can be achieved with proper treatment. According to the 17th World
Conference on Lung Cancer (WCLC), "patients who received chest radiation and prophylactic cranial irradiation along with a mean of five chemotherapy cycles could achieve a median survival of
3087:
983:
245:
Very rarely, the primary site for small-cell carcinoma is outside of the lungs and pleural space; in these cases, it is referred to as extrapulmonary small-cell carcinoma (EPSCC). Outside of the respiratory tract, small-cell carcinoma can appear in the cervix, prostate, liver, pancreas,
411:. Chest radiotherapy has been shown to improve survival in LS-SCLC. Because SCLC usually metastasizes widely very early on in the natural history of the tumor, and because nearly all cases respond dramatically to chemotherapy and/or radiotherapy, there has been little role for
446:, and the vast majority having at least some objective response. Responses in ES-SCLC are often of short duration, and the evidence surrounding the risk of treatment compared to the potential benefit of chemotherapy for people who have extensive SCLC is not clear.
382:
composed of primitive-appearing cells. As the name implies, the cells in small-cell carcinomas are smaller than normal cells, and barely have room for any cytoplasm. Some researchers identify this as a failure in the mechanism that controls the size of the cells.
778:
705:, and in particular, regimens based on platinum-containing agents. However, most people with the disease relapse and median survival remains low. The overall incidence and mortality rates of SCLC in the United States have decreased during the past few decades.
748:, which mandated increased attention to certain recalcitrant cancers (cancers having a 5-year relative survival rate of less than 50%), including small cell lung cancer. That led to the National Cancer Institute supporting small cell–specific research.
191:
Lung cancer is the leading cause of cancer-related deaths worldwide, accounting for the highest mortality rates among both men and women. When associated with the lung, SCLC is sometimes called "oat cell carcinoma" due to the flat cell shape and scanty
1271:
Pelosi G, Sonzogni A, Galetta D, Perrone F, Braidotti P, Manzotti M, et al. (April 2011). "Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type".
2553:
596:
Guidelines recommended as of 2018 that patients who relapse > 6 months from initial therapy should be retreated with the original chemotherapy regimen. For patients who relapse in < 6 months, single-agent chemotherapy either
2339:
150:
rate (combined limited and extensive SCLC) is 3.5% (4.3% for women, 2.8% for men). Survival can be higher or lower based on a combination of factors including stage, age, sex and race. While all lung cancers are associated with
683:
for small cell lung cancer (extensive and limited) range between 3.6% and 32.2% for women, and between 2.2% and 24.5% for men. Relative 5-year survival rate for both sexes has increased from 3.6% in 1975 to 6.7% in 2014. In
790:
688:
disease, relative 5-year survival rate (both sexes, all races, all ages) is 21.3%; however, women have higher 5-year survival rates, 26.9%, and men have lower survival rates, 21.3%. The prognosis is far grimmer in
2819:
2889:"ATLANTIS: a Phase III study of lurbinectedin/doxorubicin versus topotecan or cyclophosphamide/doxorubicin/vincristine in patients with small-cell lung cancer who have failed one prior platinum-containing line"
693:
small-cell lung carcinoma where 5-year relative survival rate (both sexes, all races, all ages) is 2.8%; however, women have higher 5-year survival rates, 3.4%, and men have lower 5-year survival rates, 2.2%.
2783:
Paz-Ares LG, Trigo Perez JM, Besse B, Moreno V, Lopez R, Sala MA, et al. (2019). "Efficacy and safety profile of lurbinectedin in second-line SCLC patients: Results from a phase II single-agent trial".
736:
Small cell lung carcinoma stand for 15% of lung cancers in the United States. Small cell lung cancer occurs almost exclusively in smokers – most commonly in heavy smokers and rarely in non-smokers.
814:
312:
544:
Canadian regulator rejected funding
Tecentriq (Atezolizumab) for extensive stage small-cell lung cancer in 2020 "as too costly" followed by United Kingdom also citing "drug’s cost-effectiveness."
415:
in this disease since the 1970s. However, in cases of small, asymptomatic, node-negative SCLC's ("very limited stage"), surgical excision may improve survival when used prior to chemotherapy.
323:
linked to small-cell carcinoma. Approximately half of all individuals diagnosed with
Lambert–Eaton myasthenic syndrome will eventually be found to have a small-cell carcinoma of the lung.
2513:
346:
amplifications and amplification of MYC family members are found in 30% of SCLCs. Loss of heterozygocity on chromosome arm 3p is found in more than 80% of SCLCs, including the loss of
1979:
3088:"Small cell carcinoma of the Lung and Bronchus SEER Relative Survival Rates by Time Since Diagnosis, 2004-2017 By Stage at Diagnosis, Male, All Races (includes Hispanic), All Ages"
207:(and hence staged differently). There is usually early involvement of the hilar and mediastinal lymph nodes. The mechanisms of its metastatic progression are not well understood.
3484:
1957:
2647:
Mouri A, Yamaguchi O, Miyauchi S, Shiono A, Utsugi H, Nishihara F, et al. (January 2019). "Combination therapy with carboplatin and paclitaxel for small cell lung cancer".
180:, and whether or not the entire tumor burden within the chest can feasibly be encompassed within a single radiotherapy portal. In general, if the tumor is confined to one
4358:
2938:"Myelopreservation with the CDK4/6 inhibitor trilaciclib in patients with small-cell lung cancer receiving first-line chemotherapy: a phase Ib/randomized phase II trial"
2361:
2597:
4566:
1864:
4216:
4740:
4735:
3580:
3067:"Table 15.13: Small Cell Cancer of the Lung and Bronchus (Invasive), 5-Year Relative and Period Survival by Race, Sex, Diagnosis Year, Age and Stage at Diagnosis"
4373:
2495:
632:
in relapsed small-cell lung cancer yielded an overall response rate of 41.7%, median progression-free survival 4.2 months, and overall survival was 8.5 months.
1782:
3037:
3161:
2629:
1246:
834:"Advanced small cell carcinoma of the uterine cervix treated by neoadjuvant chemotherapy with irinotecan and cisplatin followed by radical surgery"
4347:
2611:
400:
169:
2554:"FDA approves Imdelltra (tarlatamab-dlle), the first and only T-cell engager therapy for the treatment of extensive-stage small cell lung cancer"
2340:"Jazz Pharmaceuticals Announces U.S. FDA Accelerated Approval of Zepzelca (lurbinectedin) for the Treatment of Metastatic Small Cell Lung Cancer"
638:
showed increased overall survival rate in relapsed small cell lung cancer in a trial. Lurbinectedin is As of 2019 available in the U.S. under an
3179:
316:
4393:
1240:
1151:
1123:
1002:"Small cell carcinoma of the Lung and Bronchus SEER 5-Year Relative Survival Rates, 2011-2017 By Sex and Race/Ethnicity, Ages 50-64, Distant"
1999:
4833:
4559:
2987:
1142:
Mitchell, Richard
Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson (2007). "Ch. 13, box on morphology of small-cell lung carcinoma".
4600:
819:
4747:
4338:
4209:
4055:
222:
143:, small cell carcinoma is more aggressive, with a shorter doubling time, higher growth fraction, and earlier development of metastases.
3448:
3197:
2575:
4411:
4368:
3624:
3573:
3263:
230:
216:
2284:
442:. Response rates are high even in extensive disease, with between 15% and 30% of subjects having a complete response to combination
3356:
2459:
3066:
4388:
4105:
2838:"Antitumor activity of lurbinectedin (PM01183) and doxorubicin in relapsed small-cell lung cancer: results from a phase I study"
2313:
4780:
4552:
4109:
3942:
1808:
1317:"A combined small cell carcinoma of the lung containing three components: small cell, spindle cell and squamous cell carcinoma"
4610:
2237:"Paclitaxel as third-line chemotherapy for small cell lung cancer failing both etoposide- and camptothecin-based chemotherapy"
366:
4202:
3730:
2820:"PharmaMar and Bionical Emas Launch Expanded Access Program for Lurbinectedin in Relapsed Small Cell Lung Cancer in the U.S."
1914:
561:
If small cell lung cancer comes back after treatment, the following combination of drugs may be used as a salvage therapy:
358:
271:(approximately 1% of prostate cancers). Symptomatic metastasis of SCCP to the brain is rare, and carries a poor prognosis.
4330:
4047:
3566:
2441:
204:
140:
621:, have activity in relapsed SCLC. Of note, temozolomide yielded a response rate of 38% for brain metastases due to SCLC.
3836:
2519:
2407:
2401:
2367:
2290:
656:
4757:
4659:
4267:
4094:
4011:
3644:
745:
709:
more than 5 years." In some cases, long-term survival of 10+ years is achieved with chemotherapy and radiation alone.
304:
1830:
237:, including extremely complex malignant tissue admixtures. C-SCLC is the only currently recognized subtype of SCLC.
4343:
4151:
4133:
4043:
3994:
3423:
537:
233:(c-SCLC). Small-cell lung carcinoma can occur in combination with a wide variety of other histological variants of
226:
196:. Small cell mesothelioma – an extremely rare subtype of lung cancer – can be mistaken for small cell lung cancer.
4802:
4466:
4353:
4128:
4051:
3888:
3714:
3677:
1953:
527:
517:
4797:
4383:
4284:
4262:
4156:
4089:
4024:
3898:
3878:
3845:
3823:
3785:
3495:
2887:
Farago AF, Drapkin BJ, Lopez-Vilarino de Ramos JA, Galmarini CM, Núñez R, Kahatt C, Paz-Ares L (January 2019).
1774:
404:
1227:
4378:
4294:
4237:
3634:
3105:
2069:
Mountain CF (September 1978). "Clinical biology of small cell carcinoma: relationship to surgical therapy".
639:
320:
2477:
4843:
4828:
4684:
4515:
4017:
3841:
3781:
1114:
Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005).
136:
4363:
4250:
4179:
3903:
3162:"Focus on immunotherapy and patient perspective highlight the IASLC 2019 Small Cell Lung Cancer Meeting"
308:
247:
188:
close to that lung, the cancer is said to be LS. If cancer has spread beyond that, it is said to be ES.
3320:
Muscat JE, Wynder EL (January 1995). "Lung cancer pathology in smokers, ex-smokers and never smokers".
1723:
Titulaer MJ, Verschuuren JJ (2008). "Lambert-Eaton myasthenic syndrome: tumor versus nontumor forms".
52:
4838:
4007:
3866:
3803:
3639:
2187:"A systematic review of platinum and taxane resistance from bench to clinic: an inverse relationship"
1945:
1732:
680:
728:
Pie chart showing incidence of small-cell lung cancer (shown in red at right), as compared to other
4679:
4654:
4615:
4481:
4143:
3795:
3629:
2936:
Weiss JM, Csoszi T, Maglakelidze M, Hoyer RJ, Beck JT, Domine Gomez M, et al. (October 2019).
2186:
1068:
Argiris A, Murren JR (2001). "Staging and clinical prognostic factors for small-cell lung cancer".
296:
168:
Small-cell lung carcinoma (SCLC) has long been divided into two clinicopathological stages, termed
103:
3092:
Surveillance, Epidemiology, and End
Results (SEER) Relative Survival Rates by Time Since Diagnosis
1846:
1450:"Extrapulmonary small cell carcinoma localized in lymph nodes: is it a different clinical entity?"
1006:
Surveillance, Epidemiology, and End
Results (SEER) Relative Survival Rates by Time Since Diagnosis
988:
Surveillance, Epidemiology, and End
Results (SEER) Relative Survival Rates by Time Since Diagnosis
881:
Capizzello A, Peponi E, Simou N, Ntaskagiannis D, Tasiou I, Kamina S, Tsekeris P (February 2011).
4823:
4792:
4620:
4533:
4303:
3976:
3808:
3771:
3649:
3205:
2801:
2672:
2235:
Kim SH, Kim MJ, Kim YJ, Chang H, Kim JW, Lee JO, Lee KW, Kim JH, Bang SM, Lee JS (October 2017).
1756:
1702:
1297:
965:
553:
complete response or a very good partial response to chemoradiation in LD or chemotherapy in ED.
76:
4787:
3667:
2598:"NICE Cites Cost in Deciding Against Atezolizumab for Frontline Advanced Small Cell Lung Cancer"
763:
2836:
Calvo E, Moreno V, Flynn M, Holgado E, Olmedo ME, Lopez Criado MP, et al. (October 2017).
2514:"FDA grants accelerated approval to tarlatamab-dlle for extensive stage small cell lung cancer"
652:, reduces chemotheraphy-induced toxicity in patients being treated for small-cell lung cancer.
497:
is active in relapsed SCLC and was approved for medical use in the United States in June 2020.
172:(LS) and extensive stage (ES). The stage is generally determined by the presence or absence of
4591:
4581:
4440:
4229:
4120:
3535:
3405:
3337:
3302:
3259:
3235:
2969:
2918:
2869:
2765:
2716:
2664:
2266:
2217:
2167:
2119:
2078:
2051:
1991:
1896:
1858:
1748:
1694:
1659:
1610:
1579:
Nakazawa K, Kurishima K, Tamura T, Kagohashi K, Ishikawa H, Satoh H, Hizawa N (October 2012).
1561:
1520:
1471:
1389:
1338:
1289:
1236:
1203:
1147:
1119:
1077:
1050:
942:
912:
863:
832:
Nasu K, Hirakawa T, Okamoto M, Nishida M, Kiyoshima C, Matsumoto H, et al. (March 2011).
412:
147:
92:
2496:"Concurrent Tecentriq Adds First Survival Benefit Seen in Small Cell Lung Cancer in 20 Years"
1544:
The
Canadian Journal of Neurological Sciences. Le Journal Canadien des Sciences Neurologiques
4279:
4081:
3999:
3813:
3725:
3395:
3387:
3329:
3292:
3225:
3217:
2959:
2949:
2908:
2900:
2859:
2849:
2793:
2755:
2747:
2734:
Farago AF, Yeap BY, Stanzione M, Hung YP, Heist RS, Marcoux JP, et al. (October 2019).
2706:
2656:
2583:
2256:
2248:
2209:
2201:
2157:
2149:
2109:
2041:
2033:
1888:
1740:
1686:
1649:
1641:
1600:
1592:
1551:
1510:
1502:
1461:
1379:
1369:
1328:
1281:
1193:
1188:
1183:
1040:
1032:
902:
894:
853:
845:
713:
664:
565:
493:
patients refractory to both etoposide- and camptothecin-based chemotherapy. The newer agent
431:
68:
3374:
Augert A, Eastwood E, Ibrahim AH, Wu N, Grunblatt E, Basom R, et al. (February 2019).
724:
4722:
4699:
4671:
4641:
4632:
4099:
3762:
1424:
760:, perhaps best known as an actor on Saved by the Bell, died one month after the diagnosis.
506:
300:
268:
152:
4544:
4194:
3850:
1407:
370:
Histopathologic image of small-cell carcinoma of the lung. CT-guided core needle biopsy.
146:
Extensive stage small cell lung cancer (SCLC) is classified as a rare disorder. Ten-year
17:
2162:
2141:
2037:
1736:
1036:
796:
Histopathologic image of small-cell carcinoma of the lung. CT-guided core needle biopsy.
4730:
4689:
4461:
4311:
3776:
3705:
3489:
3400:
3375:
3230:
3012:
2964:
2937:
2913:
2888:
2864:
2837:
2760:
2735:
2261:
2236:
2046:
2021:
1654:
1629:
1605:
1580:
1515:
1490:
1384:
1357:
1198:
1171:
1045:
1020:
907:
882:
858:
833:
757:
2797:
4817:
4775:
4767:
4471:
3333:
3073:. Surveillance, Epidemiology, and End Results (SEER), U.S. National Cancer Institute.
2805:
2540:
2428:
2388:
649:
635:
494:
2695:"Treatment Options for Relapsed Small-Cell Lung Cancer: What Progress Have We Made?"
2676:
1760:
1706:
1301:
1096:
4507:
4245:
4034:
3986:
3930:
3831:
3546:
3206:"Comparison of aspects of smoking among the four histological types of lung cancer"
2153:
1879:
Leslie M (November 2011). "Mysteries of the cell. How does a cell know its size?".
702:
698:
668:
629:
618:
614:
523:
455:
443:
408:
80:
3558:
1892:
371:
3500:
3196:
Smokers defined as current or former smoker of more than 1 year of duration. See
2751:
2660:
2114:
2097:
221:
When SCLC is found with one or more differentiated forms of lung cancer, such as
4525:
4321:
4257:
3972:
3747:
3659:
3530:
2252:
1333:
1316:
883:"Pure small cell carcinoma of the prostate: a case report and literature review"
729:
660:
645:
577:
571:
472:
439:
435:
339:
284:
279:
234:
84:
2205:
2142:"Chemotherapy versus best supportive care for extensive small cell lung cancer"
1804:
1506:
934:
4476:
3883:
3752:
3742:
3598:
3391:
3376:"Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition"
3124:
1556:
1539:
1466:
1449:
1285:
602:
589:
583:
533:
489:
200:
185:
173:
60:
3297:
3280:
2140:
Pelayo
Alvarez M, Westeel V, Cortés-Jofré M, Bonfill Cosp X (November 2013).
1690:
784:
Anaplastic (microcellular, oat cell) carcinoma from the lung (histopathology)
423:
In ES-SCLC, platinum-based combination chemotherapy is the standard of care.
4512:
4422:
3935:
3871:
3611:
3607:
3541:
3506:
3180:"SCLC Prognosis Remains 'Unsatisfactory' Despite Numerous Treatment Options"
3038:"FDA Approves Drug to Reduce Bone Marrow Suppression Caused by Chemotherapy"
2954:
2854:
2098:"Surgery for limited stage small cell lung cancer: time to fish or cut bait"
2022:"Consolidative radiation therapy for extensive-stage small cell lung cancer"
1744:
1645:
1412:
598:
513:
476:
466:
462:
458:
in a combination of two drugs, which is more effective than one drug alone.
427:
193:
117:
72:
3409:
3306:
3239:
3221:
2973:
2922:
2873:
2769:
2720:
2668:
2270:
2221:
2171:
2123:
2055:
1995:
1900:
1752:
1698:
1663:
1614:
1565:
1475:
1393:
1374:
1342:
1293:
1207:
1081:
1054:
946:
916:
867:
3511:
3341:
2904:
2736:"Combination Olaparib and Temozolomide in Relapsed Small-Cell Lung Cancer"
2612:"Study: Chest Radiation Helps Small Cell Lung Cancer Patients Live Longer"
1540:"Brain metastasis from prostate small cell carcinoma: not to be neglected"
1524:
4704:
4694:
4649:
4577:
4445:
4435:
3143:
2711:
2694:
2082:
1922:
1235:. World Health Organization Classification of Tumours. Lyon: IARC Press.
625:
426:
Combination chemotherapy consists of a wide variety of agents, including
379:
132:
97:
1805:"Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer"
1596:
732:
types, with fractions of smokers versus non-smokers shown for each type.
663:(Cosela) as a treatment to reduce the frequency of chemotherapy-induced
4430:
3893:
3700:
3672:
2988:"FDA Grants Priority Review to Trilaciclib to Treat Patients with SCLC"
2362:"FDA grants accelerated approval to lurbinectedin for metastatic small"
1229:
Pathology and
Genetics of Tumours of the Lung, Pleura, Thymus and Heart
849:
3476:
2478:"FDA approves atezolizumab for extensive-stage small cell lung cancer"
2314:"Zepzelca- lurbinectedin injection, powder, lyophilized, for solution"
898:
127:, although it can occasionally arise in other body sites, such as the
4499:
4274:
4225:
4170:
3963:
3757:
3590:
3204:
Kenfield SA, Wei EK, Stampfer MJ, Rosner BA, Colditz GA (June 2008).
2213:
1538:
Erasmus CE, Verhagen WI, Wauters CA, van Lindert EJ (November 2002).
1489:
Nutting C, Horwich A, Fisher C, Parsons C, Dearnaley DP (June 1997).
1226:
Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC, eds. (2004).
287:
showing a probable S2–S3 small cell carcinoma in the right side lung.
177:
128:
120:
386:
At the time of diagnosis, 60–70% of people already have metastases.
3013:"Trilaciclib | intravenous CDK4/6 inhibitor | G1 Therapeutics, Inc"
1822:
3691:
3166:
The International Association for the Study of Lung Cancer (IASLC)
1581:"Specific organ metastases and survival in small cell lung cancer"
365:
278:
2539:
This article incorporates text from this source, which is in the
2427:
This article incorporates text from this source, which is in the
2387:
This article incorporates text from this source, which is in the
1823:"Atlas of Genetics and Cytogenetics in Oncology and Haematology"
1677:
Babar SM (October 2013). "SIADH associated with ciprofloxacin".
1358:"A rare bladder cancer--small cell carcinoma: review and update"
766:, Danish football player, died three months after the diagnosis.
347:
331:
254:
Extrapulmonary small-cell carcinoma localized in the lymph nodes
181:
124:
64:
4548:
4198:
3562:
2576:"Canadian regulator considers changes to new drug pricing plan"
1980:"Limited small-cell lung cancer: a potentially curable disease"
362:
Histopathology of small-cell carcinoma, with typical findings.
343:
338:
and the retinoblastoma pathway are inactivated in most SCLCs.
335:
267:
Small-cell carcinoma of the prostate (SCCP) is a rare form of
313:
syndrome of inappropriate antidiuretic hormone hypersecretion
3281:"Changing face of small-cell lung cancer: real and artifact"
2460:"FDA Approves Opdivo (Nivolumab) for Small Cell Lung Cancer"
229:, the malignant tumor is then diagnosed and classified as a
1315:
Gotoh M, Yamamoto Y, Huang CL, Yokomise H (November 2004).
311:(ADH). Ectopic production of large amounts of ADH leads to
199:
Small-cell carcinoma is most often more rapidly and widely
2442:"FDA Approves Opdivo for Small Cell Lung Cancer Treatment"
1915:"Limited-stage small cell lung cancer: Initial management"
1845:
Caroline I.M. Underwood, M.D., Carolyn Glass, M.D., Ph.D.
350:. One hundred translocations have been reported in SCLCs.
3258:. World Health Organization. 2014. pp. Chapter 5.1.
155:, SCLC is very strongly associated with tobacco smoking.
1448:
Cicin I, Usta U, Karagol H, Uzunoglu S, Kocak Z (2009).
716:
is about 1 year, the worst of any lung cancer subtype.
3424:"Dustin Diamond, 'Saved by the Bell' Star, Dead at 44"
1978:
Sherman CA, Rocha Lima CM, Turrisi AT (October 2000).
1718:
1716:
1958:
United States Department of Health and Human Services
454:
Small-cell lung cancer is most commonly treated with
3466:
3125:"Exceptional SCLC Survivors: 5-Year Median Survival"
1843:
Image by Mikael Häggström, MD. Source for findings:
4766:
4721:
4670:
4640:
4631:
4599:
4590:
4524:
4498:
4454:
4420:
4402:
4329:
4320:
4302:
4293:
4236:
4169:
4142:
4119:
4080:
4069:
4033:
3985:
3962:
3951:
3916:
3859:
3822:
3794:
3713:
3699:
3690:
3658:
3606:
3597:
3521:
3470:
3144:"Lung cancer report: "They said it was bronchitis""
2342:(Press release). Jazz Pharmaceuticals. 15 June 2020
1172:"Investigating Tumor Heterogeneity in Mouse Models"
624:In a clinical trial of 50 patients, combination of
91:
40:
35:
176:, whether or not the tumor appears limited to the
1630:"Mechanisms of small cell lung cancer metastasis"
1118:. St. Louis, Mo: Elsevier Saunders. p. 759.
1021:"Chemotherapy advances in small-cell lung cancer"
3082:
3080:
3061:
3059:
3057:
2185:Stordal B, Pavlakis N, Davey R (December 2007).
1940:
1938:
292:sites include liver, adrenals, bone, and brain.
2825:(Press release) – via www.prnewswire.com.
2135:
2133:
984:"Small cell carcinoma of the Lung and Bronchus"
941:, Treasure Island (FL): StatPearls Publishing,
407:is administered together with concurrent chest
4736:High-grade prostatic intraepithelial neoplasia
1775:"Lung: Translocations in Small Cell Carcinoma"
1116:Robbins and Cotran pathologic basis of disease
4560:
4210:
3574:
8:
1863:: CS1 maint: multiple names: authors list (
1137:
1135:
671:for extensive-stage small-cell lung cancer.
378:Small-cell carcinoma is an undifferentiated
3071:The SEER Cancer Statistics Review 1975-2015
2146:The Cochrane Database of Systematic Reviews
1321:European Journal of Cardio-Thoracic Surgery
697:Small-cell carcinoma is very responsive to
4637:
4596:
4567:
4553:
4545:
4326:
4299:
4217:
4203:
4195:
4077:
3959:
3710:
3696:
3603:
3581:
3567:
3559:
3467:
2688:
2686:
1725:Annals of the New York Academy of Sciences
1221:
1219:
1217:
1165:
1163:
102:
51:
32:
3399:
3296:
3229:
3036:Office of the Commissioner (2021-02-12).
2963:
2953:
2912:
2863:
2853:
2759:
2710:
2260:
2161:
2113:
2045:
1990:(10): 1395–403, discussion 1403–4, 1409.
1653:
1628:Ko J, Winslow MM, Sage J (January 2021).
1604:
1555:
1514:
1465:
1383:
1373:
1332:
1197:
1187:
1044:
933:Basumallik, Neil; Agarwal, Manuj (2023),
906:
857:
1495:Journal of the Royal Society of Medicine
1146:(8th ed.). Philadelphia: Saunders.
970:National Organization for Rare Disorders
723:
667:for patients receiving certain types of
357:
3357:"A new focus on small cell lung cancer"
3200:for percentages in numbers. Reference:
3094:. U.S. National Cancer Institute. 2016.
1189:10.1146/annurev-cancerbio-030419-033413
1008:. U.S. National Cancer Institute. 2016.
990:. U.S. National Cancer Institute. 2016.
807:
774:
3279:Ettinger DS, Aisner J (October 2006).
2630:"Treatment for Small Cell Lung Cancer"
1856:
1491:"Small-cell carcinoma of the prostate"
712:A 2023 article stated that the median
4394:Basaloid squamous cell lung carcinoma
1869:Last author update: 20 September 2022
123:that most commonly arises within the
7:
1785:from the original on 30 January 2015
928:
926:
744:In 2013, the US Congress passed the
299:, small-cell carcinomas can produce
263:Small-cell carcinoma of the prostate
4748:List of people with prostate cancer
4056:Papillary serous cystadenocarcinoma
2693:Qin A, Kalemkerian GP (June 2018).
2556:(Press release). Amgen. 16 May 2024
2038:10.3978/j.issn.2218-6751.2015.04.02
1408:Extrapulmonary Small Cell Carcinoma
1252:from the original on 23 August 2009
1037:10.3978/j.issn.2072-1439.2013.07.43
1019:Chan BA, Coward JI (October 2013).
241:Extrapulmonary small-cell carcinoma
3625:Combined small-cell lung carcinoma
3106:"Small Cell Lung Cancer Treatment"
2582:. 20 February 2020. Archived from
2026:Translational Lung Cancer Research
1946:"Small Cell Lung Cancer Treatment"
334:is mutated in 70 to 90% of SCLCs.
231:combined small cell lung carcinoma
217:Combined small-cell lung carcinoma
211:Combined small-cell lung carcinoma
25:
2798:10.1200/JCO.2019.37.15_suppl.8506
2482:U.S. Food and Drug Administration
2402:"Drug Trials Snapshots: Zepzelca"
1362:Orphanet Journal of Rare Diseases
317:Lambert–Eaton myasthenic syndrome
63:of a small-cell carcinoma of the
3123:Davenport L (20 December 2016).
2534:
2422:
2382:
1833:from the original on 2011-02-23.
1811:from the original on 2016-05-29.
1170:Tammela T, Sage J (March 2020).
789:
777:
746:Recalcitrant Cancer Research Act
613:Several newer agents, including
3943:Syringocystadenoma papilliferum
3459:] (in Danish). 9 July 2023.
3142:Ketteler J (October 16, 2009).
1176:Annual Review of Cancer Biology
3731:Familial adenomatous polyposis
3355:Richards S (7 February 2019).
2285:"Zepzelca: FDA-Approved Drugs"
2154:10.1002/14651858.CD001990.pub3
2020:Singer L, Yom SS (June 2015).
159:Types of small-cell carcinomas
1:
4752:
4412:Combined small-cell carcinoma
4374:Salivary gland–like carcinoma
4331:Non-small-cell lung carcinoma
4106:Paget's disease of the breast
4048:Pancreatic serous cystadenoma
2096:Shepherd FA (February 2010).
1893:10.1126/science.334.6059.1047
1847:"Lung - Small cell carcinoma"
1679:The Annals of Pharmacotherapy
205:non-small-cell lung carcinoma
4781:Extramammary Paget's disease
4110:Extramammary Paget's disease
3837:Multiple endocrine neoplasia
3334:10.1016/0304-3835(94)03608-l
3285:Journal of Clinical Oncology
2786:Journal of Clinical Oncology
2752:10.1158/2159-8290.CD-19-0582
2699:Journal of Oncology Practice
2661:10.1016/j.resinv.2018.09.004
2520:Food and Drug Administration
2408:Food and Drug Administration
2368:Food and Drug Administration
2291:Food and Drug Administration
2115:10.1097/JTO.0b013e3181c8cbf5
2102:Journal of Thoracic Oncology
820:Dorland's Medical Dictionary
509:for small cell lung cancer:
4834:Infectious causes of cancer
4758:Transitional-cell carcinoma
4660:Germ cell neoplasia in situ
4348:Mucinous cystadenocarcinoma
4268:Nasopharyngeal angiofibroma
4095:Pancreatic ductal carcinoma
4012:Mucinous cystadenocarcinoma
3645:Transitional cell carcinoma
2253:10.1097/MD.0000000000008176
1356:Ismaili N (November 2011).
1334:10.1016/j.ejcts.2004.08.002
1025:Journal of Thoracic Disease
505:The FDA has approved three
305:adrenocorticotropic hormone
4860:
4611:Sertoli–Leydig cell tumour
4152:Medullary breast carcinoma
4134:Invasive lobular carcinoma
4044:Ovarian serous cystadenoma
3995:Signet ring cell carcinoma
2792:(supl, abstr 8506): 8506.
2600:. Reuters. 6 January 2020.
2206:10.1016/j.ctrv.2007.07.013
1507:10.1177/014107689709000615
538:bi-specific T-cell engager
214:
4803:Hirsuties coronae glandis
4467:Solitary pulmonary nodule
4354:Large-cell lung carcinoma
4129:Lobular carcinoma in situ
4052:Serous cystadenocarcinoma
3889:Clear-cell adenocarcinoma
3678:Bartholin gland carcinoma
3589:Glandular and epithelial
3392:10.1126/scisignal.aau2922
3110:National Cancer Institute
2649:Respiratory Investigation
1954:National Cancer Institute
1950:National Cancer Institute
1827:atlasgeneticsoncology.org
1779:atlasgeneticsoncology.org
1557:10.1017/S0317167100002250
1467:10.1080/02841860802495370
1286:10.1007/s00428-010-1011-8
1097:"Small Cell Mesothelioma"
59:
50:
18:Small cell lung carcinoma
4798:Erythroplasia of Queyrat
4384:Papillary adenocarcinoma
4285:Laryngeal papillomatosis
4263:Nasopharyngeal carcinoma
4157:Medullary thyroid cancer
4090:Mammary ductal carcinoma
4025:Mucoepidermoid carcinoma
3879:Adenoid cystic carcinoma
3846:Adrenocortical carcinoma
3786:Hepatocellular carcinoma
3298:10.1200/jco.2006.07.3841
3256:World Cancer Report 2014
2564:– via PR Newswire.
2350:– via PR Newswire.
2194:Cancer Treatment Reviews
1691:10.1177/1060028013502457
966:"Small Cell Lung Cancer"
935:"Small Cell Lung Cancer"
887:Case Reports in Oncology
601:second-line therapy, or
405:combination chemotherapy
342:is mutated in 2 to 10%.
321:paraneoplastic condition
141:non-small cell carcinoma
44:Small-cell lung cancer,
27:Type of malignant cancer
4379:Adenosquamous carcinoma
4339:Squamous-cell carcinoma
3635:Squamous-cell carcinoma
2634:Canadian Cancer Society
1745:10.1196/annals.1405.030
1646:10.15252/emmm.202013122
1634:EMBO Molecular Medicine
1425:"Merkel-cell carcinima"
1144:Robbins Basic Pathology
1101:The Mesothelioma Center
640:expanded access program
223:squamous cell carcinoma
4685:Endodermal sinus tumor
4516:solitary fibrous tumor
4018:Pseudomyxoma peritonei
3842:Adrenocortical adenoma
3782:Hepatocellular adenoma
3222:10.1136/tc.2007.022582
3017:www.g1therapeutics.com
1375:10.1186/1750-1172-6-75
1031:(Suppl 5): S565–S578.
815:"small-cell carcinoma"
733:
375:
363:
295:Due to its high grade
288:
164:Small-cell lung cancer
137:gastrointestinal tract
4364:Sarcomatoid carcinoma
4251:Esthesioneuroblastoma
4180:Acinic cell carcinoma
3904:Papillary hidradenoma
3428:Entertainment Tonight
3198:image page in Commons
2955:10.1093/annonc/mdz278
2905:10.2217/fon-2018-0597
2855:10.1093/annonc/mdx357
2586:on February 22, 2020.
727:
681:5-year survival rates
369:
361:
309:anti-diuretic hormone
297:neuroendocrine nature
282:
248:Merkel-cell carcinoma
4753:Small-cell carcinoma
4404:Small-cell carcinoma
4389:Giant-cell carcinoma
4008:Mucinous cystadenoma
3867:Neuroendocrine tumor
3804:Renal cell carcinoma
3640:Basal-cell carcinoma
3620:Small-cell carcinoma
2712:10.1200/JOP.18.00278
2502:. 25 September 2018.
2071:Seminars in Oncology
568:(Cytoxan, Procytox),
484:Cisplatin-resistance
116:is a type of highly
114:Small-cell carcinoma
71:, minimal amount of
36:Small-cell carcinoma
4680:Embryonal carcinoma
4655:Spermatocytic tumor
4616:Sertoli cell tumour
4482:Bronchial leiomyoma
4144:Medullary carcinoma
3630:Verrucous carcinoma
1887:(6059): 1047–1048.
1737:2008NYASA1132..129T
1597:10.3892/ol.2012.792
67:showing cells with
4793:Bowenoid papulosis
4621:Leydig cell tumour
4534:Mediastinal tumors
4359:Rhabdoid carcinoma
3977:Cystadenocarcinoma
3809:Endometrioid tumor
3772:Cholangiocarcinoma
3660:Complex epithelial
3650:Inverted papilloma
3522:External resources
2942:Annals of Oncology
2842:Annals of Oncology
1851:Pathology Outlines
850:10.4081/rt.2011.e6
734:
557:In case of relapse
376:
364:
289:
275:Signs and symptoms
77:stippled chromatin
46:oat-cell carcinoma
4811:
4810:
4717:
4716:
4713:
4712:
4582:urogenital system
4542:
4541:
4494:
4493:
4490:
4489:
4441:Immature teratoma
4230:respiratory tract
4192:
4191:
4188:
4187:
4165:
4164:
4121:Lobular carcinoma
4065:
4064:
3912:
3911:
3686:
3685:
3556:
3555:
3512:11010461000119101
3449:"Asbjørn Sennels"
3386:(567): eaau2922.
3380:Science Signaling
3291:(28): 4526–4527.
2948:(10): 1613–1621.
2848:(10): 2559–2566.
2746:(10): 1372–1387.
2448:. 17 August 2018.
1685:(10): 1359–1363.
1242:978-92-832-2418-1
1153:978-1-4160-2973-1
1125:978-0-7216-0187-8
899:10.1159/000324717
771:Additional images
548:Radiation therapy
148:relative survival
111:
110:
30:Medical condition
16:(Redirected from
4851:
4638:
4597:
4569:
4562:
4555:
4546:
4327:
4300:
4280:Laryngeal cancer
4219:
4212:
4205:
4196:
4112:
4082:Ductal carcinoma
4078:
4058:
4014:
4000:Krukenberg tumor
3960:
3814:Renal oncocytoma
3726:Linitis plastica
3715:Gastrointestinal
3711:
3697:
3604:
3583:
3576:
3569:
3560:
3468:
3461:
3460:
3445:
3439:
3438:
3436:
3435:
3420:
3414:
3413:
3403:
3371:
3365:
3364:
3352:
3346:
3345:
3317:
3311:
3310:
3300:
3276:
3270:
3269:
3252:
3246:
3243:
3233:
3194:
3188:
3187:
3186:. 12 April 2023.
3176:
3170:
3169:
3158:
3152:
3151:
3139:
3133:
3132:
3120:
3114:
3113:
3102:
3096:
3095:
3084:
3075:
3074:
3063:
3052:
3051:
3049:
3048:
3033:
3027:
3026:
3024:
3023:
3009:
3003:
3002:
3000:
2999:
2994:. 17 August 2020
2984:
2978:
2977:
2967:
2957:
2933:
2927:
2926:
2916:
2884:
2878:
2877:
2867:
2857:
2833:
2827:
2826:
2816:
2810:
2809:
2780:
2774:
2773:
2763:
2740:Cancer Discovery
2731:
2725:
2724:
2714:
2690:
2681:
2680:
2644:
2638:
2637:
2626:
2620:
2619:
2608:
2602:
2601:
2594:
2588:
2587:
2572:
2566:
2565:
2563:
2561:
2550:
2544:
2538:
2537:
2533:
2531:
2529:
2510:
2504:
2503:
2492:
2486:
2485:
2474:
2468:
2467:
2456:
2450:
2449:
2438:
2432:
2426:
2425:
2421:
2419:
2417:
2398:
2392:
2386:
2385:
2381:
2379:
2377:
2358:
2352:
2351:
2349:
2347:
2336:
2330:
2329:
2327:
2325:
2310:
2304:
2303:
2301:
2299:
2281:
2275:
2274:
2264:
2232:
2226:
2225:
2191:
2182:
2176:
2175:
2165:
2148:(11): CD001990.
2137:
2128:
2127:
2117:
2093:
2087:
2086:
2066:
2060:
2059:
2049:
2017:
2011:
2010:
2008:
2007:
1998:. Archived from
1975:
1969:
1968:
1966:
1965:
1942:
1933:
1932:
1930:
1929:
1919:www.uptodate.com
1911:
1905:
1904:
1876:
1870:
1868:
1862:
1854:
1841:
1835:
1834:
1819:
1813:
1812:
1801:
1795:
1794:
1792:
1790:
1771:
1765:
1764:
1720:
1711:
1710:
1674:
1668:
1667:
1657:
1625:
1619:
1618:
1608:
1585:Oncology Letters
1576:
1570:
1569:
1559:
1535:
1529:
1528:
1518:
1486:
1480:
1479:
1469:
1445:
1439:
1438:
1436:
1435:
1421:
1415:
1404:
1398:
1397:
1387:
1377:
1353:
1347:
1346:
1336:
1327:(5): 1047–1049.
1312:
1306:
1305:
1268:
1262:
1261:
1259:
1257:
1251:
1234:
1223:
1212:
1211:
1201:
1191:
1167:
1158:
1157:
1139:
1130:
1129:
1111:
1105:
1104:
1092:
1086:
1085:
1065:
1059:
1058:
1048:
1016:
1010:
1009:
998:
992:
991:
980:
974:
973:
962:
956:
955:
954:
953:
930:
921:
920:
910:
878:
872:
871:
861:
829:
823:
812:
793:
781:
714:overall survival
665:myelosuppression
650:CKD4/6 inhibitor
574:(Adriamycin) and
566:Cyclophosphamide
432:cyclophosphamide
319:is a well-known
301:ectopic hormones
107:
106:
69:nuclear moulding
55:
33:
21:
4859:
4858:
4854:
4853:
4852:
4850:
4849:
4848:
4814:
4813:
4812:
4807:
4788:Bowen's disease
4762:
4709:
4700:Choriocarcinoma
4666:
4627:
4603:gonadal stromal
4602:
4586:
4573:
4543:
4538:
4520:
4486:
4477:Peripheral lung
4450:
4416:
4398:
4316:
4289:
4232:
4223:
4193:
4184:
4161:
4138:
4115:
4104:
4100:Comedocarcinoma
4073:
4071:
4061:
4042:
4029:
4006:
3981:
3955:
3953:
3947:
3918:
3908:
3855:
3818:
3790:
3763:Somatostatinoma
3706:adenocarcinomas
3704:
3682:
3668:Warthin's tumor
3654:
3593:
3587:
3557:
3552:
3551:
3517:
3516:
3479:
3465:
3464:
3447:
3446:
3442:
3433:
3431:
3430:. February 2021
3422:
3421:
3417:
3373:
3372:
3368:
3354:
3353:
3349:
3319:
3318:
3314:
3278:
3277:
3273:
3266:
3254:
3253:
3249:
3210:Tobacco Control
3203:
3195:
3191:
3178:
3177:
3173:
3160:
3159:
3155:
3141:
3140:
3136:
3122:
3121:
3117:
3104:
3103:
3099:
3086:
3085:
3078:
3065:
3064:
3055:
3046:
3044:
3035:
3034:
3030:
3021:
3019:
3011:
3010:
3006:
2997:
2995:
2986:
2985:
2981:
2935:
2934:
2930:
2893:Future Oncology
2886:
2885:
2881:
2835:
2834:
2830:
2818:
2817:
2813:
2782:
2781:
2777:
2733:
2732:
2728:
2692:
2691:
2684:
2646:
2645:
2641:
2628:
2627:
2623:
2610:
2609:
2605:
2596:
2595:
2591:
2574:
2573:
2569:
2559:
2557:
2552:
2551:
2547:
2535:
2527:
2525:
2512:
2511:
2507:
2494:
2493:
2489:
2476:
2475:
2471:
2458:
2457:
2453:
2440:
2439:
2435:
2423:
2415:
2413:
2400:
2399:
2395:
2383:
2375:
2373:
2360:
2359:
2355:
2345:
2343:
2338:
2337:
2333:
2323:
2321:
2312:
2311:
2307:
2297:
2295:
2283:
2282:
2278:
2234:
2233:
2229:
2189:
2184:
2183:
2179:
2139:
2138:
2131:
2095:
2094:
2090:
2068:
2067:
2063:
2019:
2018:
2014:
2005:
2003:
1977:
1976:
1972:
1963:
1961:
1944:
1943:
1936:
1927:
1925:
1913:
1912:
1908:
1878:
1877:
1873:
1855:
1844:
1842:
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1821:
1820:
1816:
1803:
1802:
1798:
1788:
1786:
1773:
1772:
1768:
1722:
1721:
1714:
1676:
1675:
1671:
1627:
1626:
1622:
1578:
1577:
1573:
1537:
1536:
1532:
1488:
1487:
1483:
1454:Acta Oncologica
1447:
1446:
1442:
1433:
1431:
1423:
1422:
1418:
1405:
1401:
1355:
1354:
1350:
1314:
1313:
1309:
1274:Virchows Archiv
1270:
1269:
1265:
1255:
1253:
1249:
1243:
1232:
1225:
1224:
1215:
1169:
1168:
1161:
1154:
1141:
1140:
1133:
1126:
1113:
1112:
1108:
1094:
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1067:
1066:
1062:
1018:
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1000:
999:
995:
982:
981:
977:
964:
963:
959:
951:
949:
932:
931:
924:
880:
879:
875:
831:
830:
826:
813:
809:
804:
797:
794:
785:
782:
773:
764:Asbjørn Sennels
754:
742:
722:
691:extensive-stage
677:
611:
559:
550:
528:PD-L1 inhibitor
526:(Tecentriq), a
507:immunotherapies
503:
486:
452:
421:
397:
392:
356:
329:
277:
269:prostate cancer
265:
256:
243:
219:
213:
166:
161:
153:tobacco smoking
101:
45:
31:
28:
23:
22:
15:
12:
11:
5:
4857:
4855:
4847:
4846:
4841:
4836:
4831:
4826:
4816:
4815:
4809:
4808:
4806:
4805:
4800:
4795:
4790:
4785:
4784:
4783:
4772:
4770:
4764:
4763:
4761:
4760:
4755:
4750:
4745:
4744:
4743:
4733:
4731:Adenocarcinoma
4727:
4725:
4719:
4718:
4715:
4714:
4711:
4710:
4708:
4707:
4702:
4697:
4692:
4690:Gonadoblastoma
4687:
4682:
4676:
4674:
4668:
4667:
4665:
4664:
4663:
4662:
4657:
4646:
4644:
4635:
4629:
4628:
4626:
4625:
4624:
4623:
4618:
4607:
4605:
4594:
4588:
4587:
4585:
4584:
4574:
4572:
4571:
4564:
4557:
4549:
4540:
4539:
4537:
4536:
4530:
4528:
4522:
4521:
4519:
4518:
4510:
4504:
4502:
4496:
4495:
4492:
4491:
4488:
4487:
4485:
4484:
4479:
4474:
4469:
4464:
4462:Pancoast tumor
4458:
4456:
4452:
4451:
4449:
4448:
4443:
4438:
4433:
4427:
4425:
4418:
4417:
4415:
4414:
4408:
4406:
4400:
4399:
4397:
4396:
4391:
4386:
4381:
4376:
4371:
4366:
4361:
4356:
4351:
4344:Adenocarcinoma
4341:
4335:
4333:
4324:
4318:
4317:
4315:
4314:
4312:Tracheal tumor
4308:
4306:
4297:
4291:
4290:
4288:
4287:
4282:
4277:
4271:
4270:
4265:
4260:
4254:
4253:
4248:
4242:
4240:
4234:
4233:
4228:involving the
4224:
4222:
4221:
4214:
4207:
4199:
4190:
4189:
4186:
4185:
4183:
4182:
4176:
4174:
4167:
4166:
4163:
4162:
4160:
4159:
4154:
4148:
4146:
4140:
4139:
4137:
4136:
4131:
4125:
4123:
4117:
4116:
4114:
4113:
4102:
4097:
4092:
4086:
4084:
4075:
4067:
4066:
4063:
4062:
4060:
4059:
4039:
4037:
4031:
4030:
4028:
4027:
4022:
4021:
4020:
4004:
4003:
4002:
3991:
3989:
3983:
3982:
3980:
3979:
3969:
3967:
3957:
3949:
3948:
3946:
3945:
3940:
3939:
3938:
3933:
3922:
3920:
3919:skin appendage
3914:
3913:
3910:
3909:
3907:
3906:
3901:
3896:
3891:
3886:
3881:
3876:
3875:
3874:
3863:
3861:
3860:Other/multiple
3857:
3856:
3854:
3853:
3848:
3839:
3834:
3828:
3826:
3820:
3819:
3817:
3816:
3811:
3806:
3800:
3798:
3792:
3791:
3789:
3788:
3779:
3777:Klatskin tumor
3774:
3768:
3767:
3766:
3765:
3760:
3755:
3750:
3745:
3734:
3733:
3728:
3719:
3717:
3708:
3694:
3688:
3687:
3684:
3683:
3681:
3680:
3675:
3670:
3664:
3662:
3656:
3655:
3653:
3652:
3647:
3642:
3637:
3632:
3627:
3622:
3616:
3614:
3601:
3595:
3594:
3588:
3586:
3585:
3578:
3571:
3563:
3554:
3553:
3550:
3549:
3538:
3526:
3525:
3523:
3519:
3518:
3515:
3514:
3503:
3492:
3480:
3475:
3474:
3472:
3471:Classification
3463:
3462:
3457:Extra Magazine
3440:
3415:
3366:
3347:
3322:Cancer Letters
3312:
3271:
3265:978-9283204299
3264:
3247:
3245:
3244:
3216:(3): 198–204.
3189:
3184:Cancer Network
3171:
3153:
3134:
3115:
3097:
3076:
3053:
3028:
3004:
2992:Cancer Network
2979:
2928:
2899:(3): 231–239.
2879:
2828:
2811:
2775:
2726:
2705:(6): 369–370.
2682:
2639:
2621:
2603:
2589:
2567:
2545:
2505:
2487:
2469:
2451:
2433:
2412:. 15 June 2020
2393:
2372:. 15 June 2020
2353:
2331:
2320:. 15 June 2020
2305:
2276:
2227:
2200:(8): 688–703.
2177:
2129:
2108:(2): 147–149.
2088:
2077:(3): 272–279.
2061:
2032:(3): 211–214.
2012:
1970:
1934:
1906:
1871:
1836:
1814:
1796:
1766:
1731:(1): 129–134.
1712:
1669:
1620:
1591:(4): 617–620.
1571:
1550:(4): 375–377.
1530:
1501:(6): 340–341.
1481:
1460:(3): 354–360.
1440:
1416:
1399:
1348:
1307:
1280:(4): 497–503.
1263:
1241:
1213:
1159:
1152:
1131:
1124:
1106:
1087:
1076:(5): 437–447.
1070:Cancer Journal
1060:
1011:
993:
975:
957:
922:
873:
824:
806:
805:
803:
800:
799:
798:
795:
788:
786:
783:
776:
772:
769:
768:
767:
761:
758:Dustin Diamond
753:
750:
741:
738:
721:
718:
676:
673:
610:
607:
594:
593:
587:
581:
575:
569:
558:
555:
549:
546:
542:
541:
531:
521:
518:PD-1 inhibitor
502:
499:
485:
482:
481:
480:
470:
451:
448:
420:
417:
396:
393:
391:
388:
355:
352:
328:
325:
283:Frontal chest
276:
273:
264:
261:
255:
252:
242:
239:
227:adenocarcinoma
215:Main article:
212:
209:
165:
162:
160:
157:
139:. Compared to
109:
108:
95:
89:
88:
57:
56:
48:
47:
42:
38:
37:
29:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
4856:
4845:
4844:Rare diseases
4842:
4840:
4837:
4835:
4832:
4830:
4829:Cytopathology
4827:
4825:
4822:
4821:
4819:
4804:
4801:
4799:
4796:
4794:
4791:
4789:
4786:
4782:
4779:
4778:
4777:
4774:
4773:
4771:
4769:
4765:
4759:
4756:
4754:
4751:
4749:
4746:
4742:
4739:
4738:
4737:
4734:
4732:
4729:
4728:
4726:
4724:
4720:
4706:
4703:
4701:
4698:
4696:
4693:
4691:
4688:
4686:
4683:
4681:
4678:
4677:
4675:
4673:
4669:
4661:
4658:
4656:
4653:
4652:
4651:
4648:
4647:
4645:
4643:
4639:
4636:
4634:
4630:
4622:
4619:
4617:
4614:
4613:
4612:
4609:
4608:
4606:
4604:
4598:
4595:
4593:
4589:
4583:
4579:
4576:
4575:
4570:
4565:
4563:
4558:
4556:
4551:
4550:
4547:
4535:
4532:
4531:
4529:
4527:
4523:
4517:
4514:
4511:
4509:
4506:
4505:
4503:
4501:
4497:
4483:
4480:
4478:
4475:
4473:
4470:
4468:
4465:
4463:
4460:
4459:
4457:
4453:
4447:
4444:
4442:
4439:
4437:
4434:
4432:
4429:
4428:
4426:
4424:
4419:
4413:
4410:
4409:
4407:
4405:
4401:
4395:
4392:
4390:
4387:
4385:
4382:
4380:
4377:
4375:
4372:
4370:
4367:
4365:
4362:
4360:
4357:
4355:
4352:
4349:
4345:
4342:
4340:
4337:
4336:
4334:
4332:
4328:
4325:
4323:
4319:
4313:
4310:
4309:
4307:
4305:
4301:
4298:
4296:
4292:
4286:
4283:
4281:
4278:
4276:
4273:
4272:
4269:
4266:
4264:
4261:
4259:
4256:
4255:
4252:
4249:
4247:
4244:
4243:
4241:
4239:
4235:
4231:
4227:
4220:
4215:
4213:
4208:
4206:
4201:
4200:
4197:
4181:
4178:
4177:
4175:
4172:
4168:
4158:
4155:
4153:
4150:
4149:
4147:
4145:
4141:
4135:
4132:
4130:
4127:
4126:
4124:
4122:
4118:
4111:
4107:
4103:
4101:
4098:
4096:
4093:
4091:
4088:
4087:
4085:
4083:
4079:
4076:
4074:and medullary
4068:
4057:
4053:
4049:
4045:
4041:
4040:
4038:
4036:
4032:
4026:
4023:
4019:
4016:
4015:
4013:
4009:
4005:
4001:
3998:
3997:
3996:
3993:
3992:
3990:
3988:
3984:
3978:
3974:
3971:
3970:
3968:
3965:
3961:
3958:
3950:
3944:
3941:
3937:
3934:
3932:
3929:
3928:
3927:
3924:
3923:
3921:
3915:
3905:
3902:
3900:
3897:
3895:
3892:
3890:
3887:
3885:
3882:
3880:
3877:
3873:
3870:
3869:
3868:
3865:
3864:
3862:
3858:
3852:
3849:
3847:
3843:
3840:
3838:
3835:
3833:
3830:
3829:
3827:
3825:
3821:
3815:
3812:
3810:
3807:
3805:
3802:
3801:
3799:
3797:
3793:
3787:
3783:
3780:
3778:
3775:
3773:
3770:
3769:
3764:
3761:
3759:
3756:
3754:
3751:
3749:
3746:
3744:
3741:
3740:
3739:
3736:
3735:
3732:
3729:
3727:
3724:
3721:
3720:
3718:
3716:
3712:
3709:
3707:
3702:
3698:
3695:
3693:
3689:
3679:
3676:
3674:
3671:
3669:
3666:
3665:
3663:
3661:
3657:
3651:
3648:
3646:
3643:
3641:
3638:
3636:
3633:
3631:
3628:
3626:
3623:
3621:
3618:
3617:
3615:
3613:
3609:
3605:
3602:
3600:
3596:
3592:
3584:
3579:
3577:
3572:
3570:
3565:
3564:
3561:
3548:
3544:
3543:
3539:
3537:
3533:
3532:
3528:
3527:
3524:
3520:
3513:
3509:
3508:
3504:
3502:
3498:
3497:
3493:
3491:
3487:
3486:
3482:
3481:
3478:
3473:
3469:
3458:
3454:
3453:Ekstra Bladet
3450:
3444:
3441:
3429:
3425:
3419:
3416:
3411:
3407:
3402:
3397:
3393:
3389:
3385:
3381:
3377:
3370:
3367:
3362:
3358:
3351:
3348:
3343:
3339:
3335:
3331:
3327:
3323:
3316:
3313:
3308:
3304:
3299:
3294:
3290:
3286:
3282:
3275:
3272:
3267:
3261:
3257:
3251:
3248:
3241:
3237:
3232:
3227:
3223:
3219:
3215:
3211:
3207:
3202:
3201:
3199:
3193:
3190:
3185:
3181:
3175:
3172:
3167:
3163:
3157:
3154:
3149:
3145:
3138:
3135:
3130:
3126:
3119:
3116:
3111:
3107:
3101:
3098:
3093:
3089:
3083:
3081:
3077:
3072:
3068:
3062:
3060:
3058:
3054:
3043:
3039:
3032:
3029:
3018:
3014:
3008:
3005:
2993:
2989:
2983:
2980:
2975:
2971:
2966:
2961:
2956:
2951:
2947:
2943:
2939:
2932:
2929:
2924:
2920:
2915:
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2906:
2902:
2898:
2894:
2890:
2883:
2880:
2875:
2871:
2866:
2861:
2856:
2851:
2847:
2843:
2839:
2832:
2829:
2824:
2823:Bionical Emas
2821:
2815:
2812:
2807:
2803:
2799:
2795:
2791:
2787:
2779:
2776:
2771:
2767:
2762:
2757:
2753:
2749:
2745:
2741:
2737:
2730:
2727:
2722:
2718:
2713:
2708:
2704:
2700:
2696:
2689:
2687:
2683:
2678:
2674:
2670:
2666:
2662:
2658:
2654:
2650:
2643:
2640:
2635:
2631:
2625:
2622:
2617:
2613:
2607:
2604:
2599:
2593:
2590:
2585:
2581:
2577:
2571:
2568:
2555:
2549:
2546:
2542:
2541:public domain
2524:. 16 May 2024
2523:
2521:
2515:
2509:
2506:
2501:
2500:curetoday.com
2497:
2491:
2488:
2483:
2479:
2473:
2470:
2465:
2461:
2455:
2452:
2447:
2443:
2437:
2434:
2430:
2429:public domain
2411:
2409:
2403:
2397:
2394:
2390:
2389:public domain
2371:
2369:
2363:
2357:
2354:
2341:
2335:
2332:
2319:
2315:
2309:
2306:
2294:
2292:
2286:
2280:
2277:
2272:
2268:
2263:
2258:
2254:
2250:
2247:(42): e8176.
2246:
2242:
2238:
2231:
2228:
2223:
2219:
2215:
2211:
2207:
2203:
2199:
2195:
2188:
2181:
2178:
2173:
2169:
2164:
2159:
2155:
2151:
2147:
2143:
2136:
2134:
2130:
2125:
2121:
2116:
2111:
2107:
2103:
2099:
2092:
2089:
2084:
2080:
2076:
2072:
2065:
2062:
2057:
2053:
2048:
2043:
2039:
2035:
2031:
2027:
2023:
2016:
2013:
2002:on 2019-02-05
2001:
1997:
1993:
1989:
1985:
1981:
1974:
1971:
1959:
1955:
1951:
1947:
1941:
1939:
1935:
1924:
1920:
1916:
1910:
1907:
1902:
1898:
1894:
1890:
1886:
1882:
1875:
1872:
1866:
1860:
1852:
1848:
1840:
1837:
1832:
1828:
1824:
1818:
1815:
1810:
1806:
1800:
1797:
1784:
1780:
1776:
1770:
1767:
1762:
1758:
1754:
1750:
1746:
1742:
1738:
1734:
1730:
1726:
1719:
1717:
1713:
1708:
1704:
1700:
1696:
1692:
1688:
1684:
1680:
1673:
1670:
1665:
1661:
1656:
1651:
1647:
1643:
1640:(1): e13122.
1639:
1635:
1631:
1624:
1621:
1616:
1612:
1607:
1602:
1598:
1594:
1590:
1586:
1582:
1575:
1572:
1567:
1563:
1558:
1553:
1549:
1545:
1541:
1534:
1531:
1526:
1522:
1517:
1512:
1508:
1504:
1500:
1496:
1492:
1485:
1482:
1477:
1473:
1468:
1463:
1459:
1455:
1451:
1444:
1441:
1430:
1426:
1420:
1417:
1414:
1410:
1409:
1403:
1400:
1395:
1391:
1386:
1381:
1376:
1371:
1367:
1363:
1359:
1352:
1349:
1344:
1340:
1335:
1330:
1326:
1322:
1318:
1311:
1308:
1303:
1299:
1295:
1291:
1287:
1283:
1279:
1275:
1267:
1264:
1248:
1244:
1238:
1231:
1230:
1222:
1220:
1218:
1214:
1209:
1205:
1200:
1195:
1190:
1185:
1182:(1): 99–119.
1181:
1177:
1173:
1166:
1164:
1160:
1155:
1149:
1145:
1138:
1136:
1132:
1127:
1121:
1117:
1110:
1107:
1102:
1098:
1091:
1088:
1083:
1079:
1075:
1071:
1064:
1061:
1056:
1052:
1047:
1042:
1038:
1034:
1030:
1026:
1022:
1015:
1012:
1007:
1003:
997:
994:
989:
985:
979:
976:
971:
967:
961:
958:
948:
944:
940:
936:
929:
927:
923:
918:
914:
909:
904:
900:
896:
892:
888:
884:
877:
874:
869:
865:
860:
855:
851:
847:
843:
839:
835:
828:
825:
822:
821:
816:
811:
808:
801:
792:
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3832:Prolactinoma
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1960:. 1980-01-01
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720:Epidemiology
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707:
703:radiotherapy
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696:
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679:As of 2015,
678:
669:chemotherapy
654:
644:
634:
630:temozolomide
623:
619:bendamustine
615:temozolomide
612:
609:Novel agents
595:
592:(Camptosar)
560:
551:
543:
524:Atezolizumab
516:(Opdivo), a
504:
487:
456:chemotherapy
453:
450:Chemotherapy
444:chemotherapy
425:
422:
409:radiotherapy
399:In cases of
398:
385:
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330:
303:, including
294:
290:
266:
259:carcinomas.
257:
244:
220:
198:
190:
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113:
112:
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4839:Lung cancer
4526:Mediastinum
4455:By location
4258:Nasopharynx
3973:Cystadenoma
3926:sweat gland
3917:Adnexal and
3748:Glucagonoma
3531:MedlinePlus
2636:. May 2020.
838:Rare Tumors
730:lung cancer
661:trilaciclib
646:Trilaciclib
578:Vincristine
572:Doxorubicin
473:Carboplatin
440:carboplatin
436:vincristine
307:(ACTH) and
235:lung cancer
186:lymph nodes
85:Field stain
41:Other names
4818:Categories
3956:and serous
3899:Cylindroma
3884:Oncocytoma
3796:Urogenital
3753:Gastrinoma
3743:Insulinoma
3599:Epithelium
3434:2021-02-06
3361:Fred Hutch
3328:(1): 1–5.
3047:2021-02-16
3022:2020-12-28
2998:2020-12-04
2616:cancer.org
2464:cancer.org
2446:Cure Today
2006:2021-08-01
1964:2019-06-02
1928:2019-06-02
1434:2021-08-01
1368:(75): 75.
952:2023-10-02
939:StatPearls
802:References
603:paclitaxel
590:Irinotecan
584:Paclitaxel
534:Tarlatamab
490:paclitaxel
201:metastatic
174:metastases
61:Micrograph
4824:Carcinoma
4776:Carcinoma
4633:Germ cell
4601:Sex cord–
4592:Testicles
4513:Malignant
4423:carcinoma
4369:Carcinoid
3954:mucinous,
3936:Syringoma
3872:Carcinoid
3824:Endocrine
3612:carcinoma
3608:Papilloma
3542:eMedicine
3507:SNOMED CT
2806:190884224
2214:2123/4068
1413:eMedicine
1095:Selby K.
675:Prognosis
659:approved
599:topotecan
580:(Oncovin)
514:Nivolumab
488:The drug
477:etoposide
467:etoposide
463:Cisplatin
428:cisplatin
390:Treatment
354:Diagnosis
315:(SIADH).
194:cytoplasm
118:malignant
93:Specialty
73:cytoplasm
4723:Prostate
4705:Embryoma
4695:Teratoma
4650:Seminoma
4446:Melanoma
4436:Lymphoma
4295:Lower RT
4238:Upper RT
4072:lobular,
3987:Mucinous
3738:pancreas
3701:Adenomas
3547:med/1336
3410:30723171
3307:17008688
3240:18390646
3129:Medscape
2974:31504118
2923:30362375
2874:28961837
2770:31416802
2721:29894661
2677:54471245
2669:30528688
2318:DailyMed
2271:29049199
2241:Medicine
2222:17881133
2172:24282143
2163:11364206
2124:20101141
2056:26207205
1996:11098505
1984:Oncology
1952:. U.S.:
1923:UpToDate
1901:22116854
1859:cite web
1831:Archived
1809:Archived
1789:30 April
1783:Archived
1761:22482871
1753:18567862
1707:36759747
1699:24259701
1664:33296145
1615:23205072
1566:12463494
1476:18979286
1394:22078012
1343:15519208
1302:19159554
1294:21210145
1256:27 March
1247:Archived
1208:34164589
1082:11693903
1055:24163749
947:29494065
917:21475596
868:21464879
626:olaparib
380:neoplasm
327:Genetics
184:and the
133:prostate
98:Oncology
4431:Sarcoma
4304:Trachea
4070:Ductal,
3966:general
3952:Cystic,
3894:Apudoma
3673:Thymoma
3501:D018288
3490:M8041/3
3401:6530478
3342:7850764
3231:3044470
3168:. 2019.
2965:6857609
2914:6331752
2865:5834091
2761:7319046
2580:Reuters
2416:28 June
2376:16 June
2346:15 June
2298:15 June
2262:5662365
2047:4483471
1881:Science
1733:Bibcode
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1606:3506697
1525:9227387
1516:1296316
1429:Dynamed
1385:3253713
1199:8218894
1046:3804877
908:3072185
859:3070456
740:Society
642:(EAP).
586:(Taxol)
419:ES-SCLC
413:surgery
401:LS-SCLC
395:LS-SCLC
4578:Tumors
4500:Pleura
4275:Larynx
4226:Cancer
4171:Acinar
4035:Serous
3964:Cystic
3758:VIPoma
3723:tract:
3692:Glands
3591:cancer
3536:000122
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540:(2024)
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520:(2018)
178:thorax
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129:cervix
121:cancer
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4768:Penis
4741:HGPIN
3485:ICD-O
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2802:S2CID
2673:S2CID
2522:(FDA)
2518:U.S.
2410:(FDA)
2406:U.S.
2370:(FDA)
2366:U.S.
2293:(FDA)
2289:U.S.
2190:(PDF)
1757:S2CID
1703:S2CID
1298:S2CID
1250:(PDF)
1233:(PDF)
285:X-ray
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4322:Lung
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3338:PMID
3303:PMID
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3148:Self
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2919:PMID
2870:PMID
2766:PMID
2717:PMID
2665:PMID
2562:2024
2530:2024
2418:2020
2378:2020
2348:2020
2326:2020
2300:2020
2267:PMID
2218:PMID
2168:PMID
2120:PMID
2079:PMID
2052:PMID
1992:PMID
1897:PMID
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1729:1132
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1660:PMID
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1562:PMID
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1472:PMID
1390:PMID
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