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Bamford, A. R J; Crook, A. M; Clark, J. E; Nademi, Z.; Dixon, G.; Paton, J. Y; Riddell, A.; Drobniewski, F.; Riordan, A. (2009). "Comparison of interferon- release assays and tuberculin skin test in predicting active tuberculosis (TB) in children in the UK: A paediatric TB network study".
1094:
206:
Meier, T.; Eulenbruch, H.-P.; Wrighton-Smith, P.; Enders, G.; Regnath, T. (2005). "Sensitivity of a new commercial enzyme-linked immunospot assay (T SPOT-TB) for diagnosis of tuberculosis in clinical practice".
209:
1039:
40:. The test is manufactured by Oxford Immunotec in the UK. It is available in most European countries, the United States as well as various other countries. It was developed by researchers at the
1084:
1074:
448:
Mandalakas, A. M.; Detjen, A. K.; Hesseling, A. C.; Benedetti, A.; Menzies, D. (2011). "Interferon-gamma release assays and childhood tuberculosis: Systematic review and meta-analysis".
152:
in children has also been questioned by other publications. A metaanalysis of studies in children with active tuberculosis published in 2011 suggests that the sensitivity of the T-SPOT.
1059:
102:
for stimulation. While the tuberculin skin test uses purified protein derivative, a heterogeneous mixture of more than two hundred different mycobacterial peptides, the T-SPOT.
144:
positive, indicating a sensitivity of 97.2%. However, more recent data from a study in children with active TB disease in the UK suggest that the sensitivity of the T-SPOT.
740:
1029:
68:, in a sample of blood. This gives an overall measurement of the host immune response against mycobacteria, which can reveal the presence of infection with
1024:
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522:
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Ritz, Nicole; Connell, Tom G.; Paxton, Georgia A.; Buttery, Jim P.; Curtis, Nigel; Ranganathan, Sarath C. (2008). Dheda, Keertan (ed.).
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may in fact be worse than that of the tuberculin skin test (sensitivity reported as 66% and 82%, respectively). The performance of
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890:
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37:
90:. This technique has the advantage that it is comparatively fast (results within 24 hours), and less influenced by previous
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Connell, Thomas G.; Tebruegge, Marc; Ritz, Nicole; Bryant, Penelope A.; Leslie, David; Curtis, Nigel (2010).
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405:"The potential danger of a solely interferon-Îł release assay-based approach to testing for latent
298:"A Three-Way Comparison of Tuberculin Skin Testing, QuantiFERON-TB Gold and T-SPOT.TB in Children"
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110:-specific antigens (peptides called ESAT-6 and CFP-10). ESAT-6 and CFP-10 are expressed by
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In one study in
Germany, 70 out of 72 patients with confirmed TB infection were T-SPOT.
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vaccination compared with the traditional testing method for latent tuberculosis, the
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Phipps
Institute for the Study, Treatment and Prevention of Tuberculosis
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Connell, T. G.; Tebruegge, M.; Ritz, N.; Bryant, P.; Curtis, N. (2010).
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European
Journal of Clinical Microbiology & Infectious Diseases
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http://www.isis-innovation.com/news/news/oxfordimmunotec-nov02.html
29:
495:
124:. Based on those test principles, it is thought that the T-SPOT.
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500:
364:"Indeterminate Interferon-Îł Release Assay Results in Children"
1040:
European and
Developing Countries Clinical Trials Partnership
78:(TB). Because this does not rely on production of a reliable
160:(pooled sensitivity reported as 84% and 80%, respectively).
450:
1085:
1075:
International Union
Against Tuberculosis and Lung Disease
98:. This is due to the fact that both tests use different
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The Global Fund to Fight AIDS, Tuberculosis and
Malaria
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909:
883:
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771:
684:
643:
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741:Microscopic Observation Drug Susceptibility assay
1030:Center for Global Infectious Disease Research
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16:ELISpot assay used for tuberculosis diagnosis
8:
1025:Campaign for Access to Essential Medicines
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509:
501:
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331:
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116:, but are absent from all currently used
368:The Pediatric Infectious Disease Journal
896:Extensively drug-resistant tuberculosis
169:
56:counts the number of antimycobacterial
1070:International Congress on Tuberculosis
86:, the technique can be used to detect
7:
901:Totally drug-resistant tuberculosis
14:
1227:Biochemistry detection reactions
1065:Global Plan to Stop Tuberculosis
891:Multidrug-resistant tuberculosis
634:
347:
255:Archives of Disease in Childhood
36:, which belongs to the group of
156:is very similar to that of the
150:interferon-gamma release assays
38:interferon gamma release assays
724:Interferon gamma release assay
626:Post-tuberculosis lung disease
419:(3): 263–4, author reply 265.
1:
1191:Tuberculosis in human culture
1035:Cure Cottages of Saranac Lake
1020:Adirondack Cottage Sanitarium
381:10.1097/INF.0b013e3181c4822f
323:10.1371/journal.pone.0002624
1181:Tuberculosis classification
564:Extrapulmonary tuberculosis
491:blood test for tuberculosis
122:nontuberculous mycobacteria
1248:
1156:List of tuberculosis cases
675:Mycobacterium tuberculosis
407:Mycobacterium tuberculosis
128:is more specific than the
113:Mycobacterium tuberculosis
108:Mycobacterium tuberculosis
71:Mycobacterium tuberculosis
1045:Glen Lake Children's Camp
1004:Edward Livingston Trudeau
944:Friedrich Franz Friedmann
632:
621:Giant multinucleated cell
594:Tuberculous lymphadenitis
223:10.1007/s10096-005-1377-8
74:, the causative agent of
1126:Tuberculosis elimination
705:Löwenstein–Jensen medium
82:response or recoverable
1131:2007 tuberculosis scare
911:History of tuberculosis
714:Chest photofluorography
654:Mycobacterium africanum
426:10.1136/thx.2010.143396
267:10.1136/adc.2009.169805
1206:World Tuberculosis Day
1196:Tuberculosis radiology
1090:National Jewish Health
686:Tuberculosis diagnosis
599:Tuberculous meningitis
548:Pulmonary tuberculosis
409:infection in children"
34:tuberculosis diagnosis
1186:Tuberculosis in China
1080:Millennium Foundation
792:4-Aminosalicylic acid
699:Auramine phenol stain
645:Mycobacterium species
541:associated conditions
496:Oxford Immunotec Ltd.
462:10.5588/ijtld.10.0631
1136:Baumgarten-Tangl law
1050:Glen Lake Sanatorium
668:Mycobacterium caprae
604:Miliary tuberculosis
579:Canga's bead symptom
539:Symptoms, signs and
158:tuberculin skin test
130:tuberculin skin test
96:tuberculin skin test
42:University of Oxford
1100:Stop TB Partnership
1055:Glenn Dale Hospital
694:Ziehl–Neelsen stain
661:Mycobacterium bovis
611:Latent tuberculosis
314:2008PLoSO...3.2624C
88:latent tuberculosis
954:Philip D'Arcy Hart
120:vaccines and most
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719:GeneXpert MTB/RIF
62:white blood cells
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984:Mario Raviglione
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584:Prosector's wart
569:Caseous necrosis
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136:Test performance
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66:interferon-gamma
58:effector T cells
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48:Test overview
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25:is a type of
24:
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1232:Tuberculosis
1176:Sunshine Way
1166:Preventorium
1151:Iowa Cow War
999:Madonna Swan
994:Lucius RĂĽedi
832:Pyrazinamide
822:Streptomycin
778:ATC code J04
756:Mantoux test
733:
673:
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659:
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574:Pott disease
532:Tuberculosis
488:
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374:(3): 285–6.
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308:(7): e2624.
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261:(3): 180–6.
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189:"How T-SPOT.
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76:tuberculosis
69:
53:
51:
44:in England.
21:
19:
18:
1105:TB Alliance
969:Robert Koch
855:BCG vaccine
827:Bedaquiline
807:Cycloserine
802:Capreomycin
729:QuantiFERON
703:Culture on
1221:Categories
1171:Sanatorium
989:Carl RĂĽedi
949:Max Gerson
884:Resistance
812:Rifampicin
797:Ethambutol
773:Management
746:Tuberculin
616:Paronychia
553:Ghon focus
164:References
863:M72/AS01E
787:Isoniazid
761:Tine test
751:Heaf test
734:T-SPOT.TB
32:used for
1161:Plombage
847:Vaccines
470:21669030
435:20980248
390:20190616
342:18612425
302:PLOS ONE
275:19815937
231:16133410
100:antigens
84:pathogen
80:antibody
1110:Unitaid
837:Rifater
707:and/or
487:T-SPOT.
333:2440545
310:Bibcode
283:7665520
239:9400363
52:T-SPOT.
27:ELISpot
20:T-SPOT.
1146:ESAT-6
1141:CFP-10
873:RBCG30
868:MVA85A
468:
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413:Thorax
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193:Works"
1119:Other
279:S2CID
235:S2CID
30:assay
709:MGIT
466:PMID
431:PMID
386:PMID
338:PMID
271:PMID
227:PMID
458:doi
421:doi
376:doi
328:PMC
318:doi
263:doi
219:doi
118:BCG
92:BCG
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489:TB
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191:TB
154:TB
146:TB
142:TB
132:.
126:TB
104:TB
60:,
54:TB
22:TB
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524:e
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