344:
321:
218:
243:
595:
350:
249:
3414:
47:
1381:
that result in an inactive conformation. To inhibit SFKs, CSK is then recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane and ultimately suppresses signaling through various surface receptors, including T-cell receptor (TCR) and
73:
1400:
organization, blood coagulation, brain development, cell differentiation, cell migration, cellular response to peptide hormone stimulus, central nervous system development, epidermal growth factor receptor signaling pathway, innate immune response, epithelium
1713:
Nada S, Okada M, MacAuley A, Cooper JA, Nakagawa H (May 1991). "Cloning of a complementary DNA for a protein-tyrosine kinase that specifically phosphorylates a negative regulatory site of p60c-src".
1461:
CSK is expressed in the lungs and macrophages as well as several other tissues. Tyrosine-Kinase CSK is mainly present in the cytoplasm, but also found in lipid rafts making cell-cell junction.
1923:
Bräuninger A, Holtrich U, Strebhardt K, Rübsamen-Waigmann H (Jan 1992). "Isolation and characterization of a human gene that encodes a new subclass of protein tyrosine kinases".
2059:
Fiorillo E, OrrĂş V, Stanford SM, Liu Y, Salek M, Rapini N, Schenone AD, Saccucci P, Delogu LG, Angelini F, Manca Bitti ML, Schmedt C, Chan AC, Acuto O, Bottini N (Aug 2010).
1764:
Nada S, Yagi T, Takeda H, Tokunaga T, Nakagawa H, Ikawa Y, Okada M, Aizawa S (Jun 1993). "Constitutive activation of Src family kinases in mouse embryos that lack Csk".
1858:
Chong YP, Mulhern TD, Cheng HC (Sep 2005). "C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases".
357:
256:
2559:
1678:
Sun G, Budde RJ (Sep 1997). "Expression, purification, and initial characterization of human Yes protein tyrosine kinase from a bacterial expression system".
2983:
2144:
1358:
1314:
31:
1003:
179:
984:
2856:
2282:
1807:
Chong YP, Chan AS, Chan KC, Williamson NA, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell AW, Scholz G, Mulhern TD, Cheng HC (Nov 2006).
2597:
3434:
2239:
1809:"C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases"
1585:
1567:
2267:
2635:
2626:
2326:
2321:
2316:
2311:
343:
2520:
2511:
1227:
3133:
2302:
1234:
320:
70:
2012:"Activation of the COOH-terminal Src kinase (Csk) by cAMP-dependent protein kinase inhibits signaling through the T cell receptor"
2205:
2061:"Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue"
1554:
1533:
2137:
242:
217:
3289:
1550:
2350:
1529:
2781:
2713:
2704:
1603:
155:
3087:
3078:
3014:
3058:
3404:
2525:
1963:"Identification of csk tyrosine phosphorylation sites and a tyrosine residue important for kinase domain structure"
356:
255:
3274:
3439:
3390:
3377:
3364:
3351:
3338:
3325:
3312:
2130:
1433:, dendrocyte differentiation, peptidyl-tyrosine autophosphorylation, platelet activation, positive regulation of
3284:
349:
248:
3238:
3181:
2175:
2161:
2116:
1048:
167:
2010:
Vang T, Torgersen KM, Sundvold V, Saxena M, Levy FO, Skålhegg BS, Hansson V, Mustelin T, Taskén K (Feb 2001).
1628:"The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity"
3186:
2899:
2890:
1426:
1029:
2188:
1626:
Bergman M, Mustelin T, Oetken C, Partanen J, Flint NA, Amrein KE, Autero M, Burn P, Alitalo K (Aug 1992).
3207:
3126:
2851:
2535:
231:
3279:
2112:
1722:
1370:
142:
3243:
2549:
1391:
1206:
1185:
1177:
1151:
1126:
1118:
3176:
2933:
2923:
2914:
2742:
2733:
1883:
1789:
1746:
1502:
191:
2122:
1365:
of Src family members at a conserved C-terminal tail site in Src. Upon phosphorylation by other
1210:
1181:
1147:
1122:
2967:
2092:
2041:
1992:
1940:
1875:
1840:
1781:
1738:
1695:
1657:
1397:
1382:
B-cell receptor (BCR) by phosphorylating and maintaining inactive several effector molecules.
1310:
135:
63:
3222:
3217:
3191:
3119:
2244:
2230:
2082:
2072:
2031:
2023:
1982:
1974:
1932:
1867:
1830:
1820:
1773:
1730:
1687:
1647:
1639:
1485:
436:
367:
311:
266:
2491:
3269:
3253:
3166:
2832:
2501:
2486:
2476:
2471:
2451:
2446:
2441:
2436:
2431:
2422:
2157:
1471:
1450:
1418:
1406:
1374:
1362:
1354:
411:
146:, Src, c-src tyrosine kinase, CSK/Src, non-receptor tyrosine kinase, C-terminal Src kinase
187:
1726:
594:
30:
This article is about the kinase CSK, for the kinase that is phosphorylated by CSK, see
3418:
3307:
3248:
2962:
2957:
2952:
2336:
2153:
2087:
2060:
2036:
2011:
1987:
1962:
1835:
1808:
1643:
1390:
Tyrosine-protein kinase CSK is involved in the following developmental, metabolic, and
1350:
1345:
This Non-receptor tyrosine-protein kinase plays an important role in the regulation of
1652:
1627:
918:
913:
908:
903:
898:
893:
888:
883:
878:
873:
868:
863:
858:
853:
848:
843:
838:
833:
828:
823:
818:
813:
808:
803:
798:
793:
788:
783:
778:
773:
757:
752:
747:
742:
737:
732:
727:
722:
706:
701:
696:
691:
686:
681:
676:
671:
666:
661:
656:
651:
646:
641:
636:
46:
3428:
3212:
3171:
2398:
2259:
1936:
1777:
1422:
1402:
623:
1887:
1793:
3161:
2943:
2654:
2645:
2389:
1750:
1430:
429:
208:
171:
17:
195:
3385:
3320:
3156:
1590:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1572:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1442:
1346:
3413:
1961:
Joukov V, Vihinen M, Vainikka S, Sowadski JM, Alitalo K, Bergman M (Mar 1997).
512:
3068:
3063:
3053:
3048:
3039:
2988:
2904:
2794:
1871:
1434:
1378:
1306:
328:
225:
175:
3359:
3333:
2077:
948:
572:
450:
395:
382:
294:
281:
183:
2096:
2045:
1879:
1844:
1825:
1691:
1425:
production, negative regulation of kinase activity, negative regulation of
2027:
1996:
1944:
1785:
1742:
1699:
1661:
1274:
2803:
2210:
1905:
1438:
1302:
1258:
1093:
1074:
1269:
1909:
1366:
1060:
1015:
1978:
112:
108:
104:
100:
96:
92:
3372:
3142:
3092:
2355:
2291:
2286:
1734:
1506:
1498:
1481:
1446:
1294:
1242:
970:
1409:, negative regulation of cell proliferation, negative regulation of
3346:
2880:
2758:
2723:
2718:
2694:
2496:
2481:
2466:
2461:
2456:
2408:
2403:
2379:
2374:
2365:
2277:
2272:
2249:
2220:
2215:
1477:
Y304F – Decreases activity by two-thirds and alters conformation.
933:
929:
834:
negative regulation of Golgi to plasma membrane protein transport
809:
negative regulation of low-density lipoprotein particle clearance
2998:
2928:
2875:
2866:
2827:
2818:
2808:
2689:
2680:
2670:
2616:
2607:
2592:
2583:
2573:
2568:
2544:
2345:
2197:
1414:
1410:
1334:
1298:
839:
regulation of Fc receptor mediated stimulatory signaling pathway
804:
transmembrane receptor protein tyrosine kinase signaling pathway
163:
159:
3115:
2779:
2173:
2126:
603:
3029:
3024:
3019:
2993:
1330:
1326:
1322:
1318:
1497:
Csk's interaction with a phosphatase ("Lyp", gene product of
1421:
to plasma membrane protein transport, negative regulation of
3111:
1437:
activity, regulation of cell proliferation, regulation of
743:
extrinsic component of cytoplasmic side of plasma membrane
419:
657:
non-membrane spanning protein tyrosine kinase activity
3402:
584:
899:
negative regulation of cell population proliferation
27:
Kinase enzyme that phosphorylates Src-family kinases
3298:
3262:
3231:
3200:
3149:
3077:
3038:
3007:
2976:
2942:
2913:
2889:
2865:
2841:
2817:
2793:
2751:
2732:
2703:
2679:
2663:
2644:
2625:
2606:
2582:
2558:
2534:
2510:
2421:
2388:
2364:
2335:
2301:
2258:
2229:
2196:
2187:
1199:
1170:
1140:
1111:
1546:
1544:
1542:
1525:
1523:
1521:
789:epidermal growth factor receptor signaling pathway
1899:
1897:
366:
265:
819:negative regulation of interleukin-6 production
1956:
1954:
1551:GRCm38: Ensembl release 89: ENSMUSG00000032312
1480:S364A – Strong decrease of phosphorylation by
1357:. CSK acts by suppressing the activity of the
3127:
2138:
1673:
1671:
1621:
1619:
859:cellular response to peptide hormone stimulus
8:
1904:Universal protein resource accession number
1501:) is possibly associated with the increased
874:negative regulation of ERK1 and ERK2 cascade
1530:GRCh38: Ensembl release 89: ENSG00000103653
1429:particle clearance, negative regulation of
864:regulation of cell population proliferation
3134:
3120:
3112:
2790:
2776:
2193:
2184:
2170:
2145:
2131:
2123:
944:
784:positive regulation of MAP kinase activity
652:protein kinase A catalytic subunit binding
619:
407:
306:
203:
81:
2115:at the U.S. National Library of Medicine
2086:
2076:
2035:
1986:
1834:
1824:
1651:
1445:mediated stimulatory signaling pathway,
3409:
1680:Archives of Biochemistry and Biophysics
1517:
1297:that, in humans, is encoded by the CSK
909:negative regulation of kinase activity
904:negative regulation of bone resorption
36:
1908:for "Tyrosine-protein kinase CSK" at
869:peptidyl-tyrosine autophosphorylation
371:
332:
327:
270:
229:
224:
7:
2016:The Journal of Experimental Medicine
1604:"Entrez Gene: C-src tyrosine kinase"
2065:The Journal of Biological Chemistry
1813:The Journal of Biological Chemistry
1457:Expression and subcellular location
794:negative regulation of phagocytosis
1644:10.1002/j.1460-2075.1992.tb05361.x
1386:Role in development and regulation
1196:
1167:
1137:
1108:
1084:
1065:
1039:
1020:
994:
975:
914:central nervous system development
589:
507:
445:
424:
25:
919:peptidyl-tyrosine phosphorylation
894:T cell receptor signaling pathway
844:regulation of cytokine production
3412:
1417:cascade, negative regulation of
682:protein tyrosine kinase activity
593:
355:
348:
342:
319:
254:
247:
241:
216:
45:
1369:, Src-family members engage in
829:oligodendrocyte differentiation
889:adherens junction organization
604:More reference expression data
573:More reference expression data
1:
2782:Non-receptor tyrosine kinases
1359:Src family of protein kinases
1301:. This enzyme phosphorylates
340:
239:
3435:Genes on human chromosome 15
1937:10.1016/0378-1119(92)90649-a
1778:10.1016/0092-8674(93)90642-4
2113:CSK tyrosine-protein kinase
1287:Tyrosine-protein kinase CSK
879:protein autophosphorylation
692:proline-rich region binding
687:protein phosphatase binding
497:stromal cell of endometrium
3456:
1484:(the catalytic subunit of
1441:production, regulation of
697:signaling receptor binding
667:protein C-terminus binding
485:mucosa of transverse colon
29:
3290:Michaelis–Menten kinetics
2789:
2775:
2183:
2176:Receptor tyrosine kinases
2169:
1872:10.1080/08977190500178877
1586:"Mouse PubMed Reference:"
1568:"Human PubMed Reference:"
1373:interactions between the
1273:
1268:
1264:
1257:
1241:
1222:
1203:
1174:
1163:
1144:
1115:
1104:
1091:
1087:
1072:
1068:
1059:
1046:
1042:
1027:
1023:
1014:
1001:
997:
982:
978:
969:
954:
947:
943:
927:
677:identical protein binding
622:
618:
601:
592:
583:
570:
519:
510:
457:
448:
418:
410:
406:
389:
376:
339:
318:
309:
305:
288:
275:
238:
215:
206:
202:
153:
150:
140:
133:
128:
89:
84:
67:
62:
57:
53:
44:
39:
3182:Diffusion-limited enzyme
2117:Medical Subject Headings
1305:residues located in the
779:adaptive immune response
2189:Growth factor receptors
2078:10.1074/jbc.M110.111104
1967:The Biochemical Journal
1427:low-density lipoprotein
1235:Chr 9: 57.53 – 57.56 Mb
1228:Chr 15: 74.78 – 74.8 Mb
849:protein phosphorylation
647:protein kinase activity
1826:10.1074/jbc.M602951200
1692:10.1006/abbi.1997.0236
884:innate immune response
539:neural layer of retina
527:mesenteric lymph nodes
3275:Eadie–Hofstee diagram
3208:Allosteric regulation
2028:10.1084/jem.193.4.497
1493:Clinical significance
1291:C-terminal Src kinase
814:immune system process
758:extracellular exosome
232:Chromosome 15 (human)
3285:Lineweaver–Burk plot
2260:PDGF receptor family
824:T cell costimulation
774:cell differentiation
637:transferase activity
334:Chromosome 9 (mouse)
85:List of PDB id codes
58:Available structures
2664:ROS receptor family
2198:EGF receptor family
1727:1991Natur.351...69N
1503:autoimmune diseases
1453:signaling pathway.
1392:signal transduction
1349:, differentiation,
373:9 B|9 31.18 cM
3244:Enzyme superfamily
3177:Enzyme promiscuity
1470:Y184F – Abolishes
1311:Src-family kinases
1049:ENSMUSG00000032312
767:Biological process
738:cell-cell junction
716:Cellular component
642:nucleotide binding
630:Molecular function
18:Src Family Kinases
3400:
3399:
3109:
3108:
3105:
3104:
3101:
3100:
2771:
2770:
2767:
2766:
2417:
2416:
1979:10.1042/bj3220927
1398:Adherens junction
1313:(SFKs) including
1284:
1283:
1280:
1279:
1253:
1252:
1218:
1217:
1193:
1192:
1159:
1158:
1134:
1133:
1100:
1099:
1081:
1080:
1055:
1054:
1036:
1035:
1010:
1009:
991:
990:
939:
938:
854:brain development
662:metal ion binding
614:
613:
610:
609:
579:
578:
566:
565:
504:
503:
493:bone marrow cells
402:
401:
301:
300:
124:
123:
120:
119:
68:Ortholog search:
16:(Redirected from
3447:
3440:Tyrosine kinases
3417:
3416:
3408:
3280:Hanes–Woolf plot
3223:Enzyme activator
3218:Enzyme inhibitor
3192:Enzyme catalysis
3136:
3129:
3122:
3113:
2791:
2777:
2231:Insulin receptor
2194:
2185:
2171:
2158:tyrosine kinases
2147:
2140:
2133:
2124:
2101:
2100:
2090:
2080:
2071:(34): 26506–18.
2056:
2050:
2049:
2039:
2007:
2001:
2000:
1990:
1958:
1949:
1948:
1920:
1914:
1913:
1901:
1892:
1891:
1855:
1849:
1848:
1838:
1828:
1819:(44): 32988–99.
1804:
1798:
1797:
1761:
1755:
1754:
1735:10.1038/351069a0
1710:
1704:
1703:
1675:
1666:
1665:
1655:
1632:The EMBO Journal
1623:
1614:
1613:
1611:
1610:
1600:
1594:
1593:
1582:
1576:
1575:
1564:
1558:
1548:
1537:
1527:
1505:associated with
1486:protein kinase A
1405:, regulation of
1266:
1265:
1237:
1230:
1213:
1197:
1188:
1168:
1164:RefSeq (protein)
1154:
1138:
1129:
1109:
1085:
1066:
1040:
1021:
995:
976:
945:
620:
606:
597:
590:
575:
547:ventricular zone
515:
513:Top expressed in
508:
453:
451:Top expressed in
446:
425:
408:
398:
385:
374:
359:
352:
346:
335:
323:
307:
297:
284:
273:
258:
251:
245:
234:
220:
204:
198:
145:
138:
115:
82:
76:
55:
54:
49:
37:
21:
3455:
3454:
3450:
3449:
3448:
3446:
3445:
3444:
3425:
3424:
3423:
3411:
3403:
3401:
3396:
3308:Oxidoreductases
3294:
3270:Enzyme kinetics
3258:
3254:List of enzymes
3227:
3196:
3167:Catalytic triad
3145:
3140:
3110:
3097:
3073:
3034:
3003:
2972:
2938:
2909:
2885:
2861:
2837:
2813:
2785:
2763:
2747:
2728:
2699:
2675:
2659:
2640:
2621:
2602:
2578:
2554:
2530:
2506:
2413:
2384:
2360:
2331:
2297:
2254:
2225:
2179:
2165:
2154:Protein kinases
2151:
2109:
2104:
2058:
2057:
2053:
2009:
2008:
2004:
1960:
1959:
1952:
1922:
1921:
1917:
1903:
1902:
1895:
1857:
1856:
1852:
1806:
1805:
1801:
1763:
1762:
1758:
1721:(6321): 69–72.
1712:
1711:
1707:
1677:
1676:
1669:
1625:
1624:
1617:
1608:
1606:
1602:
1601:
1597:
1584:
1583:
1579:
1566:
1565:
1561:
1549:
1540:
1528:
1519:
1515:
1495:
1472:phosphorylation
1467:
1459:
1451:T cell receptor
1449:costimulation,
1407:bone resorption
1388:
1375:phosphotyrosine
1363:phosphorylation
1355:immune response
1343:
1275:View/Edit Mouse
1270:View/Edit Human
1233:
1226:
1223:Location (UCSC)
1209:
1205:
1184:
1180:
1176:
1150:
1146:
1125:
1121:
1117:
1030:ENSG00000103653
923:
799:phosphorylation
762:
748:plasma membrane
711:
707:kinase activity
672:protein binding
602:
571:
562:
557:
553:
549:
545:
541:
537:
533:
529:
525:
511:
500:
495:
491:
487:
483:
479:
475:
471:
467:
463:
449:
393:
380:
372:
362:
361:
360:
353:
333:
310:Gene location (
292:
279:
271:
261:
260:
259:
252:
230:
207:Gene location (
196:CSK - orthologs
154:
141:
134:
91:
69:
35:
28:
23:
22:
15:
12:
11:
5:
3453:
3451:
3443:
3442:
3437:
3427:
3426:
3422:
3421:
3398:
3397:
3395:
3394:
3381:
3368:
3355:
3342:
3329:
3316:
3302:
3300:
3296:
3295:
3293:
3292:
3287:
3282:
3277:
3272:
3266:
3264:
3260:
3259:
3257:
3256:
3251:
3246:
3241:
3235:
3233:
3232:Classification
3229:
3228:
3226:
3225:
3220:
3215:
3210:
3204:
3202:
3198:
3197:
3195:
3194:
3189:
3184:
3179:
3174:
3169:
3164:
3159:
3153:
3151:
3147:
3146:
3141:
3139:
3138:
3131:
3124:
3116:
3107:
3106:
3103:
3102:
3099:
3098:
3096:
3095:
3090:
3084:
3082:
3075:
3074:
3072:
3071:
3066:
3061:
3056:
3051:
3045:
3043:
3036:
3035:
3033:
3032:
3027:
3022:
3017:
3011:
3009:
3005:
3004:
3002:
3001:
2996:
2991:
2986:
2980:
2978:
2974:
2973:
2971:
2970:
2965:
2960:
2955:
2949:
2947:
2940:
2939:
2937:
2936:
2931:
2926:
2920:
2918:
2911:
2910:
2908:
2907:
2902:
2896:
2894:
2887:
2886:
2884:
2883:
2878:
2872:
2870:
2863:
2862:
2860:
2859:
2854:
2848:
2846:
2839:
2838:
2836:
2835:
2830:
2824:
2822:
2815:
2814:
2812:
2811:
2806:
2800:
2798:
2787:
2786:
2780:
2773:
2772:
2769:
2768:
2765:
2764:
2762:
2761:
2755:
2753:
2749:
2748:
2746:
2745:
2739:
2737:
2730:
2729:
2727:
2726:
2721:
2716:
2710:
2708:
2701:
2700:
2698:
2697:
2692:
2686:
2684:
2681:AATYK receptor
2677:
2676:
2674:
2673:
2667:
2665:
2661:
2660:
2658:
2657:
2651:
2649:
2642:
2641:
2639:
2638:
2632:
2630:
2623:
2622:
2620:
2619:
2613:
2611:
2604:
2603:
2601:
2600:
2595:
2589:
2587:
2580:
2579:
2577:
2576:
2571:
2565:
2563:
2556:
2555:
2553:
2552:
2547:
2541:
2539:
2532:
2531:
2529:
2528:
2523:
2517:
2515:
2508:
2507:
2505:
2504:
2499:
2494:
2489:
2484:
2479:
2474:
2469:
2464:
2459:
2454:
2449:
2444:
2439:
2434:
2428:
2426:
2419:
2418:
2415:
2414:
2412:
2411:
2406:
2401:
2395:
2393:
2386:
2385:
2383:
2382:
2377:
2371:
2369:
2362:
2361:
2359:
2358:
2353:
2348:
2342:
2340:
2337:VEGF receptors
2333:
2332:
2330:
2329:
2324:
2319:
2314:
2308:
2306:
2299:
2298:
2296:
2295:
2289:
2280:
2275:
2270:
2264:
2262:
2256:
2255:
2253:
2252:
2247:
2242:
2236:
2234:
2227:
2226:
2224:
2223:
2218:
2213:
2208:
2202:
2200:
2191:
2181:
2180:
2174:
2167:
2166:
2152:
2150:
2149:
2142:
2135:
2127:
2121:
2120:
2108:
2107:External links
2105:
2103:
2102:
2051:
2022:(4): 497–507.
2002:
1950:
1915:
1893:
1860:Growth Factors
1850:
1799:
1772:(6): 1125–35.
1756:
1705:
1667:
1638:(8): 2919–24.
1615:
1595:
1577:
1559:
1538:
1516:
1514:
1511:
1494:
1491:
1490:
1489:
1478:
1475:
1466:
1463:
1458:
1455:
1387:
1384:
1371:intramolecular
1342:
1339:
1289:also known as
1282:
1281:
1278:
1277:
1272:
1262:
1261:
1255:
1254:
1251:
1250:
1248:
1246:
1239:
1238:
1231:
1224:
1220:
1219:
1216:
1215:
1201:
1200:
1194:
1191:
1190:
1172:
1171:
1165:
1161:
1160:
1157:
1156:
1142:
1141:
1135:
1132:
1131:
1113:
1112:
1106:
1102:
1101:
1098:
1097:
1089:
1088:
1082:
1079:
1078:
1070:
1069:
1063:
1057:
1056:
1053:
1052:
1044:
1043:
1037:
1034:
1033:
1025:
1024:
1018:
1012:
1011:
1008:
1007:
999:
998:
992:
989:
988:
980:
979:
973:
967:
966:
961:
956:
952:
951:
941:
940:
937:
936:
925:
924:
922:
921:
916:
911:
906:
901:
896:
891:
886:
881:
876:
871:
866:
861:
856:
851:
846:
841:
836:
831:
826:
821:
816:
811:
806:
801:
796:
791:
786:
781:
776:
770:
768:
764:
763:
761:
760:
755:
750:
745:
740:
735:
730:
725:
719:
717:
713:
712:
710:
709:
704:
699:
694:
689:
684:
679:
674:
669:
664:
659:
654:
649:
644:
639:
633:
631:
627:
626:
616:
615:
612:
611:
608:
607:
599:
598:
587:
581:
580:
577:
576:
568:
567:
564:
563:
561:
560:
556:
552:
548:
544:
540:
536:
532:
528:
524:
520:
517:
516:
505:
502:
501:
499:
498:
494:
490:
486:
482:
478:
474:
470:
466:
462:
458:
455:
454:
442:
441:
433:
422:
416:
415:
412:RNA expression
404:
403:
400:
399:
391:
387:
386:
378:
375:
370:
364:
363:
354:
347:
341:
337:
336:
331:
325:
324:
316:
315:
303:
302:
299:
298:
290:
286:
285:
277:
274:
269:
263:
262:
253:
246:
240:
236:
235:
228:
222:
221:
213:
212:
200:
199:
152:
148:
147:
139:
131:
130:
126:
125:
122:
121:
118:
117:
87:
86:
78:
77:
66:
60:
59:
51:
50:
42:
41:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
3452:
3441:
3438:
3436:
3433:
3432:
3430:
3420:
3415:
3410:
3406:
3392:
3388:
3387:
3382:
3379:
3375:
3374:
3369:
3366:
3362:
3361:
3356:
3353:
3349:
3348:
3343:
3340:
3336:
3335:
3330:
3327:
3323:
3322:
3317:
3314:
3310:
3309:
3304:
3303:
3301:
3297:
3291:
3288:
3286:
3283:
3281:
3278:
3276:
3273:
3271:
3268:
3267:
3265:
3261:
3255:
3252:
3250:
3249:Enzyme family
3247:
3245:
3242:
3240:
3237:
3236:
3234:
3230:
3224:
3221:
3219:
3216:
3214:
3213:Cooperativity
3211:
3209:
3206:
3205:
3203:
3199:
3193:
3190:
3188:
3185:
3183:
3180:
3178:
3175:
3173:
3172:Oxyanion hole
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3154:
3152:
3148:
3144:
3137:
3132:
3130:
3125:
3123:
3118:
3117:
3114:
3094:
3091:
3089:
3086:
3085:
3083:
3080:
3076:
3070:
3067:
3065:
3062:
3060:
3057:
3055:
3052:
3050:
3047:
3046:
3044:
3041:
3037:
3031:
3028:
3026:
3023:
3021:
3018:
3016:
3013:
3012:
3010:
3006:
3000:
2997:
2995:
2992:
2990:
2987:
2985:
2982:
2981:
2979:
2975:
2969:
2966:
2964:
2961:
2959:
2956:
2954:
2951:
2950:
2948:
2945:
2941:
2935:
2932:
2930:
2927:
2925:
2922:
2921:
2919:
2916:
2912:
2906:
2903:
2901:
2898:
2897:
2895:
2892:
2888:
2882:
2879:
2877:
2874:
2873:
2871:
2868:
2864:
2858:
2855:
2853:
2850:
2849:
2847:
2844:
2840:
2834:
2831:
2829:
2826:
2825:
2823:
2820:
2816:
2810:
2807:
2805:
2802:
2801:
2799:
2796:
2792:
2788:
2784:(EC 2.7.10.2)
2783:
2778:
2774:
2760:
2757:
2756:
2754:
2752:uncategorised
2750:
2744:
2741:
2740:
2738:
2735:
2731:
2725:
2722:
2720:
2717:
2715:
2712:
2711:
2709:
2706:
2702:
2696:
2693:
2691:
2688:
2687:
2685:
2682:
2678:
2672:
2669:
2668:
2666:
2662:
2656:
2653:
2652:
2650:
2647:
2646:MuSK receptor
2643:
2637:
2634:
2633:
2631:
2628:
2624:
2618:
2615:
2614:
2612:
2609:
2608:PTK7 receptor
2605:
2599:
2596:
2594:
2591:
2590:
2588:
2585:
2581:
2575:
2572:
2570:
2567:
2566:
2564:
2561:
2557:
2551:
2548:
2546:
2543:
2542:
2540:
2537:
2533:
2527:
2524:
2522:
2519:
2518:
2516:
2513:
2509:
2503:
2500:
2498:
2495:
2493:
2490:
2488:
2485:
2483:
2480:
2478:
2475:
2473:
2470:
2468:
2465:
2463:
2460:
2458:
2455:
2453:
2450:
2448:
2445:
2443:
2440:
2438:
2435:
2433:
2430:
2429:
2427:
2424:
2420:
2410:
2407:
2405:
2402:
2400:
2397:
2396:
2394:
2391:
2387:
2381:
2378:
2376:
2373:
2372:
2370:
2367:
2363:
2357:
2354:
2352:
2349:
2347:
2344:
2343:
2341:
2338:
2334:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2309:
2307:
2304:
2300:
2293:
2290:
2288:
2284:
2281:
2279:
2276:
2274:
2271:
2269:
2266:
2265:
2263:
2261:
2257:
2251:
2248:
2246:
2243:
2241:
2238:
2237:
2235:
2232:
2228:
2222:
2219:
2217:
2214:
2212:
2209:
2207:
2204:
2203:
2201:
2199:
2195:
2192:
2190:
2186:
2182:
2178:(EC 2.7.10.1)
2177:
2172:
2168:
2163:
2159:
2155:
2148:
2143:
2141:
2136:
2134:
2129:
2128:
2125:
2118:
2114:
2111:
2110:
2106:
2098:
2094:
2089:
2084:
2079:
2074:
2070:
2066:
2062:
2055:
2052:
2047:
2043:
2038:
2033:
2029:
2025:
2021:
2017:
2013:
2006:
2003:
1998:
1994:
1989:
1984:
1980:
1976:
1973:(3): 927–35.
1972:
1968:
1964:
1957:
1955:
1951:
1946:
1942:
1938:
1934:
1931:(2): 205–11.
1930:
1926:
1919:
1916:
1911:
1907:
1900:
1898:
1894:
1889:
1885:
1881:
1877:
1873:
1869:
1866:(3): 233–44.
1865:
1861:
1854:
1851:
1846:
1842:
1837:
1832:
1827:
1822:
1818:
1814:
1810:
1803:
1800:
1795:
1791:
1787:
1783:
1779:
1775:
1771:
1767:
1760:
1757:
1752:
1748:
1744:
1740:
1736:
1732:
1728:
1724:
1720:
1716:
1709:
1706:
1701:
1697:
1693:
1689:
1686:(1): 135–42.
1685:
1681:
1674:
1672:
1668:
1663:
1659:
1654:
1649:
1645:
1641:
1637:
1633:
1629:
1622:
1620:
1616:
1605:
1599:
1596:
1591:
1587:
1581:
1578:
1573:
1569:
1563:
1560:
1556:
1552:
1547:
1545:
1543:
1539:
1535:
1531:
1526:
1524:
1522:
1518:
1512:
1510:
1508:
1504:
1500:
1492:
1487:
1483:
1479:
1476:
1473:
1469:
1468:
1464:
1462:
1456:
1454:
1452:
1448:
1444:
1440:
1436:
1432:
1428:
1424:
1423:interleukin-6
1420:
1416:
1412:
1408:
1404:
1403:morphogenesis
1399:
1395:
1393:
1385:
1383:
1380:
1377:tail and the
1376:
1372:
1368:
1364:
1360:
1356:
1352:
1348:
1340:
1338:
1336:
1332:
1328:
1324:
1320:
1316:
1312:
1308:
1304:
1300:
1296:
1292:
1288:
1276:
1271:
1267:
1263:
1260:
1256:
1249:
1247:
1244:
1240:
1236:
1232:
1229:
1225:
1221:
1214:
1212:
1208:
1202:
1198:
1195:
1189:
1187:
1183:
1179:
1173:
1169:
1166:
1162:
1155:
1153:
1149:
1143:
1139:
1136:
1130:
1128:
1124:
1120:
1114:
1110:
1107:
1105:RefSeq (mRNA)
1103:
1096:
1095:
1090:
1086:
1083:
1077:
1076:
1071:
1067:
1064:
1062:
1058:
1051:
1050:
1045:
1041:
1038:
1032:
1031:
1026:
1022:
1019:
1017:
1013:
1006:
1005:
1000:
996:
993:
987:
986:
981:
977:
974:
972:
968:
965:
962:
960:
957:
953:
950:
946:
942:
935:
931:
926:
920:
917:
915:
912:
910:
907:
905:
902:
900:
897:
895:
892:
890:
887:
885:
882:
880:
877:
875:
872:
870:
867:
865:
862:
860:
857:
855:
852:
850:
847:
845:
842:
840:
837:
835:
832:
830:
827:
825:
822:
820:
817:
815:
812:
810:
807:
805:
802:
800:
797:
795:
792:
790:
787:
785:
782:
780:
777:
775:
772:
771:
769:
766:
765:
759:
756:
754:
753:membrane raft
751:
749:
746:
744:
741:
739:
736:
734:
731:
729:
726:
724:
721:
720:
718:
715:
714:
708:
705:
703:
700:
698:
695:
693:
690:
688:
685:
683:
680:
678:
675:
673:
670:
668:
665:
663:
660:
658:
655:
653:
650:
648:
645:
643:
640:
638:
635:
634:
632:
629:
628:
625:
624:Gene ontology
621:
617:
605:
600:
596:
591:
588:
586:
582:
574:
569:
558:
554:
550:
546:
542:
538:
534:
530:
526:
522:
521:
518:
514:
509:
506:
496:
492:
488:
484:
480:
476:
472:
468:
464:
460:
459:
456:
452:
447:
444:
443:
440:
438:
434:
432:
431:
427:
426:
423:
421:
417:
413:
409:
405:
397:
392:
388:
384:
379:
369:
365:
358:
351:
345:
338:
330:
326:
322:
317:
313:
308:
304:
296:
291:
287:
283:
278:
268:
264:
257:
250:
244:
237:
233:
227:
223:
219:
214:
210:
205:
201:
197:
193:
189:
185:
181:
177:
173:
169:
165:
161:
157:
149:
144:
137:
132:
127:
116:
114:
110:
106:
102:
98:
94:
88:
83:
80:
79:
75:
72:
65:
61:
56:
52:
48:
43:
38:
33:
19:
3386:Translocases
3383:
3370:
3357:
3344:
3331:
3321:Transferases
3318:
3305:
3162:Binding site
3008:SRC-B family
2977:SRC-A family
2842:
2734:RET receptor
2705:AXL receptor
2627:RYK receptor
2584:DDR receptor
2560:ROR receptor
2536:TIE receptor
2512:LTK receptor
2423:EPH receptor
2390:Trk receptor
2366:HGF receptor
2303:FGF receptor
2068:
2064:
2054:
2019:
2015:
2005:
1970:
1966:
1928:
1924:
1918:
1863:
1859:
1853:
1816:
1812:
1802:
1769:
1765:
1759:
1718:
1714:
1708:
1683:
1679:
1635:
1631:
1607:. Retrieved
1598:
1589:
1580:
1571:
1562:
1496:
1460:
1431:phagocytosis
1396:
1389:
1344:
1290:
1286:
1285:
1207:NP_001291690
1204:
1186:NP_001341917
1178:NP_001120662
1175:
1152:NM_001304761
1145:
1127:NM_001354988
1119:NM_001127190
1116:
1092:
1073:
1047:
1028:
1002:
983:
963:
958:
435:
428:
151:External IDs
90:
3157:Active site
1509:mutations.
1443:Fc receptor
1347:cell growth
702:ATP binding
523:granulocyte
461:granulocyte
394:57,560,914
381:57,533,929
293:74,803,198
280:74,782,057
129:Identifiers
74:H3BU69 RCSB
71:H3BU69 PDBe
3429:Categories
3360:Isomerases
3334:Hydrolases
3201:Regulation
1609:2013-07-11
1557:, May 2017
1536:, May 2017
1513:References
1435:MAP kinase
1394:cascades:
1379:SH2 domain
1307:C-terminal
477:lymph node
439:(ortholog)
176:HomoloGene
3239:EC number
1465:Mutations
1351:migration
1211:NP_031809
1182:NP_004374
1148:NM_007783
1123:NM_004383
949:Orthologs
723:cytoplasm
184:GeneCards
3263:Kinetics
3187:Cofactor
3150:Activity
2097:20538612
2046:11181701
1888:38227036
1880:16243715
1845:16959780
1794:37988394
1553:–
1532:–
1439:cytokine
1341:Function
1303:tyrosine
1259:Wikidata
928:Sources:
733:membrane
559:gastrula
555:yolk sac
481:appendix
465:monocyte
3419:Biology
3373:Ligases
3143:Enzymes
2164:2.7.10)
2088:2924087
2037:2195911
1997:9148770
1988:1218276
1945:1371489
1910:UniProt
1836:4281726
1786:8513497
1751:4363527
1743:1709258
1723:Bibcode
1700:9281320
1662:1639064
1555:Ensembl
1534:Ensembl
1367:kinases
1309:end of
1061:UniProt
1016:Ensembl
955:Species
934:QuickGO
728:cytosol
414:pattern
272:15q24.1
136:Aliases
3405:Portal
3347:Lyases
3081:family
3042:family
2946:family
2917:family
2893:family
2869:family
2845:family
2821:family
2797:family
2736:family
2707:family
2695:AATYK2
2683:family
2648:family
2629:family
2610:family
2586:family
2562:family
2538:family
2514:family
2425:family
2392:family
2368:family
2356:VEGFR3
2351:VEGFR2
2346:VEGFR1
2339:family
2305:family
2292:PDGFRB
2287:PDGFRA
2233:family
2119:(MeSH)
2095:
2085:
2044:
2034:
1995:
1985:
1943:
1906:P41240
1886:
1878:
1843:
1833:
1792:
1784:
1749:
1741:
1715:Nature
1698:
1660:
1653:556773
1650:
1507:PTPN22
1499:PTPN22
1482:PRKACA
1447:T cell
1295:enzyme
1293:is an
1245:search
1243:PubMed
1094:P41241
1075:P41240
971:Entrez
585:BioGPS
535:spleen
531:thymus
489:tonsil
469:spleen
164:124095
160:190090
3299:Types
3093:ZAP70
2759:STYK1
2724:TYRO3
2690:AATYK
2497:EPHB6
2492:EPHB5
2487:EPHB4
2482:EPHB3
2477:EPHB2
2472:EPHB1
2467:EPHA8
2462:EPHA7
2457:EPHA6
2452:EPHA5
2447:EPHA4
2442:EPHA3
2437:EPHA2
2432:EPHA1
2409:NTRK3
2404:NTRK2
2399:NTRK1
2327:FGFR4
2322:FGFR3
2317:FGFR2
2312:FGFR1
2283:PDGFR
2268:CSF1R
2250:INSRR
2240:IGF1R
2221:ERBB4
2216:ERBB3
2211:ERBB2
1884:S2CID
1790:S2CID
1747:S2CID
1419:Golgi
1004:12988
964:Mouse
959:Human
930:Amigo
551:blood
473:blood
437:Mouse
430:Human
377:Start
312:Mouse
276:Start
209:Human
180:55818
172:88537
32:c-Src
3391:list
3384:EC7
3378:list
3371:EC6
3365:list
3358:EC5
3352:list
3345:EC4
3339:list
3332:EC3
3326:list
3319:EC2
3313:list
3306:EC1
2999:YES1
2968:TYK2
2963:JAK3
2958:JAK2
2953:JAK1
2934:SRMS
2881:PYK2
2857:MATK
2833:TNK1
2828:ACK1
2804:ABL1
2671:ROS1
2655:MUSK
2617:PTK7
2598:DDR2
2593:DDR1
2574:ROR2
2569:ROR1
2502:EPHX
2273:FLT3
2245:INSR
2206:EGFR
2093:PMID
2042:PMID
1993:PMID
1941:PMID
1925:Gene
1876:PMID
1841:PMID
1782:PMID
1766:Cell
1739:PMID
1696:PMID
1658:PMID
1415:ERK2
1413:and
1411:ERK1
1353:and
1335:YES1
1333:and
1299:gene
985:1445
420:Bgee
368:Band
329:Chr.
267:Band
226:Chr.
156:OMIM
113:3EAZ
109:3EAC
105:3D7U
101:3D7T
97:1CSK
93:1BYG
3088:SYK
3079:SYK
3069:TXK
3064:ITK
3059:BTK
3054:BMX
3049:TEC
3040:TEC
3030:LYN
3025:LCK
3020:HCK
3015:BLK
2994:FYN
2989:FGR
2984:SRC
2944:JAK
2929:BRK
2924:FRK
2915:FRK
2905:FER
2900:FES
2891:FES
2876:FAK
2867:FAK
2852:CSK
2843:CSK
2819:ACK
2809:ARG
2795:ABL
2743:RET
2719:MER
2714:AXL
2636:RYK
2550:TEK
2545:TIE
2526:ALK
2521:LTK
2380:RON
2375:MET
2278:KIT
2083:PMC
2073:doi
2069:285
2032:PMC
2024:doi
2020:193
1983:PMC
1975:doi
1971:322
1933:doi
1929:110
1868:doi
1831:PMC
1821:doi
1817:281
1774:doi
1731:doi
1719:351
1688:doi
1684:345
1648:PMC
1640:doi
1361:by
1331:LYN
1327:LCK
1323:FYN
1319:HCK
1315:SRC
543:lip
390:End
289:End
192:OMA
188:CSK
168:MGI
143:CSK
64:PDB
40:CSK
3431::
2162:EC
2156::
2091:.
2081:.
2067:.
2063:.
2040:.
2030:.
2018:.
2014:.
1991:.
1981:.
1969:.
1965:.
1953:^
1939:.
1927:.
1896:^
1882:.
1874:.
1864:23
1862:.
1839:.
1829:.
1815:.
1811:.
1788:.
1780:.
1770:73
1768:.
1745:.
1737:.
1729:.
1717:.
1694:.
1682:.
1670:^
1656:.
1646:.
1636:11
1634:.
1630:.
1618:^
1588:.
1570:.
1541:^
1520:^
1488:).
1337:.
1329:,
1325:,
1321:,
1317:,
932:/
396:bp
383:bp
295:bp
282:bp
190:;
186::
182:;
178::
174:;
170::
166:;
162:,
158::
111:,
107:,
103:,
99:,
95:,
3407::
3393:)
3389:(
3380:)
3376:(
3367:)
3363:(
3354:)
3350:(
3341:)
3337:(
3328:)
3324:(
3315:)
3311:(
3135:e
3128:t
3121:v
2294:)
2285:(
2160:(
2146:e
2139:t
2132:v
2099:.
2075::
2048:.
2026::
1999:.
1977::
1947:.
1935::
1912:.
1890:.
1870::
1847:.
1823::
1796:.
1776::
1753:.
1733::
1725::
1702:.
1690::
1664:.
1642::
1612:.
1592:.
1574:.
1474:.
314:)
211:)
194::
34:.
20:)
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