1336:. Two different types of mutations exist within the group of missense mutations causing loss of NCC function. Type I mutations cause a complete loss of NCC function, in which the synthesized protein is not properly glycosylated. NCC protein harboring type I mutations is retained in the endoplasmic reticulum and cannot be trafficked to the cell surface. Type II mutations cause a partial loss of NCC function in which the cotransporter is trafficked to the cell surface but has an impaired insertion in the plasma membrane. NCC harboring type II mutations have normal kinetic properties but are present in lower amounts at the cell surface, resulting in a decreased uptake of sodium and chloride. NCC harboring type II mutations is still under control of its modulators and can still increase or decrease its activity in response to stimuli, whereas type I mutations cause a complete loss of function and regulation of the cotransporter. However, in some patients with Gitelman's syndrome, no mutations in the NCC gene have been found despite extensive genetic work-up.
260:
237:
134:
159:
266:
165:
42:
1348:
in the open population, with both common polymorphisms and rare mutations altering NCC function, renal salt reabsorption and, presumably, blood pressure. Individuals with rare mutations in genes responsible for salt control in the kidney, including NCC, have been found to have a lower blood pressure
1253:
across the apical membrane of the cells in distal convoluted tubule, the sodium-chloride symporter transports Na and Cl from the tubular fluid into these cells. Afterward, the Na is pumped out of the cell and into the bloodstream by the Na-K ATPase located at the
2023:
Acuña R, Martínez-de-la-Maza L, Ponce-Coria J, Vázquez N, Ortal-Vite P, Pacheco-Alvarez D, et al. (March 2011). "Rare mutations in SLC12A1 and SLC12A3 protect against hypertension by reducing the activity of renal salt cotransporters".
1573:
Mastroianni N, De Fusco M, Zollo M, Arrigo G, Zuffardi O, Bettinelli A, et al. (August 1996). "Molecular cloning, expression pattern, and chromosomal localization of the human Na-Cl thiazide-sensitive cotransporter (SLC12A3)".
1142:, an autosomic recessive disease characterized by salt wasting and low blood pressure, hypokalemic metabolic alkalosis, hypomagnesemia and hypocalciuria. Over a hundred different mutations in the NCC gene have been identified.
2116:
Fava C, Montagnana M, Rosberg L, Burri P, Almgren P, Jönsson A, et al. (February 2008). "Subjects heterozygous for genetic loss of function of the thiazide-sensitive cotransporter have reduced blood pressure".
2798:
Wang XF, Lin RY, Wang SZ, Zhang LP, Qian J, Lu DR, et al. (February 2008). "Association study of variants in two ion-channel genes (TSC and CLCNKB) and hypertension in two ethnic groups in
Northwest China".
2679:
Qin L, Shao L, Ren H, Wang W, Pan X, Zhang W, et al. (February 2009). "Identification of five novel variants in the thiazide-sensitive NaCl co-transporter gene in
Chinese patients with Gitelman syndrome".
2250:
Coto E, Arriba G, García-Castro M, Santos F, Corao AI, Díaz M, et al. (2009). "Clinical and analytical findings in
Gitelman's syndrome associated with homozygosity for the c.1925 G>A SLC12A3 mutation".
2760:
Richardson C, Rafiqi FH, Karlsson HK, Moleleki N, Vandewalle A, Campbell DG, et al. (March 2008). "Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1".
1984:
Sabath E, Meade P, Berkman J, de los Heros P, Moreno E, Bobadilla NA, et al. (August 2004). "Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in
Gitelman disease".
2309:
Shao L, Liu L, Miao Z, Ren H, Wang W, Lang Y, et al. (2008). "A novel SLC12A3 splicing mutation skipping of two exons and preliminary screening for alternative splice variants in human kidney".
2719:"Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study"
1357:
cotransporter although some mutations found in individuals in the open population seem to be less deleterious to cotransporter function than mutations in individuals with
Gitelman's syndrome.
2213:
Kamdem LK, Hamilton L, Cheng C, Liu W, Yang W, Johnson JA, et al. (June 2008). "Genetic predictors of glucocorticoid-induced hypertension in children with acute lymphoblastic leukemia".
1379:(PHA2), also known as Gordon's syndrome or Familial Hyperkalemic Hypertension (FHHt), is an autosomal dominant disease in which there is an increase in NCC activity leading to short stature,
1284:
Furthermore, many residues of NCC can be phosphorylated or dephosphorylated to activate or inhibit NCC uptake of Na and Cl. Other NCC modulators, including intracellular chloride depletion,
1273:
As NCC has to be at the plasma membrane to function, its activity can be regulated by increasing or decreasing the amount of protein at the plasma membrane. Some NCC modulators, such as the
273:
172:
3589:
6610:
4969:
1150:
The sodium-chloride symporter or NCC is a member of the SLC12 cotransporter family of electroneutral cation-coupled chloride cotransporter, along with the
1317:, an autosomic recessive disease characterized by salt wasting and low blood pressure, hypokalemic metabolic alkalosis, hypomagnesemia and hypocalciuria.
1281:
kinases may regulate the amount of NCC at the cell surface by inducing the insertion or removal, respectively, of the protein from the plasma membrane.
780:
2830:"Coexistence of normotensive primary aldosteronism in two patients with Gitelman's syndrome and novel thiazide-sensitive Na-Cl cotransporter mutations"
761:
95:
6010:
4875:
6679:
6405:
5931:
1552:
3354:
1534:
6263:
4131:
3800:
3567:
2381:
Shao L, Ren H, Wang W, Zhang W, Feng X, Li X, et al. (2008). "Novel SLC12A3 mutations in
Chinese patients with Gitelman's syndrome".
2611:"Genetic variation at the SLC12A3 locus is unlikely to explain risk for advanced diabetic nephropathy in Caucasians with type 2 diabetes"
5273:
4767:
3693:
3688:
3613:
3582:
2968:
1266:. NCC activity is known to have two control mechanisms affecting protein trafficking to the plasma membrane and transporter kinetics by
3350:
259:
1714:"WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis"
1004:
1945:"Functional expression of mutations in the human NaCl cotransporter: evidence for impaired routing mechanisms in Gitelman's syndrome"
6659:
6560:
5727:
4689:
3987:
3901:
3658:
1011:
236:
4491:
2943:
2541:"Heterozygous mutations of the sodium chloride cotransporter in Chinese children: prevalence and association with blood pressure"
4752:
3828:
3673:
1521:
1500:
6600:
4227:
1822:"The Na+:Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion"
6684:
6580:
6575:
6546:
5087:
4651:
4453:
4448:
3575:
2921:
1904:"Vasopressin induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter in the distal convoluted tubule"
1226:
1155:
158:
133:
1517:
1863:"Angiotensin II induces phosphorylation of the thiazide-sensitive sodium chloride cotransporter independent of aldosterone"
4646:
4641:
4636:
4621:
4616:
4611:
4606:
4396:
5972:
5774:
5574:
2346:
van Rijn-Bikker PC, Mairuhu G, van
Montfrans GA, Sijbrands EJ, Zwinderman AH, Guchelaar HJ, et al. (December 2009).
1496:
6570:
2348:"Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population"
1225:
occurs in two sites in a long extracellular loop connecting two transmembrane domains within the hydrophobic core. This
1151:
75:
4562:
272:
171:
5542:
5421:
1296:, can regulate NCC activity by phosphorylating conserved serine/threonine residues. NCC activity can be inhibited by
5125:
265:
164:
5494:
3997:
3606:
2952:
6151:
5807:
4300:
3557:
3317:
3312:
6339:
2911:
1665:"The thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKs"
6605:
4427:
4194:
2915:
2905:
1437:
1320:
Over a hundred different mutations in the NCC gene have been described as causing
Gitelman syndrome, including
1111:
825:
83:
6296:
4823:
6565:
6197:
3926:
1376:
1212:
806:
2875:
Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue
Yichuanxue Zazhi = Chinese Journal of Medical Genetics
3410:
1222:
6541:
6377:
6063:
5248:
5173:
4567:
4438:
4433:
4007:
3609:
1192:
1132:
1119:
147:
2901:
2461:
Riveira-Munoz E, Devuyst O, Belge H, Jeck N, Strompf L, Vargas-Poussou R, et al. (October 2008).
1820:
Pacheco-Alvarez D, Cristóbal PS, Meade P, Moreno E, Vazquez N, Muñoz E, et al. (September 2006).
6638:
6633:
4600:
4002:
2936:
2165:
1725:
1413:
1329:
62:
3445:
17:
6230:
3936:
3711:
1861:
van der Lubbe N, Lim CH, Fenton RA, Meima ME, Jan Danser AH, Zietse R, et al. (January 2011).
1325:
1263:
1255:
1242:
1200:
983:
962:
958:
924:
903:
899:
1712:
Rinehart J, Kahle KT, de Los Heros P, Vazquez N, Meade P, Wilson FH, et al. (November 2005).
3992:
2786:
2705:
2406:
2334:
2276:
2238:
2049:
1350:
107:
2420:"Rare independent mutations in renal salt handling genes contribute to blood pressure variation"
2152:
Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, et al. (January 2012).
2069:"Rare independent mutations in renal salt handling genes contribute to blood pressure variation"
1943:
De Jong JC, Van Der Vliet WA, Van Den Heuvel LP, Willems PH, Knoers NV, Bindels RJ (June 2002).
1176:
1124:
987:
954:
928:
895:
1368:
and do not have the disease) have a lower blood pressure than non-carriers in the same family.
1364:
of mutations causing
Gitelman syndrome (i.e. individuals who have a mutation in one of the two
6133:
6128:
5476:
5471:
5398:
5393:
5388:
5383:
5378:
5373:
5353:
5348:
5343:
5338:
5323:
5313:
5303:
5298:
5288:
5263:
5069:
5054:
5049:
4671:
4666:
4661:
2882:
2861:
2816:
2778:
2748:
2697:
2667:
2632:
2597:
2562:
2527:
2484:
2449:
2398:
2369:
2326:
2297:
2268:
2230:
2191:
2134:
2098:
2041:
2002:
1966:
1925:
1884:
1843:
1802:
1753:
1694:
1645:
1591:
1333:
1321:
1314:
1262:. The sodium-chloride symporter accounts for the absorption of 5% of the salt filtered at the
1139:
55:
6387:
6354:
6321:
6311:
6278:
6273:
6207:
6088:
6040:
6030:
5987:
5951:
5946:
5913:
5908:
5903:
5898:
5889:
5884:
5879:
5851:
5841:
5832:
5827:
5822:
5657:
5642:
5637:
5622:
5589:
5556:
5466:
5426:
5183:
5155:
5140:
5135:
5130:
5107:
5102:
4950:
4946:
4937:
4895:
4719:
4709:
4699:
4631:
4577:
4511:
4496:
4330:
4325:
4320:
4171:
4072:
4067:
4037:
3961:
3956:
3951:
3878:
3544:
3539:
3524:
3212:
103:
6433:
4534:
4272:
4262:
4247:
4209:
4204:
4022:
3946:
3873:
3598:
3508:
3502:
3497:
3475:
3465:
3455:
3422:
3304:
3299:
3289:
3070:
3010:
2851:
2841:
2808:
2770:
2738:
2730:
2689:
2657:
2622:
2587:
2552:
2517:
2509:
2474:
2439:
2431:
2390:
2359:
2318:
2260:
2222:
2181:
2173:
2126:
2088:
2080:
2033:
1994:
1956:
1915:
1874:
1833:
1792:
1784:
1743:
1733:
1684:
1676:
1635:
1625:
1583:
1167:
352:
283:
227:
182:
3486:
3326:
3321:
1300:, which is why this symporter is also known as the thiazide-sensitive Na-Cl cotransporter.
6517:
3602:
3434:
3260:
2956:
2929:
2646:"Case-control study of the role of the Gitelman's syndrome gene in essential hypertension"
1361:
1267:
1250:
1246:
1230:
1122:
of electroneutral cation-coupled chloride cotransporters. In humans, it is encoded by the
327:
2154:"Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities"
2463:"Evaluating PVALB as a candidate gene for SLC12A3-negative cases of Gitelman's syndrome"
2169:
1729:
3358:
3342:
2743:
2718:
2522:
2497:
2444:
2419:
2186:
2153:
2093:
2068:
1961:
1944:
1797:
1772:
1748:
1713:
1689:
1664:
1640:
1613:
1464:
1388:
1345:
1285:
1196:
695:
690:
685:
680:
675:
670:
665:
660:
655:
650:
645:
640:
624:
619:
614:
609:
604:
599:
594:
578:
573:
568:
563:
558:
553:
548:
543:
6673:
6533:
3438:
3250:
2693:
2053:
1455:
1216:
1107:
1088:
530:
2790:
2734:
2709:
2498:"WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway"
2496:
Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino WB, et al. (January 2010).
2410:
2338:
2280:
1773:"WNK4 enhances the degradation of NCC through a sortilin-mediated lysosomal pathway"
1771:
Zhou B, Zhuang J, Gu D, Wang H, Cebotaru L, Guggino WB, et al. (January 2010).
2977:
2964:
2873:
Zhan YY, Jiang X, Lin G, Li J, Sheng HH, Xiao HS, et al. (December 2007). "".
2242:
1384:
1380:
1211:
domains. The exact structure of the NCC protein is unknown, as it has not yet been
345:
124:
87:
2592:
2575:
2574:
Nozu K, Iijima K, Nozu Y, Ikegami E, Imai T, Fu XJ, et al. (November 2009).
2226:
2037:
111:
6156:
5612:
5208:
4409:
1998:
1680:
1557:
National Center for Biotechnology Information, U.S. National Library of Medicine
1539:
National Center for Biotechnology Information, U.S. National Library of Medicine
1442:
1293:
1289:
2717:
Ridker PM, Paré G, Parker AN, Zee RY, Miletich JP, Chasman DI (February 2009).
2644:
Aoi N, Nakayama T, Sato N, Kosuge K, Haketa A, Sato M, et al. (May 2008).
1718:
Proceedings of the National Academy of Sciences of the United States of America
428:
6592:
5750:
2812:
2418:
Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, et al. (May 2008).
2067:
Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, et al. (May 2008).
1208:
1204:
1188:
244:
141:
91:
66:, NCC, NCCT, TSC, solute carrier family 12 member 3, Sodium-chloride symporter
2662:
2645:
6529:
2828:
Miao Z, Gao Y, Bindels RJ, Yu W, Lang Y, Chen N, et al. (August 2009).
1902:
Pedersen NB, Hofmeister MV, Rosenbaek LL, Nielsen J, Fenton RA (July 2010).
1738:
1473:
1469:
1459:
1354:
725:
488:
366:
311:
298:
210:
197:
99:
2886:
2865:
2820:
2782:
2752:
2701:
2671:
2636:
2601:
2566:
2531:
2513:
2488:
2453:
2402:
2373:
2330:
2301:
2272:
2234:
2195:
2138:
2102:
2045:
2006:
1970:
1929:
1888:
1847:
1838:
1821:
1806:
1788:
1757:
1698:
1649:
1630:
1587:
1595:
1051:
1046:
6123:
6118:
6113:
6045:
5662:
5403:
5368:
5363:
5358:
5333:
5328:
5318:
5308:
5293:
5283:
5278:
5268:
5258:
5253:
5243:
5233:
5228:
5223:
5064:
5059:
5044:
5039:
5034:
5029:
5024:
5019:
4789:
4656:
3983:
3418:
3217:
3207:
3202:
3187:
3182:
3177:
3167:
3162:
3157:
3147:
3142:
3132:
3127:
3122:
3117:
3098:
3090:
2986:
2627:
2610:
2576:"A deep intronic mutation in the SLC12A3 gene leads to Gitelman syndrome"
2557:
2540:
2479:
2462:
2364:
2347:
2130:
1450:
1392:
1297:
1100:
1035:
870:
851:
2846:
2829:
2177:
1920:
1903:
1879:
1862:
41:
6490:
6485:
6480:
6475:
6470:
6465:
6415:
6410:
6382:
6359:
6349:
6344:
6316:
6306:
6301:
6268:
6212:
6202:
6108:
6103:
6098:
6093:
6083:
6078:
6073:
6068:
6035:
6025:
6020:
6015:
5992:
5982:
5977:
5954:
5941:
5936:
5870:
5865:
5856:
5846:
5817:
5812:
5789:
5784:
5779:
5756:
5732:
5709:
5652:
5647:
5632:
5627:
5617:
5594:
5584:
5579:
5551:
5546:
5524:
5519:
5514:
5509:
5504:
5499:
5461:
5456:
5451:
5446:
5441:
5436:
5431:
5218:
5213:
5203:
5198:
5193:
5188:
5178:
5150:
5145:
5097:
5092:
5014:
5009:
5004:
4999:
4994:
4989:
4984:
4979:
4974:
4932:
4923:
4914:
4909:
4900:
4890:
4885:
4880:
4834:
4829:
4805:
4800:
4795:
4734:
4729:
4724:
4714:
4704:
4694:
4626:
4582:
4572:
4544:
4539:
4516:
4506:
4501:
4473:
4468:
4463:
4458:
4406:
4401:
4357:
4352:
4347:
4342:
4335:
4315:
4310:
4305:
4282:
4277:
4176:
4166:
4161:
4087:
4082:
4077:
4062:
4057:
4052:
4047:
4042:
3883:
3781:
3776:
3771:
3766:
3761:
3534:
3529:
3197:
3192:
3172:
3152:
3137:
3112:
3107:
3102:
2774:
1432:
1184:
1163:
1159:
1115:
837:
792:
2856:
2394:
2322:
2264:
1391:
and hyperchloremic metabolic acidosis. However, PHA2 is not caused by
6614:
5703:
5238:
4785:
4267:
4257:
4252:
4242:
4237:
4232:
4199:
4156:
4151:
4146:
4141:
4123:
4118:
4113:
4108:
4032:
4027:
4017:
4012:
3979:
3941:
3931:
3921:
3916:
3906:
3868:
3863:
3858:
3853:
3848:
3843:
3838:
3833:
3810:
3805:
3756:
3746:
3741:
3683:
3678:
3668:
3663:
3518:
3513:
3492:
3470:
3460:
3397:
3392:
3387:
3382:
3377:
3372:
3367:
3362:
3334:
3294:
3284:
3279:
3274:
3269:
3264:
3234:
3224:
3060:
3040:
3035:
3030:
3025:
3005:
2995:
2960:
1446:
1365:
1259:
1171:
1096:
1092:
1019:
747:
2609:
Ng DP, Nurbaya S, Choo S, Koh D, Chia KS, Krolewski AS (July 2008).
1229:
is necessary for proper folding and transport of the protein to the
2435:
2084:
1423:. Patients respond well to treatment with thiazide-type diuretics.
4762:
4757:
3911:
3751:
3736:
3731:
3726:
3721:
3716:
3481:
3405:
3346:
3080:
3075:
3065:
3055:
3050:
3045:
3020:
3015:
3000:
2539:
Hsu YJ, Yang SS, Chu NF, Sytwu HK, Cheng CJ, Lin SH (April 2009).
2801:
Clinica Chimica Acta; International Journal of Clinical Chemistry
710:
706:
6245:
6240:
6235:
4136:
3449:
1419:
1407:
1401:
1399:(corresponding to NCC) gene, but by mutations in NCC regulators
1278:
1274:
1180:
1128:
1103:
79:
6515:
6454:
6179:
6011:
System A & N, sodium-coupled neutral amino-acid transporter
5685:
4857:
4378:
3640:
3625:
3571:
2925:
1245:
of the distal convoluted tubule of the nephron, it faces the
3659:
high affinity glutamate and neutral amino-acid transporter
1353:. NCC harboring these mutations has a lower function than
1344:
NCC has also been implicated to play a role in control of
1158:(Na-K-Cl cotransporters or NKCCs) and orphan member CIP (
4105:
cationic amino-acid transporter/glycoprotein-associated
2290:
Rinsho Byori. The Japanese Journal of Clinical Pathology
335:
4130:
glycoprotein-associated/light or catalytic subunits of
500:
6264:
Na-independent, system-L like amino-acid transporter
1258:
and the Cl leaves the cells through the basolateral
1249:
and is in contact with the tubular fluid. Using the
6591:
6528:
6426:
6398:
6370:
6332:
6289:
6256:
6223:
6190:
6144:
6056:
6003:
5965:
5924:
5800:
5767:
5743:
5720:
5696:
5605:
5567:
5535:
5487:
5414:
5166:
5118:
5080:
4962:
4868:
4816:
4778:
4745:
4682:
4593:
4555:
4527:
4484:
4420:
4389:
4293:
4220:
4187:
4098:
3972:
3894:
3821:
3792:
3704:
3651:
3249:
3233:
3089:
2985:
2976:
976:
947:
917:
888:
1513:
1511:
1509:
1492:
1490:
1488:
282:
181:
1987:American Journal of Physiology. Renal Physiology
1669:American Journal of Physiology. Renal Physiology
1170:has a high degree of identity between different
2018:
2016:
1131:(solute carrier family 12 member 3) located in
29:Protein-coding gene in the species Homo sapiens
1607:
1605:
1518:GRCm38: Ensembl release 89: ENSMUSG00000031766
3583:
2937:
2502:Journal of the American Society of Nephrology
1949:Journal of the American Society of Nephrology
1777:Journal of the American Society of Nephrology
1568:
1566:
1174:(over 90% between human, rat and mouse). The
574:sodium ion transmembrane transporter activity
8:
569:sodium:potassium:chloride symporter activity
4970:organic cation/anion/zwitterion transporter
1497:GRCh38: Ensembl release 89: ENSG00000070915
696:potassium ion import across plasma membrane
6525:
6512:
6451:
6187:
6176:
5693:
5682:
4865:
4854:
4492:human Na-sulfate/carboxylate cotransporter
4386:
4375:
3648:
3637:
3633:
3622:
3590:
3576:
3568:
2982:
2944:
2930:
2922:
1313:A loss of NCC function is associated with
721:
526:
323:
222:
119:
3333:3.A.3.1.4: H/K transporting, nongastric:
2914:at the U.S. National Library of Medicine
2904:at the U.S. National Library of Medicine
2855:
2845:
2742:
2661:
2626:
2591:
2556:
2521:
2478:
2443:
2363:
2185:
2092:
1960:
1919:
1878:
1837:
1796:
1747:
1737:
1688:
1639:
1629:
2288:Yasujima M, Tsutaya S (April 2009). "".
1270:of conserved serine/threonine residues.
1156:sodium-potassium-chloride cotransporters
5088:Na+-dependent ascorbic acid transporter
1484:
4876:Organic anion-transporting polypeptide
1612:Knoers NV, Levtchenko EN (July 2008).
1268:phosphorylation and de-phosphorylation
1095:which has the function of reabsorbing
1081:thiazide-sensitive Na-Cl cotransporter
31:
5932:proton-coupled amino-acid transporter
4132:heterodimeric amino-acid transporters
3801:heterodimeric amino-acid transporters
2615:Nephrology, Dialysis, Transplantation
2545:Nephrology, Dialysis, Transplantation
2467:Nephrology, Dialysis, Transplantation
610:integral component of plasma membrane
579:potassium:chloride symporter activity
287:
248:
243:
186:
145:
140:
7:
4397:proton coupled metal ion transporter
2912:Sodium+Chloride+Symporter+Inhibitors
2723:Circulation. Cardiovascular Genetics
18:Sodium chloride symporter inhibitors
5973:sugar-phosphate/phosphate exchanger
5575:facilitative nucleoside transporter
1826:The Journal of Biological Chemistry
1389:increased urinary calcium excretion
1154:(K-Cl cotransporters or KCCs), the
5775:type II Na-phosphate cotransporter
3988:sodium:neurotransmitter symporters
1962:10.1097/01.ASN.0000017904.77985.03
1166:. The sodium-chloride symporter's
973:
944:
914:
885:
861:
842:
816:
797:
771:
752:
651:sodium ion transmembrane transport
564:sodium:chloride symporter activity
544:cation:chloride symporter activity
505:
423:
361:
340:
25:
5728:Vesicular glutamate transporter 1
4690:Vesicular glutamate transporter 1
4563:proton oligopeptide cotransporter
2978:F-, V-, and A-type ATPase (3.A.2)
2834:European Journal of Endocrinology
1618:Orphanet Journal of Rare Diseases
1160:cotransporter interacting protein
1152:potassium-chloride cotransporters
2694:10.1111/j.1440-1797.2008.01042.x
2352:American Journal of Hypertension
641:chloride transmembrane transport
271:
264:
258:
235:
170:
163:
157:
132:
40:
5543:Na-coupled nucleoside transport
5422:multifunctional anion exchanger
4753:vesicular monoamine transporter
2994:H transporting, mitochondrial:
2735:10.1161/CIRCGENETICS.108.817304
1377:Type II pseudohypoaldosteronism
1372:Pseudohypoaldosteronism type II
1340:Hypertension and blood pressure
2311:American Journal of Nephrology
2253:American Journal of Nephrology
1241:Because NCC is located at the
1227:posttranslational modification
1138:A loss of NCC function causes
595:integral component of membrane
489:More reference expression data
1:
6406:multidrug and toxin extrusion
5495:fatty acid transport proteins
3712:facilitative GLUT transporter
2215:Pharmacogenetics and Genomics
256:
155:
6680:Genes on human chromosome 16
6152:basolateral iron transporter
5808:nucleoside-sugar transporter
4301:sodium bile salt cotransport
3902:sodium glucose cotransporter
2593:10.1203/PDR.0b013e3181b9b4d3
2227:10.1097/FPC.0b013e3282fc5801
2038:10.1097/HJH.0b013e328341d0fd
3607:membrane transport proteins
1999:10.1152/ajprenal.00044.2004
1681:10.1152/ajprenal.00159.2009
6701:
6340:Putative sugar transporter
3404:3.A.3.5: Cu transporting:
2953:Membrane transport protein
2902:Sodium+Chloride+Symporters
1360:Furthermore, heterozygous
1120:SLC12 cotransporter family
6655:
6524:
6511:
6461:
6450:
6186:
6175:
5692:
5681:
4864:
4853:
4385:
4374:
3647:
3636:
3632:
3621:
3553:
3099:H transporting, lysosomal
2813:10.1016/j.cca.2007.10.017
1553:"Mouse PubMed Reference:"
1535:"Human PubMed Reference:"
1065:sodium-chloride symporter
1050:
1045:
1041:
1034:
1018:
999:
980:
951:
940:
921:
892:
881:
868:
864:
849:
845:
836:
823:
819:
804:
800:
791:
778:
774:
759:
755:
746:
731:
724:
720:
704:
686:potassium ion homeostasis
529:
525:
513:
508:
499:
486:
435:
426:
373:
364:
334:
326:
322:
305:
292:
255:
234:
225:
221:
204:
191:
154:
131:
122:
118:
73:
70:
60:
53:
48:
39:
34:
6660:solute carrier disorders
6297:Choline-like transporter
4428:electroneutral cation-Cl
2916:Medical Subject Headings
2906:Medical Subject Headings
2663:10.1507/endocrj.K07E-021
2119:Human Molecular Genetics
1663:Gamba G (October 2009).
1438:Distal convoluted tubule
1385:increased serum K levels
1381:increased blood pressure
1219:at the plasma membrane.
1215:. The NCC protein forms
1118:. It is a member of the
1112:distal convoluted tubule
1005:Chr 16: 56.87 – 56.92 Mb
681:chloride ion homeostasis
6198:Magnesium transporter E
3829:bicarbonate transporter
2763:Journal of Cell Science
2026:Journal of Hypertension
1739:10.1073/pnas.0508303102
1260:chloride channel ClC-Kb
1012:Chr 8: 95.06 – 95.09 Mb
676:cell volume homeostasis
661:transmembrane transport
6593:Antiporter (exchanger)
2514:10.1681/ASN.2008121275
1839:10.1074/jbc.M603773200
1789:10.1681/ASN.2008121275
1631:10.1186/1750-1172-3-22
1588:10.1006/geno.1996.0388
1110:into the cells of the
691:sodium ion homeostasis
620:apical plasma membrane
397:pancreatic ductal cell
6685:Solute carrier family
6064:metal ion transporter
5174:mitochondrial carrier
4824:type III Na-phosphate
1201:transmembrane domains
1195:, presumed to have a
1193:transmembrane protein
615:extracellular exosome
455:primary visual cortex
148:Chromosome 16 (human)
2365:10.1038/ajh.2009.192
1908:Kidney International
1867:Kidney International
656:sodium ion transport
559:transporter activity
289:8 C5|8 46.46 cM
250:Chromosome 8 (mouse)
6231:Ammonia transporter
5126:Na/(Ca-K) exchanger
3507:Class VI, type 11:
2847:10.1530/EJE-09-0271
2383:Nephron. Physiology
2178:10.1038/nature10814
2170:2012Natur.482...98B
1921:10.1038/ki.2010.130
1880:10.1038/ki.2010.290
1832:(39): 28755–28763.
1730:2005PNAS..10216777R
1724:(46): 16777–16782.
1614:"Gitelman syndrome"
1247:lumen of the tubule
1203:with intracellular
1199:of either 10 or 12
1191:residues. NCC is a
1069:Na-Cl cotransporter
112:SLC12A3 - orthologs
6378:Folate transporter
3799:heavy subunits of
3491:Class V, type 10:
3480:Class II, type 9:
2775:10.1242/jcs.025312
2628:10.1093/ndt/gfm946
2580:Pediatric Research
2558:10.1093/ndt/gfn619
2480:10.1093/ndt/gfn229
2131:10.1093/hmg/ddm318
1334:missense mutations
1187:of 1,002 to 1,030
826:ENSMUSG00000031766
666:chloride transport
634:Biological process
588:Cellular component
554:symporter activity
537:Molecular function
385:buccal mucosa cell
6667:
6666:
6651:
6650:
6647:
6646:
6507:
6506:
6503:
6502:
6499:
6498:
6446:
6445:
6442:
6441:
6171:
6170:
6167:
6166:
5677:
5676:
5673:
5672:
4849:
4848:
4845:
4844:
4370:
4369:
4366:
4365:
3599:Membrane proteins
3565:
3564:
3454:Class I, type 8:
3261:Na/K transporting
3245:
3244:
2769:(Pt 5): 675–684.
2650:Endocrine Journal
2473:(10): 3120–3125.
2395:10.1159/000117815
2358:(12): 1295–1302.
2323:10.1159/000141932
2265:10.1159/000218104
1315:Gitelman syndrome
1309:Gitelman syndrome
1209:carboxyl-terminus
1172:mammalian species
1146:Molecular biology
1140:Gitelman syndrome
1061:
1060:
1057:
1056:
1030:
1029:
995:
994:
970:
969:
936:
935:
911:
910:
877:
876:
858:
857:
832:
831:
813:
812:
787:
786:
768:
767:
716:
715:
521:
520:
517:
516:
495:
494:
482:
481:
420:
419:
318:
317:
217:
216:
16:(Redirected from
6692:
6626:
6625:
6624:
6526:
6513:
6452:
6434:Heme transporter
6188:
6177:
5694:
5683:
4866:
4855:
4535:urea transporter
4387:
4376:
3649:
3638:
3634:
3623:
3603:carrier proteins
3592:
3585:
3578:
3569:
3558:ATPase disorders
3429:Other/ungrouped:
2983:
2946:
2939:
2932:
2923:
2890:
2869:
2859:
2849:
2824:
2794:
2756:
2746:
2713:
2675:
2665:
2640:
2630:
2621:(7): 2260–2264.
2605:
2595:
2570:
2560:
2551:(4): 1170–1175.
2535:
2525:
2492:
2482:
2457:
2447:
2414:
2377:
2367:
2342:
2305:
2284:
2246:
2200:
2199:
2189:
2164:(7383): 98–102.
2149:
2143:
2142:
2113:
2107:
2106:
2096:
2064:
2058:
2057:
2020:
2011:
2010:
1993:(2): F195–F203.
1981:
1975:
1974:
1964:
1955:(6): 1442–1448.
1940:
1934:
1933:
1923:
1899:
1893:
1892:
1882:
1858:
1852:
1851:
1841:
1817:
1811:
1810:
1800:
1768:
1762:
1761:
1751:
1741:
1709:
1703:
1702:
1692:
1675:(4): F838–F848.
1660:
1654:
1653:
1643:
1633:
1609:
1600:
1599:
1570:
1561:
1560:
1549:
1543:
1542:
1531:
1525:
1515:
1504:
1494:
1197:hydrophobic core
1168:protein sequence
1043:
1042:
1014:
1007:
990:
974:
965:
945:
941:RefSeq (protein)
931:
915:
906:
886:
862:
843:
817:
798:
772:
753:
722:
527:
506:
491:
431:
429:Top expressed in
424:
409:mononuclear cell
369:
367:Top expressed in
362:
341:
324:
314:
301:
290:
275:
268:
262:
251:
239:
223:
213:
200:
189:
174:
167:
161:
150:
136:
120:
114:
65:
58:
44:
32:
21:
6700:
6699:
6695:
6694:
6693:
6691:
6690:
6689:
6670:
6669:
6668:
6663:
6643:
6623:
6620:
6619:
6618:
6616:
6587:
6550:
6520:
6495:
6457:
6438:
6422:
6394:
6366:
6328:
6285:
6252:
6219:
6182:
6163:
6140:
6052:
5999:
5961:
5920:
5796:
5763:
5739:
5716:
5688:
5669:
5601:
5563:
5531:
5483:
5410:
5162:
5114:
5076:
4958:
4860:
4841:
4812:
4774:
4741:
4678:
4601:monocarboxylate
4589:
4551:
4523:
4480:
4416:
4381:
4362:
4289:
4216:
4195:Na/Ca exchanger
4183:
4094:
3968:
3890:
3817:
3788:
3700:
3643:
3628:
3617:
3596:
3566:
3561:
3549:
3446:Mg transporting
3359:Ca transporting
3241:
3240:found in Archea
3229:
3085:
2972:
2950:
2898:
2893:
2872:
2827:
2797:
2759:
2716:
2678:
2643:
2608:
2573:
2538:
2495:
2460:
2424:Nature Genetics
2417:
2380:
2345:
2308:
2287:
2249:
2212:
2208:
2206:Further reading
2203:
2151:
2150:
2146:
2115:
2114:
2110:
2073:Nature Genetics
2066:
2065:
2061:
2022:
2021:
2014:
1983:
1982:
1978:
1942:
1941:
1937:
1901:
1900:
1896:
1860:
1859:
1855:
1819:
1818:
1814:
1770:
1769:
1765:
1711:
1710:
1706:
1662:
1661:
1657:
1611:
1610:
1603:
1572:
1571:
1564:
1551:
1550:
1546:
1533:
1532:
1528:
1516:
1507:
1495:
1486:
1482:
1429:
1374:
1342:
1311:
1306:
1251:sodium gradient
1243:apical membrane
1239:
1231:plasma membrane
1223:N-glycosylation
1148:
1067:(also known as
1052:View/Edit Mouse
1047:View/Edit Human
1010:
1003:
1000:Location (UCSC)
986:
982:
961:
957:
953:
927:
923:
902:
898:
894:
807:ENSG00000070915
700:
629:
605:plasma membrane
583:
549:protein binding
487:
478:
475:muscle of thigh
473:
469:
465:
463:proximal tubule
461:
457:
453:
449:
445:
441:
427:
416:
411:
407:
403:
399:
395:
391:
387:
383:
379:
365:
309:
296:
288:
278:
277:
276:
269:
249:
226:Gene location (
208:
195:
187:
177:
176:
175:
168:
146:
123:Gene location (
74:
61:
54:
30:
23:
22:
15:
12:
11:
5:
6698:
6696:
6688:
6687:
6682:
6672:
6671:
6665:
6664:
6656:
6653:
6652:
6649:
6648:
6645:
6644:
6642:
6641:
6636:
6631:
6630:
6629:
6621:
6603:
6597:
6595:
6589:
6588:
6586:
6585:
6584:
6583:
6578:
6568:
6563:
6558:
6553:
6548:
6544:
6538:
6536:
6522:
6521:
6516:
6509:
6508:
6505:
6504:
6501:
6500:
6497:
6496:
6494:
6493:
6488:
6483:
6478:
6473:
6468:
6462:
6459:
6458:
6455:
6448:
6447:
6444:
6443:
6440:
6439:
6437:
6436:
6430:
6428:
6424:
6423:
6421:
6420:
6419:
6418:
6413:
6402:
6400:
6396:
6395:
6393:
6392:
6391:
6390:
6385:
6374:
6372:
6368:
6367:
6365:
6364:
6363:
6362:
6357:
6352:
6347:
6336:
6334:
6330:
6329:
6327:
6326:
6325:
6324:
6319:
6314:
6309:
6304:
6293:
6291:
6287:
6286:
6284:
6283:
6282:
6281:
6276:
6271:
6260:
6258:
6254:
6253:
6251:
6250:
6249:
6248:
6243:
6238:
6227:
6225:
6221:
6220:
6218:
6217:
6216:
6215:
6210:
6205:
6194:
6192:
6184:
6183:
6180:
6173:
6172:
6169:
6168:
6165:
6164:
6162:
6161:
6160:
6159:
6148:
6146:
6142:
6141:
6139:
6138:
6137:
6136:
6131:
6126:
6121:
6116:
6111:
6106:
6101:
6096:
6091:
6086:
6081:
6076:
6071:
6060:
6058:
6054:
6053:
6051:
6050:
6049:
6048:
6043:
6038:
6033:
6028:
6023:
6018:
6007:
6005:
6001:
6000:
5998:
5997:
5996:
5995:
5990:
5985:
5980:
5969:
5967:
5963:
5962:
5960:
5959:
5958:
5957:
5949:
5944:
5939:
5928:
5926:
5922:
5921:
5919:
5918:
5917:
5916:
5911:
5906:
5901:
5894:
5893:
5892:
5887:
5882:
5875:
5874:
5873:
5868:
5861:
5860:
5859:
5854:
5849:
5844:
5837:
5836:
5835:
5830:
5825:
5820:
5815:
5804:
5802:
5798:
5797:
5795:
5794:
5793:
5792:
5787:
5782:
5771:
5769:
5765:
5764:
5762:
5761:
5760:
5759:
5747:
5745:
5741:
5740:
5738:
5737:
5736:
5735:
5724:
5722:
5718:
5717:
5715:
5714:
5713:
5712:
5700:
5698:
5690:
5689:
5686:
5679:
5678:
5675:
5674:
5671:
5670:
5668:
5667:
5666:
5665:
5660:
5655:
5650:
5645:
5640:
5635:
5630:
5625:
5620:
5609:
5607:
5603:
5602:
5600:
5599:
5598:
5597:
5592:
5587:
5582:
5571:
5569:
5565:
5564:
5562:
5561:
5560:
5559:
5554:
5539:
5537:
5533:
5532:
5530:
5529:
5528:
5527:
5522:
5517:
5512:
5507:
5502:
5491:
5489:
5485:
5484:
5482:
5481:
5480:
5479:
5474:
5469:
5464:
5459:
5454:
5449:
5444:
5439:
5434:
5429:
5418:
5416:
5412:
5411:
5409:
5408:
5407:
5406:
5401:
5396:
5391:
5386:
5381:
5376:
5371:
5366:
5361:
5356:
5351:
5346:
5341:
5336:
5331:
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4858:
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4826:cotransporter
4820:
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4430:cotransporter
4424:
4422:
4418:
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4404:
4393:
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4286:
4285:
4280:
4275:
4270:
4265:
4260:
4255:
4250:
4245:
4240:
4235:
4228:Na/H exchanger
4224:
4222:
4218:
4217:
4215:
4214:
4213:
4212:
4207:
4202:
4191:
4189:
4185:
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4065:
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4020:
4015:
4010:
4005:
4000:
3995:
3976:
3974:
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3969:
3967:
3966:
3965:
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3816:
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3814:
3813:
3808:
3796:
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3790:
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3786:
3785:
3784:
3779:
3774:
3769:
3764:
3759:
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3739:
3734:
3729:
3724:
3719:
3708:
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3701:
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3686:
3681:
3676:
3671:
3666:
3655:
3653:
3645:
3644:
3641:
3630:
3629:
3626:
3619:
3618:
3610:solute carrier
3597:
3595:
3594:
3587:
3580:
3572:
3563:
3562:
3554:
3551:
3550:
3548:
3547:
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3527:
3521:
3516:
3511:
3505:
3500:
3495:
3489:
3484:
3478:
3473:
3468:
3463:
3458:
3452:
3442:
3441:
3431:
3430:
3426:
3425:
3414:
3413:
3408:
3401:
3400:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3338:
3337:
3330:
3329:
3324:
3318:H/K exchanging
3315:
3308:
3307:
3302:
3297:
3292:
3287:
3282:
3277:
3272:
3267:
3256:
3254:
3247:
3246:
3243:
3242:
3239:
3237:
3231:
3230:
3228:
3227:
3221:
3220:
3215:
3210:
3205:
3200:
3195:
3190:
3185:
3180:
3175:
3170:
3165:
3160:
3155:
3150:
3145:
3140:
3135:
3130:
3125:
3120:
3115:
3110:
3105:
3095:
3093:
3087:
3086:
3084:
3083:
3078:
3073:
3068:
3063:
3058:
3053:
3048:
3043:
3038:
3033:
3028:
3023:
3018:
3013:
3008:
3003:
2998:
2991:
2989:
2980:
2974:
2973:
2951:
2949:
2948:
2941:
2934:
2926:
2920:
2919:
2909:
2897:
2896:External links
2894:
2892:
2891:
2881:(6): 703–705.
2870:
2840:(2): 275–283.
2825:
2807:(1–2): 95–98.
2795:
2757:
2714:
2676:
2656:(2): 305–310.
2641:
2606:
2586:(5): 590–593.
2571:
2536:
2493:
2458:
2436:10.1038/ng.118
2430:(5): 592–599.
2415:
2378:
2343:
2317:(6): 900–907.
2306:
2296:(4): 391–396.
2285:
2259:(3): 218–221.
2247:
2221:(6): 507–514.
2209:
2207:
2204:
2202:
2201:
2144:
2125:(3): 413–418.
2108:
2085:10.1038/ng.118
2079:(5): 592–599.
2059:
2032:(3): 475–483.
2012:
1976:
1935:
1914:(2): 160–169.
1894:
1853:
1812:
1763:
1704:
1655:
1601:
1582:(3): 486–493.
1562:
1544:
1526:
1505:
1483:
1481:
1478:
1477:
1476:
1467:
1465:Blood pressure
1462:
1453:
1440:
1435:
1428:
1425:
1373:
1370:
1346:blood pressure
1341:
1338:
1310:
1307:
1305:
1302:
1286:angiotensin II
1256:basal membrane
1238:
1235:
1183:encodes for a
1147:
1144:
1059:
1058:
1055:
1054:
1049:
1039:
1038:
1032:
1031:
1028:
1027:
1025:
1023:
1016:
1015:
1008:
1001:
997:
996:
993:
992:
978:
977:
971:
968:
967:
949:
948:
942:
938:
937:
934:
933:
919:
918:
912:
909:
908:
890:
889:
883:
879:
878:
875:
874:
866:
865:
859:
856:
855:
847:
846:
840:
834:
833:
830:
829:
821:
820:
814:
811:
810:
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801:
795:
789:
788:
785:
784:
776:
775:
769:
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765:
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756:
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744:
743:
738:
733:
729:
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718:
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683:
678:
673:
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663:
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631:
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627:
622:
617:
612:
607:
602:
597:
591:
589:
585:
584:
582:
581:
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571:
566:
561:
556:
551:
546:
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533:
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510:
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448:
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415:
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410:
406:
402:
398:
394:
390:
386:
382:
378:
374:
371:
370:
358:
357:
349:
338:
332:
331:
328:RNA expression
320:
319:
316:
315:
307:
303:
302:
294:
291:
286:
280:
279:
270:
263:
257:
253:
252:
247:
241:
240:
232:
231:
219:
218:
215:
214:
206:
202:
201:
193:
190:
185:
179:
178:
169:
162:
156:
152:
151:
144:
138:
137:
129:
128:
116:
115:
72:
68:
67:
59:
51:
50:
46:
45:
37:
36:
28:
24:
14:
13:
10:
9:
6:
4:
3:
2:
6697:
6686:
6683:
6681:
6678:
6677:
6675:
6662:
6661:
6654:
6640:
6637:
6635:
6632:
6628:
6612:
6609:
6608:
6607:
6604:
6602:
6599:
6598:
6596:
6594:
6590:
6582:
6579:
6577:
6574:
6573:
6572:
6569:
6567:
6564:
6562:
6559:
6557:
6554:
6552:
6545:
6543:
6540:
6539:
6537:
6535:
6534:Cotransporter
6531:
6527:
6523:
6519:
6514:
6510:
6492:
6489:
6487:
6484:
6482:
6479:
6477:
6474:
6472:
6469:
6467:
6464:
6463:
6460:
6453:
6449:
6435:
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6429:
6425:
6417:
6414:
6412:
6409:
6408:
6407:
6404:
6403:
6401:
6397:
6389:
6386:
6384:
6381:
6380:
6379:
6376:
6375:
6373:
6369:
6361:
6358:
6356:
6353:
6351:
6348:
6346:
6343:
6342:
6341:
6338:
6337:
6335:
6331:
6323:
6320:
6318:
6315:
6313:
6310:
6308:
6305:
6303:
6300:
6299:
6298:
6295:
6294:
6292:
6288:
6280:
6277:
6275:
6272:
6270:
6267:
6266:
6265:
6262:
6261:
6259:
6255:
6247:
6244:
6242:
6239:
6237:
6234:
6233:
6232:
6229:
6228:
6226:
6222:
6214:
6211:
6209:
6206:
6204:
6201:
6200:
6199:
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6195:
6193:
6189:
6185:
6178:
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6147:
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6120:
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6115:
6112:
6110:
6107:
6105:
6102:
6100:
6097:
6095:
6092:
6090:
6087:
6085:
6082:
6080:
6077:
6075:
6072:
6070:
6067:
6066:
6065:
6062:
6061:
6059:
6055:
6047:
6044:
6042:
6039:
6037:
6034:
6032:
6029:
6027:
6024:
6022:
6019:
6017:
6014:
6013:
6012:
6009:
6008:
6006:
6002:
5994:
5991:
5989:
5986:
5984:
5981:
5979:
5976:
5975:
5974:
5971:
5970:
5968:
5964:
5956:
5953:
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5948:
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5943:
5940:
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5935:
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5933:
5930:
5929:
5927:
5923:
5915:
5912:
5910:
5907:
5905:
5902:
5900:
5897:
5896:
5895:
5891:
5888:
5886:
5883:
5881:
5878:
5877:
5876:
5872:
5869:
5867:
5864:
5863:
5862:
5858:
5855:
5853:
5850:
5848:
5845:
5843:
5840:
5839:
5838:
5834:
5831:
5829:
5826:
5824:
5821:
5819:
5816:
5814:
5811:
5810:
5809:
5806:
5805:
5803:
5799:
5791:
5788:
5786:
5783:
5781:
5778:
5777:
5776:
5773:
5772:
5770:
5766:
5758:
5755:
5754:
5752:
5749:
5748:
5746:
5742:
5734:
5731:
5730:
5729:
5726:
5725:
5723:
5719:
5711:
5708:
5707:
5705:
5702:
5701:
5699:
5695:
5691:
5684:
5680:
5664:
5661:
5659:
5656:
5654:
5651:
5649:
5646:
5644:
5641:
5639:
5636:
5634:
5631:
5629:
5626:
5624:
5621:
5619:
5616:
5615:
5614:
5611:
5610:
5608:
5604:
5596:
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5577:
5576:
5573:
5572:
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5526:
5523:
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5518:
5516:
5513:
5511:
5508:
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5503:
5501:
5498:
5497:
5496:
5493:
5492:
5490:
5486:
5478:
5475:
5473:
5470:
5468:
5465:
5463:
5460:
5458:
5455:
5453:
5450:
5448:
5445:
5443:
5440:
5438:
5435:
5433:
5430:
5428:
5425:
5424:
5423:
5420:
5419:
5417:
5413:
5405:
5402:
5400:
5397:
5395:
5392:
5390:
5387:
5385:
5382:
5380:
5377:
5375:
5372:
5370:
5367:
5365:
5362:
5360:
5357:
5355:
5352:
5350:
5347:
5345:
5342:
5340:
5337:
5335:
5332:
5330:
5327:
5325:
5322:
5320:
5317:
5315:
5312:
5310:
5307:
5305:
5302:
5300:
5297:
5295:
5292:
5290:
5287:
5285:
5282:
5280:
5277:
5275:
5272:
5270:
5267:
5265:
5262:
5260:
5257:
5255:
5252:
5250:
5247:
5245:
5242:
5240:
5237:
5235:
5232:
5230:
5227:
5225:
5222:
5220:
5217:
5215:
5212:
5210:
5207:
5205:
5202:
5200:
5197:
5195:
5192:
5190:
5187:
5185:
5182:
5180:
5177:
5176:
5175:
5172:
5171:
5169:
5165:
5157:
5154:
5152:
5149:
5147:
5144:
5142:
5139:
5137:
5134:
5132:
5129:
5128:
5127:
5124:
5123:
5121:
5117:
5109:
5106:
5104:
5101:
5099:
5096:
5094:
5091:
5090:
5089:
5086:
5085:
5083:
5079:
5071:
5068:
5066:
5063:
5061:
5058:
5056:
5053:
5051:
5048:
5046:
5043:
5041:
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5013:
5011:
5008:
5006:
5003:
5001:
4998:
4996:
4993:
4991:
4988:
4986:
4983:
4981:
4978:
4976:
4973:
4972:
4971:
4968:
4967:
4965:
4961:
4952:
4948:
4945:
4944:
4943:
4939:
4936:
4934:
4931:
4930:
4929:
4925:
4922:
4921:
4920:
4916:
4913:
4911:
4908:
4907:
4906:
4902:
4899:
4897:
4894:
4892:
4889:
4887:
4884:
4882:
4879:
4878:
4877:
4874:
4873:
4871:
4867:
4863:
4856:
4852:
4836:
4833:
4831:
4828:
4827:
4825:
4822:
4821:
4819:
4815:
4807:
4804:
4802:
4799:
4797:
4794:
4793:
4791:
4787:
4784:
4783:
4781:
4777:
4769:
4766:
4764:
4761:
4759:
4756:
4755:
4754:
4751:
4750:
4748:
4744:
4736:
4733:
4731:
4728:
4726:
4723:
4721:
4718:
4716:
4713:
4711:
4708:
4706:
4703:
4701:
4698:
4696:
4693:
4692:
4691:
4688:
4687:
4685:
4681:
4673:
4670:
4668:
4665:
4663:
4660:
4658:
4655:
4653:
4650:
4648:
4645:
4643:
4640:
4638:
4635:
4633:
4630:
4628:
4625:
4623:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4604:
4602:
4599:
4598:
4596:
4592:
4584:
4581:
4579:
4576:
4574:
4571:
4569:
4566:
4565:
4564:
4561:
4560:
4558:
4554:
4546:
4543:
4541:
4538:
4537:
4536:
4533:
4532:
4530:
4526:
4518:
4515:
4513:
4510:
4508:
4505:
4503:
4500:
4498:
4495:
4494:
4493:
4490:
4489:
4487:
4483:
4475:
4472:
4470:
4467:
4465:
4462:
4460:
4457:
4455:
4452:
4450:
4447:
4445:
4442:
4440:
4437:
4435:
4432:
4431:
4429:
4426:
4425:
4423:
4419:
4411:
4408:
4405:
4403:
4400:
4399:
4398:
4395:
4394:
4392:
4388:
4384:
4377:
4373:
4359:
4356:
4354:
4351:
4349:
4346:
4344:
4341:
4337:
4334:
4332:
4329:
4327:
4324:
4322:
4319:
4317:
4314:
4312:
4309:
4307:
4304:
4303:
4302:
4299:
4298:
4296:
4292:
4284:
4281:
4279:
4276:
4274:
4271:
4269:
4266:
4264:
4261:
4259:
4256:
4254:
4251:
4249:
4246:
4244:
4241:
4239:
4236:
4234:
4231:
4230:
4229:
4226:
4225:
4223:
4219:
4211:
4208:
4206:
4203:
4201:
4198:
4197:
4196:
4193:
4192:
4190:
4186:
4178:
4175:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4155:
4153:
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4134:
4133:
4129:
4125:
4122:
4120:
4117:
4115:
4112:
4110:
4107:
4106:
4104:
4103:
4101:
4097:
4089:
4086:
4084:
4081:
4079:
4076:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4054:
4051:
4049:
4046:
4044:
4041:
4039:
4036:
4034:
4031:
4029:
4026:
4024:
4021:
4019:
4016:
4014:
4011:
4009:
4006:
4004:
4001:
3999:
3996:
3994:
3991:
3990:
3989:
3985:
3981:
3978:
3977:
3975:
3971:
3963:
3960:
3958:
3955:
3953:
3950:
3948:
3945:
3943:
3940:
3938:
3935:
3933:
3930:
3928:
3925:
3923:
3920:
3918:
3915:
3913:
3910:
3908:
3905:
3904:
3903:
3900:
3899:
3897:
3893:
3885:
3882:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3831:
3830:
3827:
3826:
3824:
3820:
3812:
3809:
3807:
3804:
3803:
3802:
3798:
3797:
3795:
3791:
3783:
3780:
3778:
3775:
3773:
3770:
3768:
3765:
3763:
3760:
3758:
3755:
3753:
3750:
3748:
3745:
3743:
3740:
3738:
3735:
3733:
3730:
3728:
3725:
3723:
3720:
3718:
3715:
3714:
3713:
3710:
3709:
3707:
3703:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3675:
3672:
3670:
3667:
3665:
3662:
3661:
3660:
3657:
3656:
3654:
3650:
3646:
3639:
3635:
3631:
3624:
3620:
3615:
3611:
3608:
3604:
3600:
3593:
3588:
3586:
3581:
3579:
3574:
3573:
3570:
3560:
3559:
3552:
3546:
3543:
3541:
3538:
3536:
3533:
3531:
3528:
3526:
3522:
3520:
3517:
3515:
3512:
3510:
3506:
3504:
3501:
3499:
3496:
3494:
3490:
3488:
3485:
3483:
3479:
3477:
3474:
3472:
3469:
3467:
3464:
3462:
3459:
3457:
3453:
3451:
3447:
3444:
3443:
3440:
3436:
3433:
3432:
3428:
3427:
3424:
3420:
3416:
3415:
3412:
3409:
3407:
3403:
3402:
3399:
3396:
3394:
3391:
3389:
3386:
3384:
3381:
3379:
3376:
3374:
3371:
3369:
3366:
3364:
3360:
3356:
3352:
3348:
3344:
3340:
3339:
3336:
3332:
3331:
3328:
3325:
3323:
3319:
3316:
3314:
3310:
3309:
3306:
3303:
3301:
3298:
3296:
3293:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3266:
3262:
3258:
3257:
3255:
3252:
3251:P-type ATPase
3248:
3238:
3236:
3232:
3226:
3223:
3222:
3219:
3216:
3214:
3211:
3209:
3206:
3204:
3201:
3199:
3196:
3194:
3191:
3189:
3186:
3184:
3181:
3179:
3176:
3174:
3171:
3169:
3166:
3164:
3161:
3159:
3156:
3154:
3151:
3149:
3146:
3144:
3141:
3139:
3136:
3134:
3131:
3129:
3126:
3124:
3121:
3119:
3116:
3114:
3111:
3109:
3106:
3104:
3100:
3097:
3096:
3094:
3092:
3088:
3082:
3079:
3077:
3074:
3072:
3069:
3067:
3064:
3062:
3059:
3057:
3054:
3052:
3049:
3047:
3044:
3042:
3039:
3037:
3034:
3032:
3029:
3027:
3024:
3022:
3019:
3017:
3014:
3012:
3009:
3007:
3004:
3002:
2999:
2997:
2993:
2992:
2990:
2988:
2984:
2981:
2979:
2975:
2970:
2966:
2962:
2958:
2954:
2947:
2942:
2940:
2935:
2933:
2928:
2927:
2924:
2917:
2913:
2910:
2907:
2903:
2900:
2899:
2895:
2888:
2884:
2880:
2876:
2871:
2867:
2863:
2858:
2853:
2848:
2843:
2839:
2835:
2831:
2826:
2822:
2818:
2814:
2810:
2806:
2802:
2796:
2792:
2788:
2784:
2780:
2776:
2772:
2768:
2764:
2758:
2754:
2750:
2745:
2740:
2736:
2732:
2728:
2724:
2720:
2715:
2711:
2707:
2703:
2699:
2695:
2691:
2687:
2683:
2677:
2673:
2669:
2664:
2659:
2655:
2651:
2647:
2642:
2638:
2634:
2629:
2624:
2620:
2616:
2612:
2607:
2603:
2599:
2594:
2589:
2585:
2581:
2577:
2572:
2568:
2564:
2559:
2554:
2550:
2546:
2542:
2537:
2533:
2529:
2524:
2519:
2515:
2511:
2507:
2503:
2499:
2494:
2490:
2486:
2481:
2476:
2472:
2468:
2464:
2459:
2455:
2451:
2446:
2441:
2437:
2433:
2429:
2425:
2421:
2416:
2412:
2408:
2404:
2400:
2396:
2392:
2388:
2384:
2379:
2375:
2371:
2366:
2361:
2357:
2353:
2349:
2344:
2340:
2336:
2332:
2328:
2324:
2320:
2316:
2312:
2307:
2303:
2299:
2295:
2291:
2286:
2282:
2278:
2274:
2270:
2266:
2262:
2258:
2254:
2248:
2244:
2240:
2236:
2232:
2228:
2224:
2220:
2216:
2211:
2210:
2205:
2197:
2193:
2188:
2183:
2179:
2175:
2171:
2167:
2163:
2159:
2155:
2148:
2145:
2140:
2136:
2132:
2128:
2124:
2120:
2112:
2109:
2104:
2100:
2095:
2090:
2086:
2082:
2078:
2074:
2070:
2063:
2060:
2055:
2051:
2047:
2043:
2039:
2035:
2031:
2027:
2019:
2017:
2013:
2008:
2004:
2000:
1996:
1992:
1988:
1980:
1977:
1972:
1968:
1963:
1958:
1954:
1950:
1946:
1939:
1936:
1931:
1927:
1922:
1917:
1913:
1909:
1905:
1898:
1895:
1890:
1886:
1881:
1876:
1872:
1868:
1864:
1857:
1854:
1849:
1845:
1840:
1835:
1831:
1827:
1823:
1816:
1813:
1808:
1804:
1799:
1794:
1790:
1786:
1782:
1778:
1774:
1767:
1764:
1759:
1755:
1750:
1745:
1740:
1735:
1731:
1727:
1723:
1719:
1715:
1708:
1705:
1700:
1696:
1691:
1686:
1682:
1678:
1674:
1670:
1666:
1659:
1656:
1651:
1647:
1642:
1637:
1632:
1627:
1623:
1619:
1615:
1608:
1606:
1602:
1597:
1593:
1589:
1585:
1581:
1577:
1569:
1567:
1563:
1558:
1554:
1548:
1545:
1540:
1536:
1530:
1527:
1523:
1519:
1514:
1512:
1510:
1506:
1502:
1498:
1493:
1491:
1489:
1485:
1479:
1475:
1471:
1468:
1466:
1463:
1461:
1457:
1456:Cotransporter
1454:
1452:
1448:
1444:
1441:
1439:
1436:
1434:
1431:
1430:
1426:
1424:
1422:
1421:
1416:
1415:
1410:
1409:
1404:
1403:
1398:
1394:
1390:
1386:
1382:
1378:
1371:
1369:
1367:
1363:
1358:
1356:
1352:
1347:
1339:
1337:
1335:
1331:
1327:
1323:
1318:
1316:
1308:
1303:
1301:
1299:
1295:
1291:
1287:
1282:
1280:
1276:
1271:
1269:
1265:
1261:
1257:
1252:
1248:
1244:
1236:
1234:
1232:
1228:
1224:
1220:
1218:
1214:
1210:
1206:
1202:
1198:
1194:
1190:
1186:
1182:
1179:
1178:
1173:
1169:
1165:
1161:
1157:
1153:
1145:
1143:
1141:
1136:
1134:
1130:
1127:
1126:
1121:
1117:
1113:
1109:
1108:tubular fluid
1105:
1102:
1098:
1094:
1090:
1089:cotransporter
1086:
1082:
1078:
1074:
1070:
1066:
1053:
1048:
1044:
1040:
1037:
1033:
1026:
1024:
1021:
1017:
1013:
1009:
1006:
1002:
998:
991:
989:
985:
979:
975:
972:
966:
964:
960:
956:
950:
946:
943:
939:
932:
930:
926:
920:
916:
913:
907:
905:
901:
897:
891:
887:
884:
882:RefSeq (mRNA)
880:
873:
872:
867:
863:
860:
854:
853:
848:
844:
841:
839:
835:
828:
827:
822:
818:
815:
809:
808:
803:
799:
796:
794:
790:
783:
782:
777:
773:
770:
764:
763:
758:
754:
751:
749:
745:
742:
739:
737:
734:
730:
727:
723:
719:
712:
708:
703:
697:
694:
692:
689:
687:
684:
682:
679:
677:
674:
672:
669:
667:
664:
662:
659:
657:
654:
652:
649:
647:
646:ion transport
644:
642:
639:
638:
636:
633:
632:
626:
623:
621:
618:
616:
613:
611:
608:
606:
603:
601:
598:
596:
593:
592:
590:
587:
586:
580:
577:
575:
572:
570:
567:
565:
562:
560:
557:
555:
552:
550:
547:
545:
542:
541:
539:
536:
535:
532:
531:Gene ontology
528:
524:
512:
507:
504:
502:
498:
490:
485:
474:
470:
466:
462:
458:
454:
450:
447:distal tubule
446:
442:
438:
437:
434:
430:
425:
422:
412:
408:
404:
400:
396:
393:renal medulla
392:
388:
384:
380:
377:kidney tubule
376:
375:
372:
368:
363:
360:
359:
356:
354:
350:
348:
347:
343:
342:
339:
337:
333:
329:
325:
321:
313:
308:
304:
300:
295:
285:
281:
274:
267:
261:
254:
246:
242:
238:
233:
229:
224:
220:
212:
207:
203:
199:
194:
184:
180:
173:
166:
160:
153:
149:
143:
139:
135:
130:
126:
121:
117:
113:
109:
105:
101:
97:
93:
89:
85:
81:
77:
69:
64:
57:
52:
47:
43:
38:
33:
27:
19:
6657:
6555:
5753:transporter
5706:transporter
4792:transporter
4603:transporter
4443:
3986:- dependent
3555:
2965:ATP synthase
2878:
2874:
2837:
2833:
2804:
2800:
2766:
2762:
2729:(1): 26–33.
2726:
2722:
2688:(1): 52–58.
2685:
2681:
2653:
2649:
2618:
2614:
2583:
2579:
2548:
2544:
2508:(1): 82–92.
2505:
2501:
2470:
2466:
2427:
2423:
2389:(3): 29–36.
2386:
2382:
2355:
2351:
2314:
2310:
2293:
2289:
2256:
2252:
2218:
2214:
2161:
2157:
2147:
2122:
2118:
2111:
2076:
2072:
2062:
2029:
2025:
1990:
1986:
1979:
1952:
1948:
1938:
1911:
1907:
1897:
1873:(1): 66–76.
1870:
1866:
1856:
1829:
1825:
1815:
1783:(1): 82–92.
1780:
1776:
1766:
1721:
1717:
1707:
1672:
1668:
1658:
1621:
1617:
1579:
1575:
1556:
1547:
1538:
1529:
1458:, including
1443:Electrolytes
1418:
1412:
1406:
1400:
1396:
1375:
1359:
1343:
1319:
1312:
1283:
1272:
1240:
1221:
1213:crystallized
1175:
1149:
1137:
1123:
1084:
1080:
1079:, or as the
1076:
1072:
1068:
1064:
1062:
984:NP_001192240
981:
963:NP_001119580
959:NP_001119579
952:
925:NM_001205311
922:
904:NM_001126108
900:NM_001126107
893:
869:
850:
824:
805:
779:
760:
740:
735:
451:renal cortex
443:human kidney
439:right kidney
381:human kidney
351:
344:
71:External IDs
26:
5613:zinc efflux
3417:3.A.3.8.8:
3311:3.A.3.1.2:
3259:3.A.3.1.1:
1395:within the
1330:splice site
1294:vasopressin
1290:aldosterone
471:metanephros
467:bone marrow
459:granulocyte
401:granulocyte
310:95,092,842
297:95,055,829
209:56,915,850
196:56,865,207
49:Identifiers
6674:Categories
6639:Cl-oxalate
6634:Cl-formate
6561:Na/glucose
5751:Acetyl-CoA
3091:H (V-type)
2987:H (F-type)
2969:TC 3A2-3A3
2857:2066/80977
2682:Nephrology
1524:, May 2017
1503:, May 2017
1480:References
1445:, such as
1326:frameshift
1264:glomerulus
1217:homodimers
1189:amino acid
405:lymph node
389:glomerulus
355:(ortholog)
92:HomoloGene
6658:see also
6530:Symporter
6518:Ion pumps
3556:see also
3523:type 13:
3341:3.A.3.2:
2957:ion pumps
2054:205630437
1474:thiazides
1470:Diuretics
1460:symporter
1393:mutations
1355:wild-type
1304:Pathology
1298:thiazides
1106:from the
988:NP_062288
955:NP_000330
929:NM_019415
896:NM_000339
726:Orthologs
671:transport
100:GeneCards
6627:(Band 3)
6611:Na/(Ca-K
6181:SLC41–48
6134:SLC39A14
6129:SLC39A13
6124:SLC39A12
6119:SLC39A11
6114:SLC39A10
6046:SLC38A10
5687:SLC31–40
5663:SLC30A10
5477:SLC26A11
5472:SLC26A10
5404:SLC25A46
5399:SLC25A45
5394:SLC25A44
5389:SLC25A43
5384:SLC25A42
5379:SLC25A41
5374:SLC25A40
5369:SLC25A39
5364:SLC25A38
5359:SLC25A37
5354:SLC25A36
5349:SLC25A35
5344:SLC25A34
5339:SLC25A33
5334:SLC25A32
5329:SLC25A31
5324:SLC25A30
5319:SLC25A29
5314:SLC25A28
5309:SLC25A27
5304:SLC25A26
5299:SLC25A25
5294:SLC25A24
5289:SLC25A23
5284:SLC25A22
5279:SLC25A21
5274:SLC25A20
5269:SLC25A19
5264:SLC25A18
5259:SLC25A17
5254:SLC25A16
5249:SLC25A15
5244:SLC25A14
5239:SLC25A13
5234:SLC25A12
5229:SLC25A11
5224:SLC25A10
5070:SLC22A20
5065:SLC22A19
5060:SLC22A18
5055:SLC22A17
5050:SLC22A16
5045:SLC22A15
5040:SLC22A14
5035:SLC22A13
5030:SLC22A12
5025:SLC22A11
5020:SLC22A10
4859:SLC21–30
4790:thiamine
4672:SLC16A14
4667:SLC16A13
4662:SLC16A12
4657:SLC16A11
4652:SLC16A10
4380:SLC11–20
3984:chloride
3627:By group
3419:flippase
3235:A-ATPase
3218:ATP6V0E1
3208:ATP6V0D2
3203:ATP6V0D1
3188:ATP6V0A4
3183:ATP6V0A2
3178:ATP6V0A1
3168:ATP6V1G3
3163:ATP6V1G2
3158:ATP6V1G1
3148:ATP6V1E2
3143:ATP6V1E1
3133:ATP6V1C2
3128:ATP6V1C1
3123:ATP6V1B2
3118:ATP6V1B1
2887:18067089
2866:19451210
2821:17997379
2791:33009059
2783:18270262
2753:20031564
2710:38008467
2702:19207868
2672:18362449
2637:18263927
2602:19668106
2567:19033254
2532:19875813
2489:18469313
2454:18391953
2411:25283004
2403:18287808
2374:19779464
2339:19321638
2331:18580052
2302:19489442
2281:41050205
2273:19420906
2235:18496130
2196:22266938
2139:17981812
2103:18391953
2046:21157372
2007:15068971
1971:12039972
1930:20445498
1889:20720527
1848:16887815
1807:19875813
1758:16275913
1699:19474192
1650:18667063
1576:Genomics
1520:–
1499:–
1451:chloride
1427:See also
1362:carriers
1351:controls
1322:nonsense
1237:Function
1101:chloride
1036:Wikidata
705:Sources:
625:membrane
6542:Na/K,Cl
6456:SLCO1–4
6416:SLC47A2
6411:SLC47A1
6388:SLC46A2
6383:SLC46A1
6360:SLC45A4
6355:SLC54A3
6350:SLC45A2
6345:SLC45A1
6322:SLC44A5
6317:SLC44A4
6312:SLC44A3
6307:SLC44A2
6302:SLC44A1
6279:SLC43A3
6274:SLC43A2
6269:SLC43A1
6213:SLC41A3
6208:SLC41A2
6203:SLC41A1
6157:SLC40A1
6109:SLC39A9
6104:SLC39A8
6099:SLC39A7
6094:SLC39A6
6089:SLC39A5
6084:SLC39A4
6079:SLC39A3
6074:SLC39A2
6069:SLC39A1
6041:SLC38A6
6036:SLC38A5
6031:SLC38A4
6026:SLC38A3
6021:SLC38A2
6016:SLC38A1
5993:SLC37A4
5988:SLC37A3
5983:SLC37A2
5978:SLC37A1
5952:SLC36A4
5947:SLC36A3
5942:SLC36A2
5937:SLC36A1
5914:SLC35E4
5909:SLC35E3
5904:SLC35E2
5899:SLC35E1
5890:SLC35D3
5885:SLC35D2
5880:SLC35D1
5871:SLC35C2
5866:SLC35C1
5857:SLC35B4
5852:SLC35B3
5847:SLC35B2
5842:SLC35B1
5833:SLC35A5
5828:SLC35A4
5823:SLC35A3
5818:SLC35A2
5813:SLC35A1
5790:SLC34A3
5785:SLC34A2
5780:SLC34A1
5757:SLC33A1
5733:SLC32A1
5710:SLC31A1
5658:SLC30A9
5653:SLC30A8
5648:SLC30A7
5643:SLC30A6
5638:SLC30A5
5633:SLC30A4
5628:SLC30A3
5623:SLC30A2
5618:SLC30A1
5595:SLC29A4
5590:SLC29A3
5585:SLC29A2
5580:SLC29A1
5557:SLC28A3
5552:SLC28A2
5547:SLC28A1
5525:SLC27A6
5520:SLC27A5
5515:SLC27A4
5510:SLC27A3
5505:SLC27A2
5500:SLC27A1
5467:SLC26A9
5462:SLC26A8
5457:SLC26A7
5452:SLC26A6
5447:SLC26A5
5442:SLC26A4
5437:SLC26A3
5432:SLC26A2
5427:SLC26A1
5219:SLC25A9
5214:SLC25A8
5209:SLC25A7
5204:SLC25A6
5199:SLC25A5
5194:SLC25A4
5189:SLC25A3
5184:SLC25A2
5179:SLC25A1
5156:SLC24A6
5151:SLC24A5
5146:SLC24A4
5141:SLC24A3
5136:SLC24A2
5131:SLC24A1
5108:SLC23A4
5103:SLC23A3
5098:SLC23A2
5093:SLC23A1
5015:SLC22A9
5010:SLC22A8
5005:SLC22A7
5000:SLC22A6
4995:SLC22A5
4990:SLC22A4
4985:SLC22A3
4980:SLC22A2
4975:SLC22A1
4951:SLCO6A1
4947:SLCO5A1
4938:SLCO4C1
4933:SLCO4A1
4924:SLCO3A1
4915:SLCO2B1
4910:SLCO2A1
4901:SLCO1C1
4896:SLCO1B4
4891:SLCO1B3
4886:SLCO1B1
4881:SLCO1A2
4835:SLC20A2
4830:SLC20A1
4806:SLC19A3
4801:SLC19A2
4796:SLC19A1
4768:SLC18A3
4763:SLC18A2
4758:SLC18A1
4735:SLC17A9
4730:SLC17A8
4725:SLC17A7
4720:SLC17A6
4715:SLC17A5
4710:SLC17A4
4705:SLC17A3
4700:SLC17A2
4695:SLC17A1
4647:SLC16A9
4642:SLC16A8
4637:SLC16A7
4632:SLC16A6
4627:SLC16A5
4622:SLC16A4
4617:SLC16A3
4612:SLC16A2
4607:SLC16A1
4583:SLC15A4
4578:SLC15A3
4573:SLC15A2
4568:SLC15A1
4545:SLC14A2
4540:SLC14A1
4517:SLC13A5
4512:SLC13A4
4507:SLC13A3
4502:SLC13A2
4497:SLC13A1
4474:SLC12A9
4469:SLC12A8
4464:SLC12A7
4459:SLC12A6
4454:SLC12A5
4449:SLC12A4
4444:SLC12A3
4439:SLC12A2
4434:SLC12A1
4407:SLC11A2
4402:SLC11A1
4336:SLC10A7
4331:SLC10A6
4326:SLC10A5
4321:SLC10A4
4316:SLC10A3
4311:SLC10A2
4306:SLC10A1
4283:SLC9A11
4278:SLC9A10
4177:SLC7A14
4172:SLC7A13
4167:SLC7A11
4162:SLC7A10
4088:SLC6A20
4083:SLC6A19
4078:SLC6A18
4073:SLC6A17
4068:SLC6A16
4063:SLC6A15
4058:SLC6A14
4053:SLC6A13
4048:SLC6A12
4043:SLC6A11
4038:SLC6A10
3642:SLC1–10
3545:ATP13A5
3540:ATP13A4
3535:ATP13A3
3530:ATP13A2
3525:ATP13A1
3253:(3.A.3)
3213:ATP6V0E
3198:ATP6V0C
3193:ATP6V0B
3173:ATP6V1H
3153:ATP6V1F
3138:ATP6V1D
3113:ATP6V1A
3108:ATP6AP2
3103:ATP6AP1
2961:ATPases
2744:2729193
2523:2799281
2445:3766631
2243:1251203
2187:3278668
2166:Bibcode
2094:3766631
1798:2799281
1749:1283841
1726:Bibcode
1690:3350128
1641:2518128
1596:8812482
1522:Ensembl
1501:Ensembl
1433:Nephron
1397:SLC12A3
1366:alleles
1185:protein
1177:SLC12A3
1125:SLC12A3
1116:nephron
1114:of the
1091:in the
1087:) is a
838:UniProt
793:Ensembl
732:Species
711:QuickGO
600:cytosol
330:pattern
104:SLC12A3
63:SLC12A3
56:Aliases
35:SLC12A3
5704:copper
4786:folate
4273:SLC9A9
4268:SLC9A8
4263:SLC9A7
4258:SLC9A6
4253:SLC9A5
4248:SLC9A4
4243:SLC9A3
4238:SLC9A2
4233:SLC9A1
4210:SLC8A3
4205:SLC8A2
4200:SLC8A1
4157:SLC7A9
4152:SLC7A8
4147:SLC7A7
4142:SLC7A6
4137:SLC7A5
4124:SLC7A4
4119:SLC7A3
4114:SLC7A2
4109:SLC7A1
4033:SLC6A9
4028:SLC6A8
4023:SLC6A7
4018:SLC6A6
4013:SLC6A5
4008:SLC6A4
4003:SLC6A3
3998:SLC6A2
3993:SLC6A1
3982:- and
3980:sodium
3907:SLC5A1
3834:SLC4A1
3806:SLC3A1
3717:SLC2A1
3664:SLC1A1
3519:ATP11C
3514:ATP11B
3509:ATP11A
3503:ATP10D
3498:ATP10B
3493:ATP10A
3476:ATP8B4
3471:ATP8B3
3466:ATP8B2
3461:ATP8B1
3456:ATP8A1
3423:ATP8A2
3398:ATP2C1
3393:ATP2B4
3388:ATP2B3
3383:ATP2B2
3378:ATP2B1
3373:ATP2A3
3368:ATP2A2
3363:ATP2A1
3335:ATP12A
3305:ATP1G1
3300:ATP1B4
3295:ATP1B3
3290:ATP1B2
3285:ATP1B1
3280:ATP1A4
3275:ATP1A3
3270:ATP1A2
3265:ATP1A1
3225:TCIRG1
3071:ATP5L2
3061:ATP5J2
3041:ATP5G3
3036:ATP5G2
3031:ATP5G1
3026:ATP5F1
3011:ATP5C2
3006:ATP5C1
2996:ATP5A1
2918:(MeSH)
2908:(MeSH)
2885:
2864:
2819:
2789:
2781:
2751:
2741:
2708:
2700:
2670:
2635:
2600:
2565:
2530:
2520:
2487:
2452:
2442:
2409:
2401:
2372:
2337:
2329:
2300:
2279:
2271:
2241:
2233:
2194:
2184:
2158:Nature
2137:
2101:
2091:
2052:
2044:
2005:
1969:
1928:
1887:
1846:
1805:
1795:
1756:
1746:
1697:
1687:
1648:
1638:
1624:: 22.
1594:
1447:sodium
1205:amino-
1162:) and
1097:sodium
1093:kidney
1022:search
1020:PubMed
871:P59158
852:P55017
748:Entrez
501:BioGPS
413:spleen
88:108114
80:600968
6606:Na/Ca
6556:Na/Cl
6427:(48):
6399:(47):
6371:(46):
6333:(45):
6290:(44):
6257:(43):
6224:(42):
6191:(41):
6145:(40):
6057:(39):
6004:(38):
5966:(37):
5925:(36):
5801:(35):
5768:(34):
5744:(33):
5721:(32):
5697:(31):
5606:(30):
5568:(29):
5536:(28):
5488:(27):
5415:(26):
5167:(25):
5119:(24):
5081:(23):
4963:(22):
4869:(21):
4817:(20):
4779:(19):
4746:(18):
4683:(17):
4594:(16):
4556:(15):
4528:(14):
4485:(13):
4421:(12):
4390:(11):
4294:(10):
3614:TC 2A
3487:ATP9B
3482:ATP9A
3411:ATP7B
3406:ATP7A
3347:SERCA
3327:ATP4B
3322:ATP4A
3081:ATP5S
3076:ATP5O
3066:ATP5L
3056:ATP5J
3051:ATP5I
3046:ATP5H
3021:ATP5E
3016:ATP5D
3001:ATP5B
2787:S2CID
2706:S2CID
2407:S2CID
2335:S2CID
2277:S2CID
2239:S2CID
2050:S2CID
1414:KLHL3
1349:than
1133:16q13
781:20497
741:Mouse
736:Human
707:Amigo
353:Mouse
346:Human
293:Start
228:Mouse
192:Start
188:16q13
125:Human
6613:) -
6601:Na/H
6571:Cl/K
6566:Na/I
6547:Na/P
6491:O4A1
6486:O431
6481:O2B1
6476:O1B3
6471:O1B1
6466:O1A2
6246:RhCG
6241:RhBG
6236:RhAG
5955:36A2
4410:11A3
4358:10A7
4353:10A3
4348:10A2
4343:10A1
4221:(9):
4188:(8):
4099:(7):
3973:(6):
3895:(5):
3822:(4):
3793:(3):
3705:(2):
3652:(1):
3450:ATP3
3435:Na/K
3357:) /
3355:SPCA
3351:PMCA
2883:PMID
2862:PMID
2817:PMID
2779:PMID
2749:PMID
2698:PMID
2668:PMID
2633:PMID
2598:PMID
2563:PMID
2528:PMID
2485:PMID
2450:PMID
2399:PMID
2370:PMID
2327:PMID
2298:PMID
2269:PMID
2231:PMID
2192:PMID
2135:PMID
2099:PMID
2042:PMID
2003:PMID
1967:PMID
1926:PMID
1885:PMID
1844:PMID
1803:PMID
1754:PMID
1695:PMID
1646:PMID
1592:PMID
1472:and
1449:and
1420:CUL3
1417:and
1408:WNK4
1402:WNK1
1332:and
1292:and
1279:WNK4
1277:and
1275:WNK3
1207:and
1181:gene
1164:CCC9
1129:gene
1104:ions
1099:and
1077:NCCT
1063:The
762:6559
336:Bgee
284:Band
245:Chr.
183:Band
142:Chr.
76:OMIM
6617:HCO
6615:Cl/
3313:H/K
2852:hdl
2842:doi
2838:161
2809:doi
2805:388
2771:doi
2767:121
2739:PMC
2731:doi
2690:doi
2658:doi
2623:doi
2588:doi
2553:doi
2518:PMC
2510:doi
2475:doi
2440:PMC
2432:doi
2391:doi
2387:108
2360:doi
2319:doi
2261:doi
2223:doi
2182:PMC
2174:doi
2162:482
2127:doi
2089:PMC
2081:doi
2034:doi
1995:doi
1991:287
1957:doi
1916:doi
1875:doi
1834:doi
1830:281
1793:PMC
1785:doi
1744:PMC
1734:doi
1722:102
1685:PMC
1677:doi
1673:297
1636:PMC
1626:doi
1584:doi
1085:TSC
1083:or
1075:or
1073:NCC
509:n/a
306:End
205:End
108:OMA
96:287
84:MGI
6676::
6532:,
3962:12
3957:11
3952:10
3884:11
3879:10
3782:14
3777:13
3772:12
3767:11
3762:10
3605::
3601:,
3448::
3437:–
3421::
3361::
3353:,
3349:,
3343:Ca
3320::
3263::
3101::
2963:/
2959:,
2955::
2879:24
2877:.
2860:.
2850:.
2836:.
2832:.
2815:.
2803:.
2785:.
2777:.
2765:.
2747:.
2737:.
2725:.
2721:.
2704:.
2696:.
2686:14
2684:.
2666:.
2654:55
2652:.
2648:.
2631:.
2619:23
2617:.
2613:.
2596:.
2584:66
2582:.
2578:.
2561:.
2549:24
2547:.
2543:.
2526:.
2516:.
2506:21
2504:.
2500:.
2483:.
2471:23
2469:.
2465:.
2448:.
2438:.
2428:40
2426:.
2422:.
2405:.
2397:.
2385:.
2368:.
2356:22
2354:.
2350:.
2333:.
2325:.
2315:28
2313:.
2294:57
2292:.
2275:.
2267:.
2257:30
2255:.
2237:.
2229:.
2219:18
2217:.
2190:.
2180:.
2172:.
2160:.
2156:.
2133:.
2123:17
2121:.
2097:.
2087:.
2077:40
2075:.
2071:.
2048:.
2040:.
2030:29
2028:.
2015:^
2001:.
1989:.
1965:.
1953:13
1951:.
1947:.
1924:.
1912:78
1910:.
1906:.
1883:.
1871:79
1869:.
1865:.
1842:.
1828:.
1824:.
1801:.
1791:.
1781:21
1779:.
1775:.
1752:.
1742:.
1732:.
1720:.
1716:.
1693:.
1683:.
1671:.
1667:.
1644:.
1634:.
1620:.
1616:.
1604:^
1590:.
1580:35
1578:.
1565:^
1555:.
1537:.
1508:^
1487:^
1411:,
1405:,
1387:,
1383:,
1328:,
1324:,
1288:,
1233:.
1135:.
1071:,
709:/
312:bp
299:bp
211:bp
198:bp
106:;
102::
98:;
94::
90:;
86::
82:;
78::
6622:3
6581:5
6576:4
6551:3
6549:i
5545:(
4953:)
4949:(
4788:/
3947:9
3942:8
3937:7
3932:6
3927:5
3922:4
3917:3
3912:2
3874:9
3869:8
3864:7
3859:6
3854:5
3849:4
3844:3
3839:2
3811:2
3757:9
3752:8
3747:7
3742:6
3737:5
3732:4
3727:3
3722:2
3694:7
3689:6
3684:5
3679:4
3674:3
3669:2
3616:)
3612:(
3591:e
3584:t
3577:v
3439:H
3345:(
2971:)
2967:(
2945:e
2938:t
2931:v
2889:.
2868:.
2854::
2844::
2823:.
2811::
2793:.
2773::
2755:.
2733::
2727:2
2712:.
2692::
2674:.
2660::
2639:.
2625::
2604:.
2590::
2569:.
2555::
2534:.
2512::
2491:.
2477::
2456:.
2434::
2413:.
2393::
2376:.
2362::
2341:.
2321::
2304:.
2283:.
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2225::
2198:.
2176::
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2141:.
2129::
2105:.
2083::
2056:.
2036::
2009:.
1997::
1973:.
1959::
1932:.
1918::
1891:.
1877::
1850:.
1836::
1809:.
1787::
1760:.
1736::
1728::
1701:.
1679::
1652:.
1628::
1622:3
1598:.
1586::
1559:.
1541:.
230:)
127:)
110::
20:)
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