Knowledge

Splenocyte

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The marginal zone (MZ) separates the red and white pulp regions and contains macrophages, B cells, and dendritic cells. MZ macrophages remove some types of blood-borne bacteria and viruses. MZ B and dendritic cells are involved in antigen processing and presentation to
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The white pulp contains separate compartments for B and T cells called the B cell zone (BCZ) and the T cell zone (TCZ). B cells make antibodies to fight off bacterial, viral, and fungal infections, and T cells are activated in response to antigens.
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Splenocytes consist of a variety of cell populations such as T and B lymphocytes, dendritic cells and macrophages, which have different immune functions.
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separating the two areas. The red pulp is involved with filtering blood and recycling iron, while the white pulp is involved in the immune response.
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is a white blood cell that resides in the spleen and are involved in functions of the spleen, like filtering blood and the immune response.
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An image of the spleen in the human body. Also shows the red and white pulp regions.
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You can help Knowledge by 468:Extramedullary hematopoiesis 166:10.1016/j.immuni.2013.10.010 59:. The spleen is split into 940: 836: 218:10.1126/sciimmunol.aau6085 634:Antigen-presenting cells 422: 397: 359: 319: 722:Nucleated red blood cell 278:Myeloid blood cells and 824:Hematopoietic stem cell 743:Leukocyte extravasation 612:Foreign-body giant cell 909:Mononuclear phagocytes 36: 34: 819:Hematopoietic system 607:Langhans giant cells 582:Alveolar macrophage 90:in the white pulp. 924:Cell biology stubs 753:Intrinsic immunity 617:Touton giant cells 206:Science Immunology 65:white pulp regions 37: 866: 865: 834: 833: 797: 796: 670: 669: 597:Epithelioid cells 476: 475: 456: 455: 452: 451: 384: 383: 931: 904:Spleen (anatomy) 887: 880: 873: 845: 838: 768:Precursor cells 694:Promegakaryocyte 560: 487: 412:Promegakaryocyte 395: 317: 308: 293: 272: 265: 258: 249: 240: 239: 229: 197: 188: 187: 177: 145: 128: 127: 125: 123: 117:Cleveland Clinic 109: 939: 938: 934: 933: 932: 930: 929: 928: 894: 893: 892: 891: 835: 830: 793: 757: 736:Immune response 731: 709:Red blood cells 703: 666: 643:Langerhans cell 638:Dendritic cells 623: 549: 472: 448: 432:Proerythroblast 418: 380: 364:Monocytopoiesis 355: 299: 282: 276: 244: 243: 199: 198: 191: 147: 146: 131: 121: 119: 111: 110: 101: 96: 53:dendritic cells 29: 12: 11: 5: 937: 935: 927: 926: 921: 916: 911: 906: 896: 895: 890: 889: 882: 875: 867: 864: 863: 846: 832: 831: 829: 828: 827: 826: 816: 811: 805: 803: 799: 798: 795: 794: 792: 791: 786: 785: 784: 779: 774: 765: 763: 759: 758: 756: 755: 750: 745: 739: 737: 733: 732: 730: 729: 724: 719: 713: 711: 705: 704: 702: 701: 696: 691: 689:Megakaryoblast 686: 680: 678: 672: 671: 668: 667: 665: 664: 663: 662: 652: 651: 650: 645: 640: 631: 629: 625: 624: 622: 621: 620: 619: 614: 609: 599: 594: 589: 584: 579: 574: 568: 566: 557: 551: 550: 548: 547: 546: 545: 535: 534: 533: 523: 522: 521: 511: 506: 501: 495: 493: 484: 482:Myeloid tissue 478: 477: 474: 473: 471: 470: 464: 462: 458: 457: 454: 453: 450: 449: 447: 446: 445: 444: 439: 434: 427:Erythropoiesis 423: 420: 419: 417: 416: 415: 414: 409: 407:Megakaryoblast 402:Thrombopoiesis 398: 392: 386: 385: 382: 381: 379: 378: 377: 376: 371: 360: 357: 356: 354: 353: 352: 351: 346: 341: 336: 331: 324:Granulopoiesis 320: 314: 305: 290: 284: 283: 277: 275: 274: 267: 260: 252: 242: 241: 189: 160:(5): 806–818. 129: 98: 97: 95: 92: 28: 25: 13: 10: 9: 6: 4: 3: 2: 936: 925: 922: 920: 917: 915: 912: 910: 907: 905: 902: 901: 899: 888: 883: 881: 876: 874: 869: 868: 862: 860: 856: 853:article is a 852: 847: 844: 840: 825: 822: 821: 820: 817: 815: 812: 810: 807: 806: 804: 800: 790: 789:Myelomonocyte 787: 783: 780: 778: 775: 773: 770: 769: 767: 766: 764: 760: 754: 751: 749: 746: 744: 741: 740: 738: 734: 728: 725: 723: 720: 718: 715: 714: 712: 710: 706: 700: 699:Megakaryocyte 697: 695: 692: 690: 687: 685: 682: 681: 679: 677: 673: 661: 658: 657: 656: 653: 649: 646: 644: 641: 639: 636: 635: 633: 632: 630: 626: 618: 615: 613: 610: 608: 605: 604: 603: 600: 598: 595: 593: 590: 588: 585: 583: 580: 578: 577:Kupffer cells 575: 573: 570: 569: 567: 565: 561: 558: 556: 552: 544: 541: 540: 539: 536: 532: 529: 528: 527: 524: 520: 517: 516: 515: 512: 510: 507: 505: 502: 500: 497: 496: 494: 492: 488: 485: 483: 479: 469: 466: 465: 463: 459: 443: 440: 438: 435: 433: 430: 429: 428: 425: 424: 421: 413: 410: 408: 405: 404: 403: 400: 399: 396: 393: 391: 387: 375: 372: 370: 367: 366: 365: 362: 361: 358: 350: 347: 345: 344:Metamyelocyte 342: 340: 337: 335: 332: 330: 327: 326: 325: 322: 321: 318: 315: 313: 309: 306: 303: 298: 294: 291: 289: 288:Hematopoiesis 285: 281: 273: 268: 266: 261: 259: 254: 253: 250: 246: 237: 233: 228: 223: 219: 215: 211: 207: 203: 196: 194: 190: 185: 181: 176: 171: 167: 163: 159: 155: 151: 144: 142: 140: 138: 136: 134: 130: 118: 114: 108: 106: 104: 100: 93: 91: 89: 83: 79: 77: 72: 70: 69:marginal zone 66: 62: 58: 54: 50: 46: 42: 33: 26: 24: 21: 19: 919:Cell biology 859:expanding it 851:cell biology 848: 748:Phagocytosis 717:Reticulocyte 491:Granulocytes 442:Reticulocyte 334:Promyelocyte 297:Myelopoiesis 245: 209: 205: 157: 153: 120:. Retrieved 116: 84: 80: 73: 38: 22: 17: 15: 602:giant cells 592:Osteoclasts 572:Histiocytes 564:Macrophages 374:Promonocyte 88:lymphocytes 76:phagocytose 57:macrophages 914:Leukocytes 898:Categories 526:Eosinophil 509:Neutrophil 499:Myeloblast 437:Normoblast 329:Myeloblast 94:References 41:leukocytes 18:splenocyte 809:Phagocyte 676:Platelets 655:Monoblast 587:Microglia 555:Monocytes 538:Mast cell 504:Band cell 369:Monoblast 349:Band cell 339:Myelocyte 67:with the 782:CFU-GEMM 543:CFU-Mast 519:CFU-Baso 514:Basophil 302:CFU-GEMM 236:30824527 184:24238338 154:Immunity 122:26 March 27:Overview 684:CFU-Meg 531:CFU-Eos 461:General 227:6495537 175:3912742 49:T cells 814:Plasma 772:CFU-GM 648:CFU-DL 312:CFU-GM 280:plasma 234:  224:  212:(33). 182:  172:  55:, and 849:This 802:Other 762:Other 727:CFU-E 628:Other 43:like 855:stub 232:PMID 180:PMID 124:2024 63:and 47:and 660:MPS 390:MEP 222:PMC 214:doi 170:PMC 162:doi 61:red 900:: 230:. 220:. 208:. 204:. 192:^ 178:. 168:. 158:39 156:. 152:. 132:^ 115:. 102:^ 51:, 16:A 886:e 879:t 872:v 861:. 304:) 300:( 271:e 264:t 257:v 238:. 216:: 210:4 186:. 164:: 126:. 45:B

Index


leukocytes
B
T cells
dendritic cells
macrophages
red
white pulp regions
marginal zone
phagocytose
lymphocytes



"Spleen: Function, Location & Size, Possible Problems"






"The spleen in local and systemic regulation of immunity"
doi
10.1016/j.immuni.2013.10.010
PMC
3912742
PMID
24238338

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